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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLE7</accession>
    <name>A0A096MLE7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology domain containing A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PLEKHA2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031525351.1">
        <property type="nucleotide sequence ID" value="XM_031669491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MLE7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000363"/>
    <dbReference type="Ensembl" id="ENSPANT00000018881.3">
        <property type="protein sequence ID" value="ENSPANP00000000363.3"/>
        <property type="gene ID" value="ENSPANG00000014536.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008039"/>
    <dbReference type="CTD" id="59339"/>
    <dbReference type="eggNOG" id="ENOG502QV0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158064"/>
    <dbReference type="HOGENOM" id="CLU_055135_1_0_1"/>
    <dbReference type="OMA" id="KCHPKEM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014536">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MLE7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001954">
        <property type="term" value="P:positive regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13271">
        <property type="entry name" value="PH2_TAPP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000049">
        <property type="entry name" value="pleckstrin homology domain-containing family A member 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="148"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000363.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="375" mass="41198" checksum="9D1ED1E0D90BCD9D" modified="2022-05-25" version="3">MGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGGGLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHAILRRSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTRPGISSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVPQTGEKLLPAGEASEDSLFTPRPGEGSTAGVLPSSRIRHRSEPQHPKEKPFMFNLDDENIRTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNH5</accession>
    <name>A0A096MNH5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MNH5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001201"/>
    <dbReference type="Ensembl" id="ENSPANT00000008266.3">
        <property type="protein sequence ID" value="ENSPANP00000001201.1"/>
        <property type="gene ID" value="ENSPANG00000015871.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016262"/>
    <dbReference type="HOGENOM" id="CLU_167761_0_1_1"/>
    <dbReference type="OMA" id="MHFIRQV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015871">
        <property type="expression patterns" value="Expressed in Ammon's horn and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="11854" checksum="869F9A2D97F9C851" modified="2014-11-26" version="1">MAASGAGDPLDAKRGEAPFAQRIDPTREKLTPEQLYSMWRAQLAQWQKVLPQRRTRNIVTRLGIGALVLAIYGYTFYSISQERFLDELEDEAKAARARALARASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNM3</accession>
    <name>A0A096MNM3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 36 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC36A2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003900442.1">
        <property type="nucleotide sequence ID" value="XM_003900393.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNM3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001269"/>
    <dbReference type="Ensembl" id="ENSPANT00000003389.3">
        <property type="protein sequence ID" value="ENSPANP00000001269.1"/>
        <property type="gene ID" value="ENSPANG00000023734.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023514"/>
    <dbReference type="KEGG" id="panu:101023514"/>
    <dbReference type="CTD" id="153201"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162044"/>
    <dbReference type="HOGENOM" id="CLU_009646_0_2_1"/>
    <dbReference type="OMA" id="SAMYVPN"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023734">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015193">
        <property type="term" value="F:L-proline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005297">
        <property type="term" value="F:proline:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF185">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="50"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="480" mass="52704" checksum="8C625B1E3C9EF4D2" modified="2014-11-26" version="1">MSVTKSTEGAVAVKLDLMSPPESAKKLENKDSTFLDESPSESPGLKKTKGITVIQALIHLVKGNMGTGILGLSLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQRFCKRLNKPFMDYGDTVMHGLEASPSAWLQNHAHWGRHIVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIAQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYISIGTLGYLRFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWALPLDLSIRLAMVCLTCLLAVLIPRLDLVISLVGSVSSSALALIIPPLLEVSTFYSEGMSPLIIFKDALISILGFVGFVVGTYQALDELLKSGDSPLFSNSTTFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MSH5</accession>
    <name>A0A096MSH5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">TRAB domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TRABD2A</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_021780707.2">
        <property type="nucleotide sequence ID" value="XM_021925015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MSH5"/>
    <dbReference type="Ensembl" id="ENSPANT00000026401.3">
        <property type="protein sequence ID" value="ENSPANP00000002744.3"/>
        <property type="gene ID" value="ENSPANG00000026230.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016491"/>
    <dbReference type="KEGG" id="panu:101016491"/>
    <dbReference type="CTD" id="129293"/>
    <dbReference type="eggNOG" id="ENOG502QPR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162805"/>
    <dbReference type="HOGENOM" id="CLU_035548_1_0_1"/>
    <dbReference type="OMA" id="DRYFRHE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026230">
        <property type="expression patterns" value="Expressed in ascending colon and 30 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MSH5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF7">
        <property type="entry name" value="METALLOPROTEASE TIKI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035170263" description="Metalloprotease TIKI" evidence="15">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002744.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="505" mass="57651" checksum="8D07EC6AAC9DA4A6" modified="2022-05-25" version="3">MSPWSWFLLQTLCLLPTGAAQRRGAPGAANCELKPQQSELNSFLWTIKRDPPSYFFGTIHVPYTRVWDFIPDNSKEAFLQSSTVYFELDLTDPYTISALTSCQMLPQGKNLQDVLPKDIYCRLKRHLEYVKLMMPSWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDIKSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVIFALNQTLLQQESLRAGSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPSFINATLPPQELITAQEIDSYLRRELIYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGRPIHKGKSKKTSTQPTLSTIFAPKVPTPEVPTPEAISSVHSTLPPPVSRPGSAHPPSDAEQKFRKKRRRPRRRQRLRQFSDLWVRLEESDMVPQLQVRVLDRHISTELQLPRHGHSHHSQMVASSACLSLWTPVFWVLVLAFQTETPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUD6</accession>
    <name>A0A096MUD6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ciliogenesis-associated TTC17-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CATIP</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in primary ciliogenesis by modulating actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CATIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908000.1">
        <property type="nucleotide sequence ID" value="XM_003907951.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MUD6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003437"/>
    <dbReference type="Ensembl" id="ENSPANT00000024415.3">
        <property type="protein sequence ID" value="ENSPANP00000003437.2"/>
        <property type="gene ID" value="ENSPANG00000019012.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022017"/>
    <dbReference type="KEGG" id="panu:101022017"/>
    <dbReference type="CTD" id="375307"/>
    <dbReference type="eggNOG" id="ENOG502QPJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154101"/>
    <dbReference type="HOGENOM" id="CLU_041155_0_0_1"/>
    <dbReference type="OMA" id="SPGCCMI"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019012">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 32 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22973">
        <property type="entry name" value="DD_CATIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048777">
        <property type="entry name" value="CATIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047501">
        <property type="entry name" value="DD_CATIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF3">
        <property type="entry name" value="CILIOGENESIS-ASSOCIATED TTC17-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21772">
        <property type="entry name" value="CATIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliogenesis-associated TTC17-interacting protein N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003437.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="387" mass="43694" checksum="218008B9C92C34D2" modified="2018-02-28" version="2">MSSKVYSTGSRAKDHQPSGVECLPLPEANAEAIDFLSSLHEEELQMLFFSESLAMVSDTGEPQGELTIEVQRGKYQEKLGVLTSCLFVHAFSRGFLDKMLCGNSLLGYLSEKLELMEQHSQDFIKFLILPMERKTSLLKQDDQLAVTRSIKEGEEVKTGVTSFPWSSIKGFVSEAANLVLLRVMAWRRMVPSNARFLALDTEGKLCYLTYQDLGFQTIQVDHQQAEVFIVEQTVHSEEGIPMSCQYYLLSDGHLAKRIQVGSPGCCIITKMPILREVDEIEPRPVFEKKPPVWEEDMELYSKFLDRKEELRLGHASYLRQHPEAHALISDFLLFLLLRQPEDVVTFAAEFFGPFDPRRPSSPALGSSHRPNPFRSLEPEGDARSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUH5</accession>
    <name>A0A096MUH5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small integral membrane protein 1 (Vel blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMIM1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017812074.1">
        <property type="nucleotide sequence ID" value="XM_017956585.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021791066.1">
        <property type="nucleotide sequence ID" value="XM_021935374.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021791067.1">
        <property type="nucleotide sequence ID" value="XM_021935375.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021791068.1">
        <property type="nucleotide sequence ID" value="XM_021935376.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519728.1">
        <property type="nucleotide sequence ID" value="XM_031663868.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519740.1">
        <property type="nucleotide sequence ID" value="XM_031663880.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519747.1">
        <property type="nucleotide sequence ID" value="XM_031663887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MUH5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003476"/>
    <dbReference type="Ensembl" id="ENSPANT00000013193.3">
        <property type="protein sequence ID" value="ENSPANP00000003476.1"/>
        <property type="gene ID" value="ENSPANG00000010293.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000656"/>
    <dbReference type="KEGG" id="panu:101000656"/>
    <dbReference type="CTD" id="388588"/>
    <dbReference type="eggNOG" id="ENOG502SASD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000060291"/>
    <dbReference type="HOGENOM" id="CLU_2621305_0_0_1"/>
    <dbReference type="OMA" id="SRWENSH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010293">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031744">
        <property type="entry name" value="SMIM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38503">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38503:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15875">
        <property type="entry name" value="DUF4731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="78" mass="8668" checksum="5FB2879DD0CB3CA3" modified="2014-11-26" version="1">MQPQESHVHYSRWEDGSRDGVSLGAVSSTEEASCCRRISQKLCTGKLGIAMKVLGGVALFWIIFILGYLTGYYVHKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MY12</accession>
    <name>A0A096MY12_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LLP homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein LAPS18-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LLPH</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906786.1">
        <property type="nucleotide sequence ID" value="XM_003906737.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MY12"/>
    <dbReference type="SMR" id="A0A096MY12"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004805"/>
    <dbReference type="Ensembl" id="ENSPANT00000014589.3">
        <property type="protein sequence ID" value="ENSPANP00000004805.1"/>
        <property type="gene ID" value="ENSPANG00000012379.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007473"/>
    <dbReference type="KEGG" id="panu:101007473"/>
    <dbReference type="CTD" id="84298"/>
    <dbReference type="eggNOG" id="KOG4811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012979"/>
    <dbReference type="HOGENOM" id="CLU_134502_0_0_1"/>
    <dbReference type="OMA" id="YGNYPVW"/>
    <dbReference type="OrthoDB" id="6257894at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012379">
        <property type="expression patterns" value="Expressed in axillary lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001099">
        <property type="term" value="F:basal RNA polymerase II transcription machinery binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060999">
        <property type="term" value="P:positive regulation of dendritic spine development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="129" mass="15241" checksum="1A24E284A4254ECC" modified="2014-11-26" version="1">MAKSLRSKWKRKMRAEKRKKNAPKELSRLKSILKLEGDVLMKDVQEIATVVVPKRKHCQEKMQCEVKDEKDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKREKGKGKSKAKAVKVAKGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZT8</accession>
    <name>A0A096MZT8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">C-type lectin domain family 4 member C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CLEC4C</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_017801114.1">
        <property type="nucleotide sequence ID" value="XM_017945625.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021777684.1">
        <property type="nucleotide sequence ID" value="XM_021921992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZT8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005495"/>
    <dbReference type="Ensembl" id="ENSPANT00000010640.3">
        <property type="protein sequence ID" value="ENSPANP00000005495.1"/>
        <property type="gene ID" value="ENSPANG00000014844.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013001"/>
    <dbReference type="KEGG" id="panu:101013001"/>
    <dbReference type="CTD" id="170482"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162867"/>
    <dbReference type="HOGENOM" id="CLU_049894_7_5_1"/>
    <dbReference type="OMA" id="QDRVSHN"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014844">
        <property type="expression patterns" value="Expressed in axillary lymph node and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000024">
        <property type="entry name" value="C-type lectin domain family 4 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0465">Mannose-binding</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="17">
        <location>
            <begin position="90"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="212" mass="24893" checksum="03000A8C907D36BD" modified="2014-11-26" version="1">MVPEEEPQDREKGVWWFQLKVWSVAVVSILLLCVCFTVSSVASHNFMYSKTVKRLSKLQEYQQYYPSLTCVMEGKHMEDWSCCPTPWTSFQSSCYFISTVMQSWTESQNNCSVMGADLVVINTKEEQDFITQNLKINSAYFLGLSDPKGWRHWQWVDQTPYNKNVTFWHSGEPNSPDERCAIINFRSEEWGWNDVHCHVPQKSICKMKKIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0J9</accession>
    <name>A0A096N0J9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIPRL</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893565.1">
        <property type="nucleotide sequence ID" value="XM_003893516.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0J9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005786"/>
    <dbReference type="Ensembl" id="ENSPANT00000024524.3">
        <property type="protein sequence ID" value="ENSPANP00000005786.3"/>
        <property type="gene ID" value="ENSPANG00000026389.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000320"/>
    <dbReference type="KEGG" id="panu:101000320"/>
    <dbReference type="CTD" id="261726"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006659"/>
    <dbReference type="HOGENOM" id="CLU_039187_2_0_1"/>
    <dbReference type="OMA" id="DMILFED"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026389">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0J9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005786.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="272" mass="31471" checksum="23A3B63BC517DCEA" modified="2022-05-25" version="3">MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISNLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPERIDPNPADSQKSTQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1D8</accession>
    <name>A0A096N1D8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TXNDC9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003909075.1">
        <property type="nucleotide sequence ID" value="XM_003909026.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183021.1">
        <property type="nucleotide sequence ID" value="XM_009184757.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183022.1">
        <property type="nucleotide sequence ID" value="XM_009184758.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1D8"/>
    <dbReference type="SMR" id="A0A096N1D8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006106"/>
    <dbReference type="Ensembl" id="ENSPANT00000016712.3">
        <property type="protein sequence ID" value="ENSPANP00000006106.1"/>
        <property type="gene ID" value="ENSPANG00000020436.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019355"/>
    <dbReference type="KEGG" id="panu:101019355"/>
    <dbReference type="CTD" id="10190"/>
    <dbReference type="eggNOG" id="KOG1672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015645"/>
    <dbReference type="HOGENOM" id="CLU_072378_2_0_1"/>
    <dbReference type="OMA" id="CVIAFID"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020436">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1D8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000141">
        <property type="entry name" value="Thioredoxin domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="226" mass="26502" checksum="40295124AAB2E042" modified="2014-11-26" version="1">MEADASVDMFSKVLENQLLQTTKLVEEHLDSEIQKLDQMDEDELERLKEKRLEALRKAQQQKQEWLSKGHGEYREIPSERDFFQEVKESKKVVCHFYRDSAFRCKILDRHLAILSKKHLETKFLKLNVEKAPFLCERLRIKVIPTLALVKDGKTQDYVVGFTDLGNTDDFTTESLEWRLGCSDILNYSGNLMEPPFQNQKKFGTNFTKLEKKTIRGKKYDSDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N384</accession>
    <name>A0A096N384_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Sortilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Neurotensin receptor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">SORT1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="27">Cell membrane</location>
            <topology evidence="27">Single-pass type I membrane protein</topology>
            <orientation evidence="27">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Golgi apparatus</location>
            <location evidence="29">Golgi stack membrane</location>
            <topology evidence="29">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Nucleus membrane</location>
            <topology evidence="28">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="30">Belongs to the VPS10-related sortilin family. SORT1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021777518.1">
        <property type="nucleotide sequence ID" value="XM_021921826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N384"/>
    <dbReference type="Ensembl" id="ENSPANT00000005008.3">
        <property type="protein sequence ID" value="ENSPANP00000006793.2"/>
        <property type="gene ID" value="ENSPANG00000009174.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101006123"/>
    <dbReference type="CTD" id="6272"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234563"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009174">
        <property type="expression patterns" value="Expressed in iris and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N384">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000003">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000802">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000004">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="26" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="24" id="KW-0458">Lysosome</keyword>
    <keyword evidence="19 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="20" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0675">Receptor</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 34" id="KW-0732">Signal</keyword>
    <keyword evidence="10 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="34">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030002855" description="Sortilin" evidence="34">
        <location>
            <begin position="34"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="35">
        <location>
            <begin position="133"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00046292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00060431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00061605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00068731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00080429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006793.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="831" mass="92134" checksum="7A5E6F0941B4CC40" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N4P6</accession>
    <name>A0A096N4P6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZFP92 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZFP92</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">KRAB domain-containing zinc-finger protein that represses B1/Alu SINE transposable elements and modulates the transcription of nearby genes in a tissue-specific manner. It regulates glucose homeostasis and lipid metabolism by modulating the expression of the endocrine cell-defining transcription factor, MAFB, in pancreatic islets and, the fat metabolism regulator, ACACB, in adipose tissue and muscle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009196744.1">
        <property type="nucleotide sequence ID" value="XM_009198480.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009196745.1">
        <property type="nucleotide sequence ID" value="XM_009198481.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809255.1">
        <property type="nucleotide sequence ID" value="XM_017953766.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N4P6"/>
    <dbReference type="Ensembl" id="ENSPANT00000027100.3">
        <property type="protein sequence ID" value="ENSPANP00000007371.1"/>
        <property type="gene ID" value="ENSPANG00000006612.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006080"/>
    <dbReference type="KEGG" id="panu:101006080"/>
    <dbReference type="CTD" id="139735"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162887"/>
    <dbReference type="HOGENOM" id="CLU_002678_0_9_1"/>
    <dbReference type="OMA" id="PQVCERC"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006612">
        <property type="expression patterns" value="Expressed in adrenal medulla and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010526">
        <property type="term" value="P:transposable element silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001207">
        <property type="entry name" value="zinc finger protein 837 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001111">
        <property type="entry name" value="Zinc finger protein 92 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001671">
        <property type="entry name" value="Zinc finger protein 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="416" mass="45843" checksum="7E82E8B081EE1A39" modified="2014-11-26" version="1">MAAILLTTRPKVPVSFEDVSVYFTKTEWKLLDLRQKVLYKRVMLENYSHLVSLGFSFSKPHLISQLERGEGPWVADIPRTWTTAGLHIGDRTQSKTSTSMQKHSGRQLPGVDSQGGKDGQAARSSVLQRGSQGLGPSSAAGPQGPKGAEKRYLCQQCGKAFSRSSNLIKHRIIHSGEKPYACRECGKLFRRSFALLEHQRIHSGEKPYACPECSKTFTRSSNLIKHQVIHSGERPFACGDCGKLFRRSFALLEHARVHSGERPYACPECGKAFSRSSNLIEHQRTHRGEKPYACGQCAKAFKGVSQLIHHQRSHSGERPFACRECGKAFRGRSGLSQHRRVHSGEKPYECSDCGKAFGRRANLFKHQAVHGARRPAKAETARRRAGPGSTGPGSALAASSPSPPSAAARPSRPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5U6</accession>
    <name>A0A096N5U6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="26">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">FAR2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>18-methylnonadecanoyl-CoA + 2 NADPH + 2 H(+) = 18-methylnonadecan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84914"/>
            <dbReference type="ChEBI" id="CHEBI:231999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:81768"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>20-methylheneicosanoyl-CoA + 2 NADPH + 2 H(+) = 20-methylheneicosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84915"/>
            <dbReference type="ChEBI" id="CHEBI:232000"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:81772"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>22-methyltricosanoyl-CoA + 2 NADPH + 2 H(+) = 22-methyltricosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84916"/>
            <dbReference type="ChEBI" id="CHEBI:232001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:81776"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>24-methylpentacosanoyl-CoA + 2 NADPH + 2 H(+) = 24-methylpentacosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81779"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84917"/>
            <dbReference type="ChEBI" id="CHEBI:232002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:81780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a very long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a very long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81751"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:138741"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:81752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an ultra-long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = an ultra long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81755"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:143016"/>
            <dbReference type="ChEBI" id="CHEBI:143018"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:81756"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31000"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:81732"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:75627"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81728"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28415"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64868"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81740"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoyl-CoA + 2 NADPH + 2 H(+) = hexadecan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:36315"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16125"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:36316"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>octacosanoyl-CoA + 2 NADPH + 2 H(+) = octacosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28243"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:74141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:81744"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:36319"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32154"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetracosanoyl-CoA + 2 NADPH + 2 H(+) = tetracosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:77413"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:81736"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>triacontanoyl-CoA + 2 NADPH + 2 H(+) = triacontan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81747"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28409"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:76386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:81748"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 26">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="26"/>
    <dbReference type="RefSeq" id="XP_009178728.3">
        <property type="nucleotide sequence ID" value="XM_009180464.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N5U6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007819"/>
    <dbReference type="Ensembl" id="ENSPANT00000009295.4">
        <property type="protein sequence ID" value="ENSPANP00000007819.2"/>
        <property type="gene ID" value="ENSPANG00000018372.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101004240"/>
    <dbReference type="KEGG" id="panu:101004240"/>
    <dbReference type="CTD" id="55711"/>
    <dbReference type="GeneTree" id="ENSGT00390000006367"/>
    <dbReference type="HOGENOM" id="CLU_024661_0_0_1"/>
    <dbReference type="OMA" id="WRFFIAR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018372">
        <property type="expression patterns" value="Expressed in putamen and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010025">
        <property type="term" value="P:wax biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000278">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF120">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 26" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 26" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 26" id="KW-0521">NADP</keyword>
    <keyword evidence="7 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="28">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="27">
        <location>
            <begin position="358"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007819.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="516" mass="59439" checksum="AF873E44DBFBD8BB" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N603</accession>
    <name>A0A096N603_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD repeat and FYVE domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WDFY2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N603"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007887"/>
    <dbReference type="Ensembl" id="ENSPANT00000005203.3">
        <property type="protein sequence ID" value="ENSPANP00000007887.3"/>
        <property type="gene ID" value="ENSPANG00000015000.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158527"/>
    <dbReference type="HOGENOM" id="CLU_046919_0_0_1"/>
    <dbReference type="OMA" id="EIRCLRW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015000">
        <property type="expression patterns" value="Expressed in bone marrow and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N603">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15718">
        <property type="entry name" value="FYVE_WDFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000285">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
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    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF3">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="473"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007887.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="601" mass="66038" checksum="E65837BE96EE7118" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N653</accession>
    <name>A0A096N653_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 25 member 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLC25A45</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909626.1">
        <property type="nucleotide sequence ID" value="XM_003909577.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183918.1">
        <property type="nucleotide sequence ID" value="XM_009185654.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N653"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007940"/>
    <dbReference type="Ensembl" id="ENSPANT00000008338.3">
        <property type="protein sequence ID" value="ENSPANP00000007940.1"/>
        <property type="gene ID" value="ENSPANG00000004415.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023228"/>
    <dbReference type="KEGG" id="panu:101023228"/>
    <dbReference type="CTD" id="283130"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161002"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_1_1"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004415">
        <property type="expression patterns" value="Expressed in pancreas and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N653">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000049">
        <property type="entry name" value="Solute carrier family 25 member 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="288" mass="31887" checksum="7FFC15C834BC2C54" modified="2014-11-26" version="1">MPVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLLLTATSHQERRAQPPSYTHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPVAQPGSPPPQYQGPMHCAASIFREEGYRGLFRGAWALMLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDVIKSRMQMDGLRRRVYQGVLDCMMSSVRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N890</accession>
    <name>A0A096N890_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adipolin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adipose-derived insulin-sensitizing factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Complement C1q tumor necrosis factor-related protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">C1QTNF12</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adipolin/erythroferrone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N890"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008816"/>
    <dbReference type="Ensembl" id="ENSPANT00000021988.3">
        <property type="protein sequence ID" value="ENSPANP00000008816.3"/>
        <property type="gene ID" value="ENSPANG00000021265.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160300"/>
    <dbReference type="HOGENOM" id="CLU_057344_1_0_1"/>
    <dbReference type="OMA" id="RCRGRDK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021265">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046628">
        <property type="term" value="P:positive regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000012">
        <property type="entry name" value="Adipolin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052136">
        <property type="entry name" value="Adipolin/Erythroferrone-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019:SF12">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035321111" description="Adipolin" evidence="13">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="14">
        <location>
            <begin position="140"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008816.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="295" mass="31858" checksum="B4AF1E5249A593A2" modified="2022-05-25" version="3">MRRWAWAVVAVLLGGLGARPEAQRTQQPGQRADPPNATASASSREGLPKAPKPSQASGPELSDAHMTWLNFVRRPDDSALRKRCGSRDKKQRDLFGPPGPPGAEVTPEILLREFQELLKEATEHRFSGLLDPLLPQRVGLRLVGEAFHCRLQGPRRVDKRTLVELHGFQAPAAQGAFLRGSGLSLASGRFTAPASGIFQFSASLLVDHSELQGKARLRARDVVRVLICIESLCQRHMSLEAISGLESNSRVFTAQVQGLLQLQAGQYASVFVDNGSGAVLTIQAGSSFSGLLLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8M3</accession>
    <name>A0A096N8M3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glucocorticoid modulatory element binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GMEB1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009201499.1">
        <property type="nucleotide sequence ID" value="XM_009203235.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009201505.1">
        <property type="nucleotide sequence ID" value="XM_009203241.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009201507.1">
        <property type="nucleotide sequence ID" value="XM_009203243.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8M3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008954"/>
    <dbReference type="Ensembl" id="ENSPANT00000022732.3">
        <property type="protein sequence ID" value="ENSPANP00000008954.1"/>
        <property type="gene ID" value="ENSPANG00000018743.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013638"/>
    <dbReference type="KEGG" id="panu:101013638"/>
    <dbReference type="CTD" id="10691"/>
    <dbReference type="eggNOG" id="KOG4333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00410000025596"/>
    <dbReference type="HOGENOM" id="CLU_030344_1_0_1"/>
    <dbReference type="OMA" id="SPINQQA"/>
    <dbReference type="OrthoDB" id="5792412at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018743">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051008">
        <property type="term" value="F:Hsp27 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000003">
        <property type="entry name" value="glucocorticoid modulatory element-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059099">
        <property type="entry name" value="GMEB1/2/Spe-44_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF3">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25892">
        <property type="entry name" value="Spe-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAND" evidence="13">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="573" mass="62605" checksum="352DF5F756D6AAE1" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8U5</accession>
    <name>A0A096N8U5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MEMO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mediator of ErbB2-driven cell motility 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MEMO1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908528.2">
        <property type="nucleotide sequence ID" value="XM_003908479.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8U5"/>
    <dbReference type="Ensembl" id="ENSPANT00000009777.3">
        <property type="protein sequence ID" value="ENSPANP00000009026.2"/>
        <property type="gene ID" value="ENSPANG00000022798.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026255"/>
    <dbReference type="KEGG" id="panu:101026255"/>
    <dbReference type="CTD" id="51072"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006408"/>
    <dbReference type="HOGENOM" id="CLU_038085_0_1_1"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022798">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N8U5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032886">
        <property type="term" value="P:regulation of microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.830.10:FF:000002">
        <property type="entry name" value="MEMO1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009026.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="297" mass="33650" checksum="5710ED44837E3E84" modified="2022-05-25" version="2">MSNRVVCREASHAGSCYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA50</accession>
    <name>A0A096NA50_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neuromedin-K receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">NK-3 receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Neurokinin B receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tachykinin receptor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TACR3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899092.2">
        <property type="nucleotide sequence ID" value="XM_003899043.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NA50"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009547"/>
    <dbReference type="Ensembl" id="ENSPANT00000010360.3">
        <property type="protein sequence ID" value="ENSPANP00000009547.2"/>
        <property type="gene ID" value="ENSPANG00000009532.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004662"/>
    <dbReference type="KEGG" id="panu:101004662"/>
    <dbReference type="CTD" id="6870"/>
    <dbReference type="eggNOG" id="KOG4219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153745"/>
    <dbReference type="HOGENOM" id="CLU_009579_6_6_1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 8 other cell types or tissues"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:sperm midpiece"/>
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        <property type="term" value="F:tachykinin receptor activity"/>
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        <property type="term" value="P:positive regulation of flagellated sperm motility"/>
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        <property type="entry name" value="Neuromedin-K receptor"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
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        <property type="entry name" value="NEUROMEDIN-K RECEPTOR"/>
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        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="NEUROKININ3R"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="21">
        <location>
            <begin position="102"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="416"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="158"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020039"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023139"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00031300"/>
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            <dbReference type="ARBA" id="ARBA00031717"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00032354"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601681-50"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009547.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="463" mass="51946" checksum="869E48A49B010B02" modified="2018-02-28" version="2">MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGTVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPRANLTNQFVQPSWRIALWSLAYGVVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPTRQSSMYTVTRMESMTVVFDPSDADTARSSRKKRATPRDPSFNGCSRRNSKSASTTSSFISSPYTSVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAW2</accession>
    <name>A0A096NAW2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 24">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="5 24">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NDUFV1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 24">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 24">Mitochondrion inner membrane</location>
            <topology evidence="3 24">Peripheral membrane protein</topology>
            <orientation evidence="3 24">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="5 24"/>
    <dbReference type="RefSeq" id="XP_021781171.2">
        <property type="nucleotide sequence ID" value="XM_021925479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NAW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009868"/>
    <dbReference type="Ensembl" id="ENSPANT00000018204.3">
        <property type="protein sequence ID" value="ENSPANP00000009868.3"/>
        <property type="gene ID" value="ENSPANG00000011236.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006922"/>
    <dbReference type="KEGG" id="panu:101006922"/>
    <dbReference type="CTD" id="4723"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010641"/>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011236">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 24" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15 24" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 24" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 24" id="KW-0288">FMN</keyword>
    <keyword evidence="17 24" id="KW-0408">Iron</keyword>
    <keyword evidence="18 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="24" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 24" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19 24" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 24" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="24" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="24" id="KW-0813">Transport</keyword>
    <keyword evidence="20" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="25">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009868.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="464" mass="50593" checksum="3F0733BB3E8FADB5" modified="2022-05-25" version="3">MLAARRLLGGSLPSRVSVRFSGDTTAPKKTSFGSLKDEDRIFSNLYGRHDWRLKGALSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNQPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDAQPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDG9</accession>
    <name>A0A096NDG9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger and BTB domain-containing protein 7C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Zinc finger and BTB domain-containing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZBTB7C</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May be a tumor suppressor gene.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003914407.1">
        <property type="nucleotide sequence ID" value="XM_003914358.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021785802.1">
        <property type="nucleotide sequence ID" value="XM_021930110.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDG9"/>
    <dbReference type="SMR" id="A0A096NDG9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010915"/>
    <dbReference type="Ensembl" id="ENSPANT00000002358.3">
        <property type="protein sequence ID" value="ENSPANP00000010915.1"/>
        <property type="gene ID" value="ENSPANG00000016942.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005484"/>
    <dbReference type="KEGG" id="panu:101005484"/>
    <dbReference type="CTD" id="201501"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159814"/>
    <dbReference type="HOGENOM" id="CLU_025627_2_0_1"/>
    <dbReference type="OMA" id="HLDMERN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016942">
        <property type="expression patterns" value="Expressed in esophagus and 37 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18328">
        <property type="entry name" value="BTB_POZ_ZBTB7C_ZBTB36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000043">
        <property type="entry name" value="Zinc finger and BTB domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000115">
        <property type="entry name" value="Zinc finger and BTB domain containing 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000138">
        <property type="entry name" value="Zinc finger and BTB domain containing 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000259">
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="zf-C2H2"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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        <property type="entry name" value="POZ domain"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="393"/>
            <end position="420"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="421"/>
            <end position="448"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="449"/>
            <end position="484"/>
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    </feature>
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        <location>
            <begin position="129"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="133"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00059598"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00070667"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081530"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50097"/>
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        <source>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="620" mass="69132" checksum="8883A105CDAE73ED" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEB0</accession>
    <name>A0A096NEB0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RAS protein activator like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RASAL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="Bgee" id="ENSPANG00000007320">
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="116"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="301"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="567"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011227.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="806" mass="90212" checksum="BC8FC3D63940A13B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEB2</accession>
    <name>A0A096NEB2_PAPAN</name>
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        <recommendedName>
            <fullName evidence="11">Protein NEDD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Neural precursor cell expressed developmentally down-regulated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NEDD1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subunit">
        <text evidence="10">Interacts with FAM29A. Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003906990.3"/>
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        <property type="nucleotide sequence ID" value="XM_009181472.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009179737.2">
        <property type="nucleotide sequence ID" value="XM_009181473.4"/>
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    <dbReference type="AlphaFoldDB" id="A0A096NEB2"/>
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        <property type="protein sequence ID" value="ENSPANP00000011229.3"/>
        <property type="gene ID" value="ENSPANG00000023046.3"/>
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    <dbReference type="GeneID" id="101015042"/>
    <dbReference type="KEGG" id="panu:101015042"/>
    <dbReference type="CTD" id="121441"/>
    <dbReference type="eggNOG" id="KOG4378">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000001561"/>
    <dbReference type="HOGENOM" id="CLU_415014_0_0_1"/>
    <dbReference type="OMA" id="GTMVLWD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="Bgee" id="ENSPANG00000023046">
        <property type="expression patterns" value="Expressed in testis and 63 other cell types or tissues"/>
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        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000242">
        <property type="term" value="C:pericentriolar material"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:microtubule nucleation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000284">
        <property type="entry name" value="protein NEDD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000302">
        <property type="entry name" value="protein NEDD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="NEDD1_Spindle_Assembly"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="PROTEIN NEDD1"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="6"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="81"/>
            <end position="114"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="532"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="523"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062972"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076994"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011229.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="660" mass="71938" checksum="66AC7BBBC587D4B9" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEK1</accession>
    <name>A0A096NEK1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MAST2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
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    <dbReference type="STRING" id="9555.ENSPANP00000011327"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
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        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 2"/>
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        <property type="entry name" value="MAST3 pre-PK domain-like"/>
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    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
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    <feature type="domain" description="PDZ" evidence="18">
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011327.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1795" mass="195964" checksum="1FA4EC652F042DF9" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEM8</accession>
    <name>A0A096NEM8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carboxypeptidase M</fullName>
            <ecNumber evidence="19">3.4.17.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CPM</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Cleavage of C-terminal arginine or lysine residues from polypeptides.</text>
            <dbReference type="EC" id="3.4.17.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.12" evidence="19"/>
    <dbReference type="RefSeq" id="XP_009179453.2">
        <property type="nucleotide sequence ID" value="XM_009181189.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NEM8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000034774"/>
    <dbReference type="Ensembl" id="ENSPANT00000015262.3">
        <property type="protein sequence ID" value="ENSPANP00000011355.1"/>
        <property type="gene ID" value="ENSPANG00000015540.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018002"/>
    <dbReference type="KEGG" id="panu:101018002"/>
    <dbReference type="CTD" id="1368"/>
    <dbReference type="eggNOG" id="KOG2649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158580"/>
    <dbReference type="HOGENOM" id="CLU_006722_1_0_1"/>
    <dbReference type="OMA" id="GHEPYLT"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015540">
        <property type="expression patterns" value="Expressed in lung and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03866">
        <property type="entry name" value="M14_CPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000014">
        <property type="entry name" value="Carboxypeptidase M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000041">
        <property type="entry name" value="Carboxypeptidase M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033842">
        <property type="entry name" value="CPM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="22">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="21">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="443" mass="50553" checksum="8699521F04FB728B" modified="2014-11-26" version="1">MNFPYLWLELLLPLVAALDFNYHHQEGMEAFLKTVAQNYSSITHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPDITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNRYDLNRNFPDAFEYNNVSRQPETLAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALSSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHLTKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYMNSPSHSPATKPSLFLFLVTLLHIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NF03</accession>
    <name>A0A096NF03_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Malonyl-CoA decarboxylase, mitochondrial</fullName>
            <ecNumber evidence="17">4.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MLYCD</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonyl-CoA + H(+) = acetyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:18781"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="EC" id="4.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:18782"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.9" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A096NF03"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011491"/>
    <dbReference type="Ensembl" id="ENSPANT00000008948.3">
        <property type="protein sequence ID" value="ENSPANP00000011491.2"/>
        <property type="gene ID" value="ENSPANG00000010882.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005410"/>
    <dbReference type="HOGENOM" id="CLU_023433_0_0_1"/>
    <dbReference type="OMA" id="PIDWSTP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010882">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046321">
        <property type="term" value="P:positive regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.90:FF:000001">
        <property type="entry name" value="Malonyl-CoA decarboxylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.150:FF:000001">
        <property type="entry name" value="Malonyl-CoA decarboxylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.90">
        <property type="entry name" value="Malonyl-CoA decarboxylase, oligemerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase N-terminal" evidence="20">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="19">
        <location>
            <begin position="221"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011491.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="521" mass="57805" checksum="BFACC2A17F341E9A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NF52</accession>
    <name>A0A096NF52_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Jade family PHD finger 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">JADE3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the JADE family.</text>
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        <property type="nucleotide sequence ID" value="XM_003917624.5"/>
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    <dbReference type="RefSeq" id="XP_009195740.1">
        <property type="nucleotide sequence ID" value="XM_009197476.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809290.1">
        <property type="nucleotide sequence ID" value="XM_017953801.3"/>
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    <dbReference type="RefSeq" id="XP_017809291.1">
        <property type="nucleotide sequence ID" value="XM_017953802.2"/>
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        <property type="nucleotide sequence ID" value="XM_021932959.2"/>
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        <property type="protein sequence ID" value="ENSPANP00000011541.1"/>
        <property type="gene ID" value="ENSPANG00000016120.3"/>
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        <property type="component" value="Chromosome X"/>
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        <property type="expression patterns" value="Expressed in testis and 61 other cell types or tissues"/>
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        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="term" value="P:regulation of DNA biosynthetic process"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Protein Jade-1 isoform 1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Enhancer_polycomb-like_N"/>
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        <property type="entry name" value="Histone_Mod_Regulator"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="PHD FINGER PROTEINS"/>
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        <property type="entry name" value="PROTEIN JADE-3"/>
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        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="252"/>
            <end position="366"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="587"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="609"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
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            <begin position="8"/>
            <end position="25"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="650"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="673"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00038371"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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        <source>
            <dbReference type="PROSITE" id="PS51805"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011541.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="823" mass="93805" checksum="D72BDB8FA3FDF77B" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NH57</accession>
    <name>A0A096NH57_PAPAN</name>
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        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096NH57"/>
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        <property type="protein sequence ID" value="ENSPANP00000012305.3"/>
        <property type="gene ID" value="ENSPANG00000021601.4"/>
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    <dbReference type="eggNOG" id="KOG2422">
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        <property type="component" value="Chromosome 18"/>
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    <dbReference type="Bgee" id="ENSPANG00000021601">
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:RQC complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="388"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012305.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49380" checksum="9C884981DCE0F3CA" modified="2022-05-25" version="3">MRLLESRKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPENRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPEHERSSAREKASLLIQQALTMFPGGGCRIWPGVGVLSSPSQPLPAAQAGELCTSGGHLWKEHTPMSWLGSVMGSADCGPGTLRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPERRERNSVTWESQLCVCRPRSFPSPLNARVLACQPLYSPVQTCPIAAGGEARGRSGWGSEPQPGPEQADAGCARHDGQLPPQRPRVPRPGCTSSLNLLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHE1</accession>
    <name>A0A096NHE1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PSMB8</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP. Interacts with TAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NHE1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012389"/>
    <dbReference type="MEROPS" id="T01.012"/>
    <dbReference type="Ensembl" id="ENSPANT00000007527.3">
        <property type="protein sequence ID" value="ENSPANP00000012389.3"/>
        <property type="gene ID" value="ENSPANG00000016588.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157293"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016588">
        <property type="expression patterns" value="Expressed in spleen and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NHE1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990111">
        <property type="term" value="C:spermatoproteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000038">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF8">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012389.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="276" mass="30339" checksum="5966037BD67FAE0F" modified="2022-05-25" version="3">MALLDVCGAPRGQRPEWALPVSGSGHRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGEGNVQIDMAHGTTTLAFKFQHGVIVAVDSRASAGSYIATLRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGDRISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAHATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIW1</accession>
    <name>A0A096NIW1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Receptor-interacting serine/threonine-protein kinase 4</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Ankyrin repeat domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">RIPK4</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Serine/threonine protein kinase. Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with PRKCB. Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_021791190.2">
        <property type="nucleotide sequence ID" value="XM_021935498.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NIW1"/>
    <dbReference type="SMR" id="A0A096NIW1"/>
    <dbReference type="Ensembl" id="ENSPANT00000011360.3">
        <property type="protein sequence ID" value="ENSPANP00000012909.3"/>
        <property type="gene ID" value="ENSPANG00000022205.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023465"/>
    <dbReference type="KEGG" id="panu:101023465"/>
    <dbReference type="CTD" id="54101"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159908"/>
    <dbReference type="HOGENOM" id="CLU_000288_7_35_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022205">
        <property type="expression patterns" value="Expressed in cornea and 25 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NIW1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14025">
        <property type="entry name" value="STKc_RIP4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000440">
        <property type="entry name" value="Receptor interacting serine/threonine kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000288">
        <property type="entry name" value="Receptor-interacting serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000260">
        <property type="entry name" value="Receptor-interacting serine/threonine-protein kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF65">
        <property type="entry name" value="RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00059729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00071067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012909.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="786" mass="86673" checksum="92BDC3866D8310D0" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NK74</accession>
    <name>A0A096NK74_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 83 member F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM83F</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM83 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905623.2">
        <property type="nucleotide sequence ID" value="XM_003905574.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NK74"/>
    <dbReference type="Ensembl" id="ENSPANT00000024316.3">
        <property type="protein sequence ID" value="ENSPANP00000013379.2"/>
        <property type="gene ID" value="ENSPANG00000016392.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016707"/>
    <dbReference type="KEGG" id="panu:101016707"/>
    <dbReference type="CTD" id="113828"/>
    <dbReference type="eggNOG" id="ENOG502QPW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160998"/>
    <dbReference type="HOGENOM" id="CLU_019056_2_0_1"/>
    <dbReference type="OMA" id="HVEMFDI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016392">
        <property type="expression patterns" value="Expressed in esophagus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050944">
        <property type="entry name" value="FAM83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012461">
        <property type="entry name" value="SACK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16181">
        <property type="entry name" value="PROTEIN FAM83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16181:SF29">
        <property type="entry name" value="PROTEIN FAM83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07894">
        <property type="entry name" value="SACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffolding anchor of CK1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013379.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="501" mass="55606" checksum="D5B27C28E163CDB7" modified="2022-05-25" version="2">MAESQLNCLDEAHVNEKVTEAQAAFYYCERRRAALEALLGGGEQAYRERLKEQQLRDFLSSPERQALRASWSPYEDAAPAANARGKSKAKAKAPAPAPAESGESLAYWPDRSDTEVPPLDLGWTDTGFYRGVSRVTLFTHPPKDEKAPHLKQVVRQMIQQAQKVIAVVMDLFTDGDIFQDIVDVACKRRVPVYIILDEAGVKYFLEMCQDLQLTDFRIRNIRVRSVTGVGFYMPMGRIKGTLSSRFLMVDGDKVATGSYRFTWSSSYVDRNLLLLLTGQNVEPFDTEFRELYAISEEVDLYRQLGLAGRIGLHYSSTVARKLINPKYALVSGCRHPPGEMMRWAARQQREAGGNPEGQEDGGSGGESARRLESFLRDLVTVEQMLPPVEPIPLGELSRKDGKMVSHTHRDLKPKSREAPSQNGIGEAARGETAPARRFSSRLFSRRAKRPTAPNGMASSVSTETVPEVEFLTGKRPNENSSADISGKTSPSSAKPSNCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNW4</accession>
    <name>A0A096NNW4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Procollagen C-endopeptidase enhancer 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Procollagen COOH-terminal proteinase enhancer 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Type 1 procollagen C-proteinase enhancer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Type I procollagen COOH-terminal proteinase enhancer</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PCOLCE</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with EFEMP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NNW4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014674"/>
    <dbReference type="Ensembl" id="ENSPANT00000021937.3">
        <property type="protein sequence ID" value="ENSPANP00000014674.3"/>
        <property type="gene ID" value="ENSPANG00000018315.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159264"/>
    <dbReference type="HOGENOM" id="CLU_034096_0_0_1"/>
    <dbReference type="OMA" id="GIMKCED"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018315">
        <property type="expression patterns" value="Expressed in supraoptic nucleus and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03576">
        <property type="entry name" value="NTR_PCOLCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000019">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000026">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035814">
        <property type="entry name" value="NTR_PCOLCE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF24">
        <property type="entry name" value="PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035181952" description="Procollagen C-endopeptidase enhancer 1" evidence="16">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="159"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="18">
        <location>
            <begin position="320"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014674.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="451" mass="48353" checksum="F8898BF71031A723" modified="2022-05-25" version="3">MLPAATASLLGPLLTAWALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTADEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPRDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPSPKPGTEPKVKPPRKSQPPEKTEETPSAPDAPAVTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSLIGAYKTGGLDLPSPPTGTSLKFYVPCKQCPPLKKGVSYLLMGQVEENRGPVLPPESFVVLHRPNQDQILTNLSKRKCPSQPVRAAESQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPJ5</accession>
    <name>A0A096NPJ5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NDUFB11</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917676.1">
        <property type="nucleotide sequence ID" value="XM_003917627.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NPJ5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014925"/>
    <dbReference type="Ensembl" id="ENSPANT00000029264.3">
        <property type="protein sequence ID" value="ENSPANP00000014925.3"/>
        <property type="gene ID" value="ENSPANG00000010725.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014764"/>
    <dbReference type="KEGG" id="panu:101014764"/>
    <dbReference type="CTD" id="54539"/>
    <dbReference type="eggNOG" id="KOG4808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003022"/>
    <dbReference type="HOGENOM" id="CLU_109862_0_0_1"/>
    <dbReference type="OMA" id="DYRMKEW"/>
    <dbReference type="OrthoDB" id="5917019at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010725">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014925.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="219" mass="24847" checksum="D57DC41645AA632D" modified="2022-05-25" version="3">MVGPTKPRQLEAKRVAQRPASLENKIRSGTYIAWRRRSDNCRALTHCSCAQSHFRPRPSDPAAPSVMAAGLFGLSARRLLAAAATRGLPAARVRWESSFSRTVVAPSAVARKRAPEPTTQWQEDPEPEHENLYETNPDSHGYDKDPVLDVWNMRVVFFFGVSVVLVLGSTYVAYLPDYRMKEWSRREAERLVKYREANGLPLMESNYFDPSKIQLPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQS5</accession>
    <name>A0A096NQS5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC20A2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71259"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902749.1">
        <property type="nucleotide sequence ID" value="XM_003902700.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211244.1">
        <property type="nucleotide sequence ID" value="XM_009212980.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211245.1">
        <property type="nucleotide sequence ID" value="XM_009212981.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211246.1">
        <property type="nucleotide sequence ID" value="XM_009212982.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211247.1">
        <property type="nucleotide sequence ID" value="XM_009212983.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211248.1">
        <property type="nucleotide sequence ID" value="XM_009212984.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQS5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015389"/>
    <dbReference type="Ensembl" id="ENSPANT00000007872.3">
        <property type="protein sequence ID" value="ENSPANP00000015389.1"/>
        <property type="gene ID" value="ENSPANG00000015058.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020015"/>
    <dbReference type="KEGG" id="panu:101020015"/>
    <dbReference type="CTD" id="6575"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014879"/>
    <dbReference type="HOGENOM" id="CLU_015355_3_1_1"/>
    <dbReference type="OMA" id="MQAFCIA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015058">
        <property type="expression patterns" value="Expressed in gastrocnemius and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQS5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF83">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="652" mass="70448" checksum="EC7F8D6E30149D7A" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSH7</accession>
    <name>A0A096NSH7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tyrosine aminotransferase</fullName>
            <shortName evidence="13">TAT</shortName>
            <ecNumber evidence="5 13">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TAT</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_009195091.2">
        <property type="nucleotide sequence ID" value="XM_009196827.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NSH7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015998"/>
    <dbReference type="Ensembl" id="ENSPANT00000022192.3">
        <property type="protein sequence ID" value="ENSPANP00000015998.3"/>
        <property type="gene ID" value="ENSPANG00000018042.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026794"/>
    <dbReference type="CTD" id="6898"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156704"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_1"/>
    <dbReference type="OMA" id="CALDLCI"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018042">
        <property type="expression patterns" value="Expressed in liver and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000048">
        <property type="entry name" value="tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000040">
        <property type="entry name" value="Tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011715">
        <property type="entry name" value="Tyr_aminoTrfase_ubiquitination"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07706">
        <property type="entry name" value="TAT_ubiq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="72"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015998.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="455" mass="50554" checksum="E37E0EA9968EB8E9" modified="2022-05-25" version="3">MDPYVIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRNTRWSVRPSDMANKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIEMCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPVLSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLAKLSQRILGPCTIVQGALKSILRRTPEEFYHNTLSFLKSSADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATQCFEYPNFIRVVITVPKVMMLEACSRIQEFCEQHYHCAEGSQEECDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTH6</accession>
    <name>A0A096NTH6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HGS</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Early endosome membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endosome</location>
            <location evidence="8">Multivesicular body membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003913612.1">
        <property type="nucleotide sequence ID" value="XM_003913563.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NTH6"/>
    <dbReference type="Ensembl" id="ENSPANT00000010459.3">
        <property type="protein sequence ID" value="ENSPANP00000016347.1"/>
        <property type="gene ID" value="ENSPANG00000019330.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000472"/>
    <dbReference type="KEGG" id="panu:101000472"/>
    <dbReference type="CTD" id="9146"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158297"/>
    <dbReference type="HOGENOM" id="CLU_013062_1_0_1"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019330">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NTH6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FYVE_Hrs"/>
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    <dbReference type="CDD" id="cd21387">
        <property type="entry name" value="GAT_Hrs"/>
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        <property type="entry name" value="Putative hepatocyte growth factor-regulated tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH_VHS"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="13">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="319"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="406"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="718"/>
            <end position="777"/>
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    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="470"/>
            <end position="553"/>
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        <location>
            <begin position="290"/>
            <end position="311"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="777" mass="86044" checksum="2E58DE8088BEF58E" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTR0</accession>
    <name>A0A096NTR0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031657204.1"/>
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        <property type="nucleotide sequence ID" value="XM_031657205.1"/>
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    <dbReference type="RefSeq" id="XP_031513066.1">
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        <property type="protein sequence ID" value="ENSPANP00000016431.3"/>
        <property type="gene ID" value="ENSPANG00000018709.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018709">
        <property type="expression patterns" value="Expressed in amygdala and 62 other cell types or tissues"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016431.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="218" mass="25135" checksum="05E0EE8BA08DB82E" modified="2022-05-25" version="3">MPTWFCSRAWFSHVGPFDEGGQGVPEDLLFFYEHLRKGGGVIRVNQSLLLYRYHPRAATHSVLETTIWTHRVRFLEEQALPRWAAFTIWNAGKQGRRLYRSLTAASQRKVVAFCDVDENKIRKGFYCHEDSQERPKPRIPILHFRAARPPFVICVKLKHLVLTVLFKTVSTRTGLAWSLNSGVSFANSRETREEGQIAAERVEMFSRQDGFHSSDSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUL0</accession>
    <name>A0A096NUL0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPP2R3C</name>
    </gene>
    <organism evidence="11 12">
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        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003901749.1">
        <property type="nucleotide sequence ID" value="XM_003901700.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUL0"/>
    <dbReference type="SMR" id="A0A096NUL0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016734"/>
    <dbReference type="Ensembl" id="ENSPANT00000015225.3">
        <property type="protein sequence ID" value="ENSPANP00000016734.2"/>
        <property type="gene ID" value="ENSPANG00000024268.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020710"/>
    <dbReference type="KEGG" id="panu:101020710"/>
    <dbReference type="CTD" id="55012"/>
    <dbReference type="eggNOG" id="KOG2562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155583"/>
    <dbReference type="HOGENOM" id="CLU_035365_1_0_1"/>
    <dbReference type="OMA" id="HKFWAYE"/>
    <dbReference type="OrthoDB" id="10265007at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024268">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUL0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045579">
        <property type="term" value="P:positive regulation of B cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002759">
        <property type="term" value="P:regulation of antimicrobial humoral response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051900">
        <property type="term" value="P:regulation of mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21505">
        <property type="entry name" value="PPP2R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000091">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PP2A regulatory subunit B'' EF-hand" evidence="10">
        <location>
            <begin position="182"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016734.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="453" mass="53399" checksum="78EA66063C396B33" modified="2018-02-28" version="2">MDWKEVLRRRLATPNTRPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDSENSTDLDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWI2</accession>
    <name>A0A096NWI2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-associating and dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RADIL</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family. Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RADIL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895727.1">
        <property type="nucleotide sequence ID" value="XM_003895678.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009200803.1">
        <property type="nucleotide sequence ID" value="XM_009202539.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWI2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017410"/>
    <dbReference type="Ensembl" id="ENSPANT00000026886.3">
        <property type="protein sequence ID" value="ENSPANP00000017410.1"/>
        <property type="gene ID" value="ENSPANG00000019579.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019121"/>
    <dbReference type="KEGG" id="panu:101019121"/>
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    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159293"/>
    <dbReference type="HOGENOM" id="CLU_010386_0_0_1"/>
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    <dbReference type="OrthoDB" id="3908708at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Bgee" id="ENSPANG00000019579">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 26 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
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        <property type="term" value="C:protein-containing complex"/>
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        <property type="term" value="F:GTPase binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
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    <dbReference type="CDD" id="cd15472">
        <property type="entry name" value="Myo5p-like_CBD_Rasip1"/>
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        <property type="entry name" value="PDZ_Radil-like"/>
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        <property type="entry name" value="RA_Radil_like"/>
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    <dbReference type="FunFam" id="2.30.42.10:FF:000156">
        <property type="entry name" value="Ras-associating and dilute domain-containing protein"/>
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        <property type="entry name" value="ras-associating and dilute domain-containing protein"/>
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        <property type="entry name" value="Ras-associating and dilute domain-containing protein"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="entry name" value="CBD_Rasip1/Radil"/>
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        <property type="entry name" value="FHA_dom"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
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    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF3">
        <property type="entry name" value="RAS-ASSOCIATING AND DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="10">
        <location>
            <begin position="61"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="497"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="814"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117101" checksum="E99302FA7DF84E8D" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXS3</accession>
    <name>A0A096NXS3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Adhesion G-protein coupled receptor G7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">G-protein coupled receptor 128</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ADGRG7</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Orphan receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009197463.2">
        <property type="nucleotide sequence ID" value="XM_009199199.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXS3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017875"/>
    <dbReference type="Ensembl" id="ENSPANT00000021530.4">
        <property type="protein sequence ID" value="ENSPANP00000017875.1"/>
        <property type="gene ID" value="ENSPANG00000006084.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100999527"/>
    <dbReference type="KEGG" id="panu:100999527"/>
    <dbReference type="CTD" id="84873"/>
    <dbReference type="GeneTree" id="ENSGT00940000159169"/>
    <dbReference type="HOGENOM" id="CLU_370321_0_0_1"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006084">
        <property type="expression patterns" value="Expressed in ileum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NXS3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15257">
        <property type="entry name" value="7tmB2_GPR128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000256">
        <property type="entry name" value="Adhesion G protein-coupled receptor G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000025">
        <property type="entry name" value="Adhesion G protein-coupled receptor G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047938">
        <property type="entry name" value="GPR128_7tmB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053985">
        <property type="entry name" value="GPR128_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053986">
        <property type="entry name" value="GPR128_GAIN_subdom_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053984">
        <property type="entry name" value="GPR128_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22261">
        <property type="entry name" value="GPR128_GAIN_subdom_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22259">
        <property type="entry name" value="GPR128_GAIN_subdomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22257">
        <property type="entry name" value="GPR128_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="17">
        <location>
            <begin position="275"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="434"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="796" mass="88653" checksum="F03CB7FA88EC1230" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXV9</accession>
    <name>A0A096NXV9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Krueppel-like factor 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KLF7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with FBXO38.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907914.1">
        <property type="nucleotide sequence ID" value="XM_003907865.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXV9"/>
    <dbReference type="SMR" id="A0A096NXV9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017915"/>
    <dbReference type="Ensembl" id="ENSPANT00000009169.3">
        <property type="protein sequence ID" value="ENSPANP00000017915.1"/>
        <property type="gene ID" value="ENSPANG00000005240.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008791"/>
    <dbReference type="KEGG" id="panu:101008791"/>
    <dbReference type="CTD" id="8609"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155235"/>
    <dbReference type="HOGENOM" id="CLU_002678_33_4_1"/>
    <dbReference type="OMA" id="DCFLHAA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005240">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904178">
        <property type="term" value="P:negative regulation of adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061179">
        <property type="term" value="P:negative regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045604">
        <property type="term" value="P:regulation of epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21585">
        <property type="entry name" value="KLF7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001395">
        <property type="entry name" value="Krueppel-like factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF77">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="302" mass="33362" checksum="95141CE3A42C5774" modified="2014-11-26" version="1">MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEAAICEKSSAVDILLSRDKLLSETCLSLQPASSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGGVATAAAAVTAAGAVKSGQSDSDQGGLGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZK7</accession>
    <name>A0A096NZK7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PDK1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003907662.1">
        <property type="nucleotide sequence ID" value="XM_003907613.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZK7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018528"/>
    <dbReference type="Ensembl" id="ENSPANT00000007659.3">
        <property type="protein sequence ID" value="ENSPANP00000018528.1"/>
        <property type="gene ID" value="ENSPANG00000018423.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026361"/>
    <dbReference type="KEGG" id="panu:101026361"/>
    <dbReference type="CTD" id="5163"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234646"/>
    <dbReference type="HOGENOM" id="CLU_023861_1_1_1"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018423">
        <property type="expression patterns" value="Expressed in heart and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZK7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097411">
        <property type="term" value="P:hypoxia-inducible factor-1alpha signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008631">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010510">
        <property type="term" value="P:regulation of pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF14">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="270"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="436" mass="49120" checksum="CA0E2B373E34872F" modified="2014-11-26" version="1">MRLARLLRGAALAVPGPGLRAAGPSRSFSSDSGSGPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVVEVIKDGYENARRLCDLYYINSPELELGELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZU5</accession>
    <name>A0A096NZU5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vitamin K-dependent gamma-carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Gamma-glutamyl carboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidyl-glutamate 4-carboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Vitamin K gamma glutamyl carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GGCX</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-carboxy-L-glutamyl-[protein] + 2,3-epoxyphylloquinone + H2O + H(+) = phylloquinol + L-glutamyl-[protein] + CO2 + O2</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="RmlC-like cupins"/>
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    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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        <source>
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    <sequence length="758" mass="87438" checksum="6823C592EE18DC61" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZY0</accession>
    <name>A0A096NZY0_PAPAN</name>
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        <recommendedName>
            <fullName evidence="12">Small ribosomal subunit protein mS39</fullName>
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        <alternativeName>
            <fullName evidence="14">28S ribosomal protein S39, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="15">Pentatricopeptide repeat domain-containing protein 3, mitochondrial</fullName>
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    </protein>
    <gene>
        <name evidence="18" type="primary">PTCD3</name>
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    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial RNA-binding protein that has a role in mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908970.2">
        <property type="nucleotide sequence ID" value="XM_003908921.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZY0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018655"/>
    <dbReference type="Ensembl" id="ENSPANT00000022741.3">
        <property type="protein sequence ID" value="ENSPANP00000018655.3"/>
        <property type="gene ID" value="ENSPANG00000009006.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026374"/>
    <dbReference type="KEGG" id="panu:101026374"/>
    <dbReference type="CTD" id="55037"/>
    <dbReference type="eggNOG" id="KOG4422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016876"/>
    <dbReference type="HOGENOM" id="CLU_026264_0_1_1"/>
    <dbReference type="OMA" id="FMHQEAQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009006">
        <property type="expression patterns" value="Expressed in heart and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZY0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000420">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000457">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="16">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018655.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="689" mass="78554" checksum="9B8E9BA5743AB59E" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2J2</accession>
    <name>A0A096P2J2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inhibitor of CDK, cyclin A1 interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">INCA1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009187705.1">
        <property type="nucleotide sequence ID" value="XM_009189441.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009187706.1">
        <property type="nucleotide sequence ID" value="XM_009189442.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009187708.1">
        <property type="nucleotide sequence ID" value="XM_009189444.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2J2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019567"/>
    <dbReference type="Ensembl" id="ENSPANT00000023561.3">
        <property type="protein sequence ID" value="ENSPANP00000019567.1"/>
        <property type="gene ID" value="ENSPANG00000024318.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025944"/>
    <dbReference type="CTD" id="388324"/>
    <dbReference type="eggNOG" id="ENOG502SX61">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000242"/>
    <dbReference type="HOGENOM" id="CLU_103802_0_0_1"/>
    <dbReference type="OMA" id="WGMELES"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024318">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048147">
        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026238">
        <property type="entry name" value="INCA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37341">
        <property type="entry name" value="PROTEIN INCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37341:SF1">
        <property type="entry name" value="PROTEIN INCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15142">
        <property type="entry name" value="INCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02102">
        <property type="entry name" value="PROTEININCA1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="236" mass="26722" checksum="DE41EC8DEF80B4F7" modified="2014-11-26" version="1">MQVQDDGGNLIPFAKCSRVVSRSPPPRLPSQSLRLMPQRYGDVFWKNLSQRPSLTWLEEQHIPPMLRATGCSQLGLYPPEQLPPPEMLWRRKKRRPCLERMQQQGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGTASEPVVLGEEGCGFPSTNEYPDLEEERATYPQEENSFLTPGRAQLLWSPWSPLGQEAACASRQLHTLASFSTVTARRNPLHNPWGMQLAASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3V9</accession>
    <name>A0A096P3V9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type III domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FNDC8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003912663.2">
        <property type="nucleotide sequence ID" value="XM_003912614.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P3V9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020034"/>
    <dbReference type="Ensembl" id="ENSPANT00000020585.3">
        <property type="protein sequence ID" value="ENSPANP00000020034.2"/>
        <property type="gene ID" value="ENSPANG00000022990.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013907"/>
    <dbReference type="KEGG" id="panu:101013907"/>
    <dbReference type="CTD" id="54752"/>
    <dbReference type="eggNOG" id="ENOG502STU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006458"/>
    <dbReference type="HOGENOM" id="CLU_075088_0_0_1"/>
    <dbReference type="OMA" id="TYAVGKQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022990">
        <property type="expression patterns" value="Expressed in testis and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002100">
        <property type="entry name" value="Fibronectin type III domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32430">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32430:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="179"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00068338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020034.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="324" mass="35953" checksum="11787691B0495AFE" modified="2022-05-25" version="2">MASEALHQVGDGEEAVLKKENFNMMNALDQLPKPFPNPKSMNRTVTTKGLPLSSKGNLVNFLEDDTINLPKPMPVDDSDCSSDDTSISAFSSTLLNPIKLAVTQPNSSFFAGMLEGELNKLSFSPMAKNTEKEDLALGPCPCPSKCQMATRGLLDLDNPELETETSSTHSESSVVVDLPDTPFIFEHTVSNSTAVISWTYALGKQPVSFYQVLLQEAAETQENELPKAKNRPWIFNKILGTTVKLMELKPNTCYCLTVRAANTAGVGKWCKPYKFATLATDFSSFPENNPIQITVRRKEPQRKIVSIGLEEMRRLEDLEYLFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P466</accession>
    <name>A0A096P466_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCNY</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin Y subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003903599.1">
        <property type="nucleotide sequence ID" value="XM_003903550.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P466"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020141"/>
    <dbReference type="Ensembl" id="ENSPANT00000019585.3">
        <property type="protein sequence ID" value="ENSPANP00000020141.1"/>
        <property type="gene ID" value="ENSPANG00000022745.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011329"/>
    <dbReference type="KEGG" id="panu:101011329"/>
    <dbReference type="CTD" id="219771"/>
    <dbReference type="eggNOG" id="KOG1675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154453"/>
    <dbReference type="HOGENOM" id="CLU_055026_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022745">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P466">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000011">
        <property type="entry name" value="Cyclin-Y isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="173"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="341" mass="39351" checksum="949FDE1AB5193C6E" modified="2014-11-26" version="1">MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAITRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4M1</accession>
    <name>A0A096P4M1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FUT11</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 16">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A096P4M1"/>
    <dbReference type="Ensembl" id="ENSPANT00000018347.3">
        <property type="protein sequence ID" value="ENSPANP00000020296.3"/>
        <property type="gene ID" value="ENSPANG00000022452.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158983"/>
    <dbReference type="HOGENOM" id="CLU_032075_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022452">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P4M1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017176">
        <property type="entry name" value="Alpha-1_3-FUT_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF198">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037332">
        <property type="entry name" value="Alpha1_3FUT_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 15 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035230129" description="GDP-fucose protein O-fucosyltransferase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="19">
        <location>
            <begin position="77"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="18">
        <location>
            <begin position="213"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020296.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="476" mass="53419" checksum="74C3E60BC3556030" modified="2022-05-25" version="3">MAAGPTGAVLALLGVLSVCAARAYGSVAEREAGGEAEWAEPWDGAVFRPPSALGAVGVTRSSGTPRPGREEAGDLPVLLWWSPGLFPHFPGDSERIECARGACVTSRNRRALRDSRTRALLFYGTDFRASAAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTSTFSRHSDYPLSLQWLPGTAYLRRPVPPLRERAEWRRRGYAPLLYLQSHCDVPADRDRYVRELMRHIPVDSYGKCLQNRELPTARLQDTATATTEDPELLAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDSLKHREWGVNDPLLPNYLNGFECFVCDHELARLDAEKAHAASPGDSPVLEPHIAQPSHMDCPVPTPGFGNVEEIPENDSSLVQVRDHCICLRCLWPHSEKGRTHNYAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5B9</accession>
    <name>A0A096P5B9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuronal differentiation 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NEUROD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="416" mass="44625" checksum="2B17F559895889AD" modified="2022-05-25" version="3">MPCCFSPHRPEPAPGAGDSSARGDDPPASGIGGTMLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGASGPARAAKPVPLRGEEGPEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MU10</accession>
    <name>A0A0A0MU10_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Junctional sarcoplasmic reticulum protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">JSRP1</name>
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    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MU10"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000423"/>
    <dbReference type="Ensembl" id="ENSPANT00000003190.3">
        <property type="protein sequence ID" value="ENSPANP00000000423.3"/>
        <property type="gene ID" value="ENSPANG00000001000.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4JK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012911"/>
    <dbReference type="HOGENOM" id="CLU_073497_0_0_1"/>
    <dbReference type="OMA" id="QELPWGD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001000">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026178">
        <property type="entry name" value="JSRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22397">
        <property type="entry name" value="JUNCTIONAL SARCOPLASMIC RETICULUM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22397:SF2">
        <property type="entry name" value="JUNCTIONAL SARCOPLASMIC RETICULUM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15312">
        <property type="entry name" value="JSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000423.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="333" mass="36304" checksum="FCC43D8ACB78DF65" modified="2022-05-25" version="3">ISMATSAWEELDGGLGSCQALEDHSALAEPQEDRAPATPRLADSGSPPHDSREPVAEGCSVDTRPKKMEKEAAARGTPGTGKERLKAGASPRSAPARKKAQTAPPAQPPPQPPALSQELPWGDLSLNKCLVLASLVALLGSAFQLCRDAVAGEAAVQARAPEPWVPPSSAPREPSSPLPKFEAQAPPSALPAPRTEAEIRPKIPGSREAAEKDEEEPGEATGEAAGEDRAPLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPRRWESREGGHRPWARDSRDAEPRKRQAWVSPRRPDEEERPGSRQKLRAGKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVE1</accession>
    <name>A0A0A0MVE1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM205 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003914966.1">
        <property type="nucleotide sequence ID" value="XM_003914917.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003914967.1">
        <property type="nucleotide sequence ID" value="XM_003914918.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003914968.1">
        <property type="nucleotide sequence ID" value="XM_003914919.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191795.1">
        <property type="nucleotide sequence ID" value="XM_009193531.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191798.1">
        <property type="nucleotide sequence ID" value="XM_009193534.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191799.1">
        <property type="nucleotide sequence ID" value="XM_009193535.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVE1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006071"/>
    <dbReference type="Ensembl" id="ENSPANT00000023252.3">
        <property type="protein sequence ID" value="ENSPANP00000006071.1"/>
        <property type="gene ID" value="ENSPANG00000011041.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006952"/>
    <dbReference type="KEGG" id="panu:101006952"/>
    <dbReference type="CTD" id="374882"/>
    <dbReference type="eggNOG" id="KOG2886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016298"/>
    <dbReference type="HOGENOM" id="CLU_094297_1_1_1"/>
    <dbReference type="OMA" id="FQMRAVE"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011041">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042623">
        <property type="entry name" value="TMEM205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46916">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46916:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="8">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="189" mass="21140" checksum="5D95DC2E4071D8B0" modified="2015-01-07" version="1">MEEGGNLGGLIKMVHLLVLSGAWGMQMWVTFVSGFLLFRGLPRHTFGLAQSKLFPFYFHISMGCAFINLCILASQHAWAQLTFWEASQLYLLFLSLTLATVNARWLEPRTTAAMWALQTVEKERGLGGEVPGSHQGPDPYRQLREKDPKYSALRQNFFRYHGLSSLCNLGCVLSNGLCLAGLALEIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LDZ1</accession>
    <name>A0A2I3LDZ1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-gated purine nucleotide uniporter SLC17A9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 17 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Vesicular nucleotide transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC17A9</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles. By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles. Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) = ADP(out)</text>
            <dbReference type="Rhea" id="RHEA:75783"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP(in) = ATP(out)</text>
            <dbReference type="Rhea" id="RHEA:75687"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP(in) = GTP(out)</text>
            <dbReference type="Rhea" id="RHEA:75787"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle</location>
            <location evidence="9">Chromaffin granule membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031512763.1">
        <property type="nucleotide sequence ID" value="XM_031656903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LDZ1"/>
    <dbReference type="Ensembl" id="ENSPANT00000034698.2">
        <property type="protein sequence ID" value="ENSPANP00000021693.2"/>
        <property type="gene ID" value="ENSPANG00000011749.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018713"/>
    <dbReference type="KEGG" id="panu:101018713"/>
    <dbReference type="CTD" id="63910"/>
    <dbReference type="GeneTree" id="ENSGT00940000158186"/>
    <dbReference type="OMA" id="LITFWMP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011749">
        <property type="expression patterns" value="Expressed in aorta and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098594">
        <property type="term" value="C:mucin granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160042">
        <property type="term" value="F:purine nucleotide uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141013">
        <property type="term" value="P:purine nucleotide import into lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000150">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="26"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021693.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="436" mass="47243" checksum="C1E0862647D54588" modified="2022-05-25" version="2">MQPTPDEARRDRAGDSQWSRPECQAWTGTLLLGTCLLYCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAQLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRDSERAFTYSTVGAGSQFGTLLTGAVGSLLLEWYGWQSVFYFSGGLTLLWVWYVYRYLLSGKDLVLALGVLAQGLPVSRHSRVPWRRLFRKPAVWAAVISQLSAACSFFVLISWLPTFFKETFPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLIETTGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LIG4</accession>
    <name>A0A2I3LIG4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein EFR3 homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein EFR3-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EFR3A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LIG4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000023231"/>
    <dbReference type="Ensembl" id="ENSPANT00000046767.2">
        <property type="protein sequence ID" value="ENSPANP00000023231.1"/>
        <property type="gene ID" value="ENSPANG00000006815.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006815">
        <property type="expression patterns" value="Expressed in testis and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LIG4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000347">
        <property type="entry name" value="EFR3 homolog A (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF1">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="848" mass="96075" checksum="65168BC210466171" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LIZ9</accession>
    <name>A0A2I3LIZ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RTN3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009184056.2">
        <property type="nucleotide sequence ID" value="XM_009185792.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LIZ9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000023420"/>
    <dbReference type="Ensembl" id="ENSPANT00000039998.2">
        <property type="protein sequence ID" value="ENSPANP00000023420.2"/>
        <property type="gene ID" value="ENSPANG00000004686.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024275"/>
    <dbReference type="CTD" id="10313"/>
    <dbReference type="GeneTree" id="ENSGT00940000157482"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004686">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LIZ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902430">
        <property type="term" value="P:negative regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2480:FF:000001">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF4">
        <property type="entry name" value="RETICULON-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="842"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU210713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023420.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112392" checksum="5EFDB7E3B26C5025" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LJI9</accession>
    <name>A0A2I3LJI9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="17">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FKBP8</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
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            <dbReference type="EC" id="5.2.1.8"/>
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    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Mitochondrion membrane</location>
            <topology evidence="16">Single-pass membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LLV5</accession>
    <name>A0A2I3LLV5_PAPAN</name>
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        <recommendedName>
            <fullName evidence="9">Motile sperm domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
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        <name evidence="14" type="primary">MOSPD2</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooligomer. Interacts (via MSP domain) with STARD3NL (via FFAT motif), RMDN3 (via FFAT motif), OSBPL1A (via FFAT motif) and CERT1 (via FFAT motif). Interacts (via MSP domain) with STARD3 (via phosphorylated FFAT motif); this interaction depends on the critical phosphorylation of STARD3 on 'Ser-209'. Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif) and OSBPL1A (via FFAT motif).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LLV5"/>
    <dbReference type="Ensembl" id="ENSPANT00000050690.2">
        <property type="protein sequence ID" value="ENSPANP00000024414.2"/>
        <property type="gene ID" value="ENSPANG00000012515.3"/>
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    <dbReference type="GeneTree" id="ENSGT00390000016713"/>
    <dbReference type="OMA" id="NDALKCW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012515">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LLV5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090023">
        <property type="term" value="P:positive regulation of neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000010">
        <property type="entry name" value="motile sperm domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000586">
        <property type="entry name" value="motile sperm domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="12">
        <location>
            <begin position="84"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="13">
        <location>
            <begin position="329"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024414.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="520" mass="59985" checksum="13CEB757D525F2BC" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LSS5</accession>
    <name>A0A2I3LSS5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small integral membrane protein 10 like 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SMIM10L2A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LSS5"/>
    <dbReference type="SMR" id="A0A2I3LSS5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000026482"/>
    <dbReference type="Ensembl" id="ENSPANT00000057858.2">
        <property type="protein sequence ID" value="ENSPANP00000026482.1"/>
        <property type="gene ID" value="ENSPANG00000050936.1"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:100999222"/>
    <dbReference type="GeneTree" id="ENSGT00390000014547"/>
    <dbReference type="OMA" id="VMFNVRL"/>
    <dbReference type="OrthoDB" id="9619930at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031657">
        <property type="expression patterns" value="Expressed in amygdala and 41 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029367">
        <property type="entry name" value="SMIM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34446">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34446:SF3">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15118">
        <property type="entry name" value="DUF4560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="78" mass="8389" checksum="45160CC3A2FBB8C1" modified="2018-02-28" version="1">MAASAALSAAAAAAALSGLAVRLSRSAAARGSYGAFCKGLTRTLLTFFDLAWRLRMNFPYFYIVASVMLNVRLQVRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LT66</accession>
    <name>A0A2I3LT66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
            <shortName evidence="2">SF3b5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SF3B5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898132.1">
        <property type="nucleotide sequence ID" value="XM_003898083.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LT66"/>
    <dbReference type="SMR" id="A0A2I3LT66"/>
    <dbReference type="STRING" id="9555.ENSPANP00000026627"/>
    <dbReference type="Ensembl" id="ENSPANT00000051746.2">
        <property type="protein sequence ID" value="ENSPANP00000026627.1"/>
        <property type="gene ID" value="ENSPANG00000034242.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101009289"/>
    <dbReference type="KEGG" id="panu:101009289"/>
    <dbReference type="CTD" id="83443"/>
    <dbReference type="GeneTree" id="ENSGT00390000013215"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034242">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <feature type="site" description="Interaction with RNA" evidence="3">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="3">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037010-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="86" mass="10135" checksum="B8A209EA9F548E8E" modified="2018-02-28" version="1">MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPCGPPADKPEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LW79</accession>
    <name>A0A2I3LW79_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein 423</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Olf1/EBF-associated zinc finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Smad- and Olf-interacting zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ZNF423</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017808831.2">
        <property type="nucleotide sequence ID" value="XM_017953342.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LW79"/>
    <dbReference type="STRING" id="9555.ENSPANP00000027707"/>
    <dbReference type="Ensembl" id="ENSPANT00000040093.2">
        <property type="protein sequence ID" value="ENSPANP00000027707.2"/>
        <property type="gene ID" value="ENSPANG00000022231.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025734"/>
    <dbReference type="CTD" id="23090"/>
    <dbReference type="GeneTree" id="ENSGT00940000158492"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022231">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LW79">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </feature>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055444"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027707.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138068" checksum="8533F71C50DE4EB1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LWL4</accession>
    <name>A0A2I3LWL4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prolactin regulatory element-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mammalian guanine nucleotide exchange factor Sec12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PREB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases. In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908445.1">
        <property type="nucleotide sequence ID" value="XM_003908396.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LWL4"/>
    <dbReference type="Ensembl" id="ENSPANT00000036758.2">
        <property type="protein sequence ID" value="ENSPANP00000027823.2"/>
        <property type="gene ID" value="ENSPANG00000009016.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025786"/>
    <dbReference type="KEGG" id="panu:101025786"/>
    <dbReference type="CTD" id="10113"/>
    <dbReference type="GeneTree" id="ENSGT00390000018031"/>
    <dbReference type="OMA" id="YYVQPRI"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009016">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027823.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="417" mass="45509" checksum="19B141426889B8C1" modified="2022-05-25" version="2">MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLERINGRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQKGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKNQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVISCLNVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIVVTILLLQSAFPGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LXB4</accession>
    <name>A0A2I3LXB4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="23">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ATP2C2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts (via N-terminus) with ORAI1 (via N- and C-termini); this interaction regulates Ca(2+) influx at the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="23"/>
    <dbReference type="RefSeq" id="XP_021787918.1">
        <property type="nucleotide sequence ID" value="XM_021932226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LXB4"/>
    <dbReference type="Ensembl" id="ENSPANT00000043091.2">
        <property type="protein sequence ID" value="ENSPANP00000028100.2"/>
        <property type="gene ID" value="ENSPANG00000021835.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013457"/>
    <dbReference type="CTD" id="9914"/>
    <dbReference type="GeneTree" id="ENSGT00940000160275"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021835">
        <property type="expression patterns" value="Expressed in prostate gland and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LXB4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061180">
        <property type="term" value="P:mammary gland epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090280">
        <property type="term" value="P:positive regulation of calcium ion import"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02085">
        <property type="entry name" value="P-type_ATPase_SPCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000051">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 23" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 23" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="960"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028100.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113047" checksum="0142A35091221DF8" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M6Z9</accession>
    <name>A0A2I3M6Z9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc fingers and homeoboxes protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Zinc finger and homeodomain protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ZHX3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer (via homeobox domain 1). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX2 (via homeobox domain 1). Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZHX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017800301.1">
        <property type="nucleotide sequence ID" value="XM_017944812.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017800302.1">
        <property type="nucleotide sequence ID" value="XM_017944813.2"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0862">Zinc</keyword>
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            <begin position="772"/>
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            <begin position="624"/>
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            <begin position="774"/>
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    <sequence length="956" mass="104564" checksum="EE05435B0134C0F9" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M944</accession>
    <name>A0A2I3M944_PAPAN</name>
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        <submittedName>
            <fullName evidence="6">WD repeat domain 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">WDR53</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000033361.2"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Bgee" id="ENSPANG00000033361">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Apc4-like_WD40_dom"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
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    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="358" mass="38990" checksum="B15C8E5F798DFB2F" modified="2018-02-28" version="1">MAVKWTGGHSSPVLCLNASKEGLLASGAEGGGLTAWGEDGTPLGHMRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDVENKKVVRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTLGVSQVCFLPESYLLLTGGNDGKIMLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGGNTDASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MDL6</accession>
    <name>A0A2I3MDL6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Shiftless antiviral inhibitor of ribosomal frameshifting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SHFL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHFL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003914908.1">
        <property type="nucleotide sequence ID" value="XM_003914859.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MDL6"/>
    <dbReference type="Ensembl" id="ENSPANT00000056811.2">
        <property type="protein sequence ID" value="ENSPANP00000033882.1"/>
        <property type="gene ID" value="ENSPANG00000029871.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101017350"/>
    <dbReference type="KEGG" id="panu:101017350"/>
    <dbReference type="CTD" id="55337"/>
    <dbReference type="GeneTree" id="ENSGT00390000005065"/>
    <dbReference type="OMA" id="PVPKDKM"/>
    <dbReference type="OrthoDB" id="9423182at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029871">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035456">
        <property type="term" value="P:response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034340">
        <property type="term" value="P:response to type I interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034342">
        <property type="term" value="P:response to type III interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026795">
        <property type="entry name" value="SHFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135">
        <property type="entry name" value="REPRESSOR OF YIELD OF DENV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135:SF2">
        <property type="entry name" value="SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15135">
        <property type="entry name" value="UPF0515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="292" mass="33238" checksum="660510094B358FCA" modified="2018-02-28" version="1">MSQEGVELEKSVRRLREKFHGKVSSKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDRDIQAVATSLLPLTQANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPADKMWGLAEFHCPKCRHNFRGWAQMGSPSPCYGCGFPVYPTRILPPRWDRDPDRRSTHTHSCSAADCYNRREPHVPGTSCAHPKSRKQNHLPKVLHPSNPHISSGSTVATCLSQGGLLEDLDNLILEDLKEEEEEEEEEVEDEEGGPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MKG4</accession>
    <name>A0A2I3MKG4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ANXA13</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003903185.1">
        <property type="nucleotide sequence ID" value="XM_003903136.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MKG4"/>
    <dbReference type="Ensembl" id="ENSPANT00000041921.2">
        <property type="protein sequence ID" value="ENSPANP00000036263.1"/>
        <property type="gene ID" value="ENSPANG00000008190.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015845"/>
    <dbReference type="CTD" id="312"/>
    <dbReference type="GeneTree" id="ENSGT00940000159797"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008190">
        <property type="expression patterns" value="Expressed in ileum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000011">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009166">
        <property type="entry name" value="ANX13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF175">
        <property type="entry name" value="ANNEXIN A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01811">
        <property type="entry name" value="ANNEXINXIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0041">Annexin</keyword>
    <keyword evidence="9 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 16" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="316" mass="35407" checksum="C76AB801B9CFED91" modified="2018-02-28" version="1">MGNHHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKTTYGKELEEVLESELSGNFKKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEDYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEGYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQGIKAKFQEKYQKSLSDMVHSDTSGDFRKLLVALLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MKX5</accession>
    <name>A0A2I3MKX5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Odontogenesis associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MKX5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000036418"/>
    <dbReference type="Ensembl" id="ENSPANT00000032522.2">
        <property type="protein sequence ID" value="ENSPANP00000036418.2"/>
        <property type="gene ID" value="ENSPANG00000048399.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00560000078715"/>
    <dbReference type="OMA" id="PESIFGF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018916">
        <property type="expression patterns" value="Expressed in pituitary gland and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MKX5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035259089" description="Odontogenesis associated phosphoprotein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036418.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20129" checksum="E5BED579A73FA411" modified="2022-05-25" version="2">MARRHCFSYWLLVCWLAVTVAEAPSTFYLQQHSNLHMDKKRYLPLLETHKITQTLPTARSLHSPLHPPRGVRSQGSSPSQRHLGVPSIFFHEGPESILGFQTDLSCLQGVTTVFRSSHFIGHTVALLLIDISPEEDSRGEAHLRKAEREEKPKHTEAKKSQSFKKQQKDFCFIFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MMQ5</accession>
    <name>A0A2I3MMQ5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger protein 696</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MMQ5"/>
    <dbReference type="Ensembl" id="ENSPANT00000010806.3">
        <property type="protein sequence ID" value="ENSPANP00000037002.2"/>
        <property type="gene ID" value="ENSPANG00000039338.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000240157"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015054">
        <property type="expression patterns" value="Expressed in thymus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MMQ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037002.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5183" checksum="D3144A603C7B4831" modified="2022-05-25" version="2">VEPGGEPPGAKESSTLMEALAETGSHCVGQTGLKFQVSSGPPASASQSAGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MVA1</accession>
    <name>A0A2I3MVA1_PAPAN</name>
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        <submittedName>
            <fullName evidence="10">Kielin cysteine rich BMP regulator</fullName>
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        <name evidence="10" type="primary">KCP</name>
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    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSPANT00000032536.2">
        <property type="protein sequence ID" value="ENSPANP00000039531.2"/>
        <property type="gene ID" value="ENSPANG00000021951.3"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3MVA1">
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd19941">
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        <property type="match status" value="1"/>
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        <property type="match status" value="11"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
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        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
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    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
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    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
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        <property type="entry name" value="VWF_dom"/>
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    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
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    <dbReference type="PANTHER" id="PTHR46698:SF2">
        <property type="entry name" value="KIELIN_CHORDIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VWC"/>
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    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FnI-like domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VWFC_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5035228274" evidence="7">
        <location>
            <begin position="22"/>
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    <feature type="domain" description="VWFC" evidence="8">
        <location>
            <begin position="106"/>
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    <feature type="domain" description="VWFC" evidence="8">
        <location>
            <begin position="220"/>
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    <feature type="domain" description="VWFC" evidence="8">
        <location>
            <begin position="279"/>
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    <feature type="domain" description="VWFC" evidence="8">
        <location>
            <begin position="396"/>
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    <feature type="domain" description="VWFC" evidence="8">
        <location>
            <begin position="458"/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
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                <person name="Javaid M.J."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
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                <person name="Okwuonu G.O."/>
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                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
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                <person name="Aqrawi P.A."/>
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                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Bell A.B."/>
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                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A8I5MXQ6"/>
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        <property type="entry name" value="7tmA_OR8K-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
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    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="OLFACTORYR"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
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    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="310" mass="35487" checksum="B1A3196511670C0C" modified="2022-05-25" version="1">MAQINCTQVTEFILVGLTDHQELKMPLFVLFLSIYLFTVVGNLGLILLIKTDTRLNTPMYFFLSNLAFVDFCYSSVITPKMFGNFLYKQNVLSFNACATQLGCFLTFMISECLLLASMAYDRYVAICNPLLYMIVMSPGICIQFVAVPYSYSFLMALFHTILTFRLSYCHSNIVNHFYCDDLPLLRLTRSDTRFKQLWIFACAGITFISSLLIVFVSYMFIISAILRMRSAEGRQKSFSTCGSHMLADTIFYGTLIFMYLQPNSNHALDTDKMASVFYTVVIPMLNPLIYSLRNKEVKEALKKVIIDKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MYA8</accession>
    <name>A0A8I5MYA8_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Oxidative stress induced growth inhibitor family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OSGIN2</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000087">
        <property type="entry name" value="oxidative stress-induced growth inhibitor 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF4">
        <property type="entry name" value="OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="850" mass="92537" checksum="B6435DE063CBCABD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N054</accession>
    <name>A0A8I5N054_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N054"/>
    <dbReference type="Ensembl" id="ENSPANT00000063432.1">
        <property type="protein sequence ID" value="ENSPANP00000048572.1"/>
        <property type="gene ID" value="ENSPANG00000044377.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="89" mass="9864" checksum="A808B1621FAE09FA" modified="2022-05-25" version="1">FLNGVSLCCPGWSAVVRPWLTVTSLPCGFKRFSCLSLPSSWDYKHVPPRPANFCIFSKYGVSPCWPGWSRSPDLVICPPRPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N055</accession>
    <name>A0A8I5N055_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N055"/>
    <dbReference type="Ensembl" id="ENSPANT00000070065.1">
        <property type="protein sequence ID" value="ENSPANP00000051099.1"/>
        <property type="gene ID" value="ENSPANG00000039655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003248"/>
    <dbReference type="OMA" id="MAYPMKP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000011">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="10">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="109" mass="12207" checksum="DE54BA00735EE400" modified="2022-05-25" version="1">MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKTLRITTRKTPCGEGSKTWDRFQMRIHKPLTDLHSPSEIVKQITSISIEPGVEVEVTIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0I6</accession>
    <name>A0A8I5N0I6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0I6"/>
    <dbReference type="Ensembl" id="ENSPANT00000066193.1">
        <property type="protein sequence ID" value="ENSPANP00000052542.1"/>
        <property type="gene ID" value="ENSPANG00000039942.1"/>
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    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="F138DOMAIN"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052542.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="104" mass="11003" checksum="4180D31F080ABF31" modified="2022-05-25" version="1">GISAVSAGQFQRYPPTISPSDRNRNWIASEQKNNVSISASRVAGITSVCHHARLSLVFLVKTRFHHVGQAGLELLTSSDPPASACGSAGITGMSHRAQPHLTSL</sequence>
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    <accession>A0A8I5N205</accession>
    <name>A0A8I5N205_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
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        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF133">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F138DOMAIN"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="177" mass="18858" checksum="02961AC66AE3F305" modified="2022-05-25" version="1">MGQVWDSPAVCLSFSQSVDLSLSPGYPLLSLPPISIPPTSTDIWPPTTTLAPESTQSSSTEPTFFFFFFLIESHSVPRLECSGTVSAHCNLHLPGSSNSPASVSRVAGTIGTCLHASPIFVFLGKMGFHRIGQAGLELLTSSDPPASASQSAGITGVYHHAWLFFFFGRNRDLTNVA</sequence>
</entry>
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    <accession>A0A8I5N2Q3</accession>
    <name>A0A8I5N2Q3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="common">Olive baboon</name>
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        <lineage>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A8I5N2Q3"/>
    <dbReference type="Ensembl" id="ENSPANT00000077884.1">
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            <begin position="93"/>
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            <begin position="135"/>
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            <begin position="360"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="375" mass="39151" checksum="719820137E83807D" modified="2022-05-25" version="1">MPFSIQGRGHSSADPIFLPSSWEAIPGDLEVMGKAPHCPWYPRAAVSPSRSPGICGATPGTGPPGRLSAAPPHGPPPTCAGCSEPPSPRRSRSAGPRSGRCNPCRRRRAGHTRGGGARRAPGRSHTSSGWCETLAPPPRSAPPTEPRPAPTNPRGFWPKLKMKPGKGAWGSPRSRVWAGPAASGRISDPETRGDPGRPWGMGRGRDLRPGPGPLTSLALVVVAEQDPQVHSVSLCVGLGDPCVPVPILRLLLLHPRRPRLHPRTRGVAVEPHELRVVHVAHGDEAGLPAAGPGRAGAEIPHGVRGWGRGEAETRPTLLPARLPGSCAPACGPLAPPRRGHFPPDPALTGPGLGQGQGPREQQKEGSGRHDPHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N385</accession>
    <name>A0A8I5N385_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
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                <person name="Han Y.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Attaway T.A."/>
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                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
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                <person name="Fernandez S.F."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
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                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
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                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Pham C.P."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Sisson I.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7D6"/>
    <dbReference type="SMR" id="A0A8I5N7D6"/>
    <dbReference type="Ensembl" id="ENSPANT00000065349.1">
        <property type="protein sequence ID" value="ENSPANP00000056875.1"/>
        <property type="gene ID" value="ENSPANG00000046712.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000819"/>
    <dbReference type="OMA" id="SEDIHCK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064:SF1">
        <property type="entry name" value="PROTON-TRANSPORTING V-TYPE ATPASE COMPLEX ASSEMBLY REGULATOR TMEM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035200377" evidence="7">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="20574" checksum="6BC020EC9FE7F70E" modified="2022-05-25" version="1">MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7Z9</accession>
    <name>A0A8I5N7Z9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7Z9"/>
    <dbReference type="Ensembl" id="ENSPANT00000073750.1">
        <property type="protein sequence ID" value="ENSPANP00000048034.1"/>
        <property type="gene ID" value="ENSPANG00000043930.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000077491.1">
        <property type="protein sequence ID" value="ENSPANP00000047769.1"/>
        <property type="gene ID" value="ENSPANG00000042560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000140957"/>
    <dbReference type="OMA" id="CAVDARC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051896">
        <property type="entry name" value="TCR_alpha_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19339:SF2">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19339">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="117" mass="12726" checksum="90CDCEC04556796B" modified="2022-05-25" version="1">GIQVEQSPPDLILQEGANSTLRCNFSATVNNLQWFHQNPWGQLINLFYIPSGTKQNGRLSATTVTKERYSLLHISSSQTTDSGIYFCAVESQCSPGTCSLYTNPQLGSVPLPATTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCE9</accession>
    <name>A0A8I5NCE9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adenosine deaminase domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Testis nuclear RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADAD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for male fertility and normal male germ cell differentiation. Plays a role in spermatogenesis. Binds to RNA but not to DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ADAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031520164.1">
        <property type="nucleotide sequence ID" value="XM_031664304.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520165.1">
        <property type="nucleotide sequence ID" value="XM_031664305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCE9"/>
    <dbReference type="Ensembl" id="ENSPANT00000072925.1">
        <property type="protein sequence ID" value="ENSPANP00000059269.1"/>
        <property type="gene ID" value="ENSPANG00000005749.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004318"/>
    <dbReference type="KEGG" id="panu:101004318"/>
    <dbReference type="CTD" id="132612"/>
    <dbReference type="GeneTree" id="ENSGT00940000156842"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19905">
        <property type="entry name" value="DSRM_ADAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000033">
        <property type="entry name" value="Adenosine deaminase domain-containing 1 (testis-specific)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044455">
        <property type="entry name" value="ADAD1_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF103">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="13">
        <location>
            <begin position="249"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="576" mass="64240" checksum="40C75F028586F8C1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCT9</accession>
    <name>A0A8I5NCT9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCT9"/>
    <dbReference type="Ensembl" id="ENSPANT00000061638.1">
        <property type="protein sequence ID" value="ENSPANP00000059521.1"/>
        <property type="gene ID" value="ENSPANG00000040057.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="102" mass="11181" checksum="0B6FED078CC15E6D" modified="2022-05-25" version="1">RSSPFARASSSLHQEKKTKSLETLFFFFFLRRSLALSPRLECSGQISAHCKLRLPGSRHSPASASRVAGTTGAATSPGYFLYFLVETGFHRVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGG8</accession>
    <name>A0A8I5NGG8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PTB-containing, cubilin and LRP1-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosine interaction domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PID1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Increases proliferation of preadipocytes without affecting adipocytic differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and CUBN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGG8"/>
    <dbReference type="Ensembl" id="ENSPANT00000073267.1">
        <property type="protein sequence ID" value="ENSPANP00000053758.1"/>
        <property type="gene ID" value="ENSPANG00000042685.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048154"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071354">
        <property type="term" value="P:cellular response to interleukin-6"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044320">
        <property type="term" value="P:cellular response to leptin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001170">
        <property type="term" value="P:negative regulation of ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903077">
        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001171">
        <property type="term" value="P:positive regulation of ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070346">
        <property type="term" value="P:positive regulation of fat cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000379">
        <property type="term" value="P:positive regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13167">
        <property type="entry name" value="PTB_P-CLI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000156">
        <property type="entry name" value="PTB-containing, cubilin and LRP1-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039112">
        <property type="entry name" value="PID1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039114">
        <property type="entry name" value="PID1_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16265">
        <property type="entry name" value="PTB-CONTAINING, CUBILIN AND LRP1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16265:SF1">
        <property type="entry name" value="PTB-CONTAINING, CUBILIN AND LRP1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="9">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="281" mass="31543" checksum="007DD500315E88B3" modified="2022-05-25" version="1">MCLLSHDSLSKAEDPCAHPAAVASARTHIPRTPTPDVKRDNSPSPPGAIDSPASVSSTKPQDWKMWQPATERLQHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELCTTTPLMKTRTHSGCKVTYLGKVSTTGMQFLSGCTEKPVIELWKKHTLAREDVFPANALLEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSYQMDCHAVECESKLEAKKLAHAMMEAFRKTFHSMKSDGRIHSNSSSEEVSQELESDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHD6</accession>
    <name>A0A8I5NHD6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031512489.1">
        <property type="nucleotide sequence ID" value="XM_031656629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHD6"/>
    <dbReference type="Ensembl" id="ENSPANT00000069861.1">
        <property type="protein sequence ID" value="ENSPANP00000058661.1"/>
        <property type="gene ID" value="ENSPANG00000042302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101014317"/>
    <dbReference type="GeneTree" id="ENSGT00960000186656"/>
    <dbReference type="OMA" id="YICRRWN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001726">
        <property type="entry name" value="Signal-regulatory protein beta 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051755">
        <property type="entry name" value="Ig-like_CS_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19971">
        <property type="entry name" value="SIGNAL-REGULATORY PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="277"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="418" mass="47517" checksum="E99FBB5B58BC410F" modified="2022-05-25" version="1">MNLSQVLRVVPTLKITTETSGTRVRVQDRVNLTCHVLHFYPAHLRLTWMENRRMIQTLASPQATRNRDGTYSLEHTWQAEVTPEEREFACWVVHDEQPPLKANVTLQGQVHKQGKGRSVQPYKLQGPLQRSEPGTRIRLTYTSSGFATPQVTVTWLKNKHELPNPQTSVQYSGHTYNVTSSVLVLLTDDDVFSHVICHVEHKLTLFFQKTIGLDQYLREPMAVVWRHLTLPSSPRAPPQLPRFQHPESSILRPCSFLREIPVLSWCAERERLSSVPPTVTVFQSSTSSSLVAVTCLVQRFYPQNVHLTWLEDCHTLKGAEQPTFKKNDDGSYTLENLLLVNASVQGPERVLTCMVEHEGQPPKRANLILSTRAHTAYKPIGSTGPEMPALIFVVFLLGLKVLLVMSFTATYICRRWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJ28</accession>
    <name>A0A8I5NJ28_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Neurexin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Neurexin I-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Neurexin-1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">NRXN1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="22">Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Also interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN2, NLGN3 and NLGN4L; interactions with NLGN1, NLGN2, NLGN3 and NLGN4L are calcium-dependent. Interacts (via cytoplasmic C-terminal region) with CASK (via the PDZ, SH3 and guanylate kinase-like domains). Interacts (via cytoplasmic C-terminus) with CASKIN1 and APBA1. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3. Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4. Interacts with SYT13 and SYTL1. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4. Interacts with CLSTN3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Presynaptic cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031511421.1">
        <property type="nucleotide sequence ID" value="XM_031655561.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000064163.1">
        <property type="protein sequence ID" value="ENSPANP00000047977.1"/>
        <property type="gene ID" value="ENSPANG00000035821.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101013517"/>
    <dbReference type="CTD" id="9378"/>
    <dbReference type="GeneTree" id="ENSGT00940000154292"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042297">
        <property type="term" value="P:vocal learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071625">
        <property type="term" value="P:vocalization behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000029">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000167">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000001">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000003">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000004">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000005">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000007">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000014">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF51">
        <property type="entry name" value="NEUREXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LAM_G_DOMAIN"/>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="3 23" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="13 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035166459" description="Neurexin-1" evidence="26">
        <location>
            <begin position="26"/>
            <end position="1477"/>
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        <location>
            <begin position="1403"/>
            <end position="1423"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="27">
        <location>
            <begin position="30"/>
            <end position="217"/>
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    </feature>
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        <location>
            <begin position="219"/>
            <end position="256"/>
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        <location>
            <begin position="283"/>
            <end position="473"/>
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    <feature type="domain" description="Laminin G" evidence="27">
        <location>
            <begin position="480"/>
            <end position="672"/>
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    <feature type="domain" description="EGF-like" evidence="28">
        <location>
            <begin position="676"/>
            <end position="713"/>
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    <feature type="domain" description="Laminin G" evidence="27">
        <location>
            <begin position="718"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="27">
        <location>
            <begin position="905"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="28">
        <location>
            <begin position="1083"/>
            <end position="1120"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="27">
        <location>
            <begin position="1126"/>
            <end position="1294"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="198"/>
            <end position="221"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1325"/>
            <end position="1390"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1444"/>
            <end position="1477"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035005"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044151"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1477" mass="161941" checksum="38ED319042C0FBE1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKQ9</accession>
    <name>A0A8I5NKQ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 76 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CEP76</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with CCP110 and CEP97.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP76 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009190597.2">
        <property type="nucleotide sequence ID" value="XM_009192333.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKQ9"/>
    <dbReference type="Ensembl" id="ENSPANT00000078202.1">
        <property type="protein sequence ID" value="ENSPANP00000056338.1"/>
        <property type="gene ID" value="ENSPANG00000022968.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010569"/>
    <dbReference type="KEGG" id="panu:101010569"/>
    <dbReference type="CTD" id="79959"/>
    <dbReference type="GeneTree" id="ENSGT00390000000781"/>
    <dbReference type="OMA" id="RRWWSEY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000003">
        <property type="entry name" value="Centrosomal protein of 76 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056289">
        <property type="entry name" value="CEP76_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24654">
        <property type="entry name" value="CEP76_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76 N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76 C2" evidence="8">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="11">
        <location>
            <begin position="361"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="9">
        <location>
            <begin position="518"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="659" mass="74433" checksum="3AD89C525A72FEDA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NPW6</accession>
    <name>A0A8I5NPW6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA annealing helicase and endonuclease ZRANB3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Annealing helicase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Zinc finger Ran-binding domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ZRANB3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031507613.1">
        <property type="nucleotide sequence ID" value="XM_031651753.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507614.1">
        <property type="nucleotide sequence ID" value="XM_031651754.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507615.1">
        <property type="nucleotide sequence ID" value="XM_031651755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NPW6"/>
    <dbReference type="Ensembl" id="ENSPANT00000065393.1">
        <property type="protein sequence ID" value="ENSPANP00000051136.1"/>
        <property type="gene ID" value="ENSPANG00000007838.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024383"/>
    <dbReference type="CTD" id="84083"/>
    <dbReference type="GeneTree" id="ENSGT00940000158559"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000024">
        <property type="entry name" value="DNA annealing helicase and endonuclease ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000788">
        <property type="entry name" value="DNA annealing helicase and endonuclease ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000011">
        <property type="entry name" value="Zinc finger RANBP2-type containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="46"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="25">
        <location>
            <begin position="325"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="538"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00084025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1078" mass="122706" checksum="705E00ECF69491D9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NT91</accession>
    <name>A0A8I5NT91_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OR10A3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NT91"/>
    <dbReference type="Ensembl" id="ENSPANT00000074958.1">
        <property type="protein sequence ID" value="ENSPANP00000053094.1"/>
        <property type="gene ID" value="ENSPANG00000039457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286970"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="314" mass="35279" checksum="337DED4924567453" modified="2022-05-25" version="1">MKRQNQSCVVEFILLGFSNFPELQERLFGIFLVIYVVTLMGNAIVIVVISLNQRLHVPMDLFLLNLSVVEVSFSAIITPEMLVVLSTEKTTVSFVDCFAQMYFILLFGGTECFLLGAMAYDRFAAICHPLNYQVIMNRGVFMKLVMFSWISGIMVATVQTTWVFSFLFCGPNEINHLSCETAAVLELVCADTFLSEIFAFTGTILIVMVPFLLILLSYTRVLFAILKMPSTTGRQKAFSTCASHLTSVTLFYGTANMTYLQPKSGYSPETKKLMSLSYSLLTPLLNPIIYTLQNSDMKRALIKLCQRNVVLHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU39</accession>
    <name>A0A8I5NU39_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU39"/>
    <dbReference type="Ensembl" id="ENSPANT00000068473.1">
        <property type="protein sequence ID" value="ENSPANP00000058756.1"/>
        <property type="gene ID" value="ENSPANG00000037762.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="RLGVQWR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274906" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10885" checksum="4D3C9DE14C3D015C" modified="2022-05-25" version="1">MLLSKRVFVLIFFFFFFFERESRSVAQAGVQWHDHGSLQPLSPRFKVFFCLSLSSSWDYRHTPPCLANFCIFSRDRVSPYWPGWSRTPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU55</accession>
    <name>A0A8I5NU55_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU55"/>
    <dbReference type="Ensembl" id="ENSPANT00000079095.1">
        <property type="protein sequence ID" value="ENSPANP00000061132.1"/>
        <property type="gene ID" value="ENSPANG00000048489.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="206" mass="22932" checksum="DB92DD3B3567FBB1" modified="2022-05-25" version="1">MIIARYSLKVLGSSNPSRQPPRVAGTTSMHHHAWLIFILFYFILSYLFIYLLRRSFILVTQARVQQHDLSSLQSPPPSFKQFSCLSLLSSWITGMRHHVWLIFVFLIAIAFCHVGQAGLKLLTSGDPPASASQSSGITGVGHHARPNSALCKLPKLLSFSFQACKLILPPPLLCEEEMTQCMLGYSCILNSRGSIITVPPPREVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NV25</accession>
    <name>A0A8I5NV25_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leptin receptor gene-related protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endospanin-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">OB-R gene-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LEPROT</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with LEPR. Interacts with RAB13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031525435.1">
        <property type="nucleotide sequence ID" value="XM_031669575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NV25"/>
    <dbReference type="Ensembl" id="ENSPANT00000079549.1">
        <property type="protein sequence ID" value="ENSPANP00000056738.1"/>
        <property type="gene ID" value="ENSPANG00000003123.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005653"/>
    <dbReference type="KEGG" id="panu:101005653"/>
    <dbReference type="CTD" id="54741"/>
    <dbReference type="GeneTree" id="ENSGT00390000006503"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060400">
        <property type="term" value="P:negative regulation of growth hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF3">
        <property type="entry name" value="LEPTIN RECEPTOR GENE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="131" mass="14254" checksum="0F9CE741C2C5ED9C" modified="2022-05-25" version="1">MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGDDFSWEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NWB1</accession>
    <name>A0A8I5NWB1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-glutamylaminecyclotransferase</fullName>
            <ecNumber evidence="6">4.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GGACT</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:16961"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:133752"/>
            <dbReference type="EC" id="4.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.8" evidence="6"/>
    <dbReference type="RefSeq" id="XP_003914089.1">
        <property type="nucleotide sequence ID" value="XM_003914040.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009190436.1">
        <property type="nucleotide sequence ID" value="XM_009192172.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511504.1">
        <property type="nucleotide sequence ID" value="XM_031655644.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511506.1">
        <property type="nucleotide sequence ID" value="XM_031655646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NWB1"/>
    <dbReference type="Ensembl" id="ENSPANT00000075372.1">
        <property type="protein sequence ID" value="ENSPANP00000054750.1"/>
        <property type="gene ID" value="ENSPANG00000044025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025128"/>
    <dbReference type="KEGG" id="panu:101025128"/>
    <dbReference type="CTD" id="87769"/>
    <dbReference type="GeneTree" id="ENSGT00390000010543"/>
    <dbReference type="OMA" id="FENIPTM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042219">
        <property type="term" value="P:modified amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000008">
        <property type="entry name" value="Gamma-glutamylaminecyclotransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="153" mass="17375" checksum="E70023A2DB443857" modified="2022-05-25" version="1">MALVFLYGTLKRGQPNHRVLWDGAHGSAAFRARGRTLDPYPLVIAGEHNIPWLLHLPGSGRRVEGEVYTVDERMLRFLDDFESCPALYQRTALRVQLLEEGAPGAEEPPAPTTVQCFVYSRATFPPEWAQLPHYDSYDSEGPHGLRYNPRENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NWK8</accession>
    <name>A0A8I5NWK8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NWK8"/>
    <dbReference type="Ensembl" id="ENSPANT00000065120.1">
        <property type="protein sequence ID" value="ENSPANP00000058935.1"/>
        <property type="gene ID" value="ENSPANG00000037057.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="FEMESHC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="95" mass="10978" checksum="264FBE99B36FA55D" modified="2022-05-25" version="1">MPCFIYFFEMESHCVTQARVQWCNLGSLQPLPPGFKRFSCLSLPSSWDYRCAPPHPANFCIFSRDWVSLCWSSWSQTPDEVIRPPQPPKVLGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXV7</accession>
    <name>A0A8I5NXV7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NXV7"/>
    <dbReference type="Ensembl" id="ENSPANT00000063450.1">
        <property type="protein sequence ID" value="ENSPANP00000059458.1"/>
        <property type="gene ID" value="ENSPANG00000044686.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00860000136085"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="275" mass="29623" checksum="5E7595D64D9AEB30" modified="2022-05-25" version="1">MLTKVLLPLRWERLPRPSRPADRESLAAPGFSRRQLEGARARGLREGLGSGEVRGASGGPRVGGGMEGPREGGPREGRGWEVDGGGGPREGWSPLKAGDDPDPAYFSWGSFAGPRKLRVCFFVPISLLTLFLLLCFPPPAALTALQFAWEGNRDFLFALSAGTSVLALRGLEDAALWGKPGWQEVAGLLEEVLGWLLWLLKKIPRTQPAPSPSFQGAPRGERDLCGVDKVTLNSFPPEKGESKLLPGHLSSCGVSPSDMRRCLSGAAWPGHSYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R064</accession>
    <name>A0A8I5R064_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">H3 clustered histone 13</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Davy-Carroll L.D."/>
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                <person name="Dinh H.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
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                <person name="Kalu J.K."/>
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                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
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                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Han Y.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="2">Chromosome</location>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <text evidence="3">Belongs to the histone H3 family.</text>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0164">Citrullination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="154" mass="17239" checksum="87C704B9037E5F8F" modified="2022-05-25" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6Y4</accession>
    <name>A0A8I5R6Y4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interaction protein for cytohesin exchange factors 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IPCEF1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6Y4"/>
    <dbReference type="Ensembl" id="ENSPANT00000082341.1">
        <property type="protein sequence ID" value="ENSPANP00000052808.1"/>
        <property type="gene ID" value="ENSPANG00000023119.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154428"/>
    <dbReference type="OMA" id="ENSFAMS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01260">
        <property type="entry name" value="PH_CNK_mammalian-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000092">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF45">
        <property type="entry name" value="CNK3_IPCEF1 FUSION PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035309673" evidence="2">
        <location>
            <begin position="16"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="455" mass="51433" checksum="9010AE53F08AA39C" modified="2022-05-25" version="1">MTHFFLSLFFFFCKGQRQQNWTKKVHNFLQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGLAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSSAAQQASSSSPSLSGTSCSFSSLENTMKTPSSFPSSLSKERQSLPDTVNSSSAAEDEGQPITFAVQVHSPAPSEAGSHKAPENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEEIKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPSPDDTDDTPQELKKSPSSPCVENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6Y5</accession>
    <name>A0A8I5R6Y5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA transcription, translation and transport factor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RTRAF</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTRAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901842.1">
        <property type="nucleotide sequence ID" value="XM_003901793.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6Y5"/>
    <dbReference type="SMR" id="A0A8I5R6Y5"/>
    <dbReference type="Ensembl" id="ENSPANT00000064429.1">
        <property type="protein sequence ID" value="ENSPANP00000052820.1"/>
        <property type="gene ID" value="ENSPANG00000046678.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101012497"/>
    <dbReference type="KEGG" id="panu:101012497"/>
    <dbReference type="CTD" id="51637"/>
    <dbReference type="GeneTree" id="ENSGT00390000005163"/>
    <dbReference type="OMA" id="YPMRILR"/>
    <dbReference type="OrthoDB" id="514167at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="244" mass="28068" checksum="EB2C3C5577A09A2A" modified="2022-05-25" version="1">MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAIDWLLGLAVRLEYGDNAEKYKDLVPDNSKTADNATKNAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R910</accession>
    <name>A0A8I5R910_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R910"/>
    <dbReference type="Ensembl" id="ENSPANT00000069220.1">
        <property type="protein sequence ID" value="ENSPANP00000057680.1"/>
        <property type="gene ID" value="ENSPANG00000049680.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153048"/>
    <dbReference type="OMA" id="KCKASEG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000212">
        <property type="entry name" value="Immunoglobulin kappa chain variable 12-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="112" mass="11932" checksum="BD8FD4599D1FBE82" modified="2022-05-25" version="1">MFLISGARCDIQMSQSPSSLSASVGDRVTITCRASQGISNALAWFQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGYSTPPTVLHTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R942</accession>
    <name>A0A8I5R942_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GRPEL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898489.1">
        <property type="nucleotide sequence ID" value="XM_003898440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R942"/>
    <dbReference type="Ensembl" id="ENSPANT00000073652.1">
        <property type="protein sequence ID" value="ENSPANP00000058016.1"/>
        <property type="gene ID" value="ENSPANG00000042460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101016546"/>
    <dbReference type="KEGG" id="panu:101016546"/>
    <dbReference type="CTD" id="80273"/>
    <dbReference type="GeneTree" id="ENSGT00390000005589"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF25">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="217" mass="24265" checksum="6A63DFB3F82F2EAF" modified="2022-05-25" version="1">MAAQCVRLARRSLPALALSLRPSPRLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKSLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKJ9</accession>
    <name>A0A096MKJ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADAMTS like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ADAMTSL4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021779090.1">
        <property type="nucleotide sequence ID" value="XM_021923398.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779097.1">
        <property type="nucleotide sequence ID" value="XM_021923405.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508431.1">
        <property type="nucleotide sequence ID" value="XM_031652571.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508432.1">
        <property type="nucleotide sequence ID" value="XM_031652572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKJ9"/>
    <dbReference type="Ensembl" id="ENSPANT00000006424.3">
        <property type="protein sequence ID" value="ENSPANP00000000014.2"/>
        <property type="gene ID" value="ENSPANG00000011009.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101019790"/>
    <dbReference type="KEGG" id="panu:101019790"/>
    <dbReference type="CTD" id="54507"/>
    <dbReference type="GeneTree" id="ENSGT00940000161136"/>
    <dbReference type="HOGENOM" id="CLU_000660_6_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011009">
        <property type="expression patterns" value="Expressed in aorta and 36 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MKJ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000085">
        <property type="entry name" value="ADAMTS like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000111">
        <property type="entry name" value="ADAMTS-like protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000023">
        <property type="entry name" value="Thrombospondin type-1 domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000039">
        <property type="entry name" value="thrombospondin type-1 domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF144">
        <property type="entry name" value="ADAMTS-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014185647" evidence="7">
        <location>
            <begin position="27"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000014.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116971" checksum="89129387372211A0" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLM2</accession>
    <name>A0A096MLM2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleckstrin homology like domain family A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PHLDA3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003893356.1">
        <property type="nucleotide sequence ID" value="XM_003893307.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MLM2"/>
    <dbReference type="SMR" id="A0A096MLM2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000451"/>
    <dbReference type="Ensembl" id="ENSPANT00000016675.3">
        <property type="protein sequence ID" value="ENSPANP00000000451.1"/>
        <property type="gene ID" value="ENSPANG00000015274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016731"/>
    <dbReference type="KEGG" id="panu:101016731"/>
    <dbReference type="CTD" id="23612"/>
    <dbReference type="eggNOG" id="ENOG502S2UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039564"/>
    <dbReference type="HOGENOM" id="CLU_062639_1_0_1"/>
    <dbReference type="OMA" id="PSWNADI"/>
    <dbReference type="OrthoDB" id="9630709at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015274">
        <property type="expression patterns" value="Expressed in aorta and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000270">
        <property type="entry name" value="Pleckstrin homology-like domain family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="127" mass="13891" checksum="35014547F840D115" modified="2014-11-26" version="1">MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNE0</accession>
    <name>A0A096MNE0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="5">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CHAC2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031511011.1">
        <property type="nucleotide sequence ID" value="XM_031655151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNE0"/>
    <dbReference type="SMR" id="A0A096MNE0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001166"/>
    <dbReference type="Ensembl" id="ENSPANT00000017645.3">
        <property type="protein sequence ID" value="ENSPANP00000001166.3"/>
        <property type="gene ID" value="ENSPANG00000025448.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017545"/>
    <dbReference type="CTD" id="494143"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003855"/>
    <dbReference type="HOGENOM" id="CLU_070703_0_2_1"/>
    <dbReference type="OMA" id="DHREKDG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025448">
        <property type="expression patterns" value="Expressed in duodenum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000003">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001166.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="184" mass="20875" checksum="E0F10C446A105E22" modified="2022-05-25" version="3">MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPAGCVWGVAYRLPVGKEEEVKAYLDFREKGGYRTTTVIFYPKDPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFNAAGPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKERLEGKQNLNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQC9</accession>
    <name>A0A096MQC9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">MICAL like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MICALL2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003895696.3">
        <property type="nucleotide sequence ID" value="XM_003895647.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQC9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001955"/>
    <dbReference type="Ensembl" id="ENSPANT00000018256.3">
        <property type="protein sequence ID" value="ENSPANP00000001955.3"/>
        <property type="gene ID" value="ENSPANG00000000519.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004982"/>
    <dbReference type="KEGG" id="panu:101004982"/>
    <dbReference type="CTD" id="79778"/>
    <dbReference type="eggNOG" id="ENOG502QVVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160222"/>
    <dbReference type="HOGENOM" id="CLU_015382_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000519">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21253">
        <property type="entry name" value="CH_MICALL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09444">
        <property type="entry name" value="LIM_Mical_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MICAL-like protein 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
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        <property type="entry name" value="bMERB_dom"/>
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        <property type="entry name" value="CH_dom"/>
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        <property type="entry name" value="CH_dom_sf"/>
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        <property type="entry name" value="F-actin_Monoox_Mical"/>
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    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
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        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
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        <property type="entry name" value="MICAL-LIKE PROTEIN 2"/>
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        <property type="entry name" value="bMERB_dom"/>
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        <property type="entry name" value="CH"/>
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        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM"/>
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        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
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    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
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    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="107"/>
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        <location>
            <begin position="186"/>
            <end position="248"/>
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        <location>
            <begin position="729"/>
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        <location>
            <begin position="117"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="261"/>
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    </feature>
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        <location>
            <begin position="739"/>
            <end position="773"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="141"/>
            <end position="153"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="266"/>
            <end position="277"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="342"/>
            <end position="355"/>
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        <location>
            <begin position="364"/>
            <end position="376"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="387"/>
            <end position="402"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="410"/>
            <end position="427"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="483"/>
            <end position="495"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <begin position="522"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <begin position="565"/>
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            <begin position="649"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <begin position="685"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="908" mass="98342" checksum="EA4642563603EF5D" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUS4</accession>
    <name>A0A096MUS4_PAPAN</name>
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        <submittedName>
            <fullName evidence="9">SRY-box transcription factor 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SOX13</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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    <dbReference type="Bgee" id="ENSPANG00000018736">
        <property type="expression patterns" value="Expressed in cornea and 56 other cell types or tissues"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell fate commitment"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003593.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="621" mass="69081" checksum="FF0A9C9B6AE0CC95" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX96</accession>
    <name>A0A096MX96_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA helicase MCM9</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Mini-chromosome maintenance deficient domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Minichromosome maintenance 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MCM9</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9. Interacts with the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1. Interacts with MLH1; the interaction recruits MLH1 to chromatin. Interacts with MSH2; the interaction recruits MCM9 to chromatin. Interacts with MSH6. Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1; the interaction recruits the MRN complex to DNA damage sites. Interacts with RAD51; the interaction recruits RAD51 to DNA damage sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_021793624.2">
        <property type="nucleotide sequence ID" value="XM_021937932.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021793625.2">
        <property type="nucleotide sequence ID" value="XM_021937933.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MX96"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004507"/>
    <dbReference type="Ensembl" id="ENSPANT00000016073.3">
        <property type="protein sequence ID" value="ENSPANP00000004507.3"/>
        <property type="gene ID" value="ENSPANG00000012446.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009408"/>
    <dbReference type="KEGG" id="panu:101009408"/>
    <dbReference type="CTD" id="254394"/>
    <dbReference type="eggNOG" id="KOG0477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286951"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="PFQQGVR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012446">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MX96">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097362">
        <property type="term" value="C:MCM8-MCM9 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032406">
        <property type="term" value="F:MutLbeta complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032407">
        <property type="term" value="F:MutSalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032408">
        <property type="term" value="F:MutSbeta complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070716">
        <property type="term" value="P:mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17760">
        <property type="entry name" value="MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000671">
        <property type="entry name" value="DNA helicase MCM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000120">
        <property type="entry name" value="Probable DNA helicase MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058768">
        <property type="entry name" value="MCM9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26066">
        <property type="entry name" value="MCM9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="21">
        <location>
            <begin position="302"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="656"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="755"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="867"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1064"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1068"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004507.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127502" checksum="DA8EA72208D11AB8" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXS0</accession>
    <name>A0A096MXS0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Solute carrier family 41 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC41A2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) &gt; Ni(2+) &gt; Co(2+) &gt; Fe(2+) &gt; Mn(2+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Co(2+)(in) = Co(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28578"/>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Fe(2+)(in) = Fe(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28486"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Mn(2+)(in) = Mn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28699"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ni(2+)(in) = Ni(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29831"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017801647.2">
        <property type="nucleotide sequence ID" value="XM_017946158.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021778530.1">
        <property type="nucleotide sequence ID" value="XM_021922838.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021778531.1">
        <property type="nucleotide sequence ID" value="XM_021922839.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506571.1">
        <property type="nucleotide sequence ID" value="XM_031650711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MXS0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004698"/>
    <dbReference type="Ensembl" id="ENSPANT00000015308.3">
        <property type="protein sequence ID" value="ENSPANP00000004698.2"/>
        <property type="gene ID" value="ENSPANG00000004472.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020838"/>
    <dbReference type="KEGG" id="panu:101020838"/>
    <dbReference type="CTD" id="84102"/>
    <dbReference type="eggNOG" id="KOG3788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183042"/>
    <dbReference type="HOGENOM" id="CLU_018207_3_0_1"/>
    <dbReference type="OMA" id="NDKAYHG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004472">
        <property type="expression patterns" value="Expressed in liver and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006828">
        <property type="term" value="P:manganese ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015675">
        <property type="term" value="P:nickel cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000002">
        <property type="entry name" value="Solute carrier family 41, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF25">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="18">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="18">
        <location>
            <begin position="414"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046252"/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
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                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
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                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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    <dbReference type="GeneID" id="100999988"/>
    <dbReference type="KEGG" id="panu:100999988"/>
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    <dbReference type="eggNOG" id="ENOG502QRBG">
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    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
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    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043559">
        <property type="term" value="F:insulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="SMP_C2CD2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040885">
        <property type="entry name" value="SMP_C2CD2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF8">
        <property type="entry name" value="PHOSPHOLIPID TRANSFER PROTEIN C2CD2L"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18696">
        <property type="entry name" value="SMP_C2CD2L"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="domain" description="C2" evidence="3">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="575"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0M3</accession>
    <name>A0A096N0M3_PAPAN</name>
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        <alternativeName>
            <fullName evidence="39">G protein-coupled estrogen receptor 1</fullName>
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            <fullName evidence="40">G-protein coupled receptor 30</fullName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="44" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="44" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
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            <location evidence="10">Cell projection</location>
            <location evidence="10">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendritic spine membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network</location>
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        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <subcellularLocation>
            <location evidence="37">Postsynaptic density</location>
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        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
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    </comment>
    <comment type="similarity">
        <text evidence="41">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_003895635.5"/>
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        <property type="nucleotide sequence ID" value="XM_009202469.4"/>
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        <property type="nucleotide sequence ID" value="XM_031665645.1"/>
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        <property type="gene ID" value="ENSPANG00000024982.3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
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    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039464"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00042063"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043164"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005810.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="375" mass="42368" checksum="ED564009D535A40F" modified="2022-05-25" version="3">MDVTSQAWGMGLEMYPGTMQPAAPNTTSPELNLSHLLLGAALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHEQYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKYHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFREKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2C5</accession>
    <name>A0A096N2C5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DENN domain containing 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DENND4B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="STRING" id="9555.ENSPANP00000006468"/>
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        <property type="protein sequence ID" value="ENSPANP00000006468.2"/>
        <property type="gene ID" value="ENSPANG00000003886.4"/>
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    <dbReference type="OMA" id="VVWPGPI"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="Bgee" id="ENSPANG00000003886">
        <property type="expression patterns" value="Expressed in bone marrow and 67 other cell types or tissues"/>
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        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="C-myc promoter-binding protein isoform X1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
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    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
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        <property type="entry name" value="MABP"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4B"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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            <begin position="220"/>
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            <begin position="837"/>
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        <source>
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    </evidence>
    <sequence length="1511" mass="165147" checksum="73F8A4449BAFE003" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N3Q8</accession>
    <name>A0A096N3Q8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        <name evidence="15" type="primary">USP11</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A096N3Q8"/>
    <dbReference type="Ensembl" id="ENSPANT00000025050.3">
        <property type="protein sequence ID" value="ENSPANP00000006993.3"/>
        <property type="gene ID" value="ENSPANG00000012824.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160485"/>
    <dbReference type="HOGENOM" id="CLU_001060_7_1_1"/>
    <dbReference type="OMA" id="TGQLVIM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012824">
        <property type="expression patterns" value="Expressed in mammillary body and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N3Q8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000229">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2230.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000013">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF29">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="14">
        <location>
            <begin position="76"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="309"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006993.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="962" mass="109639" checksum="E8FD97766A266899" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N751</accession>
    <name>A0A096N751_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA damage-induced apoptosis suppressor protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitric oxide-inducible gene protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DDIAS</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May be an anti-apoptotic protein involved in DNA repair or cell survival.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009185278.1">
        <property type="nucleotide sequence ID" value="XM_009187014.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021782053.1">
        <property type="nucleotide sequence ID" value="XM_021926361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N751"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008338"/>
    <dbReference type="Ensembl" id="ENSPANT00000020284.4">
        <property type="protein sequence ID" value="ENSPANP00000008338.1"/>
        <property type="gene ID" value="ENSPANG00000000427.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997645"/>
    <dbReference type="KEGG" id="panu:100997645"/>
    <dbReference type="CTD" id="220042"/>
    <dbReference type="eggNOG" id="ENOG502R2XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014932"/>
    <dbReference type="OMA" id="WQPSLEL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000427">
        <property type="expression patterns" value="Expressed in testis and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N751">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902230">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097752">
        <property type="term" value="P:regulation of DNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000217">
        <property type="entry name" value="DNA damage induced apoptosis suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043522">
        <property type="entry name" value="DDIAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35537:SF1">
        <property type="entry name" value="DNA DAMAGE-INDUCED APOPTOSIS SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35537">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE APOPTOSIS SUPPRESSOR PROTEIN DDIAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0338">Growth arrest</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001921626" description="DNA damage-induced apoptosis suppressor protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112040" checksum="7871C0721D4144D7" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N846</accession>
    <name>A0A096N846_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Matrix metalloproteinase-19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Matrix metalloproteinase RASI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">MMP19</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="25">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="25">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906582.2">
        <property type="nucleotide sequence ID" value="XM_003906533.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N846"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008771"/>
    <dbReference type="MEROPS" id="M10.021"/>
    <dbReference type="Ensembl" id="ENSPANT00000029134.3">
        <property type="protein sequence ID" value="ENSPANP00000008771.2"/>
        <property type="gene ID" value="ENSPANG00000004177.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017529"/>
    <dbReference type="KEGG" id="panu:101017529"/>
    <dbReference type="CTD" id="4327"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158593"/>
    <dbReference type="HOGENOM" id="CLU_015489_8_3_1"/>
    <dbReference type="OMA" id="CRPQTID"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004177">
        <property type="expression patterns" value="Expressed in white adipose tissue and 44 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N846">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000008">
        <property type="entry name" value="Matrix metallopeptidase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000017">
        <property type="entry name" value="Matrix metallopeptidase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000027">
        <property type="entry name" value="Matrix metallopeptidase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF166">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="15 25" id="KW-0106">Calcium</keyword>
    <keyword evidence="17" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="14 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="28">
        <location>
            <begin position="225"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="411"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="459"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="551"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" evidence="24">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="25">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008771.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="633" mass="71386" checksum="6D6F68C516195AB6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8G9</accession>
    <name>A0A096N8G9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Occludin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">OCLN</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with TJP1/ZO1. Interacts with VAPA. Interacts with CLDN1, CLDN6, CLDN9, CLDN11, CLDN12 and CLDN17. Interacts with PLSCR1. Interacts with LSR, ILDR1 and ILDR2. Interacts with TJP2/ZO2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cell junction</location>
            <location evidence="13">Tight junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 16">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899821.1">
        <property type="nucleotide sequence ID" value="XM_003899772.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003899822.1">
        <property type="nucleotide sequence ID" value="XM_003899773.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017815110.1">
        <property type="nucleotide sequence ID" value="XM_017959621.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8G9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008900"/>
    <dbReference type="Ensembl" id="ENSPANT00000011290.4">
        <property type="protein sequence ID" value="ENSPANP00000008900.1"/>
        <property type="gene ID" value="ENSPANG00000025612.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101012708"/>
    <dbReference type="KEGG" id="panu:101012708"/>
    <dbReference type="CTD" id="100506658"/>
    <dbReference type="eggNOG" id="ENOG502QS9F">
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        <location>
            <begin position="67"/>
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        <location>
            <begin position="140"/>
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            <begin position="173"/>
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            <begin position="244"/>
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            <begin position="60"/>
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        <location>
            <begin position="414"/>
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            <begin position="303"/>
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            <begin position="436"/>
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            <begin position="367"/>
            <end position="380"/>
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            <begin position="381"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <begin position="216"/>
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    <sequence length="522" mass="59107" checksum="865EDE7A1FD2BC24" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8H3</accession>
    <name>A0A096N8H3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">WNT5B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N8H3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008904"/>
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        <property type="protein sequence ID" value="ENSPANP00000008904.1"/>
        <property type="gene ID" value="ENSPANG00000010050.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157617"/>
    <dbReference type="HOGENOM" id="CLU_033039_0_1_1"/>
    <dbReference type="OMA" id="IQVERCH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010050">
        <property type="expression patterns" value="Expressed in aorta and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF87">
        <property type="entry name" value="PROTEIN WNT-5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922350" description="Protein Wnt" evidence="12">
        <location>
            <begin position="24"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="359" mass="40405" checksum="349A076C5EB10741" modified="2014-11-26" version="1">MPSLLLLFTAALLSSWVQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTVDNVSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVKCKKCTEIVDQYICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8R9</accession>
    <name>A0A096N8R9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane serine protease 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMPRSS12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003906420.1">
        <property type="nucleotide sequence ID" value="XM_003906371.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8R9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009000"/>
    <dbReference type="MEROPS" id="S01.291"/>
    <dbReference type="Ensembl" id="ENSPANT00000002422.3">
        <property type="protein sequence ID" value="ENSPANP00000009000.1"/>
        <property type="gene ID" value="ENSPANG00000015830.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010270"/>
    <dbReference type="KEGG" id="panu:101010270"/>
    <dbReference type="CTD" id="283471"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161878"/>
    <dbReference type="HOGENOM" id="CLU_006842_0_4_1"/>
    <dbReference type="OMA" id="HEAEVHY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015830">
        <property type="expression patterns" value="Expressed in testis and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902492">
        <property type="term" value="P:positive regulation of sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
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    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF21">
        <property type="entry name" value="TRANSMEMBRANE SERINE PROTEASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001921708" evidence="7">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="348" mass="38591" checksum="59DCF39EC7905F04" modified="2014-11-26" version="1">MRLRLLSVALLFVGSSHLHSDHDSPPGRHSLGPSLERAAGSQQTEAARKRLGRRRQGGAHAKDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYDHTLAHVCGGTLVRERWVLTAAHCTKDASDPLMWRAVIGTNNIHGHHPYTKKIKIKAIIVHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEGNVTNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGIYIGPYFYQKWLTEHFFHASTQGILTLNISHGQILIALCLVILLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NBG2</accession>
    <name>A0A096NBG2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 449</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF449</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918363.2">
        <property type="nucleotide sequence ID" value="XM_003918314.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NBG2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010106"/>
    <dbReference type="Ensembl" id="ENSPANT00000010622.3">
        <property type="protein sequence ID" value="ENSPANP00000010106.2"/>
        <property type="gene ID" value="ENSPANG00000012789.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100998515"/>
    <dbReference type="KEGG" id="panu:100998515"/>
    <dbReference type="CTD" id="203523"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160108"/>
    <dbReference type="HOGENOM" id="CLU_002678_49_8_1"/>
    <dbReference type="OMA" id="LDMNFPL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012789">
        <property type="expression patterns" value="Expressed in adrenal medulla and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NBG2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000467">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000869">
        <property type="entry name" value="Zinc finger protein 213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000959">
        <property type="entry name" value="zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001562">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000070">
        <property type="entry name" value="zinc finger protein 689 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="17">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010106.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="518" mass="59928" checksum="39C03543BFE2BDC7" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NC05</accession>
    <name>A0A096NC05_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leukemia inhibitory factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LIFR</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899646.2">
        <property type="nucleotide sequence ID" value="XM_003899597.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009206574.2">
        <property type="nucleotide sequence ID" value="XM_009208310.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NC05"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010313"/>
    <dbReference type="Ensembl" id="ENSPANT00000013404.3">
        <property type="protein sequence ID" value="ENSPANP00000010313.3"/>
        <property type="gene ID" value="ENSPANG00000017937.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007792"/>
    <dbReference type="KEGG" id="panu:101007792"/>
    <dbReference type="CTD" id="3977"/>
    <dbReference type="eggNOG" id="ENOG502QQF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155776"/>
    <dbReference type="HOGENOM" id="CLU_283805_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017937">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005127">
        <property type="term" value="F:ciliary neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004924">
        <property type="term" value="F:oncostatin-M receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000578">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000607">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000657">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000738">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000808">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001011">
        <property type="entry name" value="leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001124">
        <property type="entry name" value="leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001265">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048497">
        <property type="entry name" value="LIF-R-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040817">
        <property type="entry name" value="LIFR_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040901">
        <property type="entry name" value="LIFR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF105">
        <property type="entry name" value="LEUKEMIA INHIBITORY FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21177">
        <property type="entry name" value="LIF-R_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17971">
        <property type="entry name" value="LIFR_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25552">
        <property type="entry name" value="LIFR_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18207">
        <property type="entry name" value="LIFR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="335"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="435"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="726"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1068"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010313.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123792" checksum="69D8CD9565FF4999" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCI2</accession>
    <name>A0A096NCI2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PIH1D2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003910742.1">
        <property type="nucleotide sequence ID" value="XM_003910693.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009185530.1">
        <property type="nucleotide sequence ID" value="XM_009187266.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NCI2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010529"/>
    <dbReference type="Ensembl" id="ENSPANT00000001958.3">
        <property type="protein sequence ID" value="ENSPANP00000010529.2"/>
        <property type="gene ID" value="ENSPANG00000020254.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008698"/>
    <dbReference type="KEGG" id="panu:101008698"/>
    <dbReference type="CTD" id="120379"/>
    <dbReference type="eggNOG" id="KOG4356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048581"/>
    <dbReference type="HOGENOM" id="CLU_075974_0_0_1"/>
    <dbReference type="OMA" id="SCLCTEI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020254">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NCI2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF6">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="4">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010529.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="315" mass="35958" checksum="CC36C2E019A6843A" modified="2018-02-28" version="2">METSSKGLLTQVTQFWNLLDDLAESDPEGYEKFIQQQLKEGKQLCADPEPQLCLQTRILKPKEKILFINLCQWTRIPAPQSATHPVPLTVGKPEDTTETSDAYTVIDVAYNPDVLQAAEKNQVKKNQLIQMAMKCIEEQFQFTLSHSYHITKFRIKGSIQRMKQNLMGIQTDSIDLREKMRRELTLGQIRSSTMSNPDHFPQLLLRKDQVSGKAVCLIEEISSTEIQVEIKIPAYELKIVHDHNEKPLKTELKVELPGINSVSLCDLSVSEDDLLIEVSEKYRLHLNLPKPIDTEMTTAKFIKENSTLIITMPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEY4</accession>
    <name>A0A096NEY4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="21">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">POLR2B</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="function">
        <text evidence="19">RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:21250"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 3'-end ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a ribonucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77763"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="Rhea" id="RHEA-COMP:18982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:197502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:77764"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="21"/>
    <dbReference type="RefSeq" id="XP_009205290.1">
        <property type="nucleotide sequence ID" value="XM_009207026.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NEY4"/>
    <dbReference type="SMR" id="A0A096NEY4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011472"/>
    <dbReference type="Ensembl" id="ENSPANT00000026440.3">
        <property type="protein sequence ID" value="ENSPANP00000011472.1"/>
        <property type="gene ID" value="ENSPANG00000004759.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005833"/>
    <dbReference type="KEGG" id="panu:101005833"/>
    <dbReference type="CTD" id="5431"/>
    <dbReference type="eggNOG" id="KOG0214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183132"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_2_1"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004759">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NEY4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000026">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 21" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="25">
        <location>
            <begin position="38"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="24">
        <location>
            <begin position="201"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="26">
        <location>
            <begin position="468"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="27">
        <location>
            <begin position="567"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="28">
        <location>
            <begin position="653"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="22">
        <location>
            <begin position="707"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="1082"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1174" mass="133897" checksum="32BEDF7F95E4DE10" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGZ2</accession>
    <name>A0A096NGZ2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Retinal outer segment membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ROM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PRPH2/ROM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909748.1">
        <property type="nucleotide sequence ID" value="XM_003909699.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGZ2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012238"/>
    <dbReference type="Ensembl" id="ENSPANT00000006111.3">
        <property type="protein sequence ID" value="ENSPANP00000012238.1"/>
        <property type="gene ID" value="ENSPANG00000015653.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013280"/>
    <dbReference type="KEGG" id="panu:101013280"/>
    <dbReference type="CTD" id="6094"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159921"/>
    <dbReference type="HOGENOM" id="CLU_068903_0_0_1"/>
    <dbReference type="OMA" id="AARYPPW"/>
    <dbReference type="OrthoDB" id="9836210at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015653">
        <property type="expression patterns" value="Expressed in pineal body and 39 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042622">
        <property type="term" value="C:photoreceptor outer segment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060219">
        <property type="term" value="P:camera-type eye photoreceptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035845">
        <property type="term" value="P:photoreceptor cell outer segment organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051291">
        <property type="term" value="P:protein heterooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903546">
        <property type="term" value="P:protein localization to photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061298">
        <property type="term" value="P:retina vasculature development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03162">
        <property type="entry name" value="peripherin_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000002">
        <property type="entry name" value="Retinal outer segment membrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000830">
        <property type="entry name" value="Peripherin/rom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018498">
        <property type="entry name" value="Peripherin/rom-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042026">
        <property type="entry name" value="Peripherin_LEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00218">
        <property type="entry name" value="PERIPHERNRDS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00930">
        <property type="entry name" value="RDS_ROM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="351" mass="37330" checksum="6BACABDADFFB850B" modified="2014-11-26" version="1">MAPVLPLVLPLQPRIRLAQGLWLLSWLLVLAGGLILLCSGHLLVQLRHLGTFLAPSCQFPALPQAALVAGAVALGTGLVGVGASRASLNAALYPPWRGVLGPMLVAGTAGGGGLLVITLGLALALPGSLDEALEEGLGTALAHYKDTEVPGHCQAKRLVDELQLRYQCCGRHGYKDWFGVQWVSSRYLDPSDQDVVDRIQSNVEGLYLTDGVPFSCCNPHSPRPCLQNRLSDSYAHPLFDPRQPNQNLWAQGCHEVLLEHLQDLAGTLGSMLAVTFLLQALVLLGLRYLQTALEGLGGVIDGEGETQGYLFPGGLKDMLKTAWLQGGVACRPAPEEAPPGEAPPKEDLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NH09</accession>
    <name>A0A096NH09_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apolipoprotein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">APOF</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009179226.2">
        <property type="nucleotide sequence ID" value="XM_009180962.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NH09"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012255"/>
    <dbReference type="Ensembl" id="ENSPANT00000006146.3">
        <property type="protein sequence ID" value="ENSPANP00000012255.2"/>
        <property type="gene ID" value="ENSPANG00000014071.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012295"/>
    <dbReference type="KEGG" id="panu:101012295"/>
    <dbReference type="CTD" id="319"/>
    <dbReference type="eggNOG" id="ENOG502QUQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000045104"/>
    <dbReference type="HOGENOM" id="CLU_078958_0_0_1"/>
    <dbReference type="OMA" id="FTHMAPL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014071">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026114">
        <property type="entry name" value="APOF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15011">
        <property type="entry name" value="APOLIPOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15011:SF3">
        <property type="entry name" value="APOLIPOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15148">
        <property type="entry name" value="Apolipo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315309" evidence="1">
        <location>
            <begin position="37"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012255.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="326" mass="35356" checksum="254A97C6A91402B4" modified="2022-05-25" version="2">MTGLCGYSAPDMCGLRLIMIPVELLLCYVLLHPVDATSYGKQTNVLMHLPLSLESQTPSSDPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQADVWALQLQLYRQGGVNATQVLIQHLRGLQTGRSTERNVSVEALASALQLLAREQQSTGRVWRSLPTEDCENEKEQGVHNVIQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLAISAALKPALRSGVQQLIQYYQDRKDANISQPETTKEGLRAISDVSDLEETTTLASFISEVVSSAPYWGWAIIKSYDLDPGAGSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHY5</accession>
    <name>A0A096NHY5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein axonemal heavy chain 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DNAH8</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031522927.1">
        <property type="nucleotide sequence ID" value="XM_031667067.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522929.1">
        <property type="nucleotide sequence ID" value="XM_031667069.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000012583"/>
    <dbReference type="Ensembl" id="ENSPANT00000020157.3">
        <property type="protein sequence ID" value="ENSPANP00000012583.3"/>
        <property type="gene ID" value="ENSPANG00000016030.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013563"/>
    <dbReference type="KEGG" id="panu:101013563"/>
    <dbReference type="CTD" id="1769"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158992"/>
    <dbReference type="HOGENOM" id="CLU_000038_9_1_1"/>
    <dbReference type="OMA" id="ATEPIMF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016030">
        <property type="expression patterns" value="Expressed in testis and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2059"/>
            <end position="2203"/>
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    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2340"/>
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    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2666"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="3292"/>
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    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3519"/>
            <end position="3560"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="8"/>
            <end position="27"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012583.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="4708" mass="539052" checksum="70153712CBCE5B28" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NKM0</accession>
    <name>A0A096NKM0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome assembly chaperone 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PSMG4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003897027.1">
        <property type="nucleotide sequence ID" value="XM_003896978.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NKM0"/>
    <dbReference type="SMR" id="A0A096NKM0"/>
    <dbReference type="Ensembl" id="ENSPANT00000009865.3">
        <property type="protein sequence ID" value="ENSPANP00000013527.2"/>
        <property type="gene ID" value="ENSPANG00000007366.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017102"/>
    <dbReference type="KEGG" id="panu:101017102"/>
    <dbReference type="CTD" id="389362"/>
    <dbReference type="eggNOG" id="ENOG502S31R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011804"/>
    <dbReference type="HOGENOM" id="CLU_138031_0_0_1"/>
    <dbReference type="OrthoDB" id="368507at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007366">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NKM0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013527.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="123" mass="13747" checksum="14F98C1BC005B7F4" modified="2018-02-28" version="2">MEGLVAAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYDSIPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLR7</accession>
    <name>A0A096NLR7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase TRIM39</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase TRIM39</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Tripartite motif-containing protein 39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">TRIM39</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="RefSeq" id="XP_009202983.1">
        <property type="nucleotide sequence ID" value="XM_009204719.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202984.1">
        <property type="nucleotide sequence ID" value="XM_009204720.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202985.1">
        <property type="nucleotide sequence ID" value="XM_009204721.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813231.1">
        <property type="nucleotide sequence ID" value="XM_017957742.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813232.1">
        <property type="nucleotide sequence ID" value="XM_017957743.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813233.1">
        <property type="nucleotide sequence ID" value="XM_017957744.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813236.1">
        <property type="nucleotide sequence ID" value="XM_017957747.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792345.1">
        <property type="nucleotide sequence ID" value="XM_021936653.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLR7"/>
    <dbReference type="SMR" id="A0A096NLR7"/>
    <dbReference type="Ensembl" id="ENSPANT00000006482.3">
        <property type="protein sequence ID" value="ENSPANP00000013925.3"/>
        <property type="gene ID" value="ENSPANG00000000655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021948"/>
    <dbReference type="KEGG" id="panu:101021948"/>
    <dbReference type="CTD" id="56658"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154126"/>
    <dbReference type="HOGENOM" id="CLU_013137_0_3_1"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000655">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLR7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19780">
        <property type="entry name" value="Bbox2_TRIM39-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13745">
        <property type="entry name" value="SPRY_PRY_TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000171">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035033">
        <property type="entry name" value="PRY/SPRY_TRIM39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="26">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="27">
        <location>
            <begin position="289"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013925.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="488" mass="56374" checksum="102AA8E5C8786A3E" modified="2022-05-25" version="3">MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMG6</accession>
    <name>A0A096NMG6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein fem-1 homolog B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">FEM1-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FEM1B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter FEM1B. Homooligomer. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1. Interacts with NKX3-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the fem-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901161.1">
        <property type="nucleotide sequence ID" value="XM_003901112.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NMG6"/>
    <dbReference type="SMR" id="A0A096NMG6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014175"/>
    <dbReference type="Ensembl" id="ENSPANT00000010319.3">
        <property type="protein sequence ID" value="ENSPANP00000014175.1"/>
        <property type="gene ID" value="ENSPANG00000016581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020930"/>
    <dbReference type="KEGG" id="panu:101020930"/>
    <dbReference type="CTD" id="10116"/>
    <dbReference type="eggNOG" id="KOG0508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161115"/>
    <dbReference type="HOGENOM" id="CLU_020042_1_0_1"/>
    <dbReference type="OMA" id="ISTKTTC"/>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016581">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NMG6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005123">
        <property type="term" value="F:death receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060442">
        <property type="term" value="P:branching involved in prostate gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060743">
        <property type="term" value="P:epithelial cell maturation involved in prostate gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902041">
        <property type="term" value="P:regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140627">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000205">
        <property type="entry name" value="Fem-1 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000117">
        <property type="entry name" value="Protein fem-1 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF78">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="483"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="627" mass="70264" checksum="85DA943663A988C1" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMW2</accession>
    <name>A0A096NMW2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Cholinergic receptor nicotinic alpha 3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CHRNA3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NMW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014322"/>
    <dbReference type="Ensembl" id="ENSPANT00000012216.3">
        <property type="protein sequence ID" value="ENSPANP00000014322.2"/>
        <property type="gene ID" value="ENSPANG00000015818.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158487"/>
    <dbReference type="HOGENOM" id="CLU_018074_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015818">
        <property type="expression patterns" value="Expressed in pineal body and 51 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098878">
        <property type="term" value="C:neurotransmitter receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19016">
        <property type="entry name" value="LGIC_ECD_nAChR_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000008">
        <property type="entry name" value="Cholinergic receptor nicotinic alpha 6 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339292" evidence="18">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="240"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014322.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="481" mass="54985" checksum="7389A6ACB301FD99" modified="2022-05-25" version="2">MGSRPLSPPRLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSNPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGTEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWMPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLSGAELSNLNCFSRAESKGCKEGYPCQDRMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEEQKAQEIQQLKRKEKSTETSDQEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMX6</accession>
    <name>A0A096NMX6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type zinc finger protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Zinc finger A20 domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZFAND6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NN39</accession>
    <name>A0A096NN39_PAPAN</name>
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        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRPS11</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901394.1">
        <property type="nucleotide sequence ID" value="XM_003901345.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NN39"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014399"/>
    <dbReference type="Ensembl" id="ENSPANT00000011748.3">
        <property type="protein sequence ID" value="ENSPANP00000014399.1"/>
        <property type="gene ID" value="ENSPANG00000011753.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014533"/>
    <dbReference type="KEGG" id="panu:101014533"/>
    <dbReference type="CTD" id="64963"/>
    <dbReference type="eggNOG" id="KOG0408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016068"/>
    <dbReference type="HOGENOM" id="CLU_072439_1_0_1"/>
    <dbReference type="OMA" id="DNTPHPH"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011753">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000006">
        <property type="entry name" value="28S ribosomal protein S11, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003698">
        <property type="entry name" value="PRK05309.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="194" mass="20895" checksum="BA9F724798993B16" modified="2014-11-26" version="1">MQAVRNVGSWFLRSWTWPQTTGVVARTPARTIHTDARQLQDAAAKQEDEEKKAAPSHTRFSIYPPIPGEESSLRWAGKKFEEIPIAHIKASYNNTQIQVVSASNEPLARASCGTEGFRNSKKGTGIAAQTAGVAAAAKATQKGVTHIRVVVKGLGPGRLSAIHGLTMGGLEVISITDNTPIPHNGCRPRKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NT83</accession>
    <name>A0A096NT83_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endoplasmic reticulum membrane protein complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ER membrane protein complex subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EMC7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NT83"/>
    <dbReference type="SMR" id="A0A096NT83"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016254"/>
    <dbReference type="Ensembl" id="ENSPANT00000010698.4">
        <property type="protein sequence ID" value="ENSPANP00000016254.2"/>
        <property type="gene ID" value="ENSPANG00000019866.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017490"/>
    <dbReference type="HOGENOM" id="CLU_073620_1_1_1"/>
    <dbReference type="OMA" id="EMENMQM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019866">
        <property type="expression patterns" value="Expressed in pineal body and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014136991" description="Endoplasmic reticulum membrane protein complex subunit 7" evidence="12">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="13">
        <location>
            <begin position="57"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016254.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="242" mass="26471" checksum="A71930B89A4C2458" modified="2018-02-28" version="2">MAAALWGFFPVLLLLLLSGDVQSSEVPGAAAEGSGGSGVGIGDRFKIEGRAVVPGVKPQDWISAARVLVDGEEHVGFLKTDGSFVVHDIPSGSYVVEVVSPAYRFDPVRVDITSKGKMRARYVNYIKTSEVVRLPYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMMMVLPLLIFVLLPKVVNTSDPDMRREMEQSMNMLNSNHELPDVSEFMTRLFSSKSSGKSSSGSSKTGKSGAGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NW75</accession>
    <name>A0A096NW75_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mesenchyme homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MEOX2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021791665.2">
        <property type="nucleotide sequence ID" value="XM_021935973.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NW75"/>
    <dbReference type="SMR" id="A0A096NW75"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017300"/>
    <dbReference type="Ensembl" id="ENSPANT00000007316.3">
        <property type="protein sequence ID" value="ENSPANP00000017300.3"/>
        <property type="gene ID" value="ENSPANG00000025372.3"/>
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    <dbReference type="GeneID" id="101003593"/>
    <dbReference type="KEGG" id="panu:101003593"/>
    <dbReference type="CTD" id="4223"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154018"/>
    <dbReference type="HOGENOM" id="CLU_081326_0_0_1"/>
    <dbReference type="OMA" id="QHHASWH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Bgee" id="ENSPANG00000025372">
        <property type="expression patterns" value="Expressed in subcutaneous adipose tissue and 30 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090051">
        <property type="term" value="P:negative regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:skeletal muscle tissue development"/>
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        <property type="term" value="P:somite specification"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeobox protein MOX-2"/>
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    <dbReference type="Gene3D" id="1.10.10.60">
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        <property type="entry name" value="HD"/>
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    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
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        <property type="entry name" value="Homeobox_CS"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
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    <dbReference type="SUPFAM" id="SSF46689">
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    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
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    <feature type="DNA-binding region" description="Homeobox" evidence="9">
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        <location>
            <begin position="281"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="11">
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            <begin position="63"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="86"/>
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    <sequence length="303" mass="33457" checksum="809C68BCD090023D" modified="2022-05-25" version="3">MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSLANEDSHDSDHSSEHAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWY0</accession>
    <name>A0A096NWY0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UbiA prenyltransferase domain-containing protein 1</fullName>
            <ecNumber evidence="14">2.5.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UBIAD1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>menadiol + (2E,6E,10E)-geranylgeranyl diphosphate = menaquinol-4 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:74083"/>
            <dbReference type="ChEBI" id="CHEBI:6746"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:193091"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:74084"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with HMGCR and SOAT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="14"/>
    <dbReference type="RefSeq" id="XP_003891157.1">
        <property type="nucleotide sequence ID" value="XM_003891108.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWY0"/>
    <dbReference type="SMR" id="A0A096NWY0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017570"/>
    <dbReference type="Ensembl" id="ENSPANT00000016829.3">
        <property type="protein sequence ID" value="ENSPANP00000017570.1"/>
        <property type="gene ID" value="ENSPANG00000007059.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015401"/>
    <dbReference type="KEGG" id="panu:101015401"/>
    <dbReference type="CTD" id="29914"/>
    <dbReference type="eggNOG" id="KOG4581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012439"/>
    <dbReference type="HOGENOM" id="CLU_043611_0_0_1"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007059">
        <property type="expression patterns" value="Expressed in pancreas and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWY0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="36785" checksum="92E520E821D4A216" modified="2014-11-26" version="1">MAASQVLGEKINILSGETVKAGDREPLGNDCPEQDRLPQRSWRQKCASYVLALRPWSFSASLTPVALGSALAYRSHGVLDPRLLVGCAVAVLAVHGAGNLVNTYYDFSKGIDHKKSDDRTLVDRILEPQDVVRFGVFLYTLGCVCAACLYCLSPLKLEHLALIYFGGLSGSFLYTGGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDREAGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPAGSLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYP2</accession>
    <name>A0A096NYP2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908436.1">
        <property type="nucleotide sequence ID" value="XM_003908387.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYP2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018205"/>
    <dbReference type="Ensembl" id="ENSPANT00000021882.3">
        <property type="protein sequence ID" value="ENSPANP00000018205.2"/>
        <property type="gene ID" value="ENSPANG00000009921.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022730"/>
    <dbReference type="KEGG" id="panu:101022730"/>
    <dbReference type="CTD" id="54867"/>
    <dbReference type="eggNOG" id="KOG4467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002693"/>
    <dbReference type="HOGENOM" id="CLU_025330_1_0_1"/>
    <dbReference type="OMA" id="NGSAGKW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009921">
        <property type="expression patterns" value="Expressed in pancreas and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NYP2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018205.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="686" mass="76764" checksum="04F0FA26DA78FAC8" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P051</accession>
    <name>A0A096P051_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ectonucleotide pyrophosphatase/phosphodiesterase family member 3</fullName>
            <ecNumber evidence="6">3.1.4.1</ecNumber>
            <ecNumber evidence="20">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Alkaline phosphodiesterase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Dinucleoside polyphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Nucleotide diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Nucleotide pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phosphodiesterase I beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Phosphodiesterase I/nucleotide pyrophosphatase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="42" type="primary">ENPP3</name>
    </gene>
    <organism evidence="42 43">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="42 43" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="42" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="42" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="31">Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:14246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>CTP + H2O = CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27762"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:27763"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>GTP + H2O = GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:29392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:13894"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32039"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:32040"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57553"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>P(1),P(5)-bis(5'-adenosyl) pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58450"/>
            <dbReference type="ChEBI" id="CHEBI:62041"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:32052"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-alpha-D-glucosamine 1-phosphate + UMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29547"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:29548"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>UTP + H2O = UMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:29396"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:23997"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Apical cell membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="6"/>
    <dbReference type="EC" id="3.6.1.9" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A096P051"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018726"/>
    <dbReference type="Ensembl" id="ENSPANT00000027647.3">
        <property type="protein sequence ID" value="ENSPANP00000018726.2"/>
        <property type="gene ID" value="ENSPANG00000006092.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159640"/>
    <dbReference type="HOGENOM" id="CLU_012256_0_1_1"/>
    <dbReference type="OMA" id="LFRCGER"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006092">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P051">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="941" mass="107761" checksum="6C82CDC23C929BBB" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0W3</accession>
    <name>A0A096P0W3_PAPAN</name>
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        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="10" type="primary">PTGR1</name>
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    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A096P0W3"/>
    <dbReference type="Ensembl" id="ENSPANT00000027347.3">
        <property type="protein sequence ID" value="ENSPANP00000018988.3"/>
        <property type="gene ID" value="ENSPANG00000025742.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154810"/>
    <dbReference type="HOGENOM" id="CLU_026673_29_3_1"/>
    <dbReference type="OMA" id="KITCGSI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025742">
        <property type="expression patterns" value="Expressed in urinary bladder and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P0W3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035798">
        <property type="term" value="F:2-alkenal reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018988.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="257" mass="28026" checksum="67B4AD1C15211A2F" modified="2022-05-25" version="3">MAVRLLCSLIKKSNRSAYLRSQSRTSSNSFPPASHLVVALHLSGFYCRIHLPSSFSFDLKLKTVPRCSYVLRMEFFFFFRILAKTLKEGDRMMGQQVARVVESKNADLPKGTIVLTSPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVSAAAGAVGSVVGQIAKLKGCKVVAAAGSDKKVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVESFQTLLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P173</accession>
    <name>A0A096P173_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">cAMP responsive element binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CREB3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003911578.2">
        <property type="nucleotide sequence ID" value="XM_003911529.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P173"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019098"/>
    <dbReference type="Ensembl" id="ENSPANT00000026699.3">
        <property type="protein sequence ID" value="ENSPANP00000019098.3"/>
        <property type="gene ID" value="ENSPANG00000025429.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020406"/>
    <dbReference type="KEGG" id="panu:101020406"/>
    <dbReference type="CTD" id="10488"/>
    <dbReference type="eggNOG" id="KOG0709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160343"/>
    <dbReference type="HOGENOM" id="CLU_047257_0_0_1"/>
    <dbReference type="OMA" id="CLLYHMP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025429">
        <property type="expression patterns" value="Expressed in smooth muscle tissue and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902236">
        <property type="term" value="P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000042">
        <property type="entry name" value="Cyclic AMP-responsive element-binding protein 3-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051381">
        <property type="entry name" value="CREB_ATF_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996">
        <property type="entry name" value="AGAP001464-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996:SF4">
        <property type="entry name" value="CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="16">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019098.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="372" mass="41760" checksum="DBF7D7732A59EB7E" modified="2022-05-25" version="3">MELELDAGDQDLLGFLLEESGDLRTAPDESVRAPLDWELPLSEVPSDWEVDDLLSSLLSPPASSLNVLSNSNPCLVHHDHTYSLPREPVSMDLESESCRKEGTQMTPQHMEELAEQDIVRLVLTDEEKSLLEKEGLILPETLPLTKMEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLHQLRKLQAMVIEISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSENPYQLELPALQSEVPKDSTHQWLDSSDHVLQAPGNSSCLLYYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1B3</accession>
    <name>A0A096P1B3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sperm microtubule inner protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPMIP6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096P1B3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019138"/>
    <dbReference type="Ensembl" id="ENSPANT00000026087.3">
        <property type="protein sequence ID" value="ENSPANP00000019138.2"/>
        <property type="gene ID" value="ENSPANG00000025321.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009610"/>
    <dbReference type="KEGG" id="panu:101009610"/>
    <dbReference type="CTD" id="84688"/>
    <dbReference type="eggNOG" id="ENOG502QRFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000945"/>
    <dbReference type="HOGENOM" id="CLU_093197_0_0_1"/>
    <dbReference type="OMA" id="QTMERHV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025321">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 28 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P1B3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028195">
        <property type="entry name" value="SPMIP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35664">
        <property type="entry name" value="SPERMATID-SPECIFIC MANCHETTE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35664:SF1">
        <property type="entry name" value="SPERMATID-SPECIFIC MANCHETTE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15181">
        <property type="entry name" value="SMRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019138.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="262" mass="29920" checksum="AA349E047E64DCE5" modified="2018-02-28" version="2">MFLFSRKTKTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLTPGLTHTMEQHVDPEALQKMAKCAVQDYTYRGSISGHPYLPEKYWLSQEEADKCSPNYLGSDRYNTWRMEPYNSSCCNKYTTYLPRLPKEAGMETAVRGMPLECPPKPERLNAYEREVMVNMLNSLSRNQQLPRITPRCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGAPCTDRRLRPWCRELPTLCTSLRAPARNAVCCYNSPAVILPISEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1J1</accession>
    <name>A0A096P1J1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich adaptor protein 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LURAP1L</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="LEUCINE RICH ADAPTOR PROTEIN 1-LIKE"/>
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            <begin position="28"/>
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            <begin position="44"/>
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            <begin position="56"/>
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            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="227" mass="24362" checksum="07A4F3FF0F0C6C17" modified="2014-11-26" version="1">MEDNPLPDLRDIELKLGRKVPESLVRSLRGEEPVPRERDRDPCGGSGGGGGGGGCSSSSSCCSFPPSLSSSSSSSPTSGSPRGSHSSALERLETKLHLLRQEMINLRATDVRLMRQLLVINESIESIKWMIEEKATITSRGSSLSGSLCSLLESQSTSLRGSYNSLHDSSDGLDGISVGSYLDTLADDVPGHQTPSDLDQFSDSSLIEDPQALHKRPKLDSDYYCFG</sequence>
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    <accession>A0A096P2P0</accession>
    <name>A0A096P2P0_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">G protein pathway suppressor 2</fullName>
        </submittedName>
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        <name evidence="2" type="primary">GPS2</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <property type="gene ID" value="ENSPANG00000024187.3"/>
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        <property type="expression patterns" value="Expressed in aorta and 66 other cell types or tissues"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <sequence length="327" mass="36689" checksum="AE65DA578C978C9B" modified="2014-11-26" version="1">MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEMEERMSLEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPAVQYLSQPQPQPYAVHGHFQPTQTGFLQPGGALSLQKQMEHANQQTGFSDSSSLRPMHPQALHPAPGLLASPQLPVQMQPAGKSGFAATSQPGPRLPFIQHSQNPRFYHK</sequence>
</entry>
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            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096P2P4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019619"/>
    <dbReference type="Ensembl" id="ENSPANT00000023321.3">
        <property type="protein sequence ID" value="ENSPANP00000019619.3"/>
        <property type="gene ID" value="ENSPANG00000024191.3"/>
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    <dbReference type="eggNOG" id="KOG0199">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000162159"/>
    <dbReference type="HOGENOM" id="CLU_000288_7_39_1"/>
    <dbReference type="OMA" id="IMMNLEH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Bgee" id="ENSPANG00000024191">
        <property type="expression patterns" value="Expressed in cornea and 35 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09539">
        <property type="entry name" value="SAM_TNK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14328">
        <property type="entry name" value="UBA_TNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000619">
        <property type="entry name" value="non-receptor tyrosine-protein kinase TNK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000243">
        <property type="entry name" value="Non-receptor tyrosine-protein kinase TNK1 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.200.20:FF:000400">
        <property type="entry name" value="Tyrosine kinase non receptor 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR049587">
        <property type="entry name" value="TNK-like_SAM"/>
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    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
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    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
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        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="116"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="380"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="448"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019619.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="666" mass="72445" checksum="C7E545AFADC1944F" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3K7</accession>
    <name>A0A096P3K7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat domain 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WDR97</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSPANT00000021254.3">
        <property type="protein sequence ID" value="ENSPANP00000019932.2"/>
        <property type="gene ID" value="ENSPANG00000023189.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164199"/>
    <dbReference type="HOGENOM" id="CLU_244603_0_0_1"/>
    <dbReference type="OMA" id="TWFKELF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023189">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019932.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1624" mass="180426" checksum="DB08E6808FB4C16E" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MV28</accession>
    <name>A0A0A0MV28_PAPAN</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">AKT2</name>
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    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0A0MV28"/>
    <dbReference type="Ensembl" id="ENSPANT00000011998.3">
        <property type="protein sequence ID" value="ENSPANP00000004895.3"/>
        <property type="gene ID" value="ENSPANG00000007275.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157189"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007275">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MV28">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01241">
        <property type="entry name" value="PH_PKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05595">
        <property type="entry name" value="STKc_PKB_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000033">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000027">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000838">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034677">
        <property type="entry name" value="Akt2"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039026">
        <property type="entry name" value="PH_PKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="152"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="410"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004895.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="481" mass="55690" checksum="A13C5FCD0D88E911" modified="2022-05-25" version="2">GAWIFVVKNSWKESRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LFJ3</accession>
    <name>A0A2I3LFJ3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THAP domain containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">THAP8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031515468.1">
        <property type="nucleotide sequence ID" value="XM_031659608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LFJ3"/>
    <dbReference type="Ensembl" id="ENSPANT00000035650.2">
        <property type="protein sequence ID" value="ENSPANP00000022221.2"/>
        <property type="gene ID" value="ENSPANG00000035638.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101019976"/>
    <dbReference type="KEGG" id="panu:101019976"/>
    <dbReference type="CTD" id="199745"/>
    <dbReference type="GeneTree" id="ENSGT00940000163335"/>
    <dbReference type="OMA" id="HMGHEDW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035638">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022221.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="274" mass="29795" checksum="E98C844BA0CDC913" modified="2022-05-25" version="2">MPKYCTAPNCSNTAGSLGADNRPVSFYKFPLKDGPRLQAWLRHMGREHWVPSCHQHLCSEHFTPSCFQWRWGVRYLRPDAVPSIFSQAPPAKSQQRTQRTQKPVSPPPPLQEKTPLPQGPAIPVSDPVRLVVLDPTSGSPETAATMLLTPLAPAATPEGSQPEVPAQQAQTGLGSVLGALQRRVQRLQRCQEQHQAQLQALERLAQQLHGESLLARACRGLQRLTTAQTLGPEESQMFTIICGGPDIAVVLAQGPAPATVDAKPELLDTRTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LJ15</accession>
    <name>A0A2I3LJ15_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031523690.1">
        <property type="nucleotide sequence ID" value="XM_031667830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LJ15"/>
    <dbReference type="SMR" id="A0A2I3LJ15"/>
    <dbReference type="Ensembl" id="ENSPANT00000045858.2">
        <property type="protein sequence ID" value="ENSPANP00000023435.2"/>
        <property type="gene ID" value="ENSPANG00000006422.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010611"/>
    <dbReference type="CTD" id="5527"/>
    <dbReference type="GeneTree" id="ENSGT01030000234620"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006422">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LJ15">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023435.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="524" mass="61001" checksum="C46146403829376A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LMZ0</accession>
    <name>A0A2I3LMZ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Potassium channel subfamily K member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KCNK7</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LMZ0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024800"/>
    <dbReference type="Ensembl" id="ENSPANT00000047538.2">
        <property type="protein sequence ID" value="ENSPANP00000024800.2"/>
        <property type="gene ID" value="ENSPANG00000031772.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161992"/>
    <dbReference type="OMA" id="LPQVCAM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031772">
        <property type="expression patterns" value="Expressed in esophagus and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000154">
        <property type="entry name" value="Potassium channel subfamily K member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005408">
        <property type="entry name" value="2pore_dom_K_chnl_TWIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF31">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01586">
        <property type="entry name" value="TWIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035198436" description="Potassium channel subfamily K member 7" evidence="20">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="21">
        <location>
            <begin position="86"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="21">
        <location>
            <begin position="180"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="17">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR038061-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024800.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="305" mass="31962" checksum="BE02848DDE2E1729" modified="2022-05-25" version="2">MRCLRPWAYGLLVVAHLLTLGLEAVLFQALEGPPACRLQAELRAELAAFQAEHRACLPPGALEELLGTALATQAHRVSSLGNSSEARNWDLPSALLFTASILTTTGYGHMAPLSPGGKAFCMVYAALGLPASLALVATLRHCLLPALSRPGAWVVHWQLSPARAALLQAVALDLLVASSFVLLLALVLWGLQGDCSLLGAVYFCFSSLSTIGLGDLLPGHGRGLHPVIYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSSPVTAENQGGILGQDELALSTLPPAAPASGQAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LU95</accession>
    <name>A0A2I3LU95_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">R3H domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">R3HDM2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
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                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Francis C.F."/>
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                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
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                <person name="Khan N.K."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Newsham I.N."/>
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                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Abraham K.A."/>
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                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
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    <comment type="function">
        <text evidence="29">E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="29">Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 29">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Nucleus</location>
        </subcellularLocation>
        <text evidence="29">Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000027226.2"/>
        <property type="gene ID" value="ENSPANG00000021372.3"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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    </feature>
    <feature type="coiled-coil region" evidence="31">
        <location>
            <begin position="1380"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="32">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1356"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="1424"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1458"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1611"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR001734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027226.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1867" mass="208755" checksum="BC045D2E93F68D32" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M2L6</accession>
    <name>A0A2I3M2L6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RNF146</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
            <location evidence="2 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The WWE domain mediates non-covalent poly(ADP-ribose)-binding.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13">Ubiquitinated; autoubiquitinated.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="RefSeq" id="XP_003898262.1">
        <property type="nucleotide sequence ID" value="XM_003898213.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003898267.1">
        <property type="nucleotide sequence ID" value="XM_003898218.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204403.1">
        <property type="nucleotide sequence ID" value="XM_009206139.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204404.1">
        <property type="nucleotide sequence ID" value="XM_009206140.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M2L6"/>
    <dbReference type="SMR" id="A0A2I3M2L6"/>
    <dbReference type="Ensembl" id="ENSPANT00000057239.2">
        <property type="protein sequence ID" value="ENSPANP00000029953.1"/>
        <property type="gene ID" value="ENSPANG00000003352.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016771"/>
    <dbReference type="KEGG" id="panu:101016771"/>
    <dbReference type="CTD" id="81847"/>
    <dbReference type="GeneTree" id="ENSGT00390000000358"/>
    <dbReference type="HOGENOM" id="CLU_067425_0_0_1"/>
    <dbReference type="OrthoDB" id="10065815at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16546">
        <property type="entry name" value="RING-HC_RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000204">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044110">
        <property type="entry name" value="RING-HC_RNF146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033509">
        <property type="entry name" value="RNF146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="360" mass="38983" checksum="FB6C558C0E4571A5" modified="2022-05-25" version="1">MMAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSENVSSAVVAQHSLTQQRLLVSNANQTVSDRSDQSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M8R6</accession>
    <name>A0A2I3M8R6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Interleukin-17 receptor C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Interleukin-17 receptor-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ZcytoR14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">IL17RC</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer; disulfide-linked. Heterodimer with IL17RA. Heterodimerization with IL17RA is independent of the cytoplasmic tail. Associates with non-glycosylated IL17RA constitutively. Binding of IL17A and IL17F induces association with glycosylated IL17RA. Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer. IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer. IL17RC chain cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes. Interacts (through SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M8R6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000032136"/>
    <dbReference type="Ensembl" id="ENSPANT00000049882.2">
        <property type="protein sequence ID" value="ENSPANP00000032136.2"/>
        <property type="gene ID" value="ENSPANG00000015085.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111286"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015085">
        <property type="expression patterns" value="Expressed in iris and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M8R6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030368">
        <property type="term" value="F:interleukin-17 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071621">
        <property type="term" value="P:granulocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038173">
        <property type="term" value="P:interleukin-17A-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11530:FF:000001">
        <property type="entry name" value="interleukin-17 receptor C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039465">
        <property type="entry name" value="IL-17_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027841">
        <property type="entry name" value="IL-17_rcpt_C/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583:SF12">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15037">
        <property type="entry name" value="IL17_R_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035271820" description="Interleukin-17 receptor C" evidence="17">
        <location>
            <begin position="21"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SEFIR" evidence="18">
        <location>
            <begin position="583"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="739"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079879"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032136.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="787" mass="86202" checksum="7D97E62EAC9C5D62" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MA27</accession>
    <name>A0A2I3MA27_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">VARS2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="RefSeq" id="XP_009203012.2">
        <property type="nucleotide sequence ID" value="XM_009204748.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009203013.2">
        <property type="nucleotide sequence ID" value="XM_009204749.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009203014.2">
        <property type="nucleotide sequence ID" value="XM_009204750.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MA27"/>
    <dbReference type="Ensembl" id="ENSPANT00000051166.2">
        <property type="protein sequence ID" value="ENSPANP00000032597.2"/>
        <property type="gene ID" value="ENSPANG00000018481.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006736"/>
    <dbReference type="CTD" id="57176"/>
    <dbReference type="GeneTree" id="ENSGT00940000159890"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018481">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MA27">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000019">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000120">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000007">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000014">
        <property type="entry name" value="valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF71">
        <property type="entry name" value="VALINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="113"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="779"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032597.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118421" checksum="713FF3D26D456B53" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MBD9</accession>
    <name>A0A2I3MBD9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GRK6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_009207913.1">
        <property type="nucleotide sequence ID" value="XM_009209649.4"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I3MBD9"/>
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        <property type="protein sequence ID" value="ENSPANP00000033046.1"/>
        <property type="gene ID" value="ENSPANG00000020835.3"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
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        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
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        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="STKc_GRK6"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="AGC-kinase_C"/>
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        <property type="entry name" value="GPCR_kinase"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="RGS_subdomain_2"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 6"/>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="14">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000308"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="560" mass="64380" checksum="49A6E13A466BBCEB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MBG3</accession>
    <name>A0A2I3MBG3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gasdermin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GSDMC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gasdermin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MBG3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033087"/>
    <dbReference type="Ensembl" id="ENSPANT00000043229.2">
        <property type="protein sequence ID" value="ENSPANP00000033087.2"/>
        <property type="gene ID" value="ENSPANG00000034742.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183140"/>
    <dbReference type="OMA" id="ISLWITY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034742">
        <property type="expression patterns" value="Expressed in esophagus and 37 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007677">
        <property type="entry name" value="Gasdermin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040460">
        <property type="entry name" value="Gasdermin_pore"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041263">
        <property type="entry name" value="Gasdermin_PUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16399">
        <property type="entry name" value="GASDERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16399:SF21">
        <property type="entry name" value="GASDERMIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04598">
        <property type="entry name" value="Gasdermin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17708">
        <property type="entry name" value="Gasdermin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1210">Necrosis</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Gasdermin pore forming" evidence="13">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Gasdermin PUB" evidence="14">
        <location>
            <begin position="311"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033087.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="504" mass="57082" checksum="AB81C47F74042296" modified="2022-05-25" version="2">MPSMFERISKNLIKEIGSKDLTPVKYLLSATKLRQFVILRKKDSRSSIWGQSDYVPVGFSLNDILEPSSSVPETVVTGPFHFSDIVIQKHKADVSVNVGVEVSVSGEASVDHGCSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYNSSGVNILGKISLWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDEYKISGYCAARSEEWLPSFHTISPTLFNASPKDMKLKPELFLKPKFLRGHLPKYEQVCILPVGRIEESFWQNFKHLQEEVFQKIKTLAQLSKDVQDVVFYSILAMLGDRGALQDLMDMLELDSSGHLDGPGGAILKKLQQDSNRAWFNPKDPILYLLEAIMVLNDIQHDLLACSVEMRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYDLLEECGLRMELDSPRSTWDLEAKMPLSALYGTLSLLQQLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MBI0</accession>
    <name>A0A2I3MBI0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA-binding motif protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RBM10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A). May bind to specific miRNA hairpins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009195742.2">
        <property type="nucleotide sequence ID" value="XM_009197478.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MBI0"/>
    <dbReference type="Ensembl" id="ENSPANT00000035321.2">
        <property type="protein sequence ID" value="ENSPANP00000033118.2"/>
        <property type="gene ID" value="ENSPANG00000013608.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017615"/>
    <dbReference type="KEGG" id="panu:101017615"/>
    <dbReference type="CTD" id="8241"/>
    <dbReference type="GeneTree" id="ENSGT00940000160369"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013608">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MBI0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16167">
        <property type="entry name" value="OCRE_RBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12754">
        <property type="entry name" value="RRM2_RBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000110">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000114">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000005">
        <property type="entry name" value="RNA-binding protein 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035618">
        <property type="entry name" value="RBM10_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034992">
        <property type="entry name" value="RBM10_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="17">
        <location>
            <begin position="781"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="543"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="741"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033118.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="853" mass="94425" checksum="89CB917736534FF7" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MCG0</accession>
    <name>A0A2I3MCG0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prominin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PROM1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898558.2">
        <property type="nucleotide sequence ID" value="XM_003898509.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204824.2">
        <property type="nucleotide sequence ID" value="XM_009206560.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MCG0"/>
    <dbReference type="Ensembl" id="ENSPANT00000036995.2">
        <property type="protein sequence ID" value="ENSPANP00000033447.2"/>
        <property type="gene ID" value="ENSPANG00000007794.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019150"/>
    <dbReference type="KEGG" id="panu:101019150"/>
    <dbReference type="CTD" id="8842"/>
    <dbReference type="GeneTree" id="ENSGT00530000063586"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007794">
        <property type="expression patterns" value="Expressed in renal medulla and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MCG0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071914">
        <property type="term" value="C:prominosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060219">
        <property type="term" value="P:camera-type eye photoreceptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF3">
        <property type="entry name" value="PROMININ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035205205" evidence="9">
        <location>
            <begin position="20"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033447.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="855" mass="96096" checksum="28C42AF67E9C0C25" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGL6</accession>
    <name>A0A2I3MGL6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA-binding protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">RNA-binding motif protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RBM3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003917720.1">
        <property type="nucleotide sequence ID" value="XM_003917671.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195791.1">
        <property type="nucleotide sequence ID" value="XM_009197527.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031516780.1">
        <property type="nucleotide sequence ID" value="XM_031660920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MGL6"/>
    <dbReference type="SMR" id="A0A2I3MGL6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000034725"/>
    <dbReference type="Ensembl" id="ENSPANT00000042923.2">
        <property type="protein sequence ID" value="ENSPANP00000034725.1"/>
        <property type="gene ID" value="ENSPANG00000034727.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101006190"/>
    <dbReference type="KEGG" id="panu:101006190"/>
    <dbReference type="CTD" id="5935"/>
    <dbReference type="GeneTree" id="ENSGT00940000153524"/>
    <dbReference type="OMA" id="FIEMADD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034727">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12449">
        <property type="entry name" value="RRM_CIRBP_RBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000312">
        <property type="entry name" value="RNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034278">
        <property type="entry name" value="RBM3/CIRBP_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="157" mass="17170" checksum="91C12E2A3E32CFA4" modified="2018-02-28" version="1">MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASVAMRAMNGESLDGRQIRVDHAGKSARGTRGGGFGAHGRGRSYSRGGGDQGYGSGRYYDSRPGGYGYGYGRSRDYNGRNQGGYDRYSGGNYRDNYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3ML84</accession>
    <name>A0A2I3ML84_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Signal recognition particle 14 kDa protein</fullName>
            <shortName evidence="11">SRP14</shortName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021792065.2">
        <property type="nucleotide sequence ID" value="XM_021936373.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3ML84"/>
    <dbReference type="STRING" id="9555.ENSPANP00000036455"/>
    <dbReference type="Ensembl" id="ENSPANT00000040555.2">
        <property type="protein sequence ID" value="ENSPANP00000036455.2"/>
        <property type="gene ID" value="ENSPANG00000034490.2"/>
    </dbReference>
    <dbReference type="GeneID" id="103883331"/>
    <dbReference type="KEGG" id="panu:103883331"/>
    <dbReference type="GeneTree" id="ENSGT00390000008496"/>
    <dbReference type="OMA" id="SVTMKRM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034490">
        <property type="expression patterns" value="Expressed in axillary lymph node and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000002">
        <property type="entry name" value="signal recognition particle 14 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036455.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="127" mass="13825" checksum="2DD76DEE6D4FC00D" modified="2022-05-25" version="2">MVVLESEQFLMELTRLFQKCRMSGSVYITLEKYDGRTKPIPKKGTVEGFEPADKCLLRATDGKKKISTVVSSKEVSKFQMAHSNLLRANMDGLKKRDKKNKTKKTKAAPAAAATTATAAATAATAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MQD7</accession>
    <name>A0A2I3MQD7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MQD7"/>
    <dbReference type="Ensembl" id="ENSPANT00000042787.2">
        <property type="protein sequence ID" value="ENSPANP00000037952.2"/>
        <property type="gene ID" value="ENSPANG00000022875.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161420"/>
    <dbReference type="OMA" id="AYNQEDI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022875">
        <property type="expression patterns" value="Expressed in cerebellum and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MQD7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037952.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="147" mass="15859" checksum="FC766407ACA6251C" modified="2022-05-25" version="2">MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAASVPFSIDGLLGGSSRLGAAVSAHPRIRAANSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQKGTAEEGEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MRN7</accession>
    <name>A0A2I3MRN7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Adhesion G protein-coupled receptor F5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">G-protein coupled receptor 116</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ADGRF5</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Adhesion G protein-coupled receptor. In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis. Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation. In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump. As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer; disulfide-linked. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Fragment generates by the processing enzyme furin remains attached to the extracellular N-terminal fragment. Interacts (via N-terminal extracellular domain) with SFTPD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_009205324.3"/>
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        <property type="gene ID" value="ENSPANG00000008646.3"/>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038296.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1383" mass="153897" checksum="1DC530C2A788EDE1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MTM8</accession>
    <name>A0A2I3MTM8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET nuclear proto-oncogene</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003911275.1">
        <property type="nucleotide sequence ID" value="XM_003911226.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MTM8"/>
    <dbReference type="Ensembl" id="ENSPANT00000050263.2">
        <property type="protein sequence ID" value="ENSPANP00000039082.1"/>
        <property type="gene ID" value="ENSPANG00000025900.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997878"/>
    <dbReference type="GeneID" id="101004600"/>
    <dbReference type="KEGG" id="panu:101004600"/>
    <dbReference type="CTD" id="6418"/>
    <dbReference type="GeneTree" id="ENSGT00940000154891"/>
    <dbReference type="OMA" id="WPVALMN"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025900">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MTM8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000003">
        <property type="entry name" value="SET isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000002">
        <property type="entry name" value="Testis-specific Y-encoded-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33505" checksum="F37CF0B41B9A3A70" modified="2018-02-28" version="1">MAPKRQSPLLPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUT4</accession>
    <name>A0A2I3MUT4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neuronal calcium sensor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Frequenin homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUT4"/>
    <dbReference type="Ensembl" id="ENSPANT00000034193.2">
        <property type="protein sequence ID" value="ENSPANP00000039528.2"/>
        <property type="gene ID" value="ENSPANG00000033050.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163010"/>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033050">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008048">
        <property type="term" value="F:calcium sensitive guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039528.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="185" mass="21190" checksum="742C762C86410859" modified="2022-05-25" version="2">MGKSNSKLKPEVVEELTRKTYCEYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVVRGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MY97</accession>
    <name>A0A2I3MY97_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">EH domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">EHD1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="19">Homooligomer, and heterooligomer with EHD2, EHD3 and EHD4, ATP-binding is required for heterooligomerization. Interacts (via EH domain) with MICALL1 (via NPF1 motif); the interaction is direct and recruits EHD1 to membranes. Interacts with RAB35; the interaction is indirect through MICALL1 and recruits EHD1 to membranes. Interacts (via EH domain) with PACSIN2 (via NPF motifs); regulates localization to tubular recycling endosome membranes. Interacts with PACSIN1. Interacts with RAB8A. Interacts with FER1L5 (via second C2 domain). Interacts with MYOF. Interacts with ZFYVE20. Interacts (via EH domain) with RAB11FIP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009183963.1">
        <property type="nucleotide sequence ID" value="XM_009185699.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MY97"/>
    <dbReference type="SMR" id="A0A2I3MY97"/>
    <dbReference type="Ensembl" id="ENSPANT00000036574.2">
        <property type="protein sequence ID" value="ENSPANP00000040581.1"/>
        <property type="gene ID" value="ENSPANG00000023120.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137473"/>
    <dbReference type="CTD" id="10938"/>
    <dbReference type="GeneTree" id="ENSGT00940000158249"/>
    <dbReference type="OMA" id="MRVYIGY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023358">
        <property type="expression patterns" value="Expressed in spleen and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MY97">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020018">
        <property type="term" value="C:ciliary pocket membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031095">
        <property type="term" value="C:platelet dense tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034383">
        <property type="term" value="P:low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010886">
        <property type="term" value="P:positive regulation of cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001137">
        <property type="term" value="P:positive regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901741">
        <property type="term" value="P:positive regulation of myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
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    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF127">
        <property type="entry name" value="EH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="23">
        <location>
            <begin position="69"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="21">
        <location>
            <begin position="458"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00093788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="548" mass="61927" checksum="AA5512BA3C4EE8FD" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MZ47</accession>
    <name>A0A2I3MZ47_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PYM homolog 1, exon junction complex associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PYM1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009179182.1">
        <property type="nucleotide sequence ID" value="XM_009180918.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MZ47"/>
    <dbReference type="Ensembl" id="ENSPANT00000032241.2">
        <property type="protein sequence ID" value="ENSPANP00000040992.1"/>
        <property type="gene ID" value="ENSPANG00000009562.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997604"/>
    <dbReference type="CTD" id="84305"/>
    <dbReference type="GeneTree" id="ENSGT00730000111107"/>
    <dbReference type="OMA" id="IPGCADS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009562">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MZ47">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="204" mass="22664" checksum="A5B8FB60505B04FE" modified="2018-02-28" version="1">MEAAGNPAATETGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATAPVTPSRPEGGEPGLSKTAKRNLKRKEKRRQQQEKGEAEALSRTLDKVSLEETAQPPNAPQGSRAAPTAASDQPDSAATAEKAKKIKNLKKKLRQVEELQQRIQAGEVSQPSKEQLEKLARRRALEEELEDLELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N5F2</accession>
    <name>A0A2I3N5F2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar fusion protein MON1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MON1B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in membrane trafficking through the secretory apparatus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917253.1">
        <property type="nucleotide sequence ID" value="XM_003917204.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195166.1">
        <property type="nucleotide sequence ID" value="XM_009196902.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N5F2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000043250"/>
    <dbReference type="Ensembl" id="ENSPANT00000046227.2">
        <property type="protein sequence ID" value="ENSPANP00000043250.1"/>
        <property type="gene ID" value="ENSPANG00000018516.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021867"/>
    <dbReference type="KEGG" id="panu:101021867"/>
    <dbReference type="CTD" id="22879"/>
    <dbReference type="GeneTree" id="ENSGT00390000006665"/>
    <dbReference type="OMA" id="TKTCAIT"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018516">
        <property type="expression patterns" value="Expressed in bone marrow and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N5F2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019085">
        <property type="term" value="P:early viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019086">
        <property type="term" value="P:late viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF13">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="4">
        <location>
            <begin position="110"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="5">
        <location>
            <begin position="276"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="6">
        <location>
            <begin position="409"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="547" mass="59233" checksum="39BF60112197E8E7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NBF4</accession>
    <name>A0A2I3NBF4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NBF4"/>
    <dbReference type="Ensembl" id="ENSPANT00000049082.2">
        <property type="protein sequence ID" value="ENSPANP00000045331.2"/>
        <property type="gene ID" value="ENSPANG00000030038.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164205"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014696">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NBF4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF158">
        <property type="entry name" value="KRAB DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045331.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="109" mass="12943" checksum="53105424CF9F2C3D" modified="2022-05-25" version="2">MAFTQLTFRDVAIEFSQEEWKCLNSTQRTLYRDVMLENYRNLVSLEYYLMWEHRKEPWTMESQVQIARKPKGWEWIKGVKIGWSVIAQSQLTATTASRIQMILLPQSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NF46</accession>
    <name>A0A2I3NF46_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="15">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CDC25B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms seem to have a different level of activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with MAPK14 and 14-3-3 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3NF46"/>
    <dbReference type="Ensembl" id="ENSPANT00000044794.2">
        <property type="protein sequence ID" value="ENSPANP00000046607.1"/>
        <property type="gene ID" value="ENSPANG00000014237.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158524"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014237">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NF46">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000006">
        <property type="entry name" value="M-phase inducer phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF48">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06617">
        <property type="entry name" value="M-inducer_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 15" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 15" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="17">
        <location>
            <begin position="390"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="539" mass="61041" checksum="53795539A12A7D75" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NHI2</accession>
    <name>A0A2I3NHI2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Potassium voltage-gated channel subfamily Q member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">KCNQ2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021777481.2">
        <property type="nucleotide sequence ID" value="XM_021921789.2"/>
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    <dbReference type="Ensembl" id="ENSPANT00000048741.2">
        <property type="protein sequence ID" value="ENSPANP00000047444.2"/>
        <property type="gene ID" value="ENSPANG00000024128.3"/>
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    <dbReference type="GeneID" id="101017163"/>
    <dbReference type="CTD" id="3785"/>
    <dbReference type="GeneTree" id="ENSGT00940000160093"/>
    <dbReference type="OMA" id="TSWQPQG"/>
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        <property type="component" value="Chromosome 16"/>
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    <dbReference type="Bgee" id="ENSPANG00000024128">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 35 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3NHI2">
        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030506">
        <property type="term" value="F:ankyrin binding"/>
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    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:voltage-gated potassium channel activity"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Ankyrin-G_BS"/>
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        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
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        <property type="entry name" value="K_chnl_volt-dep_KCNQ2"/>
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        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
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        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2"/>
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        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16642">
        <property type="entry name" value="KCNQ2_u3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF11956">
        <property type="entry name" value="KCNQC3-Ank-G_bd"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KCHANNEL"/>
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        <property type="entry name" value="KCNQ2CHANNEL"/>
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        <property type="entry name" value="KCNQCHANNEL"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="293"/>
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    </feature>
    <feature type="domain" description="Ion transport" evidence="21">
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            <begin position="96"/>
            <end position="321"/>
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    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="22">
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            <begin position="466"/>
            <end position="649"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="403"/>
            <end position="422"/>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="439"/>
            <end position="488"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="598"/>
            <end position="618"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="659"/>
            <end position="680"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="693"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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            <begin position="838"/>
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            <begin position="458"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
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    <feature type="compositionally biased region" description="Polar residues" evidence="19">
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    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03520"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NI74</accession>
    <name>A0A2I3NI74_PAPAN</name>
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        <recommendedName>
            <fullName evidence="31">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
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        <name evidence="33" type="primary">SLC1A5</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>D-serine(in) + L-alanine(out) + Na(+)(out) = D-serine(out) + L-alanine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75311"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75307"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70859"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70891"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-glutamine(in) + L-alanine(out) + Na(+)(out) = L-glutamine(out) + L-alanine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70867"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-glutamine(in) + L-glutamate(out) + Na(+)(out) + H(+)(out) = L-glutamine(out) + L-glutamate(in) + Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70883"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70875"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70887"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70855"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70863"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonine(out) + L-glutamine(in) + Na(+)(out) = L-threonine(in) + L-glutamine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70879"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-valine(out) + L-glutamine(in) + Na(+)(out) = L-valine(in) + L-glutamine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70871"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>nitrate(in) = nitrate(out)</text>
            <dbReference type="Rhea" id="RHEA:34923"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>thiocyanate(in) = thiocyanate(out)</text>
            <dbReference type="Rhea" id="RHEA:75347"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Membrane</location>
            <topology evidence="31">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="31">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031514986.1">
        <property type="nucleotide sequence ID" value="XM_031659126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NI74"/>
    <dbReference type="STRING" id="9555.ENSPANP00000047620"/>
    <dbReference type="Ensembl" id="ENSPANT00000057666.2">
        <property type="protein sequence ID" value="ENSPANP00000047620.1"/>
        <property type="gene ID" value="ENSPANG00000024227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019511"/>
    <dbReference type="KEGG" id="panu:101019511"/>
    <dbReference type="CTD" id="6510"/>
    <dbReference type="GeneTree" id="ENSGT00940000159485"/>
    <dbReference type="OMA" id="VGTFYAT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024227">
        <property type="expression patterns" value="Expressed in mesenteric fat pad and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NI74">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140009">
        <property type="term" value="P:L-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070207">
        <property type="term" value="P:protein homotrimerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3860.10:FF:000005">
        <property type="entry name" value="Amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF19">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER B(0)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="9 31" id="KW-0769">Symport</keyword>
    <keyword evidence="7 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 31" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="542" mass="56722" checksum="709C87741BA5DE4B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MVX0</accession>
    <name>A0A8I5MVX0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MVX0"/>
    <dbReference type="Ensembl" id="ENSPANT00000070649.1">
        <property type="protein sequence ID" value="ENSPANP00000048169.1"/>
        <property type="gene ID" value="ENSPANG00000046461.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="OMA" id="CARPENF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF133">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="11278" checksum="3094D860D667E1D5" modified="2022-05-25" version="1">DGVSLLLPGLECNGAISGLPQPPPPGFKQFSLLSLQSSWVYRPPHPANFVFLVETGFLHVGQDGLKLHTSGDLPTSASQSAGITGVSHCARPENFFFLEMGSHYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXQ0</accession>
    <name>A0A8I5MXQ0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sin3A associated protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SAP30</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899417.1">
        <property type="nucleotide sequence ID" value="XM_003899368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXQ0"/>
    <dbReference type="SMR" id="A0A8I5MXQ0"/>
    <dbReference type="Ensembl" id="ENSPANT00000082332.1">
        <property type="protein sequence ID" value="ENSPANP00000049478.1"/>
        <property type="gene ID" value="ENSPANG00000005972.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998955"/>
    <dbReference type="KEGG" id="panu:100998955"/>
    <dbReference type="CTD" id="8819"/>
    <dbReference type="GeneTree" id="ENSGT00390000006633"/>
    <dbReference type="OMA" id="DEYRICC"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025717">
        <property type="entry name" value="SAP30_zn-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF7">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13866">
        <property type="entry name" value="zf-SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 zinc-finger" evidence="12">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="13">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="220" mass="23320" checksum="52162F2E6885DD7A" modified="2022-05-25" version="1">MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGAGAEVPGAGTVSVAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDVKVDSGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXV3</accession>
    <name>A0A8I5MXV3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXV3"/>
    <dbReference type="Ensembl" id="ENSPANT00000076498.1">
        <property type="protein sequence ID" value="ENSPANP00000050620.1"/>
        <property type="gene ID" value="ENSPANG00000042041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="OMA" id="CMSHYAR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF151">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035149920" evidence="1">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="120" mass="12712" checksum="95C45A8B01CEAB92" modified="2022-05-25" version="1">MQAPVSIPSSSFLKIIYIFIYFRQSLALLPGLECNGMILGDCNLCLPGASNSSASASQVVGITGACHHAWLIFVFLVEMGFHHVGQAGLKLLTSSDLPASASQSAGITCMSHYARPHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MYY9</accession>
    <name>A0A8I5MYY9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MYY9"/>
    <dbReference type="Ensembl" id="ENSPANT00000068087.1">
        <property type="protein sequence ID" value="ENSPANP00000050342.1"/>
        <property type="gene ID" value="ENSPANG00000043550.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005727"/>
    <dbReference type="OMA" id="LAYPMEN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18272" checksum="E6E342DF5B7A942D" modified="2022-05-25" version="1">MLWLPTVFRQMRPVSRVLTPHLTRAYAKDVKFGADARALMLQGADLLADAVAVTMGPKGRTVIIEQSWGSPRVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLACSIAKEGFEKISKGANLVEIRRGCENCFTGCCWCGLSVNYSRSCSPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZA8</accession>
    <name>A0A8I5MZA8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metaxin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mitochondrial outer membrane import complex protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in transport of proteins into the mitochondrion. Essential for embryonic development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with MTX2/metaxin-2. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with ARMC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZA8"/>
    <dbReference type="Ensembl" id="ENSPANT00000061592.1">
        <property type="protein sequence ID" value="ENSPANP00000048288.1"/>
        <property type="gene ID" value="ENSPANG00000043687.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182919"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03212">
        <property type="entry name" value="GST_C_Metaxin1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF34">
        <property type="entry name" value="METAXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="18">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="467" mass="52056" checksum="B6B8669DC2496A5B" modified="2022-05-25" version="1">MGRRPPSPEARGPVPRSSAASRTRRSLASPGTSPGPLTATTGGAVVGGGSVQGRAGAHKEVFPGQRAGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKISNPWRSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGHMQWQYMERLELLSGEHMPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLLQAKLPSGKLQAHLRGLHNLCAYCTHILSLYFPWDGGKGQMGGAALGRVGRDLRTSSPNSPSFLDPQLRYHRHARHQQAQRLRRSHTGAGTRSYLCWQDWQPWWATPCSAALSPSSGQRLLGPQAPGPWAWLRRMKRNDLSSRSQDWFFYSRAFQRPPCLLFVGTAGHGVLPPRIKPLTLTGLKHFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1F0</accession>
    <name>A0A8I5N1F0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N1F0"/>
    <dbReference type="Ensembl" id="ENSPANT00000080926.1">
        <property type="protein sequence ID" value="ENSPANP00000049364.1"/>
        <property type="gene ID" value="ENSPANG00000045565.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="OMA" id="RYLGDLC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204266" evidence="1">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="108" mass="12032" checksum="BCA5E48A8933C876" modified="2022-05-25" version="1">PRYLGDLCKKSPLNPQLFFFFFFFLRRSLALSPRLECSGAISAHCKLRLPGSRHSPASASRVAGTTGARHRARLIFCIFSRDGVSPWSRSPDLVIRPPRPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N6R7</accession>
    <name>A0A8I5N6R7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-B-cell leukemia transcription factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17 18">Homeobox protein PBX1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PBX1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a heterodimer with MEIS1 which binds DNA. The PBX1-MEIS1 heterodimer binds a cAMP-responsive sequence in CYP17. It also binds a consensus region in the SOX3 promoter. PBX1 forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Forms heterodimers with HOXA1, HOXA5, HOXB7 and HOXB8 which bind the 5'-TGATTGAT-3' consensus sequence. Also forms heterodimers with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 which bind the 5'-ATCAATCAA-3' consensus sequence. Interacts with PBXIP1. Interacts with TLX1. Interacts with FOXC1. Interacts with MN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of a PDX1:PBX1b:MEIS2B complex; PBX1b recruits MEIS2B to the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/PBX homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009191073.2">
        <property type="nucleotide sequence ID" value="XM_009192809.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N6R7"/>
    <dbReference type="SMR" id="A0A8I5N6R7"/>
    <dbReference type="Ensembl" id="ENSPANT00000072814.1">
        <property type="protein sequence ID" value="ENSPANP00000052876.1"/>
        <property type="gene ID" value="ENSPANG00000012912.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012778"/>
    <dbReference type="KEGG" id="panu:101012778"/>
    <dbReference type="CTD" id="5087"/>
    <dbReference type="GeneTree" id="ENSGT00940000154374"/>
    <dbReference type="OMA" id="CHRMRHA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030325">
        <property type="term" value="P:adrenal gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035162">
        <property type="term" value="P:embryonic hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000648">
        <property type="term" value="P:positive regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030278">
        <property type="term" value="P:regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001655">
        <property type="term" value="P:urogenital system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000277">
        <property type="entry name" value="Pre-B-cell leukemia transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 19" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PBC" evidence="22">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="21">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="19">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="430" mass="46626" checksum="AD3FFACBC5A9E715" modified="2022-05-25" version="1">MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NB47</accession>
    <name>A0A8I5NB47_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein 195</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NB47"/>
    <dbReference type="Ensembl" id="ENSPANT00000083316.1">
        <property type="protein sequence ID" value="ENSPANP00000058573.1"/>
        <property type="gene ID" value="ENSPANG00000045732.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154251"/>
    <dbReference type="OMA" id="HATQAYL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000034">
        <property type="entry name" value="zinc finger protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000382">
        <property type="entry name" value="zinc finger protein 35 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000672">
        <property type="entry name" value="Zinc finger protein 430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002811">
        <property type="entry name" value="Zinc finger protein 679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF87">
        <property type="entry name" value="ZINC FINGER PROTEIN 195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="386"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72746" checksum="0BAAC8CA54E391A4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBC9</accession>
    <name>A0A8I5NBC9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBC9"/>
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        <property type="protein sequence ID" value="ENSPANP00000058693.1"/>
        <property type="gene ID" value="ENSPANG00000036979.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="QAGMQWP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="76" mass="8536" checksum="DFCE7A95519AB2CE" modified="2022-05-25" version="1">VQWCDLGSLQPPPPGFKRFSCLSLLSSWDYRCLPPRPANFCIFSRDGVSPCWSGWSRTPDLVIHPPRPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC19</accession>
    <name>A0A8I5NC19_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lacritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LACRT</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003906560.2">
        <property type="nucleotide sequence ID" value="XM_003906511.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC19"/>
    <dbReference type="Ensembl" id="ENSPANT00000074592.1">
        <property type="protein sequence ID" value="ENSPANP00000050136.1"/>
        <property type="gene ID" value="ENSPANG00000040904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101007239"/>
    <dbReference type="KEGG" id="panu:101007239"/>
    <dbReference type="CTD" id="90070"/>
    <dbReference type="GeneTree" id="ENSGT00940000163391"/>
    <dbReference type="OMA" id="GKQFFEG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043237">
        <property type="term" value="F:laminin-1 binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010669">
        <property type="term" value="P:epithelial structure maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031665">
        <property type="term" value="P:negative regulation of lipopolysaccharide-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070886">
        <property type="term" value="P:positive regulation of calcineurin-NFAT signaling cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060054">
        <property type="term" value="P:positive regulation of epithelial cell proliferation involved in wound healing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051281">
        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051047">
        <property type="term" value="P:positive regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070075">
        <property type="term" value="P:tear secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043557">
        <property type="entry name" value="Dermcidin/Lacritin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40711">
        <property type="entry name" value="DERMCIDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40711:SF2">
        <property type="entry name" value="EXTRACELLULAR GLYCOPROTEIN LACRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="182" mass="19373" checksum="425A74A2CE0BFB86" modified="2022-05-25" version="1">MWKSHLSKLGSHWPLICLKGPSSFSILIPRTLCRFCGYTHSSSRRMKFTTLLFLAAVAGALVYAEDASSDSTDADPAEEAGTSKPNEEISDPAASASPPETTTTAQETSAAVQGTAKVTSSRQELNPLKSIVEKSILLTEQAFARAGKGMPGGLAGGKQFIENGNEFAQKLLKKFGLPKPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCJ7</accession>
    <name>A0A8I5NCJ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PH and SEC7 domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pleckstrin homology and SEC7 domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PSD4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031511211.1">
        <property type="nucleotide sequence ID" value="XM_031655351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCJ7"/>
    <dbReference type="Ensembl" id="ENSPANT00000067708.1">
        <property type="protein sequence ID" value="ENSPANP00000059732.1"/>
        <property type="gene ID" value="ENSPANG00000025950.3"/>
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        <property type="component" value="Chromosome 14"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phospholipid binding"/>
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        <property type="term" value="P:regulation of ARF protein signal transduction"/>
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        <property type="entry name" value="PH_EFA6"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="13">
        <location>
            <begin position="555"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="767"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="366"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="389"/>
            <end position="478"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="524"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="571"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="426"/>
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            <begin position="436"/>
            <end position="458"/>
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            <begin position="468"/>
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            <begin position="500"/>
            <end position="510"/>
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            <begin position="1034"/>
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    </feature>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114953" checksum="9B9E3303A39D4AEE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NED7</accession>
    <name>A0A8I5NED7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MHC class I-like antigen recognition-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NED7"/>
    <dbReference type="Ensembl" id="ENSPANT00000071750.1">
        <property type="protein sequence ID" value="ENSPANP00000056908.1"/>
        <property type="gene ID" value="ENSPANG00000050994.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271825"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046703">
        <property type="term" value="F:natural killer cell lectin-like receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000004">
        <property type="entry name" value="Retinoic acid early-inducible protein 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059105">
        <property type="entry name" value="Rec21/ENK19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF64">
        <property type="entry name" value="RETINOIC ACID EARLY TRANSCRIPT 1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15695">
        <property type="entry name" value="HERV-K_REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="MHC class I-like antigen recognition-like" evidence="10">
        <location>
            <begin position="125"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rec21/ENK19" evidence="11">
        <location>
            <begin position="327"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46000" checksum="0A1E19C6557A7D82" modified="2022-05-25" version="1">MVGGCPARPASPRPGVSAPQRVCPETLRKKAVTSGLSILETAEGQTSPAGTRPALSCSRVKNLGSAHTHAVEHFFTIPVRVFVSMPNVLPVTLHNVPRMPLTCSPVRLLLLLLLLLTALEIMVGAHSLCFNFTIKSWSRPGQPWCEAQVFMNKNLFLQYNSDSNMVKPLGLLGKKVNATSTWGELTQTLGEVGRDLRMLLLDIKPQIKTSGPSTLQVKMFCQHEVERCTGASWQFAINGEKSLLLDAMNMTWTVINHEACKIKETWKNDRGLEKYFRKLSMGDCNHWLREFSGHWEVMPEPTDIRSSTMNPSEMQRKVPPRRQKTRNRASSTRQVNKMVISEEQMKLPSTKEVEPPTWGQLKELTQLAEKSLKKTRVTHTPENMLLAALMIVSTVSASVSSSSEETATSENGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFP2</accession>
    <name>A0A8I5NFP2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF891</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NFP2"/>
    <dbReference type="Ensembl" id="ENSPANT00000024842.3">
        <property type="protein sequence ID" value="ENSPANP00000056339.1"/>
        <property type="gene ID" value="ENSPANG00000014164.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164587"/>
    <dbReference type="OMA" id="QHKIPEG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000907">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001697">
        <property type="entry name" value="zinc finger protein 623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001734">
        <property type="entry name" value="Zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF390">
        <property type="entry name" value="ZINC FINGER PROTEIN 37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="548" mass="64079" checksum="95A2117833087F6F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFU7</accession>
    <name>A0A8I5NFU7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NFU7"/>
    <dbReference type="Ensembl" id="ENSPANT00000073729.1">
        <property type="protein sequence ID" value="ENSPANP00000053302.1"/>
        <property type="gene ID" value="ENSPANG00000046469.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000146416"/>
    <dbReference type="OMA" id="EMGPHLS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="129" mass="13972" checksum="CBB641F884D6117C" modified="2022-05-25" version="1">MCWGYRGSEHLPHTGRTLAPMFTMLRETFGEQREASRGMGPQLSSIRGRARACLTSLLAAPWAAAPWQLELEGFSESAQPHRSPHSRGWALGDRARAGRKTGPGSPRSSAHEGAQSRAGRSGPLHTQPC</sequence>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGK3</accession>
    <name>A0A8I5NGK3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGK3"/>
    <dbReference type="Ensembl" id="ENSPANT00000002179.3">
        <property type="protein sequence ID" value="ENSPANP00000052130.1"/>
        <property type="gene ID" value="ENSPANG00000001920.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035218654" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16190" checksum="0FB5A2E4DC3511E7" modified="2022-05-25" version="1">MIETIFYFLFLSFFFFFEMESCFFVQAGVQRCNLSSLQPPPPRFKQFSCLSLSSSWDYRCAPPCLANFCIFSRDRVLPRWPGWSRTPDLKRSSHLSLPKCWDYRCEPPHPAGNNIFFFFFLRRSLALSPRLECSGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NIC3</accession>
    <name>A0A8I5NIC3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
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        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIC3"/>
    <dbReference type="Ensembl" id="ENSPANT00000082852.1">
        <property type="protein sequence ID" value="ENSPANP00000059201.1"/>
        <property type="gene ID" value="ENSPANG00000047478.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="176" mass="20107" checksum="5957192D72A32BB2" modified="2022-05-25" version="1">MSGSLKNHFNTFLSSLPFEFDQFILRAYFSDICSLFFLQYFLQYSKERTKQSLKGHRDLGYSMENTKSFVWQSITLSPSLECRGTILAHYRLCLPGSGDRPPLASSVAGTTGMHHHTQVIFVFLVEIGFPHFDQDCLILLTSGDPPTLAFKNSEITSVSHHTQPNYTFLFSLYFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJN9</accession>
    <name>A0A8I5NJN9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NCBP2L</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021788197.1">
        <property type="nucleotide sequence ID" value="XM_021932505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJN9"/>
    <dbReference type="Ensembl" id="ENSPANT00000070584.1">
        <property type="protein sequence ID" value="ENSPANP00000055738.1"/>
        <property type="gene ID" value="ENSPANG00000038499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="108583765"/>
    <dbReference type="KEGG" id="panu:108583765"/>
    <dbReference type="CTD" id="392517"/>
    <dbReference type="GeneTree" id="ENSGT00390000003197"/>
    <dbReference type="OMA" id="LDEWIIR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF5">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="153" mass="17739" checksum="4EA2534516571DC7" modified="2022-05-25" version="1">MSKGLKILCKDPVLELSCCRDHQFSGSKFQQEKLLKESSTMNMRNLSFYTTEEKIHELFSRSDIRNIFMGLDKIKKTACGFCFVECHNRADAENAMRFLNGTCLDEWIIRTDWDIGFREGQQYGRGKSGSQVRDEFREDFHSGRGGFGRQSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKB4</accession>
    <name>A0A8I5NKB4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Taurine up-regulated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TUG1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKB4"/>
    <dbReference type="Ensembl" id="ENSPANT00000064171.1">
        <property type="protein sequence ID" value="ENSPANP00000053169.1"/>
        <property type="gene ID" value="ENSPANG00000045070.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000220689"/>
    <dbReference type="OMA" id="VDRAIGW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047356386" evidence="1">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="153" mass="16006" checksum="8C759B5F23D19842" modified="2025-10-08" version="2">MARPPPLPGLVGRRNGRAVDRAIGWRLFLLLWHPALGAQARPPRRAPGGRWRSRRVFLLVRRTRAAAYAFAIRRGVVRVVGGGGQLLRPAPGEAAAAAAAGFGAAGEAGVAGAGLEAWRHPSGPARTQLGGQEGAGGWLVVGFLLCLFLLMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKG6</accession>
    <name>A0A8I5NKG6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fanconi anemia group F protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FANCF</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003910168.2">
        <property type="nucleotide sequence ID" value="XM_003910119.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKG6"/>
    <dbReference type="Ensembl" id="ENSPANT00000064897.1">
        <property type="protein sequence ID" value="ENSPANP00000053583.1"/>
        <property type="gene ID" value="ENSPANG00000042355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101016505"/>
    <dbReference type="KEGG" id="panu:101016505"/>
    <dbReference type="CTD" id="2188"/>
    <dbReference type="GeneTree" id="ENSGT00390000005623"/>
    <dbReference type="OMA" id="LQWARYL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.490:FF:000001">
        <property type="entry name" value="Fanconi anemia, complementation group F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035428">
        <property type="entry name" value="FANCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038505">
        <property type="entry name" value="FANCF_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14449:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14449">
        <property type="entry name" value="FANCONI ANEMIA GROUP F PROTEIN FANCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11107">
        <property type="entry name" value="FANCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="374" mass="41973" checksum="22F2DABCC55CDFB1" modified="2022-05-25" version="1">MESLLQHLDRFSELLAVSRTAHVRTWDPVTVRRALQWARYLRHIHRRFGRHGPIRTALERRLHNQWRQEGVFGRGPVPGLASFQALGHCDVLLSLRLLENQALGDAARHHLVQQLFPGPGVPDADEETLQESLARLARCGSAVHMLRFNGYRKNLNLQEDSLMKTQADLLLERLQEVGKAEAEGPARFLSSLWERLPQNNFLKVIAVALLQPPLSPRPQEESEPSIHKTPGEGSQALVHWLLGNSEVFAAFCRALPAGLLTLVTSRHPALSPVYLGLLTDWGQRLHYDLQKGIWVGTESQDVPWEELHNRFQSLCQAPPPLKDKVLTALETCKAQDGDFEVPGLSIWTDLLLALRSGAFRKRQVLGLSPGLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLY3</accession>
    <name>A0A8I5NLY3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oocyte secreted protein family member 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OOSP4A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PLAC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLY3"/>
    <dbReference type="Ensembl" id="ENSPANT00000060663.2">
        <property type="protein sequence ID" value="ENSPANP00000059256.1"/>
        <property type="gene ID" value="ENSPANG00000036727.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000193304"/>
    <dbReference type="OMA" id="QDLSITC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033222">
        <property type="entry name" value="PLAC1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14380:SF11">
        <property type="entry name" value="OOCYTE-SECRETED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14380">
        <property type="entry name" value="PLACENTA-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035163512" evidence="5">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="184" mass="21003" checksum="890443E5A3ECDDB6" modified="2022-05-25" version="1">MKISCVLGELLMLFELIHGLQDLSITCSETWLQVKLRRTPLLNDLQPLQNELSLGIGCPVNMVEVDFFGFLYLLTFCGIRVSEHGVGMLIESLIVYEPPNFDFNLHIPVSCYVQRRFPIILVMRRGENDNRRECRRSVGQHCSLSRKLEDLGIRPRVSYVNSVPLLSYLIVSLPKCKNKAIHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMQ8</accession>
    <name>A0A8I5NMQ8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S-phase kinase-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cyclin-A/CDK2-associated protein p19</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">p19skp1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NMQ8"/>
    <dbReference type="Ensembl" id="ENSPANT00000081869.1">
        <property type="protein sequence ID" value="ENSPANP00000057418.1"/>
        <property type="gene ID" value="ENSPANG00000038489.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012652"/>
    <dbReference type="OMA" id="ANMMMCK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="7">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="6">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="115" mass="12969" checksum="5C5F51048F1C65D7" modified="2022-05-25" version="1">MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEADDDPVPLPNVNATILKKAANYLNIKGLLDVTCKTVANMIKGKTPEEIHKTFNIKNDFTEEEEAQVRKENQWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NS11</accession>
    <name>A0A8I5NS11_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NS11"/>
    <dbReference type="Ensembl" id="ENSPANT00000079261.1">
        <property type="protein sequence ID" value="ENSPANP00000059903.1"/>
        <property type="gene ID" value="ENSPANG00000038766.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
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                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
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                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
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                <person name="Tisius J.T."/>
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                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
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                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <source>
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                <person name="Akbar H.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <location>
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        <location>
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        <source>
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        <source>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
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                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUS4"/>
    <dbReference type="Ensembl" id="ENSPANT00000063769.1">
        <property type="protein sequence ID" value="ENSPANP00000061228.1"/>
        <property type="gene ID" value="ENSPANG00000050609.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="176" mass="20212" checksum="2F3D5C8A22E16342" modified="2022-05-25" version="1">GGVFTLSPRLECSGAISAHCKLRLPGPRHSPASASQVAGSTGARHCARLIFFFCIFSRGQGFHHVPGWSRSPDLVIRPSGLPKVHRITGLSHRTLAYFYFFRTDSHSVTQAGVQWHDLSSLLSWDYRCPPPCPVNFCIFIFYYFYLFVFYIYIFIYFIIIFEMESFLYHQAGVQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXD5</accession>
    <name>A0A8I5NXD5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF557</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009191576.1">
        <property type="nucleotide sequence ID" value="XM_009193312.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191577.1">
        <property type="nucleotide sequence ID" value="XM_009193313.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191578.1">
        <property type="nucleotide sequence ID" value="XM_009193314.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191579.1">
        <property type="nucleotide sequence ID" value="XM_009193315.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191581.1">
        <property type="nucleotide sequence ID" value="XM_009193317.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021786296.1">
        <property type="nucleotide sequence ID" value="XM_021930604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NXD5"/>
    <dbReference type="Ensembl" id="ENSPANT00000062699.1">
        <property type="protein sequence ID" value="ENSPANP00000060955.1"/>
        <property type="gene ID" value="ENSPANG00000045372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101011993"/>
    <dbReference type="CTD" id="79230"/>
    <dbReference type="GeneTree" id="ENSGT00940000160844"/>
    <dbReference type="OMA" id="EFNECNQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001532">
        <property type="entry name" value="Zinc finger protein 483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003111">
        <property type="entry name" value="Zinc finger protein 557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="402" mass="45951" checksum="ECDB93C31199A038" modified="2022-05-25" version="1">MAAIILPLTAALPSPFPASQREGHTEGGGLVNELLTSWLKGLVTFEDVAVEFTQEEWALLDPAQRTLYRDVMLENFRNVASLGDQVDKPGLIAQLEQEDKVMTEERGILPGTCPDVENPLKAKGLTPKLHVFRKEQSTNMKMERNHLGAEFNECNQCFKVFSTKSSLMRHKKIHAGEKRYDCSECGKSYSSKSYLTVHKRIHNGEKPYKCSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQCCREFRTQSIFTRHKRVHTGESHYVCNQCGKAFSTGSSLSLHYSIHTGENPYECHNCGKTFRRSSNLTQHVRTHTGEKPYKCNECGISFTSSFSRTVHRRIHNREKSYECSDCGKAFNVLSSVKKHRRTHTGKRPYECNYCGKFFTSNGYLSVHMRTHIRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NZG2</accession>
    <name>A0A8I5NZG2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein disulfide-isomerase TMX3</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Thioredoxin domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Thioredoxin-related transmembrane protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TMX3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003914516.1">
        <property type="nucleotide sequence ID" value="XM_003914467.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NZG2"/>
    <dbReference type="Ensembl" id="ENSPANT00000083986.1">
        <property type="protein sequence ID" value="ENSPANP00000056658.1"/>
        <property type="gene ID" value="ENSPANG00000046821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101004658"/>
    <dbReference type="KEGG" id="panu:101004658"/>
    <dbReference type="CTD" id="54495"/>
    <dbReference type="GeneTree" id="ENSGT00930000151022"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03000">
        <property type="entry name" value="PDI_a_TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000115">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000121">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035242827" description="Protein disulfide-isomerase TMX3" evidence="20">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="21">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="454" mass="51940" checksum="E2383312956CD58E" modified="2022-05-25" version="1">MAAWRSWAALRLCATVVLLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYIGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHARLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQEQIEESKEQQEPSSGESVVPTVQEPKDVLEKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P3B7</accession>
    <name>A0A8I5P3B7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein Aiolos</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Ikaros family zinc finger protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">IKZF3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912992.2">
        <property type="nucleotide sequence ID" value="XM_003912943.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P3B7"/>
    <dbReference type="SMR" id="A0A8I5P3B7"/>
    <dbReference type="Ensembl" id="ENSPANT00000082641.1">
        <property type="protein sequence ID" value="ENSPANP00000060007.1"/>
        <property type="gene ID" value="ENSPANG00000021743.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010812"/>
    <dbReference type="KEGG" id="panu:101010812"/>
    <dbReference type="CTD" id="22806"/>
    <dbReference type="GeneTree" id="ENSGT00940000160462"/>
    <dbReference type="OMA" id="MMQGRMM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007498">
        <property type="term" value="P:mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045577">
        <property type="term" value="P:regulation of B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030888">
        <property type="term" value="P:regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000265">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002057">
        <property type="entry name" value="IKAROS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002372">
        <property type="entry name" value="IKAROS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000080">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN AIOLOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00084063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="509" mass="58137" checksum="4B8C257D56E90213" modified="2022-05-25" version="1">MEDIQTNVELKSTQEQSVPTESPAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKPEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMPNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLPRARNGMPLLKEVPRSYELLKPPPVCPRDSIKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZ48</accession>
    <name>A0A8I5QZ48_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZ48"/>
    <dbReference type="Ensembl" id="ENSPANT00000066545.1">
        <property type="protein sequence ID" value="ENSPANP00000047984.1"/>
        <property type="gene ID" value="ENSPANG00000051163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047984.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="126" mass="14050" checksum="A17400D8B7391681" modified="2022-05-25" version="1">MLKAGSIRLFSHVKDMKGKYLVQVWGRKCIRHSLALSPRLEYSSVISAYCMQPLPPEFKRFSCHSLPSSWDYRYTPPGPANFVFLVEMGFLHVGQAGLELLTSGNPLALPPKVLGLQVGATMPSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R059</accession>
    <name>A0A8I5R059_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R059"/>
    <dbReference type="Ensembl" id="ENSPANT00000080238.1">
        <property type="protein sequence ID" value="ENSPANP00000051419.1"/>
        <property type="gene ID" value="ENSPANG00000046957.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000017927"/>
    <dbReference type="OMA" id="IQTFYFP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="74" mass="8508" checksum="E3F540890B404E0E" modified="2022-05-25" version="1">FVILSLHNCIVISFVLFLFGGNNSIQTFYFPQNYIDRFFLISFPTFTSVGALIVLVLCSAFLLLWQGERVNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R9G3</accession>
    <name>A0A8I5R9G3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="4">3.4.24.71</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.</text>
            <dbReference type="EC" id="3.4.24.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031518387.1">
        <property type="nucleotide sequence ID" value="XM_031662527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R9G3"/>
    <dbReference type="Ensembl" id="ENSPANT00000064666.1">
        <property type="protein sequence ID" value="ENSPANP00000059157.1"/>
        <property type="gene ID" value="ENSPANG00000038754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116273462"/>
    <dbReference type="KEGG" id="panu:116273462"/>
    <dbReference type="GeneTree" id="ENSGT00940000156050"/>
    <dbReference type="OMA" id="IAFGQTH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF130">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="12">
        <location>
            <begin position="85"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="289" mass="32028" checksum="DB38176DA4852292" modified="2022-05-25" version="1">MITQLHSSLGDRIRPCLKTNSPSVDVLVLVCTWAWGQGESAFLMPLIPIPKQCSTQAVPTCLPPCAEASHVCVACRWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFHCSPGSPMNPPHKCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A9CB57</accession>
    <name>A9CB57_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">transketolase</fullName>
            <ecNumber evidence="9">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">TKTL1</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="9"/>
    <dbReference type="EMBL" id="DP000488">
        <property type="protein sequence ID" value="ABX10984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162270.1">
        <property type="nucleotide sequence ID" value="NM_001168799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9CB57"/>
    <dbReference type="Ensembl" id="ENSPANT00000051868.2">
        <property type="protein sequence ID" value="ENSPANP00000036097.1"/>
        <property type="gene ID" value="ENSPANG00000011938.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137261"/>
    <dbReference type="KEGG" id="panu:100137261"/>
    <dbReference type="CTD" id="8277"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162426"/>
    <dbReference type="HOGENOM" id="CLU_009227_3_0_1"/>
    <dbReference type="OMA" id="EWTTGNL"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011938">
        <property type="expression patterns" value="Expressed in testis and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A9CB57">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000028">
        <property type="entry name" value="Transketolase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000033">
        <property type="entry name" value="Transketolase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000008">
        <property type="entry name" value="transketolase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF2">
        <property type="entry name" value="TRANSKETOLASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="289"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00002931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABX10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="596" mass="65312" checksum="179331B52DE71E87" modified="2008-01-15" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A9X195</accession>
    <name>A9X195_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Tropomodulin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">TMOD4</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-12" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000542">
        <property type="protein sequence ID" value="ABY40790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162418.1">
        <property type="nucleotide sequence ID" value="NM_001168947.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178987.1">
        <property type="nucleotide sequence ID" value="XM_009180723.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178996.1">
        <property type="nucleotide sequence ID" value="XM_009180732.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9X195"/>
    <dbReference type="SMR" id="A9X195"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004792"/>
    <dbReference type="Ensembl" id="ENSPANT00000005086.3">
        <property type="protein sequence ID" value="ENSPANP00000004792.1"/>
        <property type="gene ID" value="ENSPANG00000000635.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137413"/>
    <dbReference type="KEGG" id="panu:100137413"/>
    <dbReference type="CTD" id="29765"/>
    <dbReference type="eggNOG" id="KOG3735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158734"/>
    <dbReference type="HOGENOM" id="CLU_031052_0_1_1"/>
    <dbReference type="OMA" id="SDAEMCD"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000635">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005865">
        <property type="term" value="C:striated muscle thin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000006">
        <property type="entry name" value="Tropomodulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF9">
        <property type="entry name" value="TROPOMODULIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABY40790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="345" mass="39335" checksum="3ACE2692EF52E2CB" modified="2008-02-05" version="1">MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDREALLQYLEQQALEVKERDDLVPFTGEKKGKPYIQPKREIPAEEQITLEPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQT1</accession>
    <name>A0A096MQT1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Matrix metalloproteinase-23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">MMP23B</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="21">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891028.2">
        <property type="nucleotide sequence ID" value="XM_003890979.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQT1"/>
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    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 21" id="KW-0862">Zinc</keyword>
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        <location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="390" mass="43930" checksum="21CD3F8EFC98299D" modified="2018-02-28" version="2">MGRGARVPSEAPGAGVERRWLGAALVALCLLPVLVLLARLGAPAVPAWSAAQGDAAALGLSGVPPTRVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGHKILHKKGKVYWYKDQEPLEFSYPGYLALGEAHLSIIANAVNEGTYTCVVRRQQRVLTTYSWRVRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MR19</accession>
    <name>A0A096MR19_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC71</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003894493.1">
        <property type="nucleotide sequence ID" value="XM_003894444.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MR19"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002213"/>
    <dbReference type="Ensembl" id="ENSPANT00000000263.3">
        <property type="protein sequence ID" value="ENSPANP00000002213.3"/>
        <property type="gene ID" value="ENSPANG00000006140.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000451"/>
    <dbReference type="KEGG" id="panu:101000451"/>
    <dbReference type="CTD" id="64925"/>
    <dbReference type="eggNOG" id="ENOG502RY9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155306"/>
    <dbReference type="HOGENOM" id="CLU_049410_1_0_1"/>
    <dbReference type="OMA" id="CPETVGQ"/>
    <dbReference type="OrthoDB" id="8522252at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006140">
        <property type="expression patterns" value="Expressed in pineal body and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026695">
        <property type="entry name" value="Ccdc71/71L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14484">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14484:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15374">
        <property type="entry name" value="CCDC71L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002213.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="478" mass="50902" checksum="EA093E046151C3C8" modified="2022-05-25" version="3">MSVVVQHVEEKAVHSWSRISTAGKKALEEALLVFNPMSQDLSATEAQLVAFLQGLRDDGFQPTILRSGDVYGYSSCTANPPSQTKLQARAPNPTATSPPASAPRTAMRLPAGRATLLPMPLSGRLAKASTPALAKHATTNLLLSSLKQSSASHARGAAVGFPTHLYPGVYPAMRLSVVLEALVPLKTTMPCLGAKHKAQSLHLSLADSPLKLRKSSGKGPGNPRPKAPRKTTSKGSKCLTRKGPGAGPRRGSGHQSKTNRATGSPSVRRMKGGSALGTKAAQAKVAQTLAKAARSQARVARTQSKAAKARAKAKAARAKAKAARAKAKAKAKAKAKAARVKAKAKVMAARAKAKTKAKAVRAKAKVARTQPRGRGRPKGSAKTRTTRKVQKYRPETVGQKRKRAEEAKDLPPKKRTRLGPRSPKAWLGPGTAKLLKFRAIKVDRRSSDDEVRQRAQRILRVNLSPEIRLQPLLPHSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRL1</accession>
    <name>A0A096MRL1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulator of G-protein signaling 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RGS4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009190961.1">
        <property type="nucleotide sequence ID" value="XM_009192697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRL1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002413"/>
    <dbReference type="Ensembl" id="ENSPANT00000014576.3">
        <property type="protein sequence ID" value="ENSPANP00000002413.1"/>
        <property type="gene ID" value="ENSPANG00000015543.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008445"/>
    <dbReference type="KEGG" id="panu:101008445"/>
    <dbReference type="CTD" id="5999"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159036"/>
    <dbReference type="HOGENOM" id="CLU_059863_3_0_1"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015543">
        <property type="expression patterns" value="Expressed in frontal cortex and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRL1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08714">
        <property type="entry name" value="RGS_RGS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.196.10:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034953">
        <property type="entry name" value="RGS_RGS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF184">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="7">
        <location>
            <begin position="159"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="302" mass="33981" checksum="B6156C51F9C2D363" modified="2014-11-26" version="1">MYHMMLLIQKRKGTGSQLLRAGEAEGDRGAGTAELSSDWLDRRSWAIKETPTGLGGRRSEDSDNIFTGEEAKYAQSRSHSSSCRISFLLANPKLLNKMCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLQPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRX4</accession>
    <name>A0A096MRX4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ragulator complex protein LAMTOR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LAMTOR3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Interacts with MAP2K1/MEK1 and MAPK2. Interacts with MORG1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAMTOR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899058.1">
        <property type="nucleotide sequence ID" value="XM_003899009.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRX4"/>
    <dbReference type="SMR" id="A0A096MRX4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002533"/>
    <dbReference type="Ensembl" id="ENSPANT00000021632.3">
        <property type="protein sequence ID" value="ENSPANP00000002533.2"/>
        <property type="gene ID" value="ENSPANG00000009681.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020686"/>
    <dbReference type="KEGG" id="panu:101020686"/>
    <dbReference type="CTD" id="8649"/>
    <dbReference type="eggNOG" id="ENOG502RYGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013159"/>
    <dbReference type="HOGENOM" id="CLU_134641_0_0_1"/>
    <dbReference type="OMA" id="YQVIQMN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009681">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019209">
        <property type="term" value="F:kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902414">
        <property type="term" value="P:protein localization to cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000003">
        <property type="entry name" value="ragulator complex protein LAMTOR3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378">
        <property type="entry name" value="REGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002533.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="124" mass="13623" checksum="0A5196CF41D83D13" modified="2018-02-28" version="2">MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTI6</accession>
    <name>A0A096MTI6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat domain 64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WDR64</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017808856.1">
        <property type="nucleotide sequence ID" value="XM_017953367.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTI6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003120"/>
    <dbReference type="Ensembl" id="ENSPANT00000002195.3">
        <property type="protein sequence ID" value="ENSPANP00000003120.2"/>
        <property type="gene ID" value="ENSPANG00000021032.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001705"/>
    <dbReference type="CTD" id="128025"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160037"/>
    <dbReference type="HOGENOM" id="CLU_011653_2_0_1"/>
    <dbReference type="OMA" id="VIDTWPL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021032">
        <property type="expression patterns" value="Expressed in testis and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="863"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003120.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1081" mass="123361" checksum="879191642F69A082" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTQ6</accession>
    <name>A0A096MTQ6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM70</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial precursor proteins import receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Translocase of outer membrane 70 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Translocase of outer mitochondrial membrane protein 70</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Tom70 family.</text>
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        <property type="nucleotide sequence ID" value="XM_003893859.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTQ6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003197"/>
    <dbReference type="Ensembl" id="ENSPANT00000017267.3">
        <property type="protein sequence ID" value="ENSPANP00000003197.2"/>
        <property type="gene ID" value="ENSPANG00000025904.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998106"/>
    <dbReference type="KEGG" id="panu:100998106"/>
    <dbReference type="CTD" id="9868"/>
    <dbReference type="eggNOG" id="KOG0547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157095"/>
    <dbReference type="HOGENOM" id="CLU_017516_2_0_1"/>
    <dbReference type="OMA" id="DDITACC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025904">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTQ6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial import receptor subunit TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative mitochondrial import receptor subunit TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
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    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 19" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="114"/>
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        </location>
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    <feature type="repeat" description="TPR" evidence="19">
        <location>
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        <location>
            <begin position="401"/>
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    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="476"/>
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    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="545"/>
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        <location>
            <begin position="62"/>
            <end position="107"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075568"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079886"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003197.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="603" mass="67003" checksum="6CA5F8167A6EE034" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MU02</accession>
    <name>A0A096MU02_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">POC1 centriolar protein homolog B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">WD repeat-containing protein 51B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">POC1B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Acts as a positive regulator of centriole elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with POC1A. Interacts with FAM161A. Interacts with CEP44; the interaction is direct and recruits POC1B to centriolar microtubules. Forms a microtubule-associated complex with POC5, CETN2 and FAM161A. Interacts with CCDC15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat POC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906985.2">
        <property type="nucleotide sequence ID" value="XM_003906936.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MU02"/>
    <dbReference type="Ensembl" id="ENSPANT00000027997.3">
        <property type="protein sequence ID" value="ENSPANP00000003295.2"/>
        <property type="gene ID" value="ENSPANG00000015875.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013256"/>
    <dbReference type="KEGG" id="panu:101013256"/>
    <dbReference type="CTD" id="282809"/>
    <dbReference type="eggNOG" id="ENOG502QSVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160413"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_17_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015875">
        <property type="expression patterns" value="Expressed in pyloric antrum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MU02">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000235">
        <property type="entry name" value="POC1 centriolar protein homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000279">
        <property type="entry name" value="POC1 centriolar protein homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000528">
        <property type="entry name" value="POC1 centriolar protein homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF1">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003295.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="478" mass="53659" checksum="01FFE5EE1E08112D" modified="2022-05-25" version="2">MASATEDPVLERYFKGHKAAITSLDFSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELPYKGLNKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPPVVDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLLSPECSPTTTKKKTEDMSDLPCESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MV49</accession>
    <name>A0A096MV49_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adaptor related protein complex 5 subunit zeta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AP5Z1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003895726.2">
        <property type="nucleotide sequence ID" value="XM_003895677.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MV49"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003724"/>
    <dbReference type="Ensembl" id="ENSPANT00000008507.3">
        <property type="protein sequence ID" value="ENSPANP00000003724.2"/>
        <property type="gene ID" value="ENSPANG00000000258.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018766"/>
    <dbReference type="KEGG" id="panu:101018766"/>
    <dbReference type="CTD" id="9907"/>
    <dbReference type="eggNOG" id="ENOG502QVBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017592"/>
    <dbReference type="HOGENOM" id="CLU_019553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000258">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044599">
        <property type="term" value="C:AP-5 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028222">
        <property type="entry name" value="AP5Z1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055450">
        <property type="entry name" value="AP5Z1_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056856">
        <property type="entry name" value="TPR_AP5Z1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056857">
        <property type="entry name" value="TPR_AP5Z1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14764">
        <property type="entry name" value="SPG48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25153">
        <property type="entry name" value="TPR_AP5Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25154">
        <property type="entry name" value="TPR_AP5Z1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP-5 complex subunit zeta-1 N-terminal TPR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 ARM repeats" evidence="1">
        <location>
            <begin position="321"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 C-terminal TPR" evidence="3">
        <location>
            <begin position="450"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003724.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="808" mass="89018" checksum="802C6EEBD96BDF19" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MW61</accession>
    <name>A0A096MW61_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Centrosomal protein of 41 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Testis-specific gene A14 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CEP41</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Found in a complex with TTLL6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202128.2">
        <property type="nucleotide sequence ID" value="XM_009203864.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MW61"/>
    <dbReference type="Ensembl" id="ENSPANT00000025214.3">
        <property type="protein sequence ID" value="ENSPANP00000004102.3"/>
        <property type="gene ID" value="ENSPANG00000014228.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101009496"/>
    <dbReference type="CTD" id="95681"/>
    <dbReference type="GeneTree" id="ENSGT00390000002222"/>
    <dbReference type="HOGENOM" id="CLU_064316_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014228">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MW61">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000012">
        <property type="entry name" value="Centrosomal protein of 41 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004102.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="373" mass="41369" checksum="5A3CD2F5EAE9339E" modified="2022-05-25" version="3">MSLRRHIGNPEYLMKRIPQNPRYQHVKSRLDTGNSMTKYTEKLEEIKKNYRYKKDELFKRLKVTTFAQLIIQVASLSDQTLEVTAEEIQRLEDNDSAASDPDAETTARTNGKGNPGEQSPSPEQLINNAGAGDSSRSTLQSVISGVGELDLDKGPVKKAEPNTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPASCQQALPPGSARKRSSPKVPPLPAENKWRFTPEDLKKIEYYLEEEQGPADHPSRLNQANSSGRDSKVPGARSTQNLPAGGPASHSNPRSLSSGHLQGKPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWB9</accession>
    <name>A0A096MWB9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syncoilin, intermediate filament protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SYNC</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003891570.1">
        <property type="nucleotide sequence ID" value="XM_003891521.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWB9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004175"/>
    <dbReference type="Ensembl" id="ENSPANT00000009878.3">
        <property type="protein sequence ID" value="ENSPANP00000004175.1"/>
        <property type="gene ID" value="ENSPANG00000024949.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012298"/>
    <dbReference type="KEGG" id="panu:101012298"/>
    <dbReference type="CTD" id="81493"/>
    <dbReference type="eggNOG" id="ENOG502RKZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018108"/>
    <dbReference type="HOGENOM" id="CLU_562526_0_0_1"/>
    <dbReference type="OMA" id="GGMETKS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024949">
        <property type="expression patterns" value="Expressed in aorta and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWB9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030018">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045103">
        <property type="term" value="P:intermediate filament-based process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027702">
        <property type="entry name" value="Syncoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47147">
        <property type="entry name" value="SYNCOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47147:SF1">
        <property type="entry name" value="SYNCOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="168"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="354"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="481" mass="55246" checksum="01F0A02E50DFDB1B" modified="2014-11-26" version="1">MASREPRRGGDGAAQAARKTRAEANYPLPENSDSLNEAEALNPEVTLSSEGYLNLEDILYLEDTGDLDETLYVQETEKPEEALYIEEAMQPDEALHGEEPGNPEETVSVEETMEPDWMQFVEGPVEPGKPTNPEQVVHEGDTVTRAEKSNPEESLRAEPSPSMEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEDLAQLRDAYQKQKEQLRQQLEAPPSQRDGRFLQESRRLSAQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQKTQAEIQEMKEALRPLQAEARQLHLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMEQLRLSLAEELSTYKAMLPKSLEQADAPTSQAGGMETQSQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWH4</accession>
    <name>A0A096MWH4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division cycle associated 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CDCA2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003902604.2">
        <property type="nucleotide sequence ID" value="XM_003902555.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWH4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004230"/>
    <dbReference type="Ensembl" id="ENSPANT00000012535.4">
        <property type="protein sequence ID" value="ENSPANP00000004230.2"/>
        <property type="gene ID" value="ENSPANG00000008115.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101014073"/>
    <dbReference type="KEGG" id="panu:101014073"/>
    <dbReference type="CTD" id="157313"/>
    <dbReference type="eggNOG" id="ENOG502S079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154352"/>
    <dbReference type="HOGENOM" id="CLU_011968_0_0_1"/>
    <dbReference type="OMA" id="QKECDCS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008115">
        <property type="expression patterns" value="Expressed in testis and 29 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051983">
        <property type="term" value="P:regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029334">
        <property type="entry name" value="PP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21603">
        <property type="entry name" value="ANTIGEN KI-67-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21603:SF16">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15276">
        <property type="entry name" value="PP1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PP1-binding" evidence="8">
        <location>
            <begin position="389"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="804"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="930"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004230.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113151" checksum="3B64499F895BB3B7" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWH9</accession>
    <name>A0A096MWH9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 777</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF777</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202403.2">
        <property type="nucleotide sequence ID" value="XM_009204139.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202404.2">
        <property type="nucleotide sequence ID" value="XM_009204140.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017812803.2">
        <property type="nucleotide sequence ID" value="XM_017957314.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792073.2">
        <property type="nucleotide sequence ID" value="XM_021936381.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792074.2">
        <property type="nucleotide sequence ID" value="XM_021936382.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520902.1">
        <property type="nucleotide sequence ID" value="XM_031665042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWH9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004235"/>
    <dbReference type="Ensembl" id="ENSPANT00000002604.3">
        <property type="protein sequence ID" value="ENSPANP00000004235.3"/>
        <property type="gene ID" value="ENSPANG00000023421.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103883335"/>
    <dbReference type="KEGG" id="panu:103883335"/>
    <dbReference type="CTD" id="27153"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155153"/>
    <dbReference type="HOGENOM" id="CLU_002678_76_2_1"/>
    <dbReference type="OMA" id="ERGPAFN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023421">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051291">
        <property type="term" value="P:protein heterooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000320">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000410">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000617">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001210">
        <property type="entry name" value="zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001435">
        <property type="entry name" value="zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001701">
        <property type="entry name" value="zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF50">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF57.1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="488"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004235.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="831" mass="93824" checksum="2BFE61BD01B25A38" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWN7</accession>
    <name>A0A096MWN7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Epiphycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EPYC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031650658.1"/>
    </dbReference>
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    <dbReference type="STRING" id="9555.ENSPANP00000004295"/>
    <dbReference type="Ensembl" id="ENSPANT00000023255.3">
        <property type="protein sequence ID" value="ENSPANP00000004295.3"/>
        <property type="gene ID" value="ENSPANG00000012063.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019085"/>
    <dbReference type="KEGG" id="panu:101019085"/>
    <dbReference type="CTD" id="1833"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157574"/>
    <dbReference type="HOGENOM" id="CLU_067583_0_0_1"/>
    <dbReference type="OMA" id="EFYDIPL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012063">
        <property type="expression patterns" value="Expressed in putamen and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061975">
        <property type="term" value="P:articular cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000167">
        <property type="entry name" value="epiphycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043547">
        <property type="entry name" value="Mimecan/Epiphycan/Opticin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269:SF3">
        <property type="entry name" value="EPIPHYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269">
        <property type="entry name" value="EPIPHYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239846" evidence="11">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006912"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004295.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="322" mass="36722" checksum="2ACBD9DD9109738C" modified="2022-05-25" version="3">MKTLAILVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDQVEIEIATVMPSGNRELLTPPPQPEEAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MY04</accession>
    <name>A0A096MY04_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin-binding protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein unc-18 homolog 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein unc-18 homolog C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STXBP3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892357.2">
        <property type="nucleotide sequence ID" value="XM_003892308.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A096MY04"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004795"/>
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        <property type="protein sequence ID" value="ENSPANP00000004795.2"/>
        <property type="gene ID" value="ENSPANG00000022421.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_009210_2_0_1"/>
    <dbReference type="OMA" id="LSTCVRM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="Bgee" id="ENSPANG00000022421">
        <property type="expression patterns" value="Expressed in optic disc and 66 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042581">
        <property type="term" value="C:specific granule"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070820">
        <property type="term" value="C:tertiary granule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:syntaxin binding"/>
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        <property type="term" value="P:brain development"/>
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    <dbReference type="GO" id="GO:0043312">
        <property type="term" value="P:neutrophil degranulation"/>
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    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0022615">
        <property type="term" value="P:protein to membrane docking"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
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        <property type="entry name" value="Syntaxin binding protein 3"/>
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    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
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    <dbReference type="FunFam" id="1.25.40.60:FF:000004">
        <property type="entry name" value="syntaxin-binding protein 3 isoform X2"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
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        <property type="entry name" value="Sec-1-like_dom1"/>
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        <property type="entry name" value="Sec-1-like_dom3a"/>
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    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
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    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00082567"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="592" mass="67801" checksum="566268BB5585725A" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZ44</accession>
    <name>A0A096MZ44_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Kappa-casein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSN3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the kappa-casein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898856.1">
        <property type="nucleotide sequence ID" value="XM_003898807.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZ44"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005233"/>
    <dbReference type="Ensembl" id="ENSPANT00000005673.3">
        <property type="protein sequence ID" value="ENSPANP00000005233.1"/>
        <property type="gene ID" value="ENSPANG00000008668.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013437"/>
    <dbReference type="KEGG" id="panu:101013437"/>
    <dbReference type="CTD" id="1448"/>
    <dbReference type="eggNOG" id="ENOG502TM2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009184"/>
    <dbReference type="HOGENOM" id="CLU_103388_0_0_1"/>
    <dbReference type="OMA" id="YYVPNSY"/>
    <dbReference type="OrthoDB" id="9836334at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008668">
        <property type="expression patterns" value="Expressed in axillary lymph node and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007595">
        <property type="term" value="P:lactation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000117">
        <property type="entry name" value="Casein_kappa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11470">
        <property type="entry name" value="KAPPA CASEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11470:SF2">
        <property type="entry name" value="KAPPA-CASEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00997">
        <property type="entry name" value="Casein_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002374">
        <property type="entry name" value="Casein_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0494">Milk protein</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001927819" description="Kappa-casein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="182" mass="20466" checksum="5F0452C9A716070D" modified="2014-11-26" version="1">MKSFLLVVNVLALTLPFLAAEVQNQKQPACHENGERRFYQKTAPYVPMYYVPNSYPYYGTNLYQHRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLPNSHLPTVVRRPNLHPSFIAIPPKKLQDKIIIPTINTITTVEPTPAPTIEPTVDNVVTPEDFSESIITSTPETTTVSVTTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0Y1</accession>
    <name>A0A096N0Y1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-deoxynucleotidase HDDC2</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">HD domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HDDC2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="RefSeq" id="XP_003898279.1">
        <property type="nucleotide sequence ID" value="XM_003898230.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0Y1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005921"/>
    <dbReference type="Ensembl" id="ENSPANT00000008980.3">
        <property type="protein sequence ID" value="ENSPANP00000005921.1"/>
        <property type="gene ID" value="ENSPANG00000016874.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024416"/>
    <dbReference type="KEGG" id="panu:101024416"/>
    <dbReference type="CTD" id="51020"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009937"/>
    <dbReference type="HOGENOM" id="CLU_039453_2_2_1"/>
    <dbReference type="OMA" id="TWRLCLM"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016874">
        <property type="expression patterns" value="Expressed in pons and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0Y1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="14">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00015933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="204" mass="23344" checksum="2684FB56DB8FC337" modified="2014-11-26" version="1">MASVSSATFLGHGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVIKDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLEHKPGSLQDFYDSTAGKFNHPEIVQLVSELEAERNANIAAAASEPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1R6</accession>
    <name>A0A096N1R6_PAPAN</name>
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        <recommendedName>
            <fullName evidence="12">Nexilin</fullName>
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            <fullName evidence="13">F-actin-binding protein</fullName>
        </alternativeName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="11">Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.</text>
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    <comment type="subunit">
        <text evidence="4">Interacts with F-actin.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031662160.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A096N1R6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006248"/>
    <dbReference type="Ensembl" id="ENSPANT00000010541.3">
        <property type="protein sequence ID" value="ENSPANP00000006248.3"/>
        <property type="gene ID" value="ENSPANG00000016164.4"/>
    </dbReference>
    <dbReference type="GeneID" id="116268552"/>
    <dbReference type="eggNOG" id="ENOG502QU7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111176"/>
    <dbReference type="HOGENOM" id="CLU_023108_1_1_1"/>
    <dbReference type="OMA" id="NWTDKIE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016164">
        <property type="expression patterns" value="Expressed in heart and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1R6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="nexilin isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MITOGUARDIN 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="582"/>
            <end position="670"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="487"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="551"/>
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    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="376"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
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            <begin position="27"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="249"/>
            <end position="289"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="675" mass="80623" checksum="F151B140B495071C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2N0</accession>
    <name>A0A096N2N0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dpy-19 like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DPY19L4</name>
    </gene>
    <organism evidence="10 11">
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        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009211613.3">
        <property type="nucleotide sequence ID" value="XM_009213349.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N2N0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006574"/>
    <dbReference type="Ensembl" id="ENSPANT00000002748.3">
        <property type="protein sequence ID" value="ENSPANP00000006574.3"/>
        <property type="gene ID" value="ENSPANG00000007133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023892"/>
    <dbReference type="KEGG" id="panu:101023892"/>
    <dbReference type="CTD" id="286148"/>
    <dbReference type="eggNOG" id="KOG4587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="HOGENOM" id="CLU_014404_1_0_1"/>
    <dbReference type="OMA" id="PKYILFQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="Bgee" id="ENSPANG00000007133">
        <property type="expression patterns" value="Expressed in testis and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N2N0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20180">
        <property type="entry name" value="Dpy19L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047464">
        <property type="entry name" value="Dpy19L4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF2">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006574.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="864" mass="97833" checksum="3E065AB15EB77D75" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2Q7</accession>
    <name>A0A096N2Q7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC22A31</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N2Q7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006601"/>
    <dbReference type="Ensembl" id="ENSPANT00000020213.3">
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        <property type="gene ID" value="ENSPANG00000008152.3"/>
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    <dbReference type="OMA" id="SYWSCAS"/>
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        <property type="component" value="Chromosome 18"/>
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    <dbReference type="Bgee" id="ENSPANG00000008152">
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="48"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="292"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006601.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="35974" checksum="3C62A4926613277C" modified="2022-05-25" version="3">VGAGLFSVAGTLLLPGLAALVQDWHLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWHFAEASGVDPEDSSLEESSLVTELAMLSAGSPQPQYQSPLGLLRTQVTWRNGLILGFSSLVGEGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADRCGRRPVLLLGTMATGLASLLLLAGAQYLPGWTMLSLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAADPLDALHGRRGFFLQHVVFASLAVLALLCVLLLPESRGRGLPQSLQDADRLRRSPLLRGCPRQDHLPLLSPSDSCWVGHTPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2R1</accession>
    <name>A0A096N2R1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-Maf inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CMIP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A096N2R1"/>
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        <property type="protein sequence ID" value="ENSPANP00000006605.3"/>
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    <dbReference type="PANTHER" id="PTHR25480:SF0">
        <property type="entry name" value="C-MAF-INDUCING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR25480">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73"/>
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        <property type="entry name" value="PH domain-like"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="786" mass="87322" checksum="645A59DF7A84D3A2" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N3I7</accession>
    <name>A0A096N3I7_PAPAN</name>
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        <recommendedName>
            <fullName evidence="14">PR domain zinc finger protein 14</fullName>
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            <fullName evidence="15">PR domain-containing protein 14</fullName>
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        <name type="scientific">Papio anubis</name>
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    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
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                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
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                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Patil S.P."/>
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                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="13">Interacts with CBFA2T2.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060818">
        <property type="term" value="P:inactivation of paternal X chromosome by genomic imprinting"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001827">
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0040037">
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="zf-C2H2"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
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    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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        <property type="entry name" value="SET domain"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="251"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="400"/>
            <end position="431"/>
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    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="432"/>
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    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="461"/>
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    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="489"/>
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    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="517"/>
            <end position="545"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="546"/>
            <end position="571"/>
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    </feature>
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        <location>
            <begin position="131"/>
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    </feature>
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            <begin position="165"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065199"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073657"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006901.2"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="571" mass="64046" checksum="1E747BCB41119DFB" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N3L6</accession>
    <name>A0A096N3L6_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC191</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_017955165.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A096N3L6"/>
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        <property type="protein sequence ID" value="ENSPANP00000006933.3"/>
        <property type="gene ID" value="ENSPANG00000009818.3"/>
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    <dbReference type="eggNOG" id="ENOG502QS57">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154110"/>
    <dbReference type="HOGENOM" id="CLU_015375_0_0_1"/>
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    <dbReference type="OrthoDB" id="6256972at2759"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Bgee" id="ENSPANG00000009818">
        <property type="expression patterns" value="Expressed in optic disc and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="712"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006933.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="960" mass="113354" checksum="8238CEA116AB8F3F" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7W4</accession>
    <name>A0A096N7W4_PAPAN</name>
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            <fullName evidence="12">Tryptophan--tRNA ligase, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="13">(Mt)TrpRS</fullName>
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        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">WARS2</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096N7W4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008680"/>
    <dbReference type="Ensembl" id="ENSPANT00000013899.3">
        <property type="protein sequence ID" value="ENSPANP00000008680.3"/>
        <property type="gene ID" value="ENSPANG00000011381.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153724"/>
    <dbReference type="HOGENOM" id="CLU_029244_1_5_1"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011381">
        <property type="expression patterns" value="Expressed in metanephros cortex and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008680.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="362" mass="40307" checksum="D0DD0B50DEF0CE62" modified="2022-05-25" version="3">MALHSMRKARGCWRFIRALHKGSAAAPAPQKDSKKRIFSGIQPTGILHLGNYLGAIENWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTGGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAEGFNKKYGEFFPVPKSILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNMVAVHAAVTGLSVEEVVRRSAGMDTAHYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYPVCQEVKKLEILKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAP9</accession>
    <name>A0A096NAP9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase XIAP</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Baculoviral IAP repeat-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Inhibitor of apoptosis protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">RING-type E3 ubiquitin transferase XIAP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">X-linked inhibitor of apoptosis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">XIAP</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003918290.1">
        <property type="nucleotide sequence ID" value="XM_003918241.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809843.1">
        <property type="nucleotide sequence ID" value="XM_017954354.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788338.1">
        <property type="nucleotide sequence ID" value="XM_021932646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NAP9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000032267"/>
    <dbReference type="Ensembl" id="ENSPANT00000003436.3">
        <property type="protein sequence ID" value="ENSPANP00000009792.1"/>
        <property type="gene ID" value="ENSPANG00000019077.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022825"/>
    <dbReference type="KEGG" id="panu:101022825"/>
    <dbReference type="CTD" id="331"/>
    <dbReference type="eggNOG" id="KOG1101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158743"/>
    <dbReference type="HOGENOM" id="CLU_016347_1_1_1"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019077">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NAP9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010804">
        <property type="term" value="P:negative regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16714">
        <property type="entry name" value="RING-HC_BIRC4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14395">
        <property type="entry name" value="UBA_BIRC4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000050">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000065">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000008">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase xiap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048875">
        <property type="entry name" value="BIRC2-3-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042579">
        <property type="entry name" value="XIAP/BIRC8_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF115">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21290">
        <property type="entry name" value="UBA_BIRC2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00044244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00077586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="497" mass="56659" checksum="947D9B822D611334" modified="2014-11-26" version="1">MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFADFPSSSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFENSATQSTNSGIQNGQHKVENYLGSRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIITFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSTQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NBA3</accession>
    <name>A0A096NBA3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPP1R26</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSPANP00000010029.3"/>
        <property type="gene ID" value="ENSPANG00000024856.3"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="F:protein phosphatase inhibitor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PPP1R26"/>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 26"/>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 26"/>
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            <begin position="1"/>
            <end position="852"/>
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            <begin position="57"/>
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            <begin position="144"/>
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            <begin position="492"/>
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            <begin position="546"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="727"/>
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        <location>
            <begin position="848"/>
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            <begin position="1051"/>
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            <begin position="1122"/>
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            <begin position="1179"/>
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            <begin position="63"/>
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            <begin position="197"/>
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            <begin position="294"/>
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        <location>
            <begin position="436"/>
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        <location>
            <begin position="603"/>
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        <location>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="1210" mass="127356" checksum="DBCF74537EBB4CA5" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NBC9</accession>
    <name>A0A096NBC9_PAPAN</name>
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        <submittedName>
            <fullName evidence="11">Kelch like family member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KLHL13</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.</text>
    </comment>
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        <property type="gene ID" value="ENSPANG00000006811.4"/>
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    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154359"/>
    <dbReference type="HOGENOM" id="CLU_004253_14_3_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
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        <property type="expression patterns" value="Expressed in putamen and 65 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of cytokinesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Kelch-type beta propeller"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <property type="entry name" value="BACK"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="PANTHER" id="PTHR45632:SF7">
        <property type="entry name" value="KELCH-LIKE PROTEIN 13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LD33804P"/>
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        <property type="entry name" value="Kelch"/>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="95"/>
            <end position="164"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010064.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="658" mass="74630" checksum="F0CA2A42E52E6306" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCH5</accession>
    <name>A0A096NCH5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8</fullName>
            <ecNumber evidence="5">2.1.1.229</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Alkylated DNA repair protein alkB homolog 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Alpha-ketoglutarate-dependent dioxygenase ALKBH8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ALKBH8</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10408"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74851"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.1.1.229"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with TRMT112.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.229" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003910686.3">
        <property type="nucleotide sequence ID" value="XM_003910637.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009185463.3">
        <property type="nucleotide sequence ID" value="XM_009187199.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009185464.3">
        <property type="nucleotide sequence ID" value="XM_009187200.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NCH5"/>
    <dbReference type="Ensembl" id="ENSPANT00000007712.4">
        <property type="protein sequence ID" value="ENSPANP00000010522.3"/>
        <property type="gene ID" value="ENSPANG00000010011.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101015427"/>
    <dbReference type="KEGG" id="panu:101015427"/>
    <dbReference type="CTD" id="91801"/>
    <dbReference type="GeneTree" id="ENSGT00940000158563"/>
    <dbReference type="OMA" id="KYLGCNP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010011">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NCH5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12431">
        <property type="entry name" value="RRM_ALKBH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000012">
        <property type="entry name" value="AlkB homolog 8, tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1520:FF:000001">
        <property type="entry name" value="Alkylated DNA repair protein alkB homolog 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000313">
        <property type="entry name" value="Alkylated DNA repair protein alkB homolog 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015095">
        <property type="entry name" value="AlkB_hom8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034256">
        <property type="entry name" value="ALKBH8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09004">
        <property type="entry name" value="ALKBH8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="24">
        <location>
            <begin position="220"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="517"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010522.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="664" mass="75113" checksum="427AEF833E82DD71" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCP4</accession>
    <name>A0A096NCP4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apolipoprotein C-III</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Apolipoprotein C3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">APOC3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein C3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NCP4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010600"/>
    <dbReference type="Ensembl" id="ENSPANT00000010470.3">
        <property type="protein sequence ID" value="ENSPANP00000010600.2"/>
        <property type="gene ID" value="ENSPANG00000008369.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SZ00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015395"/>
    <dbReference type="HOGENOM" id="CLU_154694_0_0_1"/>
    <dbReference type="OMA" id="YWSTFKG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008369">
        <property type="expression patterns" value="Expressed in liver and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042627">
        <property type="term" value="C:chylomicron"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034363">
        <property type="term" value="C:intermediate-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034366">
        <property type="term" value="C:spherical high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070653">
        <property type="term" value="F:high-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055102">
        <property type="term" value="F:lipase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034382">
        <property type="term" value="P:chylomicron remnant clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034375">
        <property type="term" value="P:high-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060621">
        <property type="term" value="P:negative regulation of cholesterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010987">
        <property type="term" value="P:negative regulation of high-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010989">
        <property type="term" value="P:negative regulation of low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048261">
        <property type="term" value="P:negative regulation of receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010897">
        <property type="term" value="P:negative regulation of triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010916">
        <property type="term" value="P:negative regulation of very-low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010903">
        <property type="term" value="P:negative regulation of very-low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032489">
        <property type="term" value="P:regulation of Cdc42 protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.90.10">
        <property type="entry name" value="Apolipoprotein CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008403">
        <property type="entry name" value="Apo-CIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038195">
        <property type="entry name" value="Apo_CIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14225">
        <property type="entry name" value="APOLIPOPROTEIN C-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14225:SF0">
        <property type="entry name" value="APOLIPOPROTEIN C-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05778">
        <property type="entry name" value="Apo-CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0162">Chylomicron</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0850">VLDL</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014130072" description="Apolipoprotein C-III" evidence="14">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010600.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="117" mass="12653" checksum="5E52C548705EF683" modified="2018-02-28" version="2">MGAWGAPHRTIPCRNRGAMQPRVLLVAALLSLLASARASEAEDTSLLGFMQGYMQHATKTAKDALTSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKLSGFWDLNPEATPTLAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDQ9</accession>
    <name>A0A096NDQ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable ATP-dependent RNA helicase DDX41</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAD box protein 41</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DDX41</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Identified in the spliceosome C complex. Interacts with ERCC6. Interacts with FAM50A. Interacts with STING1. Interacts with CGAS. Interacts with several spliceosomes components such as PRP19 or CDC5L.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_003900647.1">
        <property type="nucleotide sequence ID" value="XM_003900598.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDQ9"/>
    <dbReference type="Ensembl" id="ENSPANT00000009516.4">
        <property type="protein sequence ID" value="ENSPANP00000011006.3"/>
        <property type="gene ID" value="ENSPANG00000012013.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101002008"/>
    <dbReference type="KEGG" id="panu:101002008"/>
    <dbReference type="CTD" id="51428"/>
    <dbReference type="GeneTree" id="ENSGT00940000156333"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_5_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012013">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDQ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="212"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="407"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011006.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="622" mass="69866" checksum="E0A33F557E1ADEAA" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NF59</accession>
    <name>A0A096NF59_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WDR26</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Forms homooligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with DDB1-CUL4A/B E3 ligase complexes. Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2. Interacts with AXIN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NF59"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011552"/>
    <dbReference type="Ensembl" id="ENSPANT00000004242.3">
        <property type="protein sequence ID" value="ENSPANP00000011552.3"/>
        <property type="gene ID" value="ENSPANG00000012516.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153634"/>
    <dbReference type="HOGENOM" id="CLU_616707_0_0_1"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012516">
        <property type="expression patterns" value="Expressed in esophagus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000087">
        <property type="entry name" value="WD repeat-containing protein 26 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="256"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="709"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011552.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="761" mass="81260" checksum="24DDE66925D99A52" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFW8</accession>
    <name>A0A096NFW8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Parathyroid hormone</fullName>
            <shortName evidence="10">PTH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTH</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with PTH1R (via N-terminal extracellular domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the parathyroid hormone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NFW8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011826"/>
    <dbReference type="Ensembl" id="ENSPANT00000008277.3">
        <property type="protein sequence ID" value="ENSPANP00000011826.2"/>
        <property type="gene ID" value="ENSPANG00000021901.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SB2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018603"/>
    <dbReference type="HOGENOM" id="CLU_164143_0_0_1"/>
    <dbReference type="OMA" id="MKLQDVH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021901">
        <property type="expression patterns" value="Expressed in thyroid gland and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051428">
        <property type="term" value="F:peptide hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031857">
        <property type="term" value="F:type 1 parathyroid hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071866">
        <property type="term" value="P:negative regulation of apoptotic process in bone marrow cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071864">
        <property type="term" value="P:positive regulation of cell proliferation in bone marrow"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045725">
        <property type="term" value="P:positive regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060732">
        <property type="term" value="P:positive regulation of inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090290">
        <property type="term" value="P:positive regulation of osteoclast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003625">
        <property type="entry name" value="PTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001415">
        <property type="entry name" value="PTH/PTH-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10541">
        <property type="entry name" value="PARATHYROID HORMONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10541:SF2">
        <property type="entry name" value="PARATHYROID HORMONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01279">
        <property type="entry name" value="Parathyroid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001832">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00087">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00335">
        <property type="entry name" value="PARATHYROID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 10" id="KW-0372">Hormone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013989174" description="Parathyroid hormone" evidence="10">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011826.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="115" mass="12890" checksum="8C2500EF24BE5597" modified="2018-02-28" version="2">MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFIALGAPLAPRDAGSQRPRKKEDNILVESHEKSLGEADKADVDVLTKAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NG20</accession>
    <name>A0A096NG20_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BAI1-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane-associated guanylate kinase inverted 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MAGI1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_017810799.2">
        <property type="nucleotide sequence ID" value="XM_017955310.2"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000011879"/>
    <dbReference type="Ensembl" id="ENSPANT00000008718.4">
        <property type="protein sequence ID" value="ENSPANP00000011879.3"/>
        <property type="gene ID" value="ENSPANG00000024536.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101024164"/>
    <dbReference type="CTD" id="9223"/>
    <dbReference type="eggNOG" id="KOG3209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155820"/>
    <dbReference type="HOGENOM" id="CLU_004562_1_0_1"/>
    <dbReference type="OMA" id="QYENPML"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024536">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NG20">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051393">
        <property type="term" value="F:alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022409">
        <property type="term" value="P:positive regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06730">
        <property type="entry name" value="PDZ0_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06731">
        <property type="entry name" value="PDZ1_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06732">
        <property type="entry name" value="PDZ2_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06733">
        <property type="entry name" value="PDZ3_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06734">
        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06735">
        <property type="entry name" value="PDZ5_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
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        <property type="entry name" value="membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2"/>
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        <property type="match status" value="6"/>
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    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF12">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16663">
        <property type="entry name" value="MAGI_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16666">
        <property type="entry name" value="MAGI_u5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
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        <property type="entry name" value="WW domain"/>
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        <property type="entry name" value="GUANYLATE_KINASE_1"/>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0796">Tight junction</keyword>
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        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="16">
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            <begin position="96"/>
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            <begin position="1121"/>
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            <begin position="236"/>
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            <begin position="718"/>
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            <begin position="902"/>
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            <begin position="1081"/>
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            <begin position="1203"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="402"/>
            <end position="419"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
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            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
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            <begin position="584"/>
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            <begin position="612"/>
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            <begin position="740"/>
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        <location>
            <begin position="754"/>
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        <location>
            <begin position="909"/>
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            <begin position="945"/>
            <end position="957"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="1081"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="1247"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="1323"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1372"/>
            <end position="1460"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00058771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00070829"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00078448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011879.3"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1460" mass="161378" checksum="634130B1505DDDE3" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGQ2</accession>
    <name>A0A096NGQ2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase NEURL3</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Lung-inducible neuralized-related C3CH4 RING domain protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Neuralized-like protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase NEURL3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NEURL3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
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        <property type="nucleotide sequence ID" value="XM_003908982.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A096NGQ2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012138"/>
    <dbReference type="Ensembl" id="ENSPANT00000019348.3">
        <property type="protein sequence ID" value="ENSPANP00000012138.1"/>
        <property type="gene ID" value="ENSPANG00000023239.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000319"/>
    <dbReference type="KEGG" id="panu:101000319"/>
    <dbReference type="CTD" id="93082"/>
    <dbReference type="eggNOG" id="KOG4625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162540"/>
    <dbReference type="HOGENOM" id="CLU_090535_0_0_1"/>
    <dbReference type="OMA" id="HTHFCSS"/>
    <dbReference type="OrthoDB" id="6078042at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023239">
        <property type="expression patterns" value="Expressed in descending colon and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NGQ2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901800">
        <property type="term" value="P:positive regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Neuralized E3 ubiquitin protein ligase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000527">
        <property type="entry name" value="Neuralized E3 ubiquitin protein ligase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
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    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEURL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="19">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="262" mass="28881" checksum="D6000662B032DC28" modified="2014-11-26" version="1">MGAQLCFEANAKAPREALRFHAETKGAQVRLDTRGCTAHRRATFHDGIVFSQRPVRLGERVVLRLLREESGWCGGLRVGFTRLDPACVSVPSLPPFVCPDLEEQSPTWAAVLPEGCALVGDVVRFWVDRRGRLFAKVNAGCRFLLREGVPVGAPLWAVMDVYGTTKTIELLDPTASRLPTAMPWDLRNKAVAEPKATPGEECAICFYHAANTCLVPCGHTYFCRCCAWRVFRDTAKCPVCRWQIEAVAPAQGPPALRTEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNP8</accession>
    <name>A0A096NNP8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heteroous nuclear ribonucleoprotein C</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM HNRPC family. RALY subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009209369.2">
        <property type="nucleotide sequence ID" value="XM_009211105.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209370.2">
        <property type="nucleotide sequence ID" value="XM_009211106.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209373.2">
        <property type="nucleotide sequence ID" value="XM_009211109.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209374.2">
        <property type="nucleotide sequence ID" value="XM_009211110.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209375.2">
        <property type="nucleotide sequence ID" value="XM_009211111.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796677.1">
        <property type="nucleotide sequence ID" value="XM_021940985.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796678.1">
        <property type="nucleotide sequence ID" value="XM_021940986.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNP8"/>
    <dbReference type="SMR" id="A0A096NNP8"/>
    <dbReference type="Ensembl" id="ENSPANT00000025454.3">
        <property type="protein sequence ID" value="ENSPANP00000014608.3"/>
        <property type="gene ID" value="ENSPANG00000020782.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023879"/>
    <dbReference type="CTD" id="3183"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153402"/>
    <dbReference type="HOGENOM" id="CLU_079090_0_0_1"/>
    <dbReference type="OMA" id="TMDWSSS"/>
    <dbReference type="OrthoDB" id="9538853at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020782">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NNP8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12603">
        <property type="entry name" value="RRM_hnRNPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000019">
        <property type="entry name" value="heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017347">
        <property type="entry name" value="hnRNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF3">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037992">
        <property type="entry name" value="hnRNP-C_Raly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014608.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="306" mass="33670" checksum="17BBC78690C69C5C" modified="2022-05-25" version="3">MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSKSGKLKGDDLQAIKKELTQIKQKVDSLLENLEKIEKEQSKQAVEMKNDKSEEEQSSSSVKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSANGEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNW2</accession>
    <name>A0A096NNW2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T cell receptor alpha variable 36/delta variable 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRAV36DV7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NNW2"/>
    <dbReference type="Ensembl" id="ENSPANT00000002209.3">
        <property type="protein sequence ID" value="ENSPANP00000014672.3"/>
        <property type="gene ID" value="ENSPANG00000026146.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3MM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160183"/>
    <dbReference type="HOGENOM" id="CLU_077975_8_3_1"/>
    <dbReference type="OMA" id="CSYEVTN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026146">
        <property type="expression patterns" value="Expressed in thymus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051006">
        <property type="entry name" value="TCR_variable_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343:SF13">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1279">T cell receptor</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035294932" evidence="8">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014672.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="134" mass="15028" checksum="B2987F9BE6C3F5F0" modified="2022-05-25" version="3">MMKRSQALLAIFWILLSWVSSEDKVMQNPLSLVVHEGDTVTLNCSYEVVNFQSLLWYKQEKKAPTFLFTLTSSGIEKKSGRLSSILDKKDFFSILNITATQTRDSAVYLCAVEAQCSLVTCSLYSNSTAEALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQU5</accession>
    <name>A0A096NQU5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 35 member D3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC35D3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003898172.1">
        <property type="nucleotide sequence ID" value="XM_003898123.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQU5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015409"/>
    <dbReference type="Ensembl" id="ENSPANT00000025658.3">
        <property type="protein sequence ID" value="ENSPANP00000015409.1"/>
        <property type="gene ID" value="ENSPANG00000005133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002219"/>
    <dbReference type="KEGG" id="panu:101002219"/>
    <dbReference type="CTD" id="340146"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160083"/>
    <dbReference type="HOGENOM" id="CLU_040726_3_0_1"/>
    <dbReference type="OMA" id="GWKDPTM"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005133">
        <property type="expression patterns" value="Expressed in putamen and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060155">
        <property type="term" value="P:platelet dense granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="416" mass="44210" checksum="282B43F55A7A3933" modified="2014-11-26" version="1">MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLVQCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLPMYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVTGVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFPGWKDPAMVCIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSDVEPTSLFIAGVVVNTLGSIIYCVAKFMETRKQSKYEDLEAQPRGEEAQLSGDQLPFVMEELPGEGGNGPSEGGEAADGPNQQSKQEVRGSPRGVPLVAGSSEEGSRRSLKDAYLEVWRLVRGTRYMKKDYLIENEELPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRA5</accession>
    <name>A0A096NRA5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein sel-1 homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Suppressor of lin-12-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEL1L</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902180.1">
        <property type="nucleotide sequence ID" value="XM_003902131.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NRA5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015575"/>
    <dbReference type="Ensembl" id="ENSPANT00000015868.3">
        <property type="protein sequence ID" value="ENSPANP00000015575.1"/>
        <property type="gene ID" value="ENSPANG00000020039.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021761"/>
    <dbReference type="KEGG" id="panu:101021761"/>
    <dbReference type="CTD" id="6400"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156671"/>
    <dbReference type="HOGENOM" id="CLU_007931_2_1_1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020039">
        <property type="expression patterns" value="Expressed in pancreas and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NRA5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000208">
        <property type="entry name" value="Protein sel-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000193">
        <property type="entry name" value="protein sel-1 homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000200">
        <property type="entry name" value="protein sel-1 homolog 1 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF70">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 18" id="KW-0732">Signal</keyword>
    <keyword evidence="2 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001929152" description="Protein sel-1 homolog 1" evidence="18">
        <location>
            <begin position="22"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="19">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="766"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="794" mass="88709" checksum="50C2BEED4B07DC60" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVT4</accession>
    <name>A0A096NVT4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905213.1">
        <property type="nucleotide sequence ID" value="XM_003905164.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NVT4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017159"/>
    <dbReference type="Ensembl" id="ENSPANT00000013662.3">
        <property type="protein sequence ID" value="ENSPANP00000017159.2"/>
        <property type="gene ID" value="ENSPANG00000021092.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021528"/>
    <dbReference type="KEGG" id="panu:101021528"/>
    <dbReference type="eggNOG" id="ENOG502SC50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163410"/>
    <dbReference type="HOGENOM" id="CLU_118168_0_1_1"/>
    <dbReference type="OMA" id="MWKVIVP"/>
    <dbReference type="OrthoDB" id="9529840at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021092">
        <property type="expression patterns" value="Expressed in esophagus and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001580">
        <property type="term" value="P:detection of chemical stimulus involved in sensory perception of bitter taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF3">
        <property type="entry name" value="CYSTATIN-S-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315317" description="Cystatin domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="4">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017159.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="141" mass="16342" checksum="AA9A5530E0DC68F1" modified="2022-05-25" version="2">MAQPLCTLLLLLAALARAQAWSPEEEDRVIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLRVLRAREQVVAGMNYFLDVELGRTTCTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVZ0</accession>
    <name>A0A096NVZ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein numb homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NUMB</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the process of neurogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009210171.1">
        <property type="nucleotide sequence ID" value="XM_009211907.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009210172.1">
        <property type="nucleotide sequence ID" value="XM_009211908.4"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PROTEIN NUMB HOMOLOG"/>
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        <property type="entry name" value="NumbF"/>
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        <property type="entry name" value="PID"/>
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    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZ73</accession>
    <name>A0A096NZ73_PAPAN</name>
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        <submittedName>
            <fullName evidence="5">Arkadia (RNF111) N-terminal like PKA signaling regulator 2N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARK2N</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NZ73"/>
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        <property type="gene ID" value="ENSPANG00000006488.3"/>
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    <dbReference type="eggNOG" id="ENOG502QUC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016167"/>
    <dbReference type="HOGENOM" id="CLU_056953_0_0_1"/>
    <dbReference type="OMA" id="PVIAHYD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006488">
        <property type="expression patterns" value="Expressed in esophagus and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZ73">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903901">
        <property type="term" value="P:negative regulation of viral life cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019046">
        <property type="term" value="P:release from viral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029306">
        <property type="entry name" value="RNF111_N"/>
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    <dbReference type="InterPro" id="IPR051073">
        <property type="entry name" value="ZNRF3_Arkadia_E3_ligases"/>
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    <dbReference type="PANTHER" id="PTHR16200">
        <property type="entry name" value="RING ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15303">
        <property type="entry name" value="RNF111_N"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="67"/>
            <end position="225"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
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            <begin position="1"/>
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        <location>
            <begin position="23"/>
            <end position="32"/>
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    </feature>
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        <location>
            <begin position="87"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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        <location>
            <begin position="203"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF15303"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018394.2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="404" mass="43450" checksum="2002CD8FAAF0711E" modified="2022-05-25" version="2">MKMEEAVGKVEELIESEAPPKASEQETAKEEDGSVELESQVQKDGVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRVYESDSSNHCMLSPSSSGHLADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSRSESETSTMAAKKNRQSSDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDSSTSDSDLTCDSSTSSSDDDEEVSGSSKTITAEIPDGPPVVAHYDMSDTNSEPEVVNVDNLLAAAVVQEHNNSVGGQDTGATWRTTGLLEELNAEAGHLDPGFLASDKTSAGNAPLNEEINIASSDSEVEIVGVQEHARCVHPRGGVIQSVSSWKHGSGTQYVSTRQTQSWTAVTPQQTWASPAEVVDLTLDEDSRRKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P192</accession>
    <name>A0A096P192_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 3, catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-glycan biosynthesis class O protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIGO</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P192"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019117"/>
    <dbReference type="Ensembl" id="ENSPANT00000026616.3">
        <property type="protein sequence ID" value="ENSPANP00000019117.2"/>
        <property type="gene ID" value="ENSPANG00000025326.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144278"/>
    <dbReference type="HOGENOM" id="CLU_004298_2_0_1"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025326">
        <property type="expression patterns" value="Expressed in cornea and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P192">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000041">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019117.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118662" checksum="4FC6121BCC4EB5DC" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2S8</accession>
    <name>A0A096P2S8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium voltage-gated channel subfamily A regulatory beta subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">KCNAB3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P2S8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019653"/>
    <dbReference type="Ensembl" id="ENSPANT00000023130.3">
        <property type="protein sequence ID" value="ENSPANP00000019653.2"/>
        <property type="gene ID" value="ENSPANG00000023939.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159306"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OMA" id="EQPAYNM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023939">
        <property type="expression patterns" value="Expressed in visual cortex and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19160">
        <property type="entry name" value="AKR_KCAB3B_AKR6A9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000001">
        <property type="entry name" value="voltage-gated potassium channel subunit beta-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005983">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005402">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01293">
        <property type="entry name" value="Kv_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF3">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01580">
        <property type="entry name" value="KCNAB3CHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="93"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019653.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="404" mass="43740" checksum="5FA9948727AE0497" modified="2018-02-28" version="2">MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPTGAGHGNPPGGGGSGPKARAALVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGSVTWYPLPCGLITSKYDGRVPDTCRASIKGYQWLKDKVQSEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIEHLGALQVLSQLTPQTVMEIDGLLGNKPHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3R9</accession>
    <name>A0A096P3R9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Rho GTPase-activating protein 21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Rho GTPase-activating protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Rho-type GTPase-activating protein 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ARHGAP21</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031508563.1">
        <property type="nucleotide sequence ID" value="XM_031652703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508564.1">
        <property type="nucleotide sequence ID" value="XM_031652704.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000019994"/>
    <dbReference type="Ensembl" id="ENSPANT00000021016.3">
        <property type="protein sequence ID" value="ENSPANP00000019994.3"/>
        <property type="gene ID" value="ENSPANG00000023086.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003298"/>
    <dbReference type="CTD" id="57584"/>
    <dbReference type="eggNOG" id="KOG4407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155406"/>
    <dbReference type="HOGENOM" id="CLU_001776_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023086">
        <property type="expression patterns" value="Expressed in optic disc and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P3R9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06756">
        <property type="entry name" value="PDZ_ARHGAP21_23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01253">
        <property type="entry name" value="PH_ARHGAP21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04395">
        <property type="entry name" value="RhoGAP_ARHGAP21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000014">
        <property type="entry name" value="Rho GTPase activating protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000101">
        <property type="entry name" value="Rho GTPase activating protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000066">
        <property type="entry name" value="Rho GTPase activating protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
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        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 21"/>
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        <property type="entry name" value="PH"/>
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        <property type="entry name" value="RhoGAP"/>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
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        <property type="entry name" value="PDZ domain-like"/>
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        <property type="entry name" value="PH domain-like"/>
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    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
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            <begin position="50"/>
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            <begin position="931"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4W4</accession>
    <name>A0A096P4W4_PAPAN</name>
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        <recommendedName>
            <fullName evidence="12">Neuropeptide FF receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">G-protein coupled receptor 147</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">RFamide-related peptide receptor OT7T022</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NPFFR1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="term" value="C:cilium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:neuropeptide receptor activity"/>
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        <property type="term" value="F:peptide binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to hormone stimulus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Neuropeptide FF receptor 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    <dbReference type="InterPro" id="IPR005395">
        <property type="entry name" value="NPFF_rcpt"/>
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    <dbReference type="InterPro" id="IPR005396">
        <property type="entry name" value="NPFF_rcpt_1"/>
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    <dbReference type="PANTHER" id="PTHR24241:SF4">
        <property type="entry name" value="NEUROPEPTIDE FF RECEPTOR 1"/>
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        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="PRINTS" id="PR01570">
        <property type="entry name" value="NPFFRECEPTOR"/>
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        <property type="entry name" value="NPFFRECEPTR1"/>
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    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="42"/>
            <end position="69"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="101"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="121"/>
            <end position="139"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="159"/>
            <end position="182"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="215"/>
            <end position="237"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="268"/>
            <end position="293"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="313"/>
            <end position="332"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="60"/>
            <end position="329"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="379"/>
            <end position="400"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="20"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025478"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074417"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00075893"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082066"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020389.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="430" mass="47736" checksum="101C6EA650BA092D" modified="2022-05-25" version="3">MEGEPSQPPNSSWPLSQNGTNAEATPAANLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVYPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRKVYTAVLFSHIYLAPLALIVVMYARIARKLCQAPGPARGGEEAADGRAARRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCQRPLGSHKGAYCEWPGGLLHRRVFVAVRPSDSGLPPESGPSSGAPRPGRLPLRNGRVAHHGLAREGPGCSHLPLTIPAWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5T9</accession>
    <name>A0A096P5T9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Reticulophagy regulator family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RETREG3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETREG family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003913084.4"/>
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        <property type="protein sequence ID" value="ENSPANP00000020714.1"/>
        <property type="gene ID" value="ENSPANG00000021419.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004415"/>
    <dbReference type="KEGG" id="panu:101004415"/>
    <dbReference type="CTD" id="162427"/>
    <dbReference type="eggNOG" id="ENOG502QPTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161349"/>
    <dbReference type="HOGENOM" id="CLU_036265_0_0_1"/>
    <dbReference type="OMA" id="HRVFQHV"/>
    <dbReference type="OrthoDB" id="10029527at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021419">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P5T9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RETR3_RHD"/>
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        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043384">
        <property type="entry name" value="RETREG1/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659:SF1">
        <property type="entry name" value="RETICULOPHAGY REGULATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="11">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="294"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="316"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="466" mass="51429" checksum="286516CD035E76FA" modified="2014-11-26" version="1">MAEAEGVAATPGPASGSTFRSRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYFMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQSMIQLALSGASQPGPSGAPAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUG8</accession>
    <name>A0A0A0MUG8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 7 member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC7A10</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003915341.1">
        <property type="nucleotide sequence ID" value="XM_003915292.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUG8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001470"/>
    <dbReference type="Ensembl" id="ENSPANT00000017447.3">
        <property type="protein sequence ID" value="ENSPANP00000001470.1"/>
        <property type="gene ID" value="ENSPANG00000005447.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010707"/>
    <dbReference type="KEGG" id="panu:101010707"/>
    <dbReference type="CTD" id="56301"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156469"/>
    <dbReference type="HOGENOM" id="CLU_007946_3_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005447">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042941">
        <property type="term" value="P:D-alanine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042942">
        <property type="term" value="P:D-serine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000008">
        <property type="entry name" value="large neutral amino acids transporter small subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF73">
        <property type="entry name" value="ASC-TYPE AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="195"/>
            <end position="214"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="336"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="357"/>
            <end position="381"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="387"/>
            <end position="410"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="444"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="469"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="500"/>
            <end position="523"/>
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    </feature>
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            <begin position="1"/>
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            <begin position="15"/>
            <end position="27"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="523" mass="56964" checksum="6B3D719219BE2DB4" modified="2015-01-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MV36</accession>
    <name>A0A0A0MV36_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3 13">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MAP3K10</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Homodimerization via the leucine zipper domains is required for autophosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
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    <dbReference type="EC" id="2.7.11.25" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_021786796.2">
        <property type="nucleotide sequence ID" value="XM_021931104.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A0A0MV36"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004938"/>
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        <property type="gene ID" value="ENSPANG00000016117.3"/>
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    <dbReference type="GeneID" id="101023378"/>
    <dbReference type="KEGG" id="panu:101023378"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160518"/>
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        <property type="component" value="Chromosome 20"/>
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    <dbReference type="Bgee" id="ENSPANG00000016117">
        <property type="expression patterns" value="Expressed in amygdala and 56 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005737">
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
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        <property type="project" value="RHEA"/>
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    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd12059">
        <property type="entry name" value="SH3_MLK1-3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.30.40:FF:000079">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
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    <dbReference type="FunFam" id="3.30.200.20:FF:000085">
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="MLK1-3_SH3"/>
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    <dbReference type="InterPro" id="IPR016231">
        <property type="entry name" value="MLK1-4"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    <dbReference type="PROSITE" id="PS00108">
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    <dbReference type="PROSITE" id="PS50002">
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    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 16" id="KW-0728">SH3 domain</keyword>
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        <location>
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    <feature type="domain" description="Protein kinase" evidence="21">
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="19">
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    <feature type="region of interest" description="Disordered" evidence="19">
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        <location>
            <begin position="391"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="501"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="566"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="611"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="631"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="773"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="911"/>
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    <feature type="active site" description="Proton acceptor" evidence="14">
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            <position position="222"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="15 17">
        <location>
            <position position="125"/>
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        <ligand>
            <name>ATP</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000556"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000556-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000556-2"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004938.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="952" mass="103386" checksum="F20C1383F5D0B224" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVD2</accession>
    <name>A0A0A0MVD2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TIMM50</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVD2"/>
    <dbReference type="Ensembl" id="ENSPANT00000001836.3">
        <property type="protein sequence ID" value="ENSPANP00000006057.1"/>
        <property type="gene ID" value="ENSPANG00000010724.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240503"/>
    <dbReference type="HOGENOM" id="CLU_048293_1_1_1"/>
    <dbReference type="OMA" id="WKSLHYY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010724">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MVD2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140608">
        <property type="term" value="F:cysteine-type endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005134">
        <property type="term" value="F:interleukin-2 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="16">
        <location>
            <begin position="143"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="353" mass="39599" checksum="035D8D0BDC9BE3FB" modified="2015-01-07" version="1">MAASAALFSRLRSGLRLGSRGLCTRLATPPPRAPDQAAEIGSRGGTKAQGPQQQPGSEGPSYAKKVALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLGSLTSRLWPRSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWG1</accession>
    <name>A0A0A0MWG1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SELENOV</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWG1"/>
    <dbReference type="Ensembl" id="ENSPANT00000011648.3">
        <property type="protein sequence ID" value="ENSPANP00000009454.3"/>
        <property type="gene ID" value="ENSPANG00000013634.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S9W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163358"/>
    <dbReference type="HOGENOM" id="CLU_073345_0_0_1"/>
    <dbReference type="OMA" id="YCGLXSY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013634">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MWG1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000220">
        <property type="entry name" value="Selenoprotein V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051441">
        <property type="entry name" value="SelW_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15124:SF17">
        <property type="entry name" value="SELENOPROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15124">
        <property type="entry name" value="SELENOPROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009454.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="35695" checksum="73AF0B7F899FFABB" modified="2022-05-25" version="3">MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTQTPVLTPSPARLPALVQPPAPAHIPTQVPTPALARIPGLVPPPARAWIPTPVPTPARVRNPTPVPTPARTLTPPVRVPAPAPAPDPAQVLAGIRTALPALDSYPAPALSLDSPPEPAPEPPLSPEEDPESAPSLKLIPSVSSEAGPALGPLLAHTPLAANSSGPTLDFTFRADPSATGLADPHVPSPVPAPILGTIPSALSLQNSTETLVSTSENFALDKRVLIRYILLKNSLEQQFPNHLLFEEDRAAQATGEFEVFVNGRLVHSKKRGDGFVNESGLQKIVSVIYEEIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWG2</accession>
    <name>A0A0A0MWG2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RAB3A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915217.1">
        <property type="nucleotide sequence ID" value="XM_003915168.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWG2"/>
    <dbReference type="SMR" id="A0A0A0MWG2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009480"/>
    <dbReference type="Ensembl" id="ENSPANT00000014894.3">
        <property type="protein sequence ID" value="ENSPANP00000009480.1"/>
        <property type="gene ID" value="ENSPANG00000009376.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011072"/>
    <dbReference type="KEGG" id="panu:101011072"/>
    <dbReference type="CTD" id="5864"/>
    <dbReference type="eggNOG" id="KOG0093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158959"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="OMA" id="CSMARDI"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009376">
        <property type="expression patterns" value="Expressed in amygdala and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060478">
        <property type="term" value="P:acrosomal vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061670">
        <property type="term" value="P:evoked neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903307">
        <property type="term" value="P:positive regulation of regulated secretory pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905684">
        <property type="term" value="P:regulation of plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099161">
        <property type="term" value="P:regulation of presynaptic dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031630">
        <property type="term" value="P:regulation of synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051602">
        <property type="term" value="P:response to electrical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050975">
        <property type="term" value="P:sensory perception of touch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097091">
        <property type="term" value="P:synaptic vesicle clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016188">
        <property type="term" value="P:synaptic vesicle maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="220" mass="24984" checksum="08B59F8C9BD2EB40" modified="2015-01-07" version="1">MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLSDQQVPPHQDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LC13</accession>
    <name>A0A2I3LC13_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LC13"/>
    <dbReference type="Ensembl" id="ENSPANT00000053672.2">
        <property type="protein sequence ID" value="ENSPANP00000020995.2"/>
        <property type="gene ID" value="ENSPANG00000040234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00580000082664"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003964">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LC13">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020995.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="160" mass="17826" checksum="D480BB579DC59CB3" modified="2022-05-25" version="2">MPLRGPSDACFTTFLMSSYLAGFSRRQVRSTTDTLAVGTWKAMPVSFPFSSGMTLPTALAAPVEAGMMFWRAPRPSRHSFPEGPSTVFWVAVMAWTVVMSPSTIPKLSWMTLARGAKQLVAQEGSRSWKMVMGLPLMTSFPFSAFTVPWNLPWVESYWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LP23</accession>
    <name>A0A2I3LP23_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="24">STEAP3 metalloreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">STEAP3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:71773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:71769"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STEAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LP23"/>
    <dbReference type="STRING" id="9555.ENSPANP00000025172"/>
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        <property type="protein sequence ID" value="ENSPANP00000025172.1"/>
        <property type="gene ID" value="ENSPANG00000019298.3"/>
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    <dbReference type="GeneTree" id="ENSGT00390000008042"/>
    <dbReference type="OMA" id="WTLQMGP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019298">
        <property type="expression patterns" value="Expressed in liver and 30 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LP23">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008823">
        <property type="term" value="F:cupric reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="STEAP2 metalloreductase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="METALLOREDUCTASE STEAP3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="262"/>
            <end position="290"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="315"/>
            <end position="336"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="369"/>
            <end position="389"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="401"/>
            <end position="422"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="23">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="22">
        <location>
            <begin position="271"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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            <dbReference type="ARBA" id="ARBA00022827"/>
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            <dbReference type="ARBA" id="ARBA00023004"/>
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            <dbReference type="ARBA" id="ARBA00023008"/>
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            <dbReference type="ARBA" id="ARBA00048958"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049387"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="498" mass="55473" checksum="88453DC6FCD96BED" modified="2018-02-28" version="1">MSHQPAVATKMSGEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTAGLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLSEQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICSDQPEAKRAVSEMALAMGFMPVDMGSLASAREVEAMPLRLLPAWKVPTLLALGLFVCFYAYNFVRDVLQPYMQESQNKFFKLPVSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFCAALHALYSFCLPLRRAHRYDLVNLAVKQVLANKSHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSIANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWTRAFEESRYKFYLPPTFTLTLLVPCVVILAKALFLLPCISRRLTRIRRGWERDGAIKFTLPTDHALAEKTSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LQM4</accession>
    <name>A0A2I3LQM4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KIAA2012</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KIAA2012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_017946794.3"/>
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        <property type="gene ID" value="ENSPANG00000025945.3"/>
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    <dbReference type="KEGG" id="panu:101015988"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="entry name" value="DUF4670"/>
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        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937:SF5">
        <property type="entry name" value="GENE 973-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15709">
        <property type="entry name" value="DUF4670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="376"/>
            <end position="400"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="433"/>
            <end position="562"/>
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            <begin position="1010"/>
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            <begin position="1090"/>
            <end position="1140"/>
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            <begin position="433"/>
            <end position="444"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="446"/>
            <end position="458"/>
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            <begin position="498"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025781.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1180" mass="135715" checksum="CDF9DD34334BA1EF" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LV06</accession>
    <name>A0A2I3LV06_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">Thyrotropin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">TSHR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 18">Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LV06"/>
    <dbReference type="STRING" id="9555.ENSPANP00000027277"/>
    <dbReference type="Ensembl" id="ENSPANT00000038912.2">
        <property type="protein sequence ID" value="ENSPANP00000027277.2"/>
        <property type="gene ID" value="ENSPANG00000007671.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156510"/>
    <dbReference type="OMA" id="TRDMRQS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007671">
        <property type="expression patterns" value="Expressed in thyroid gland and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004996">
        <property type="term" value="F:thyroid-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090103">
        <property type="term" value="P:cochlea morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hormone-mediated signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0060122">
        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of locomotion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="7tmA_TSH-R"/>
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        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thyrotropin receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="Gphrmn_rcpt_fam"/>
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    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="TSH_rcpt"/>
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        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
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        <property type="entry name" value="GLYCHORMONER"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="L domain-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 18" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="580"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="627"/>
            <end position="649"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="661"/>
            <end position="681"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="431"/>
            <end position="678"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003057"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011465"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361222"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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    </evidence>
    <sequence length="794" mass="90138" checksum="42D71FEF270DEA39" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M3V7</accession>
    <name>A0A2I3M3V7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T cell receptor beta variable 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRBV16</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M3V7"/>
    <dbReference type="Ensembl" id="ENSPANT00000049125.2">
        <property type="protein sequence ID" value="ENSPANP00000030421.1"/>
        <property type="gene ID" value="ENSPANG00000031766.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155819"/>
    <dbReference type="OMA" id="CAPIKGY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031766">
        <property type="expression patterns" value="Expressed in thymus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050413">
        <property type="entry name" value="TCR_beta_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268:SF24">
        <property type="entry name" value="T CELL RECEPTOR BETA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268">
        <property type="entry name" value="T-CELL RECEPTOR BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="103" mass="11670" checksum="F2FCF0F4E1095D5F" modified="2018-02-28" version="1">GEEVTQTPKHLVKGEGQKAKLYCDPIKGHSYVFWYQQVLRKEFKFLISFQNKNVFDETGMPKERFSAKCPANSPCSLEIQATKLKDSAVYFCASSQSTVLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M6N6</accession>
    <name>A0A2I3M6N6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Complement factor I</fullName>
            <ecNumber evidence="17">3.4.21.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C3B/C4B inactivator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">CFI</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.</text>
            <dbReference type="EC" id="3.4.21.45"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.45" evidence="17"/>
    <dbReference type="RefSeq" id="XP_021794394.2">
        <property type="nucleotide sequence ID" value="XM_021938702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M6N6"/>
    <dbReference type="Ensembl" id="ENSPANT00000042963.2">
        <property type="protein sequence ID" value="ENSPANP00000031406.2"/>
        <property type="gene ID" value="ENSPANG00000019215.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023963"/>
    <dbReference type="KEGG" id="panu:101023963"/>
    <dbReference type="CTD" id="3426"/>
    <dbReference type="GeneTree" id="ENSGT00930000151042"/>
    <dbReference type="OMA" id="YECQQPK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019215">
        <property type="expression patterns" value="Expressed in liver and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M6N6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000066">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000018">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000027">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000129">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000163">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048722">
        <property type="entry name" value="CFAI_FIMAC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048719">
        <property type="entry name" value="CFAI_KAZAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF27">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21286">
        <property type="entry name" value="CFAI_FIMAC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21287">
        <property type="entry name" value="Kazal_CFAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="14 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 22" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035300818" description="Complement factor I" evidence="23">
        <location>
            <begin position="19"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="26">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="25">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="24">
        <location>
            <begin position="366"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031406.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="611" mass="68267" checksum="71D239D2CE15703D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7Z8</accession>
    <name>A0A2I3M7Z8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuroligin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NLGN2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912298.1">
        <property type="nucleotide sequence ID" value="XM_003912249.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031513200.1">
        <property type="nucleotide sequence ID" value="XM_031657340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M7Z8"/>
    <dbReference type="ESTHER" id="papan-a0a096p2p7">
        <property type="family name" value="Neuroligin"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000040033.2">
        <property type="protein sequence ID" value="ENSPANP00000031764.2"/>
        <property type="gene ID" value="ENSPANG00000024185.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100998480"/>
    <dbReference type="KEGG" id="panu:100998480"/>
    <dbReference type="CTD" id="57555"/>
    <dbReference type="GeneTree" id="ENSGT00940000160598"/>
    <dbReference type="OMA" id="APKPCLM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024185">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M7Z8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098691">
        <property type="term" value="C:dopaminergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098690">
        <property type="term" value="C:glycinergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098984">
        <property type="term" value="C:neuron to neuron synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0097116">
        <property type="term" value="P:gephyrin clustering involved in postsynaptic density assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035641">
        <property type="term" value="P:locomotory exploration behavior"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072578">
        <property type="term" value="P:neurotransmitter-gated ion channel clustering"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000463">
        <property type="term" value="P:positive regulation of excitatory postsynaptic potential"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097151">
        <property type="term" value="P:positive regulation of inhibitory postsynaptic potential"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1902474">
        <property type="term" value="P:positive regulation of protein localization to synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000809">
        <property type="term" value="P:positive regulation of synaptic vesicle clustering"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097119">
        <property type="term" value="P:postsynaptic density protein 95 clustering"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097104">
        <property type="term" value="P:postsynaptic membrane assembly"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097105">
        <property type="term" value="P:presynaptic membrane assembly"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002087">
        <property type="term" value="P:regulation of respiratory gaseous exchange by nervous system process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051932">
        <property type="term" value="P:synaptic transmission, GABAergic"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="15">
        <location>
            <begin position="43"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="624"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031764.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="836" mass="90907" checksum="0FA56985E4A325E6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M804</accession>
    <name>A0A2I3M804_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Putative ATP-dependent RNA helicase TDRD12</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ES cell-associated transcript 8 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tudor domain-containing protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TDRD12</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of a mRNP complex containing PIWIL2, TDRD1 and piRNAs. Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031850"/>
    <dbReference type="Ensembl" id="ENSPANT00000052458.2">
        <property type="protein sequence ID" value="ENSPANP00000031850.2"/>
        <property type="gene ID" value="ENSPANG00000001203.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029847"/>
    <dbReference type="OMA" id="KMHKEVV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001203">
        <property type="expression patterns" value="Expressed in testis and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M804">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
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        <property type="term" value="P:germ-line stem cell division"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
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        <property type="term" value="P:spermatogenesis"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
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        <property type="entry name" value="TUDOR"/>
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        <property type="entry name" value="HSP20-like chaperones"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="Tudor/PWWP/MBT"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7" id="KW-0347">Helicase</keyword>
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    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="663"/>
            <end position="824"/>
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        <location>
            <begin position="1191"/>
            <end position="1277"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1102"/>
            <end position="1187"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1105"/>
            <end position="1119"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1160"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
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            <dbReference type="ARBA" id="ARBA00023158"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062399"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00068835"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076714"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031850.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1333" mass="151121" checksum="DD6DF0F7FBBB00E3" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M8C0</accession>
    <name>A0A2I3M8C0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTF2I repeat domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GTF2IRD1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M8C0"/>
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        <property type="protein sequence ID" value="ENSPANP00000031997.2"/>
        <property type="gene ID" value="ENSPANG00000024960.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159414"/>
    <dbReference type="OMA" id="VFDVLYX"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024960">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M8C0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014886">
        <property type="term" value="P:transition between slow and fast fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1460.10:FF:000005">
        <property type="entry name" value="general transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1460.10:FF:000007">
        <property type="entry name" value="General transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1460.10:FF:000008">
        <property type="entry name" value="General transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.1460.10">
        <property type="entry name" value="GTF2I-like"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="GTF2I"/>
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    <dbReference type="InterPro" id="IPR036647">
        <property type="entry name" value="GTF2I-like_rpt_sf"/>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
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    <dbReference type="PANTHER" id="PTHR46304:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GTF2I-like repeat"/>
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    <dbReference type="PROSITE" id="PS51139">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="5"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="856"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031997.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="923" mass="101681" checksum="BCC7C07D1946E7C0" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MDH3</accession>
    <name>A0A2I3MDH3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix hydrolase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NUDT13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MDH3"/>
    <dbReference type="Ensembl" id="ENSPANT00000039651.2">
        <property type="protein sequence ID" value="ENSPANP00000033650.1"/>
        <property type="gene ID" value="ENSPANG00000022364.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158879"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022364">
        <property type="expression patterns" value="Expressed in gastrocnemius and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MDH3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000003">
        <property type="entry name" value="Nucleoside diphosphate-linked moiety X motif 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11383:SF3">
        <property type="entry name" value="NAD(P)H PYROPHOSPHATASE NUDT13, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11383">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH pyrophosphatase-like N-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc ribbon NADH pyrophosphatase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="263" mass="30173" checksum="C95F60E3FE39E4EB" modified="2018-02-28" version="1">MFLYCGIACRRKFFWCYRLLSTYVTKTRYLFELKEDDDACKKAQQTGAFYLFHGLAPLLQTSAHQYLAPRHSLLELERLLGKFGQDAQRIEDSVLIGCSEQQEAWFALDLGLDSSFSIRASLHKPEMETELKGSFIELRKALFQLNARDASMLSTAQALLRWHDAHQFCSRSGQPTKKNVAGSKRVCPSNNIIYYPQIQVNLRELETAAWFSHDEVATALKRKGPYTQQQNGTFPFWLPPKLAISHQLIKEWVEKQTCSSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MEF8</accession>
    <name>A0A2I3MEF8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPANT00000041721.2">
        <property type="protein sequence ID" value="ENSPANP00000033965.1"/>
        <property type="gene ID" value="ENSPANG00000003889.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162519"/>
    <dbReference type="OMA" id="AAHNTIN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003889">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MEF8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014118631" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="115" mass="11881" checksum="DB0ADCC0F77ACA20" modified="2018-02-28" version="1">MRGASYLQILLLVLGAAGTQGRKSATCGQPRVSSRIVGGRDARDGEWPWQASIQHRGAHVCGRSLIALQWVLTAAHCFPSAPPRVAAATGSKGTAAGLAHLRPPLPRGRGGAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MM66</accession>
    <name>A0A2I3MM66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein S100</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">S100 calcium-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Facilitates the differentiation and the cornification of keratinocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MM66"/>
    <dbReference type="STRING" id="9555.ENSPANP00000036711"/>
    <dbReference type="Ensembl" id="ENSPANT00000032935.2">
        <property type="protein sequence ID" value="ENSPANP00000036711.2"/>
        <property type="gene ID" value="ENSPANG00000033346.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154172"/>
    <dbReference type="OMA" id="HERCMES"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033346">
        <property type="expression patterns" value="Expressed in thymus and 48 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05023">
        <property type="entry name" value="S-100A11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000188">
        <property type="entry name" value="Protein S100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028482">
        <property type="entry name" value="S100A11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF60">
        <property type="entry name" value="PROTEIN S100-A11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036711.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="104" mass="11686" checksum="647004F2E2662663" modified="2022-05-25" version="2">MAKVSSPTEIERCLESLIAVFQKYAGKDGYNYILSKTEFLSFMNTELAAFTKNQDPGVLDRMVKRLDTNSDGQLDFLEFLNLISGLAMACHDSFLKAVPSQKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MNG7</accession>
    <name>A0A2I3MNG7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MNG7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037267"/>
    <dbReference type="Ensembl" id="ENSPANT00000051319.2">
        <property type="protein sequence ID" value="ENSPANP00000037267.2"/>
        <property type="gene ID" value="ENSPANG00000033882.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182922"/>
    <dbReference type="OMA" id="NGMPHRC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033882">
        <property type="expression patterns" value="Expressed in putamen and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037267.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="84" mass="9451" checksum="BF74D02DDF25D596" modified="2022-05-25" version="2">MMNAKGKRRGTRYMFSRKHGTVPLATYMQIYKKGDIVNIKGIGTVQNGMPHRCYHGKTGRVYNVPQHAVGIVVNKQGQDSCQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MP96</accession>
    <name>A0A2I3MP96_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAM and LDL-receptor class A domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MALRD1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031508570.1">
        <property type="nucleotide sequence ID" value="XM_031652710.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000037569"/>
    <dbReference type="Ensembl" id="ENSPANT00000041754.2">
        <property type="protein sequence ID" value="ENSPANP00000037569.2"/>
        <property type="gene ID" value="ENSPANG00000029973.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101015969"/>
    <dbReference type="KEGG" id="panu:101015969"/>
    <dbReference type="CTD" id="340895"/>
    <dbReference type="GeneTree" id="ENSGT00940000158809"/>
    <dbReference type="OMA" id="HLVCDNK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029973">
        <property type="expression patterns" value="Expressed in ileum and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070858">
        <property type="term" value="P:negative regulation of bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000129">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000135">
        <property type="entry name" value="LDL receptor protein 1, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000232">
        <property type="entry name" value="MAM and LDL receptor class A domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000240">
        <property type="entry name" value="MAM and LDL receptor class A domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000191">
        <property type="entry name" value="MAM and LDL receptor class A domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000205">
        <property type="entry name" value="MAM and LDL receptor class A domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000225">
        <property type="entry name" value="MAM and LDL receptor class A domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000142">
        <property type="entry name" value="MAM and LDL receptor class A domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000975">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000182">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000206">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000254">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000297">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000182">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000186">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000067">
        <property type="entry name" value="Serine peptidase inhibitor, Kunitz type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF140">
        <property type="entry name" value="MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035230144" description="MAM and LDL-receptor class A domain-containing protein 1" evidence="15">
        <location>
            <begin position="32"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2075"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="268"/>
            <end position="427"/>
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    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="474"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="652"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="863"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="1088"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="1305"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="1519"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="1727"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2023"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1264"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1271"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1483"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1502"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1692"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1704"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1923"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1947"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1954"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1966"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2047"/>
            <end position="2056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037569.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2163" mass="242144" checksum="8B8FCAF42AF22F84" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MS52</accession>
    <name>A0A2I3MS52_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphodiesterase</fullName>
            <ecNumber evidence="11">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PDE1C</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16958"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:14654"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MS52"/>
    <dbReference type="STRING" id="9555.ENSPANP00000038598"/>
    <dbReference type="Ensembl" id="ENSPANT00000045456.2">
        <property type="protein sequence ID" value="ENSPANP00000038598.2"/>
        <property type="gene ID" value="ENSPANG00000023668.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155331"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023668">
        <property type="expression patterns" value="Expressed in heart and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MS52">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004117">
        <property type="term" value="F:calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000032">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013706">
        <property type="entry name" value="PDE1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08499">
        <property type="entry name" value="PDEase_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="14">
        <location>
            <begin position="165"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="565"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038598.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="664" mass="76721" checksum="FAE064FD80712501" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N2K9</accession>
    <name>A0A2I3N2K9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein 544</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N2K9"/>
    <dbReference type="Ensembl" id="ENSPANT00000039920.2">
        <property type="protein sequence ID" value="ENSPANP00000042135.2"/>
        <property type="gene ID" value="ENSPANG00000008310.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182890"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008310">
        <property type="expression patterns" value="Expressed in heart and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N2K9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000355">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000622">
        <property type="entry name" value="zinc finger protein 26 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002215">
        <property type="entry name" value="Zinc finger protein 544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000934">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF394">
        <property type="entry name" value="ZINC FINGER PROTEIN 544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042135.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N573</accession>
    <name>A0A2I3N573_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">KIAA0825</fullName>
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        <name evidence="1" type="primary">KIAA0825</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSPANP00000043017.2"/>
        <property type="gene ID" value="ENSPANG00000007936.3"/>
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    <dbReference type="OMA" id="WEMKKDE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="Bgee" id="ENSPANG00000007936">
        <property type="expression patterns" value="Expressed in olfactory bulb and 66 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="entry name" value="DUF4495"/>
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    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="F138DOMAIN"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043017.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1277" mass="146657" checksum="9A1F41A3B681E304" modified="2022-05-25" version="2"> </sequence>
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<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N7G2</accession>
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        <submittedName>
            <fullName evidence="10">Lectin, mannose binding 1 like</fullName>
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        <name evidence="10" type="primary">LMAN1L</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
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                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <property type="protein sequence ID" value="ENSPANP00000043816.2"/>
        <property type="gene ID" value="ENSPANG00000016001.3"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="expression patterns" value="Expressed in spleen and 13 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3N7G2">
        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Blast:Protein ERGIC-53"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF31">
        <property type="entry name" value="PROTEIN ERGIC-53-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236927" evidence="8">
        <location>
            <begin position="26"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="31"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043816.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="508" mass="55416" checksum="B5F44CE762A935AB" modified="2022-05-25" version="2">MPVVNGPGLLFCLLLLLLEPHSPETACPALRRFEYKLSFKGPRLALPGAGIPFWSHHGDAILGLEEVRLTPSMRNRSGAVWSRASVLFSAWEVEVQMRVTGLGRRGAQGMAVWYTQGRGHVGSILRGLASWDGIGIFFDSSAEDTQNSPAIRVLASDGHIPSEQPGYGASQVLGSCHWDFRNRPHPFRARITYWGQRLCVSLNSGLTPSDPDEFCVDVGPLLLVPGGFFGVSAATGILADDHDVLSFLTFSPSESSPEVPPQPFLEMEQLRLARQLEGLRARLGLGTREDVTPKSGSEAQGEGERLFDLEEMLGRHSQILQALRGLSEQLAQAERQWKQQLGPPGQARPDGGWALDLSKDSAKVDALLHGQRTLLQALQEMRDAAVRMAAEAQVSYLPVGTEHHFLELDHILGLLQKELQGPAKAAAKAPRPPGQPPRASSCLHPGIFLFFLLIQTVGFFSYVHFRQELNESLQECLSTGSLSLGPAPYIPRAPGILRRQPLPASMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NBY3</accession>
    <name>A0A2I3NBY3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Adhesion G protein-coupled receptor E3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ADGRE3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3NBY3"/>
    <dbReference type="Ensembl" id="ENSPANT00000036984.2">
        <property type="protein sequence ID" value="ENSPANP00000045417.2"/>
        <property type="gene ID" value="ENSPANG00000019561.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163037"/>
    <dbReference type="OMA" id="NYSNMNR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019561">
        <property type="expression patterns" value="Expressed in bone marrow and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NBY3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000054">
        <property type="entry name" value="Adhesion G protein-coupled receptor E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001740">
        <property type="entry name" value="GPCR_2_EMR1-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF455">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01128">
        <property type="entry name" value="EMR1HORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="14">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="105"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045417.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="441" mass="49136" checksum="410E9621F4ADF29A" modified="2022-05-25" version="2">SGSPEVRSSDQLVQHGPSRVAFISYSSLGNIINSVTLTFQHVKMNHSIKKAFCVYWETTKQGGLWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMAFTSQEEDPVLTIITYVGLSLSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFVAHLLFLVGIDQTESKVLCAIIAGALHYLYLAAFTWMLLEGLHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVAISAASRPHLYGTADRCWLHLDQGFIWGFLGPVCAIFSVNLVFFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTWCLGFLQVGPAAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQKQYQKWFREIVKSKSESETYTLSSKVGPDSKPSEVSEHVNCSNVLYTPLLTLQTSSSLEVFVCLFVCLFVLSSEVTRTGCAGLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NGP3</accession>
    <name>A0A2I3NGP3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Parvalbumin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the parvalbumin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031665608.1"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000047252"/>
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        <property type="protein sequence ID" value="ENSPANP00000047252.2"/>
        <property type="gene ID" value="ENSPANG00000033390.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101009274"/>
    <dbReference type="KEGG" id="panu:101009274"/>
    <dbReference type="CTD" id="654231"/>
    <dbReference type="GeneTree" id="ENSGT00940000161875"/>
    <dbReference type="OMA" id="NWLARIC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033390">
        <property type="expression patterns" value="Expressed in optic disc and 42 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16255">
        <property type="entry name" value="EFh_parvalbumin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000060">
        <property type="entry name" value="Parvalbumin, thymic"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008080">
        <property type="entry name" value="Parvalbumin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653:SF16">
        <property type="entry name" value="ONCOMODULIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653">
        <property type="entry name" value="PARVALBUMIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
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        <ligand>
            <name>Ca(2+)</name>
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    <feature type="binding site" evidence="5">
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            <position position="91"/>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="5">
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            <position position="95"/>
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        <ligand>
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            <position position="97"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608080-1"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047252.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="112" mass="12234" checksum="995CA8167D6FBCD3" modified="2022-05-25" version="2">MSITDVLSADDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQVKDIFRFIDNDQSGYLDEEELKFFLQKFESGARELTESETKSLMAAADNDGDGKIGAEGTSAPVRSIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N236</accession>
    <name>A0A8I5N236_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000037015.1"/>
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        <property type="component" value="Chromosome 20"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053551.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="131" mass="14883" checksum="43DA94CB64D096FD" modified="2022-05-25" version="1">MDKKECHEESSSSDEELLRRIYRELSPVSQICGSILHFFDEDDETEAEALWFTAFPKYQPSGEDIPSVSEQQESSEGQESGDICSEENQIVSSYAAKLGFEVEQDYTNHQFLGPEGNVDVELIDKSTNTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N350</accession>
    <name>A0A8I5N350_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="Ensembl" id="ENSPANT00000061721.1">
        <property type="protein sequence ID" value="ENSPANP00000054271.1"/>
        <property type="gene ID" value="ENSPANG00000041722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="CITCARI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1142" mass="132966" checksum="F49A2C41A4760CCE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N3W5</accession>
    <name>A0A8I5N3W5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N3W5"/>
    <dbReference type="Ensembl" id="ENSPANT00000074118.1">
        <property type="protein sequence ID" value="ENSPANP00000054823.1"/>
        <property type="gene ID" value="ENSPANG00000048335.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183013"/>
    <dbReference type="OMA" id="TTAYMEL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000556">
        <property type="entry name" value="Immunoglobulin heavy variable 7-81 (non-functional)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="101" mass="10937" checksum="F2FEF0F6379BF24B" modified="2022-05-25" version="1">QVQLVQSGAEVKKPGASVKLSCKASGFTFISYAISWVRQAPGQGLEWMGEIIPAFGIADYAQKFQGRVTITADTSTSTAYMELSSLRSEDTAVYYCARDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N487</accession>
    <name>A0A8I5N487_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dachshund family transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DACH1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DACH/dachshund family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N487"/>
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        <property type="protein sequence ID" value="ENSPANP00000053753.1"/>
        <property type="gene ID" value="ENSPANG00000020947.3"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:development of primary female sexual characteristics"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060244">
        <property type="term" value="P:negative regulation of cell proliferation involved in contact inhibition"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000279">
        <property type="term" value="P:negative regulation of DNA biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of transcription by competitive promoter binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:suckling behavior"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:type B pancreatic cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
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        <property type="entry name" value="SKI/SNO/DAC"/>
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        <property type="entry name" value="Ski_DNA-bd_sf"/>
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        <property type="entry name" value="DACHSHUND HOMOLOG 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="Pfam" id="PF02437"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N658</accession>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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        <name evidence="15" type="primary">DDX3Y</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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        </reaction>
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        <text evidence="7">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
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    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
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            <begin position="179"/>
            <end position="207"/>
        </location>
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            <end position="402"/>
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            <begin position="413"/>
            <end position="574"/>
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            <end position="142"/>
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            <begin position="580"/>
            <end position="629"/>
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            <begin position="179"/>
            <end position="207"/>
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            <begin position="1"/>
            <end position="10"/>
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            <begin position="15"/>
            <end position="35"/>
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        <source>
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        <source>
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        <source>
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    <sequence length="661" mass="73329" checksum="ECE71D08762BB871" modified="2022-05-25" version="1"> </sequence>
</entry>
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    <name>A0A8I5N6N5_PAPAN</name>
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            <fullName evidence="10">H1.2 linker histone, cluster member</fullName>
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        <name evidence="10" type="primary">H1-2</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031518076.1">
        <property type="nucleotide sequence ID" value="XM_031662216.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031518077.1">
        <property type="nucleotide sequence ID" value="XM_031662217.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522428.1">
        <property type="nucleotide sequence ID" value="XM_031666568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NAM0"/>
    <dbReference type="Ensembl" id="ENSPANT00000075852.1">
        <property type="protein sequence ID" value="ENSPANP00000057149.1"/>
        <property type="gene ID" value="ENSPANG00000049810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101023407"/>
    <dbReference type="GeneID" id="116273265"/>
    <dbReference type="KEGG" id="panu:116273265"/>
    <dbReference type="CTD" id="134353"/>
    <dbReference type="GeneTree" id="ENSGT00390000012944"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005683">
        <property type="term" value="C:U7 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071209">
        <property type="term" value="F:U7 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01739">
        <property type="entry name" value="LSm11_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000158">
        <property type="entry name" value="LSM11, U7 small nuclear RNA associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039267">
        <property type="entry name" value="Lsm11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034109">
        <property type="entry name" value="Lsm11_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415:SF1">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="266"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="361" mass="39801" checksum="A1FB54945809B380" modified="2022-05-25" version="1">MEERERGARSARAASPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLRTGVRGGGRGRGRARGAAAGSGVPSAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDGAAGVGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRGDTDRGSHKRSRSVPSSLQASAREESRSELSGRTTRTEGSSVGGTFSRATTLSRSQSRKKKRKPKVDYQQTRLNRMTLPIYTFTAHIPAATRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBX7</accession>
    <name>A0A8I5NBX7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Thrombospondin 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBX7"/>
    <dbReference type="Ensembl" id="ENSPANT00000067823.1">
        <property type="protein sequence ID" value="ENSPANP00000055660.1"/>
        <property type="gene ID" value="ENSPANG00000050000.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159283"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000004">
        <property type="entry name" value="Cartilage oligomeric matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000025">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000002">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000001">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000170">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000232">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024665">
        <property type="entry name" value="TSP/COMP_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF89">
        <property type="entry name" value="THROMBOSPONDIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11598">
        <property type="entry name" value="COMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="648"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="13">
        <location>
            <begin position="687"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="506"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="99847" checksum="20EFA1B727ACD132" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NES4</accession>
    <name>A0A8I5NES4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF311</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202944.2">
        <property type="nucleotide sequence ID" value="XM_009204680.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202945.2">
        <property type="nucleotide sequence ID" value="XM_009204681.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813212.2">
        <property type="nucleotide sequence ID" value="XM_017957723.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NES4"/>
    <dbReference type="Ensembl" id="ENSPANT00000072443.1">
        <property type="protein sequence ID" value="ENSPANP00000058722.1"/>
        <property type="gene ID" value="ENSPANG00000047970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101020895"/>
    <dbReference type="KEGG" id="panu:101020895"/>
    <dbReference type="CTD" id="282890"/>
    <dbReference type="GeneTree" id="ENSGT00940000163512"/>
    <dbReference type="OMA" id="EPCVQDP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000111">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001181">
        <property type="entry name" value="Zinc finger protein 311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002471">
        <property type="entry name" value="Zinc finger protein 311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000187">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF366">
        <property type="entry name" value="ZINC FINGER PROTEIN ZFP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="634"/>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
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                <person name="Fernandez S.F."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gubbala S.G."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
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                <person name="Aqrawi P.A."/>
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                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
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                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
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                <person name="Johnson B.J."/>
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                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
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                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Simmons D.S."/>
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                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
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                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Worley K.W."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 and GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003916789.1">
        <property type="nucleotide sequence ID" value="XM_003916740.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIV5"/>
    <dbReference type="SMR" id="A0A8I5NIV5"/>
    <dbReference type="Ensembl" id="ENSPANT00000062925.1">
        <property type="protein sequence ID" value="ENSPANP00000059501.1"/>
        <property type="gene ID" value="ENSPANG00000006187.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005722"/>
    <dbReference type="KEGG" id="panu:101005722"/>
    <dbReference type="CTD" id="5531"/>
    <dbReference type="GeneTree" id="ENSGT00930000151040"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="307" mass="35080" checksum="D6FE470A5C6CBCAC" modified="2022-05-25" version="1">MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKU5</accession>
    <name>A0A8I5NKU5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKU5"/>
    <dbReference type="Ensembl" id="ENSPANT00000080679.1">
        <property type="protein sequence ID" value="ENSPANP00000050471.1"/>
        <property type="gene ID" value="ENSPANG00000043144.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="465" mass="51237" checksum="21310657FB6BA43F" modified="2022-05-25" version="1">MVYDHVEGLFFSTSCAALRKEIVCVCVCVCVCVRERETESRSVAQTDVQWHDLSSLQPPPPCSSNSPASASGVAGIIGTRHHARLMFVFLVETGFHHVGQAGLKLLTSSDPPALASKNSGITGVSHRAQPGRRLNSTFPGNTLCICSFRQQIFLELLLGTEHCNGASQGPCFPGTNRPMGWAGSGEYGGIGRETGHQSSGQHQDWDLKGLPSRWDMRGQERPRGKEVETGIKSLGELECGGCGCSTQRVSLLRGSAQKGDFFFSLSLYIFIYLFIETGSCSIAQAGVQWCNHGSLYPQPPRLKQSSCLSFASHRDHRYAPPCLAYFLFFVETGSHYVALAGLKLLTSSNSPTSASQSAGIRGMSNQPQRGISYRIQEPHWHYLQLPFDPRRPFSRTWVHAPCLALLYMHIISAQWASEFLTRTEPMSLWLPCFLAQCQVHSRAQCLLDDSVCCKFMISHREGIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NM75</accession>
    <name>A0A8I5NM75_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NM75"/>
    <dbReference type="Ensembl" id="ENSPANT00000071355.1">
        <property type="protein sequence ID" value="ENSPANP00000059412.1"/>
        <property type="gene ID" value="ENSPANG00000047952.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="89" mass="10023" checksum="2BAC411E3A72D319" modified="2022-05-25" version="1">MLKTYAEFMGFFVCLFEAESRSVTQAGVQWPDLSSLQAPPPGFTPFSCLSLPSSWDYRRPPPRPASFLYFLVETGFHRVSQDGLNLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NM89</accession>
    <name>A0A8I5NM89_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Short transmembrane mitochondrial protein 1</fullName>
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        <name evidence="2" type="primary">STMP1</name>
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    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_003896640.5"/>
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    <dbReference type="Ensembl" id="ENSPANT00000069406.1">
        <property type="protein sequence ID" value="ENSPANP00000054189.1"/>
        <property type="gene ID" value="ENSPANG00000045737.1"/>
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    <dbReference type="KEGG" id="panu:100998245"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="STMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47709">
        <property type="entry name" value="SHORT TRANSMEMBRANE MITOCHONDRIAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47709:SF2">
        <property type="entry name" value="SHORT TRANSMEMBRANE MITOCHONDRIAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15054">
        <property type="entry name" value="DUF4535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035149931" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="47" mass="5265" checksum="A2B4B037CBED539F" modified="2022-05-25" version="1">MLQFLLGFTLGNVVGMYLAQNYDIPNLAKKLEEIKKDLDAKKKPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMT8</accession>
    <name>A0A8I5NMT8_PAPAN</name>
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        <recommendedName>
            <fullName evidence="20">CD2-associated protein</fullName>
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    <gene>
        <name evidence="25" type="primary">CD2AP</name>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">(Microbial infection) Interacts (via SH3 domains) with Chikungunya virus non-structural protein 3 (via C-terminus); this interaction plays a role in initiation of viral replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003897749.1">
        <property type="nucleotide sequence ID" value="XM_003897700.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NMT8"/>
    <dbReference type="Ensembl" id="ENSPANT00000066199.1">
        <property type="protein sequence ID" value="ENSPANP00000049995.1"/>
        <property type="gene ID" value="ENSPANG00000026002.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013052"/>
    <dbReference type="KEGG" id="panu:101013052"/>
    <dbReference type="CTD" id="23607"/>
    <dbReference type="GeneTree" id="ENSGT00940000157566"/>
    <dbReference type="OMA" id="SKXKPKK"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036057">
        <property type="term" value="C:slit diaphragm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036312">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulatory subunit binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048668">
        <property type="term" value="P:collateral sprouting"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003158">
        <property type="term" value="P:endothelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001771">
        <property type="term" value="P:immunological synapse formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051674">
        <property type="term" value="P:localization of cell"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048535">
        <property type="term" value="P:lymph node development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035633">
        <property type="term" value="P:maintenance of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051058">
        <property type="term" value="P:negative regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032911">
        <property type="term" value="P:negative regulation of transforming growth factor beta1 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038180">
        <property type="term" value="P:nerve growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048011">
        <property type="term" value="P:neurotrophin TRK receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072112">
        <property type="term" value="P:podocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051291">
        <property type="term" value="P:protein heterooligomerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097018">
        <property type="term" value="P:renal albumin absorption"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990790">
        <property type="term" value="P:response to glial cell derived neurotrophic factor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071559">
        <property type="term" value="P:response to transforming growth factor beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032905">
        <property type="term" value="P:transforming growth factor beta1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12053">
        <property type="entry name" value="SH3_CD2AP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12054">
        <property type="entry name" value="SH3_CD2AP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12056">
        <property type="entry name" value="SH3_CD2AP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000094">
        <property type="entry name" value="SH3 domain-containing kinase-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000112">
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        <property type="entry name" value="Unconventional Myosin IB"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="CD2AP_SH3_1"/>
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        <property type="entry name" value="CD2-ASSOCIATED PROTEIN"/>
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        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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            <begin position="583"/>
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            <begin position="168"/>
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            <begin position="184"/>
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            <begin position="341"/>
            <end position="351"/>
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            <begin position="356"/>
            <end position="379"/>
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            <begin position="385"/>
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            <begin position="398"/>
            <end position="407"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022618"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056655"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065859"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069668"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049995.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="639" mass="71315" checksum="31EC0F17720FEAE3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NRY6</accession>
    <name>A0A8I5NRY6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor family 2 subfamily I member 1 (gene/pseudogene)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Olfactory receptor family 2 subfamily I member 1 pseudogene</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OR2I1P</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="gene ID" value="ENSPANG00000045881.1"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004930">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Putative olfactory receptor 2I1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="OLFACTORYR"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <end position="47"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="119"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
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            <begin position="40"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="315" mass="34123" checksum="EC9E95545A3BB64A" modified="2022-05-25" version="1">MKANYSTEERFLLLGFSDWPSLQPVLFALVLLCYLLTLTGNSVLVLLTVRDPRLHTPMYYFLCHLALVDAGFTTSVVPPLLANLRGPALWLPRSHCMAQLCASLALGSAECVLLAVMALDRAAAVCRPLRYAGLASPRLCRALASASWLGGLTNSVAQTALLAERPLCGPRLLDHFICELPALLKLACGGDGDTTENQMFAARVVILLLPSAVILASYGAVARAVCCMRSSGGRRRAMGTCGSHLTVVCLFYGSAIYTYLQPAQRYNQARGKFVSLFYTVVTPALNPLIYTLRNKEVKGAARRLLWSLGRGQAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NV30</accession>
    <name>A0A8I5NV30_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA-box binding protein associated factor 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031507403.1">
        <property type="nucleotide sequence ID" value="XM_031651543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NV30"/>
    <dbReference type="Ensembl" id="ENSPANT00000068572.1">
        <property type="protein sequence ID" value="ENSPANP00000053982.1"/>
        <property type="gene ID" value="ENSPANG00000042313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101002873"/>
    <dbReference type="KEGG" id="panu:101002873"/>
    <dbReference type="CTD" id="6884"/>
    <dbReference type="GeneTree" id="ENSGT01050000245573"/>
    <dbReference type="OMA" id="FFERTHK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10662" checksum="954FB413CCE0FF22" modified="2022-05-25" version="1">MRKKTPPLRKKMKKLEEVQKVDRVKERDFFLKNTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NVG5</accession>
    <name>A0A8I5NVG5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDUFA8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003911332.1">
        <property type="nucleotide sequence ID" value="XM_003911283.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NVG5"/>
    <dbReference type="Ensembl" id="ENSPANT00000064704.1">
        <property type="protein sequence ID" value="ENSPANP00000054318.1"/>
        <property type="gene ID" value="ENSPANG00000042514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025936"/>
    <dbReference type="KEGG" id="panu:101025936"/>
    <dbReference type="CTD" id="4702"/>
    <dbReference type="GeneTree" id="ENSGT00390000008938"/>
    <dbReference type="OMA" id="FRTHWQC"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="14">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="172" mass="20082" checksum="D6F3E09A4B0F3599" modified="2022-05-25" version="1">MPGIVELPTLEELKVDEVKVSSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKEQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPEPSPEIKGDLKPAIHGSHFFFWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P1I5</accession>
    <name>A0A8I5P1I5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FXYD domain-containing ion transport regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FXYD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5P1I5"/>
    <dbReference type="Ensembl" id="ENSPANT00000071132.1">
        <property type="protein sequence ID" value="ENSPANP00000058375.1"/>
        <property type="gene ID" value="ENSPANG00000038668.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234872"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043269">
        <property type="term" value="P:regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.780">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000272">
        <property type="entry name" value="Ion-transport_regulator_FXYD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14132:SF20">
        <property type="entry name" value="FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14132">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02038">
        <property type="entry name" value="ATP1G1_PLM_MAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339140" description="FXYD domain-containing ion transport regulator" evidence="7">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="108" mass="11758" checksum="3190346E5F06921C" modified="2022-05-25" version="1">MEVVLIFLCSLLALIVLAGAADREKEIDPLHYDHQTLRTGGLVCAVVLFSTGILLILGCRSKCSFNQKGPQERRKPSGEPHHCKCNKDPESGELNEVQPSGWSAVAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZE4</accession>
    <name>A0A8I5QZE4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZE4"/>
    <dbReference type="Ensembl" id="ENSPANT00000073403.1">
        <property type="protein sequence ID" value="ENSPANP00000048982.1"/>
        <property type="gene ID" value="ENSPANG00000039768.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="NIEYATR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="15">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="14">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="16">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="39596" checksum="C4CB5B0568B99B50" modified="2022-05-25" version="1">MGKKQGRKAGNSKNKSASPPAKERSSSPATDQSWTENDFDEMREEGFSPSNFSELKEELRTQRKETKNLEKKVEELMARVINAEKVINEMKEMKTMTREIRDKCTSFSNQLDQLEERVSAIEDQMNEMKREEKPKEKRRKRNEQSLQEVWDYVKRPNLRLIGVPESEGENGTKLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSSRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTADLSAETLQARREWGPIFNILKEKNFKPRISYPAKLSFISEGEIKSFTDKQMLRDFVTTRPALQETLKEVLNMERNNRYQPSQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZR8</accession>
    <name>A0A8I5QZR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZR8"/>
    <dbReference type="Ensembl" id="ENSPANT00000062756.1">
        <property type="protein sequence ID" value="ENSPANP00000049990.1"/>
        <property type="gene ID" value="ENSPANG00000044669.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035182139" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11124" checksum="64F6F89656D89E91" modified="2022-05-25" version="1">MEARILSQSRPSMFLCLFFFFFFFETECRSVAQAGVQQRHLSSLQAPPPGFTPFSCLSLPSSWDYRRPPPRPASFLYFLVETGFHCVSQDGLYLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R1A8</accession>
    <name>A0A8I5R1A8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R1A8"/>
    <dbReference type="Ensembl" id="ENSPANT00000078899.1">
        <property type="protein sequence ID" value="ENSPANP00000055501.1"/>
        <property type="gene ID" value="ENSPANG00000048009.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="357" mass="38245" checksum="B6CEEFC2C6608EDD" modified="2022-05-25" version="1">VTPEGHSKESPRSKGGRDHKGVHSGLSTHLHRPRPPGGATERAGQSRVRPHIPAGLRAAGQEVGPSPIGPLERRGGAKSQSPCPAPPKSRPRLWAPPSSGWPSHSGKPLSSPAPALTVIQTQYFHSSKREEGPEETASRGAKDFTQPRAFSTFLGSLTLFGDWEPLQWFKIPDTPWPRPLASVHAPTTPTPFFFSWPAPRPPRSSLNSGCLPHPAAPNTCHSLPCSAIWRQGPPILASGARALPTPILTLPRGSRALQPGVGRGQWLQPGPKSNVLAGAIFFFFFFLIRSLTLSPRLKCSGAISAHCKLRLLDSRHSPASASRVAGTTGARHHAQLIFFGIFSRDGVSPLARMVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R287</accession>
    <name>A0A8I5R287_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Shroom family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SHROOM3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000069670.1">
        <property type="protein sequence ID" value="ENSPANP00000058634.1"/>
        <property type="gene ID" value="ENSPANG00000023419.4"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157778"/>
    <dbReference type="OMA" id="PFCKERS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06750">
        <property type="entry name" value="PDZ_shroom2_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000100">
        <property type="entry name" value="Shroom family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014800">
        <property type="entry name" value="ASD1_dom"/>
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    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF33">
        <property type="entry name" value="PROTEIN SHROOM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08688">
        <property type="entry name" value="ASD1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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            <begin position="25"/>
            <end position="110"/>
        </location>
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    <feature type="domain" description="ASD1" evidence="12">
        <location>
            <begin position="928"/>
            <end position="1030"/>
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            <begin position="1675"/>
            <end position="1963"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1409"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1504"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1644"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1657"/>
            <end position="1669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2002" mass="217887" checksum="0D1EC4730A3C22F1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R4X2</accession>
    <name>A0A8I5R4X2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R4X2"/>
    <dbReference type="Ensembl" id="ENSPANT00000074435.1">
        <property type="protein sequence ID" value="ENSPANP00000047907.1"/>
        <property type="gene ID" value="ENSPANG00000037158.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="181" mass="20344" checksum="38E3A4E3FDECAA4F" modified="2022-05-25" version="1">MSRNHLCPMFLLQLAQDKKSTPTQALYAWCLRFLQTLFQLLEFFALSLFFCLFFVLFVLFCFVFLRQSLALSPRPEYNGAISAHYNFHLLGSSNSPASASQVAEIIGAHHHAWLIFVFLVETGFHHIGQAGLKLLTSGDPPPSASESVGITGMSHHAQFKELLRLNNKKPNNPILKMGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R7F6</accession>
    <name>A0A8I5R7F6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-dependent peroxide reductase, mitochondrial</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PRDX3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13. Interacts with RPS6KC1 (via PX domain).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003904375.1">
        <property type="nucleotide sequence ID" value="XM_003904326.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R7F6"/>
    <dbReference type="Ensembl" id="ENSPANT00000072913.1">
        <property type="protein sequence ID" value="ENSPANP00000053780.1"/>
        <property type="gene ID" value="ENSPANG00000048950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101023776"/>
    <dbReference type="KEGG" id="panu:101023776"/>
    <dbReference type="CTD" id="10935"/>
    <dbReference type="GeneTree" id="ENSGT00940000153430"/>
    <dbReference type="OMA" id="KDSKQYF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="63"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="256" mass="27791" checksum="1570BAD2AEA1E57F" modified="2022-05-25" version="1">MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSYHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGPGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPADWTPDSPTIKPNPAASKEYFQKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R912</accession>
    <name>A0A8I5R912_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat and SOCS box protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ASB8</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TBK1; this interaction promotes TBK1 proteasomal degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009178871.1">
        <property type="nucleotide sequence ID" value="XM_009180607.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178872.1">
        <property type="nucleotide sequence ID" value="XM_009180608.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178873.1">
        <property type="nucleotide sequence ID" value="XM_009180609.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178874.1">
        <property type="nucleotide sequence ID" value="XM_009180610.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178875.1">
        <property type="nucleotide sequence ID" value="XM_009180611.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178877.1">
        <property type="nucleotide sequence ID" value="XM_009180613.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021777953.1">
        <property type="nucleotide sequence ID" value="XM_021922261.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021777954.1">
        <property type="nucleotide sequence ID" value="XM_021922262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R912"/>
    <dbReference type="SMR" id="A0A8I5R912"/>
    <dbReference type="Ensembl" id="ENSPANT00000071595.1">
        <property type="protein sequence ID" value="ENSPANP00000057704.1"/>
        <property type="gene ID" value="ENSPANG00000047762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101000996"/>
    <dbReference type="KEGG" id="panu:101000996"/>
    <dbReference type="CTD" id="140461"/>
    <dbReference type="GeneTree" id="ENSGT00940000159366"/>
    <dbReference type="OMA" id="NCMHGIL"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03727">
        <property type="entry name" value="SOCS_ASB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000274">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000303">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037332">
        <property type="entry name" value="ASB8_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="13">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="288" mass="31642" checksum="B10FB7ADBDC3D3D6" modified="2022-05-25" version="1">MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0CM74</accession>
    <name>B0CM74_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Basic leucine zipper transcriptional factor ATF-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">BATF2</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2008-01" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer; heterodimerizes with JUN family proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000551">
        <property type="protein sequence ID" value="ABY63647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162477.1">
        <property type="nucleotide sequence ID" value="NM_001169006.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017803585.1">
        <property type="nucleotide sequence ID" value="XM_017948096.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017803586.1">
        <property type="nucleotide sequence ID" value="XM_017948097.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0CM74"/>
    <dbReference type="STRING" id="9555.ENSPANP00000046313"/>
    <dbReference type="Ensembl" id="ENSPANT00000078403.1">
        <property type="protein sequence ID" value="ENSPANP00000048953.1"/>
        <property type="gene ID" value="ENSPANG00000032555.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100137477"/>
    <dbReference type="KEGG" id="panu:100137477"/>
    <dbReference type="CTD" id="116071"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162373"/>
    <dbReference type="HOGENOM" id="CLU_088611_0_0_1"/>
    <dbReference type="OMA" id="HGCQEQP"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032555">
        <property type="expression patterns" value="Expressed in ascending colon and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043011">
        <property type="term" value="P:myeloid dendritic cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14701">
        <property type="entry name" value="bZIP_BATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000080">
        <property type="entry name" value="Basic leucine zipper transcriptional factor ATF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF11">
        <property type="entry name" value="BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABY63647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="308" mass="32335" checksum="E8019F94C26F06F2" modified="2008-02-26" version="1">MHLCRGNGLLTGTDPEEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALRKEIQALQAELAWWSQTLHVHERLCPMDCASCSAAGLPGCWDQAEGLLGPGPQGQHGCQEQLELFQTPDSCSPAQPLSPGPQPHDSPSLLQSPLPSLSLGPTVVAEPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLKSSPNNPSSDLGLACLQSREHKPALSAAAWQGLGVDPSPHPLLAFPLLASLKSTSNLVSGAALAPSSGSGSNLSTRASPPSLLGAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKN1</accession>
    <name>A0A096MKN1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PGK2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="19"/>
    <dbReference type="RefSeq" id="XP_003897770.1">
        <property type="nucleotide sequence ID" value="XM_003897721.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A096MKN1"/>
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    <dbReference type="Ensembl" id="ENSPANT00000002993.3">
        <property type="protein sequence ID" value="ENSPANP00000000047.1"/>
        <property type="gene ID" value="ENSPANG00000003184.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022427"/>
    <dbReference type="KEGG" id="panu:101022427"/>
    <dbReference type="CTD" id="5232"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000008820"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OMA" id="GPETNKK"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003184">
        <property type="expression patterns" value="Expressed in testis"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:extracellular exosome"/>
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    <dbReference type="GO" id="GO:0035686">
        <property type="term" value="C:sperm fibrous sheath"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:gluconeogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
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    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
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    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
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    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
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    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
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        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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            <begin position="63"/>
            <end position="66"/>
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            <name>substrate</name>
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            <position position="123"/>
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    </feature>
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        <location>
            <position position="171"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <name>ATP</name>
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            <end position="376"/>
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            <name>ATP</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023152"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="417" mass="44879" checksum="6974DB4249448E48" modified="2014-11-26" version="1">MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVLMSHLGRPDGVPMPDKYSLQPVAAELKSLLGKDILFLKDCVGAEVENACANPAPGSVILLENLRFHVEEEGKGQDPSGKKIKAEPDKIEGFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGMAYTFLKVLNNMEIGASLFDEEGAKIVKDIMTKAQKNGVRITFPVDFVTADKFDENAQVGKATVASGIPPGWMGLDCGPESNKNHAQVVAQARLIVWNGPLGVFEWDAFAKGTKALMDEIVKATSKGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKILPGVEALSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MM71</accession>
    <name>A0A096MM71_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L23, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MM71"/>
    <dbReference type="Ensembl" id="ENSPANT00000000369.3">
        <property type="protein sequence ID" value="ENSPANP00000000694.2"/>
        <property type="gene ID" value="ENSPANG00000018813.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007739"/>
    <dbReference type="HOGENOM" id="CLU_103097_1_0_1"/>
    <dbReference type="OMA" id="PNFWLKL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018813">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MM71">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000284">
        <property type="entry name" value="39S ribosomal protein L23, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000694.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="153" mass="17777" checksum="C2230E6A952541BB" modified="2022-05-25" version="2">VARNVVYPLYQLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLESIYNVPVAAVRTRVQYGSNKRRDHRNVRIKKPDYKVAYVQLAHGQTFTFPDLFPEKDQSPEGSTADGLHDMLTEERRQRQSSDPRRGGVPNWFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNE9</accession>
    <name>A0A096MNE9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synaptonemal complex central element protein 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SYCE1L</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SYCE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917255.1">
        <property type="nucleotide sequence ID" value="XM_003917206.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNE9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001175"/>
    <dbReference type="Ensembl" id="ENSPANT00000026885.3">
        <property type="protein sequence ID" value="ENSPANP00000001175.2"/>
        <property type="gene ID" value="ENSPANG00000018343.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022458"/>
    <dbReference type="KEGG" id="panu:101022458"/>
    <dbReference type="CTD" id="100130958"/>
    <dbReference type="eggNOG" id="ENOG502QZY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017352"/>
    <dbReference type="HOGENOM" id="CLU_068366_1_0_1"/>
    <dbReference type="OMA" id="QLHCQRK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018343">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026676">
        <property type="entry name" value="SYCE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21731">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21731:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15233">
        <property type="entry name" value="SYCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001175.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="242" mass="27323" checksum="3199FAC0C99A7366" modified="2018-02-28" version="2">MAGKLKPLNVEAPEAAEEAEGQAKSLKTEDLLAMVIKLQKEGSLEPQIEDLINRINELQQAKKKSSEELRETHTLWEALHRELDSLNGEKVHLEEVLSKKQEALRILQMHCQEKESEARRLDVKGQLEDLTGQHKDLWEFHMLEQRLAREIRALERSKEQLLSERRLVRAKLRDVERRLSSPPEVEGARAVNDGLKAELEIFAEQVPSAPEVGAGEGEAGRELPRARDEADPEPPVAAPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNK2</accession>
    <name>A0A096MNK2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Otogelin like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OTOGL</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the otogelin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_021922642.2"/>
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        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
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        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
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        <property type="entry name" value="OTOGL-like_N"/>
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        <property type="entry name" value="Ser_inhib-like_sf"/>
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        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
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        <property type="entry name" value="VWF_type-D"/>
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        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
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    <dbReference type="PANTHER" id="PTHR11339:SF225">
        <property type="entry name" value="OTOGELIN-LIKE PROTEIN"/>
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        <property type="entry name" value="CT"/>
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        <property type="entry name" value="VWC_out"/>
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        <property type="entry name" value="AbfB domain"/>
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        <property type="entry name" value="Serine protease inhibitors"/>
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        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5035254247" evidence="8">
        <location>
            <begin position="32"/>
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        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
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            <begin position="121"/>
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    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
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    <feature type="domain" description="VWFD" evidence="10">
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    <feature type="domain" description="VWFD" evidence="10">
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    </feature>
    <feature type="domain" description="CTCK" evidence="9">
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="2353" mass="264685" checksum="E31E330492010F84" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQQ5</accession>
    <name>A0A096MQQ5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YIF1A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909578.1">
        <property type="nucleotide sequence ID" value="XM_003909529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQQ5"/>
    <dbReference type="Ensembl" id="ENSPANT00000026784.3">
        <property type="protein sequence ID" value="ENSPANP00000002089.1"/>
        <property type="gene ID" value="ENSPANG00000023600.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002177"/>
    <dbReference type="KEGG" id="panu:101002177"/>
    <dbReference type="CTD" id="10897"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009423"/>
    <dbReference type="HOGENOM" id="CLU_047877_1_1_1"/>
    <dbReference type="OMA" id="NWEVRYS"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023600">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQQ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF2">
        <property type="entry name" value="PROTEIN YIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="293" mass="32078" checksum="7CDAC589E3923A69" modified="2014-11-26" version="1">MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPAPGADVAFSVNHLLGDPMANVAMAYGSSIASHGKDLVHKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDVPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGLYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSFRTAALGPDSMGGPVPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MT75</accession>
    <name>A0A096MT75_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibroblast growth factor</fullName>
            <shortName evidence="3">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FGF16</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917954.1">
        <property type="nucleotide sequence ID" value="XM_003917905.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MT75"/>
    <dbReference type="SMR" id="A0A096MT75"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002999"/>
    <dbReference type="Ensembl" id="ENSPANT00000022631.3">
        <property type="protein sequence ID" value="ENSPANP00000002999.2"/>
        <property type="gene ID" value="ENSPANG00000002965.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012136"/>
    <dbReference type="KEGG" id="panu:101012136"/>
    <dbReference type="CTD" id="8823"/>
    <dbReference type="eggNOG" id="KOG3885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160087"/>
    <dbReference type="HOGENOM" id="CLU_1975570_0_0_1"/>
    <dbReference type="OMA" id="MDSERHY"/>
    <dbReference type="OrthoDB" id="6158176at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002965">
        <property type="expression patterns" value="Expressed in white adipose tissue and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000546">
        <property type="term" value="P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23326">
        <property type="entry name" value="beta-trefoil_FGF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000004">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0339">Growth factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002999.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="207" mass="23759" checksum="D8AD160BDABDB5F8" modified="2018-02-28" version="2">MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVE9</accession>
    <name>A0A096MVE9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC14</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_017813682.1">
        <property type="nucleotide sequence ID" value="XM_017958193.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MVE9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003824"/>
    <dbReference type="Ensembl" id="ENSPANT00000027150.3">
        <property type="protein sequence ID" value="ENSPANP00000003824.2"/>
        <property type="gene ID" value="ENSPANG00000007490.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026773"/>
    <dbReference type="KEGG" id="panu:101026773"/>
    <dbReference type="CTD" id="79683"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156483"/>
    <dbReference type="HOGENOM" id="CLU_018741_0_0_1"/>
    <dbReference type="OMA" id="TSDEMHL"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007490">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF28">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="163"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003824.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="488" mass="53361" checksum="A9DD09EA5FE2F135" modified="2018-02-28" version="2">MPPGGGGPMKDCEYSQISTHSSSPMESPHKKKKIAARRKWEVFPGRNKFFCNGRIMMARQTGVFYLTLVLILVTSGLFFAFDCPYLAVKITPAIPAVAGILFFFVMGTLLRTSFSDPGVLPRATPDEAADLERQIDIANGTSSGGYRPPPRTKEVIINGQTVKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIFAFVITHVILRSQQTGFLNALKDSPASVLEAVVCFFSVWSIVGLSGFHTYLISSNQTTNEDIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSSGITMYGATQSQSDMCDQDQCIQSTKFVLQAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDEAPSPPRLLAAGSPLAHSRTMHVLGLASQDSLHEDSVRGLVKLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0L4</accession>
    <name>A0A096N0L4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RNMT</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031514517.1">
        <property type="nucleotide sequence ID" value="XM_031658657.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031514518.1">
        <property type="nucleotide sequence ID" value="XM_031658658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0L4"/>
    <dbReference type="SMR" id="A0A096N0L4"/>
    <dbReference type="Ensembl" id="ENSPANT00000018311.4">
        <property type="protein sequence ID" value="ENSPANP00000005801.2"/>
        <property type="gene ID" value="ENSPANG00000010248.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101005360"/>
    <dbReference type="CTD" id="8731"/>
    <dbReference type="GeneTree" id="ENSGT00390000002368"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010248">
        <property type="expression patterns" value="Expressed in thyroid gland and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0L4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
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    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11 13" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="15">
        <location>
            <begin position="167"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="68"/>
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    </feature>
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            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005801.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="476" mass="54987" checksum="36E795F64364CD79" modified="2022-05-25" version="2">MANSTKAEEYEKMSLEQAKASMNSETESSFGINENTTASGTGLSEKTSVCRQVDTARKRKEFEDDLVKESSSCGEDTLSKKRKLDPEIVPEEKDCGDDEGNSKKRKRETEDVPKDEYSTGDGAQNKRKIVLEDVPEKQKNLEEGHSSAVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSIKQCQQRYEDMKNRRDSEYIFSAEFITADCSKELLIEKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSERVDDYEHAAKYMKNSQVKLPLGTLSKSEWEATSIYLVFAFEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1X4</accession>
    <name>A0A096N1X4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acrosin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acrosin-binding protein, 60 kDa form</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Proacrosin-binding protein sp32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ACRBP</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003905909.2">
        <property type="nucleotide sequence ID" value="XM_003905860.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1X4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006315"/>
    <dbReference type="Ensembl" id="ENSPANT00000001090.3">
        <property type="protein sequence ID" value="ENSPANP00000006315.3"/>
        <property type="gene ID" value="ENSPANG00000017796.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019777"/>
    <dbReference type="KEGG" id="panu:101019777"/>
    <dbReference type="CTD" id="84519"/>
    <dbReference type="eggNOG" id="ENOG502R6TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000826"/>
    <dbReference type="HOGENOM" id="CLU_534141_0_0_1"/>
    <dbReference type="OMA" id="YDEEPVW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017796">
        <property type="expression patterns" value="Expressed in testis and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1X4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009865">
        <property type="entry name" value="Proacrosin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362:SF1">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07222">
        <property type="entry name" value="PBP_sp32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035148743" description="Acrosin-binding protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A096N2M8</accession>
    <name>A0A096N2M8_PAPAN</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
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                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A096N3P4"/>
    <dbReference type="Ensembl" id="ENSPANT00000013969.3">
        <property type="protein sequence ID" value="ENSPANP00000006974.3"/>
        <property type="gene ID" value="ENSPANG00000023743.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183133"/>
    <dbReference type="HOGENOM" id="CLU_060336_0_0_1"/>
    <dbReference type="OMA" id="LPAYCML"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029269">
        <property type="expression patterns" value="Expressed in metanephros cortex and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047946">
        <property type="term" value="F:glutamine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000090">
        <property type="entry name" value="Glycine N-acyltransferase-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013652">
        <property type="entry name" value="Glycine_N-acyltransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015938">
        <property type="entry name" value="Glycine_N-acyltransferase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF7">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08444">
        <property type="entry name" value="Gly_acyl_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06021">
        <property type="entry name" value="Gly_acyl_tr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycine N-acyltransferase N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine N-acyltransferase C-terminal" evidence="6">
        <location>
            <begin position="208"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006974.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="302" mass="35137" checksum="035080B2664E7D86" modified="2022-05-25" version="3">MILLNNSHKLLALYKSLARSIPESLKVYGSVYHINHGNPFNMEVLVDSWPEYQMVIIRPQKQEMTDDMDSYTNVYHMFSKEPQKSQEVLKNCEIINWKQRFQIQGLQESLGEGIRAAAFSKSVKVEHSTAVLLVTEDTLKLNASSESKFGSWAETGHPDDDFESETPNFKYAQLAVSYSGLVNDNWKRGRNERSLRFIKRCIQDLPAACMLGPEGVPVSWVTMDPSCEVGMAYSMEKYRRTGNMARVMVRYMKYLRQKNIPFYLSVREENEYSRRFVQQLGFFEASCEWHQWICYPQNLVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N784</accession>
    <name>A0A096N784_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cholecystokinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCK</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the gastrin/cholecystokinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021790216.1">
        <property type="nucleotide sequence ID" value="XM_021934524.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N784"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008379"/>
    <dbReference type="Ensembl" id="ENSPANT00000017356.3">
        <property type="protein sequence ID" value="ENSPANP00000008379.1"/>
        <property type="gene ID" value="ENSPANG00000012767.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011493"/>
    <dbReference type="KEGG" id="panu:101011493"/>
    <dbReference type="CTD" id="885"/>
    <dbReference type="eggNOG" id="ENOG502S472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003571"/>
    <dbReference type="HOGENOM" id="CLU_169783_0_0_1"/>
    <dbReference type="OMA" id="YSGLCIC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012767">
        <property type="expression patterns" value="Expressed in amygdala and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051428">
        <property type="term" value="F:peptide hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038188">
        <property type="term" value="P:cholecystokinin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042755">
        <property type="term" value="P:eating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015499">
        <property type="entry name" value="CCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001651">
        <property type="entry name" value="Gastrin/CCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013152">
        <property type="entry name" value="Gastrin/cholecystokinin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10786">
        <property type="entry name" value="CHOLECYSTOKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10786:SF0">
        <property type="entry name" value="CHOLECYSTOKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00918">
        <property type="entry name" value="Gastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00029">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00259">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001927985" evidence="9">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Gastrin/cholecystokinin peptide hormone" evidence="10">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="115" mass="12734" checksum="B78ADA815A98000D" modified="2014-11-26" version="1">MNSGVRLCVLMAVLAAGALTQPVPPAEPAGSGLQRAEEAPRRQLRAVQRTDGESRAHLGALLARYIQQARKAPSGRMSIIKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7K3</accession>
    <name>A0A096N7K3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Synaptotagmin-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptotagmin VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SYT8</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca(2+). Interacts with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5-tetrakisphosphate (IP4). Binds to AP2 in a Ca(2+)-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N7K3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008541"/>
    <dbReference type="Ensembl" id="ENSPANT00000000355.3">
        <property type="protein sequence ID" value="ENSPANP00000008541.3"/>
        <property type="gene ID" value="ENSPANG00000007903.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160892"/>
    <dbReference type="HOGENOM" id="CLU_023008_0_1_1"/>
    <dbReference type="OMA" id="ECWYQLG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007903">
        <property type="expression patterns" value="Expressed in cornea and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000176">
        <property type="entry name" value="Synaptotagmin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000182">
        <property type="entry name" value="Synaptotagmin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF249">
        <property type="entry name" value="SYNAPTOTAGMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="135"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="263"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008541.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="419" mass="45683" checksum="9C2AEE9C59A89223" modified="2022-05-25" version="3">MGHPPDSPSALAPAGTTAIPGLIPDLIAGTPCELWDSQEGCGDNPAKWGLQLSIYALSPASTPGPRWALIAGALAAGVLVVSCLLCTACCCCRRHRKKPRDKEAVGLGSARGTTTTHLVQPDVDSLESSPGGAQQWGRLQLSLEYDFGSQEIRVGLRQAADLRPGGTVDPYARVSVSTQSGHRHETKVHRGTLCPVFDETCCFHILQAELPGTTLQVQLFNFKHFSGHEPLGELCLPLGTVDLQHVLEHWYPLGPPAATEPEQVGELCFSLRYVPSSGRLTVVVLEARGLHPGLAEPYVKVQLMLNQRKWKKRKTATRKGTAAPYFNEAFTFLVPFSQVQNVDLVLAVWDRGLLLRAEPVGKVHLGARASGQPLQHWADMLAHARRPIAQWHPLQPAREVDHVLALQPRLRLHLPLPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8Y0</accession>
    <name>A0A096N8Y0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CYP4A22</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N8Y0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009061"/>
    <dbReference type="Ensembl" id="ENSPANT00000023049.3">
        <property type="protein sequence ID" value="ENSPANP00000009061.3"/>
        <property type="gene ID" value="ENSPANG00000039694.1"/>
    </dbReference>
    <dbReference type="VGNC" id="VGNC:82577">
        <property type="gene designation" value="CYP4A22"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163504"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_1"/>
    <dbReference type="OMA" id="ASITWHH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004653">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008391">
        <property type="term" value="F:arachidonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046456">
        <property type="term" value="P:icosanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048252">
        <property type="term" value="P:lauric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF39">
        <property type="entry name" value="CYTOCHROME P450 4A11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009061.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="VGNC" id="VGNC:82577"/>
        </source>
    </evidence>
    <sequence length="508" mass="57629" checksum="4C44A3860C0AB6BB" modified="2022-05-25" version="3">MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWFFGHFQKVGRNSMGEPQRNTQPTSLVSACPSHDELTRPMKRILLVLSSITHALLLQISRYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVALMADSVRVMLDKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSYQGSIQVDRNSQSYIQAISDLNNLTFSRVRNAFHQNDTIYSLTSTGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRNPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9Y4</accession>
    <name>A0A096N9Y4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leukocyte cell-derived chemotaxin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LECT2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the LECT2/MIM-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N9Y4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009475"/>
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        <property type="protein sequence ID" value="ENSPANP00000009475.2"/>
        <property type="gene ID" value="ENSPANG00000019400.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019400">
        <property type="expression patterns" value="Expressed in liver and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N9Y4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.70.10:FF:000011">
        <property type="entry name" value="Leukocyte cell-derived chemotaxin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008663">
        <property type="entry name" value="LECT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017381">
        <property type="entry name" value="LECT2_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="M23ase_b-sheet_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11329">
        <property type="entry name" value="LEUKOCYTE CELL-DERIVED CHEMOTAXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11329:SF0">
        <property type="entry name" value="LEUKOCYTE CELL-DERIVED CHEMOTAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038085">
        <property type="entry name" value="LECT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158554" description="Leukocyte cell-derived chemotaxin-2" evidence="9">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="M23ase beta-sheet core" evidence="10">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009475.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="150" mass="16332" checksum="D09A1EF29E1D7C52" modified="2022-05-25" version="2">MFSTKVLLLAGLISTALAGPWANICAGKSSNEIRMCDRHGCGQYSARSQRPHQGVDILCSAGSTVYAPFTGMIVGQEKPYQNKNAINNGVRISGRGFCVKMFYIKPIKYKGPVKKGEKLGTLLPLQKVYPGIQSHVHIENCDLSDPTAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA15</accession>
    <name>A0A096NA15_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NA15"/>
    <dbReference type="Ensembl" id="ENSPANT00000015209.3">
        <property type="protein sequence ID" value="ENSPANP00000009509.3"/>
        <property type="gene ID" value="ENSPANG00000050841.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183010"/>
    <dbReference type="HOGENOM" id="CLU_083987_0_1_1"/>
    <dbReference type="OMA" id="IKRMHIR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014205">
        <property type="expression patterns" value="Expressed in esophagus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NA15">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
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    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009509.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="158" mass="18317" checksum="924560D91DF483BA" modified="2022-05-25" version="3">PSYLGGSNLRVHFKNTRETAQAIKGMHIRKCIPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCE9</accession>
    <name>A0A096NCE9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chemerin-like receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chemerin chemokine-like receptor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Chemokine-like receptor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">G-protein coupled receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CMKLR2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
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                <person name="Bickham C.B."/>
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                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
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                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
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                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
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                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
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        <property type="entry name" value="CML2"/>
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        <property type="entry name" value="Formyl_rcpt-rel"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF74">
        <property type="entry name" value="CHEMOKINE-LIKE RECEPTOR 1"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="GPR1ORPHANR"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="74"/>
            <end position="94"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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        <location>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="55"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00030357"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="ARBA" id="ARBA00031086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="355" mass="41349" checksum="A159EC63F679E54A" modified="2014-11-26" version="1">MEDVEETLFEEFENYSYALDYYSLESDLEEKVQLGVVHWVSLVLYCLSFVLGIPGNAIVIWFMGFKWKKTVSTLWFLNLAIADFIFLLFLPLYISYVVMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTVIRHHVLTWVKFIVGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILAVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFQSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEC3</accession>
    <name>A0A096NEC3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein misato homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MSTO1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NEC3"/>
    <dbReference type="Ensembl" id="ENSPANT00000028639.3">
        <property type="protein sequence ID" value="ENSPANP00000011240.3"/>
        <property type="gene ID" value="ENSPANG00000006654.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064067"/>
    <dbReference type="HOGENOM" id="CLU_022511_0_0_1"/>
    <dbReference type="OMA" id="FVGSHIW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006654">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048311">
        <property type="term" value="P:mitochondrion distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010636">
        <property type="term" value="P:positive regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="157"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011240.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="514" mass="55669" checksum="AFC12EF9B5FD270C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFF3</accession>
    <name>A0A096NFF3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat and SOCS box protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ASB15</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NFF3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011649"/>
    <dbReference type="Ensembl" id="ENSPANT00000024461.3">
        <property type="protein sequence ID" value="ENSPANP00000011649.1"/>
        <property type="gene ID" value="ENSPANG00000000491.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157073"/>
    <dbReference type="HOGENOM" id="CLU_023739_1_0_1"/>
    <dbReference type="OMA" id="HVNDTHF"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000491">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03731">
        <property type="entry name" value="SOCS_ASB15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000310">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000460">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF187">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="539"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="594" mass="66555" checksum="EE5C64C2DD775A69" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NG15</accession>
    <name>A0A096NG15_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Ataxia telangiectasia and Rad3-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">ATR</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031519570.1">
        <property type="nucleotide sequence ID" value="XM_031663710.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000011874"/>
    <dbReference type="Ensembl" id="ENSPANT00000005465.3">
        <property type="protein sequence ID" value="ENSPANP00000011874.3"/>
        <property type="gene ID" value="ENSPANG00000005574.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017442"/>
    <dbReference type="KEGG" id="panu:101017442"/>
    <dbReference type="CTD" id="545"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155714"/>
    <dbReference type="HOGENOM" id="CLU_000178_2_1_1"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005574">
        <property type="expression patterns" value="Expressed in axillary lymph node and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NG15">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070310">
        <property type="term" value="C:ATR-ATRIP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035979">
        <property type="term" value="F:histone H2AXS139 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032405">
        <property type="term" value="F:MutLalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032407">
        <property type="term" value="F:MutSalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071480">
        <property type="term" value="P:cellular response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097694">
        <property type="term" value="P:establishment of RNA localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051081">
        <property type="term" value="P:nuclear membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043517">
        <property type="term" value="P:positive regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904884">
        <property type="term" value="P:positive regulation of telomerase catalytic core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070198">
        <property type="term" value="P:protein localization to chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090399">
        <property type="term" value="P:replicative senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000009">
        <property type="entry name" value="Putative serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000149">
        <property type="entry name" value="Serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000142">
        <property type="entry name" value="Serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000011">
        <property type="entry name" value="serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056803">
        <property type="entry name" value="ATR-like_N-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25032">
        <property type="entry name" value="N-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PI3_4_KINASE_2"/>
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    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="HEAT" evidence="23">
        <location>
            <begin position="805"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="26">
        <location>
            <begin position="1640"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="25">
        <location>
            <begin position="2296"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="27">
        <location>
            <begin position="2612"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="418"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00084048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011874.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2644" mass="301283" checksum="CD690E5495789286" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIM1</accession>
    <name>A0A096NIM1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NF-kappa-B inhibitor epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">I-kappa-B-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NFKBIE</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Interacts with HNRNPA2B1; the interaction may be mediated by the RRM2 domain of HNRNPA2B1, and HNRNPA2B1 may interact simultaneously with FAM76B and either NFKBIA or NFKBIE to form a complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NF-kappa-B inhibitor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897721.3">
        <property type="nucleotide sequence ID" value="XM_003897672.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NIM1"/>
    <dbReference type="SMR" id="A0A096NIM1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012819"/>
    <dbReference type="Ensembl" id="ENSPANT00000016596.3">
        <property type="protein sequence ID" value="ENSPANP00000012819.3"/>
        <property type="gene ID" value="ENSPANG00000022206.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001861"/>
    <dbReference type="KEGG" id="panu:101001861"/>
    <dbReference type="CTD" id="4794"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159120"/>
    <dbReference type="HOGENOM" id="CLU_000134_6_2_1"/>
    <dbReference type="OMA" id="PMFNGCT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022206">
        <property type="expression patterns" value="Expressed in amygdala and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NF-kappa-B inhibitor epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF5">
        <property type="entry name" value="NFKB INHIBITOR EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="297"/>
            <end position="329"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="104"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="45"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="70"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="87"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012819.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="361" mass="38394" checksum="EEA287632A8BB502" modified="2022-05-25" version="3">MSEARKGPDEADESQYDSGIESLRSLRSLPEPTSAPASGPSDGSPQPCTHPPGPAKEPQQKEDADGERADSTYGSSSLTESLSLLGGPEAEDPAPRPPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLQNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIQ9</accession>
    <name>A0A096NIQ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">ADP-ribosylation factor-like protein 2-binding protein</fullName>
            <shortName evidence="14">ARF-like 2-binding protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ARL2BP</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
            <location evidence="1 14">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
            <location evidence="4 14">Cytoskeleton</location>
            <location evidence="4 14">Microtubule organizing center</location>
            <location evidence="4 14">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the ARL2BP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003916980.1">
        <property type="nucleotide sequence ID" value="XM_003916931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NIQ9"/>
    <dbReference type="SMR" id="A0A096NIQ9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012857"/>
    <dbReference type="Ensembl" id="ENSPANT00000008152.3">
        <property type="protein sequence ID" value="ENSPANP00000012857.1"/>
        <property type="gene ID" value="ENSPANG00000018652.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003383"/>
    <dbReference type="KEGG" id="panu:101003383"/>
    <dbReference type="CTD" id="23568"/>
    <dbReference type="eggNOG" id="ENOG502RYJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015052"/>
    <dbReference type="HOGENOM" id="CLU_116781_0_0_1"/>
    <dbReference type="OMA" id="CILEIIM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018652">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NIQ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1520.10:FF:000002">
        <property type="entry name" value="ADP-ribosylation factor-like protein 2-binding protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038849">
        <property type="entry name" value="ARL2BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 14" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="15">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="163" mass="18786" checksum="DB64EF0DB6F99305" modified="2014-11-26" version="1">MDALEEESFALSFSSASDAEFDAVVGYLEDIIMDDEFQLLQRNFMDKYYLEFEDTEENKLTYTPIFNEYISLVEKYIEEQLLQRIPGFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSVSASQNNLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNR5</accession>
    <name>A0A096NNR5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 23">Prostacyclin synthase</fullName>
            <ecNumber evidence="23">5.3.99.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Prostaglandin I2 synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 29" type="primary">PTGIS</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE).</text>
    </comment>
    <comment type="function">
        <text evidence="23">Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>prostaglandin H2 = prostaglandin I2</text>
            <dbReference type="Rhea" id="RHEA:23580"/>
            <dbReference type="ChEBI" id="CHEBI:57403"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="EC" id="5.3.99.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:23581"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 23 24">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 23">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.4" evidence="23"/>
    <dbReference type="RefSeq" id="XP_031512697.1">
        <property type="nucleotide sequence ID" value="XM_031656837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNR5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014625"/>
    <dbReference type="Ensembl" id="ENSPANT00000024860.3">
        <property type="protein sequence ID" value="ENSPANP00000014625.3"/>
        <property type="gene ID" value="ENSPANG00000007535.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101015498"/>
    <dbReference type="KEGG" id="panu:101015498"/>
    <dbReference type="CTD" id="5740"/>
    <dbReference type="VGNC" id="VGNC:82579">
        <property type="gene designation" value="PTGIS"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153709"/>
    <dbReference type="OMA" id="KFITRMK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007535">
        <property type="expression patterns" value="Expressed in aorta and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008116">
        <property type="term" value="F:prostaglandin-I synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071354">
        <property type="term" value="P:cellular response to interleukin-6"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046697">
        <property type="term" value="P:decidualization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045019">
        <property type="term" value="P:negative regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035360">
        <property type="term" value="P:positive regulation of peroxisome proliferator activated receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20634">
        <property type="entry name" value="PGIS_CYP8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000025">
        <property type="entry name" value="Prostaglandin I2 (prostacyclin) synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024204">
        <property type="entry name" value="Cyt_P450_CYP7A1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027286">
        <property type="entry name" value="PTGIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF4">
        <property type="entry name" value="PROSTACYCLIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000047">
        <property type="entry name" value="Cytochrome_CYPVIIA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500628">
        <property type="entry name" value="PTGIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 23" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="19 23" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10 23 24" id="KW-0349">Heme</keyword>
    <keyword evidence="16 23 24" id="KW-0408">Iron</keyword>
    <keyword evidence="20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-0456">Lyase</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 23" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="7 23" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="26" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315315" description="Prostacyclin synthase" evidence="26">
        <location>
            <begin position="25"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="24">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000047-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000047-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014625.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="VGNC" id="VGNC:82579"/>
        </source>
    </evidence>
    <sequence length="500" mass="57009" checksum="F07B82567FA7B7DD" modified="2022-05-25" version="3">MTWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWESRTRLDFHAYAVFLMERIFDVQLPHYSPSDEKARMKPTLLHRELQALTEAMYTNLHTVLLGDATEAGSGWHEMGLLDFSYSSLLRAGYLTLYGIEALPRTHQSQAQDRIHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWEAEQPVSQMTTLPQKVLDGTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGKSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPIRYRIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ56</accession>
    <name>A0A096NQ56_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Costars family protein ABRACL</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ABRA C-terminal-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the costars family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQ56"/>
    <dbReference type="SMR" id="A0A096NQ56"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015150"/>
    <dbReference type="Ensembl" id="ENSPANT00000024265.3">
        <property type="protein sequence ID" value="ENSPANP00000015150.2"/>
        <property type="gene ID" value="ENSPANG00000017771.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00470000042287"/>
    <dbReference type="HOGENOM" id="CLU_173478_0_0_1"/>
    <dbReference type="OMA" id="QCTEGTR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017771">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032970">
        <property type="term" value="P:regulation of actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044302">
        <property type="entry name" value="Costars"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334:SF1">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="4">
        <location>
            <begin position="151"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015150.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="231" mass="25286" checksum="4C8444312EA53DDA" modified="2025-10-08" version="3">MPSAIRGRFVSYVGREILQEIDAQDQLQILGSLALSSTVEKWGNRGSGPVFLGAQGAPPVWSQLLSWTSPPLSFLLIGLSLGVWAAPFLSAETLTFPPTLLLLLHSRLSLCLSHFLSWPHPPQCTEEGNRVRTHAAPVLPREGKPGREAAMNVDHEVNLLVEEIHRLGSKNADGKLSVKFGVLFRDDKCANLFEALVGTLKAAKRRKIVTYSGELLLQGVHDDVDIVLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ85</accession>
    <name>A0A096NQ85_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein 4</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-keto acyl-CoA synthase ELOVL4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">ELOVL fatty acid elongase 4</fullName>
            <shortName evidence="10">ELOVL FA elongase 4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Very long chain 3-ketoacyl-CoA synthase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Very long chain 3-oxoacyl-CoA synthase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">ELOVL4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal di-lysine motif may confer endoplasmic reticulum localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family. ELOVL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003897886.3">
        <property type="nucleotide sequence ID" value="XM_003897837.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQ85"/>
    <dbReference type="SMR" id="A0A096NQ85"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015179"/>
    <dbReference type="Ensembl" id="ENSPANT00000029029.3">
        <property type="protein sequence ID" value="ENSPANP00000015179.2"/>
        <property type="gene ID" value="ENSPANG00000018200.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000813"/>
    <dbReference type="KEGG" id="panu:101000813"/>
    <dbReference type="CTD" id="6785"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244838"/>
    <dbReference type="HOGENOM" id="CLU_048483_0_1_1"/>
    <dbReference type="OMA" id="WTYFTST"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018200">
        <property type="expression patterns" value="Expressed in zone of skin and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03204">
        <property type="entry name" value="VLCF_elongase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033678">
        <property type="entry name" value="ELOVL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
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            <begin position="45"/>
            <end position="63"/>
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        <location>
            <begin position="189"/>
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    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="220"/>
            <end position="240"/>
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        <location>
            <begin position="246"/>
            <end position="267"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="274"/>
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    <feature type="short sequence motif" description="Di-lysine motif" evidence="10">
        <location>
            <begin position="310"/>
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    <sequence length="314" mass="36812" checksum="560FE00C91D96766" modified="2018-02-28" version="2">MGLLDSEPGSVLNVVSTALNDTVEFYRWTWSIADKRVENWPLMQSPWPTLSISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNFFIFRELFMGSYNAGYSYICQSVDYSNNVNEVRIAAALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQAFFGAQMNSFIHVIMYSYYGLAAFGPWIQKYLWWKRYLTMLQLVQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYIRTYKEPKKPKTGKTAMNGISANGVSKSEKQLVIENGKKQKNGKAKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQI7</accession>
    <accession>A0A2I3MTR9</accession>
    <name>A0A096NQI7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="14">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">WASF1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Also involved in the regulation of mitochondrial dynamics.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus). Interacts with SORBS2; this interaction greatly enhances phosphorylation by ABL1 and dephosphorylation by PTPN12 and might mediate partial to focal adhesion sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SCAR/WAVE family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000015291.2"/>
        <property type="gene ID" value="ENSPANG00000007144.3"/>
    </dbReference>
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        <property type="gene ID" value="ENSPANG00000007144.3"/>
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    <dbReference type="Ensembl" id="ENSPANT00000080921.1">
        <property type="protein sequence ID" value="ENSPANP00000050933.1"/>
        <property type="gene ID" value="ENSPANG00000007144.3"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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    <keyword evidence="9 14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="WH2" evidence="16">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="170"/>
            <end position="202"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="412"/>
            <end position="490"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="182"/>
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            <begin position="322"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="15">
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        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015291.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="559" mass="61682" checksum="140E49C17BC6AC63" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQV7</accession>
    <name>A0A096NQV7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POU6F2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQV7"/>
    <dbReference type="Ensembl" id="ENSPANT00000016637.3">
        <property type="protein sequence ID" value="ENSPANP00000015421.1"/>
        <property type="gene ID" value="ENSPANG00000007998.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156175"/>
    <dbReference type="HOGENOM" id="CLU_013065_6_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007998">
        <property type="expression patterns" value="Expressed in urinary bladder and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQV7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF68">
        <property type="entry name" value="POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="472"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="601"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="603"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="93"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="293"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="687" mass="72746" checksum="E45F5E832CC67050" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NS51</accession>
    <name>A0A096NS51_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane p24 trafficking protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMED10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902115.1">
        <property type="nucleotide sequence ID" value="XM_003902066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NS51"/>
    <dbReference type="SMR" id="A0A096NS51"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015871"/>
    <dbReference type="Ensembl" id="ENSPANT00000007198.3">
        <property type="protein sequence ID" value="ENSPANP00000015871.1"/>
        <property type="gene ID" value="ENSPANG00000019635.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020229"/>
    <dbReference type="KEGG" id="panu:101020229"/>
    <dbReference type="CTD" id="10972"/>
    <dbReference type="eggNOG" id="KOG1691">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00550000074954"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_1_1"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019635">
        <property type="expression patterns" value="Expressed in pancreas and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042589">
        <property type="term" value="C:zymogen granule membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035964">
        <property type="term" value="P:COPI-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106273">
        <property type="term" value="P:cytosol to ERGIC protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032732">
        <property type="term" value="P:positive regulation of interleukin-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106272">
        <property type="term" value="P:protein localization to ERGIC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902003">
        <property type="term" value="P:regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001928606" evidence="10">
        <location>
            <begin position="32"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="219" mass="24968" checksum="9D37777C21B69855" modified="2014-11-26" version="1">MSGLSGPPARRGRCPLALLLLFLLCPSLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTZ4</accession>
    <name>A0A096NTZ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BAG family molecular chaperone regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bcl-2-associated athanogene 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Bcl-2-binding protein Bis</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BAG3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003904381.3">
        <property type="nucleotide sequence ID" value="XM_003904332.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NTZ4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016515"/>
    <dbReference type="Ensembl" id="ENSPANT00000023822.3">
        <property type="protein sequence ID" value="ENSPANP00000016515.3"/>
        <property type="gene ID" value="ENSPANG00000020521.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997141"/>
    <dbReference type="KEGG" id="panu:100997141"/>
    <dbReference type="CTD" id="9531"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159204"/>
    <dbReference type="HOGENOM" id="CLU_034378_0_0_1"/>
    <dbReference type="OMA" id="QKGEPSM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020521">
        <property type="expression patterns" value="Expressed in gastrocnemius and 63 other cell types or tissues"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUE6</accession>
    <name>A0A096NUE6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Interferon regulatory factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IRF5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_009203841.3"/>
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    <dbReference type="RefSeq" id="XP_009202106.1">
        <property type="nucleotide sequence ID" value="XM_009203842.4"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPANT00000013170.3">
        <property type="protein sequence ID" value="ENSPANP00000016670.1"/>
        <property type="gene ID" value="ENSPANG00000018384.3"/>
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    <dbReference type="GeneID" id="101025947"/>
    <dbReference type="KEGG" id="panu:101025947"/>
    <dbReference type="CTD" id="3663"/>
    <dbReference type="eggNOG" id="ENOG502QSKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159926"/>
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    <dbReference type="OMA" id="FQYRGQP"/>
    <dbReference type="OrthoDB" id="9856880at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018384">
        <property type="expression patterns" value="Expressed in esophagus and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUE6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="term" value="F:protein serine/threonine kinase binding"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to muramyl dipeptide"/>
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        <property type="term" value="P:cellular response to peptidoglycan"/>
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        <property type="term" value="P:cellular response to virus"/>
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        <property type="term" value="P:cytokine-mediated signaling pathway"/>
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        <property type="term" value="P:innate immune response"/>
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        <property type="term" value="P:nucleotide-binding oligomerization domain containing 2 signaling pathway"/>
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        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of cytokine production involved in immune response"/>
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        <property type="term" value="P:positive regulation of interleukin-12 production"/>
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        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Interferon regulatory factor 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative interferon regulatory factor 6"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
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    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
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    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11949:SF10">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
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    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="10">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="146"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="500"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
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    <evidence type="ECO:0000313" key="11">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="500" mass="56367" checksum="2552A9D8AA825A45" modified="2014-11-26" version="1">MNQSIPGAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFYIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLFYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEEELQRMLPSLSLTDAVQSGPHMAPYSLLKDDVKWPPTLQPPVVLGPPAPDPRPLAPPPGNPAGFRELFPEVLEPGPLAASLPPASEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASVHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDHMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGAGQGPWPMHPAGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUF8</accession>
    <name>A0A096NUF8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPS4 biosis of lysosomal organelles complex 3 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HPS4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003905400.2">
        <property type="nucleotide sequence ID" value="XM_003905351.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003905401.2">
        <property type="nucleotide sequence ID" value="XM_003905352.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009215248.2">
        <property type="nucleotide sequence ID" value="XM_009216984.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUF8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016682"/>
    <dbReference type="Ensembl" id="ENSPANT00000008675.3">
        <property type="protein sequence ID" value="ENSPANP00000016682.2"/>
        <property type="gene ID" value="ENSPANG00000026320.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007586"/>
    <dbReference type="KEGG" id="panu:101007586"/>
    <dbReference type="CTD" id="89781"/>
    <dbReference type="eggNOG" id="ENOG502QSIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007349"/>
    <dbReference type="HOGENOM" id="CLU_028579_0_0_1"/>
    <dbReference type="OMA" id="YACCSPV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026320">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042827">
        <property type="term" value="C:platelet dense granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903232">
        <property type="term" value="P:melanosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="3">
        <location>
            <begin position="599"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016682.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="708" mass="76936" checksum="5A60170BCEE70A1B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUK0</accession>
    <name>A0A096NUK0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DNAL1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with ZMYND10 (via C-terminus). Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017816843.1">
        <property type="nucleotide sequence ID" value="XM_017961354.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUK0"/>
    <dbReference type="SMR" id="A0A096NUK0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016724"/>
    <dbReference type="Ensembl" id="ENSPANT00000021310.3">
        <property type="protein sequence ID" value="ENSPANP00000016724.1"/>
        <property type="gene ID" value="ENSPANG00000015764.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005389"/>
    <dbReference type="KEGG" id="panu:101005389"/>
    <dbReference type="CTD" id="83544"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016904"/>
    <dbReference type="HOGENOM" id="CLU_092189_0_0_1"/>
    <dbReference type="OMA" id="NCERISM"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015764">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUK0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF33">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="190" mass="21519" checksum="B2F419D47F7F9A4D" modified="2014-11-26" version="1">MAKATTIKEALARWEEKTGQRPSEAKEIKLYAQIPPIEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHVMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAENNWIEEATKRVPKLKKLDGTPVIKGDEEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NV33</accession>
    <name>A0A096NV33_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6 14">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GNPNAT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6 14"/>
    <dbReference type="RefSeq" id="XP_003901851.1">
        <property type="nucleotide sequence ID" value="XM_003901802.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796925.1">
        <property type="nucleotide sequence ID" value="XM_021941233.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NV33"/>
    <dbReference type="SMR" id="A0A096NV33"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016908"/>
    <dbReference type="Ensembl" id="ENSPANT00000026455.3">
        <property type="protein sequence ID" value="ENSPANP00000016908.1"/>
        <property type="gene ID" value="ENSPANG00000000766.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017035"/>
    <dbReference type="KEGG" id="panu:101017035"/>
    <dbReference type="CTD" id="64841"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008666"/>
    <dbReference type="HOGENOM" id="CLU_072095_1_0_1"/>
    <dbReference type="OMA" id="LVVEMKF"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000766">
        <property type="expression patterns" value="Expressed in pyloric antrum and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000031">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="184" mass="20749" checksum="E9F31803CF633BBF" modified="2014-11-26" version="1">MKPDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCRRFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWP7</accession>
    <name>A0A096NWP7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor APC domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SAPCD2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031510591.1">
        <property type="nucleotide sequence ID" value="XM_031654731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWP7"/>
    <dbReference type="Ensembl" id="ENSPANT00000028841.3">
        <property type="protein sequence ID" value="ENSPANP00000017475.3"/>
        <property type="gene ID" value="ENSPANG00000026260.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011041"/>
    <dbReference type="KEGG" id="panu:101011041"/>
    <dbReference type="CTD" id="89958"/>
    <dbReference type="eggNOG" id="ENOG502QUJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008072"/>
    <dbReference type="HOGENOM" id="CLU_024930_0_0_1"/>
    <dbReference type="OMA" id="PAHHNRT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026260">
        <property type="expression patterns" value="Expressed in descending colon and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904777">
        <property type="term" value="P:negative regulation of protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF3">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017475.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="243" mass="27003" checksum="2BCA57B177A60937" modified="2022-05-25" version="3">MPGWCPRPQEWAEMWRLLYLSRAWPGWSGGEPGPCLSTIGAVACRALEVDSGDARRAPRARGERRRHTITSGVDCGLLKQMKELEQEKEVLLQGLEMMARGRDWYQQQLQRVQERQRRLGQSRASADCGAAGSPRPLGRLLPKVQEVARCLGELLAAACASRVLPSSSSGPPCPALTSTSPLGWQQQTILMLKEQNRLLTQEVTEKSERITQLEQEKSALIKQLFEARALSQQDGGPLDSTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWW4</accession>
    <name>A0A096NWW4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIX homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SIX2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NWW4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017550"/>
    <dbReference type="Ensembl" id="ENSPANT00000028989.3">
        <property type="protein sequence ID" value="ENSPANP00000017550.2"/>
        <property type="gene ID" value="ENSPANG00000022339.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158292"/>
    <dbReference type="HOGENOM" id="CLU_046914_2_0_1"/>
    <dbReference type="OMA" id="IHHHALQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022339">
        <property type="expression patterns" value="Expressed in adrenal cortex and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072137">
        <property type="term" value="P:condensed mesenchymal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072161">
        <property type="term" value="P:mesenchymal cell differentiation involved in kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072038">
        <property type="term" value="P:mesenchymal stem cell maintenance involved in nephron morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097168">
        <property type="term" value="P:mesenchymal stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003337">
        <property type="term" value="P:mesenchymal to epithelial transition involved in metanephros morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007501">
        <property type="term" value="P:mesodermal cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042474">
        <property type="term" value="P:middle ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030857">
        <property type="term" value="P:negative regulation of epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902732">
        <property type="term" value="P:positive regulation of chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090189">
        <property type="term" value="P:regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032330">
        <property type="term" value="P:regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030278">
        <property type="term" value="P:regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017550.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="300" mass="33429" checksum="FB2F307D31D9D36F" modified="2022-05-25" version="2">MCRVNREPGRDAATWGEEEPWEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXN7</accession>
    <name>A0A096NXN7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-phosphoxylose phosphatase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Acid phosphatase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PXYLP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:56512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:14559"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:140495"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with B3GAT3; the interaction increases the 2-phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3-mediated manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895071.1">
        <property type="nucleotide sequence ID" value="XM_003895022.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXN7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017838"/>
    <dbReference type="Ensembl" id="ENSPANT00000006027.3">
        <property type="protein sequence ID" value="ENSPANP00000017838.1"/>
        <property type="gene ID" value="ENSPANG00000018293.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997174"/>
    <dbReference type="KEGG" id="panu:100997174"/>
    <dbReference type="CTD" id="92370"/>
    <dbReference type="eggNOG" id="KOG3672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016324"/>
    <dbReference type="HOGENOM" id="CLU_033855_1_0_1"/>
    <dbReference type="OMA" id="YIWNAAE"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018293">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NXN7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010909">
        <property type="term" value="P:positive regulation of heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000011">
        <property type="entry name" value="2-phosphoxylose phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="480" mass="55157" checksum="7F4888252AFFB1DA" modified="2014-11-26" version="1">MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTAKNGVSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFVSHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHLCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYLGYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPNEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSSTNYYDACHREGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NY31</accession>
    <name>A0A096NY31_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome maturation protein SBDS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SBDS</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895961.1">
        <property type="nucleotide sequence ID" value="XM_003895912.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NY31"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017991"/>
    <dbReference type="Ensembl" id="ENSPANT00000011016.3">
        <property type="protein sequence ID" value="ENSPANP00000017991.1"/>
        <property type="gene ID" value="ENSPANG00000004078.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999172"/>
    <dbReference type="KEGG" id="panu:100999172"/>
    <dbReference type="CTD" id="51119"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008135"/>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004078">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048539">
        <property type="term" value="P:bone marrow development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030595">
        <property type="term" value="P:leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000009">
        <property type="entry name" value="SBDS ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.900:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF6">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="13">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="14">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="250" mass="28764" checksum="D35816513850A4A7" modified="2014-11-26" version="1">MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFLLPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZV3</accession>
    <name>A0A096NZV3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ubiquitin carboxyl-terminal hydrolase 39</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">U4/U6.U5 tri-snRNP-associated 65 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">USP39</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003908958.1">
        <property type="nucleotide sequence ID" value="XM_003908909.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017803191.1">
        <property type="nucleotide sequence ID" value="XM_017947702.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZV3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018628"/>
    <dbReference type="Ensembl" id="ENSPANT00000026955.3">
        <property type="protein sequence ID" value="ENSPANP00000018628.1"/>
        <property type="gene ID" value="ENSPANG00000017132.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021919"/>
    <dbReference type="KEGG" id="panu:101021919"/>
    <dbReference type="CTD" id="10713"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007992"/>
    <dbReference type="HOGENOM" id="CLU_016848_4_0_1"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017132">
        <property type="expression patterns" value="Expressed in adrenal cortex and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZV3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Peptidase_C19M"/>
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        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
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        <property type="entry name" value="Cysteine proteinases"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
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        <property type="entry name" value="zf-UBP"/>
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        <property type="entry name" value="RING/U-box"/>
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    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="25">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="24">
        <location>
            <begin position="225"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="85"/>
            <end position="95"/>
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    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00064202"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00071645"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00079185"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50271"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018628.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="565" mass="65382" checksum="28FDFB8BFAEF5D4D" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1A3</accession>
    <name>A0A096P1A3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCL19</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
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        <property type="gene ID" value="ENSPANG00000025338.3"/>
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    <dbReference type="eggNOG" id="ENOG502SENW">
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        <property type="component" value="Chromosome 13"/>
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031735">
        <property type="term" value="F:CCR10 chemokine receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0038119">
        <property type="term" value="P:CCL19-activated CCR7 signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071380">
        <property type="term" value="P:cellular response to prostaglandin E stimulus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:eosinophil chemotaxis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
    <dbReference type="CDD" id="cd01119">
        <property type="entry name" value="Chemokine_CC_DCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000012">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000827">
        <property type="entry name" value="Chemokine_CC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034133">
        <property type="entry name" value="Chemokine_CC_DCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF80">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4 9" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035341301" description="C-C motif chemokine" evidence="9">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019128.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="103" mass="11308" checksum="F2B905BD7A41E7D5" modified="2022-05-25" version="3">MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFRYLLIKDGCRVPAVVFTTLRGRQLCAPPDQSWVERIIQRLQRTSTKASLLPGPVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3L6</accession>
    <name>A0A096P3L6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras suppressor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSU1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031508333.1">
        <property type="nucleotide sequence ID" value="XM_031652473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P3L6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019941"/>
    <dbReference type="Ensembl" id="ENSPANT00000021248.3">
        <property type="protein sequence ID" value="ENSPANP00000019941.2"/>
        <property type="gene ID" value="ENSPANG00000023150.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025051"/>
    <dbReference type="KEGG" id="panu:101025051"/>
    <dbReference type="CTD" id="6251"/>
    <dbReference type="eggNOG" id="KOG0617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158676"/>
    <dbReference type="HOGENOM" id="CLU_126639_0_0_1"/>
    <dbReference type="OMA" id="RHMQGGR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023150">
        <property type="expression patterns" value="Expressed in adrenal cortex and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000159">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="7">
        <location>
            <begin position="105"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019941.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="277" mass="31535" checksum="2E5F3FB1BC8EFED9" modified="2022-05-25" version="2">MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTTVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFSSLPALEVLDLTYNNLNENCLPGNFFYLTTLCALYLSDNNFEILPPDIGKLTKMQTLSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4G5</accession>
    <name>A0A096P4G5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannose-binding protein C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">MBP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mannan-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mannose-binding lectin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P4G5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020240"/>
    <dbReference type="Ensembl" id="ENSPANT00000018971.3">
        <property type="protein sequence ID" value="ENSPANP00000020240.2"/>
        <property type="gene ID" value="ENSPANG00000022578.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000061136.1">
        <property type="protein sequence ID" value="ENSPANP00000049285.1"/>
        <property type="gene ID" value="ENSPANG00000022578.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154368"/>
    <dbReference type="HOGENOM" id="CLU_049894_3_0_1"/>
    <dbReference type="OMA" id="ACSVITC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022578">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000088">
        <property type="entry name" value="Mannose-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF35">
        <property type="entry name" value="MANNOSE-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0176">Collagen</keyword>
    <keyword evidence="14" id="KW-1018">Complement activation lectin pathway</keyword>
    <keyword evidence="10" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0465">Mannose-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 24" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044540393" description="Mannose-binding protein C" evidence="24">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="25">
        <location>
            <begin position="134"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020240.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="244" mass="25742" checksum="287BACB2D739E864" modified="2022-05-25" version="2">MFLFPSFPVLLLSVVTASCSETKACEDAQKTCSVITCGIPVTNGTPGRDGRDGPKGEKGEPGQGLRGLQGPPGKSGPPGNTGAPGIPGPRGQKGDHGDNSVAEAKLANLERQLQSLRAELDHMKKLQAFSLGKMSGKKLFVTNGERMPFSEVKALCAGLQATVAAPKNAEENKAIQDVAKDTAFLGITDEATEGQFMYVTGGRLTYSNWKKDEPNDHGSGEDCVILLSNGLWNDISCTFSFIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5L4</accession>
    <name>A0A096P5L4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratin 33A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KRT33A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P5L4"/>
    <dbReference type="Ensembl" id="ENSPANT00000008809.3">
        <property type="protein sequence ID" value="ENSPANP00000020639.1"/>
        <property type="gene ID" value="ENSPANG00000021574.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998247"/>
    <dbReference type="KEGG" id="panu:100998247"/>
    <dbReference type="eggNOG" id="ENOG502SNBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153980"/>
    <dbReference type="HOGENOM" id="CLU_012560_8_0_1"/>
    <dbReference type="OMA" id="XYETELS"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021557">
        <property type="expression patterns" value="Expressed in zone of skin and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF98">
        <property type="entry name" value="KERATIN, TYPE I CUTICULAR HA3-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="56"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="251"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="404" mass="45795" checksum="DA2C49675E505484" modified="2014-11-26" version="1">MSYSCGLPSLSCRTSCSSRPCVPPSCHGCTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEELQQKILCSKSENARLVVQIDNAKLASDDFRTKYETEMSLRQLVESDINGLRRILDELTLCRSDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRSQYEALVETNRREVEQWFATQTEELNKQVVSSAEQLQSYQAEIIELRRTVNALEIELQAQHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLPSNPCATTNACDKSIGPCISNPCGPRARCGPCNTFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWA3</accession>
    <name>A0A0A0MWA3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWA3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009090"/>
    <dbReference type="Ensembl" id="ENSPANT00000006558.3">
        <property type="protein sequence ID" value="ENSPANP00000009090.3"/>
        <property type="gene ID" value="ENSPANG00000004122.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160550"/>
    <dbReference type="HOGENOM" id="CLU_016492_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004122">
        <property type="expression patterns" value="Expressed in aorta and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MWA3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009090.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="471" mass="47846" checksum="2976EAD2106D045C" modified="2022-05-25" version="3">YETAEMAEEAQQQADGLALGGSHLRVSFCAPGPPGRSMLAALIAAQATALNRGKGLLPEPNILQLLNNLGPSASLQLLLNPLLHGSAGGKQGLLGAPPAMPLLSGPALSTALLQLALQTQGQKKPGILGDSPLGALQPGAQPANPLLGELPAGGGLPPELPPRRGKPPPLLPSVLGPAGGDREALGLGPPAAQLTPPPAPVGLRGSGLRGLQKDSGPLPTPPGVSLLGEPPKDYRIPLNPYLNLHSLLPASNLAGKEARAWGGAGRSRRPAEGPPPNPPAPGGGSSSSKAFQLKSRLLSPLSSARLPPEPGLSDSYGFDYPSDVGPRRLFSHPREPALGPHGPSRHKMSPPPSGFGERSSGGSGGGPLSHFYSGSPTSYFTSGLQAGLKQSHLSKAIGSSPLGSGEGLLGLGPGPNGHSHLLKTPLGGQKRSFAHLLPSPEPSPEGSYVGQHSQGLGGHYADSYLKRKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LCD0</accession>
    <name>A0A2I3LCD0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 805</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LCD0"/>
    <dbReference type="Ensembl" id="ENSPANT00000057443.2">
        <property type="protein sequence ID" value="ENSPANP00000021109.1"/>
        <property type="gene ID" value="ENSPANG00000011940.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000058447.2">
        <property type="protein sequence ID" value="ENSPANP00000023657.1"/>
        <property type="gene ID" value="ENSPANG00000011940.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159953"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011940">
        <property type="expression patterns" value="Expressed in thymus and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LCD0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001494">
        <property type="entry name" value="zinc finger protein 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000561">
        <property type="entry name" value="Zinc finger protein 30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001291">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000493">
        <property type="entry name" value="Zinc finger protein 805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000896">
        <property type="entry name" value="Zinc finger protein 805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF154">
        <property type="entry name" value="ZINC FINGER PROTEIN 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="628" mass="71356" checksum="8F748EB21018E84D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LEX9</accession>
    <name>A0A2I3LEX9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase AMP-activated non-catalytic subunit beta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRKAB2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009215580.1">
        <property type="nucleotide sequence ID" value="XM_009217316.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017802050.1">
        <property type="nucleotide sequence ID" value="XM_017946561.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LEX9"/>
    <dbReference type="SMR" id="A0A2I3LEX9"/>
    <dbReference type="Ensembl" id="ENSPANT00000039129.2">
        <property type="protein sequence ID" value="ENSPANP00000022006.2"/>
        <property type="gene ID" value="ENSPANG00000018115.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013013"/>
    <dbReference type="KEGG" id="panu:101013013"/>
    <dbReference type="CTD" id="5565"/>
    <dbReference type="GeneTree" id="ENSGT00940000159284"/>
    <dbReference type="OMA" id="HEYKFMV"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018115">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LEX9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000139">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF92">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="9">
        <location>
            <begin position="182"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022006.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="272" mass="30330" checksum="5A1DDC870B80C817" modified="2022-05-25" version="2">MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYVFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LKS8</accession>
    <name>A0A2I3LKS8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear envelope phosphatase-regulatory subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transmembrane protein 188</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LKS8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024038"/>
    <dbReference type="Ensembl" id="ENSPANT00000040526.2">
        <property type="protein sequence ID" value="ENSPANP00000024038.2"/>
        <property type="gene ID" value="ENSPANG00000032576.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008576"/>
    <dbReference type="OMA" id="ITTRARC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032576">
        <property type="expression patterns" value="Expressed in thyroid gland and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024038.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="137" mass="15426" checksum="5E7E2C1E4E3810F6" modified="2022-05-25" version="2">MNLLEQAEELKAFERRLTEYIHCLQPATGHWRMLLLVVSVCTATGAWNWLIDPETQKVSFFTSLRNHPFFTISCITLIGLSFAGIHKRGVVPSIIACEYTSLLINYVLSGTLIVIVLDNWILHCGRQAVTLVLHGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LNX3</accession>
    <name>A0A2I3LNX3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RB binding protein 7, chromatin remodeling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RBBP7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917506.1">
        <property type="nucleotide sequence ID" value="XM_003917457.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LNX3"/>
    <dbReference type="SMR" id="A0A2I3LNX3"/>
    <dbReference type="Ensembl" id="ENSPANT00000031277.2">
        <property type="protein sequence ID" value="ENSPANP00000025186.2"/>
        <property type="gene ID" value="ENSPANG00000004461.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010844"/>
    <dbReference type="CTD" id="5931"/>
    <dbReference type="GeneTree" id="ENSGT00940000154748"/>
    <dbReference type="OMA" id="KIRAMPA"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004461">
        <property type="expression patterns" value="Expressed in adrenal medulla and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LNX3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="13">
        <location>
            <begin position="62"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="356"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025186.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="469" mass="52277" checksum="06F5F71890FF9251" modified="2022-05-25" version="2">MAAEAGVVGAGASPDGDWRDQACGLLVHVQLSSRVGRAAPVRTGRHLRTVFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LTC6</accession>
    <name>A0A2I3LTC6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LTC6"/>
    <dbReference type="Ensembl" id="ENSPANT00000044442.2">
        <property type="protein sequence ID" value="ENSPANP00000026720.1"/>
        <property type="gene ID" value="ENSPANG00000035797.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00620000089223"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035797">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="70" mass="8099" checksum="D939C55C1185540B" modified="2018-02-28" version="1">MYIARSFFPVDANYRIFRFLCSLSPIVAPFANSKYIIFIYSCVFFPPLDCELLEGQDLSLFPVPRTWPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LTX6</accession>
    <name>A0A2I3LTX6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LTX6"/>
    <dbReference type="Ensembl" id="ENSPANT00000059135.2">
        <property type="protein sequence ID" value="ENSPANP00000026897.2"/>
        <property type="gene ID" value="ENSPANG00000035318.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000148664"/>
    <dbReference type="OMA" id="ACTMCER"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035318">
        <property type="expression patterns" value="Expressed in thymus and 7 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026897.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="75" mass="8549" checksum="0F2B40AAFF2F1163" modified="2022-05-25" version="2">MENLTKHSIECSSFRDLLQTLPETQLCVSSSYSSWCSDCKAISMAWQGFSWRAMEEDRPAGCRLCSRACTVSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LUC6</accession>
    <name>A0A2I3LUC6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Leucine rich repeat containing G protein-coupled receptor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LGR6</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031512912.1">
        <property type="nucleotide sequence ID" value="XM_031657052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LUC6"/>
    <dbReference type="Ensembl" id="ENSPANT00000031838.2">
        <property type="protein sequence ID" value="ENSPANP00000027054.2"/>
        <property type="gene ID" value="ENSPANG00000016204.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009928"/>
    <dbReference type="KEGG" id="panu:101009928"/>
    <dbReference type="CTD" id="59352"/>
    <dbReference type="GeneTree" id="ENSGT00940000159939"/>
    <dbReference type="OMA" id="YGVCAGF"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016204">
        <property type="expression patterns" value="Expressed in aorta and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LUC6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990523">
        <property type="term" value="P:bone regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15362">
        <property type="entry name" value="7tmA_LGR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000028">
        <property type="entry name" value="leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000028">
        <property type="entry name" value="leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING G PROTEIN-COUPLED RECEPTOR 6"/>
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        <property type="entry name" value="LRR_8"/>
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        <property type="entry name" value="GLYCHORMONER"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
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        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="L domain-like"/>
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        <property type="entry name" value="LRR"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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    <feature type="chain" id="PRO_5035193603" evidence="16">
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            <begin position="25"/>
            <end position="966"/>
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            <begin position="566"/>
            <end position="587"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="599"/>
            <end position="624"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="644"/>
            <end position="665"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="686"/>
            <end position="708"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="728"/>
            <end position="754"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="775"/>
            <end position="798"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="810"/>
            <end position="830"/>
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    </feature>
    <feature type="domain" description="LRRNT" evidence="17">
        <location>
            <begin position="34"/>
            <end position="70"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027054.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="966" mass="104261" checksum="9C1B64FFC567DD4E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LXT3</accession>
    <name>A0A2I3LXT3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrilin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MATN2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in matrix assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000028265.2"/>
        <property type="gene ID" value="ENSPANG00000024751.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158008"/>
    <dbReference type="OMA" id="CATEDHA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024751">
        <property type="expression patterns" value="Expressed in pineal body and 63 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3LXT3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120216">
        <property type="term" value="C:matrilin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031104">
        <property type="term" value="P:dendrite regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008347">
        <property type="term" value="P:glial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
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    <dbReference type="CDD" id="cd01475">
        <property type="entry name" value="vWA_Matrilin"/>
        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="3.40.50.410:FF:000004">
        <property type="entry name" value="collagen alpha-6(VI) chain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Matrilin 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="matrilin-2 isoform X1"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="matrilin-2 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="matrilin-2 isoform X2"/>
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        <property type="entry name" value="matrilin-2 isoform X2"/>
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        <property type="entry name" value="matrilin-2 isoform X3"/>
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        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
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    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="cEGF"/>
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        <property type="entry name" value="ECM_Assembly_Org"/>
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        <property type="entry name" value="FXa_inhibition"/>
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        <property type="entry name" value="Matrilin_ccoil"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM01279">
        <property type="entry name" value="Matrilin_ccoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58002">
        <property type="entry name" value="Chicken cartilage matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035169301" description="Matrilin-2" evidence="13">
        <location>
            <begin position="24"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="614"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="884"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028265.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="915" mass="102176" checksum="7D1D0CBD5E720257" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M576</accession>
    <name>A0A2I3M576_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DnaJ homolog subfamily C member 17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May negatively affect PAX8-induced thyroglobulin/TG transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M576"/>
    <dbReference type="STRING" id="9555.ENSPANP00000030833"/>
    <dbReference type="Ensembl" id="ENSPANT00000047750.2">
        <property type="protein sequence ID" value="ENSPANP00000030833.1"/>
        <property type="gene ID" value="ENSPANG00000024039.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155132"/>
    <dbReference type="OMA" id="GIAVIFH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000059">
        <property type="entry name" value="dnaJ homolog subfamily C member 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="76"/>
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    </feature>
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        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053783"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="171" mass="19909" checksum="D8AA53BCE026ED05" modified="2018-02-28" version="1">MAVTKELLQMDLYALLGIEQTATDKEVKKAYRQKALSYHPDKNPDNPRAAELFPQLSRALEVLTDATARATYDKVRKARKQARVRLELEARERQAQAQRSKDAEGSRNPRTLEQEIHEPRSRHCTPAWVTRVRLRLEKKQKRKYLGWLQWFMPVLPAFSAAKMRGSLEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M6E9</accession>
    <name>A0A2I3M6E9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Vascular cell adhesion protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">VCAM1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="Ensembl" id="ENSPANT00000049021.2">
        <property type="protein sequence ID" value="ENSPANP00000031321.1"/>
        <property type="gene ID" value="ENSPANG00000007779.3"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:integrin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ig"/>
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        <property type="entry name" value="Vascular cell adhesion molecule 1"/>
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    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143601" description="Vascular cell adhesion protein 1" evidence="18">
        <location>
            <begin position="25"/>
            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="223"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="540" mass="59217" checksum="0A58346A36B34BB2" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MB78</accession>
    <name>A0A2I3MB78_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stress-activated protein kinase JNK</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MAPK10</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MB78"/>
    <dbReference type="SMR" id="A0A2I3MB78"/>
    <dbReference type="Ensembl" id="ENSPANT00000044943.2">
        <property type="protein sequence ID" value="ENSPANP00000032986.2"/>
        <property type="gene ID" value="ENSPANG00000021440.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153692"/>
    <dbReference type="OMA" id="QGHAFES"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021440">
        <property type="expression patterns" value="Expressed in Ammon's horn and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MB78">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038095">
        <property type="term" value="P:Fc-epsilon receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="67"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="408"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032986.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="467" mass="52963" checksum="C805460DD37FDC58" modified="2022-05-25" version="2">MVFMSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MCV6</accession>
    <name>A0A2I3MCV6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MCV6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033622"/>
    <dbReference type="Ensembl" id="ENSPANT00000055687.2">
        <property type="protein sequence ID" value="ENSPANP00000033622.2"/>
        <property type="gene ID" value="ENSPANG00000032704.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154568"/>
    <dbReference type="OMA" id="DAYQPCP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032704">
        <property type="expression patterns" value="Expressed in putamen"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033622.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="188" mass="21526" checksum="AB53D488F4B43609" modified="2022-05-25" version="2">MAKQYMEKSLLVPDHVITRLMMSELENRPGQHWLLDGFPRTLGQAEALDKICEVDLVISLNISFETLKDHLSRHWIHPPSGRVYNLDFNPPHVYGIDDVTGEPSVQQEDDKPEAVAARLRQYKDVAKPVIELHKSQGVFHQYSSGTETNKIWPYVYALFSNKITPIQSKDAYRPCPVEEPGRCGRPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MD97</accession>
    <name>A0A2I3MD97_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase DCLK1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Doublecortin-like and CAM kinase-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Doublecortin-like kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">DCLK1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_009190028.2">
        <property type="nucleotide sequence ID" value="XM_009191764.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017806664.1">
        <property type="nucleotide sequence ID" value="XM_017951175.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MD97"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033686"/>
    <dbReference type="Ensembl" id="ENSPANT00000047566.2">
        <property type="protein sequence ID" value="ENSPANP00000033686.1"/>
        <property type="gene ID" value="ENSPANG00000003398.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001394"/>
    <dbReference type="CTD" id="9201"/>
    <dbReference type="GeneTree" id="ENSGT00940000154956"/>
    <dbReference type="OMA" id="CWEFEGS"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003398">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MD97">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17140">
        <property type="entry name" value="DCX1_DCLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17069">
        <property type="entry name" value="DCX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14183">
        <property type="entry name" value="STKc_DCKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000003">
        <property type="entry name" value="Neuronal migration protein doublecortin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000066">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000057">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase DCLK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="22">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="22">
        <location>
            <begin position="186"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="390"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="287"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="697"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="740" mass="82252" checksum="189DDD5A8A062EDF" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MFA3</accession>
    <name>A0A2I3MFA3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase NRDP1</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RING finger protein 41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase NRDP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RNF41</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003906634.1">
        <property type="nucleotide sequence ID" value="XM_003906585.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021778204.1">
        <property type="nucleotide sequence ID" value="XM_021922512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MFA3"/>
    <dbReference type="SMR" id="A0A2I3MFA3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000034379"/>
    <dbReference type="Ensembl" id="ENSPANT00000037691.2">
        <property type="protein sequence ID" value="ENSPANP00000034379.1"/>
        <property type="gene ID" value="ENSPANG00000034803.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101004944"/>
    <dbReference type="KEGG" id="panu:101004944"/>
    <dbReference type="CTD" id="10193"/>
    <dbReference type="GeneTree" id="ENSGT00530000063647"/>
    <dbReference type="OMA" id="QYENYVC"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034803">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005128">
        <property type="term" value="F:erythropoietin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005135">
        <property type="term" value="F:interleukin-3 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000379">
        <property type="term" value="P:positive regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045619">
        <property type="term" value="P:regulation of lymphocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045637">
        <property type="term" value="P:regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16634">
        <property type="entry name" value="mRING-HC-C3HC3D_Nrdp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000268">
        <property type="entry name" value="E3 ubiquitin-protein ligase NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000302">
        <property type="entry name" value="E3 ubiquitin-protein ligase NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015036">
        <property type="entry name" value="NRDP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037255">
        <property type="entry name" value="NRDP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08941">
        <property type="entry name" value="USP8_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160088">
        <property type="entry name" value="NRDP1 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="16">
        <location>
            <begin position="78"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="317" mass="35905" checksum="46AE87AF8BE1A369" modified="2018-02-28" version="1">MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MJW3</accession>
    <name>A0A2I3MJW3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sacsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DnaJ homolog subfamily C member 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SACS</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="6">Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.</text>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000035886.2"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
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    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MKE8"/>
    <dbReference type="Ensembl" id="ENSPANT00000048306.2">
        <property type="protein sequence ID" value="ENSPANP00000036076.2"/>
        <property type="gene ID" value="ENSPANG00000029610.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240503"/>
    <dbReference type="OMA" id="RAPDISC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029610">
        <property type="expression patterns" value="Expressed in amygdala and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036076.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="157" mass="17598" checksum="AC950D034376D953" modified="2022-05-25" version="2">MAASAALFSRLRSGLRLGSLGLCTRLATPPLRAPDQDISCLNRDPPRVVVVDCKKEAFRLQPYNGVALQPWDGNPDDRVLLDLSAFLKTIALNGVEDVRNVLEHYALEDDPLAAFKQQQSRLEQEEQQRLAELSKSKKQNLFLGSLTSRLWSRSKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3ML00</accession>
    <name>A0A2I3ML00_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallothionein superfamily. Type 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3ML00"/>
    <dbReference type="Ensembl" id="ENSPANT00000037010.2">
        <property type="protein sequence ID" value="ENSPANP00000036397.1"/>
        <property type="gene ID" value="ENSPANG00000047587.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182967"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006266">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3ML00">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071280">
        <property type="term" value="P:cellular response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071294">
        <property type="term" value="P:cellular response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010273">
        <property type="term" value="P:detoxification of copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.10.10">
        <property type="entry name" value="Metallothionein Isoform II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017854">
        <property type="entry name" value="Metalthion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023587">
        <property type="entry name" value="Metalthion_dom_sf_vert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000006">
        <property type="entry name" value="Metalthion_vert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018064">
        <property type="entry name" value="Metalthion_vert_metal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23299">
        <property type="entry name" value="METALLOTHIONEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23299:SF22">
        <property type="entry name" value="METALLOTHIONEIN-1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00131">
        <property type="entry name" value="Metallothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57868">
        <property type="entry name" value="Metallothionein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00203">
        <property type="entry name" value="METALLOTHIONEIN_VRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="73" mass="7834" checksum="7A37C0C40FFF4AA7" modified="2018-02-28" version="1">MDPNCSCVAGDSCTCAGSCKCKECKCTSCKKSKWDSLFPLTPHCPPACPLSTILRGMKAVWGCPITRKLLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MP92</accession>
    <name>A0A2I3MP92_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a homohexamer that can probably bind six kinase subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MP92"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037475"/>
    <dbReference type="Ensembl" id="ENSPANT00000048086.2">
        <property type="protein sequence ID" value="ENSPANP00000037475.2"/>
        <property type="gene ID" value="ENSPANG00000033818.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182971"/>
    <dbReference type="OMA" id="VCKTHLM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033818">
        <property type="expression patterns" value="Expressed in pancreas and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037475.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="89" mass="10555" checksum="F5CF9A2F538E0BE6" modified="2022-05-25" version="2">LRTRVEYQHVMLPTDTAKLVHKTHLMSESEWRNLGIQQSQGWVHYMIHEPERHILLSWHPLPKKPKKGSWQAAFQPQALHSSPYFLTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MPY8</accession>
    <name>A0A2I3MPY8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat domain 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANKRD46</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003903078.1">
        <property type="nucleotide sequence ID" value="XM_003903029.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021798232.1">
        <property type="nucleotide sequence ID" value="XM_021942540.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021798233.1">
        <property type="nucleotide sequence ID" value="XM_021942541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MPY8"/>
    <dbReference type="Ensembl" id="ENSPANT00000045741.2">
        <property type="protein sequence ID" value="ENSPANP00000037843.1"/>
        <property type="gene ID" value="ENSPANG00000000325.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018604"/>
    <dbReference type="KEGG" id="panu:101018604"/>
    <dbReference type="CTD" id="157567"/>
    <dbReference type="GeneTree" id="ENSGT00940000157094"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000325">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MPY8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="228" mass="25286" checksum="15DF578B49A76152" modified="2018-02-28" version="1">MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGAHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEFVEDLGFWRVLLLVFVIALLSLGIAYYVSGVLPFVENQPELVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MSC9</accession>
    <name>A0A2I3MSC9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Low molecular weight phosphotyrosine protein phosphatase</fullName>
            <shortName evidence="14">LMW-PTP</shortName>
            <shortName evidence="14">LMW-PTPase</shortName>
            <ecNumber evidence="3 14">3.1.3.2</ecNumber>
            <ecNumber evidence="4 14">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 14">Low molecular weight cytosolic acid phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15018"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3 14"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4 14"/>
    <dbReference type="RefSeq" id="XP_003908262.1">
        <property type="nucleotide sequence ID" value="XM_003908213.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MSC9"/>
    <dbReference type="Ensembl" id="ENSPANT00000038032.2">
        <property type="protein sequence ID" value="ENSPANP00000038654.1"/>
        <property type="gene ID" value="ENSPANG00000022345.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998321"/>
    <dbReference type="KEGG" id="panu:100998321"/>
    <dbReference type="CTD" id="52"/>
    <dbReference type="GeneTree" id="ENSGT00940000162690"/>
    <dbReference type="OMA" id="VCHGNIC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022345">
        <property type="expression patterns" value="Expressed in spleen and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MSC9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF34">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="15">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="158" mass="18021" checksum="5C8EDE2DC6808506" modified="2018-02-28" version="1">MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNAPDYRGQNCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MTH0</accession>
    <name>A0A2I3MTH0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HYOU1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031508743.1">
        <property type="nucleotide sequence ID" value="XM_031652883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508744.1">
        <property type="nucleotide sequence ID" value="XM_031652884.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508745.1">
        <property type="nucleotide sequence ID" value="XM_031652885.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508746.1">
        <property type="nucleotide sequence ID" value="XM_031652886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508749.1">
        <property type="nucleotide sequence ID" value="XM_031652889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MTH0"/>
    <dbReference type="Ensembl" id="ENSPANT00000051241.2">
        <property type="protein sequence ID" value="ENSPANP00000038960.2"/>
        <property type="gene ID" value="ENSPANG00000012741.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009036"/>
    <dbReference type="KEGG" id="panu:101009036"/>
    <dbReference type="CTD" id="10525"/>
    <dbReference type="GeneTree" id="ENSGT00940000157686"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012741">
        <property type="expression patterns" value="Expressed in pancreas and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MTH0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903298">
        <property type="term" value="P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000013">
        <property type="entry name" value="Hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000009">
        <property type="entry name" value="Hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000012">
        <property type="entry name" value="Hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328827" description="Hypoxia up-regulated protein 1" evidence="12">
        <location>
            <begin position="35"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="909"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038960.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111400" checksum="A6D283B7DA078441" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MY99</accession>
    <name>A0A2I3MY99_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RBPJ-interacting and tubulin-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RBPJ-interacting and tubulin-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RITA1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with RBPJ/RBPSUH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RITA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907243.1">
        <property type="nucleotide sequence ID" value="XM_003907194.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MY99"/>
    <dbReference type="Ensembl" id="ENSPANT00000046232.2">
        <property type="protein sequence ID" value="ENSPANP00000040734.1"/>
        <property type="gene ID" value="ENSPANG00000005344.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012408"/>
    <dbReference type="CTD" id="84934"/>
    <dbReference type="GeneTree" id="ENSGT00390000013005"/>
    <dbReference type="OMA" id="WEGPWMA"/>
    <dbReference type="OrthoDB" id="10061257at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005344">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MY99">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031418">
        <property type="entry name" value="RITA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34917">
        <property type="entry name" value="RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34917:SF1">
        <property type="entry name" value="RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17066">
        <property type="entry name" value="RITA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="293" mass="31314" checksum="D7FDA7D43C09E163" modified="2018-02-28" version="1">MLREPRKQGLAGRAHLLSPGTTGSMKNPVGLTVSGMQTLRLQHRCRGSYRVQARTSYVDETLFGSPASTRPTPPDFDPPWVEKANRTRDVGKEASKALGAKGSCEATPSRGSTPTLTPRKKNKYRLISHTPSYCDESLFGSRSEGASFGAPRMAKGDAAKLRALFWTPPATPRGSHSPRPREAPLRAIHPAGPSKTEPGAAADSQKLSMDGLHSSCPLRRGLSHSLTHLNVPSTGHPATSASHTNGPQDLRPSTSGVTFRSPLVTSRARSVSISVPATPRRVGATQKAKPPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NAX3</accession>
    <name>A0A2I3NAX3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Methylcytosine dioxygenase TET</fullName>
            <ecNumber evidence="18">1.14.11.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TET3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 18">
            <text>a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53832"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="Rhea" id="RHEA-COMP:13657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="ChEBI" id="CHEBI:137732"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:53828"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:52636"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="18">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">The zinc ions have a structural role.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the TET family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.80" evidence="18"/>
    <dbReference type="RefSeq" id="XP_009182706.2">
        <property type="nucleotide sequence ID" value="XM_009184442.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000035692.2">
        <property type="protein sequence ID" value="ENSPANP00000045003.2"/>
        <property type="gene ID" value="ENSPANG00000024069.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013148"/>
    <dbReference type="KEGG" id="panu:101013148"/>
    <dbReference type="CTD" id="200424"/>
    <dbReference type="GeneTree" id="ENSGT00940000157631"/>
    <dbReference type="OMA" id="SVYSCHS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024069">
        <property type="expression patterns" value="Expressed in esophagus and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NAX3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070579">
        <property type="term" value="F:DNA 5-methylcytosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141166">
        <property type="term" value="P:chromosomal 5-methylcytosine DNA demethylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044727">
        <property type="term" value="P:epigenetic programing of male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044029">
        <property type="term" value="P:positive regulation of gene expression via chromosomal CpG island demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18897">
        <property type="entry name" value="TET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040175">
        <property type="entry name" value="TET1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046942">
        <property type="entry name" value="TET_oxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358:SF4">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01333">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="20">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="480"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="635"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1345"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1608"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045003.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1795" mass="193747" checksum="C0B485F4F0D51DA7" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NBC6</accession>
    <name>A0A2I3NBC6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Erythrocyte ankyrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ANK1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with a number of integral membrane proteins and cytoskeletal proteins. Interacts (via N-terminus) with SPTB/spectrin (beta chain). Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin. Interacts with HIF1AN. Interacts (via ANK 1-5 repeats) with RHCE; this interaction mediates the primary membrane attachment site for ANK1. Interacts (via ANK 1-2 repeats) with AQP1 (via the N-terminal). Interacts (via ANK 1-13 repeats) with EPB42. Interacts directly with SLC4A1 (via the cytoplasmic domain); this interaction is mediated by the SLC4A1 Band 3-II and Band 3-III dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000047819.2">
        <property type="protein sequence ID" value="ENSPANP00000045280.2"/>
        <property type="gene ID" value="ENSPANG00000007577.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155760"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007577">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014731">
        <property type="term" value="C:spectrin-associated cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08805">
        <property type="entry name" value="Death_ank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000010">
        <property type="entry name" value="Ankyrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2660:FF:000002">
        <property type="entry name" value="Ankyrin-1 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000002">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF71">
        <property type="entry name" value="ANKYRIN 1, ERYTHROCYTIC A ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="667"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="700"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="20">
        <location>
            <begin position="954"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="20">
        <location>
            <begin position="1111"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="19">
        <location>
            <begin position="1443"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1526"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1677"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1875"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1533"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1682"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1723"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1785"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1819"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1830"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1883"/>
            <end position="1896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045280.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1896" mass="208003" checksum="965B44638CAB3F45" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NCE1</accession>
    <name>A0A2I3NCE1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitogen-activated protein kinase 13</fullName>
            <ecNumber evidence="4">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MAPK13</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with MAPK8IP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003897564.1">
        <property type="nucleotide sequence ID" value="XM_003897515.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NCE1"/>
    <dbReference type="Ensembl" id="ENSPANT00000048084.2">
        <property type="protein sequence ID" value="ENSPANP00000045508.2"/>
        <property type="gene ID" value="ENSPANG00000000909.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024771"/>
    <dbReference type="KEGG" id="panu:101024771"/>
    <dbReference type="CTD" id="5603"/>
    <dbReference type="GeneTree" id="ENSGT00940000159584"/>
    <dbReference type="OMA" id="IIWREAL"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000909">
        <property type="expression patterns" value="Expressed in cornea and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NCE1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072740">
        <property type="term" value="P:cellular response to anisomycin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903936">
        <property type="term" value="P:cellular response to sodium arsenite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072709">
        <property type="term" value="P:cellular response to sorbitol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07879">
        <property type="entry name" value="STKc_p38delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000170">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000769">
        <property type="entry name" value="Mitogen-activated protein kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038785">
        <property type="entry name" value="MAPK13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045508.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="365" mass="42020" checksum="B9F104E24661684C" modified="2022-05-25" version="2">MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGAVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFHDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQALPQTPKKDFTQLFPRASPQATDLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPVARKDSRRRSGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NFP4</accession>
    <name>A0A2I3NFP4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NFP4"/>
    <dbReference type="Ensembl" id="ENSPANT00000038300.2">
        <property type="protein sequence ID" value="ENSPANP00000046724.1"/>
        <property type="gene ID" value="ENSPANG00000023765.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009386"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023765">
        <property type="expression patterns" value="Expressed in pyloric antrum and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NFP4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029377">
        <property type="entry name" value="TMEM220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15071">
        <property type="entry name" value="TMEM220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="130" mass="14631" checksum="10589DF3350C9A79" modified="2018-02-28" version="1">MAPSLWRACNGLMAAFFAMAAFVQVVYTIPAVLTLLVGLNPQVTGNVIWKSISAIHILFCMVWAVGLAYYLLHHTQQNILHEEEGRTPVGGRIQLAIAIIITLFPFISWVYIYINKEMRSSWPTHCKTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MWA2</accession>
    <name>A0A8I5MWA2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Interferon alpha 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031510143.1">
        <property type="nucleotide sequence ID" value="XM_031654283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MWA2"/>
    <dbReference type="Ensembl" id="ENSPANT00000078685.1">
        <property type="protein sequence ID" value="ENSPANP00000048482.1"/>
        <property type="gene ID" value="ENSPANG00000050899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116270026"/>
    <dbReference type="KEGG" id="panu:116270026"/>
    <dbReference type="GeneTree" id="ENSGT01000000214430"/>
    <dbReference type="OMA" id="QYCAWEF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00095">
        <property type="entry name" value="IFab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000001">
        <property type="entry name" value="Interferon alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF64">
        <property type="entry name" value="INTERFERON ALPHA-1_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00266">
        <property type="entry name" value="INTERFERONAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00076">
        <property type="entry name" value="IFabd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00252">
        <property type="entry name" value="INTERFERON_A_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3 7" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035198505" description="Interferon alpha 1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21733" checksum="A77919E7B1D078ED" modified="2022-05-25" version="1">MALPFALLMALVVLSSKSSCSLGCDLPETHSLDNRRTMMLLAQMSRISPSSCLMDRHDFGFPQQEFDGNQFQKAPAISVIHELIQQTFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQQERVGETPLMNADSTLAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSFSLSTNLQERLRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N337</accession>
    <name>A0A8I5N337_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F-box only protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FBXO30</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N337"/>
    <dbReference type="Ensembl" id="ENSPANT00000068116.1">
        <property type="protein sequence ID" value="ENSPANP00000053904.1"/>
        <property type="gene ID" value="ENSPANG00000024766.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183204"/>
    <dbReference type="OMA" id="SSWQVKE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22174">
        <property type="entry name" value="F-box_FBXO30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.150:FF:000001">
        <property type="entry name" value="F-box only protein 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF13">
        <property type="entry name" value="F-BOX ONLY PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="13">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057742"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="734" mass="81319" checksum="E6DD792729FF525B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N443</accession>
    <name>A0A8I5N443_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N443"/>
    <dbReference type="Ensembl" id="ENSPANT00000082992.1">
        <property type="protein sequence ID" value="ENSPANP00000047861.1"/>
        <property type="gene ID" value="ENSPANG00000048747.1"/>
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    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="NDWANEE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="901" mass="105963" checksum="DDA4051CFECE301C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7S8</accession>
    <name>A0A8I5N7S8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Butyrophilin subfamily 3 member A2-like Ig-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7S8"/>
    <dbReference type="Ensembl" id="ENSPANT00000079238.1">
        <property type="protein sequence ID" value="ENSPANP00000057091.1"/>
        <property type="gene ID" value="ENSPANG00000043777.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163835"/>
    <dbReference type="OMA" id="FIAICIY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF110">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Butyrophilin subfamily 3 member A2-like Ig-C" evidence="8">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="192" mass="22112" checksum="552FDC7A94A14D34" modified="2022-05-25" version="1">MQSALRHHCLLAEPWYLSPGLDSEPLIEMRDHEDGGIWLECISGGWYLKPLTVWRDPYSEVVPALKEISTPDTEGLFIVTTAVITRDKLVRNVSCSINDTLFGQKKESAIFIPESFMPSRSPCVVILPVIMTILMIFIAICIYWINKLQKEKKICQEKEFEQERKETALKELEKECVEKEKELQIQGKRGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N9Y1</accession>
    <name>A0A8I5N9Y1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sad1 and UNC84 domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUN2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus inner membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N9Y1"/>
    <dbReference type="Ensembl" id="ENSPANT00000063363.1">
        <property type="protein sequence ID" value="ENSPANP00000053435.1"/>
        <property type="gene ID" value="ENSPANG00000020414.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160024"/>
    <dbReference type="OMA" id="WAASCFW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140444">
        <property type="term" value="F:cytoskeleton-nuclear membrane anchor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005521">
        <property type="term" value="F:lamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090292">
        <property type="term" value="P:nuclear matrix anchoring at nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031022">
        <property type="term" value="P:nuclear migration along microfilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021817">
        <property type="term" value="P:nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21438">
        <property type="entry name" value="SUN2_cc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000009">
        <property type="entry name" value="SUN domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040994">
        <property type="entry name" value="Sun_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF22">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18580">
        <property type="entry name" value="HTH_SUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="9">
        <location>
            <begin position="667"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="464"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="857" mass="94002" checksum="475AE7C4677F25D5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NAS9</accession>
    <name>A0A8I5NAS9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Attractin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ATRNL1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in melanocortin signaling pathways that regulate energy homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with MC4R.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017799846.1">
        <property type="nucleotide sequence ID" value="XM_017944357.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000064307.1">
        <property type="protein sequence ID" value="ENSPANP00000058736.1"/>
        <property type="gene ID" value="ENSPANG00000020713.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007583"/>
    <dbReference type="CTD" id="26033"/>
    <dbReference type="GeneTree" id="ENSGT00940000155790"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03597">
        <property type="entry name" value="CLECT_attractin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000860">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000079">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000022">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000116">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000008">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000013">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034011">
        <property type="entry name" value="Attractin-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF4">
        <property type="entry name" value="ATTRACTIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 17" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1229"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="20">
        <location>
            <begin position="92"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="23">
        <location>
            <begin position="754"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="22">
        <location>
            <begin position="1013"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1353"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1378" mass="152607" checksum="6DDD942A4692FDE2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NAX1</accession>
    <name>A0A8I5NAX1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Late cornified envelope 7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LCE7A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NAX1"/>
    <dbReference type="Ensembl" id="ENSPANT00000064609.1">
        <property type="protein sequence ID" value="ENSPANP00000055108.1"/>
        <property type="gene ID" value="ENSPANG00000046986.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00780000122937"/>
    <dbReference type="OMA" id="PRFYLRQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028205">
        <property type="entry name" value="LCE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14672">
        <property type="entry name" value="LCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0417">Keratinization</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="95" mass="10485" checksum="DCAFDDD3C35E3D30" modified="2022-05-25" version="1">MSYQKHQQKWQLPAKCLPKYPSKWAPQAPASCPPPCPPPAPSYCVPSCCISGFGGHCSLVSLRFPRFYLRQPQHSDCCEHESSRCSTCHGSGDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCB4</accession>
    <name>A0A8I5NCB4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCB4"/>
    <dbReference type="Ensembl" id="ENSPANT00000082266.1">
        <property type="protein sequence ID" value="ENSPANP00000051212.1"/>
        <property type="gene ID" value="ENSPANG00000051328.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="YCENTIR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="15">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="14">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="16">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="39605" checksum="23D585AF4836DF76" modified="2022-05-25" version="1">MGKKQGRKAGNSKNKSTSPPAKERSSSPATDQSWTENDFDEMREEGFSPSNFSELKEELRTQRKETKNLEKKVEELTARVINAEKVINEMKEMKTMTREIRDKCISFSNRLNQLEERVSAIEDQMNEMKQEEKPKEKRRKRNEQSLQEVWDYVKRPNLRLIGVPESEGENGTKLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSSRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTADLSAETLQARREWGPIFNILKEKNFKPRISYPAKLSFISEGEIKSFTDKQMLRDFVTTRPALQETLKEALNMERNNRYQPLQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NG79</accession>
    <name>A0A8I5NG79_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NG79"/>
    <dbReference type="Ensembl" id="ENSPANT00000068474.1">
        <property type="protein sequence ID" value="ENSPANP00000051175.1"/>
        <property type="gene ID" value="ENSPANG00000045530.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005569"/>
    <dbReference type="OMA" id="HPGSCDV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF7">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4, Y ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="263" mass="29388" checksum="92B6CEBFDCCC76BA" modified="2022-05-25" version="1">MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIVFLRNRLKYALTGDEVKKICMQRFIKIDGKVRVDVTYPAGFMDVISIEKTGEHFRLVYDTKGRFAVHRITAEEAKYKLCKVRKITVGTKGIPHLVTHDARTIRYPDPVIKVNDTVRIDLGTGKITSFIKFDTGNVCMVIGGANLGRVGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGNGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGL6</accession>
    <name>A0A8I5NGL6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGL6"/>
    <dbReference type="Ensembl" id="ENSPANT00000063735.1">
        <property type="protein sequence ID" value="ENSPANP00000056639.1"/>
        <property type="gene ID" value="ENSPANG00000043719.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF135">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="279" mass="29781" checksum="116B91DB1811F3B5" modified="2022-05-25" version="1">ICFLPLFFFSLFFLFFSFSFSFFFFFFFWRRSLALSPRLEFRGTITAHCNVHLPGSSDSPVSASGVAGTTGVCHHAQLIFVFLVETGFHHVGQAGLELLTSSDPPASTSQSTGITGVSHCAQLSLFLNLTGARGLQGQDGLEANNPGGTRRSPTRLGRQPHGPWADARGAAAQGGERLLGPILKQRNVQSWSLAPGAGRVGAGRAARSGRPFPLDGQPALTQPSDSACVLQRGPRGSFAAVAKPGAAKRWRHRGRELACTPEPSKPRSRCAGGAVRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGT8</accession>
    <name>A0A8I5NGT8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGT8"/>
    <dbReference type="Ensembl" id="ENSPANT00000074020.1">
        <property type="protein sequence ID" value="ENSPANP00000051319.1"/>
        <property type="gene ID" value="ENSPANG00000044353.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000190647"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="80" mass="9032" checksum="E4FDE00DD6E37DFC" modified="2022-05-25" version="1">MMGNMERPVNSMSTRPLLHCICRKVNALVRGNAMWNTMMVDKAFHESTDGSLYRSIVCRIGKPISQVSVYSSEDKPLPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJX3</accession>
    <name>A0A8I5NJX3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Testis expressed 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TEX35</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJX3"/>
    <dbReference type="Ensembl" id="ENSPANT00000073968.1">
        <property type="protein sequence ID" value="ENSPANP00000058140.1"/>
        <property type="gene ID" value="ENSPANG00000005098.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011962"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027874">
        <property type="entry name" value="Tex35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36860">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36860:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15079">
        <property type="entry name" value="Tsc35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="326" mass="36476" checksum="95AC65CC451087D8" modified="2022-05-25" version="1">MVGWGCRGGGRAAGFLCKGQMFSSPVLMPARLNPSLLFWQSKNYKAVCLELKPEPTKVRSSFEAMPAARPEIHGEVTWSQGSFADPSGQDLCQTFDYKAVKQEGRFTKAGVTQDLKNELREVREELKEKMEEIKQIKDLMDKDFDKLHEFVEIMKEMQKDMDEKMDILINTQKNYKLPLRRAPKEQQELRLMGKTHREPQLRPKKMDGTGGANGAPCALHKKTMAPQKKQGSLDPLHECGPCCREIFTPSLGTLFTLGFWSCLLIYLYLNPSDIEYVSNLAQPQNLPAGNLPSEASGLYKGGEEPVTTQPSVGHAAPAPKSQTEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NK31</accession>
    <name>A0A8I5NK31_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">H2BC11</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NK31"/>
    <dbReference type="SMR" id="A0A8I5NK31"/>
    <dbReference type="Ensembl" id="ENSPANT00000081026.1">
        <property type="protein sequence ID" value="ENSPANP00000048555.1"/>
        <property type="gene ID" value="ENSPANG00000038407.1"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101010089"/>
    <dbReference type="GeneTree" id="ENSGT01150000286984"/>
    <dbReference type="OMA" id="HYNKPST"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043505">
        <property type="term" value="C:CENP-A containing nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002227">
        <property type="term" value="P:innate immune response in mucosa"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010804">
        <property type="term" value="P:negative regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="126" mass="13904" checksum="0408C881ABBE6647" modified="2022-05-25" version="1">MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKU6</accession>
    <name>A0A8I5NKU6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">JAK3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKU6"/>
    <dbReference type="Ensembl" id="ENSPANT00000063927.1">
        <property type="protein sequence ID" value="ENSPANP00000058608.1"/>
        <property type="gene ID" value="ENSPANG00000004912.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161827"/>
    <dbReference type="OMA" id="MENQCHG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031234">
        <property type="term" value="C:extrinsic component of cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005131">
        <property type="term" value="F:growth hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060397">
        <property type="term" value="P:growth hormone receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035723">
        <property type="term" value="P:interleukin-15-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038110">
        <property type="term" value="P:interleukin-2-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035771">
        <property type="term" value="P:interleukin-4-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038111">
        <property type="term" value="P:interleukin-7-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038113">
        <property type="term" value="P:interleukin-9-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000329">
        <property type="term" value="P:negative regulation of T-helper 17 cell lineage commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046425">
        <property type="term" value="P:regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10380">
        <property type="entry name" value="SH2_Jak3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000110">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000084">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000135">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041155">
        <property type="entry name" value="FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041046">
        <property type="entry name" value="FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041381">
        <property type="entry name" value="JAK1-3/TYK2_PHL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016251">
        <property type="entry name" value="Tyr_kinase_non-rcpt_Jak/Tyk2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020775">
        <property type="entry name" value="Tyr_kinase_non-rcpt_Jak3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE JAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18379">
        <property type="entry name" value="FERM_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18377">
        <property type="entry name" value="FERM_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17887">
        <property type="entry name" value="Jak1_Phl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21990">
        <property type="entry name" value="SH2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01823">
        <property type="entry name" value="JANUSKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01826">
        <property type="entry name" value="JANUSKINASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="14">
        <location>
            <begin position="67"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="564"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="865"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1225"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1243"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139576" checksum="BFF3ADC52543C1E5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNH3</accession>
    <name>A0A8I5NNH3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurexophilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NXPH4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be signaling molecules that resemble neuropeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the neurexophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906687.2">
        <property type="nucleotide sequence ID" value="XM_003906638.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNH3"/>
    <dbReference type="Ensembl" id="ENSPANT00000063536.1">
        <property type="protein sequence ID" value="ENSPANP00000054921.1"/>
        <property type="gene ID" value="ENSPANG00000042378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101024606"/>
    <dbReference type="KEGG" id="panu:101024606"/>
    <dbReference type="CTD" id="11247"/>
    <dbReference type="GeneTree" id="ENSGT00950000182883"/>
    <dbReference type="OMA" id="TARAWSW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010450">
        <property type="entry name" value="Nxph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17103">
        <property type="entry name" value="NEUREXOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17103:SF10">
        <property type="entry name" value="NEUREXOPHILIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038019">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035185028" description="Neurexophilin" evidence="5">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="305" mass="32859" checksum="73ABB8492E3B6B6A" modified="2022-05-25" version="1">MRLLPEWFLLLFGPWLLKKAVNAQIPESGRPQYLELRPAAAGAGAPGQQLPALRSSDGLGAGRAWSWAWPTNHTAALAQAGAAGALPAQRTKRKPSIKAARAKKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNGTFSVYFRHNSSSLGNLSVSIVPPSKRVEFGGVWLPGPVPHPLQSTLALEGVLPGLGPPLGMAAAAAGPGSFGGALAGPLGGALGVPGAKESRAFNCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPFKVICIFVSFLSFDYKLVQKVCPDYNFQSEHPYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU19</accession>
    <name>A0A8I5NU19_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU19"/>
    <dbReference type="Ensembl" id="ENSPANT00000073212.1">
        <property type="protein sequence ID" value="ENSPANP00000053538.1"/>
        <property type="gene ID" value="ENSPANG00000042345.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="221" mass="24796" checksum="E6C1705B787D1D89" modified="2022-05-25" version="1">MVYCSLYFAGSSDPLTSASAVAGTDYRCMPPRPANFFYYYFCRDGILPHCSGWSQIPAQAICPPQPPKVLGLQGMSHHTQPVCYLFIYLFIYLFMMEFLSVTRLECSDSETIKATIAKLRLLFIFFFRRHLAVSQVGVQWYDLSLVQPPPPEFKQFSCLSLPSSWDYKCASPCLANFCIFIRDQFHYVGHAGLELLTSSDLPTSASQSAGITSVSHCARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUT0</accession>
    <name>A0A8I5NUT0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ciliary microtubule inner protein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CIMIP2B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUT0"/>
    <dbReference type="Ensembl" id="ENSPANT00000082610.1">
        <property type="protein sequence ID" value="ENSPANP00000059584.1"/>
        <property type="gene ID" value="ENSPANG00000025352.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024043"/>
    <dbReference type="CTD" id="730112"/>
    <dbReference type="GeneTree" id="ENSGT00940000154822"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146:SF8">
        <property type="entry name" value="PROTEIN FAM166B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="11">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="11">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="276" mass="30650" checksum="C4DE8779FF1F100A" modified="2022-05-25" version="1">MAVASTFIPGLNPQNPHYIPGYTGHCPLLRFSMGQTYGQVTGQLLRDPPGLAWPPVHRTLLPPIRPPRSPEVPRESLPLRHGHKRLSSSMIPGYTGFVPRAQFIFAKNCSQVWAEALSDFTHLHGKQGSEELPKEAKGRKDTEKDQVPEPEGQLEEQPALEVVEQASPYSMDDRDPRKFTSGFTGYVPRARFLFGSSFPVLSNQALQESGQKHSPGSAQKDPKYLPPLPRTYPQNLGLLPNYGGYVPGYKFQFGHTFGHLTHDALGLSTFQKQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NVI0</accession>
    <name>A0A8I5NVI0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NVI0"/>
    <dbReference type="Ensembl" id="ENSPANT00000075879.1">
        <property type="protein sequence ID" value="ENSPANP00000057218.1"/>
        <property type="gene ID" value="ENSPANG00000048080.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="IMNELPC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
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</entry>
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            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
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    <accession>A0A8I5NXH7</accession>
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        </source>
    </evidence>
    <sequence length="309" mass="34532" checksum="BC368CD649ADD152" modified="2022-05-25" version="1">MDGANDSSLKGFVLMGISDHPQLEMIFFIAIVFSYLLTLLGNSIIILLSCLDAWLHTPMYFFLSNLSSLDLAFTTSSVPQMLINLWGPDKTISYGGCVTQLYVFLWLGATECILLVVMAFDRYVAVCRPLRYTTIMNPQLCWLLAVIAWLGGLDNSVIQSTFTLQLPLCGHWRVESFLCEVPAMIKLACGDTSLNEAVLNGVCTFFTAVPLSIILISYCLTAQAVLKIHSAEGRRKAFNTCLSHLLVVFLFYGSASYGYLLRDKNSNQYQSKFISLFYSVVTPMVNPLIYMLRNMEVKGALRRLLGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXS1</accession>
    <name>A0A8I5NXS1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NXS1"/>
    <dbReference type="Ensembl" id="ENSPANT00000079479.1">
        <property type="protein sequence ID" value="ENSPANP00000061173.1"/>
        <property type="gene ID" value="ENSPANG00000049975.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="OMA" id="MNPAKIR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="134" mass="14625" checksum="CDA9BD13ED1B3D65" modified="2022-05-25" version="1">MNPAKIRPLLFFLFFFLFFFFFFEIVPLLSTRLECSGTISAHCNLHLLGPSNSPASASQVAGITGACHLAWLIFVLLVATGFCHVGQAGLQLLTSGDPPTSASQSAGITGVSYHAQSFFFFFFKWKWGFTCCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NY82</accession>
    <name>A0A8I5NY82_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NY82"/>
    <dbReference type="Ensembl" id="ENSPANT00000023593.3">
        <property type="protein sequence ID" value="ENSPANP00000055866.1"/>
        <property type="gene ID" value="ENSPANG00000002587.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164617"/>
    <dbReference type="OMA" id="NWEDERD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="234" mass="27562" checksum="6EF76C236552D198" modified="2022-05-25" version="1">MAASGESGTSGSGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFELSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTEKERKKQLKKEGKPTIVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKQQREEEIEAQEKAKREREWQKNFEESRDGRVDSWRNFQANTKGKKEKKNRTFLRPPKIKMEQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYB6</accession>
    <name>A0A8I5NYB6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DDX53</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_003917545.1">
        <property type="nucleotide sequence ID" value="XM_003917496.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NYB6"/>
    <dbReference type="Ensembl" id="ENSPANT00000076921.1">
        <property type="protein sequence ID" value="ENSPANP00000055926.1"/>
        <property type="gene ID" value="ENSPANG00000037837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101000964"/>
    <dbReference type="KEGG" id="panu:101000964"/>
    <dbReference type="CTD" id="168400"/>
    <dbReference type="GeneTree" id="ENSGT00940000167221"/>
    <dbReference type="OMA" id="AFQQYPD"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17958">
        <property type="entry name" value="DEADc_DDX43_DDX53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22430">
        <property type="entry name" value="KH-I_DDX43_DDX53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000083">
        <property type="entry name" value="DEAD (Asp-Glu-Ala-Asp) box polypeptide 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="253"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="440"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="632" mass="71381" checksum="498CE9A804A49D2E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P0B2</accession>
    <name>A0A8I5P0B2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HPDL</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003919638.1">
        <property type="nucleotide sequence ID" value="XM_003919589.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P0B2"/>
    <dbReference type="Ensembl" id="ENSPANT00000078070.1">
        <property type="protein sequence ID" value="ENSPANP00000061179.1"/>
        <property type="gene ID" value="ENSPANG00000046630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025203"/>
    <dbReference type="KEGG" id="panu:101025203"/>
    <dbReference type="CTD" id="84842"/>
    <dbReference type="GeneTree" id="ENSGT00530000063474"/>
    <dbReference type="OMA" id="PTLMRWF"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050585">
        <property type="term" value="F:4-hydroxymandelate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF10">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="160"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="381" mass="40318" checksum="6F554973B5A4A1B2" modified="2022-05-25" version="1">MAAPALRLCHIAFHVPAGQPLARDLQHLFGFQPLASREVDGWRQLALRSGDAVFLVNEGPGSGEPLYGLDPRHAVPSATNLCFDVADVGAATRELAALGCSVPVPPVRVGDTQGAATYAVVSSPAGNISLTLLERAGYRGPFLPGFRPVPSAPGPGWVSRVDHLTLACAAGSSPTLLRWFHNCLGFCHLPLSPDEDPELGLEITAGFGLGGLRLTALQAQPGSLVPTLVLAESLPGATTRQDQVEQFLARHKGPGLQHVGLYTPNIVEATERVAAAGGQFLAPPGAYYQQPGKERQIRAAGHEPHLLARQGILLDGDEGKFLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQSVQEQAAKSQEAEGCPELSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZI1</accession>
    <name>A0A8I5QZI1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZI1"/>
    <dbReference type="Ensembl" id="ENSPANT00000071213.1">
        <property type="protein sequence ID" value="ENSPANP00000049258.1"/>
        <property type="gene ID" value="ENSPANG00000037595.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286925"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053179">
        <property type="entry name" value="LINE-1_ORF2_RT/EN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25952">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25952:SF255">
        <property type="entry name" value="LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="197" mass="23149" checksum="46A7EBB6FA9EE222" modified="2022-05-25" version="1">MAILPKVICRFNAVFIKLPLTFFIELEKTILNFIWNQKRACIAKTILSKQNKAGGITLPDFKLYYKATVTKTAWYWYQNRYINQWNRTEASEITPHIYNHLIFDKPDKNKQWGNDSLFNKQCCENWLAIHRKLKLGSLTPYTKINSRWIKDLNRRLLRSCPGPLTAVKHCHPFPSLHFDLLKYHCAGPLLSAVDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R0W8</accession>
    <name>A0A8I5R0W8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
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        <property type="gene ID" value="ENSPANG00000044926.1"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PIN4"/>
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    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="86" mass="9120" checksum="9DDFC6AD429188F3" modified="2022-05-25" version="1">MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVASQYSEDKARQMHSLFRFL</sequence>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
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        <name type="common">Olive baboon</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000046641.1"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="RT_dom"/>
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="681" mass="79798" checksum="E21BBC373E529CD4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8I5R5N5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
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    <dbReference type="Ensembl" id="ENSPANT00000062582.1">
        <property type="protein sequence ID" value="ENSPANP00000049913.1"/>
        <property type="gene ID" value="ENSPANG00000044698.1"/>
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    <dbReference type="GeneTree" id="ENSGT00670000098165"/>
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        <property type="component" value="Chromosome 20"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
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    <dbReference type="Gene3D" id="2.30.30.10">
        <property type="entry name" value="Integrase, C-terminal domain superfamily, retroviral"/>
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    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
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    <dbReference type="InterPro" id="IPR036862">
        <property type="entry name" value="Integrase_C_dom_sf_retrovir"/>
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    <dbReference type="InterPro" id="IPR001037">
        <property type="entry name" value="Integrase_C_retrovir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003308">
        <property type="entry name" value="Integrase_Zn-bd_dom_N"/>
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    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
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    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="RT_dom"/>
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    <dbReference type="InterPro" id="IPR010661">
        <property type="entry name" value="RVT_thumb"/>
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        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN"/>
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        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02022">
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    <dbReference type="SUPFAM" id="SSF53098">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50876">
        <property type="entry name" value="ZF_INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="15">
        <location>
            <begin position="364"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase-type" evidence="13">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="553"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase-type" evidence="17">
        <location>
            <begin position="718"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Integrase-type" evidence="12">
        <location>
            <begin position="718"/>
            <end position="767"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00506"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
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        <source>
            <dbReference type="PROSITE" id="PS51027"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049913.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R947</accession>
    <name>A0A8I5R947_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSPANP00000058077.1"/>
        <property type="gene ID" value="ENSPANG00000045994.1"/>
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    <dbReference type="GeneTree" id="ENSGT01050000248429"/>
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        <property type="component" value="Chromosome 16"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="84" mass="9190" checksum="3296E37B9A4B23E5" modified="2022-05-25" version="1">VPRPRGCGCCRACPCDGSLVSQPVSFLPRADLPFLRESGRWCRLSWLLWGSQGTAITPLRQWVWAAPLATLDLSVFASSLGMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A9L8W4</accession>
    <name>A9L8W4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Matrix metallopeptidase 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">MMP26</name>
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    <organism evidence="12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
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                <person name="Maduro V.B."/>
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                <person name="Masiello C."/>
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                <person name="Prasad A."/>
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                <person name="Riebow N."/>
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                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
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                <person name="Babu C.B."/>
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                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000505">
        <property type="protein sequence ID" value="ABX52125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162305.1">
        <property type="nucleotide sequence ID" value="NM_001168834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9L8W4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002304"/>
    <dbReference type="MEROPS" id="M10.029"/>
    <dbReference type="Ensembl" id="ENSPANT00000001414.3">
        <property type="protein sequence ID" value="ENSPANP00000002304.1"/>
        <property type="gene ID" value="ENSPANG00000016290.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137297"/>
    <dbReference type="KEGG" id="panu:100137297"/>
    <dbReference type="CTD" id="56547"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163719"/>
    <dbReference type="HOGENOM" id="CLU_015489_4_1_1"/>
    <dbReference type="OMA" id="FLPWCFT"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000052">
        <property type="entry name" value="Matrix metallopeptidase 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF76">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015086755" evidence="10">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="11">
        <location>
            <begin position="95"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABX52125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="261" mass="29989" checksum="EE57409D2133C4E4" modified="2008-02-05" version="1">MQLVILRVTIFLPWCFALPVPPATVHKGWDFVKDYFHQFFLTKKESPLLTQETQIQLLQQFHRNGTGRLDMQMHAMLHQPRCGVPDESNTSISPGRCKWNKYTLTYRIINYPHDMKPSTVKDSIYNAVSIWSNVTPLIFQQVQNEDADIKISFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSTSNTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPGTFQLSADDIQRIQHLYGEKCSSDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A9L906</accession>
    <accession>A0A0A0MWT1</accession>
    <name>A9L906_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">TCF3 fusion partner</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">TFPT</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2007-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DP000506">
        <property type="protein sequence ID" value="ABX52169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162343.1">
        <property type="nucleotide sequence ID" value="NM_001168872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9L906"/>
    <dbReference type="SMR" id="A9L906"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010324"/>
    <dbReference type="Ensembl" id="ENSPANT00000006008.3">
        <property type="protein sequence ID" value="ENSPANP00000010324.3"/>
        <property type="gene ID" value="ENSPANG00000012505.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137335"/>
    <dbReference type="KEGG" id="panu:100137335"/>
    <dbReference type="CTD" id="29844"/>
    <dbReference type="eggNOG" id="ENOG502RHUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016605"/>
    <dbReference type="HOGENOM" id="CLU_096140_0_0_1"/>
    <dbReference type="OMA" id="WRCKEIE"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012505">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904507">
        <property type="term" value="P:positive regulation of telomere maintenance in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060382">
        <property type="term" value="P:regulation of DNA strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033555">
        <property type="entry name" value="TFPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084:SF1">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABX52169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010324.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="253" mass="28225" checksum="D12BF90669E27A36" modified="2008-02-05" version="1">MELEQREGTMAAVGFEEFSAPPGSELALPPLFGGHILESELETEVEFVSGGLGGSGLRERDEEEEAARGRRRRQRELNRRKYQALGRRCREIEQVNERVLNRLHQVQRITRRLQQERRFLMRVLDSYGDDYRASQFTIVLEDEGSQGTDAPTPGNAENEPPEKEALSPPRRTPAPPEPGSPAPGEGPSGRKRRRVPRDGRRAGTALTPELASVQIKVEEDFGFEADEALDSSWVSRGPDKLLPYPTLASPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKK7</accession>
    <name>A0A096MKK7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calpain-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">PalB homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CAPN7</name>
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    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Calcium-regulated non-lysosomal thiol-protease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895181.1">
        <property type="nucleotide sequence ID" value="XM_003895132.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKK7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000022"/>
    <dbReference type="MEROPS" id="C02.029"/>
    <dbReference type="Ensembl" id="ENSPANT00000002004.3">
        <property type="protein sequence ID" value="ENSPANP00000000022.1"/>
        <property type="gene ID" value="ENSPANG00000007740.3"/>
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    <dbReference type="GeneID" id="101014952"/>
    <dbReference type="KEGG" id="panu:101014952"/>
    <dbReference type="CTD" id="23473"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155892"/>
    <dbReference type="HOGENOM" id="CLU_006770_2_0_1"/>
    <dbReference type="OMA" id="GDYRRGC"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007740">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MKK7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090541">
        <property type="term" value="F:MIT domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097264">
        <property type="term" value="P:self proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02681">
        <property type="entry name" value="MIT_calpain7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000016">
        <property type="entry name" value="Calpain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000007">
        <property type="entry name" value="Calpain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000008">
        <property type="entry name" value="Calpain 7"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.70.10:FF:000069">
        <property type="entry name" value="Calpain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
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    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
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    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 14" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="15">
        <location>
            <begin position="249"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 14">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 14">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 14">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="813" mass="92769" checksum="EB122269F7CC263C" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MME4</accession>
    <name>A0A096MME4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor binding to IGHM enhancer 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TFE3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021788555.2">
        <property type="nucleotide sequence ID" value="XM_021932863.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MME4"/>
    <dbReference type="SMR" id="A0A096MME4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000770"/>
    <dbReference type="Ensembl" id="ENSPANT00000004278.3">
        <property type="protein sequence ID" value="ENSPANP00000000770.3"/>
        <property type="gene ID" value="ENSPANG00000013676.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015372"/>
    <dbReference type="KEGG" id="panu:101015372"/>
    <dbReference type="CTD" id="7030"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157503"/>
    <dbReference type="HOGENOM" id="CLU_031638_1_1_1"/>
    <dbReference type="OMA" id="ATFHAGE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013676">
        <property type="expression patterns" value="Expressed in iris and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045670">
        <property type="term" value="P:regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18928">
        <property type="entry name" value="bHLHzip_TFE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000003">
        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024100">
        <property type="entry name" value="bHLHzip_TFE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021802">
        <property type="entry name" value="MiT/TFE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000770.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="575" mass="61547" checksum="1633ED657B04E758" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNY0</accession>
    <name>A0A096MNY0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome RNA helicase MTR4</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Superkiller viralicidic activity 2-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">TRAMP-like complex helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">MTREX</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003899726.2">
        <property type="nucleotide sequence ID" value="XM_003899677.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNY0"/>
    <dbReference type="Ensembl" id="ENSPANT00000005970.3">
        <property type="protein sequence ID" value="ENSPANP00000001404.2"/>
        <property type="gene ID" value="ENSPANG00000009697.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024675"/>
    <dbReference type="KEGG" id="panu:101024675"/>
    <dbReference type="CTD" id="23517"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156183"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009697">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MNY0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000004">
        <property type="entry name" value="Superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="148"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="26">
        <location>
            <begin position="405"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117878" checksum="53367A1FD226539B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQ13</accession>
    <name>A0A096MQ13_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Shisa family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SHISA2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009189925.1">
        <property type="nucleotide sequence ID" value="XM_009191661.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQ13"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001835"/>
    <dbReference type="Ensembl" id="ENSPANT00000011175.3">
        <property type="protein sequence ID" value="ENSPANP00000001835.1"/>
        <property type="gene ID" value="ENSPANG00000002307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023486"/>
    <dbReference type="KEGG" id="panu:101023486"/>
    <dbReference type="CTD" id="387914"/>
    <dbReference type="eggNOG" id="ENOG502QWT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157443"/>
    <dbReference type="HOGENOM" id="CLU_085916_0_0_1"/>
    <dbReference type="OMA" id="YAHPVSP"/>
    <dbReference type="OrthoDB" id="10025410at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002307">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF0">
        <property type="entry name" value="PROTEIN SHISA-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001927398" evidence="7">
        <location>
            <begin position="34"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="295" mass="31285" checksum="779E5199B588548E" modified="2014-11-26" version="1">MWGGRRSSVASSRNAASLLQLLLAALLAAGARASGEYCHGWLDAQGVWRIGFQCPERFDGGDATICCGSCALRYCCSSAEARLDQGGCDNDRQQGAGEPGRADKDGPDGSAVPIYVPFLIVGSVFVAFIILGSLVAACCCRCLRPKQDPQQSRAPGGNRLMETIPMIPSASTSRGSSSRQSSTAASSSSSANSGARAPPTRSQTNCCLPEGTMNNVYVNMPTNFSVLNCQQATQIVPHQGQYLHPPYVGYAVQHDSVPMTAVPPFMDGLQPGYRQIQSPFPHTNSEQKMYPAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQF4</accession>
    <name>A0A096MQF4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ULK1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Serine/threonine-protein kinase involved in autophagy in response to starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031506800.1">
        <property type="nucleotide sequence ID" value="XM_031650940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQF4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001981"/>
    <dbReference type="Ensembl" id="ENSPANT00000014100.3">
        <property type="protein sequence ID" value="ENSPANP00000001981.3"/>
        <property type="gene ID" value="ENSPANG00000000375.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010161"/>
    <dbReference type="CTD" id="8408"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156664"/>
    <dbReference type="HOGENOM" id="CLU_011264_0_0_1"/>
    <dbReference type="OMA" id="PQPHQIT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000375">
        <property type="expression patterns" value="Expressed in aorta and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903349">
        <property type="term" value="C:omegasome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048671">
        <property type="term" value="P:negative regulation of collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14202">
        <property type="entry name" value="STKc_ULK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000128">
        <property type="entry name" value="serine/threonine-protein kinase ULK2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000149">
        <property type="entry name" value="serine/threonine-protein kinase unc-51 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016237">
        <property type="entry name" value="Ser/Thr_kin_STPK_Ulk-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF19">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000580">
        <property type="entry name" value="Ser/Thr_PK_STPK_ULK-1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001981.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1049" mass="112522" checksum="5E8009184282938B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQZ7</accession>
    <name>A0A096MQZ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase 1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PPP1R3D</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003904588.1">
        <property type="nucleotide sequence ID" value="XM_003904539.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQZ7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002183"/>
    <dbReference type="Ensembl" id="ENSPANT00000004413.3">
        <property type="protein sequence ID" value="ENSPANP00000002183.1"/>
        <property type="gene ID" value="ENSPANG00000018275.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002141"/>
    <dbReference type="KEGG" id="panu:101002141"/>
    <dbReference type="CTD" id="5509"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161921"/>
    <dbReference type="HOGENOM" id="CLU_040215_0_1_1"/>
    <dbReference type="OMA" id="CLEQVVC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018275">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2440:FF:000002">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017434">
        <property type="entry name" value="Pase-1_reg-su_3B/C/D_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038207">
        <property type="entry name" value="PP1_GT_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="6">
        <location>
            <begin position="169"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="299" mass="32692" checksum="E4B14A848EBA4F44" modified="2014-11-26" version="1">MSRGPSSAVLPSALGSRKLTPRSLSCLSDLDGGVALEPRPCRPPGSPGRAPPPAPAPSGCDPRLRPIILRRARSLPSSPERRQKAAGAPGAACRPGCSRQLRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLQCLVPDFPPPVEAADFGERLQRQLVCLERVTCSDLGISGTVRVCNVAFEKQVAVRYTFSGWRSTHEAVARWRGPAGPEGKEDVFTFGFPVPPFLLELGSRVHFAVRYRVAGAEYWDNNDRRDYSLTCRNHALHMPRGECEESWIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MSJ4</accession>
    <name>A0A096MSJ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DOLK</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096MSJ4"/>
    <dbReference type="Ensembl" id="ENSPANT00000018028.3">
        <property type="protein sequence ID" value="ENSPANP00000002763.2"/>
        <property type="gene ID" value="ENSPANG00000003223.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004067"/>
    <dbReference type="HOGENOM" id="CLU_027611_2_1_1"/>
    <dbReference type="OMA" id="SWLAYHC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002763.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="570" mass="63492" checksum="6F62D4F64C5460F4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUM5</accession>
    <name>A0A096MUM5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SIAH2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003895003.1">
        <property type="nucleotide sequence ID" value="XM_003894954.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MUM5"/>
    <dbReference type="SMR" id="A0A096MUM5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003541"/>
    <dbReference type="Ensembl" id="ENSPANT00000013914.3">
        <property type="protein sequence ID" value="ENSPANP00000003541.2"/>
        <property type="gene ID" value="ENSPANG00000012916.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020643"/>
    <dbReference type="KEGG" id="panu:101020643"/>
    <dbReference type="CTD" id="6478"/>
    <dbReference type="eggNOG" id="KOG3002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159812"/>
    <dbReference type="HOGENOM" id="CLU_028215_0_2_1"/>
    <dbReference type="OMA" id="AGHLVCK"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012916">
        <property type="expression patterns" value="Expressed in adrenal medulla and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990000">
        <property type="term" value="P:amyloid fibril formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16752">
        <property type="entry name" value="RING-HC_SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000665">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000050">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000063">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="19">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003541.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="324" mass="34615" checksum="2D5DD845666EC924" modified="2018-02-28" version="2">MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWP6</accession>
    <name>A0A096MWP6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum resident protein 27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inactive protein disulfide-isomerase 27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERP27</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with PDIA3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906102.1">
        <property type="nucleotide sequence ID" value="XM_003906053.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWP6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004304"/>
    <dbReference type="Ensembl" id="ENSPANT00000017906.3">
        <property type="protein sequence ID" value="ENSPANP00000004304.1"/>
        <property type="gene ID" value="ENSPANG00000016163.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016226"/>
    <dbReference type="KEGG" id="panu:101016226"/>
    <dbReference type="CTD" id="121506"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151058"/>
    <dbReference type="HOGENOM" id="CLU_088451_0_0_1"/>
    <dbReference type="OMA" id="EESHGYK"/>
    <dbReference type="OrthoDB" id="8667660at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016163">
        <property type="expression patterns" value="Expressed in pancreas and 35 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWP6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000212">
        <property type="entry name" value="Endoplasmic reticulum resident protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000232">
        <property type="entry name" value="Endoplasmic reticulum resident protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF193">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001921943" description="Endoplasmic reticulum resident protein 27" evidence="11">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="273" mass="30650" checksum="B191351506F1223F" modified="2014-11-26" version="1">MEAALSRFMFFLFLLTCDLTAEAAAEVEKSADGPGAAQEPTWLADVPAAMEFIAATEVAVIGFFQDLEIPAVSILRSMVQKFPDVSFGISTDSEVLIHYNITGNTICLFRLVDNEQLNLEDEDTESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDSGMKANGKVISFFKLKESQLPALAIYRTLDDEWDTLPKVEVSIEHVQNFCDGFLSGKLLKENRESEEKTPKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZ75</accession>
    <name>A0A096MZ75_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SLAM family member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLAMF9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MZ75"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005270"/>
    <dbReference type="Ensembl" id="ENSPANT00000023053.4">
        <property type="protein sequence ID" value="ENSPANP00000005270.3"/>
        <property type="gene ID" value="ENSPANG00000022213.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234540"/>
    <dbReference type="HOGENOM" id="CLU_069386_3_1_1"/>
    <dbReference type="OMA" id="CRANNPI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022213">
        <property type="expression patterns" value="Expressed in spleen and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZ75">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16842">
        <property type="entry name" value="Ig_SLAM-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000820">
        <property type="entry name" value="SLAM family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF18">
        <property type="entry name" value="SLAM FAMILY MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035202251" evidence="13">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005270.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="288" mass="31873" checksum="E5BEBE6F42E780DC" modified="2022-05-25" version="3">MCAFTWLLLLLLLQEAKGDSGDGVDPEEVVAVLHESISLPLEIPPKEEVENIIWSSHKSLATVVPGKEGHPATIMVINPHYQGRVSFLDPSYSLHISNLSWEDSGLYQAQVNLRTSQTSTMQQYNLRVYRRLSEPQITVNFEISGEGACNMSLVCSVEKAGMDVTYSWLSSGDSAYTSHEGPVLSTSWRPEDNALSYTCRASNPVSNVSSHPIPAGSFCADPNYASEKPSTAFCLLAKGLLVLLLLVILATVLWVIRVQKRREMPRMKKLKRNRMKLRKKAKPASSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZE2</accession>
    <name>A0A096MZE2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SAAL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein saal1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Synoviocyte proliferation-associated in collagen-induced arthritis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SAAL1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SAAL1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MZE2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005340"/>
    <dbReference type="Ensembl" id="ENSPANT00000015352.3">
        <property type="protein sequence ID" value="ENSPANP00000005340.2"/>
        <property type="gene ID" value="ENSPANG00000006539.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004737"/>
    <dbReference type="HOGENOM" id="CLU_045694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006539">
        <property type="expression patterns" value="Expressed in axillary lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZE2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901647">
        <property type="term" value="P:positive regulation of synoviocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000298">
        <property type="entry name" value="Serum amyloid A like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF23">
        <property type="entry name" value="PROTEIN SAAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005340.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="475" mass="53706" checksum="BDD024D5C8356EEC" modified="2022-05-25" version="2">MDRNPSPPPPGRDQEEEEVAGGDCIGSTVYSKHWLFGVLSGLIQIVSPENTKSSSDDEEQQTELDEEMENEICRVWDMSMDEDVALFLQEFNAPDIFMGVLAKSKCPRLREICVGILGNMACFQEICVSISSDKNLGQVLLHCLYDSDPPTLLETSRLLLTCLSQAEVASVWVERIREHPAIYDSICFIMSSSTNVDLLVKVGEVVDKLFDLDEKLMLEWVRNGATQPLDQPQEESEEQPVFRLVPCILEAAKQVRSENPEWLDVYMHILQLLTTVDDGIQAIVHCPDTGKDIWNLLFDLVCHEFCQSDDPPIILQEQKTVLASVFSVLSAIYASQTEQEYLKIEKGKYNLPLIDSLIRVLQNMEQCQKKPENSTESNTEETKKTDLTQDDFHLKILKDILCEFLSNIFQALTKETVAQGVKEGQLSKQKCSSAFQNLLPFYSPVVEDFIKILHEVDKALADDLEKSFPSLKVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZM8</accession>
    <name>A0A096MZM8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cohesin subunit SA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">SCC3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Stromal antigen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">STAG2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021788610.2">
        <property type="nucleotide sequence ID" value="XM_021932918.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788612.2">
        <property type="nucleotide sequence ID" value="XM_021932920.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788614.2">
        <property type="nucleotide sequence ID" value="XM_021932922.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788615.2">
        <property type="nucleotide sequence ID" value="XM_021932923.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788616.2">
        <property type="nucleotide sequence ID" value="XM_021932924.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788617.2">
        <property type="nucleotide sequence ID" value="XM_021932925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZM8"/>
    <dbReference type="SMR" id="A0A096MZM8"/>
    <dbReference type="Ensembl" id="ENSPANT00000009689.3">
        <property type="protein sequence ID" value="ENSPANP00000005434.3"/>
        <property type="gene ID" value="ENSPANG00000013929.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024103"/>
    <dbReference type="KEGG" id="panu:101024103"/>
    <dbReference type="CTD" id="10735"/>
    <dbReference type="eggNOG" id="KOG2011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182972"/>
    <dbReference type="HOGENOM" id="CLU_005067_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013929">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZM8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF3">
        <property type="entry name" value="COHESIN SUBUNIT SA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="6">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005434.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1268" mass="145735" checksum="26772FFABD05F630" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZS2</accession>
    <name>A0A096MZS2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="19">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FKBP4</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="19"/>
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        <property type="nucleotide sequence ID" value="XM_003919523.4"/>
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    <dbReference type="AlphaFoldDB" id="A0A096MZS2"/>
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    <dbReference type="Ensembl" id="ENSPANT00000005825.3">
        <property type="protein sequence ID" value="ENSPANP00000005479.2"/>
        <property type="gene ID" value="ENSPANG00000010527.3"/>
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    <dbReference type="GeneID" id="101024951"/>
    <dbReference type="KEGG" id="panu:101024951"/>
    <dbReference type="CTD" id="2288"/>
    <dbReference type="eggNOG" id="KOG0543">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157200"/>
    <dbReference type="HOGENOM" id="CLU_013615_13_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="Bgee" id="ENSPANG00000010527">
        <property type="expression patterns" value="Expressed in cerebellum and 65 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A096MZS2">
        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:FK506 binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:heat shock protein binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
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    <dbReference type="InterPro" id="IPR011990">
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    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 19" id="KW-0697">Rotamase</keyword>
    <keyword evidence="11 20" id="KW-0802">TPR repeat</keyword>
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            <begin position="50"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="21">
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            <begin position="1"/>
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            <begin position="434"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50059"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
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    </evidence>
    <sequence length="459" mass="51760" checksum="82F661D0A5F83EEA" modified="2018-02-28" version="2">MTAEEMKATESGAQSAPLPIEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPSATLVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEGYAKPNEGAIVEVALEGYYKDQLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSSEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0J3</accession>
    <name>A0A096N0J3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ciliary neurotrophic factor</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">E3 ubiquitin-protein ligase ZFP91</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">RING-type E3 ubiquitin transferase ZFP91</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Zinc finger protein 91 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">ZFP91</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.</text>
    </comment>
    <comment type="function">
        <text evidence="22">CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Interacts with MAP3K14/NIK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CNTF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A096N0J3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005780"/>
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        <property type="protein sequence ID" value="ENSPANP00000005780.2"/>
        <property type="gene ID" value="ENSPANG00000010800.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156393"/>
    <dbReference type="HOGENOM" id="CLU_034557_0_0_1"/>
    <dbReference type="OMA" id="YCSGAER"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010800">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0J3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005127">
        <property type="term" value="F:ciliary neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048143">
        <property type="term" value="P:astrocyte activation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070120">
        <property type="term" value="P:ciliary neurotrophic factor-mediated signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000022">
        <property type="entry name" value="ciliary neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000183">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000356">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000151">
        <property type="entry name" value="Ciliary_neurotrophic_fac_CNTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15196">
        <property type="entry name" value="CILIARY NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15196:SF0">
        <property type="entry name" value="CILIARY NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01110">
        <property type="entry name" value="CNTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0221">Differentiation</keyword>
    <keyword evidence="20" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15 28" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="29">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00025427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00054990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00065249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00071305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005780.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="687" mass="77507" checksum="E82156D61EAB2FE0" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1S9</accession>
    <name>A0A096N1S9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CSL-type zinc finger-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DPH3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase. Interacts with SERGEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895196.1">
        <property type="nucleotide sequence ID" value="XM_003895147.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1S9"/>
    <dbReference type="SMR" id="A0A096N1S9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006266"/>
    <dbReference type="Ensembl" id="ENSPANT00000009853.3">
        <property type="protein sequence ID" value="ENSPANP00000006266.1"/>
        <property type="gene ID" value="ENSPANG00000012596.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021206"/>
    <dbReference type="KEGG" id="panu:101021206"/>
    <dbReference type="CTD" id="285381"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007225"/>
    <dbReference type="HOGENOM" id="CLU_155991_3_0_1"/>
    <dbReference type="OMA" id="IYDPDMF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012596">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1S9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="82" mass="9240" checksum="7AC8F3FFF8CE766C" modified="2014-11-26" version="1">MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFSITKEDLENGEDVATCPSCSLIIKVIYDKDQFVCGETVPAPSANKELVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1Z9</accession>
    <name>A0A096N1Z9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome binding factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RBFA</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003914570.3">
        <property type="nucleotide sequence ID" value="XM_003914521.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1Z9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006340"/>
    <dbReference type="Ensembl" id="ENSPANT00000013069.3">
        <property type="protein sequence ID" value="ENSPANP00000006340.1"/>
        <property type="gene ID" value="ENSPANG00000009263.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001523"/>
    <dbReference type="KEGG" id="panu:101001523"/>
    <dbReference type="CTD" id="79863"/>
    <dbReference type="eggNOG" id="KOG4700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011362"/>
    <dbReference type="HOGENOM" id="CLU_067827_0_0_1"/>
    <dbReference type="OMA" id="HCSRRLC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009263">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1Z9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
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    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
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    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="341" mass="37926" checksum="E5C3FF00F6244C34" modified="2014-11-26" version="1">MWAVAGGLWGSRAGLRGLLRSPYAALLPGCARGVHGSAVLCKNWLKKFASKTKKKFWYEGPSLGSHLTYKPSKLELLMKTTSKKTRKEDHVRVRALNGLLYKALTDLLCTPEVSQELYDLNVELSKVSLTPDFSACRVYWKTTLSAEQNAHMEAVLQRSAASMRHLLMSQQTMRNVPPIVFVKDKKSAALAELDKLLAVADFGPRDERDDFVQNDFRDADAPQSCGTTEPAPSVCGINHEALNKQIMEYKRRKDKGLGGLVWQGQVAELTTQMKKGRKRARRRLEQDSSLKSYLSGEEVEDDPDLVGAPEYECYALDTEELEAEKGGGTTEDGHGCNASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2A8</accession>
    <name>A0A096N2A8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Interleukin-5 receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">IL5RA</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with IL5. Interacts with CSF2RB. Interacts with JAK2. Interacts with SDCBP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N2A8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006451"/>
    <dbReference type="Ensembl" id="ENSPANT00000023436.3">
        <property type="protein sequence ID" value="ENSPANP00000006451.2"/>
        <property type="gene ID" value="ENSPANG00000011489.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QZNV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160890"/>
    <dbReference type="HOGENOM" id="CLU_039945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011489">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000741">
        <property type="entry name" value="Interleukin 5 receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000755">
        <property type="entry name" value="Interleukin 5 receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000818">
        <property type="entry name" value="Interleukin 5 receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003532">
        <property type="entry name" value="Short_hematopoietin_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015321">
        <property type="entry name" value="TypeI_recpt_CBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF46">
        <property type="entry name" value="INTERLEUKIN 5 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09240">
        <property type="entry name" value="IL6Ra-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01356">
        <property type="entry name" value="HEMATOPO_REC_S_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014130062" description="Interleukin-5 receptor subunit alpha" evidence="15">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Type I cytokine receptor cytokine-binding" evidence="16">
        <location>
            <begin position="131"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006451.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="420" mass="47615" checksum="8075915E6156E320" modified="2018-02-28" version="2">MIIMAPVLLILLGATEILQADLLPDDKISLLPPVNFTIKVTGLAQVLLRWEPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSVVNLTCTTNTTADNYSHLRPYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDSTGRNIACWFPRTFIHSRGRDRLAVLVNGSSKHSAIKPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNARNGYLQIEKMMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGKDEHKPLREWFLIVLMATICFILLILLLICRICHLWIKLFPPIPAPKSNIKDLFVTANYEKAGSVETEIEVISYIEKPGVETLEDSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2N1</accession>
    <name>A0A096N2N1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin-17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Liver-intestine cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CDH17</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
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                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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            <authorList>
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    <sequence length="832" mass="92141" checksum="756646A1BA2D3E5C" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N4Q1</accession>
    <name>A0A096N4Q1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small integral membrane protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMIM10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <submittedName>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="nucleotide sequence ID" value="XM_021938233.2"/>
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        <property type="project" value="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096N7B3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008414"/>
    <dbReference type="Ensembl" id="ENSPANT00000011510.3">
        <property type="protein sequence ID" value="ENSPANP00000008414.1"/>
        <property type="gene ID" value="ENSPANG00000003885.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022731"/>
    <dbReference type="KEGG" id="panu:101022731"/>
    <dbReference type="CTD" id="388701"/>
    <dbReference type="eggNOG" id="ENOG502SF03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048901"/>
    <dbReference type="HOGENOM" id="CLU_2290739_0_0_1"/>
    <dbReference type="OMA" id="WRNAHTD"/>
    <dbReference type="OrthoDB" id="2122938at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003885">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029375">
        <property type="entry name" value="CFAP141"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35818">
        <property type="entry name" value="C1ORF189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35818:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15104">
        <property type="entry name" value="CFAP141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="101" mass="12233" checksum="3E0321F3F22ED524" modified="2014-11-26" version="1">MSVEKMTKVEESFQRAMGLKKMVDRWRNSHTHCLWQMTLGQRRNPYATLRMQDTMVQELALAKKQLLMVRQAALHQLFEKEHQQYQQELNQMGKAFYIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9D7</accession>
    <name>A0A096N9D7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase inhibitor 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PI15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017817605.1">
        <property type="nucleotide sequence ID" value="XM_017962116.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017817606.1">
        <property type="nucleotide sequence ID" value="XM_017962117.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021798142.1">
        <property type="nucleotide sequence ID" value="XM_021942450.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N9D7"/>
    <dbReference type="SMR" id="A0A096N9D7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000038149"/>
    <dbReference type="Ensembl" id="ENSPANT00000025102.3">
        <property type="protein sequence ID" value="ENSPANP00000009254.1"/>
        <property type="gene ID" value="ENSPANG00000001259.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999593"/>
    <dbReference type="KEGG" id="panu:100999593"/>
    <dbReference type="CTD" id="51050"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158635"/>
    <dbReference type="HOGENOM" id="CLU_035730_2_2_1"/>
    <dbReference type="OMA" id="QLVQPWY"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001259">
        <property type="expression patterns" value="Expressed in urinary bladder and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18814">
        <property type="entry name" value="CAP_PI15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000003">
        <property type="entry name" value="Peptidase inhibitor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047832">
        <property type="entry name" value="PI15_CAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="258" mass="29095" checksum="1564A5831336795F" modified="2014-11-26" version="1">MIAISTVSSALLFSLLCEASTVVLLNSTDSSPPTNNFTDIEAALKAQLDSADIPKARRKRYISQNDMIAILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKPWYDEVKDYAFPYPQDCNPRCPMRCFGPMCTHYTQMVWATSNRIGCAIHTCQNMNVWGSVWRRAVYLVCNYAPKGNWIGEAPYKVGVPCSSCPPSYGGSCTDNLCFPGVTSNYLYWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9F0</accession>
    <name>A0A096N9F0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fibroblast growth factor</fullName>
            <shortName evidence="10">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FGF5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898759.1">
        <property type="nucleotide sequence ID" value="XM_003898710.4"/>
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    <dbReference type="SMR" id="A0A096N9F0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009267"/>
    <dbReference type="Ensembl" id="ENSPANT00000008763.3">
        <property type="protein sequence ID" value="ENSPANP00000009267.1"/>
        <property type="gene ID" value="ENSPANG00000012555.3"/>
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    <dbReference type="GeneID" id="101024074"/>
    <dbReference type="KEGG" id="panu:101024074"/>
    <dbReference type="CTD" id="2250"/>
    <dbReference type="eggNOG" id="KOG3885">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158449"/>
    <dbReference type="HOGENOM" id="CLU_081609_7_0_1"/>
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    <dbReference type="OrthoDB" id="9947297at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="expression patterns" value="Expressed in cerebellum and 4 other cell types or tissues"/>
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        <property type="term" value="F:fibroblast growth factor receptor binding"/>
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        <property type="term" value="F:growth factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
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        <property type="term" value="P:glial cell differentiation"/>
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        <property type="term" value="P:positive regulation of cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
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        <property type="entry name" value="beta-trefoil_FGF5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibroblast_GF_fam"/>
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    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-0497">Mitogen</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005107966" description="Fibroblast growth factor" evidence="10">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="268" mass="29636" checksum="F2B10A34A71844BE" modified="2014-11-26" version="1">MSLSFLLLLFFSHLILNAWAHGEKRLVPKGQLGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSILEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKVPLSAPRKNTNTVKYRLKFRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NB00</accession>
    <name>A0A096NB00_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FA complementation group A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FANCA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="9555.ENSPANP00000009906"/>
    <dbReference type="Ensembl" id="ENSPANT00000024279.3">
        <property type="protein sequence ID" value="ENSPANP00000009906.3"/>
        <property type="gene ID" value="ENSPANG00000008150.3"/>
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    <dbReference type="eggNOG" id="ENOG502QT8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007852"/>
    <dbReference type="HOGENOM" id="CLU_005268_0_0_1"/>
    <dbReference type="OMA" id="AIPHCPA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008150">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NB00">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000348">
        <property type="term" value="P:regulation of CD40 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905936">
        <property type="term" value="P:regulation of germ cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045589">
        <property type="term" value="P:regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003516">
        <property type="entry name" value="FANCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055387">
        <property type="entry name" value="FANCA_arcN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055386">
        <property type="entry name" value="FANCA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055277">
        <property type="entry name" value="Fanconi_A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031729">
        <property type="entry name" value="Fanconi_A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12047">
        <property type="entry name" value="FANCONI ANEMIA GROUP A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12047:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24783">
        <property type="entry name" value="FANCA_arcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03511">
        <property type="entry name" value="FANCA_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24781">
        <property type="entry name" value="FANCA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15865">
        <property type="entry name" value="Fanconi_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00826">
        <property type="entry name" value="FANCONIAGENE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anaemia group A protein N-terminal" evidence="2">
        <location>
            <begin position="237"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein helical" evidence="3">
        <location>
            <begin position="516"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein arcN subdomain" evidence="4">
        <location>
            <begin position="620"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein C-terminal" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009906.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1427" mass="158846" checksum="1E2F4159FE787421" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NB26</accession>
    <name>A0A096NB26_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4E binding protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NB26"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009933"/>
    <dbReference type="Ensembl" id="ENSPANT00000007179.3">
        <property type="protein sequence ID" value="ENSPANP00000009933.3"/>
        <property type="gene ID" value="ENSPANG00000021392.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S44S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155342"/>
    <dbReference type="HOGENOM" id="CLU_111706_0_0_1"/>
    <dbReference type="OMA" id="FPTHTVV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009933.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14319" checksum="564368644AA17AAD" modified="2022-05-25" version="3">MSSSAGSGHPPSQSRAFPTHTVVISYAAQLPHDHCTTPEGTLFSTTPGGTRIIYDRKFLLDLRSSPMARTPPCHLPNIPGVTSPGTLSEGSKVEVSNLNNPDKKHAVGGGASWRWTSDSPARIRRKAATGTPECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NB29</accession>
    <name>A0A096NB29_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled bile acid receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Membrane-type receptor for bile acids</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPBAR1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003907996.2">
        <property type="nucleotide sequence ID" value="XM_003907947.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017802466.1">
        <property type="nucleotide sequence ID" value="XM_017946977.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NB29"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009936"/>
    <dbReference type="Ensembl" id="ENSPANT00000018190.3">
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            <begin position="133"/>
            <end position="382"/>
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            <begin position="404"/>
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            <begin position="419"/>
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    <sequence length="432" mass="46044" checksum="CBD7BC97FF448998" modified="2022-05-25" version="2">MGWGSEDPQAPNTRHCRHHTRKCGGSLVYCQLTGQSRGLNVNASAEAGSQEGQDTRHGPNPCRAGCSNSLTLRKAQAGQAIPAPNSHACQLPLQDSPVLRTEMTPNSTGEVPSPIPKGVLGLSLALASLIVTANLLLALGIAWDRHLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLLYLAPNFSFLSLLANLLLVHGERYIAVLRPLQPPGSTRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAALLSVRVLVTAHRQLQDIRRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLISLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLRGRASRDSPGPSTAYHPSSQSSVDLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NC03</accession>
    <name>A0A096NC03_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DEPDC1B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003899703.5"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="RhoGAP_BRCC3-like"/>
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        <property type="entry name" value="DEP domain-containing protein 1B isoform X2"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="DEP_dom"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="108"/>
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            <begin position="201"/>
            <end position="393"/>
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            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="529" mass="61896" checksum="7770F8A8C924023B" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCA7</accession>
    <name>A0A096NCA7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.312</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Extracellular O-linked N-acetylglucosamine transferase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyltransferase-like domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">POMGNT2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37663"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:13618"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="ChEBI" id="CHEBI:137540"/>
            <dbReference type="EC" id="2.4.1.312"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 61 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.312" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003894639.1">
        <property type="nucleotide sequence ID" value="XM_003894590.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009199322.1">
        <property type="nucleotide sequence ID" value="XM_009201058.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017811019.1">
        <property type="nucleotide sequence ID" value="XM_017955530.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017811021.1">
        <property type="nucleotide sequence ID" value="XM_017955532.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519293.1">
        <property type="nucleotide sequence ID" value="XM_031663433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NCA7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000035139"/>
    <dbReference type="Ensembl" id="ENSPANT00000006410.3">
        <property type="protein sequence ID" value="ENSPANP00000010448.3"/>
        <property type="gene ID" value="ENSPANG00000007801.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000326"/>
    <dbReference type="KEGG" id="panu:101000326"/>
    <dbReference type="CTD" id="84892"/>
    <dbReference type="eggNOG" id="KOG4698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160695"/>
    <dbReference type="HOGENOM" id="CLU_020169_0_0_1"/>
    <dbReference type="OMA" id="EFQMRVV"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007801">
        <property type="expression patterns" value="Expressed in cerebellum and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035260082" description="Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2" evidence="18">
        <location>
            <begin position="17"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="488"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010448.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="580" mass="66500" checksum="9CD6FFA3095CDF4C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDG8</accession>
    <name>A0A096NDG8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein-lysine methyltransferase METTL21C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Methyltransferase-like protein 21C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">METTL21C</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Protein-lysine N-methyltransferase using S-adenosyl-L-methionine as methyl donor. Mono-di and trimethylates 'Lys-943' of AARS1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51737"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54200"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="Rhea" id="RHEA-COMP:13827"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54196"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="Rhea" id="RHEA-COMP:13827"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54197"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methyltransferase superfamily. METTL21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NDG8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010914"/>
    <dbReference type="Ensembl" id="ENSPANT00000006155.3">
        <property type="protein sequence ID" value="ENSPANP00000010914.2"/>
        <property type="gene ID" value="ENSPANG00000004347.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156596"/>
    <dbReference type="HOGENOM" id="CLU_055721_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004347">
        <property type="expression patterns" value="Expressed in gastrocnemius and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000188">
        <property type="entry name" value="Protein-lysine methyltransferase METTL21C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF13">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE METTL21C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010914.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="264" mass="29552" checksum="FE2D543CB1AE3800" modified="2022-05-25" version="2">MDVCLSSAQQPGRRGEGLSSPGGWLEAEKKGASQKDSTGGALEESDRIEPSLHSLQKFVPTDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGATALCQYLEKHAEELNFQDAKILEIGAGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKNTLRCTAHLPEVKELVWGEDLDKNFPKSAFYYDYVLASDVVYHHYFLDKLLTTMVYLSQPGTVLLWANKFRFSTDYEFLDKFKQVFDTTLLAEYPESSVKLFKGILKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDR0</accession>
    <name>A0A096NDR0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERGIC1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900575.1">
        <property type="nucleotide sequence ID" value="XM_003900526.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDR0"/>
    <dbReference type="Ensembl" id="ENSPANT00000006371.3">
        <property type="protein sequence ID" value="ENSPANP00000011007.3"/>
        <property type="gene ID" value="ENSPANG00000023223.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999211"/>
    <dbReference type="KEGG" id="panu:100999211"/>
    <dbReference type="CTD" id="57222"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063113"/>
    <dbReference type="HOGENOM" id="CLU_034705_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023223">
        <property type="expression patterns" value="Expressed in adrenal medulla and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDR0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF36">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="10">
        <location>
            <begin position="109"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011007.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="290" mass="32578" checksum="4983C7B8AB68E88D" modified="2022-05-25" version="3">MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHVIHKLSFGDTLQVQNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHJ8</accession>
    <name>A0A096NHJ8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ITPR3</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 21">Endoplasmic reticulum membrane</location>
            <topology evidence="1 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="21">Composed of a large N-terminal cytoplasmic domain (CD) followed by a juxtamembrane domain (JD) and a transmembrane domain (TMD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897510.4">
        <property type="nucleotide sequence ID" value="XM_003897461.5"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000026212.3">
        <property type="protein sequence ID" value="ENSPANP00000012446.3"/>
        <property type="gene ID" value="ENSPANG00000017411.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101001272"/>
    <dbReference type="KEGG" id="panu:101001272"/>
    <dbReference type="CTD" id="3710"/>
    <dbReference type="eggNOG" id="KOG3533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157078"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017411">
        <property type="expression patterns" value="Expressed in cornea and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NHJ8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031095">
        <property type="term" value="C:platelet dense tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23289">
        <property type="entry name" value="beta-trefoil_MIR_ITPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000002">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000028">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000001">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor, type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816:SF1">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816">
        <property type="entry name" value="MIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 21" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="6 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 21" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2201"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2238"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2268"/>
            <end position="2288"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIQ4</accession>
    <name>A0A096NIQ4_PAPAN</name>
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        <submittedName>
            <fullName evidence="9">Ring finger and SPRY domain containing 1</fullName>
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        <name evidence="9" type="primary">RSPRY1</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096NLF4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013812"/>
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        <property type="protein sequence ID" value="ENSPANP00000013812.3"/>
        <property type="gene ID" value="ENSPANG00000019371.3"/>
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    <dbReference type="HOGENOM" id="CLU_283220_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
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    <dbReference type="Bgee" id="ENSPANG00000019371">
        <property type="expression patterns" value="Expressed in testis and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032013">
        <property type="entry name" value="DUF4795"/>
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    <dbReference type="PANTHER" id="PTHR47080">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 96"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47080:SF1">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 96"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16043">
        <property type="entry name" value="DUF4795"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="765"/>
            <end position="942"/>
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        <location>
            <begin position="292"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="558"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="208"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="733"/>
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            <begin position="293"/>
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        <location>
            <begin position="318"/>
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    </feature>
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        <location>
            <begin position="328"/>
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    </feature>
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        <location>
            <begin position="339"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="350"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="418"/>
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    </feature>
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            <begin position="470"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1126"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF16043"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013812.3"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMF2</accession>
    <accession>A0A2I3M234</accession>
    <name>A0A096NMF2_PAPAN</name>
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        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4</fullName>
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            <fullName evidence="7">60S ribosomal protein L4</fullName>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="5">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the large ribosomal subunit. May bind IPO9 with low affinity. Interacts with RBM3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003901089.5"/>
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        <property type="protein sequence ID" value="ENSPANP00000029770.2"/>
        <property type="gene ID" value="ENSPANG00000012606.3"/>
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    <dbReference type="Ensembl" id="ENSPANT00000026462.3">
        <property type="protein sequence ID" value="ENSPANP00000014161.2"/>
        <property type="gene ID" value="ENSPANG00000016666.3"/>
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    <dbReference type="GeneID" id="101008751"/>
    <dbReference type="KEGG" id="panu:101008751"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 14"/>
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        <property type="expression patterns" value="Expressed in mesenteric lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribos_uL4_C_dom"/>
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        <property type="entry name" value="Ribosomal_uL4"/>
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        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
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        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
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        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="10">
        <location>
            <begin position="275"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014161.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="427" mass="47698" checksum="479830F174411792" modified="2022-05-25" version="2">MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAALEAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTTEEKKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNX5</accession>
    <name>A0A096NNX5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SERF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NNX5"/>
    <dbReference type="SMR" id="A0A096NNX5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014685"/>
    <dbReference type="Ensembl" id="ENSPANT00000003717.3">
        <property type="protein sequence ID" value="ENSPANP00000014685.2"/>
        <property type="gene ID" value="ENSPANG00000018110.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144347"/>
    <dbReference type="HOGENOM" id="CLU_125535_0_0_1"/>
    <dbReference type="OMA" id="LPLGHTW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018110">
        <property type="expression patterns" value="Expressed in supraoptic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NNX5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040211">
        <property type="entry name" value="SERF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596">
        <property type="entry name" value="SMALL EDRK-RICH FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596:SF2">
        <property type="entry name" value="SMALL EDRK-RICH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014685.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="170" mass="18315" checksum="6EDA45B82A43FFBD" modified="2018-02-28" version="2">MTRGNQRELARQKNMKKQSDSVKGKRRDDGLSAAARKQRVGVQQPNAELSPIHFHLILCALHPPASCPFCPLVPPSAPSSLPPGTRRSCSRSRKRQTRRRRNPSSFVASCPTLLPFACVPGASPTTLAFPPVVLTGPSTDGIPFALSLQRVPFVLPSPQVASLPLGHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPE8</accession>
    <name>A0A096NPE8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">OSBPL3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with RRAS. Interacts (phosphorylated form) with VAPA. Interacts with OSBPL6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896233.3">
        <property type="nucleotide sequence ID" value="XM_003896184.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009201477.3">
        <property type="nucleotide sequence ID" value="XM_009203213.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017812335.3">
        <property type="nucleotide sequence ID" value="XM_017956846.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017812336.3">
        <property type="nucleotide sequence ID" value="XM_017956847.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NPE8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000041666"/>
    <dbReference type="Ensembl" id="ENSPANT00000018679.3">
        <property type="protein sequence ID" value="ENSPANP00000014877.3"/>
        <property type="gene ID" value="ENSPANG00000019047.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999284"/>
    <dbReference type="KEGG" id="panu:100999284"/>
    <dbReference type="CTD" id="26031"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155957"/>
    <dbReference type="HOGENOM" id="CLU_007105_4_1_1"/>
    <dbReference type="OMA" id="XAKYWST"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019047">
        <property type="expression patterns" value="Expressed in urinary bladder and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NPE8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006699">
        <property type="term" value="P:bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13287">
        <property type="entry name" value="PH_ORP3_ORP6_ORP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000011">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000004">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF15">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 20" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014877.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="887" mass="101048" checksum="7468E7CCBD3DC400" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQI8</accession>
    <name>A0A096NQI8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Upstream transcription factor family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">USF3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017810637.2">
        <property type="nucleotide sequence ID" value="XM_017955148.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810638.2">
        <property type="nucleotide sequence ID" value="XM_017955149.3"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000015292"/>
    <dbReference type="Ensembl" id="ENSPANT00000020821.3">
        <property type="protein sequence ID" value="ENSPANP00000015292.3"/>
        <property type="gene ID" value="ENSPANG00000019193.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006016"/>
    <dbReference type="KEGG" id="panu:101006016"/>
    <dbReference type="CTD" id="205717"/>
    <dbReference type="eggNOG" id="ENOG502QVK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015759"/>
    <dbReference type="HOGENOM" id="CLU_001249_0_0_1"/>
    <dbReference type="OMA" id="CVPDQEV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019193">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQI8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18910">
        <property type="entry name" value="bHLHzip_USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000051">
        <property type="entry name" value="Basic helix-loop-helix domain-containing protein KIAA2018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053252">
        <property type="entry name" value="EMT_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048064">
        <property type="entry name" value="USF3_bHLH"/>
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    <dbReference type="PANTHER" id="PTHR46970">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46970:SF1">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="471"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="932"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1041"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1082"/>
            <end position="1102"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1162"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1208"/>
            <end position="1239"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1307"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1421"/>
            <end position="1441"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1630"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1648"/>
            <end position="1670"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1742"/>
            <end position="1770"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1840"/>
            <end position="1884"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1897"/>
            <end position="2037"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="2223"/>
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            <begin position="82"/>
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            <begin position="273"/>
            <end position="288"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="447"/>
            <end position="469"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="900"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="1102"/>
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            <begin position="1185"/>
            <end position="1196"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1219"/>
            <end position="1239"/>
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            <begin position="1319"/>
            <end position="1331"/>
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            <begin position="1429"/>
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            <end position="1526"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1534"/>
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            <begin position="1576"/>
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            <begin position="1599"/>
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            <begin position="1648"/>
            <end position="1660"/>
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            <begin position="1910"/>
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        <location>
            <begin position="2004"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2223"/>
            <end position="2232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015292.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2251" mass="242471" checksum="ED71EACEBACA0A7B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQP0</accession>
    <name>A0A096NQP0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPN2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009200976.1">
        <property type="nucleotide sequence ID" value="XM_009202712.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A096NQP0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015352"/>
    <dbReference type="Ensembl" id="ENSPANT00000019709.3">
        <property type="protein sequence ID" value="ENSPANP00000015352.1"/>
        <property type="gene ID" value="ENSPANG00000005722.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022258"/>
    <dbReference type="KEGG" id="panu:101022258"/>
    <dbReference type="CTD" id="54707"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183172"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005722">
        <property type="expression patterns" value="Expressed in ascending colon and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQP0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
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        <property type="entry name" value="Gpn2"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_bind_1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046611"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
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            <dbReference type="Ensembl" id="ENSPANP00000015352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="310" mass="34462" checksum="F7241F808DA683CA" modified="2014-11-26" version="1">MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELVGLGDVMDALRLGPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTHHGALRSIFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHINLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAVDKANGYCFGAQEQRSLEAMMSAAMGADFHFSSTLGIQEKYLAPSNQSVEQEAMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQW8</accession>
    <name>A0A096NQW8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T cell receptor gamma variable 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRGV9</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Gamma-delta TR is a heterodimer composed of a gamma and delta chain; disulfide-linked. The gamma-delta TR is associated with the transmembrane signaling CD3 coreceptor proteins following the stoichiometry: a single gamma-delta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. Upon activation, gamma-delta TR complex associates with FCER1G to initiate intracellular signaling.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQW8"/>
    <dbReference type="Ensembl" id="ENSPANT00000021547.3">
        <property type="protein sequence ID" value="ENSPANP00000015432.2"/>
        <property type="gene ID" value="ENSPANG00000001237.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SQHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153143"/>
    <dbReference type="HOGENOM" id="CLU_077975_7_0_1"/>
    <dbReference type="OMA" id="YYCAFWE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001237">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:adaptive immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="T cell receptor gamma variable 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051117">
        <property type="entry name" value="TRG_var/const_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19256:SF44">
        <property type="entry name" value="T CELL RECEPTOR GAMMA VARIABLE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19256">
        <property type="entry name" value="T-CELL RECEPTOR GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015432.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="117" mass="13257" checksum="79BC0621735E3CC0" modified="2018-02-28" version="2">AGHLEQPQISSTKMLSKTARLECVVSGVTISETSIYWYRERPGEVIQFLVCIFYDGTVKKESSIPSGKFEVDRIPKTSTSTLTIHNVEKQDIATYYCALWDVHSSRQLEPSHSINVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRK8</accession>
    <name>A0A096NRK8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TAL bHLH transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TAL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_009188365.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021782994.1">
        <property type="nucleotide sequence ID" value="XM_021927302.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NRK8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015678"/>
    <dbReference type="Ensembl" id="ENSPANT00000021128.3">
        <property type="protein sequence ID" value="ENSPANP00000015678.1"/>
        <property type="gene ID" value="ENSPANG00000017357.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023827"/>
    <dbReference type="KEGG" id="panu:101023827"/>
    <dbReference type="CTD" id="6887"/>
    <dbReference type="eggNOG" id="KOG4029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160867"/>
    <dbReference type="HOGENOM" id="CLU_158724_0_0_1"/>
    <dbReference type="OMA" id="EDCGVPS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017357">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021794">
        <property type="term" value="P:thalamus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19707">
        <property type="entry name" value="bHLH_TS_TAL2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="T-cell acute lymphocytic leukemia 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF21">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0160">Chromosomal rearrangement</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015678.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="108" mass="12301" checksum="DF8862D940EF4752" modified="2014-11-26" version="1">MTRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMRYINFLVKVLGEQSLQQTGVPAQGNILGLFPQGPHLPGLEDRTPLENYQVPSPGPSHHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSX9</accession>
    <name>A0A096NSX9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OCA2 melanosomal transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OCA2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003900728.2">
        <property type="nucleotide sequence ID" value="XM_003900679.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A096NSX9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000032262"/>
    <dbReference type="Ensembl" id="ENSPANT00000028202.3">
        <property type="protein sequence ID" value="ENSPANP00000016150.2"/>
        <property type="gene ID" value="ENSPANG00000020154.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022567"/>
    <dbReference type="KEGG" id="panu:101022567"/>
    <dbReference type="CTD" id="4948"/>
    <dbReference type="eggNOG" id="KOG2639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234550"/>
    <dbReference type="HOGENOM" id="CLU_011920_2_1_1"/>
    <dbReference type="OMA" id="HHRIRDK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020154">
        <property type="expression patterns" value="Expressed in iris and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NSX9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035752">
        <property type="term" value="P:lysosomal lumen pH elevation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006583">
        <property type="term" value="P:melanin biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
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    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="370"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="531"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="644"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="667"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="701"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="721"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="812"/>
            <end position="835"/>
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    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="342"/>
            <end position="775"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016150.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="838" mass="92607" checksum="31893F098403F294" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NV16</accession>
    <name>A0A096NV16_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-defensin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DEFB118</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has antibacterial activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta-defensin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904959.1">
        <property type="nucleotide sequence ID" value="XM_003904910.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NV16"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016891"/>
    <dbReference type="Ensembl" id="ENSPANT00000013703.3">
        <property type="protein sequence ID" value="ENSPANP00000016891.1"/>
        <property type="gene ID" value="ENSPANG00000023986.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024128"/>
    <dbReference type="KEGG" id="panu:101024128"/>
    <dbReference type="CTD" id="117285"/>
    <dbReference type="eggNOG" id="ENOG502TM86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064565"/>
    <dbReference type="HOGENOM" id="CLU_164142_0_0_1"/>
    <dbReference type="OMA" id="CWNKSGH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023986">
        <property type="expression patterns" value="Expressed in thyroid gland"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140912">
        <property type="term" value="F:membrane destabilizing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031665">
        <property type="term" value="P:negative regulation of lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050544">
        <property type="entry name" value="Beta-defensin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025933">
        <property type="entry name" value="Beta_defensin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15001">
        <property type="entry name" value="BETA-DEFENSIN 123-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15001:SF7">
        <property type="entry name" value="DEFENSIN BETA 118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13841">
        <property type="entry name" value="Defensin_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4 9" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6 9" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005107985" description="Beta-defensin" evidence="9">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-defensin" evidence="11">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU231113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="123" mass="13708" checksum="FF5AF37300F797B7" modified="2014-11-26" version="1">MKLLLLALPILVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKETCKNLRACCVPSNEDHRRLPTTSPTPLSDSTPGIIDNILTIRFTTDYFEISSKKDMVEESEAEQGTQTSPPNVHHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWF8</accession>
    <name>A0A096NWF8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">StAR-related lipid transfer protein 7, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">START domain-containing protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">STARD7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a protective role in mucosal tissues by preventing exaggerated allergic responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003909022.1">
        <property type="nucleotide sequence ID" value="XM_003908973.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWF8"/>
    <dbReference type="SMR" id="A0A096NWF8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017385"/>
    <dbReference type="Ensembl" id="ENSPANT00000020465.3">
        <property type="protein sequence ID" value="ENSPANP00000017385.1"/>
        <property type="gene ID" value="ENSPANG00000000472.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101026736"/>
    <dbReference type="KEGG" id="panu:101026736"/>
    <dbReference type="CTD" id="56910"/>
    <dbReference type="eggNOG" id="KOG2761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157856"/>
    <dbReference type="HOGENOM" id="CLU_042209_0_0_1"/>
    <dbReference type="OMA" id="NQLCERC"/>
    <dbReference type="OrthoDB" id="1295045at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000472">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140104">
        <property type="term" value="F:molecular carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120197">
        <property type="term" value="P:mucociliary clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001773">
        <property type="term" value="P:myeloid dendritic cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042092">
        <property type="term" value="P:type 2 immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08911">
        <property type="entry name" value="START_STARD7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000016">
        <property type="entry name" value="StAR-related lipid transfer protein 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041949">
        <property type="entry name" value="START_STARD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="START" evidence="9">
        <location>
            <begin position="137"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="370" mass="43133" checksum="9E389D422D22CD2A" modified="2014-11-26" version="1">MFPRRLLAAWLAGARGGGLLALLANQCRFVTGLRVRRAQQIAQLYGRLYSERSRRVLLGRLWRRLHGRPGHASALMAAFAGVFVWDEERIQEEELQRSINEMKRLEEMSNMFQSSGVQHHPPEPKAQTEGNEDSEGKEQPWEMVMDKKHFKLWRRPITGTHLYQYRVFGTYTDVTPRQFFNVQLDTEYRKKWDALVIKLEVIERDVVSGSEVLHWVTHFPYPMYSRDYVYVRRYSVDQENNMMVLVSRAVEHPSVPESPEFVRVRSYESQMVIRPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKAKNMEIKVKDYISAKPLEMSSEAKATSQSSERKNEGSCGPAQIEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWZ4</accession>
    <name>A0A096NWZ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Synaptojanin-2</fullName>
            <ecNumber evidence="7">3.1.3.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">SYNJ2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="7"/>
    <dbReference type="RefSeq" id="XP_009204063.1">
        <property type="nucleotide sequence ID" value="XM_009205799.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204064.1">
        <property type="nucleotide sequence ID" value="XM_009205800.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000026355.3">
        <property type="protein sequence ID" value="ENSPANP00000017584.1"/>
        <property type="gene ID" value="ENSPANG00000010755.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101024196"/>
    <dbReference type="CTD" id="8871"/>
    <dbReference type="GeneTree" id="ENSGT00940000160715"/>
    <dbReference type="HOGENOM" id="CLU_003016_5_2_1"/>
    <dbReference type="OMA" id="PCRYKDD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010755">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWZ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12720">
        <property type="entry name" value="RRM_SYNJ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000204">
        <property type="entry name" value="Synaptojanin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000008">
        <property type="entry name" value="Synaptojanin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015047">
        <property type="entry name" value="SYNJ1/2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034973">
        <property type="entry name" value="SYNJ2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF148">
        <property type="entry name" value="SYNAPTOJANIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08952">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01165">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 22" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="SAC" evidence="25">
        <location>
            <begin position="120"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="24">
        <location>
            <begin position="889"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1028"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1085"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1191"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1049"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1101"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1221"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143140" checksum="018E1CDE68484242" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXI7</accession>
    <name>A0A096NXI7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ESPL1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031506361.1">
        <property type="nucleotide sequence ID" value="XM_031650501.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506362.1">
        <property type="nucleotide sequence ID" value="XM_031650502.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000017782"/>
    <dbReference type="Ensembl" id="ENSPANT00000004381.3">
        <property type="protein sequence ID" value="ENSPANP00000017782.3"/>
        <property type="gene ID" value="ENSPANG00000022963.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019541"/>
    <dbReference type="CTD" id="9700"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004990"/>
    <dbReference type="HOGENOM" id="CLU_001558_0_0_1"/>
    <dbReference type="OMA" id="YMGMTAS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022963">
        <property type="expression patterns" value="Expressed in bone marrow and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000212">
        <property type="term" value="P:meiotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1945"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1303"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1508"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1540"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1311"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1464"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1540"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017782.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2120" mass="233022" checksum="49C8E4F2F7D95585" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P026</accession>
    <name>A0A096P026_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">OSBPL10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with OSBPL9. Interacts with DIAPH1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017811495.3">
        <property type="nucleotide sequence ID" value="XM_017956006.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P026"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018701"/>
    <dbReference type="Ensembl" id="ENSPANT00000014150.3">
        <property type="protein sequence ID" value="ENSPANP00000018701.3"/>
        <property type="gene ID" value="ENSPANG00000011538.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024744"/>
    <dbReference type="KEGG" id="panu:101024744"/>
    <dbReference type="CTD" id="114884"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157880"/>
    <dbReference type="HOGENOM" id="CLU_012334_3_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011538">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P026">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13291">
        <property type="entry name" value="PH_ORP10_ORP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000278">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF47">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018701.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="764" mass="83899" checksum="339053AF6BB1AC33" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P083</accession>
    <name>A0A096P083_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Ribokinase</fullName>
            <shortName evidence="14">RK</shortName>
            <ecNumber evidence="2 14">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RBKS</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_003908493.1">
        <property type="nucleotide sequence ID" value="XM_003908444.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A096P083"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018758"/>
    <dbReference type="Ensembl" id="ENSPANT00000019917.3">
        <property type="protein sequence ID" value="ENSPANP00000018758.1"/>
        <property type="gene ID" value="ENSPANG00000007399.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011016"/>
    <dbReference type="KEGG" id="panu:101011016"/>
    <dbReference type="CTD" id="64080"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005743"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_3_1"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007399">
        <property type="expression patterns" value="Expressed in metanephros cortex and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000022">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 14" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="16">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="322" mass="34279" checksum="3F86B006036562E4" modified="2014-11-26" version="1">MAASGEPWRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGATTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMAHRSGVKTLFNPAPAIADLDPRFYTLSDVFCCNESEAEILTGLTVNSAADAGEAALVLLRRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLKRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0S9</accession>
    <name>A0A096P0S9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Orosomucoid 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ORM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P0S9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018954"/>
    <dbReference type="Ensembl" id="ENSPANT00000027609.3">
        <property type="protein sequence ID" value="ENSPANP00000018954.3"/>
        <property type="gene ID" value="ENSPANG00000025785.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S0Q2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012130"/>
    <dbReference type="HOGENOM" id="CLU_117688_0_0_1"/>
    <dbReference type="OMA" id="KTFMLAF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025785">
        <property type="expression patterns" value="Expressed in liver and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031093">
        <property type="term" value="C:platelet alpha granule lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035580">
        <property type="term" value="C:specific granule lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032731">
        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19451">
        <property type="entry name" value="lipocalin_AGP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000012">
        <property type="entry name" value="Alpha-1-acid glycoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001500">
        <property type="entry name" value="A1A_glycop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11967">
        <property type="entry name" value="ALPHA-1-ACID GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11967:SF2">
        <property type="entry name" value="ALPHA-1-ACID GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00708">
        <property type="entry name" value="A1AGLPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0011">Acute phase</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="10">
        <location>
            <begin position="76"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018954.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="250" mass="29413" checksum="9724E1487E734606" modified="2022-05-25" version="3">MNQTLAMVTTYDGQQPRIETVKKRRARKGEACRQIPVPDWDMALVLSLLPLLEAQIPLCANLVPVPITNATLDWISGKWFYIASAFRNEEYNKSTHEIQATFFYFTPNKTEDTIFLREYQTRQNQCIYNTSYLNVQRENGTISRYVGGQEHFAHLLILRDRKTFMLAFEVNDEKNWGVSVYADKPETTEEQLGEFYEALDCLRIPRSDVMYTNQKKDKCEPLERQHEKEKKQEEGERQHEKEKKQEEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0Z1</accession>
    <name>A0A096P0Z1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FSD1L</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_017805159.1">
        <property type="nucleotide sequence ID" value="XM_017949670.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P0Z1"/>
    <dbReference type="Ensembl" id="ENSPANT00000027271.3">
        <property type="protein sequence ID" value="ENSPANP00000019016.2"/>
        <property type="gene ID" value="ENSPANG00000025726.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025102"/>
    <dbReference type="CTD" id="83856"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157979"/>
    <dbReference type="HOGENOM" id="CLU_013137_19_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025726">
        <property type="expression patterns" value="Expressed in gastrocnemius and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P0Z1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12901">
        <property type="entry name" value="SPRY_PRY_FSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035742">
        <property type="entry name" value="SPRY/PRY_FSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF8">
        <property type="entry name" value="FSD1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="COS" evidence="11">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="298"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019016.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="509" mass="57210" checksum="9FF67C95AA93165A" modified="2018-02-28" version="2">MDSQKEALQRIISTLANKNDEIQNFIDTLNHTLKGVQENSSNILSELDEEFDSLYSILDEVKESMINCIKQEQARKSQELQSQISQCNNALENSEELLEFATRSLDIKEPEEFSKAARQIKDRVTMASAFRLSLKPKVSDNMTHLMVDFSQERQMLQTLKFLPVPKAPEIDPVECLVADNSVTVAWRMLEEDNKIDHFILEHRKTNYDGLPRVKDERCWEIIDNIKGTEYTLSGLKFDSKYMNFRVRACNKAVAGEYSDPVTLETKALNFNLDNSSSHLNLKVEDTCVEWDPTGGKGQESKMKGKENKGSVHVTSLKKHTRSGTPSPKRTSVGSRPPAVRGSRDRFTGESYTVLGDTAIESGQHYWEVKAQKDCKSYSVGVAYKTLGKFDQLGKTNTSWCIHVNNWLQNTFAAKHNNKVKALDVTVPEKIGVFCDFDGGQLSFYDANSKQLLYSFKTKFTQPVLPGFMVWCGGLSLSTGMQVPSAVRTLQKSENGMTGSASSLNNVVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P238</accession>
    <name>A0A096P238_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Asporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ASPN</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009187459.3">
        <property type="nucleotide sequence ID" value="XM_009189195.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P238"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019413"/>
    <dbReference type="Ensembl" id="ENSPANT00000024547.3">
        <property type="protein sequence ID" value="ENSPANP00000019413.2"/>
        <property type="gene ID" value="ENSPANG00000024729.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007633"/>
    <dbReference type="KEGG" id="panu:101007633"/>
    <dbReference type="CTD" id="54829"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157444"/>
    <dbReference type="HOGENOM" id="CLU_000288_186_0_1"/>
    <dbReference type="OMA" id="INDFCPT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024729">
        <property type="expression patterns" value="Expressed in aorta and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P238">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070171">
        <property type="term" value="P:negative regulation of tooth mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000038">
        <property type="entry name" value="Biglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016352">
        <property type="entry name" value="SLRP_I_decor/aspor/byglycan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF2">
        <property type="entry name" value="ASPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002490">
        <property type="entry name" value="SLRP_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014196749" description="Asporin" evidence="12">
        <location>
            <begin position="16"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="69"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002490-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019413.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="374" mass="42773" checksum="3B8D7D6DBF810887" modified="2018-02-28" version="2">MKEYVLLLFLGLCSAKPFFSPSHMALKNMMLKDMEDTDDDDEEEEEENSLFPTREPRIPFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5I6</accession>
    <name>A0A096P5I6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">B-TFIID TATA-box binding protein associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BTAF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
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                <person name="Morales K.M."/>
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                <person name="Nguyen N.N."/>
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                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
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                <person name="Usmani K.U."/>
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                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <property type="entry name" value="DUF4732"/>
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        <property type="entry name" value="CHROMOSOME 19 C19ORF81 HOMOLOG"/>
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    <dbReference type="PANTHER" id="PTHR37153:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC292874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15876">
        <property type="entry name" value="DUF4732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="198" mass="22449" checksum="64205BC6220E9E97" modified="2015-01-07" version="1">MQPEVEPMCSSTIGSLTMHREAGALLMDLETPEEMQARSLSRPIKSSKQYLRQVIAEYEALDRELPCIRKFPTPPAAQPLCLCMETLPEEDFTHLEVLQALEAQLPGAMESGRVSSIRFENMNVICGTAGRRNRWLIAVTDFQTRSRLLRSGLSPRGLAHQLVRHDDLLLGDYRLHLRRSLVRRRMLEALGAEPNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUI5</accession>
    <name>A0A0A0MUI5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUI5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001624"/>
    <dbReference type="Ensembl" id="ENSPANT00000028531.3">
        <property type="protein sequence ID" value="ENSPANP00000001624.3"/>
        <property type="gene ID" value="ENSPANG00000019472.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S41V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="HOGENOM" id="CLU_024444_6_2_1"/>
    <dbReference type="OMA" id="CEAMNIH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019472">
        <property type="expression patterns" value="Expressed in bone marrow and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101003">
        <property type="term" value="C:ficolin-1-rich granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070821">
        <property type="term" value="C:tertiary granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05712">
        <property type="entry name" value="IgV_CD33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002151">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000829">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035232977" description="Ig-like domain-containing protein" evidence="14">
        <location>
            <begin position="17"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="242"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001624.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="535" mass="58839" checksum="91233879F023AC1D" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUV1</accession>
    <name>A0A0A0MUV1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane and immunoglobulin domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMIGD2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUV1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003687"/>
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        <property type="protein sequence ID" value="ENSPANP00000003687.3"/>
        <property type="gene ID" value="ENSPANG00000019801.3"/>
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    <dbReference type="eggNOG" id="ENOG502SX6X">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000007100"/>
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        <property type="component" value="Chromosome 20"/>
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        <property type="expression patterns" value="Expressed in thymus and 22 other cell types or tissues"/>
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        <property type="term" value="C:B cell receptor complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:coreceptor activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
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    <dbReference type="GO" id="GO:0050853">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042104">
        <property type="term" value="P:positive regulation of activated T cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transmembrane and immunoglobulin domain containing 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035232972" evidence="4">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003687.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="274" mass="29543" checksum="226AE5E5A99D5241" modified="2022-05-25" version="3">MGSPGMVLGLLVQFWALQGASSLSVQQGPNLQVRQGSQATLVCQVDQAPAWERLRVRWTKDGAILCQPYITNSSLSLGVCGPQGQLSWQAPSHLILKLDPVSLNHSGAYVCSAAIEIPELEEAEGNVTRLLVDPDDPTQNRNPTPSFLGLLFVLLGAGSVGVAIMLGAWFRGHRCCQQRDSGNSPGNAFYSNVLYRPRGAPKKTEDCSGEAKDQRGQSIYSTSFPQPVTCQPHLAPRPCPSPRPGHPISMVRVFPSPGPTQQPRPRGFPKVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVI3</accession>
    <name>A0A0A0MVI3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">TIR domain-containing adapter molecule 1</fullName>
            <shortName evidence="15">TICAM-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TICAM1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The N-terminal region is essential for activation of the IFNB promoter activity.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003919632.3">
        <property type="nucleotide sequence ID" value="XM_003919583.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVI3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006835"/>
    <dbReference type="Ensembl" id="ENSPANT00000013353.3">
        <property type="protein sequence ID" value="ENSPANP00000006835.3"/>
        <property type="gene ID" value="ENSPANG00000009133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015106"/>
    <dbReference type="KEGG" id="panu:101015106"/>
    <dbReference type="CTD" id="148022"/>
    <dbReference type="eggNOG" id="ENOG502RXF3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162411"/>
    <dbReference type="HOGENOM" id="CLU_022539_0_0_1"/>
    <dbReference type="OMA" id="TRHGWQD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009133">
        <property type="expression patterns" value="Expressed in cornea and 39 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097342">
        <property type="term" value="C:ripoptosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140052">
        <property type="term" value="P:cellular response to oxidised low-density lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:inflammatory response"/>
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    <keyword evidence="5 15" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="394"/>
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            <begin position="347"/>
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    <sequence length="713" mass="76846" checksum="2189D4B925FF3AFA" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVJ6</accession>
    <name>A0A0A0MVJ6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kallikrein-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Enamel matrix serine proteinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Kallikrein-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Serine protease 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">KLK4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003916026.1">
        <property type="nucleotide sequence ID" value="XM_003915977.5"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000006963"/>
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        <property type="protein sequence ID" value="ENSPANP00000006963.1"/>
        <property type="gene ID" value="ENSPANG00000014278.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006869"/>
    <dbReference type="KEGG" id="panu:101006869"/>
    <dbReference type="CTD" id="9622"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230389"/>
    <dbReference type="HOGENOM" id="CLU_006842_1_1_1"/>
    <dbReference type="OMA" id="CKFTNWI"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014278">
        <property type="expression patterns" value="Expressed in prostate gland and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097186">
        <property type="term" value="P:amelogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000091">
        <property type="entry name" value="Kallikrein-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000100">
        <property type="entry name" value="Kallikrein-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF65">
        <property type="entry name" value="KALLIKREIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 18" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001967198" description="Kallikrein-4" evidence="19">
        <location>
            <begin position="27"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="20">
        <location>
            <begin position="31"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="254" mass="27261" checksum="1DD1577D7CCDD26C" modified="2015-01-07" version="1">MTTAGSPWGWLLGYLILGATGSLVSGSSSRIINGEDCIPHSQPWQAALIMENELFCSGVLVHPQWVLSAAHCFQKSYTIGLGLHSLEADQEPGSRMVEASYSVQHPEYNRPLLANDLMLIKLDESVSESATIRNISLASRCPTAGDSCLVSGWGLLANGRMPTVLQCVNLSVVSEEVCSELYDPLYHPSMFCAGGGQDRKDSCYGDSGGPLICNGYLQGLVSFGQGQCGQVGVPSVYTNLCKFTEWIEKTVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWY0</accession>
    <name>A0A0A0MWY0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipase A2 inhibitor and LY6/PLAUR domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PINLYP</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNF-like-inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWY0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010645"/>
    <dbReference type="Ensembl" id="ENSPANT00000000423.3">
        <property type="protein sequence ID" value="ENSPANP00000010645.2"/>
        <property type="gene ID" value="ENSPANG00000020938.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SRI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111229"/>
    <dbReference type="HOGENOM" id="CLU_094248_0_0_1"/>
    <dbReference type="OMA" id="ESACYAK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020938">
        <property type="expression patterns" value="Expressed in cornea and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23571">
        <property type="entry name" value="TFP_LU_ECD_PINLYP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23572">
        <property type="entry name" value="TFP_LU_ECD_PINLYP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050918">
        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004126">
        <property type="entry name" value="PLipase_A2_inh_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF25">
        <property type="entry name" value="PHOSPHOLIPASE A2 INHIBITOR AND LY6_PLAUR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02988">
        <property type="entry name" value="PLA2_inh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2 inhibitor N-terminal" evidence="7">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="6">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010645.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="229" mass="25173" checksum="587BFDE5F1D4E24D" modified="2018-02-28" version="2">MWVRTRPSSASYKSWRPGTADTHTMRPSRRQGTLLLAFVLLCTLLGLGCPLRCEICKAPGSRCHGQMRTCSSDKDTCVLLVGKATSKGKEWVHTYKGCMRSQDCYSGVVSTTMGPRDYMVTRSFCCQSDGCNSAFLSVPLTDRTENGLMCPACTATFRDKCMGPMTRCTGQENRCVSLSGHVQAGIFKPRFAMRGCATESMCFAKPGAELPTGTHVLFLHHTECTHSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGA1</accession>
    <name>A0A2I3LGA1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BRCA2 DNA repair associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BRCA2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
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                <person name="Carter K.C."/>
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                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
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                <person name="Garcia-Iii R.G."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
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                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000022490"/>
    <dbReference type="Ensembl" id="ENSPANT00000041411.2">
        <property type="protein sequence ID" value="ENSPANP00000022490.2"/>
        <property type="gene ID" value="ENSPANG00000013323.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003602"/>
    <dbReference type="OMA" id="CWYTKLG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013323">
        <property type="expression patterns" value="Expressed in bone marrow and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LGA1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033593">
        <property type="term" value="C:BRCA2-MAGE-D1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990391">
        <property type="term" value="C:DNA repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000152">
        <property type="term" value="C:nuclear ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protease binding"/>
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        <property type="term" value="F:single-stranded DNA binding"/>
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    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
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    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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    <dbReference type="GO" id="GO:0070200">
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    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1041"/>
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    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
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    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="1424"/>
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    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="1520"/>
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    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="1667"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="1840"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="1974"/>
            <end position="2008"/>
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    </feature>
    <feature type="repeat" description="BRCA2" evidence="13">
        <location>
            <begin position="2055"/>
            <end position="2089"/>
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    </feature>
    <feature type="domain" description="Tower" evidence="15">
        <location>
            <begin position="2835"/>
            <end position="2876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1726"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2433"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3394"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1729"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="3396"/>
            <end position="3412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022490.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="3420" mass="384381" checksum="274DD54D56D2BE56" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LMA8</accession>
    <name>A0A2I3LMA8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Recombining binding protein suppressor of hairless</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">J kappa-recombination signal-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RBP-J kappa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RBPJ</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LMA8"/>
    <dbReference type="Ensembl" id="ENSPANT00000031469.2">
        <property type="protein sequence ID" value="ENSPANP00000024569.2"/>
        <property type="gene ID" value="ENSPANG00000021176.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005197"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021176">
        <property type="expression patterns" value="Expressed in testis and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LMA8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007221">
        <property type="term" value="P:positive regulation of transcription of Notch receptor target"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01176">
        <property type="entry name" value="IPT_RBP-Jkappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000001">
        <property type="entry name" value="Recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000003">
        <property type="entry name" value="recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000074">
        <property type="entry name" value="Recombining binding protein suppressor of hairless, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="15">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="16">
        <location>
            <begin position="169"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024569.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="490" mass="54825" checksum="87A81355A0D2B5B4" modified="2022-05-25" version="2">MFSSLNNSFRKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGSYTNASTNSTSVTSSTATVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LMJ0</accession>
    <name>A0A2I3LMJ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protein NEDD8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Neddylin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with AHR; interaction is direct. Interacts with NUB1; interaction is direct. Interacts with ESR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031525020.1">
        <property type="nucleotide sequence ID" value="XM_031669160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LMJ0"/>
    <dbReference type="SMR" id="A0A2I3LMJ0"/>
    <dbReference type="Ensembl" id="ENSPANT00000045437.2">
        <property type="protein sequence ID" value="ENSPANP00000024649.2"/>
        <property type="gene ID" value="ENSPANG00000034048.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101026095"/>
    <dbReference type="KEGG" id="panu:101026095"/>
    <dbReference type="CTD" id="4738"/>
    <dbReference type="GeneTree" id="ENSGT00940000155856"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034048">
        <property type="expression patterns" value="Expressed in thymus and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024649.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="81" mass="9072" checksum="DC2FE102BE4725D2" modified="2022-05-25" version="2">MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LQP5</accession>
    <name>A0A2I3LQP5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="13">HIU hydrolase</shortName>
            <shortName evidence="13">HIUHase</shortName>
            <ecNumber evidence="6 13">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6 13"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3LQP5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000025806"/>
    <dbReference type="Ensembl" id="ENSPANT00000058206.2">
        <property type="protein sequence ID" value="ENSPANP00000025806.2"/>
        <property type="gene ID" value="ENSPANG00000030949.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153229"/>
    <dbReference type="OMA" id="CSENQNY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030949">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.180:FF:000004">
        <property type="entry name" value="5-hydroxyisourate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF11">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8 13" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025806.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="141" mass="16045" checksum="1F582A355C97542C" modified="2022-05-25" version="2">MSSRAAPRLLRLQRHLGPQEGSSMEPTDSPLTTHVLDTASGLPATGLCLRLSWLEDHSQQWMELRTSYTDPDGRCPGLLMPDQMKAGTYKLTFDTEGYWRKRGQESFYPYVEVVFTITSNAQKFHVPLLLSPWSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M0X9</accession>
    <name>A0A2I3M0X9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M0X9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000029383"/>
    <dbReference type="Ensembl" id="ENSPANT00000032493.2">
        <property type="protein sequence ID" value="ENSPANP00000029383.2"/>
        <property type="gene ID" value="ENSPANG00000032709.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222287"/>
    <dbReference type="OMA" id="LFGWGEV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000431">
        <property type="entry name" value="5HT5B_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00519">
        <property type="entry name" value="5HT5BRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="69"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029383.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="296" mass="32644" checksum="29696B18A900B9D9" modified="2022-05-25" version="2">MEAANLSVATTSVALALGPKTCSSSPSPSGILSSTPGNAVLPGREPPFSVFMVLVVTLLVLLIAATFLWNLLVLVTILWVRAFHRVPHNLVASTAVSDVLVAELVMPLSLVSELSTGRRWLLGRSLCHVWISFDVLCCTASIRNVAAIALDRYWTITRHLQYTLLTRRRASALMIALTWALSALIALTPLLFGWGEVYDARLQCCQVSQEPSYAVFSTCGAFYLPLGVVLFVYWKIYKAAKFRFGRRGRVVLPLPATMQTRSAQGLLATSKRQQLLTVSWISSQQRKLQYIIFEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M531</accession>
    <name>A0A2I3M531_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family member B5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MAGEB5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003917574.4">
        <property type="nucleotide sequence ID" value="XM_003917525.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M531"/>
    <dbReference type="STRING" id="9555.ENSPANP00000030749"/>
    <dbReference type="Ensembl" id="ENSPANT00000052114.2">
        <property type="protein sequence ID" value="ENSPANP00000030749.2"/>
        <property type="gene ID" value="ENSPANG00000035394.2"/>
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    <dbReference type="KEGG" id="panu:101012129"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035394">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Melanoma-associated antigen C2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="melanoma-associated antigen D1"/>
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        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
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    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
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    <dbReference type="InterPro" id="IPR021072">
        <property type="entry name" value="MAGE_N"/>
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    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
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    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
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    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
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    <dbReference type="PANTHER" id="PTHR11736:SF35">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN B5"/>
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    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
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        <property type="entry name" value="MAGE_N"/>
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        <property type="entry name" value="MAGE"/>
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        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="142"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030749.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="342" mass="39045" checksum="12E82DBBCC4B963E" modified="2022-05-25" version="2">MLITEGTTYTMSGNTTEFNCYSQPWDNEDRVNMSQDQNSKLHICEKHYQIQDDSQVQSGAQVSEEVDDEPLPTSSPVLGDIPQSSSAAESSGTSQEPCKSSTMTSAGIFNTGSDEGANSRDEEYPCSLEVSPFTESSCSNFINIKVGLLEQFLLYKFEMKQCILKEDMLKIVNPRYQNQFAEILRRASEHIEVVLAADLKEVHPTCYLYDPVSKLKLPNSRRIHAGKRLPKTGLLMTLLVVIFLKGNCANEEDIWKFLDMMQIYDGKKHYIYGEPRKFITQDFVRLKYLEYHWVPCSYPARYKFLCVPKAYTKTSKIRVLEYLAKVNDIAPVAFSSQYEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MQ03</accession>
    <name>A0A2I3MQ03_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transforming acidic coiled-coil containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TACC2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MQ03"/>
    <dbReference type="Ensembl" id="ENSPANT00000046841.2">
        <property type="protein sequence ID" value="ENSPANP00000037812.2"/>
        <property type="gene ID" value="ENSPANG00000020477.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157052"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020477">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MQ03">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF11">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="888"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="897"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037812.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119056" checksum="E3A48845BB3A009A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MTQ6</accession>
    <name>A0A2I3MTQ6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4 7">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HYI</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4 7"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MTQ6"/>
    <dbReference type="Ensembl" id="ENSPANT00000036103.2">
        <property type="protein sequence ID" value="ENSPANP00000039045.1"/>
        <property type="gene ID" value="ENSPANG00000002794.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005462"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002794">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000011">
        <property type="entry name" value="Putative hydroxypyruvate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="275" mass="30273" checksum="78267E5867D76A5C" modified="2018-02-28" version="1">MAPLRFSANLSWLFPELPGLPARLRAAGSSGFEAVEVAWPYAEPPEALARAAREAGLRLVLINTPPGDQEKGEMGLGAVPGRQAAFREGLEQAVRYAKALGCPRIHLMAGRVPQGADRIAVKAEMEIVFLENLRHAAGVLAEEDLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPNLQLQMDIFHWQIMDGNLTGNIQEFLPIVGHVQVAQVPGRGEPSSPGELNFPYLFQLLEDEGYKGFVGCEYQPRGEGWPWGRELWRDDRGCFLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MTU7</accession>
    <name>A0A2I3MTU7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear factor of activated T cells 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NFATC4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
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    <reference evidence="13" key="2">
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        <subcellularLocation>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4"/>
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    <dbReference type="Pfam" id="PF16179">
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        <property type="entry name" value="NUCFACTORATC"/>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="462"/>
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        </location>
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        <location>
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        <location>
            <begin position="38"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="11">
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            <begin position="111"/>
            <end position="142"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="157"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039184.2"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="961" mass="101433" checksum="78C2ECF2A6C0D287" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MY23</accession>
    <name>A0A2I3MY23_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 19">Solute carrier family 2, facilitated glucose transporter member 3</fullName>
            <shortName evidence="19">GLUT-3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glucose transporter type 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with SMIM43; the interaction may promote SLC2A3-mediated glucose transport to meet the energy needs of mesendoderm differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 19">Cell membrane</location>
            <topology evidence="4 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 19">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="19">Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_009198808.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197073.1">
        <property type="nucleotide sequence ID" value="XM_009198809.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197074.1">
        <property type="nucleotide sequence ID" value="XM_009198810.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197075.1">
        <property type="nucleotide sequence ID" value="XM_009198811.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197076.1">
        <property type="nucleotide sequence ID" value="XM_009198812.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197077.1">
        <property type="nucleotide sequence ID" value="XM_009198813.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197078.1">
        <property type="nucleotide sequence ID" value="XM_009198814.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197079.1">
        <property type="nucleotide sequence ID" value="XM_009198815.1"/>
    </dbReference>
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    <dbReference type="STRING" id="9555.ENSPANP00000040560"/>
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        <property type="protein sequence ID" value="ENSPANP00000040560.2"/>
        <property type="gene ID" value="ENSPANG00000023832.4"/>
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    <dbReference type="GeneID" id="101010379"/>
    <dbReference type="KEGG" id="panu:101010379"/>
    <dbReference type="GeneTree" id="ENSGT00940000162491"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023832">
        <property type="expression patterns" value="Expressed in adrenal medulla and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033300">
        <property type="term" value="F:dehydroascorbic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17431">
        <property type="entry name" value="MFS_GLUT_Class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000040">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002945">
        <property type="entry name" value="Glc_transpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF99">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01192">
        <property type="entry name" value="GLUCTRSPORT3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="21">
        <location>
            <begin position="14"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040560.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="497" mass="54318" checksum="57D5806CE3EC6040" modified="2022-05-25" version="2">MDNKPHVTPALIFAITVATIGSFQFGYNTGVINAPERIIKEFINKSLMEKANALPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVAGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLEFILGSEELWPMLLGFTILPAILQSATLPCCPESPRFLLINRKEEENAKRILQWLWGTQDVFQDIQEMKDESVRMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVEEPIYATIGAGVVNTVFTVVSLFLVERAGRRTLHMIGLGGMAVCSMLMTVSLLLKDTYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLIFTFFKVPETRGRTFEDITRAFEGQAQGANRSGKDAVMEMNSIQPPKETTSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N3L3</accession>
    <name>A0A2I3N3L3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cystatin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Stefin-B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Able to form dimers stabilized by noncovalent forces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009205417.1">
        <property type="nucleotide sequence ID" value="XM_009207153.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N3L3"/>
    <dbReference type="Ensembl" id="ENSPANT00000034813.2">
        <property type="protein sequence ID" value="ENSPANP00000042607.2"/>
        <property type="gene ID" value="ENSPANG00000045201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101017479"/>
    <dbReference type="KEGG" id="panu:101017479"/>
    <dbReference type="GeneTree" id="ENSGT00940000154826"/>
    <dbReference type="OMA" id="RTFFIKV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007154">
        <property type="expression patterns" value="Expressed in esophagus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N3L3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF22">
        <property type="entry name" value="CYSTATIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042607.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="98" mass="11231" checksum="FA8E0D03307B2176" modified="2022-05-25" version="2">MMCGAPSAVQPATAKTQYIADQVRSQLQEKENKKFPVFKAVWFKSQVVAGTNYFIKVHVGDENFVHLRVFISLPHENKPLTLSNYQTNKAKHDELSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NGF5</accession>
    <name>A0A2I3NGF5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stathmin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STMN4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stathmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902625.1">
        <property type="nucleotide sequence ID" value="XM_003902576.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NGF5"/>
    <dbReference type="SMR" id="A0A2I3NGF5"/>
    <dbReference type="Ensembl" id="ENSPANT00000057103.2">
        <property type="protein sequence ID" value="ENSPANP00000047068.1"/>
        <property type="gene ID" value="ENSPANG00000007322.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022696"/>
    <dbReference type="CTD" id="81551"/>
    <dbReference type="GeneTree" id="ENSGT01030000234597"/>
    <dbReference type="OrthoDB" id="5986631at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007322">
        <property type="expression patterns" value="Expressed in lateral globus pallidus and 41 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NGF5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF6">
        <property type="entry name" value="STATHMIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002285">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01041">
        <property type="entry name" value="STATHMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="216" mass="25418" checksum="9B9FCE70A39F20B0" modified="2018-02-28" version="1">MTLAAYKEKMKELPLVSLFCSCFLADPLNKSSYKYEGWCGRQCRRKDESQRKDSADWRERRAQADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NHN3</accession>
    <name>A0A2I3NHN3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Signal recognition particle 54 kDa protein</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SRP54</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13 15">Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003901747.1">
        <property type="nucleotide sequence ID" value="XM_003901698.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209652.1">
        <property type="nucleotide sequence ID" value="XM_009211388.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209653.1">
        <property type="nucleotide sequence ID" value="XM_009211389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NHN3"/>
    <dbReference type="SMR" id="A0A2I3NHN3"/>
    <dbReference type="Ensembl" id="ENSPANT00000052131.2">
        <property type="protein sequence ID" value="ENSPANP00000047592.1"/>
        <property type="gene ID" value="ENSPANG00000023853.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020102"/>
    <dbReference type="KEGG" id="panu:101020102"/>
    <dbReference type="CTD" id="6729"/>
    <dbReference type="GeneTree" id="ENSGT00550000074824"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023853">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NHN3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030851">
        <property type="term" value="P:granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="16">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="504" mass="55705" checksum="7D7630A43BC5EC2C" modified="2018-02-28" version="1">MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXQ3</accession>
    <name>A0A8I5MXQ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transforming growth factor beta activator LRRC33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Negative regulator of reactive oxygen species</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NRROS</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LRRC32/LRRC33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXQ3"/>
    <dbReference type="Ensembl" id="ENSPANT00000061253.1">
        <property type="protein sequence ID" value="ENSPANP00000050500.1"/>
        <property type="gene ID" value="ENSPANG00000009262.3"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Transforming growth factor beta activator LRRC33"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.80.10.10:FF:000684">
        <property type="entry name" value="Transforming growth factor beta activator LRRC33"/>
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    <dbReference type="FunFam" id="3.80.10.10:FF:000806">
        <property type="entry name" value="Transforming growth factor beta activator LRRC33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266257" description="Transforming growth factor beta activator LRRC33" evidence="19">
        <location>
            <begin position="20"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="692" mass="76572" checksum="A688EF7F26CA0DC4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MYV0</accession>
    <name>A0A8I5MYV0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dr1-associated corepressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dr1-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Negative cofactor 2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DRAP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Heterodimer with DR1. Binds BTAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MYV0"/>
    <dbReference type="Ensembl" id="ENSPANT00000083254.1">
        <property type="protein sequence ID" value="ENSPANP00000047963.1"/>
        <property type="gene ID" value="ENSPANG00000013679.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012424"/>
    <dbReference type="OMA" id="TEVEPAH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001091">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000032">
        <property type="entry name" value="dr1-associated corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="14">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="212" mass="23215" checksum="4F6CA30F89941639" modified="2022-05-25" version="1">MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRWTVPSQRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPPAHFQSPPTPFLPFASTLPLPPAPPGPSAPDEEDEEDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZ61</accession>
    <name>A0A8I5MZ61_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZ61"/>
    <dbReference type="Ensembl" id="ENSPANT00000083703.1">
        <property type="protein sequence ID" value="ENSPANP00000051382.1"/>
        <property type="gene ID" value="ENSPANG00000037933.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF154">
        <property type="entry name" value="PROTEIN-SERINE_THREONINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="291" mass="31677" checksum="F23CE3ECB4D0F47A" modified="2022-05-25" version="1">MSTIHSQIPFHQPPPLFPLPSPLPLPSFPPPLPLLPPFLFPRPPPPSSSSSFFLLLSSSSSSSSFFFLLPFFVRQSLPLSPRLECSGAISAHCSLCLLGSSDSPASVSQVAGITGMCHHTLLIFVFFIFYHVEQAGLEPLTSSDPPASASQSAGISNPADTSDSLFSLFPTLPSCGVPSEALLRRRAVRSWAALPGGRREGQVCGGVHRCLSRPGRPPLHHLRRPSLRHDGHLFVHDGRAVWRRRHPACLQRGGQERAPGQPPRLLRGPRHCARLQPLRVADPRGSWLRPS</sequence>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0N6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0N6"/>
    <dbReference type="Ensembl" id="ENSPANT00000079989.1">
        <property type="protein sequence ID" value="ENSPANP00000048920.1"/>
        <property type="gene ID" value="ENSPANG00000046206.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287003"/>
    <dbReference type="OMA" id="WKTIWRS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="186" mass="21802" checksum="35A46ED4F6036C03" modified="2022-05-25" version="1">MGKDFMSKTPKATAAKAKIDKWDLIKPKSFCTAKETTIRVNRQPTEWEKIFAIYSSDKGLISRTYKELKQIYKKKTNNPIKKWAKDMNRHFSKEDIHTANRHMKKCSSSLAIREMQIKTTMRYHLTPVRMAIIKKSGNNRCWRGCGEIGTLLHCWWDCKLVQPLWKTIWRSFKSQETTGAGEDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0R1</accession>
    <name>A0A8I5N0R1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RasGEF domain family member 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RASGEF1B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0R1"/>
    <dbReference type="Ensembl" id="ENSPANT00000076309.1">
        <property type="protein sequence ID" value="ENSPANP00000051471.1"/>
        <property type="gene ID" value="ENSPANG00000018336.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155816"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000008">
        <property type="entry name" value="Ras-GEF domain-containing family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000007">
        <property type="entry name" value="Ras-GEF domain-containing family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF197">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="211"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="479" mass="56003" checksum="994A8503E38976F2" modified="2022-05-25" version="1">MIIKKESMPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKGPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLITVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N189</accession>
    <name>A0A8I5N189_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal peptide peptidase like 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SPPL2A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N189"/>
    <dbReference type="Ensembl" id="ENSPANT00000070682.1">
        <property type="protein sequence ID" value="ENSPANP00000052704.1"/>
        <property type="gene ID" value="ENSPANG00000017548.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157722"/>
    <dbReference type="OMA" id="FFEESIM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF34">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="291" mass="32400" checksum="22465BA2256CDD77" modified="2022-05-25" version="1">MIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKSMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKNDGNLVEATGQPSAPHEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASIVAWRRKEMKKFWKGNSYQMMDHLDYAANEENPALTGEQIVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1G1</accession>
    <name>A0A8I5N1G1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Interferon alpha 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IFNA14</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N1G1"/>
    <dbReference type="Ensembl" id="ENSPANT00000062424.1">
        <property type="protein sequence ID" value="ENSPANP00000052824.1"/>
        <property type="gene ID" value="ENSPANG00000041833.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214430"/>
    <dbReference type="OMA" id="NNRRTLM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00095">
        <property type="entry name" value="IFab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000001">
        <property type="entry name" value="Interferon alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF67">
        <property type="entry name" value="INTERFERON ALPHA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00266">
        <property type="entry name" value="INTERFERONAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00076">
        <property type="entry name" value="IFabd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00252">
        <property type="entry name" value="INTERFERON_A_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3 7" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035298035" evidence="8">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="189" mass="22098" checksum="FA71E305E5A8BAEC" modified="2022-05-25" version="1">MALPFALMMALLVLSYKSSCSLGCNLSQTHNMNNRRTLMLMAQMRRISPFSCLKDRNDFEFPQEEFDGNQFQNTQAISVLHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLEACVIQEAGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N3T3</accession>
    <name>A0A8I5N3T3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Nerve injury-induced gene 283 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ZNRF1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with AKT1, GLUL and TUBB2A. Interacts with ZNRF2. Interacts (via its RING domain) with UBE2N. Interacts (when phosphorylated) with YWHAE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasmic vesicle</location>
            <location evidence="16">Secretory vesicle</location>
            <location evidence="16">Synaptic vesicle membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003917226.1">
        <property type="nucleotide sequence ID" value="XM_003917177.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195128.1">
        <property type="nucleotide sequence ID" value="XM_009196864.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195129.1">
        <property type="nucleotide sequence ID" value="XM_009196865.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N3T3"/>
    <dbReference type="Ensembl" id="ENSPANT00000061859.1">
        <property type="protein sequence ID" value="ENSPANP00000054396.1"/>
        <property type="gene ID" value="ENSPANG00000034015.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101011193"/>
    <dbReference type="KEGG" id="panu:101011193"/>
    <dbReference type="CTD" id="84937"/>
    <dbReference type="GeneTree" id="ENSGT00940000159278"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16695">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="227" mass="23813" checksum="A5BCF1AAF9D0CA41" modified="2022-05-25" version="1">MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNGYQETGGSHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N5G3</accession>
    <name>A0A8I5N5G3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N5G3"/>
    <dbReference type="Ensembl" id="ENSPANT00000083873.1">
        <property type="protein sequence ID" value="ENSPANP00000055380.1"/>
        <property type="gene ID" value="ENSPANG00000040109.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="ITIREYY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="356"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1094" mass="128234" checksum="4F8D272CDA1C0E3B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N6F9</accession>
    <name>A0A8I5N6F9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Regulating synaptic membrane exocytosis 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RIMS2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000048329.1"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0050806">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042391">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:2000300">
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        <property type="project" value="TreeGrafter"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1554" mass="176674" checksum="2693CD1090010C5F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N839</accession>
    <name>A0A8I5N839_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Prokineticin receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PROKR1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021780589.2">
        <property type="nucleotide sequence ID" value="XM_021924897.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511100.1">
        <property type="nucleotide sequence ID" value="XM_031655240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N839"/>
    <dbReference type="Ensembl" id="ENSPANT00000081789.1">
        <property type="protein sequence ID" value="ENSPANP00000048107.1"/>
        <property type="gene ID" value="ENSPANG00000048102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101009361"/>
    <dbReference type="KEGG" id="panu:101009361"/>
    <dbReference type="CTD" id="10887"/>
    <dbReference type="GeneTree" id="ENSGT00940000154544"/>
    <dbReference type="OMA" id="HGHVMCA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15204">
        <property type="entry name" value="7tmA_prokineticin-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000069">
        <property type="entry name" value="Prokineticin receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF74">
        <property type="entry name" value="PROKINETICIN RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="88"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="402" mass="45666" checksum="5D92B810E47AA342" modified="2022-05-25" version="1">MLLTAPPGQMETTMGFMDDNATNTSTSFLSALNPHGAHAASFPFNFSYGDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFVFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLLIVRSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVFTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNNTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NAU2</accession>
    <name>A0A8I5NAU2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TAS2R16</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with RTP3 and RTP4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="15">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 14">Belongs to the G-protein coupled receptor T2R family.</text>
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        <property type="entry name" value="TAS2R"/>
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        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 16"/>
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    <keyword evidence="5 15" id="KW-0716">Sensory transduction</keyword>
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    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="229"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="291" mass="34051" checksum="BEBD7D00BEC27511" modified="2022-05-25" version="1">MIPIQLSVFFMIIYVLESLTIIVQSSLIVAVLGREWLQIRRLMPVDMILISLGISRFCLQWTSMLNDFCFYFNFNYVLCNLTITWTFFNVLTFWLNSLLTVFYCIKVSSFTHPIVLWLRWRILRWLPWLLLGCLMITCVTIIPSAIGNYIQIQFLTMEHPPRNSTVIDRLQKFHQYLHQAHTVALVIPFILFLASTILLMASLTKQIQHHGTGHCNPSMKAHFTALRSLAILFIVFTSYFLTILITMIGTLFDKRCWLWVWEAFVYAFIFMHSTSLMLSSPTLKRILNGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NAX0</accession>
    <name>A0A8I5NAX0_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RT_nLTR_like"/>
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        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RT_POL"/>
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        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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            <end position="341"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="784" mass="90758" checksum="C7F5D270EF777A9F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC30</accession>
    <name>A0A8I5NC30_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
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    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC30"/>
    <dbReference type="Ensembl" id="ENSPANT00000076149.1">
        <property type="protein sequence ID" value="ENSPANP00000054395.1"/>
        <property type="gene ID" value="ENSPANG00000042740.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="FCMAKVT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1275" mass="149199" checksum="075C53FAF6829F3E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGF0</accession>
    <name>A0A8I5NGF0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGF0"/>
    <dbReference type="Ensembl" id="ENSPANT00000068733.1">
        <property type="protein sequence ID" value="ENSPANP00000057291.1"/>
        <property type="gene ID" value="ENSPANG00000037666.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000082643.1">
        <property type="protein sequence ID" value="ENSPANP00000059778.1"/>
        <property type="gene ID" value="ENSPANG00000038586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017974"/>
    <dbReference type="OMA" id="MMHYKEE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21937">
        <property type="entry name" value="ZIP_MycBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11996" checksum="460CF4768FB9E963" modified="2022-05-25" version="1">MAYYKATDSKCEQFQRYLEKLRVLDTLTKVLVALYKEPEKPNSALDFLKHRLGAATPENPEIELLRLELTEMKEKSEATVEVNKKLKAKLAQYEPPQEKKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJG1</accession>
    <name>A0A8I5NJG1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUBGCP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. Plays a role in neuronal migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000057899.1"/>
        <property type="gene ID" value="ENSPANG00000020122.3"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="term" value="C:centrosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
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    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:neuron migration"/>
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    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000002">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="11">
        <location>
            <begin position="218"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="10">
        <location>
            <begin position="509"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="887"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="940" mass="105970" checksum="07ADFA839E167161" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NK15</accession>
    <name>A0A8I5NK15_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
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        <property type="protein sequence ID" value="ENSPANP00000055942.1"/>
        <property type="gene ID" value="ENSPANG00000049897.1"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055942.1"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
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        <property type="entry name" value="Retroviral GAG p10 protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Primate_lentivir_Gag_pol-like"/>
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        <property type="entry name" value="Retrov_capsid_C"/>
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        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
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            <end position="91"/>
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    <feature type="domain" description="Retroviral nucleocapsid Gag protein p24 C-terminal" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF19317"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSPANP00000061269.1"/>
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        <property type="entry name" value="AN1-like Zinc finger"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
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    <feature type="domain" description="AN1-type" evidence="9">
        <location>
            <begin position="182"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        <location>
            <begin position="72"/>
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            <begin position="144"/>
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            <begin position="16"/>
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            <begin position="80"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    <accession>A0A8I5NY46</accession>
    <name>A0A8I5NY46_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="95" mass="10845" checksum="B94AF920D04EDB59" modified="2022-05-25" version="1">LNQIIICDQVLVAADFSFFFFFFFFEAESRSVAQAGVQWPDLSSLQALPPGFTPFSCLSLPSSWDYRRRHHARLVFLVQTGFHRVSQDGLDLLTS</sequence>
</entry>
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    <accession>A0A8I5P4I8</accession>
    <name>A0A8I5P4I8_PAPAN</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 18 open reading frame 32</fullName>
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    <gene>
        <name evidence="5" type="primary">C18orf32</name>
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    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May activate the NF-kappa-B signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with DERL1 and AMFR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0729 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5P4I8"/>
    <dbReference type="Ensembl" id="ENSPANT00000068402.1">
        <property type="protein sequence ID" value="ENSPANP00000061212.1"/>
        <property type="gene ID" value="ENSPANG00000040941.1"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101011751"/>
    <dbReference type="GeneTree" id="ENSGT00390000018741"/>
    <dbReference type="OMA" id="SRIWPGK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026776">
        <property type="entry name" value="UPF0729_C18orf32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456:SF0">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14975">
        <property type="entry name" value="DUF4512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="D63EF7B3A5C5EFA1" modified="2022-05-25" version="1">MVCIPCIVIPVLLWIYKKFLEPYIYPLISPFVGRIWPKKAIQESNDPNKGKVDCKGADMNGLPTKGPTEISDKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZ96</accession>
    <name>A0A8I5QZ96_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZ96"/>
    <dbReference type="Ensembl" id="ENSPANT00000075444.1">
        <property type="protein sequence ID" value="ENSPANP00000048502.1"/>
        <property type="gene ID" value="ENSPANG00000040522.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286940"/>
    <dbReference type="OMA" id="LQQMPYH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15953">
        <property type="entry name" value="7tmA_OR52P-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF132">
        <property type="entry name" value="OLFACTORY RECEPTOR 654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="85"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="368" mass="41418" checksum="FCECF2FA99DA200D" modified="2022-05-25" version="1">MQFPLLRGENDWMKLTLISLLESRIFEPLRLAFNKVLQQGATMTACNASQGHLSFFILQGIPGMEDKHRWISIPFSSMYFITVLGNCTILLTVSTERSLHKPMFLLLCLLALTDLGMSTTTIPKVLCIFWFRQSEISYEGCLVQLFFIYSISAMQSAILMTMAFDCYVAICKPLHYATILSNSCIGLISLVSLVRAILFILPMPILLQQMPYHANHVIPTTYCEHMAVVKMVCVDTTVNRIYGLVVALLVVGLDLSAIASSYVLIIQAIMCLSSKEAHHKAVNTCTTHICVMLISYTPSLFSFLTHRFGQGIPAHVHIILGSLYFLIPPMLNPIIYGVKTKEFRDKVTKYGCWKREPTTTARGQKLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R046</accession>
    <name>A0A8I5R046_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="9">HIB-CoA hydrolase</shortName>
            <shortName evidence="9">HIBYL-CoA-H</shortName>
            <ecNumber evidence="9">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HIBCH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031507272.1">
        <property type="nucleotide sequence ID" value="XM_031651412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R046"/>
    <dbReference type="Ensembl" id="ENSPANT00000077015.1">
        <property type="protein sequence ID" value="ENSPANP00000051263.1"/>
        <property type="gene ID" value="ENSPANG00000005726.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003898"/>
    <dbReference type="CTD" id="26275"/>
    <dbReference type="GeneTree" id="ENSGT00890000139491"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="386" mass="43450" checksum="4F7463585486B281" modified="2022-05-25" version="1">MGQREVWRLMSRFNAFKRTNTILHHLRMSKHTDAAEDVLLEKKGCAGVITLNRPKLLNTLTFNMIRQIYSQLKKWEQDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQNIAPVFFRVEYMLNNAIGSCQKPYVALIHGITMGGGVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLENYHTESKIDRDKSFMLEEHMDKINSCFSANTVEEIIENLKQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTDEDLNNHFKSLGSHDLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R1R8</accession>
    <name>A0A8I5R1R8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">OR14K1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R1R8"/>
    <dbReference type="Ensembl" id="ENSPANT00000076585.1">
        <property type="protein sequence ID" value="ENSPANP00000056905.1"/>
        <property type="gene ID" value="ENSPANG00000046872.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244828"/>
    <dbReference type="OMA" id="CVQLMAL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15227">
        <property type="entry name" value="7tmA_OR14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000037">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="314" mass="34895" checksum="32F46059CAF16947" modified="2022-05-25" version="1">MTNQTQMMEFFLMRFTENWMLLRLHAVLFSLIYLAAVLMNLVIILLTILDHRLHMAMYFFLRHLSFLDLCLISATVPKSILNSVTSTDSISFLGCVLQLFVVVLLAGSEIGILTAMSYDRYAAICRPLHYEAVMSRGLCVQLMALSWLNGGALGLLYTAGTFSLNFCGFKEIHQFFCDVPALLKLTCSKEHGIISVSVTIGVCYAFSCLVCIVVSYVYIFSAVLRISPRQRQSKAFSNCVPHLIVVTVFLVTGAVAYLKPGSDAPSIPDLLVSVFYSVAPPALNPVIYCLRNKDIKSALSKVLWNVRSSGVMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R278</accession>
    <name>A0A8I5R278_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPANT00000068129.1">
        <property type="protein sequence ID" value="ENSPANP00000058526.1"/>
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    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166898"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF157">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="142" mass="15199" checksum="820361D6D7405AEF" modified="2022-05-25" version="1">LPSPESKIKGPTSTSWISRRTPPNGAHAFPFDRPGKHRCLGKERSGSGFQRWAGGLTKHLNVPFGDGIEAAAGEQDNDLTLSSRLECSGMISAHHSLDFLDSSNPPTSASQVAGTTGVCHHAQLIFHVFCRDGVSLYCPGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2A9</accession>
    <name>A0A8I5R2A9_PAPAN</name>
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        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
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                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSPANT00000067091.1">
        <property type="protein sequence ID" value="ENSPANP00000058886.1"/>
        <property type="gene ID" value="ENSPANG00000039374.1"/>
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    <dbReference type="OMA" id="YSAIPIH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Immunoglobulin lambda locus"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="111" mass="12022" checksum="D3C58B4068F9D8A1" modified="2022-05-25" version="1">SYELTQPPSVSVSPGQMARITCSGDTLAKKYAQWFQQKPGQAPVLVIYKDSERPSGIPERFSSSSSGTTVTLTISGAQAEDEADYYCQSNVGDNSKTLECHEKMPIALCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6A3</accession>
    <name>A0A8I5R6A3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6A3"/>
    <dbReference type="Ensembl" id="ENSPANT00000077795.1">
        <property type="protein sequence ID" value="ENSPANP00000051667.1"/>
        <property type="gene ID" value="ENSPANG00000049297.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="71" mass="7743" checksum="31BA9ADB40944236" modified="2022-05-25" version="1">TVSRSVVQAGVQWHDLGSLQAPPPGFTPLSCLSLLSSLDYRCPPPRLANFCIFIETGFHHVSQDGLYLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6Z0</accession>
    <name>A0A8I5R6Z0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6Z0"/>
    <dbReference type="Ensembl" id="ENSPANT00000074124.1">
        <property type="protein sequence ID" value="ENSPANP00000052856.1"/>
        <property type="gene ID" value="ENSPANG00000038612.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000153255"/>
    <dbReference type="OMA" id="TCGHSEC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15420">
        <property type="entry name" value="7tmA_OR2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="311" mass="35043" checksum="3780F90F6ABE2827" modified="2022-05-25" version="1">MGENQTMVTEFLLLGFLLDPRIQMLLFGLLSLFHVFTLLGNGAILGLISLDSRLHTPMYFFLSHLAVVDITYACNMVPQMLVNLLHPAKPISFAGCMMQTFLCLTCGHSECLLLVVMSYDRYVAICHPLRYSIIVTWRVCITLAITSWTCGSLLALVHVVLILRLPFCGPYEINHFFCEILSVLRLACADTWLNQVVIFAACVFFLVGPLCLVLVSYLHILTAILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIIMYMAPKSRHPEELQKVLFLFYSFFNPTLNPLIYSLRNAEVKGALRRALCKESHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R8M2</accession>
    <name>A0A8I5R8M2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R8M2"/>
    <dbReference type="Ensembl" id="ENSPANT00000062335.1">
        <property type="protein sequence ID" value="ENSPANP00000056636.1"/>
        <property type="gene ID" value="ENSPANG00000046187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="EMEHAHR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="15">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="14">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="16">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="39709" checksum="2CAD15804A5A10F9" modified="2022-05-25" version="1">MGKKQGRKAGNSKNKSTSPPAKERSSSPVMDQSWTENDFDKMREQGFSPSNFSELKEELRTQRKETKNLEKKVEELMARVINAEKVIDEMKEMKTMTREIRDKCTSFSNRLDQLEERVSAIEDQMNEMKREEKPKEKRRKRNEQSLQEVWDYVKRPNLRLIGVPESEGENGTKLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSSRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTADLSAETLQARREWGPIFNILKEKNFKPRISYPAKLSFISEGEIKSFTDKQMLRDFVTTRPALQETLKEALNMERNNRYQPLQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5RA01</accession>
    <name>A0A8I5RA01_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021779474.1">
        <property type="nucleotide sequence ID" value="XM_021923782.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5RA01"/>
    <dbReference type="Ensembl" id="ENSPANT00000080381.1">
        <property type="protein sequence ID" value="ENSPANP00000060611.1"/>
        <property type="gene ID" value="ENSPANG00000048530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101023913"/>
    <dbReference type="KEGG" id="panu:101023913"/>
    <dbReference type="GeneTree" id="ENSGT00950000183301"/>
    <dbReference type="OMA" id="PTEMSCQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028205">
        <property type="entry name" value="LCE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14672">
        <property type="entry name" value="LCE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0417">Keratinization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="118" mass="11587" checksum="D94BA923D56C2618" modified="2022-05-25" version="1">MSCQQSQQQCQPPPKCTPKCPPKCPAPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCCGSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSDCCSQPSGGSSCCGGGSGQHSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MN16</accession>
    <name>A0A096MN16_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">VWFA and cache domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CACHD1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May regulate voltage-dependent calcium channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel subunit alpha-2/delta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031525357.1">
        <property type="nucleotide sequence ID" value="XM_031669497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MN16"/>
    <dbReference type="SMR" id="A0A096MN16"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001007"/>
    <dbReference type="Ensembl" id="ENSPANT00000006633.3">
        <property type="protein sequence ID" value="ENSPANP00000001007.3"/>
        <property type="gene ID" value="ENSPANG00000010808.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002520"/>
    <dbReference type="CTD" id="57685"/>
    <dbReference type="eggNOG" id="KOG2353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157568"/>
    <dbReference type="HOGENOM" id="CLU_004521_0_0_1"/>
    <dbReference type="OMA" id="NTHPYLS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010808">
        <property type="expression patterns" value="Expressed in iris and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000024">
        <property type="entry name" value="VWFA and cache domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000029">
        <property type="entry name" value="VWFA and cache domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000039">
        <property type="entry name" value="VWFA and cache domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF68">
        <property type="entry name" value="VWFA AND CACHE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="Sensory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286310" description="VWFA and cache domain-containing protein 1" evidence="17">
        <location>
            <begin position="38"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1096"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="228"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1179"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001007.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1274" mass="142206" checksum="69BAA3AA74239127" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNI3</accession>
    <name>A0A096MNI3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Apelin receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Angiotensin receptor-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">G-protein coupled receptor APJ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">APLNR</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer; dimerization inhibits APLNR-mediated G protein and beta-arrestin signaling pathways compared to monomeric APLNR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909915.1">
        <property type="nucleotide sequence ID" value="XM_003909866.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNI3"/>
    <dbReference type="SMR" id="A0A096MNI3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001209"/>
    <dbReference type="Ensembl" id="ENSPANT00000001988.3">
        <property type="protein sequence ID" value="ENSPANP00000001209.1"/>
        <property type="gene ID" value="ENSPANG00000014067.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025565"/>
    <dbReference type="KEGG" id="panu:101025565"/>
    <dbReference type="CTD" id="187"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278303"/>
    <dbReference type="HOGENOM" id="CLU_009579_8_1_1"/>
    <dbReference type="OMA" id="YAWLGYH"/>
    <dbReference type="OrthoDB" id="5974286at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014067">
        <property type="expression patterns" value="Expressed in habenula and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060182">
        <property type="term" value="F:apelin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140897">
        <property type="term" value="F:mechanoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007512">
        <property type="term" value="P:adult heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003171">
        <property type="term" value="P:atrioventricular valve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003272">
        <property type="term" value="P:endocardial cushion formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:gastrulation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:heart looping"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043951">
        <property type="term" value="P:negative regulation of cAMP-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of angiogenesis"/>
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        <property type="term" value="P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of G protein-coupled receptor internalization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051281">
        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1903596">
        <property type="term" value="P:regulation of gap junction assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035886">
        <property type="term" value="P:vascular associated smooth muscle cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060841">
        <property type="term" value="P:venous blood vessel development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="7tmA_Apelin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000106">
        <property type="entry name" value="Apelin receptor a"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003904">
        <property type="entry name" value="Apelin_rcpt"/>
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    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF953">
        <property type="entry name" value="APELIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01416">
        <property type="entry name" value="APJRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0306">Gastrulation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="21">
        <location>
            <begin position="45"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="342"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="380" mass="42606" checksum="E84F03E31FABF7ED" modified="2014-11-26" version="1">MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVFRTTGDLENTTKVQCYMDYSMVATVSSDWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNR1</accession>
    <name>A0A096MNR1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oxoeicosanoid receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OXER1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003919570.1">
        <property type="nucleotide sequence ID" value="XM_003919521.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNR1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001323"/>
    <dbReference type="Ensembl" id="ENSPANT00000008383.3">
        <property type="protein sequence ID" value="ENSPANP00000001323.2"/>
        <property type="gene ID" value="ENSPANG00000017325.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005199"/>
    <dbReference type="KEGG" id="panu:101005199"/>
    <dbReference type="CTD" id="165140"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282516"/>
    <dbReference type="HOGENOM" id="CLU_009579_8_2_1"/>
    <dbReference type="OMA" id="ACKINLF"/>
    <dbReference type="OrthoDB" id="10055255at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017325">
        <property type="expression patterns" value="Expressed in bone marrow and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050648">
        <property type="term" value="F:5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050647">
        <property type="term" value="F:5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050646">
        <property type="term" value="F:5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15200">
        <property type="entry name" value="7tmA_OXER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051893">
        <property type="entry name" value="HCARs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46048">
        <property type="entry name" value="HYDROXYCARBOXYLIC ACID RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46048:SF1">
        <property type="entry name" value="OXOEICOSANOID RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="109"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001323.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="423" mass="45684" checksum="FF21221DFD282195" modified="2018-02-28" version="2">MLCHRGGRLIVSIIPLCPGHSCRGRRLQNLLSGPWLKQPMELHNLSSPSPSPSSSVLPPSFPPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLAFFIFCVHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAPACKINLFMLSTNRTASVVFLTAIALNRYLKVVQPHHALSRASVGAAARVAGGLWVGILLLNGHLLLGTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRSRGLGGQAGPQRAMRVLAVVVAVYTICFLPSIIFGMASMVAFWLSACRSLDVCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRHREASRKAEAIGKLEVQAEVSLEKEGSSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MP35</accession>
    <name>A0A096MP35_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MP35"/>
    <dbReference type="Ensembl" id="ENSPANT00000015331.3">
        <property type="protein sequence ID" value="ENSPANP00000001474.3"/>
        <property type="gene ID" value="ENSPANG00000011006.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000184991"/>
    <dbReference type="HOGENOM" id="CLU_096618_1_1_1"/>
    <dbReference type="OMA" id="HHSVVTM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011006">
        <property type="expression patterns" value="Expressed in pancreas and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MP35">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146783" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001474.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="84" mass="9616" checksum="0F2FCCF3D6AB8DAD" modified="2022-05-25" version="3">MAVVWRLTALCGAQGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPRHHSGSKLLLTMFMGMPRRKLPRQGFWHFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MR78</accession>
    <name>A0A096MR78_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">2-hydroxyacylsphingosine 1-beta-galactosyltransferase</fullName>
            <ecNumber evidence="22">2.4.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Ceramide UDP-galactosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Cerebroside synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">UDP-galactose-ceramide galactosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">UGT8</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:83244"/>
            <dbReference type="ChEBI" id="CHEBI:83246"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:43401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43404"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:83248"/>
            <dbReference type="ChEBI" id="CHEBI:83257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36498"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:13094"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21">Sphingolipid metabolism; galactosylceramide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.47" evidence="22"/>
    <dbReference type="RefSeq" id="XP_003899163.1">
        <property type="nucleotide sequence ID" value="XM_003899114.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MR78"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002273"/>
    <dbReference type="Ensembl" id="ENSPANT00000019719.3">
        <property type="protein sequence ID" value="ENSPANP00000002273.1"/>
        <property type="gene ID" value="ENSPANG00000017462.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011998"/>
    <dbReference type="KEGG" id="panu:101011998"/>
    <dbReference type="CTD" id="7368"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156545"/>
    <dbReference type="HOGENOM" id="CLU_012949_3_1_1"/>
    <dbReference type="OMA" id="WKYEGSA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017462">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003851">
        <property type="term" value="F:N-acylsphingosine galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000033">
        <property type="entry name" value="2-hydroxyacylsphingosine 1-beta-galactosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF54">
        <property type="entry name" value="2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 27" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 27" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00066508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="541" mass="61554" checksum="0F28B001D6F5AC89" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MSI5</accession>
    <name>A0A096MSI5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COMMD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017803057.1">
        <property type="nucleotide sequence ID" value="XM_017947568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MSI5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002754"/>
    <dbReference type="Ensembl" id="ENSPANT00000025606.3">
        <property type="protein sequence ID" value="ENSPANP00000002754.2"/>
        <property type="gene ID" value="ENSPANG00000006093.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013646"/>
    <dbReference type="KEGG" id="panu:101013646"/>
    <dbReference type="CTD" id="150684"/>
    <dbReference type="eggNOG" id="ENOG502RXN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012029"/>
    <dbReference type="HOGENOM" id="CLU_126878_0_0_1"/>
    <dbReference type="OMA" id="MPTAIVE"/>
    <dbReference type="OrthoDB" id="10251426at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006093">
        <property type="expression patterns" value="Expressed in heart and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034383">
        <property type="term" value="P:low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902072">
        <property type="term" value="P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902306">
        <property type="term" value="P:negative regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048227">
        <property type="term" value="P:plasma membrane to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904109">
        <property type="term" value="P:positive regulation of cholesterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905751">
        <property type="term" value="P:positive regulation of endosome to plasma membrane protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04749">
        <property type="entry name" value="Commd1_MURR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033776">
        <property type="entry name" value="COMMD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037351">
        <property type="entry name" value="Murr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17221">
        <property type="entry name" value="COMMD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002754.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="190" mass="21243" checksum="A2C13DCBBAD28743" modified="2018-02-28" version="2">MAAGEFEGGKPLNGLLNALAQDTFHGHPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKMLSEVEESISTLISQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MSY8</accession>
    <name>A0A096MSY8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SCCPDH</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MSY8"/>
    <dbReference type="SMR" id="A0A096MSY8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002912"/>
    <dbReference type="Ensembl" id="ENSPANT00000011267.4">
        <property type="protein sequence ID" value="ENSPANP00000002912.2"/>
        <property type="gene ID" value="ENSPANG00000008136.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004799"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008136">
        <property type="expression patterns" value="Expressed in perirenal fat and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MSY8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002912.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="421" mass="46299" checksum="DDA0C28BEC47DAA2" modified="2022-05-25" version="2">MATEQRPFHLVVFGASGFTGQFVTEEVAREQVDPERSSRLPWAVAGRSREKLQRVLEKAALKLGRPTLSSEVGIIICDIANPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNASNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVKRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGLGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLNDASDLPKAGGVFTPGAAFSKTKLIDRLNKHGVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTN6</accession>
    <name>A0A096MTN6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein inhibitor of activated STAT 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PIAS2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009190941.1">
        <property type="nucleotide sequence ID" value="XM_009192677.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTN6"/>
    <dbReference type="Ensembl" id="ENSPANT00000001437.3">
        <property type="protein sequence ID" value="ENSPANP00000003177.3"/>
        <property type="gene ID" value="ENSPANG00000016213.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101000815"/>
    <dbReference type="CTD" id="9063"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234539"/>
    <dbReference type="OMA" id="DPQQYCP"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016213">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16819">
        <property type="entry name" value="SP-RING_PIAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.780:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000003">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF12">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE PIAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="18">
        <location>
            <begin position="134"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="17">
        <location>
            <begin position="331"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="579"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003177.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="621" mass="68270" checksum="26F6B383345E6489" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTN8</accession>
    <name>A0A096MTN8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase 40</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">STK40</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A096MTN8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003179"/>
    <dbReference type="Ensembl" id="ENSPANT00000014446.3">
        <property type="protein sequence ID" value="ENSPANP00000003179.2"/>
        <property type="gene ID" value="ENSPANG00000026394.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182986"/>
    <dbReference type="HOGENOM" id="CLU_035107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026394">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048286">
        <property type="term" value="P:lung alveolus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060425">
        <property type="term" value="P:lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13974">
        <property type="entry name" value="STKc_SHIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000269">
        <property type="entry name" value="Serine/threonine-protein kinase 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024236">
        <property type="entry name" value="Ser/Thr_kinase_40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="40"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003179.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="440" mass="49515" checksum="6DED6C9F1B808FF7" modified="2022-05-25" version="2">MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILALCAVGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSNVDSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHDARSWVPKRQFGSVPPVRRLGHDAQPMTSLDTAILAQRYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTR0</accession>
    <name>A0A096MTR0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutaredoxin domain-containing cysteine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GRXCR1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in actin filament architecture in developing stereocilia of sensory cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Stereocilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GRXCR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017814155.1">
        <property type="nucleotide sequence ID" value="XM_017958666.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTR0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003201"/>
    <dbReference type="Ensembl" id="ENSPANT00000008254.3">
        <property type="protein sequence ID" value="ENSPANP00000003201.2"/>
        <property type="gene ID" value="ENSPANG00000021591.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020322"/>
    <dbReference type="KEGG" id="panu:101020322"/>
    <dbReference type="CTD" id="389207"/>
    <dbReference type="eggNOG" id="KOG2824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159219"/>
    <dbReference type="HOGENOM" id="CLU_067117_0_0_1"/>
    <dbReference type="OMA" id="ACHGSKM"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021591">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090102">
        <property type="term" value="P:cochlea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905144">
        <property type="term" value="P:response to acetylcholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060118">
        <property type="term" value="P:vestibular receptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03031">
        <property type="entry name" value="GRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000178">
        <property type="entry name" value="glutaredoxin domain-containing cysteine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042797">
        <property type="entry name" value="GRXCR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46990">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46990:SF1">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23733">
        <property type="entry name" value="GRXCR1-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-1009">Hearing</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="11">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003201.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="296" mass="33098" checksum="7279203B87FFE763" modified="2022-05-25" version="2">MWVEVTMLKREMKPESDRPRKVRFRIASSHSGRVLKEVYEDGQPSGSLDSECASICGIDGLSDSDGQQNGHIESEGDENENDQDSLLVLARAASEKGFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSTDLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGEYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSMCHGSKMSVFRNCFTDSFKALKCTACNENGLQRCKNCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MU67</accession>
    <name>A0A096MU67_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003907224.1">
        <property type="nucleotide sequence ID" value="XM_003907175.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MU67"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003364"/>
    <dbReference type="Ensembl" id="ENSPANT00000014904.3">
        <property type="protein sequence ID" value="ENSPANP00000003364.2"/>
        <property type="gene ID" value="ENSPANG00000019667.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004017"/>
    <dbReference type="KEGG" id="panu:101004017"/>
    <dbReference type="CTD" id="89894"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003209"/>
    <dbReference type="HOGENOM" id="CLU_057808_1_0_1"/>
    <dbReference type="OMA" id="YTISYIW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019667">
        <property type="expression patterns" value="Expressed in liver and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MU67">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003364.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="337" mass="37872" checksum="4553E5ED92EAB0BF" modified="2018-02-28" version="2">MATLSVIGSSSLIACAVFQNIQKSPEIRPLFYLSFCDLLLGLCWLTETLLYGASVANKDIICYNLQAVGQIFYISSFLYTINYIWYLYTELRMKHTQSGQSTSPLVIDYTCRVGQMAFVFSSLIPLLLMTPVFCLGNTSECFQNFSQSHKCILMHSPPSAVAELPPSANTSVCSTLYFYGITIFLGSFVLSLLTIMVLLIRAQTLYKKFVKSSGFLGSEQWAVIHIVDQRVRLYPMAFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPTSTSTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MW03</accession>
    <name>A0A096MW03_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Unconventional myosin-Ia</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Brush border myosin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Myosin I heavy chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MYO1A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in directing the movement of organelles along actin filaments.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906680.1">
        <property type="nucleotide sequence ID" value="XM_003906631.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017801451.1">
        <property type="nucleotide sequence ID" value="XM_017945962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MW03"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004044"/>
    <dbReference type="Ensembl" id="ENSPANT00000011292.3">
        <property type="protein sequence ID" value="ENSPANP00000004044.1"/>
        <property type="gene ID" value="ENSPANG00000004850.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022254"/>
    <dbReference type="KEGG" id="panu:101022254"/>
    <dbReference type="CTD" id="4640"/>
    <dbReference type="eggNOG" id="KOG0164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160660"/>
    <dbReference type="HOGENOM" id="CLU_000192_7_7_1"/>
    <dbReference type="OMA" id="IKPNEYQ"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004850">
        <property type="expression patterns" value="Expressed in ileum and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Unconventional myosin ID"/>
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        <property type="entry name" value="unconventional myosin-Ia isoform X1"/>
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        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IA"/>
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        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="entry name" value="MYSc"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 14" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="8"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="16">
        <location>
            <begin position="858"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="14">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1043" mass="118274" checksum="FD7411E29AF731FE" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX16</accession>
    <name>A0A096MX16_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DDX51</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.</text>
    </comment>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A096MX16"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004426"/>
    <dbReference type="Ensembl" id="ENSPANT00000023701.4">
        <property type="protein sequence ID" value="ENSPANP00000004426.2"/>
        <property type="gene ID" value="ENSPANG00000008107.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075141"/>
    <dbReference type="HOGENOM" id="CLU_003041_15_3_1"/>
    <dbReference type="OMA" id="HEVKAFD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008107">
        <property type="expression patterns" value="Expressed in aorta and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001539">
        <property type="entry name" value="ATP-dependent RNA helicase DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002026">
        <property type="entry name" value="DEAD-box helicase 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="235"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="486"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="48"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="11">
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            <begin position="65"/>
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        <location>
            <begin position="97"/>
            <end position="108"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056648"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004426.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="658" mass="71673" checksum="C3CAFD7AC17327C4" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX68</accession>
    <name>A0A096MX68_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-CpG binding domain protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MBD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSPANG00000021858.4"/>
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    <dbReference type="ExpressionAtlas" id="A0A096MX68">
        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:NuRD complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:chromatin binding"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <source>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004479.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="406" mass="42217" checksum="A1C527DD835A1092" modified="2022-05-25" version="2">MLARVPRAPRCGRGGSPGFQGLGYGRSAAPAGEGADAPGEAASCPEQEEGESAAGGSGAGGDSAIEQGGQGKAPGRWPWPGGGAGGLGAASVAVAGAGAVAGDGDGAGWLRLSPRGGSNGGDGGGSGGGSGGGEPGDPGPREEWEGDGLSAPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZ69</accession>
    <name>A0A096MZ69_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC24</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003909560.2">
        <property type="nucleotide sequence ID" value="XM_003909511.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZ69"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005264"/>
    <dbReference type="Ensembl" id="ENSPANT00000021197.3">
        <property type="protein sequence ID" value="ENSPANP00000005264.2"/>
        <property type="gene ID" value="ENSPANG00000000274.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026262"/>
    <dbReference type="KEGG" id="panu:101026262"/>
    <dbReference type="CTD" id="254359"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162361"/>
    <dbReference type="HOGENOM" id="CLU_027721_5_2_1"/>
    <dbReference type="OMA" id="RMHLTWL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000274">
        <property type="expression patterns" value="Expressed in amygdala and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZ69">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF414">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005264.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="284" mass="30317" checksum="FFA4CABCE64080CE" modified="2022-05-25" version="2">MGQPWAAGSADWAPARLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHISVLLGPALSALLRAHTPLHMAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHSYDLGPCHNLQAALGPRWALVWLWPFLASPLPGDGITFQTTADVGHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0H1</accession>
    <name>A0A096N0H1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leiomodin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cardiac leiomodin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Leiomodin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LMOD2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation. Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus). May also interact with TPM2 (via N-terminus). Interacts with FLII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Myofibril</location>
            <location evidence="7">Sarcomere</location>
            <location evidence="7">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomodulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896576.2">
        <property type="nucleotide sequence ID" value="XM_003896527.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0H1"/>
    <dbReference type="SMR" id="A0A096N0H1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005756"/>
    <dbReference type="Ensembl" id="ENSPANT00000008944.3">
        <property type="protein sequence ID" value="ENSPANP00000005756.2"/>
        <property type="gene ID" value="ENSPANG00000000492.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001041"/>
    <dbReference type="KEGG" id="panu:101001041"/>
    <dbReference type="CTD" id="442721"/>
    <dbReference type="eggNOG" id="KOG3735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156567"/>
    <dbReference type="HOGENOM" id="CLU_031052_4_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000492">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005865">
        <property type="term" value="C:striated muscle thin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000132">
        <property type="entry name" value="Leiomodin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF12">
        <property type="entry name" value="LEIOMODIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="14">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005756.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="547" mass="61732" checksum="94BB65180D7CA34A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0L8</accession>
    <name>A0A096N0L8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OTU domain-containing protein 3</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A096N0L8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005805"/>
    <dbReference type="Ensembl" id="ENSPANT00000027196.3">
        <property type="protein sequence ID" value="ENSPANP00000005805.1"/>
        <property type="gene ID" value="ENSPANG00000000487.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000066659.1">
        <property type="protein sequence ID" value="ENSPANP00000047899.1"/>
        <property type="gene ID" value="ENSPANG00000046891.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016392"/>
    <dbReference type="HOGENOM" id="CLU_056188_0_0_1"/>
    <dbReference type="OMA" id="MLCKNDS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000487">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990167">
        <property type="term" value="P:protein K27-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044313">
        <property type="term" value="P:protein K6-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22770">
        <property type="entry name" value="OTU_OTUD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000005">
        <property type="entry name" value="OTU domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="15">
        <location>
            <begin position="139"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="379"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="419"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005805.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="472" mass="52726" checksum="AC6EAC337E84B449" modified="2014-11-26" version="1">MGVPLALYGVCSPSPAKEAGIPSCDRGAGRRRRRGCCVVVAGLRCPRCFAFLTLEAAAGGSCGFPFCRWGLQAKAMSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDKSSVRELHIAYRYGEHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGMDSEDDLRDEVEDAVQKVCNATGCSDFNLIVQNLEAENYNIESAIIAMLQMNQGKINNAEENLEPTGRVLKQCGPLWEEGGSGARIFGNQGLNEGSTENNKARASPSEENKANKNQLAKVTNKQRREQQRLEKKKRQEERHRHKALESRGSHRDNNRSEAEANTQVTLVKTFAALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N317</accession>
    <name>A0A096N317_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N317"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006715"/>
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        <property type="protein sequence ID" value="ENSPANP00000006715.3"/>
        <property type="gene ID" value="ENSPANG00000005380.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000067969.1">
        <property type="protein sequence ID" value="ENSPANP00000060941.1"/>
        <property type="gene ID" value="ENSPANG00000005380.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000072476.1">
        <property type="protein sequence ID" value="ENSPANP00000059265.1"/>
        <property type="gene ID" value="ENSPANG00000005380.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000082721.1">
        <property type="protein sequence ID" value="ENSPANP00000061224.1"/>
        <property type="gene ID" value="ENSPANG00000005380.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156221"/>
    <dbReference type="HOGENOM" id="CLU_027185_2_0_1"/>
    <dbReference type="OMA" id="QNRGPMA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005380">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042382">
        <property type="term" value="C:paraspeckles"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12948">
        <property type="entry name" value="NOPS_PSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12587">
        <property type="entry name" value="RRM1_PSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12590">
        <property type="entry name" value="RRM2_PSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000043">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000126">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NOPS"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR034526">
        <property type="entry name" value="PSF_NOPS"/>
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        <property type="entry name" value="PSF_RRM1"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
        <property type="entry name" value="NOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="297"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="371"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1"/>
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            <begin position="579"/>
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        <location>
            <begin position="9"/>
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    </feature>
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        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
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            <begin position="133"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
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            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="641"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="668"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006715.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="707" mass="76107" checksum="6D8D5EA95A8DE8F7" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5U1</accession>
    <name>A0A096N5U1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 19 open reading frame 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C19orf33</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096N5U1"/>
    <dbReference type="Ensembl" id="ENSPANT00000027733.3">
        <property type="protein sequence ID" value="ENSPANP00000007807.1"/>
        <property type="gene ID" value="ENSPANG00000010968.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101021023"/>
    <dbReference type="eggNOG" id="ENOG502TD4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163639"/>
    <dbReference type="HOGENOM" id="CLU_177127_0_0_1"/>
    <dbReference type="OMA" id="GKKEAPH"/>
    <dbReference type="OrthoDB" id="9485859at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010968">
        <property type="expression patterns" value="Expressed in aorta and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026621">
        <property type="entry name" value="IMUP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15761">
        <property type="entry name" value="IMUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="102" mass="10571" checksum="937E95952C1553D9" modified="2014-11-26" version="1">MEFDLGAALEPTSQEPGVEAGHGGDPKLSPHKLQGRSEAGAGPGPEQGHHSSSDSSSSSSDSDTDVKPHTAGSKQHESTPGKAKKPKVKKKKKEKGKKEAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7X5</accession>
    <name>A0A096N7X5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Adenylate kinase isoenzyme 5</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
            <ecNumber evidence="7">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-AMP transphosphorylase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AK5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 20">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. Interacts with YWHAZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EC" id="2.7.4.6" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003892142.1">
        <property type="nucleotide sequence ID" value="XM_003892093.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N7X5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008691"/>
    <dbReference type="Ensembl" id="ENSPANT00000010180.3">
        <property type="protein sequence ID" value="ENSPANP00000008691.1"/>
        <property type="gene ID" value="ENSPANG00000017674.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011586"/>
    <dbReference type="KEGG" id="panu:101011586"/>
    <dbReference type="CTD" id="26289"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155917"/>
    <dbReference type="HOGENOM" id="CLU_034712_1_0_1"/>
    <dbReference type="OMA" id="ETHIVHQ"/>
    <dbReference type="OrthoDB" id="6436361at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017674">
        <property type="expression patterns" value="Expressed in Ammon's horn and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22978">
        <property type="entry name" value="DD_AK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000583">
        <property type="entry name" value="Adenylate kinase isoenzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001176">
        <property type="entry name" value="Adenylate kinase isoenzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006267">
        <property type="entry name" value="AK1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01360">
        <property type="entry name" value="aden_kin_iso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="562" mass="63361" checksum="5DFF091405690A7D" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8S5</accession>
    <name>A0A096N8S5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC24</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009205235.2">
        <property type="nucleotide sequence ID" value="XM_009206971.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8S5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009006"/>
    <dbReference type="Ensembl" id="ENSPANT00000006203.3">
        <property type="protein sequence ID" value="ENSPANP00000009006.2"/>
        <property type="gene ID" value="ENSPANG00000006221.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012763"/>
    <dbReference type="CTD" id="149473"/>
    <dbReference type="eggNOG" id="ENOG502S6CH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011926"/>
    <dbReference type="HOGENOM" id="CLU_993818_0_0_1"/>
    <dbReference type="OMA" id="LASTCRW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006221">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031367">
        <property type="entry name" value="CCDC24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28601">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28601:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15669">
        <property type="entry name" value="CCDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009006.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="307" mass="34388" checksum="F09BE454CFD4D2A5" modified="2022-05-25" version="2">MLRHSPSLWELVEEHIPLRERPEVKRILGEAAVDLSLELRAEVAMLRALLQEARSSQAPSSRPISDPSSLLAPPPLLKDLLRQELRQLLQGLHHKAICEGRDQAQAWVQYSPRVLHFALEEPRCDLPEQEIFQMRGGRPSSGHRDLSIIKDQLNVSNIDQVARHLRGLLEEECHTLEREIPILQRCLEEEYMRPCHPSEAALEPTLAELKEQKKAMEQELQASVGPSCVSPNHRQWPLGSSTQGLRPLLPLCGVAPLQCCLPAPPLEPCLRPRGQAATRRWGRQLQYSPREGSASTPMSSAASQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9R4</accession>
    <name>A0A096N9R4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stalled ribosome sensor GCN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GCN1 eIF-2-alpha kinase activator homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">GCN1-like protein 1</fullName>
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        <alternativeName>
            <fullName evidence="14">General control of amino-acid synthesis 1-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">Translational activator GCN1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GCN1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity. Interacts with RNF14; interaction takes place following ribosome stalling and promotes recruitment of RNF14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031506673.1">
        <property type="nucleotide sequence ID" value="XM_031650813.1"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000009395"/>
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        <property type="protein sequence ID" value="ENSPANP00000009395.3"/>
        <property type="gene ID" value="ENSPANG00000008132.3"/>
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    <dbReference type="GeneID" id="101007244"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000153612"/>
    <dbReference type="HOGENOM" id="CLU_000504_2_2_1"/>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="Bgee" id="ENSPANG00000008132">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N9R4">
        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
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    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055106">
        <property type="term" value="F:ubiquitin-protein transferase regulator activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0160127">
        <property type="term" value="P:protein-RNA covalent cross-linking repair"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.10.10:FF:000162">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000198">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000226">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000361">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
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    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
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    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="TOG" evidence="20">
        <location>
            <begin position="1365"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="18">
        <location>
            <begin position="1616"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="18">
        <location>
            <begin position="1658"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="18">
        <location>
            <begin position="2006"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="817"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009395.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2671" mass="292718" checksum="23C6B7BC2B16639F" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9S7</accession>
    <name>A0A096N9S7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine receptor 1E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HTR1E</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021793270.1">
        <property type="nucleotide sequence ID" value="XM_021937578.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N9S7"/>
    <dbReference type="SMR" id="A0A096N9S7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009410"/>
    <dbReference type="Ensembl" id="ENSPANT00000019310.3">
        <property type="protein sequence ID" value="ENSPANP00000009410.1"/>
        <property type="gene ID" value="ENSPANG00000005474.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022549"/>
    <dbReference type="KEGG" id="panu:101022549"/>
    <dbReference type="CTD" id="3354"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222287"/>
    <dbReference type="HOGENOM" id="CLU_009579_11_1_1"/>
    <dbReference type="OMA" id="IHTSIRI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005474">
        <property type="expression patterns" value="Expressed in pancreas and 32 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001586">
        <property type="term" value="F:Gi/o-coupled serotonin receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0099589">
        <property type="term" value="F:serotonin receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007198">
        <property type="term" value="P:adenylate cyclase-inhibiting serotonin receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15335">
        <property type="entry name" value="7tmA_5-HT1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000085">
        <property type="entry name" value="5-hydroxytryptamine receptor 1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002231">
        <property type="entry name" value="5HT_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF191">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01101">
        <property type="entry name" value="5HTRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="365" mass="41681" checksum="BC3C602C1A6E1228" modified="2014-11-26" version="1">MNITNCTTEAGMAVRPKTITEKMLICMTLVVITTLTTLLNLAVIMAICTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFANCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NC77</accession>
    <name>A0A096NC77_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Xaa-Pro aminopeptidase 2</fullName>
            <ecNumber evidence="6">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Membrane-bound aminopeptidase P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">XPNPEP2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="6"/>
    <dbReference type="RefSeq" id="XP_003918307.1">
        <property type="nucleotide sequence ID" value="XM_003918258.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NC77"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010417"/>
    <dbReference type="MEROPS" id="M24.005"/>
    <dbReference type="Ensembl" id="ENSPANT00000022825.3">
        <property type="protein sequence ID" value="ENSPANP00000010417.1"/>
        <property type="gene ID" value="ENSPANG00000008086.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002120"/>
    <dbReference type="KEGG" id="panu:101002120"/>
    <dbReference type="CTD" id="7512"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157196"/>
    <dbReference type="HOGENOM" id="CLU_011781_2_2_1"/>
    <dbReference type="OMA" id="LTHFRYT"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008086">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NC77">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000008">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922561" description="Xaa-Pro aminopeptidase 2" evidence="22">
        <location>
            <begin position="22"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Creatinase N-terminal" evidence="24">
        <location>
            <begin position="55"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="23">
        <location>
            <begin position="365"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="25">
        <location>
            <begin position="585"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="674" mass="75486" checksum="6D959BBBA9CDA613" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCC8</accession>
    <name>A0A096NCC8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">N-myc and STAT interactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NMI</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NMI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021779283.1">
        <property type="nucleotide sequence ID" value="XM_021923591.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NCC8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010470"/>
    <dbReference type="Ensembl" id="ENSPANT00000026131.3">
        <property type="protein sequence ID" value="ENSPANP00000010470.2"/>
        <property type="gene ID" value="ENSPANG00000006057.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019452"/>
    <dbReference type="KEGG" id="panu:101019452"/>
    <dbReference type="CTD" id="9111"/>
    <dbReference type="eggNOG" id="ENOG502QVH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063686"/>
    <dbReference type="HOGENOM" id="CLU_047262_0_0_1"/>
    <dbReference type="OMA" id="IYAQIPE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006057">
        <property type="expression patterns" value="Expressed in perirenal fat and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032687">
        <property type="term" value="P:negative regulation of interferon-alpha production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032688">
        <property type="term" value="P:negative regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901223">
        <property type="term" value="P:negative regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902524">
        <property type="term" value="P:positive regulation of protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12544">
        <property type="entry name" value="RRM_NMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000300">
        <property type="entry name" value="Interferon-induced protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009909">
        <property type="entry name" value="Nmi/IFP35_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009938">
        <property type="entry name" value="Nmi/IFP35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225:SF4">
        <property type="entry name" value="N-MYC-INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07334">
        <property type="entry name" value="IFP_35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07292">
        <property type="entry name" value="NID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Nmi/IFP 35" evidence="12">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="NID" evidence="11">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="NID" evidence="11">
        <location>
            <begin position="203"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010470.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="307" mass="35127" checksum="F1AAD85E6577DA8D" modified="2018-02-28" version="2">MEADKDNTQQVLKEHGPHEFIKDEQNKELTDEMTKKNIQLKEEIQKLETELQEATREFQIKEDIPETKMKLLSVETPENDSQLSNISCSFQVSSKVPYELQKGQALITFEKEEVAQNVVSMSKHQVRIKDVNLEVTAKPVPLNSGVRFQVYIEVSKMKINVTEIPDTLPEDQMRDKLELSFCKSRNGGGEVDHVDYDRQSGSAVITFVETGVADKILKKKEYPLYINETCHRVTVSPYTEIHLRKYQIFSGTSKRTVLLTGMEGIQMDEESVEDLINIHFQRAKNGGGEVDVVKCSLDQPHIAYFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NG17</accession>
    <name>A0A096NG17_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">L3MBTL histone methyl-lysine binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">L3MBTL4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021785653.2">
        <property type="nucleotide sequence ID" value="XM_021929961.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031514574.1">
        <property type="nucleotide sequence ID" value="XM_031658714.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031514576.1">
        <property type="nucleotide sequence ID" value="XM_031658716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NG17"/>
    <dbReference type="Ensembl" id="ENSPANT00000023972.3">
        <property type="protein sequence ID" value="ENSPANP00000011876.3"/>
        <property type="gene ID" value="ENSPANG00000008894.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006742"/>
    <dbReference type="KEGG" id="panu:101006742"/>
    <dbReference type="CTD" id="91133"/>
    <dbReference type="eggNOG" id="KOG3766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158264"/>
    <dbReference type="HOGENOM" id="CLU_004064_3_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008894">
        <property type="expression patterns" value="Expressed in thyroid gland and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NG17">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20136">
        <property type="entry name" value="MBT_L3MBTL4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20139">
        <property type="entry name" value="MBT_L3MBTL4_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09582">
        <property type="entry name" value="SAM_Scm-like-3MBT3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000007">
        <property type="entry name" value="Lethal(3)malignant brain tumor-like protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF78">
        <property type="entry name" value="LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="52"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="160"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="269"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="534"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011876.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="614" mass="70028" checksum="D313360E8A2F6143" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLK5</accession>
    <name>A0A096NLK5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger and SCAN domain-containing protein 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Zinc finger protein 187</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZSCAN26</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NLK5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013863"/>
    <dbReference type="Ensembl" id="ENSPANT00000012297.3">
        <property type="protein sequence ID" value="ENSPANP00000013863.3"/>
        <property type="gene ID" value="ENSPANG00000026502.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162298"/>
    <dbReference type="HOGENOM" id="CLU_002678_49_2_1"/>
    <dbReference type="OMA" id="IKHEGSH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026502">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLK5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001991">
        <property type="entry name" value="Zinc finger and SCAN domain containing 26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000056">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000467">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001661">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001087">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002516">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001693">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 26 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="19">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013863.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="477" mass="54686" checksum="EFA717382A9A4854" modified="2022-05-25" version="3">MATALVSAHSLAPLNLKKEGLRVVREDHYSTWEQGFKLQGNSKGLGQEPLCKQFRQLRYEETTGPREALSRLRELCQQWLQPATHTKEQILELLVLEQFLTILPKELQAWVEHHPESGEDMVVALEDLQLDLGETGQQVDPDQAKEQKILVEEMAPLRGVQEQQVRPECEVTKPEKEKGEETRIENGKLVVVTDSCGRVESSGKISEPMEAHNEGSNLERQQAKPKEETEYKCSECGQGFLQHSDLIEHASTHTGKKLCESDVCQSSSLTGHKVLSREKGHQCRECGKAFQRSSHLVRHQKIHLGEKPYQCNECGKVFSQNAGLLEHLRIHTGEKPYLCIHCGKNFRRSSHLNRHQRIHSQEEPCECKECGKTFSQALLLTHHQRIHSHSKNHQCNECGKAFSLTSDLIRHHRIHTGEKPFKCNICQKAFRLNSHLAQHVRIHNEEKPYQCSECGEAFRQRSGLFQHQRYHHKDKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLY7</accession>
    <name>A0A096NLY7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase TRIM69</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING finger protein 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase TRIM69</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Tripartite motif-containing protein 69</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">TRIM69</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homo-multimer; required for antiviral activity. Interacts with PML.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_009208335.2">
        <property type="nucleotide sequence ID" value="XM_009210071.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLY7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013996"/>
    <dbReference type="Ensembl" id="ENSPANT00000026686.3">
        <property type="protein sequence ID" value="ENSPANP00000013996.3"/>
        <property type="gene ID" value="ENSPANG00000017923.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999332"/>
    <dbReference type="KEGG" id="panu:100999332"/>
    <dbReference type="CTD" id="140691"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160707"/>
    <dbReference type="HOGENOM" id="CLU_013137_0_3_1"/>
    <dbReference type="OMA" id="TEELTIH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017923">
        <property type="expression patterns" value="Expressed in testis and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLY7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16611">
        <property type="entry name" value="RING-HC_TRIM69_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15818">
        <property type="entry name" value="SPRY_PRY_TRIM69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000058">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002162">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000583">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="15 25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="26">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="27">
        <location>
            <begin position="305"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00076766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013996.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="500" mass="57298" checksum="0D3331449E63584B" modified="2022-05-25" version="3">MEVSSNPSSNIDPGNYVEMNDSIAHLPSKVVIQDITMELHCPLCNDWFHDPLMLSCGHNFCQACIQDFWRLQAKETFCPDCKMLCQYSNCTFNLVLDKLVEKIKKLPLLKGHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQSLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQEKTEQQNSFDFLKDITTLLDSLEQGMRVLATRELISRKLNPGQYKGPIQYMVWREMQNTLCPGLSPLTLDPKTAHPNLVLSKNQTSVWHGDIKKVMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSCSLTLTNNLNKVGIYLDYEGGQVSFYNAKTMTHIYTFSNTFIEKLYPYFCPCLNDGGENKEPLHILHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPT1</accession>
    <name>A0A096NPT1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 167 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM167A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM167 (SEC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NPT1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015013"/>
    <dbReference type="Ensembl" id="ENSPANT00000006980.3">
        <property type="protein sequence ID" value="ENSPANP00000015013.2"/>
        <property type="gene ID" value="ENSPANG00000008480.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RY4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159097"/>
    <dbReference type="HOGENOM" id="CLU_111170_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008480">
        <property type="expression patterns" value="Expressed in pineal body and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NPT1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024280">
        <property type="entry name" value="FAM167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051771">
        <property type="entry name" value="FAM167_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32289">
        <property type="entry name" value="PROTEIN FAM167A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32289:SF3">
        <property type="entry name" value="PROTEIN FAM167A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11652">
        <property type="entry name" value="FAM167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015013.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="214" mass="24232" checksum="D570D7A26461E109" modified="2022-05-25" version="2">MSVPQIHVEEVGAQEEAGAAAPPDDHLRSLKALTEKLRLETRRPSYLEWQARLEEQTWPFPRPAAEPQASLEEGEHGGQEPLLPLREPGQHAPPARSASRGTTPLSTGKLEGFQSIDEAIAWLRKELTEMRLQDQQLARQLMRLRSDINKLKIEHTCRLHRRMLNDATYELEERDELADLFCDSPLASSFSLSTPLKLIGVTKMNINSRRSLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQR8</accession>
    <name>A0A096NQR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DDX54</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAD box protein 54</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DDX54</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts in a hormone-dependent manner with nuclear receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_009180028.2">
        <property type="nucleotide sequence ID" value="XM_009181764.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQR8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015382"/>
    <dbReference type="Ensembl" id="ENSPANT00000000375.3">
        <property type="protein sequence ID" value="ENSPANP00000015382.3"/>
        <property type="gene ID" value="ENSPANG00000008883.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011701"/>
    <dbReference type="CTD" id="79039"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075100"/>
    <dbReference type="HOGENOM" id="CLU_003041_5_2_1"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008883">
        <property type="expression patterns" value="Expressed in cornea and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000784">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="127"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="326"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="605"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="726"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015382.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="884" mass="98915" checksum="991E00906B0236F4" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NS96</accession>
    <name>A0A096NS96_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Activator of 90 kDa heat shock protein ATPase homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">AHSA1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902159.1">
        <property type="nucleotide sequence ID" value="XM_003902110.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NS96"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015916"/>
    <dbReference type="Ensembl" id="ENSPANT00000007431.3">
        <property type="protein sequence ID" value="ENSPANP00000015916.1"/>
        <property type="gene ID" value="ENSPANG00000026009.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009440"/>
    <dbReference type="KEGG" id="panu:101009440"/>
    <dbReference type="CTD" id="10598"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155144"/>
    <dbReference type="HOGENOM" id="CLU_049046_0_0_1"/>
    <dbReference type="OMA" id="HIAMKWR"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026009">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NS96">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036506">
        <property type="term" value="P:maintenance of unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.20:FF:000001">
        <property type="entry name" value="Activator of 90 kDa heat shock protein ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000018">
        <property type="entry name" value="Activator of 90 kDa heat shock protein ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF7">
        <property type="entry name" value="ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="38199" checksum="6A744A719C6D6E0F" modified="2014-11-26" version="1">MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTVNGESVDPVGQPALKTEELKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSK3</accession>
    <name>A0A096NSK3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein O-glucosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POGLUT1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894014.1">
        <property type="nucleotide sequence ID" value="XM_003893965.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NSK3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016024"/>
    <dbReference type="Ensembl" id="ENSPANT00000024602.3">
        <property type="protein sequence ID" value="ENSPANP00000016024.1"/>
        <property type="gene ID" value="ENSPANG00000020852.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020502"/>
    <dbReference type="KEGG" id="panu:101020502"/>
    <dbReference type="CTD" id="56983"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158283"/>
    <dbReference type="HOGENOM" id="CLU_041919_1_0_1"/>
    <dbReference type="OMA" id="EDDCMFP"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020852">
        <property type="expression patterns" value="Expressed in axillary lymph node and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048318">
        <property type="term" value="P:axial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048339">
        <property type="term" value="P:paraxial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010470">
        <property type="term" value="P:regulation of gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922188" evidence="4">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="121"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="392" mass="46211" checksum="6D14ED7C7C67BF5B" modified="2014-11-26" version="1">MEWWASSPLRLWLLLFLLPPAQGRQKESGSKWKVFIDQINRSLENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQIIKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKMLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NT20</accession>
    <name>A0A096NT20_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUBGCP5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031524750.1">
        <property type="nucleotide sequence ID" value="XM_031668890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NT20"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016191"/>
    <dbReference type="Ensembl" id="ENSPANT00000025401.3">
        <property type="protein sequence ID" value="ENSPANP00000016191.3"/>
        <property type="gene ID" value="ENSPANG00000020044.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025159"/>
    <dbReference type="CTD" id="114791"/>
    <dbReference type="eggNOG" id="KOG4344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155962"/>
    <dbReference type="HOGENOM" id="CLU_011574_0_0_1"/>
    <dbReference type="OMA" id="RTNQFEV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020044">
        <property type="expression patterns" value="Expressed in axillary lymph node and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000005">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="11">
        <location>
            <begin position="271"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="10">
        <location>
            <begin position="716"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016191.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118270" checksum="D6FB71B0715873C6" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYC6</accession>
    <name>A0A096NYC6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">ZFP90 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZFP90</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021787783.2">
        <property type="nucleotide sequence ID" value="XM_021932091.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021787784.2">
        <property type="nucleotide sequence ID" value="XM_021932092.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021787785.2">
        <property type="nucleotide sequence ID" value="XM_021932093.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021787786.2">
        <property type="nucleotide sequence ID" value="XM_021932094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYC6"/>
    <dbReference type="Ensembl" id="ENSPANT00000001477.3">
        <property type="protein sequence ID" value="ENSPANP00000018088.3"/>
        <property type="gene ID" value="ENSPANG00000024395.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004907"/>
    <dbReference type="CTD" id="146198"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162132"/>
    <dbReference type="HOGENOM" id="CLU_002678_0_12_1"/>
    <dbReference type="OMA" id="TLEDTWD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024395">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NYC6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000338">
        <property type="entry name" value="zinc finger protein 383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000485">
        <property type="entry name" value="Zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000568">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000934">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001698">
        <property type="entry name" value="Zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF75">
        <property type="entry name" value="ZFP14 ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="18">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018088.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="636" mass="72904" checksum="1A2A88D2214E3AED" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2Z2</accession>
    <name>A0A096P2Z2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Peripheral myelin protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PMP22</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Might be involved in growth regulation, and in myelinization in the peripheral nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021784437.1">
        <property type="nucleotide sequence ID" value="XM_021928745.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021784438.1">
        <property type="nucleotide sequence ID" value="XM_021928746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2Z2"/>
    <dbReference type="SMR" id="A0A096P2Z2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019717"/>
    <dbReference type="Ensembl" id="ENSPANT00000022673.3">
        <property type="protein sequence ID" value="ENSPANP00000019717.2"/>
        <property type="gene ID" value="ENSPANG00000023722.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021463"/>
    <dbReference type="KEGG" id="panu:101021463"/>
    <dbReference type="CTD" id="5376"/>
    <dbReference type="eggNOG" id="ENOG502S0F5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182696"/>
    <dbReference type="HOGENOM" id="CLU_138632_1_0_1"/>
    <dbReference type="OMA" id="HTADLWQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023722">
        <property type="expression patterns" value="Expressed in zone of skin and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P2Z2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000019">
        <property type="entry name" value="Peripheral myelin protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003936">
        <property type="entry name" value="PMP22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004032">
        <property type="entry name" value="PMP22_EMP_MP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF7">
        <property type="entry name" value="PERIPHERAL MYELIN PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01453">
        <property type="entry name" value="EPMEMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01458">
        <property type="entry name" value="PMYELIN22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01221">
        <property type="entry name" value="PMP22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01222">
        <property type="entry name" value="PMP22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019717.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="160" mass="17847" checksum="EDE8E307453809F2" modified="2018-02-28" version="2">MLLLLLGIIVLHVAVLVLLFVSTIVSQWIVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P332</accession>
    <name>A0A096P332_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein flightless-1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FLII</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003912473.1">
        <property type="nucleotide sequence ID" value="XM_003912424.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P332"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019757"/>
    <dbReference type="Ensembl" id="ENSPANT00000022357.3">
        <property type="protein sequence ID" value="ENSPANP00000019757.1"/>
        <property type="gene ID" value="ENSPANG00000023684.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019011"/>
    <dbReference type="KEGG" id="panu:101019011"/>
    <dbReference type="CTD" id="2314"/>
    <dbReference type="eggNOG" id="KOG0444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156643"/>
    <dbReference type="HOGENOM" id="CLU_002568_1_0_1"/>
    <dbReference type="OMA" id="CFHGWSA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023684">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P332">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11280">
        <property type="entry name" value="gelsolin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000033">
        <property type="entry name" value="FLII, actin remodeling protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000050">
        <property type="entry name" value="FLII, actin remodeling protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000054">
        <property type="entry name" value="FLII, actin remodeling protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000019">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000020">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000030">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000031">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000034">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000021">
        <property type="entry name" value="protein flightless-1 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="18">
        <location>
            <begin position="241"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="509"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="629"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="758"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="1076"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="1182"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="414"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="951"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1270" mass="144839" checksum="CC995455194E4C91" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5B8</accession>
    <name>A0A096P5B8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase 12</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell division protein kinase 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CDK12</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">(Microbial infection) Interacts with human herpes virus 1 (HHV-1) transcriptional regulator ICP22.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003912979.1">
        <property type="nucleotide sequence ID" value="XM_003912930.5"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000020543"/>
    <dbReference type="Ensembl" id="ENSPANT00000004680.3">
        <property type="protein sequence ID" value="ENSPANP00000020543.2"/>
        <property type="gene ID" value="ENSPANG00000021895.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101006156"/>
    <dbReference type="CTD" id="51755"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157595"/>
    <dbReference type="OMA" id="HWGAPAQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021895">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002944">
        <property type="term" value="C:cyclin K-CDK12 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071391">
        <property type="term" value="P:cellular response to estrogen stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033147">
        <property type="term" value="P:negative regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000737">
        <property type="term" value="P:negative regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07864">
        <property type="entry name" value="STKc_CDK12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000102">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000074">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF126">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="727"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="476"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1047"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1160"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1220"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1441"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="479"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1268"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1473"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020543.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1490" mass="164108" checksum="003143605DFFDD5C" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5Z5</accession>
    <name>A0A096P5Z5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucose-6-phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">G6PC3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glucose-6-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.9" evidence="11"/>
    <dbReference type="RefSeq" id="XP_003913204.1">
        <property type="nucleotide sequence ID" value="XM_003913155.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P5Z5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020770"/>
    <dbReference type="Ensembl" id="ENSPANT00000013764.3">
        <property type="protein sequence ID" value="ENSPANP00000020770.1"/>
        <property type="gene ID" value="ENSPANG00000021316.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003602"/>
    <dbReference type="KEGG" id="panu:101003602"/>
    <dbReference type="CTD" id="92579"/>
    <dbReference type="eggNOG" id="ENOG502QS5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183150"/>
    <dbReference type="HOGENOM" id="CLU_052517_0_0_1"/>
    <dbReference type="OMA" id="KKWCSRA"/>
    <dbReference type="OrthoDB" id="6416209at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021316">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004346">
        <property type="term" value="F:glucose-6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015760">
        <property type="term" value="P:glucose-6-phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03381">
        <property type="entry name" value="PAP2_glucose_6_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000018">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016275">
        <property type="entry name" value="Glucose-6-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591:SF2">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000905">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="15">
        <location>
            <begin position="53"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="346" mass="38749" checksum="72327F0D9D42C7C0" modified="2014-11-26" version="1">MESTLGVGIVIAEALQNQLAWLENVWLWVTFLGDPKILFLFYFPAAYYASRRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQAPAQVHQFPSSCETGPGSPSGHCMITGAALWPIMTALSSQVATRARSRWVRVMPSLAYCTFLLAVGLSRIFILAHFPHQVLAGLITGAVLGWLMTPRVPVERELSFYGLTALALMLGTSLIYWTLFTLGLDLSWSISLAFKWCERPEWIHMDSRPFASLSRDSGAALGLGIALHSPCYAQVRRAQLGNGQKIACLVLAMGLLGPLDWLGHPPQISLFYIFNFLKYTLWPCLVLALVPWAVHMFSAQEAPPIHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P6D9</accession>
    <name>A0A096P6D9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translational activator of cytochrome c oxidase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TACO1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P6D9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020914"/>
    <dbReference type="Ensembl" id="ENSPANT00000022501.3">
        <property type="protein sequence ID" value="ENSPANP00000020914.1"/>
        <property type="gene ID" value="ENSPANG00000021017.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101021713"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012820"/>
    <dbReference type="HOGENOM" id="CLU_062974_3_0_1"/>
    <dbReference type="OMA" id="NFDIPDE"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021017">
        <property type="expression patterns" value="Expressed in metanephros cortex and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061743">
        <property type="term" value="P:motor learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070129">
        <property type="term" value="P:regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.980:FF:000008">
        <property type="entry name" value="Translational activator of cytochrome c oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="12">
        <location>
            <begin position="61"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="11">
        <location>
            <begin position="137"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="297" mass="32174" checksum="E4AF82B110CC0105" modified="2014-11-26" version="1">MAAWAAASLSRAAARCLLARGPGVGAASPRDPRPSHSEPRGCGAAPGRTLHLTAAVPAGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKSTIEAALKMEKTKDVYLLYACRGPGGSSLLIEALSNSGHKCQSDIRHILNKNGGVMAEGARHSFDKKGVIVVGVEDREKKAVNLERALELAIEAGAEDVKETEDEEERNVFKFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALGNHEDVIHVYDNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUH9</accession>
    <name>A0A0A0MUH9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleus accumbens associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NACC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_009191913.1">
        <property type="nucleotide sequence ID" value="XM_009193649.4"/>
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    <dbReference type="RefSeq" id="XP_009191914.1">
        <property type="nucleotide sequence ID" value="XM_009193650.4"/>
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    <dbReference type="RefSeq" id="XP_009191915.1">
        <property type="nucleotide sequence ID" value="XM_009193651.4"/>
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    <dbReference type="RefSeq" id="XP_009191916.1">
        <property type="nucleotide sequence ID" value="XM_009193652.3"/>
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    <dbReference type="RefSeq" id="XP_017807744.1">
        <property type="nucleotide sequence ID" value="XM_017952255.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A0A0MUH9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001549"/>
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        <property type="protein sequence ID" value="ENSPANP00000001549.1"/>
        <property type="gene ID" value="ENSPANG00000004447.3"/>
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    <dbReference type="GeneID" id="101011182"/>
    <dbReference type="KEGG" id="panu:101011182"/>
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        <property type="component" value="Chromosome 20"/>
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    <dbReference type="Bgee" id="ENSPANG00000004447">
        <property type="expression patterns" value="Expressed in amygdala and 61 other cell types or tissues"/>
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        <property type="term" value="C:cell junction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="BTB_POZ_BTBD14B_NAC1"/>
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    <dbReference type="FunFam" id="1.10.10.2590:FF:000002">
        <property type="entry name" value="Putative nucleus accumbens-associated protein 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.710.10:FF:000009">
        <property type="entry name" value="Zinc finger and BTB domain-containing 37"/>
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        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BEN_domain"/>
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    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
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    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF3">
        <property type="entry name" value="NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="30"/>
            <end position="94"/>
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    <feature type="domain" description="BEN" evidence="7">
        <location>
            <begin position="374"/>
            <end position="471"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="292"/>
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        <location>
            <begin position="141"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="251"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001549.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="527" mass="57348" checksum="1C20D4053D3C3CAA" modified="2015-01-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUU5</accession>
    <name>A0A0A0MUU5_PAPAN</name>
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        <recommendedName>
            <fullName evidence="13">Zinc finger protein 507</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF507</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUU5"/>
    <dbReference type="Ensembl" id="ENSPANT00000020607.3">
        <property type="protein sequence ID" value="ENSPANP00000003524.3"/>
        <property type="gene ID" value="ENSPANG00000010840.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043434"/>
    <dbReference type="OMA" id="KIGCEGR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010840">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MUU5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000719">
        <property type="entry name" value="Zinc finger protein 507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000884">
        <property type="entry name" value="Zinc finger protein 507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000964">
        <property type="entry name" value="zinc finger protein 507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF74">
        <property type="entry name" value="ZINC FINGER PROTEIN 507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="961"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="881"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003524.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111278" checksum="BE0AA2960A643683" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LE52</accession>
    <name>A0A2I3LE52_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type-II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the seminal plasma protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LE52"/>
    <dbReference type="Ensembl" id="ENSPANT00000053401.2">
        <property type="protein sequence ID" value="ENSPANP00000021719.1"/>
        <property type="gene ID" value="ENSPANG00000009363.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162766"/>
    <dbReference type="OMA" id="NNLTWCA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009363">
        <property type="expression patterns" value="Expressed in pituitary gland and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LE52">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000008">
        <property type="entry name" value="Epididymal sperm-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051666">
        <property type="entry name" value="SP_Capacitation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918:SF2">
        <property type="entry name" value="EPIDIDYMAL SPERM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918">
        <property type="entry name" value="SEMINAL PLASMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014144979" description="Fibronectin type-II domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="75" mass="8758" checksum="38B198DD279E60FD" modified="2018-02-28" version="1">MTRWSSYLLGWTTFLLCSYESSGGISALVPGFPCHFPFNYKNKNYFNCTNKGSKENLVWCATSYNYDQDHTWVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LFT0</accession>
    <name>A0A2I3LFT0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Basic helix-loop-helix ARNT like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BMAL2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LFT0"/>
    <dbReference type="Ensembl" id="ENSPANT00000032795.2">
        <property type="protein sequence ID" value="ENSPANP00000022307.2"/>
        <property type="gene ID" value="ENSPANG00000004474.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160423"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004474">
        <property type="expression patterns" value="Expressed in esophagus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LFT0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990513">
        <property type="term" value="C:CLOCK-BMAL transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042753">
        <property type="term" value="P:positive regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11469">
        <property type="entry name" value="bHLH-PAS_ARNTL2_PASD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000006">
        <property type="entry name" value="aryl hydrocarbon receptor nuclear translocator-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000018">
        <property type="entry name" value="Aryl hydrocarbon receptor nuclear translocator-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000010">
        <property type="entry name" value="Aryl hydrocarbon receptor nuclear translocator-like, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="344"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022307.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="602" mass="67541" checksum="520D32174C3A8DE1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LL01</accession>
    <name>A0A2I3LL01_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S3a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LL01"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024110"/>
    <dbReference type="Ensembl" id="ENSPANT00000049750.2">
        <property type="protein sequence ID" value="ENSPANP00000024110.1"/>
        <property type="gene ID" value="ENSPANG00000035057.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278357"/>
    <dbReference type="OMA" id="ATEMEIN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035057">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10629" checksum="6F84F1BE07A1697C" modified="2018-02-28" version="1">MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLITRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LN37</accession>
    <name>A0A2I3LN37_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a homohexamer that can probably bind six kinase subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892186.1">
        <property type="nucleotide sequence ID" value="XM_003892137.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003892793.1">
        <property type="nucleotide sequence ID" value="XM_003892744.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LN37"/>
    <dbReference type="SMR" id="A0A2I3LN37"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024847"/>
    <dbReference type="Ensembl" id="ENSPANT00000037433.2">
        <property type="protein sequence ID" value="ENSPANP00000024847.1"/>
        <property type="gene ID" value="ENSPANG00000033200.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101004031"/>
    <dbReference type="GeneID" id="101004599"/>
    <dbReference type="KEGG" id="panu:101004031"/>
    <dbReference type="KEGG" id="panu:101004599"/>
    <dbReference type="CTD" id="1163"/>
    <dbReference type="GeneTree" id="ENSGT00950000182971"/>
    <dbReference type="OMA" id="MSENEWR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033200">
        <property type="expression patterns" value="Expressed in thymus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="79" mass="9660" checksum="E64207B140FA38D5" modified="2018-02-28" version="1">MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRPLPKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LNT0</accession>
    <name>A0A2I3LNT0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lck interacting transmembrane adaptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LIME1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LNT0"/>
    <dbReference type="Ensembl" id="ENSPANT00000035602.2">
        <property type="protein sequence ID" value="ENSPANP00000025138.1"/>
        <property type="gene ID" value="ENSPANG00000026193.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000050080"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026193">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LNT0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019815">
        <property type="term" value="C:B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026072">
        <property type="entry name" value="Lime1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47740:SF1">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47740">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1, LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15332">
        <property type="entry name" value="LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014174068" evidence="2">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="210" mass="21570" checksum="A00A3CA64CDAB7DE" modified="2018-02-28" version="1">MGLPVSWAPPALWVLGCCALLLWLWSLCTACRRPEDALAPRKRVRRQRARLQGSAMGAEAVSARLSRGPGRGPQGTDQPSSPPVPAEADPPLLPQQVGHQTARAAPGPAQQQGPAACQHGSPAPTLAGGVQGHHRTAGSPLCLPAPGAALGSAGSCSHRKVRWPRGHLFQRGAGGPPRGQLGGQPCGGVCPRPEAQRDPTQSPRATAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LR46</accession>
    <name>A0A2I3LR46_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LR46"/>
    <dbReference type="Ensembl" id="ENSPANT00000038654.2">
        <property type="protein sequence ID" value="ENSPANP00000025951.2"/>
        <property type="gene ID" value="ENSPANG00000036144.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166569"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017037">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LR46">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025951.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="45" mass="5223" checksum="7819B331D1E76C9C" modified="2022-05-25" version="2">MLDNYRNLVFLGIAVSKRDLIPCLEQEKEPWNVKTHDMVAKPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M2L0</accession>
    <name>A0A2I3M2L0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DCTN4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900426.1">
        <property type="nucleotide sequence ID" value="XM_003900377.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M2L0"/>
    <dbReference type="Ensembl" id="ENSPANT00000047827.2">
        <property type="protein sequence ID" value="ENSPANP00000029955.1"/>
        <property type="gene ID" value="ENSPANG00000020110.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017720"/>
    <dbReference type="KEGG" id="panu:101017720"/>
    <dbReference type="CTD" id="51164"/>
    <dbReference type="GeneTree" id="ENSGT00390000006954"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020110">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M2L0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="460" mass="52291" checksum="EE7B362EB0457320" modified="2018-02-28" version="1">MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSDKYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLLECEEGDADDINSTAKVVVPPKELILAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVELSLGPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M4D5</accession>
    <accession>A0A096NBA4</accession>
    <name>A0A2I3M4D5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Coiled-coil-helix-coiled-coil-helix domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHCHD4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003906898.1">
        <property type="nucleotide sequence ID" value="XM_003906849.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M4D5"/>
    <dbReference type="SMR" id="A0A2I3M4D5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000030553"/>
    <dbReference type="Ensembl" id="ENSPANT00000017096.3">
        <property type="protein sequence ID" value="ENSPANP00000030553.2"/>
        <property type="gene ID" value="ENSPANG00000025946.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007010"/>
    <dbReference type="KEGG" id="panu:100998223"/>
    <dbReference type="KEGG" id="panu:101007010"/>
    <dbReference type="CTD" id="131474"/>
    <dbReference type="GeneTree" id="ENSGT00390000013132"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025946">
        <property type="expression patterns" value="Expressed in colon and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000001">
        <property type="entry name" value="mitochondrial intermembrane space import and assembly protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="12">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="142" mass="16039" checksum="77562407B8691251" modified="2022-05-25" version="2">MSYCRQEGKDRIIFVTKEDHETPSNAELVADDPNDPYEEHGLILPNGNINWNCPCLGGMASGPCGEQFKSAFSCFHYSTEEIKGSDCVDQFRAMQECMQKYPDLYPQEDEDEEEEREKKPAEQVEETAPTEATATKEEEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M5F2</accession>
    <name>A0A2I3M5F2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M5F2"/>
    <dbReference type="Ensembl" id="ENSPANT00000049864.2">
        <property type="protein sequence ID" value="ENSPANP00000030952.2"/>
        <property type="gene ID" value="ENSPANG00000046807.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074878"/>
    <dbReference type="OMA" id="CELWLST"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032742">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030952.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9662" checksum="797B752C70E265BE" modified="2022-05-25" version="2">MEGPLSMFGDCKTGEAIRSQNVMAAALIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAANVLCELWLSTSLQGSSALYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M8E2</accession>
    <name>A0A2I3M8E2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Supervillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SVIL</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000049258.2">
        <property type="protein sequence ID" value="ENSPANP00000031995.2"/>
        <property type="gene ID" value="ENSPANG00000022931.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154653"/>
    <dbReference type="OMA" id="GKLKHEW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022931">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M8E2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043034">
        <property type="term" value="C:costamere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11280">
        <property type="entry name" value="gelsolin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000017">
        <property type="entry name" value="Supervillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000013">
        <property type="entry name" value="supervillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000015">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000016">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000022">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF45">
        <property type="entry name" value="SUPERVILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="4">
        <location>
            <begin position="1497"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="508"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGD2</accession>
    <name>A0A2I3MGD2_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HEATR6</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003919292.4"/>
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        <property type="protein sequence ID" value="ENSPANP00000034766.2"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="entry name" value="HEAT repeat-containing protein 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.10.10:FF:000505">
        <property type="entry name" value="HEAT repeat-containing protein 6 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
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    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
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    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF13251"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MI84</accession>
    <name>A0A2I3MI84_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">Family with sequence similarity 107 member B</fullName>
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        <name evidence="3" type="primary">FAM107B</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Catarrhini</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
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                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000004612.3"/>
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    <dbReference type="KEGG" id="panu:101024614"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <sequence length="1327" mass="149558" checksum="C7A6F4FD9BB62B71" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021790343.2">
        <property type="nucleotide sequence ID" value="XM_021934651.2"/>
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    <dbReference type="RefSeq" id="XP_021790344.2">
        <property type="nucleotide sequence ID" value="XM_021934652.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I3MKB1"/>
    <dbReference type="SMR" id="A0A2I3MKB1"/>
    <dbReference type="Ensembl" id="ENSPANT00000047019.2">
        <property type="protein sequence ID" value="ENSPANP00000036041.2"/>
        <property type="gene ID" value="ENSPANG00000018156.3"/>
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    <dbReference type="GeneID" id="101006371"/>
    <dbReference type="CTD" id="55669"/>
    <dbReference type="GeneTree" id="ENSGT00390000013727"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Bgee" id="ENSPANG00000018156">
        <property type="expression patterns" value="Expressed in olfactory bulb and 66 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3MKB1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000012">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
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    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
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    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
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    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF2">
        <property type="entry name" value="MITOFUSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="72"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="688"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036041.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="741" mass="84070" checksum="31BB3E016754AE8E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MM40</accession>
    <name>A0A2I3MM40_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
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        <property type="protein sequence ID" value="ENSPANP00000036804.2"/>
        <property type="gene ID" value="ENSPANG00000019914.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154746"/>
    <dbReference type="OMA" id="IKRVVDC"/>
    <dbReference type="UniPathway" id="UPA00193"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Bgee" id="ENSPANG00000019914">
        <property type="expression patterns" value="Expressed in liver and 66 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
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    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
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    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
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        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
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        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
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    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
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    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
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    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
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        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
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        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="23">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="24">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036804.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="777" mass="85219" checksum="6A4D405CC16E2CE1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MN94</accession>
    <name>A0A2I3MN94_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ANKRD42</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017804303.2">
        <property type="nucleotide sequence ID" value="XM_017948814.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I3MN94"/>
    <dbReference type="Ensembl" id="ENSPANT00000045039.2">
        <property type="protein sequence ID" value="ENSPANP00000037243.2"/>
        <property type="gene ID" value="ENSPANG00000009554.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999639"/>
    <dbReference type="CTD" id="338699"/>
    <dbReference type="GeneTree" id="ENSGT00940000154216"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009554">
        <property type="expression patterns" value="Expressed in metanephros cortex and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MN94">
        <property type="expression patterns" value="baseline"/>
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    <dbReference type="FunFam" id="1.25.40.20:FF:000375">
        <property type="entry name" value="ankyrin repeat domain-containing protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="428"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037243.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="529" mass="59287" checksum="B25D8E83FAEB2EE5" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MP69</accession>
    <name>A0A2I3MP69_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">WBP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MP69"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037539"/>
    <dbReference type="Ensembl" id="ENSPANT00000042771.2">
        <property type="protein sequence ID" value="ENSPANP00000037539.1"/>
        <property type="gene ID" value="ENSPANG00000023894.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183109"/>
    <dbReference type="OMA" id="NGSHETW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023894">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MP69">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021684">
        <property type="entry name" value="WBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051994">
        <property type="entry name" value="WW_domain-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209:SF5">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11669">
        <property type="entry name" value="WBP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="302" mass="32603" checksum="276208D3BAE9BD0A" modified="2018-02-28" version="1">MARASSGNGSEEAWGALRASQQQSPAASSLEGAIWRRAGTQTRALDAILYHPQSHLLRELCPGVNNQPYLCESGHCCGETGCCTYYYELWWFWLLWTVLILFSCCCAFRHRRAKLRLQQQQRQREINLLAYHGACHGAGPFPTGSLLDLRLLSTFKPPAYEDVVHRPGTPPPAYTVAPGLPLTASSEQTWCSSSSSCPAHFEGTNVEGVSSHQSAPPHQEVEPAAGVSPAPTPPSCRYRRLTGDSGIELCPCPASGEGEPVKEVRASATLPDLEDYSPCALPPDSVPQVSPMGLSSSEGDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MVZ2</accession>
    <name>A0A2I3MVZ2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MVZ2"/>
    <dbReference type="Ensembl" id="ENSPANT00000055919.2">
        <property type="protein sequence ID" value="ENSPANP00000039938.2"/>
        <property type="gene ID" value="ENSPANG00000048676.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154293"/>
    <dbReference type="OMA" id="CCCNSPM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000036089">
        <property type="expression patterns" value="Expressed in spleen and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04984">
        <property type="entry name" value="IgV_L_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000442">
        <property type="entry name" value="Immunoglobulin lambda variable 2-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035318273" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039938.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="228" mass="24312" checksum="433877992E5CB117" modified="2022-05-25" version="2">MTWSPLLLTLLIHCTGSWAQSVLTQPPSVSGDPGQRVTISCTGSSSNIGGYYVYWYQQLPGTAPKLLIYDNNKRPSGVSDRFSGSKSGTSASLTITGLQPGDEADYYCGAWDSSLSAHTVLQANGELRQEPPSSSARRVSACSCCSRLTCSFCCCSFPHGPRGSQGPAKSGNSLTFVLRVRNRASRKQNILLLQFEAQGLCTEILGLGGRSTCVFTDPPVPAHGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N6S5</accession>
    <name>A0A2I3N6S5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KIAA0930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KIAA0930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N6S5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000043576"/>
    <dbReference type="Ensembl" id="ENSPANT00000042378.2">
        <property type="protein sequence ID" value="ENSPANP00000043576.2"/>
        <property type="gene ID" value="ENSPANG00000009725.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004190"/>
    <dbReference type="OMA" id="SAATHCH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009725">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N6S5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043576.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="454" mass="50313" checksum="87D5769114CB684C" modified="2022-05-25" version="2">MNRGQHGLRAAAGRACASASAPAGLRAGPPAVPAAPEPAGGAETGRSLRRTPVPRGGAAAPPSLRREVCGLGCFKDDRIVFWTWMFSTYFMEKWAPRQDDMLFYVRRKLAYSGSESGADGRKATEPEVEVEVYRRDSKKLPGLGDPDIDWEESVCLNLILQKLDYMVTCAVCTRADGGDIHIHKKKSQQVFASPSKHPMDSKGEESKISYPNIFFMIDSFEEVFSDMTVGEGEMVCVELVASDKSNTFQGVIFQGSIRYEALKKVYDNRVSVAARMAQKMSFGFYKYNNMEFVRMKGPQGKGHAEMAVSRVSTGDTSPCGTEEDSSPASPMHERVTSFSTPPTPERNNRPAFFSPSLKRKVPRNRIAEMKKSHSANDSEEFFREDDGGADLHNATNLRSRSLSGTGRSLVGSWLKLNRADGNFLLYAHLTYVTLPLHRILTDILEVRQKPILMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N923</accession>
    <name>A0A2I3N923_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Prostaglandin E synthase</fullName>
            <ecNumber evidence="7">2.5.1.18</ecNumber>
            <ecNumber evidence="6">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Glutathione peroxidase PTGES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Glutathione transferase PTGES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Microsomal prostaglandin E synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">PTGES</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:53324"/>
            <dbReference type="ChEBI" id="CHEBI:85166"/>
            <dbReference type="ChEBI" id="CHEBI:137172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:53325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:64364"/>
            <dbReference type="ChEBI" id="CHEBI:82629"/>
            <dbReference type="ChEBI" id="CHEBI:152564"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:64365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="7"/>
    <dbReference type="EC" id="5.3.99.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3N923"/>
    <dbReference type="SMR" id="A0A2I3N923"/>
    <dbReference type="STRING" id="9555.ENSPANP00000044391"/>
    <dbReference type="Ensembl" id="ENSPANT00000055529.2">
        <property type="protein sequence ID" value="ENSPANP00000044391.1"/>
        <property type="gene ID" value="ENSPANG00000032931.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011980"/>
    <dbReference type="OMA" id="TIAQIPC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032931">
        <property type="expression patterns" value="Expressed in cornea and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004667">
        <property type="term" value="F:prostaglandin-D synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032308">
        <property type="term" value="P:positive regulation of prostaglandin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031620">
        <property type="term" value="P:regulation of fever generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF9">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 30" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00039926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00041613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00042011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00042173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00054772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="152" mass="17116" checksum="5D50D2CCB6CA89F7" modified="2018-02-28" version="1">MPAHSLAMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLLGRVVHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N9G3</accession>
    <name>A0A2I3N9G3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Extended synaptotagmin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ESYT1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N9G3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000044531"/>
    <dbReference type="Ensembl" id="ENSPANT00000048091.2">
        <property type="protein sequence ID" value="ENSPANP00000044531.2"/>
        <property type="gene ID" value="ENSPANG00000017046.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156561"/>
    <dbReference type="OMA" id="KVHPGQS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017046">
        <property type="expression patterns" value="Expressed in mesenteric fat pad and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N9G3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120014">
        <property type="term" value="F:phospholipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08391">
        <property type="entry name" value="C2A_C2C_Synaptotagmin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04050">
        <property type="entry name" value="C2B_Synaptotagmin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd21679">
        <property type="entry name" value="SMP_ESyt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000106">
        <property type="entry name" value="extended synaptotagmin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000120">
        <property type="entry name" value="extended synaptotagmin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000139">
        <property type="entry name" value="extended synaptotagmin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037733">
        <property type="entry name" value="Ext_Synaptotagmin_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037749">
        <property type="entry name" value="Ext_Synaptotagmin_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF3">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="18">
        <location>
            <begin position="135"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="312"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="437"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="598"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="748"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="942"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1119" mass="123936" checksum="1BF8450C93570058" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N9I4</accession>
    <name>A0A2I3N9I4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TatD DNase domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TATDN3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Exhibits 3'-exonuclease activities and apurinic/apyrimidinic (AP) endonuclease (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918843.1">
        <property type="nucleotide sequence ID" value="XM_003918794.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N9I4"/>
    <dbReference type="Ensembl" id="ENSPANT00000036506.2">
        <property type="protein sequence ID" value="ENSPANP00000044673.2"/>
        <property type="gene ID" value="ENSPANG00000026097.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011106"/>
    <dbReference type="KEGG" id="panu:101011106"/>
    <dbReference type="CTD" id="128387"/>
    <dbReference type="GeneTree" id="ENSGT00720000108846"/>
    <dbReference type="OMA" id="HTHLDMQ"/>
    <dbReference type="OrthoDB" id="9521718at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026097">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46317:SF7">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46317">
        <property type="entry name" value="HYDROLASE OF PHP SUPERFAMILY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044673.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="274" mass="30339" checksum="605CD46D634C014F" modified="2022-05-25" version="2">MGAARVGLVDCHCHISAPDFDRDLDDVLEKAKKGNVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPVQGLSPEDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTDEQKEEQRQVLIRQIQLAKRLNLPVNVHSRSAGRPTINLLQEQGADKVLLHAFDGRPSVAMEGVRAGYFFSIPPSIIRSGQKQKLVKQLPLTSICLETDSPALGPEKQVRNEPWNVSISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NCJ3</accession>
    <name>A0A2I3NCJ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BUB3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1. Interacts with ZNF207/BuGZ; leading to promote stability and kinetochore loading of BUB3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017799896.1">
        <property type="nucleotide sequence ID" value="XM_017944407.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799897.1">
        <property type="nucleotide sequence ID" value="XM_017944408.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799898.1">
        <property type="nucleotide sequence ID" value="XM_017944409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NCJ3"/>
    <dbReference type="Ensembl" id="ENSPANT00000039719.2">
        <property type="protein sequence ID" value="ENSPANP00000045563.2"/>
        <property type="gene ID" value="ENSPANG00000020351.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011923"/>
    <dbReference type="CTD" id="9184"/>
    <dbReference type="GeneTree" id="ENSGT00950000183091"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020351">
        <property type="expression patterns" value="Expressed in thymus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NCJ3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045563.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="329" mass="37295" checksum="11C95FB834B7368E" modified="2022-05-25" version="2">MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKYGNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3ND74</accession>
    <name>A0A2I3ND74_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RAR related orphan receptor A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017817118.1">
        <property type="nucleotide sequence ID" value="XM_017961629.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3ND74"/>
    <dbReference type="Ensembl" id="ENSPANT00000045520.2">
        <property type="protein sequence ID" value="ENSPANP00000045930.1"/>
        <property type="gene ID" value="ENSPANG00000017172.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101002940"/>
    <dbReference type="CTD" id="6095"/>
    <dbReference type="GeneTree" id="ENSGT00940000157387"/>
    <dbReference type="OMA" id="LEPSKWQ"/>
    <dbReference type="OrthoDB" id="8832025at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017172">
        <property type="expression patterns" value="Expressed in zone of skin and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3ND74">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06968">
        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06939">
        <property type="entry name" value="NR_LBD_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000005">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003079">
        <property type="entry name" value="ROR_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF3">
        <property type="entry name" value="NUCLEAR RECEPTOR ROR-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01293">
        <property type="entry name" value="RORNUCRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="272"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58989" checksum="CCA43BA445E8BED5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NEA2</accession>
    <name>A0A2I3NEA2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch repeat and BTB domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KBTBD4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003909967.1">
        <property type="nucleotide sequence ID" value="XM_003909918.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NEA2"/>
    <dbReference type="Ensembl" id="ENSPANT00000033649.2">
        <property type="protein sequence ID" value="ENSPANP00000046178.1"/>
        <property type="gene ID" value="ENSPANG00000017205.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019928"/>
    <dbReference type="KEGG" id="panu:101019928"/>
    <dbReference type="CTD" id="55709"/>
    <dbReference type="GeneTree" id="ENSGT00940000158775"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017205">
        <property type="expression patterns" value="Expressed in pineal body and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NEA2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd18481">
        <property type="entry name" value="BACK_KBTBD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18272">
        <property type="entry name" value="BTB_POZ_KBTBD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042884">
        <property type="entry name" value="KBTBD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042950">
        <property type="entry name" value="KBTBD4_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042949">
        <property type="entry name" value="KBTBD4_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47195">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47195:SF1">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="534" mass="59866" checksum="055EE08883191B42" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NG93</accession>
    <name>A0A2I3NG93_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FUN14 domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Hepatitis C virus core-binding protein 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways. May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918540.3">
        <property type="nucleotide sequence ID" value="XM_003918491.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NG93"/>
    <dbReference type="Ensembl" id="ENSPANT00000055792.2">
        <property type="protein sequence ID" value="ENSPANP00000047014.2"/>
        <property type="gene ID" value="ENSPANG00000004381.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004214"/>
    <dbReference type="KEGG" id="panu:101004214"/>
    <dbReference type="CTD" id="65991"/>
    <dbReference type="GeneTree" id="ENSGT00940000154783"/>
    <dbReference type="OMA" id="AAPSFKM"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004381">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NG93">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF5">
        <property type="entry name" value="FUN14 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047014.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="189" mass="20674" checksum="627FE3C7A841C859" modified="2022-05-25" version="2">METSAPRAGSQVVATTERHSAACRADPLRVSSRDKLTEMAASTQGNFDGNFESLDLAEFAKKQPWWRKLFGQESGPSAEKYSVATQLFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVRSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MV68</accession>
    <name>A0A8I5MV68_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Interleukin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IL37</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the IL-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MV68"/>
    <dbReference type="Ensembl" id="ENSPANT00000063071.1">
        <property type="protein sequence ID" value="ENSPANP00000048399.1"/>
        <property type="gene ID" value="ENSPANG00000041156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182943"/>
    <dbReference type="OMA" id="HAGPRVK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005149">
        <property type="term" value="F:interleukin-1 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002437">
        <property type="term" value="P:inflammatory response to antigenic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000013">
        <property type="entry name" value="Interleukin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000975">
        <property type="entry name" value="IL-1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078">
        <property type="entry name" value="INTERLEUKIN-1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078:SF31">
        <property type="entry name" value="INTERLEUKIN-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00340">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00264">
        <property type="entry name" value="INTERLEUKIN1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01357">
        <property type="entry name" value="INTRLEUKN1AB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00125">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="254" mass="28336" checksum="FD89F16AFC0BA8CE" modified="2022-05-25" version="1">MRPWTSFHFLMSNNSALKMSFVGENSGVKMGSEDWEKDEPQCYSEKDEPQCYSEKDEPQCYSEDLAGSPLEPGPSLPSMNFVHTSPKVKNLNPKKFSIHDQDHKVLVVDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLSCDKDKGQSHPSLQLKKKKLMKLAALKESARRPFIFYRAQVGSRNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MWA8</accession>
    <name>A0A8I5MWA8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031506221.1">
        <property type="nucleotide sequence ID" value="XM_031650361.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506222.1">
        <property type="nucleotide sequence ID" value="XM_031650362.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506224.1">
        <property type="nucleotide sequence ID" value="XM_031650364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MWA8"/>
    <dbReference type="SMR" id="A0A8I5MWA8"/>
    <dbReference type="Ensembl" id="ENSPANT00000062927.1">
        <property type="protein sequence ID" value="ENSPANP00000049384.1"/>
        <property type="gene ID" value="ENSPANG00000039716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116268849"/>
    <dbReference type="GeneTree" id="ENSGT00940000153544"/>
    <dbReference type="OMA" id="KMENWQQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd05627">
        <property type="entry name" value="STKc_NDR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.200.20:FF:000118">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
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    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
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    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
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    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="90"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="384"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="464" mass="53987" checksum="A286873C17B188CA" modified="2022-05-25" version="1">MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXF1</accession>
    <name>A0A8I5MXF1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXF1"/>
    <dbReference type="Ensembl" id="ENSPANT00000083394.1">
        <property type="protein sequence ID" value="ENSPANP00000050325.1"/>
        <property type="gene ID" value="ENSPANG00000046474.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263676"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="50" mass="5754" checksum="6C52451D386C61AC" modified="2022-05-25" version="1">FSRFTPFSCLSLPSSWDYRRPPPRPAKFFVFLVETGFHCVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXI1</accession>
    <name>A0A8I5MXI1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXI1"/>
    <dbReference type="Ensembl" id="ENSPANT00000063114.1">
        <property type="protein sequence ID" value="ENSPANP00000050385.1"/>
        <property type="gene ID" value="ENSPANG00000038388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="95" mass="10777" checksum="DCCA515BF6DEDCDA" modified="2022-05-25" version="1">GLVSGTSAVRKTPNFFFFFFFFEAESRSVAQAGVQWRDLGSLQAPPPGFTPFSCLSLPSSWDYRRRHHARLIFCIFLVEMGFHRVSQDGLDLVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0R3</accession>
    <name>A0A8I5N0R3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Lecithin retinol acyltransferase</fullName>
            <ecNumber evidence="25">2.3.1.135</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Phosphatidylcholine--retinol O-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LRAT</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]</text>
            <dbReference type="Rhea" id="RHEA:56248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14426"/>
            <dbReference type="Rhea" id="RHEA-COMP:14428"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:65211"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="ChEBI" id="CHEBI:140088"/>
            <dbReference type="ChEBI" id="CHEBI:140089"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:56249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = all-trans-retinyl heptanoate + 2-heptanoyl-sn-glycero-3-phosphocholine + apo--[retinol-binding protein]</text>
            <dbReference type="Rhea" id="RHEA:55320"/>
            <dbReference type="Rhea" id="RHEA-COMP:14426"/>
            <dbReference type="Rhea" id="RHEA-COMP:14428"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="ChEBI" id="CHEBI:138195"/>
            <dbReference type="ChEBI" id="CHEBI:138266"/>
            <dbReference type="ChEBI" id="CHEBI:138724"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:55321"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43904"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
            <dbReference type="ChEBI" id="CHEBI:76078"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:43905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]</text>
            <dbReference type="Rhea" id="RHEA:56240"/>
            <dbReference type="Rhea" id="RHEA-COMP:14426"/>
            <dbReference type="Rhea" id="RHEA-COMP:14428"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="ChEBI" id="CHEBI:140082"/>
            <dbReference type="ChEBI" id="CHEBI:140084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:56241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>all-trans-retinol--[retinol-binding protein] + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:56244"/>
            <dbReference type="Rhea" id="RHEA-COMP:14426"/>
            <dbReference type="Rhea" id="RHEA-COMP:14428"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
            <dbReference type="ChEBI" id="CHEBI:76078"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:56245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:17469"/>
            <dbReference type="Rhea" id="RHEA-COMP:14426"/>
            <dbReference type="Rhea" id="RHEA-COMP:14428"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="EC" id="2.3.1.135"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:17470"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.135" evidence="25"/>
    <dbReference type="RefSeq" id="XP_021794578.2">
        <property type="nucleotide sequence ID" value="XM_021938886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0R3"/>
    <dbReference type="Ensembl" id="ENSPANT00000073124.1">
        <property type="protein sequence ID" value="ENSPANP00000048968.1"/>
        <property type="gene ID" value="ENSPANG00000037568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101020435"/>
    <dbReference type="KEGG" id="panu:101020435"/>
    <dbReference type="CTD" id="9227"/>
    <dbReference type="GeneTree" id="ENSGT00510000047351"/>
    <dbReference type="OMA" id="PFCLWMV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016416">
        <property type="term" value="F:O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047173">
        <property type="term" value="F:phosphatidylcholine-retinol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032370">
        <property type="term" value="P:positive regulation of lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006776">
        <property type="term" value="P:vitamin A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1720.10:FF:000006">
        <property type="entry name" value="Lecithin retinol acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042288">
        <property type="entry name" value="LRAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46678">
        <property type="entry name" value="LECITHIN RETINOL ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46678:SF1">
        <property type="entry name" value="LECITHIN RETINOL ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="30" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0844">Vision</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035327067" description="Lecithin retinol acyltransferase" evidence="30">
        <location>
            <begin position="32"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="31">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="28">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00066417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00072314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00082402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR642288-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="230" mass="25803" checksum="7A3C2460AEB7DEE9" modified="2022-05-25" version="1">MKNPMLEVVSLLLEKLLLISNFTLFSSGTTGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDLGRTQKVVSNKRLILGVIVRVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCMGLVSYTTLPAIFIPFFLWMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N317</accession>
    <name>A0A8I5N317_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the humanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N317"/>
    <dbReference type="Ensembl" id="ENSPANT00000076188.1">
        <property type="protein sequence ID" value="ENSPANP00000050713.1"/>
        <property type="gene ID" value="ENSPANG00000047796.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000289392"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900118">
        <property type="term" value="P:negative regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20245">
        <property type="entry name" value="humanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028139">
        <property type="entry name" value="Humanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33895:SF18">
        <property type="entry name" value="HUMANIN-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33895">
        <property type="entry name" value="HUMANIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15040">
        <property type="entry name" value="Humanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="24" mass="2718" checksum="14DC7D48F4B0B971" modified="2022-05-25" version="1">MAPRGFNCLLLSTSEIDLPVKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N576</accession>
    <name>A0A8I5N576_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural molecule activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Retrovr_matrix"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="664"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="765"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="19">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024963"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00506"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
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    <evidence type="ECO:0000313" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="91246" checksum="157B130C76CFF3C3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8J1</accession>
    <name>A0A8I5N8J1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Torsin-1A-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TOR1AIP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOR1AIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031513927.1">
        <property type="nucleotide sequence ID" value="XM_031658067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8J1"/>
    <dbReference type="Ensembl" id="ENSPANT00000072077.1">
        <property type="protein sequence ID" value="ENSPANP00000057132.1"/>
        <property type="gene ID" value="ENSPANG00000010531.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026977"/>
    <dbReference type="KEGG" id="panu:101026977"/>
    <dbReference type="CTD" id="26092"/>
    <dbReference type="GeneTree" id="ENSGT00390000012166"/>
    <dbReference type="OMA" id="NASFVKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12190:FF:000001">
        <property type="entry name" value="torsin-1A-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008662">
        <property type="entry name" value="TOIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046753">
        <property type="entry name" value="TOIP1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046754">
        <property type="entry name" value="TOIP1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843:SF6">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05609">
        <property type="entry name" value="LAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20443">
        <property type="entry name" value="LAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Torsin-1A-interacting protein 1/2 N-terminal" evidence="16">
        <location>
            <begin position="282"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A-interacting protein 1/2 AAA+ activator" evidence="15">
        <location>
            <begin position="521"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="251"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="750" mass="84509" checksum="3B8481F8862F41A2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NA40</accession>
    <name>A0A8I5NA40_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Beta-synuclein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SNCB</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis. Interacts with UCHL1. Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity. Interacts with RPH3A and RAB3A. Interacts with SERF1A; this interaction promotes the aggregation of SNCA. Interacts with SEPTIN4. Interacts with DDX10; this interaction causes DDX10 mislocalization to the nucleoplasm and cytoplasmic inclusions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the synuclein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900618.1">
        <property type="nucleotide sequence ID" value="XM_003900569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NA40"/>
    <dbReference type="Ensembl" id="ENSPANT00000072946.1">
        <property type="protein sequence ID" value="ENSPANP00000053519.1"/>
        <property type="gene ID" value="ENSPANG00000014009.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019860"/>
    <dbReference type="KEGG" id="panu:101019860"/>
    <dbReference type="CTD" id="6620"/>
    <dbReference type="GeneTree" id="ENSGT00950000183175"/>
    <dbReference type="OMA" id="GWRERWM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016234">
        <property type="term" value="C:inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Alpha-synuclein"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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        <property type="entry name" value="Synuclein_beta"/>
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        <property type="entry name" value="Synuclein"/>
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        <property type="entry name" value="Synuclein"/>
        <property type="match status" value="1"/>
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    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
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    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="134"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="98"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050012"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056203"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
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        </source>
    </evidence>
    <sequence length="134" mass="14288" checksum="5BCA9FCA615AC4EF" modified="2022-05-25" version="1">MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBL1</accession>
    <name>A0A8I5NBL1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBL1"/>
    <dbReference type="Ensembl" id="ENSPANT00000082426.1">
        <property type="protein sequence ID" value="ENSPANP00000057617.1"/>
        <property type="gene ID" value="ENSPANG00000048918.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="140" mass="16264" checksum="85C9193F8A274996" modified="2022-05-25" version="1">MIRTWFLSLVFSVPCIQFWVHFLAVFCLMVPRWQLLRIPRQSRKNEKDTGLLTRVDGVTFFLSFFFFFFFETESRSVAQAGVQWPDLSSLQAPPPGFTPFSCLSLPSSWDYRCPLPRPASFLYFLVERGFTGLARMVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC91</accession>
    <name>A0A8I5NC91_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC91"/>
    <dbReference type="Ensembl" id="ENSPANT00000073030.1">
        <property type="protein sequence ID" value="ENSPANP00000051176.1"/>
        <property type="gene ID" value="ENSPANG00000041255.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="OMA" id="ILACWSE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274899" evidence="2">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="91" mass="10280" checksum="56FD8C16DF94C6C1" modified="2022-05-25" version="1">EFLHLCLLVILACWSEVCDLRSLQPLPPWFKRFSCLSLPSSWDYRHAPPHPGNFVFLVEMMFLHVGQAGLELPTSGDPLPPRPPKVMGLQA</sequence>
</entry>
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    <accession>A0A8I5NDB6</accession>
    <name>A0A8I5NDB6_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NDB6"/>
    <dbReference type="Ensembl" id="ENSPANT00000077197.1">
        <property type="protein sequence ID" value="ENSPANP00000060152.1"/>
        <property type="gene ID" value="ENSPANG00000041741.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="110" mass="12710" checksum="A112E10F6D2230B6" modified="2022-05-25" version="1">MPITETKVSQDNIDAQYIQCTLIFSFFFFFLFLFFFFETESCSVAQAGVQWPDLSSLQAPPPGFTPFSCLSLPRSWDYRCLPPRLANFFVFLVETGFHRVRQEGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFC5</accession>
    <name>A0A8I5NFC5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MT1G</name>
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    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Tang L.-Y.T."/>
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                <person name="Tisius J.T."/>
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                <person name="Usmani K.U."/>
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                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallothionein superfamily. Type 1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000052978.1"/>
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        <property type="component" value="Chromosome 18"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to cadmium ion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071294">
        <property type="term" value="P:cellular response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010273">
        <property type="term" value="P:detoxification of copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Metallothionein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.10.10">
        <property type="entry name" value="Metallothionein Isoform II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017854">
        <property type="entry name" value="Metalthion_dom_sf"/>
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        <property type="entry name" value="Metalthion_dom_sf_vert"/>
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    <dbReference type="InterPro" id="IPR000006">
        <property type="entry name" value="Metalthion_vert"/>
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    <dbReference type="InterPro" id="IPR018064">
        <property type="entry name" value="Metalthion_vert_metal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23299">
        <property type="entry name" value="METALLOTHIONEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23299:SF22">
        <property type="entry name" value="METALLOTHIONEIN-1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00131">
        <property type="entry name" value="Metallothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00860">
        <property type="entry name" value="MTVERTEBRATE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57868">
        <property type="entry name" value="Metallothionein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00203">
        <property type="entry name" value="METALLOTHIONEIN_VRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="58" mass="5785" checksum="65152547FDB02D52" modified="2022-05-25" version="1">MDTNGSCGSCTCSGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGALDKCSCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGF2</accession>
    <name>A0A8I5NGF2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGF2"/>
    <dbReference type="Ensembl" id="ENSPANT00000070325.1">
        <property type="protein sequence ID" value="ENSPANP00000048262.1"/>
        <property type="gene ID" value="ENSPANG00000048384.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="NTECEWI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="15">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="14">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="16">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="39603" checksum="C4DA3BDCD2E3741E" modified="2022-05-25" version="1">MGKKQGRKAGNSKNKSASPPAKERSSSPAMDQSWTENDFDEMREEGFSPSNFSELKEELRTQRKETKNLEKKVEELMTRVINAEKVLNEMKEMKTMTREICDKCTSFSNRLDQLEERVSAIEDQMNEMKREEKPKEKRRKRNEQSLQEVWDYVKRPNLRLIGVPESEGENGTKLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSSRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTADLSAETLQARREWGPIFNILKEKNFQPRISYPAKLSFISEGEIKSFTDKQMLRDFVTTRPALQETLKEALNMEGNNRYQPWQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHK2</accession>
    <name>A0A8I5NHK2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHK2"/>
    <dbReference type="Ensembl" id="ENSPANT00000078812.1">
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        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="140" mass="15108" checksum="FC496B74F8EABA58" modified="2022-05-25" version="1">GRAWRPCARHAEAPPASDICLSLQGFQVAYVVFQKPSGVSAALALKGPLLVSTESHPVKSGIHKWISDYADSMPDPEALRVEVDTFMEAHDQKIAEVEAPQGWPSTASPVWLWEGGAPEGGRWRPVLSHSVGRLPFPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHT3</accession>
    <name>A0A8I5NHT3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHT3"/>
    <dbReference type="Ensembl" id="ENSPANT00000078198.1">
        <property type="protein sequence ID" value="ENSPANP00000054646.1"/>
        <property type="gene ID" value="ENSPANG00000037587.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163368"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
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        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="88" mass="9528" checksum="86D586FA75AFAE0E" modified="2022-05-25" version="1">QQRTLSLIQHTKNSSSNSSSVSNPTNVLVCKLRLEVSAKAACTSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIVKKLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLE0</accession>
    <name>A0A8I5NLE0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 178A</fullName>
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    </protein>
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        <name evidence="14" type="primary">TMEM178A</name>
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    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with STIM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM178 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908591.1">
        <property type="nucleotide sequence ID" value="XM_003908542.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLE0"/>
    <dbReference type="Ensembl" id="ENSPANT00000062826.1">
        <property type="protein sequence ID" value="ENSPANP00000058908.1"/>
        <property type="gene ID" value="ENSPANG00000040337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101024378"/>
    <dbReference type="KEGG" id="panu:101024378"/>
    <dbReference type="CTD" id="130733"/>
    <dbReference type="GeneTree" id="ENSGT00390000015299"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045671">
        <property type="term" value="P:negative regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000024">
        <property type="entry name" value="Transmembrane protein 178A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039625">
        <property type="entry name" value="T178A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="297" mass="33019" checksum="757C5C9F7F2CFA53" modified="2022-05-25" version="1">MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRADPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASISYDLNRLPKLIYSLPADVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAQLKSGRDSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMT4</accession>
    <name>A0A8I5NMT4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NMT4"/>
    <dbReference type="Ensembl" id="ENSPANT00000075013.1">
        <property type="protein sequence ID" value="ENSPANP00000059724.1"/>
        <property type="gene ID" value="ENSPANG00000051194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="116" mass="12802" checksum="AD734952D4BAEC9E" modified="2022-05-25" version="1">MTFSIFSWAYWHSMSLISKNVYSNTLPNFLIGCFSLFFVFEMASLSVTKAGVQWHNLGSLHPPPPGLKRFSCLSLPSTWDYRCSLTLSPRLECNGAIPAHCNLRLPGSSNSPASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNW0</accession>
    <name>A0A8I5NNW0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UFC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 6">E2-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with UBA5 (via C-terminus). Interacts with UFL1. Interacts with UFM1. Interacts with KIRREL3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031510674.1">
        <property type="nucleotide sequence ID" value="XM_031654814.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510683.1">
        <property type="nucleotide sequence ID" value="XM_031654823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNW0"/>
    <dbReference type="SMR" id="A0A8I5NNW0"/>
    <dbReference type="Ensembl" id="ENSPANT00000062373.1">
        <property type="protein sequence ID" value="ENSPANP00000058091.1"/>
        <property type="gene ID" value="ENSPANG00000041377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103878805"/>
    <dbReference type="KEGG" id="panu:103878805"/>
    <dbReference type="CTD" id="51506"/>
    <dbReference type="GeneTree" id="ENSGT00390000008196"/>
    <dbReference type="OMA" id="LWQKNVP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032649">
        <property type="term" value="P:regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000042">
        <property type="entry name" value="Ubiquitin-fold modifier-conjugating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008716">
        <property type="entry name" value="DUF1782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR008716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR008716-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="167" mass="19458" checksum="1675D9187DC43E14" modified="2022-05-25" version="1">MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQG9</accession>
    <name>A0A8I5NQG9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP2 sterol binding domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SCP2D1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003905171.1">
        <property type="nucleotide sequence ID" value="XM_003905122.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NQG9"/>
    <dbReference type="Ensembl" id="ENSPANT00000069668.1">
        <property type="protein sequence ID" value="ENSPANP00000051496.1"/>
        <property type="gene ID" value="ENSPANG00000048632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101000293"/>
    <dbReference type="KEGG" id="panu:101000293"/>
    <dbReference type="CTD" id="140856"/>
    <dbReference type="GeneTree" id="ENSGT00940000154327"/>
    <dbReference type="OMA" id="WDIMNGG"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="156" mass="17485" checksum="E2CA229FFE06E9BE" modified="2022-05-25" version="1">MWKRSGHQPKIKAEDGPLAGQFEVLGSVPEPAMPHPLELSELESFSVFEDIRLHIREVGAQLVKKVNAIFQLDITKDGKIILQWTIDLKNGSGDMYPGPARLPADTVFTIPEPVFMELVLGKMNPQKAFLAGKFKVSGKVLLSQKLERVFKDWAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NT18</accession>
    <name>A0A8I5NT18_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NT18"/>
    <dbReference type="Ensembl" id="ENSPANT00000061226.1">
        <property type="protein sequence ID" value="ENSPANP00000054566.1"/>
        <property type="gene ID" value="ENSPANG00000047991.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="OMA" id="FFVMESH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="142" mass="16052" checksum="56018C4BFEEFAE67" modified="2022-05-25" version="1">MRLPNVLETHSLPQCSQDASMESKEIILQLQACFLFVCLIVLFFFFVMESHSSFCHPGWQWHDLGSLQPLPPGFKRFSCLSLLSNWNYRHVLPCLANFFVFLVETGFYHVGQAGLELLTSRDPPASASQSAGITGMNHCTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NTH9</accession>
    <name>A0A8I5NTH9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NTH9"/>
    <dbReference type="Ensembl" id="ENSPANT00000078649.1">
        <property type="protein sequence ID" value="ENSPANP00000058156.1"/>
        <property type="gene ID" value="ENSPANG00000042547.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064285"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01327">
        <property type="entry name" value="KAZAL_PSTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000031">
        <property type="entry name" value="Serine protease inhibitor Kazal-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042167">
        <property type="entry name" value="SPINK2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47608:SF1">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47608">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 2, SPINK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="242" mass="25261" checksum="5E974C1C31898FB8" modified="2022-05-25" version="1">MSEGEVFPLVSSAGRRGCGATTAPSSISLAPSFPMAPSPVLLPFSFPALPGSPSTLHGSSSRRPSCLRHLPLHFLPLSPRPFFLPSPALPAPLASGAGTRAQGPDARRGRRMALAVLRLALLLLAVTFAGSARSGPGERGPLEKSGRGSHAGGGPCPALGGLGDGTRAAVTGGSPEDLPGPLFRRFSKYKTPFCARYQLPGCPRDFNPVCGTDMITYPNECTLCMKIRESGQNIKIFRRGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU41</accession>
    <name>A0A8I5NU41_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable tRNA(His) guanylyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU41"/>
    <dbReference type="Ensembl" id="ENSPANT00000080301.1">
        <property type="protein sequence ID" value="ENSPANP00000058768.1"/>
        <property type="gene ID" value="ENSPANG00000045161.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011705"/>
    <dbReference type="OMA" id="FSHIRSC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="3">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="123" mass="14458" checksum="F468991B341E9E2B" modified="2022-05-25" version="1">MWAACKVKVHDYLATTSITLRQCLRLGATMAKSKFEYVRDFEADDTCLAHCWVVVRLDGRNFHRFAEKHSFAKPNDSRALHLMTKCAQTVMEELEDIVIAYGQSDEYSFVFKRKTNWFKRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUU4</accession>
    <name>A0A8I5NUU4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">28S ribosomal protein S18-1, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S18c, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUU4"/>
    <dbReference type="Ensembl" id="ENSPANT00000051324.2">
        <property type="protein sequence ID" value="ENSPANP00000056414.1"/>
        <property type="gene ID" value="ENSPANG00000033621.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003791"/>
    <dbReference type="OMA" id="CICGRHK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000007">
        <property type="entry name" value="28S ribosomal protein S18c, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF56">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="109" mass="12283" checksum="FA353CAFBD9926BE" modified="2022-05-25" version="1">MATIVAVCSGLGRKKLTHLVMAAVSLTHPRTHVVLWRRGYFKNVQLLSQFISPFIGCICGRHKTGLCGKKQKEITKAIKRPQIIGLMPVTYKDAAYLKDPKVCNIRYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYL4</accession>
    <name>A0A8I5NYL4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OR5BS1P</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NYL4"/>
    <dbReference type="Ensembl" id="ENSPANT00000071474.1">
        <property type="protein sequence ID" value="ENSPANP00000056094.1"/>
        <property type="gene ID" value="ENSPANG00000041563.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163803"/>
    <dbReference type="OMA" id="FLECFTQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000015">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="311" mass="34125" checksum="3BC54A3F57B0B6BF" modified="2022-05-25" version="1">MEVSNMTTVTVFVLLGQSNHPQVQALLFVLFLAIYLLTLLGNLLMVLVISTDSHLHTPMYFFLRHLSFLDAFYASIIVPKLLENLLSKEKTISFLECFTQISLVIFAGATEACLLSVMAYDRFQAVCHPLLYVVVMNRRVCAGLVGSSWAIGIGTGLINTLLLAQQHFCGPNVIRSFACELPPVLLLTCSNPCASIASILTTMSVLGLGTLVLLLGSYSCIITTALRINSATGRNKIFSTCSSQFLMVTIFYTSGVLRYMIPASGSALEQVLSVQYSVITPLLNPLIYSLKNQEVKVALRRMLARKSRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZ60</accession>
    <name>A0A8I5QZ60_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-amylase</fullName>
            <ecNumber evidence="5 13">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZ60"/>
    <dbReference type="Ensembl" id="ENSPANT00000083512.1">
        <property type="protein sequence ID" value="ENSPANP00000048093.1"/>
        <property type="gene ID" value="ENSPANG00000047597.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154802"/>
    <dbReference type="OMA" id="EHREVWS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000056">
        <property type="entry name" value="Pancreatic alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035167520" description="Alpha-amylase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="26"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="15">
        <location>
            <begin position="403"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="491" mass="55386" checksum="D6C081BCC3036E84" modified="2022-05-25" version="1">MKFFLLLLTIGFCWAQYSPNTQQGRTSIVHLFEWRWADIALECERYLAPKGFGGVQVSPPNENVAIHNPSRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTSSGDIENYNDATQVRDCRLTGLLDLALEKDYVRSKIAEYMNNLIDMGVAGFRLDASKHMWPGDIKAVLDKLHNLNSNWFPQGSKPFIYQEVIDLGGEPIKSSEYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRNFQNGKDVNDYTPNNNGAIEEVTINPDTTCGKWTGSWMRAFTNWYDNGRFIVFNNDDLVSKYQLKYILSFSLTLQTGLPAGTYCDVISGDKIDGNCTGIKIYVSNDGKAQFSISNSAEDPFIAIHVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZ84</accession>
    <name>A0A8I5QZ84_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="16">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PLCZ1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003906128.1">
        <property type="nucleotide sequence ID" value="XM_003906079.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZ84"/>
    <dbReference type="Ensembl" id="ENSPANT00000070563.1">
        <property type="protein sequence ID" value="ENSPANP00000048357.1"/>
        <property type="gene ID" value="ENSPANG00000012068.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998995"/>
    <dbReference type="KEGG" id="panu:100998995"/>
    <dbReference type="CTD" id="89869"/>
    <dbReference type="GeneTree" id="ENSGT00940000159950"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060470">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration involved in egg activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08595">
        <property type="entry name" value="PI-PLCc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000357">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000147">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000027">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF29">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="18">
        <location>
            <begin position="349"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="465"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="608" mass="70556" checksum="FFF03BFAEA58246F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R009</accession>
    <name>A0A8I5R009_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin XVB</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
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        <property type="protein sequence ID" value="ENSPANP00000050854.1"/>
        <property type="gene ID" value="ENSPANG00000020136.3"/>
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    <dbReference type="GeneTree" id="ENSGT00930000151032"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12068">
        <property type="entry name" value="SH3_MYO15B"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Band_41_domain"/>
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    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
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    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
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    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
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    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
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        <property type="entry name" value="MYO15"/>
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        <property type="entry name" value="MYO15B_SH3"/>
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        <property type="entry name" value="MyTH4_dom"/>
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        <property type="entry name" value="MyTH4_dom_sf"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF16">
        <property type="entry name" value="MYOSIN XVB"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
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    </dbReference>
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        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MyTH4"/>
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    </dbReference>
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        <property type="entry name" value="Second domain of FERM"/>
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    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5035207160" description="Myosin XVB" evidence="9">
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            <begin position="20"/>
            <end position="1667"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="1339"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="594"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1632"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="644"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="701"/>
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    </feature>
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        <location>
            <begin position="718"/>
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        <location>
            <begin position="737"/>
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            <begin position="748"/>
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            <begin position="789"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050854.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1667" mass="183002" checksum="4C17FD4C3D1E7009" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8I5R1V4_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="175" mass="20144" checksum="DE8A5ABEDD801865" modified="2022-05-25" version="1">MRVPSLIQAQDNPHTLKPGTCCAALVPTSGWWTEAPGELERFLKRRLSTSLSADSDSVSERWGEELSRQEERHMQRTEGSLGWRQARKRVLSTSWSSLEPQPKDGATQEFLSKVRFLFCFVEMESRSVAQPGVQWRNLSSLQPLPPRFKQFSCLSLLRSWDYRCAPPHPANFYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2B7</accession>
    <name>A0A8I5R2B7_PAPAN</name>
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        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
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            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
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    <organism evidence="9 10">
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        <name type="common">Olive baboon</name>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009194324.1">
        <property type="nucleotide sequence ID" value="XM_009196060.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R2B7"/>
    <dbReference type="Ensembl" id="ENSPANT00000075590.1">
        <property type="protein sequence ID" value="ENSPANP00000058982.1"/>
        <property type="gene ID" value="ENSPANG00000049958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100999326"/>
    <dbReference type="KEGG" id="panu:100999326"/>
    <dbReference type="GeneTree" id="ENSGT00550000074698"/>
    <dbReference type="OMA" id="YSAHDHE"/>
    <dbReference type="OrthoDB" id="9631264at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="114" mass="11544" checksum="4C282AA51CA079C8" modified="2022-05-25" version="1">MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2C9</accession>
    <name>A0A8I5R2C9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R2C9"/>
    <dbReference type="Ensembl" id="ENSPANT00000076078.1">
        <property type="protein sequence ID" value="ENSPANP00000059126.1"/>
        <property type="gene ID" value="ENSPANG00000039020.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF133">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="178" mass="20107" checksum="8DBDD3353B08B076" modified="2022-05-25" version="1">VIQDIFLAVFKILLSVTFKNLLIYVFAINIFVCILVCLLSFFIFSFFLTFRIFGCNFFSFLSFFLLPFLSFPFLSLSFPPFPFLPLPSPPLPSPPLSFPFLSFFEMESRSVAQAGVQWHDLVSLQLPPPGFKQFSASASRVAGITGACHHAWLIFFFVFLVETGFHCVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R8G5</accession>
    <name>A0A8I5R8G5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A8I5R8G5"/>
    <dbReference type="Ensembl" id="ENSPANT00000078322.1">
        <property type="protein sequence ID" value="ENSPANP00000056156.1"/>
        <property type="gene ID" value="ENSPANG00000042293.1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
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    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12668:SF34">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="127"/>
            <end position="145"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="193" mass="21446" checksum="FBC4F7C2CC915F68" modified="2022-05-25" version="1">MPGACRYSAAQAPPPPSPFSALPSPRTLRRRHDAPPFSPPCRAPGTQRGRKRVSGETWLLCLAACARLWTARAFGRCRLGVVFLDREEKNGEEPLAISAFALVWLWLHSSGCFWWDRWLCKNRVASLAAGLLFGSLAGLGSYQMSQDPRNVWVFLAATSVTFVGVLGLRSYYYGKVMPFADGRQSWSSYVDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
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                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
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                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000051212.1"/>
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        <property type="entry name" value="Mucin-22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37000">
        <property type="entry name" value="MUCIN-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37000:SF3">
        <property type="entry name" value="MUCIN-22"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="587" mass="65509" checksum="6CB9E92D35A178C2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKL8</accession>
    <name>A0A096MKL8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
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        <name evidence="14" type="primary">UBE2A</name>
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    <organism evidence="14 15">
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096MKL8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000034"/>
    <dbReference type="Ensembl" id="ENSPANT00000005461.3">
        <property type="protein sequence ID" value="ENSPANP00000000034.3"/>
        <property type="gene ID" value="ENSPANG00000016113.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155075"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016113">
        <property type="expression patterns" value="Expressed in descending colon and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MKL8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000062">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="76"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000034.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="224" mass="24623" checksum="3F09000D5AD029DA" modified="2022-05-25" version="3">MWFQSQIVGSAPVYTGVVLSRRQTDPRLRRGSAVPLGASASPSPASSASSASSPAAGTRDPSVCPTPDPARDMSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKX0</accession>
    <name>A0A096MKX0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PNMA family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PNMA1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MKX0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000157"/>
    <dbReference type="Ensembl" id="ENSPANT00000007738.3">
        <property type="protein sequence ID" value="ENSPANP00000000157.2"/>
        <property type="gene ID" value="ENSPANG00000003663.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SPHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234522"/>
    <dbReference type="HOGENOM" id="CLU_014694_0_0_1"/>
    <dbReference type="OMA" id="EHTNEVM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003663">
        <property type="expression patterns" value="Expressed in mammillary body and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048271">
        <property type="entry name" value="PNMA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF17">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN MA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20846">
        <property type="entry name" value="PNMA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paraneoplastic antigen Ma-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Paraneoplastic antigen Ma-like C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000157.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="331" mass="37078" checksum="A461D0EB2FE061D3" modified="2022-05-25" version="2">MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEENAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPWLEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSVESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ML42</accession>
    <name>A0A096ML42_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Huntingtin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HTT</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in microtubule-mediated transport or vesicle function.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Promotes the formation of autophagic vesicles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with PFN1. Interacts through its N-terminus with PRPF40A. Interacts with PQBP1. Interacts with SETD2. Interacts with SH3GLB1. Interacts with SYVN. Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Interacts with F8A1/F8A2/F8A3. Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the huntingtin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021793897.2">
        <property type="nucleotide sequence ID" value="XM_021938205.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000007147.3">
        <property type="protein sequence ID" value="ENSPANP00000000238.3"/>
        <property type="gene ID" value="ENSPANG00000020180.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000758"/>
    <dbReference type="KEGG" id="panu:101000758"/>
    <dbReference type="CTD" id="3064"/>
    <dbReference type="eggNOG" id="ENOG502QR1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015863"/>
    <dbReference type="HOGENOM" id="CLU_243737_0_0_1"/>
    <dbReference type="OMA" id="PNKMEEP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020180">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096ML42">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016234">
        <property type="term" value="C:inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099524">
        <property type="term" value="C:postsynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099523">
        <property type="term" value="C:presynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905337">
        <property type="term" value="P:positive regulation of aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905291">
        <property type="term" value="P:positive regulation of CAMKK-AMPK signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904504">
        <property type="term" value="P:positive regulation of lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042297">
        <property type="term" value="P:vocal learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000273">
        <property type="entry name" value="Huntingtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000388">
        <property type="entry name" value="Huntingtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048412">
        <property type="entry name" value="Htt_bridge"/>
    </dbReference>
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        <property type="entry name" value="Htt_C-HEAT_rpt"/>
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        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
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    <dbReference type="InterPro" id="IPR000091">
        <property type="entry name" value="Huntingtin"/>
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        <property type="entry name" value="Huntingtin_fam"/>
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    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
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    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20925">
        <property type="entry name" value="Htt_bridge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00375">
        <property type="entry name" value="HUNTINGTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="509"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1168"/>
            <end position="1217"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2323"/>
            <end position="2342"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2626"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1199"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2626"/>
            <end position="2637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000238.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="3134" mass="346562" checksum="1DD8BA39B4B40A68" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLA3</accession>
    <name>A0A096MLA3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Angiopoietin like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ANGPTL1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003893517.1">
        <property type="nucleotide sequence ID" value="XM_003893468.5"/>
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    <dbReference type="RefSeq" id="XP_031514110.1">
        <property type="nucleotide sequence ID" value="XM_031658250.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A096MLA3"/>
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    <dbReference type="Ensembl" id="ENSPANT00000005831.3">
        <property type="protein sequence ID" value="ENSPANP00000000315.1"/>
        <property type="gene ID" value="ENSPANG00000017311.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004735"/>
    <dbReference type="KEGG" id="panu:101004735"/>
    <dbReference type="CTD" id="9068"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155091"/>
    <dbReference type="HOGENOM" id="CLU_038628_0_0_1"/>
    <dbReference type="OMA" id="CQHAKDA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017311">
        <property type="expression patterns" value="Expressed in optic disc and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FIB_ANG-like"/>
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        <property type="entry name" value="Fibrinogen-like_C"/>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
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    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
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        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
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    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
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    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="chain" id="PRO_5001920622" evidence="5">
        <location>
            <begin position="24"/>
            <end position="491"/>
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    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="271"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="491" mass="56686" checksum="DECCD3EA63BC92FD" modified="2014-11-26" version="1">MKAFTWTLGVLFFLLVDVGRCRGGQFKIKKINQRRYPRATDGKEEAKKCAYTFLVPEQRITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDTHVSPPLVQVVPQHIPNSHQYTPGLLGGNEIQRDPGYPRDLMPPPDLATSPTKSPFKIPPVTFINEGPFKDCQQAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNB3</accession>
    <name>A0A096MNB3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">OST4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908439.1">
        <property type="nucleotide sequence ID" value="XM_003908390.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNB3"/>
    <dbReference type="SMR" id="A0A096MNB3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001131"/>
    <dbReference type="Ensembl" id="ENSPANT00000024835.3">
        <property type="protein sequence ID" value="ENSPANP00000001131.1"/>
        <property type="gene ID" value="ENSPANG00000011316.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023566"/>
    <dbReference type="KEGG" id="panu:101023566"/>
    <dbReference type="CTD" id="100128731"/>
    <dbReference type="eggNOG" id="ENOG502SDSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016516"/>
    <dbReference type="HOGENOM" id="CLU_186352_2_0_1"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011316">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160226">
        <property type="term" value="C:oligosaccharyltransferase complex A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160227">
        <property type="term" value="C:oligosaccharyltransferase complex B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="37" mass="4193" checksum="AADA830EA2A3952C" modified="2014-11-26" version="1">MITDVQLAIFANMLGVSLFLLVVLYHYVAVNNPKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MP99</accession>
    <name>A0A096MP99_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PHKA2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13 15">Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cell membrane</location>
            <topology evidence="2 15">Lipid-anchor</topology>
            <orientation evidence="2 15">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="14">Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917522.1">
        <property type="nucleotide sequence ID" value="XM_003917473.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MP99"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001541"/>
    <dbReference type="Ensembl" id="ENSPANT00000014757.3">
        <property type="protein sequence ID" value="ENSPANP00000001541.1"/>
        <property type="gene ID" value="ENSPANG00000016122.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019637"/>
    <dbReference type="KEGG" id="panu:101019637"/>
    <dbReference type="CTD" id="5256"/>
    <dbReference type="eggNOG" id="KOG3635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183118"/>
    <dbReference type="HOGENOM" id="CLU_004177_1_0_1"/>
    <dbReference type="OMA" id="QFEHIEC"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
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        <property type="component" value="Chromosome X"/>
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    <dbReference type="Bgee" id="ENSPANG00000016122">
        <property type="expression patterns" value="Expressed in liver and 66 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A096MP99">
        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:phosphorylase kinase complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphorylase kinase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF5">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 15" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 14 15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="17">
        <location>
            <begin position="8"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="18">
        <location>
            <begin position="1063"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-farnesyl cysteine" evidence="14">
        <location>
            <position position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025890"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR608734-50"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138561" checksum="6D65ED5218EB0834" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPD9</accession>
    <name>A0A096MPD9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger and BTB domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZBTB3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MPD9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001592"/>
    <dbReference type="Ensembl" id="ENSPANT00000020750.3">
        <property type="protein sequence ID" value="ENSPANP00000001592.2"/>
        <property type="gene ID" value="ENSPANG00000008469.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161486"/>
    <dbReference type="HOGENOM" id="CLU_034521_0_0_1"/>
    <dbReference type="OMA" id="YPRGLVT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008469">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MPD9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18323">
        <property type="entry name" value="BTB_POZ_ZBTB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000114">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000021">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000892">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF19">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="472"/>
            <end position="499"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="500"/>
            <end position="528"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="276"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001592.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="574" mass="61727" checksum="378699383B32D8D0" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQS6</accession>
    <name>A0A096MQS6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ATP6V0D2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031525514.1">
        <property type="nucleotide sequence ID" value="XM_031669654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQS6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002110"/>
    <dbReference type="Ensembl" id="ENSPANT00000005942.3">
        <property type="protein sequence ID" value="ENSPANP00000002110.2"/>
        <property type="gene ID" value="ENSPANG00000022220.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997943"/>
    <dbReference type="KEGG" id="panu:100997943"/>
    <dbReference type="CTD" id="245972"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002200"/>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OMA" id="ETLFPTC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022220">
        <property type="expression patterns" value="Expressed in renal medulla and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQS6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002110.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="328" mass="38044" checksum="7DE8916CC6201952" modified="2022-05-25" version="2">MLKKLFVYAQNLTRIGFYLISDLKIHLQTTDYGNFLANQTNPLTVSKIDTEMRKRLCGEFEYFRNHSLEPLSTFLTYMTCSYMIDNVILLMNGALQKKSVKEILGKCHPLGRFTEMEAVNIAETPSDLFNAILIETPLAPFFQDCMSENALDELNIELLRNKLYKSYLEAFYKFCKNHGDVTADVMCPILEFEADRRAFIITLNSFGTELSKEDRETLYPTFGKLYPEGLRLLAQAEDFDQMKNVADHYGVYKPLFEAVGGSGGKTLEDVFYEHEVQMNVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAECISQRHRTKINSYIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MSK1</accession>
    <name>A0A096MSK1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protocadherin-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Vascular cadherin-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Vascular endothelial cadherin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PCDH12</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="25" key="2">
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        <scope>IDENTIFICATION</scope>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="16">Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Acts as a regulator of cell migration, probably via increasing cell-cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.</text>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTG1</accession>
    <name>A0A096MTG1_PAPAN</name>
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        <submittedName>
            <fullName evidence="6">Chromosome 3 open reading frame 33</fullName>
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        <name evidence="6" type="primary">C3orf33</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MTG1"/>
    <dbReference type="Ensembl" id="ENSPANT00000018621.3">
        <property type="protein sequence ID" value="ENSPANP00000003092.1"/>
        <property type="gene ID" value="ENSPANG00000011556.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101007983"/>
    <dbReference type="eggNOG" id="ENOG502QR9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004493"/>
    <dbReference type="HOGENOM" id="CLU_069834_0_0_1"/>
    <dbReference type="OMA" id="ETWKENM"/>
    <dbReference type="OrthoDB" id="6220511at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011556">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTG1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000024">
        <property type="entry name" value="Chromosome 3 C3orf33 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434:SF1">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="293" mass="33859" checksum="CCD32B5DF202E353" modified="2014-11-26" version="1">MAGQPAASGSQSPDRDGMEPNVVARISQWADDHLRLVRNISTGMAIVGIMLLLRSIRLTSKFTSASDIPVEFIRRNVKLRGRLRRITENGLEIEHIPITLPIIASMRKEPCGALLVKLAGVELTETGKAWLQKELKPSQLLWFQLLGKENSALFCYLLVNKGGYFSVNLNEEILRRGLGKTVLVKGLKYDSKIYWRVHRNLLKAELTALKKGEGIWKEDSEKESYLEKLKDSWRIWKKDSFLKTTGSDFNLKKESYYDKLRRTYEIWKDNMNNYSLILKFKELISRIHFRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTM4</accession>
    <name>A0A096MTM4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IPO7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003910292.1">
        <property type="nucleotide sequence ID" value="XM_003910243.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTM4"/>
    <dbReference type="SMR" id="A0A096MTM4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003165"/>
    <dbReference type="Ensembl" id="ENSPANT00000018897.3">
        <property type="protein sequence ID" value="ENSPANP00000003165.2"/>
        <property type="gene ID" value="ENSPANG00000017378.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101014349"/>
    <dbReference type="KEGG" id="panu:101014349"/>
    <dbReference type="CTD" id="10527"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154666"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017378">
        <property type="expression patterns" value="Expressed in gastrocnemius and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTM4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000053">
        <property type="entry name" value="Importin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF27">
        <property type="entry name" value="IMPORTIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="881"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003165.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1038" mass="119517" checksum="355237CA1DA2D313" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MV22</accession>
    <name>A0A096MV22_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-defensin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DEFB135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has antibacterial activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta-defensin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017817242.1">
        <property type="nucleotide sequence ID" value="XM_017961753.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MV22"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003695"/>
    <dbReference type="Ensembl" id="ENSPANT00000007010.3">
        <property type="protein sequence ID" value="ENSPANP00000003695.1"/>
        <property type="gene ID" value="ENSPANG00000005416.3"/>
    </dbReference>
    <dbReference type="GeneID" id="108587144"/>
    <dbReference type="KEGG" id="panu:108587144"/>
    <dbReference type="CTD" id="613209"/>
    <dbReference type="eggNOG" id="ENOG502TF02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064429"/>
    <dbReference type="HOGENOM" id="CLU_181906_3_0_1"/>
    <dbReference type="OMA" id="NTCWRTK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005416">
        <property type="expression patterns" value="Expressed in testis and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.360.10">
        <property type="entry name" value="Antimicrobial Peptide, Beta-defensin 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050544">
        <property type="entry name" value="Beta-defensin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025933">
        <property type="entry name" value="Beta_defensin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15001">
        <property type="entry name" value="BETA-DEFENSIN 123-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15001:SF10">
        <property type="entry name" value="BETA-DEFENSIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13841">
        <property type="entry name" value="Defensin_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4 9" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6 9" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005108087" description="Beta-defensin" evidence="9">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-defensin" evidence="10">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU231113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="76" mass="8662" checksum="AAEE748260EAB467" modified="2014-11-26" version="1">MATRSVLLALVVLDLLFYVPPGRSGPNIYIQKLFASCWRLRGSCRQKCLKKEEYHILCDTTRLCCVNPQHLPILTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWD1</accession>
    <name>A0A096MWD1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DARS1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003909218.1">
        <property type="nucleotide sequence ID" value="XM_003909169.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWD1"/>
    <dbReference type="SMR" id="A0A096MWD1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004187"/>
    <dbReference type="Ensembl" id="ENSPANT00000019838.3">
        <property type="protein sequence ID" value="ENSPANP00000004187.2"/>
        <property type="gene ID" value="ENSPANG00000008858.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020497"/>
    <dbReference type="KEGG" id="panu:101020497"/>
    <dbReference type="CTD" id="1615"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234618"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008858">
        <property type="expression patterns" value="Expressed in fundus of stomach and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000144">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="196"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004187.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="501" mass="57152" checksum="9AECE4F7CD0C8CD9" modified="2018-02-28" version="2">MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWM7</accession>
    <name>A0A096MWM7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="18">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">UCHL1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A096MWM7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004285"/>
    <dbReference type="MEROPS" id="C12.001"/>
    <dbReference type="Ensembl" id="ENSPANT00000007849.3">
        <property type="protein sequence ID" value="ENSPANP00000004285.3"/>
        <property type="gene ID" value="ENSPANG00000016830.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157306"/>
    <dbReference type="HOGENOM" id="CLU_054406_2_0_1"/>
    <dbReference type="OMA" id="CISNGEA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016830">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWM7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000004">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF19">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7 17 18" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 18" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8 17 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="20">
        <location>
            <begin position="122"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="17">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004285.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="343" mass="38186" checksum="C6F9FD16FCB422A5" modified="2022-05-25" version="3">MVERMGFQKLRPKLKTPSKGLLHTLKEHPPTNPVSTTTRLSHRRVRLQGLGARPYHSALRTGVSYPSGRDRPFPPRLVLPLLPLRRPHSASGRRFIAAAWAAPLAVFRLPWVISVGRAAKMQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEGTLLQDAAKVCREFTEREQGEVRFSAVALCKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWU5</accession>
    <name>A0A096MWU5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RAB10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasmic vesicle membrane</location>
            <topology evidence="16">Lipid-anchor</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_009182085.2">
        <property type="nucleotide sequence ID" value="XM_009183821.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWU5"/>
    <dbReference type="SMR" id="A0A096MWU5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004353"/>
    <dbReference type="Ensembl" id="ENSPANT00000010095.3">
        <property type="protein sequence ID" value="ENSPANP00000004353.1"/>
        <property type="gene ID" value="ENSPANG00000009860.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016609"/>
    <dbReference type="KEGG" id="panu:101016609"/>
    <dbReference type="CTD" id="10890"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156975"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="ENIRTWF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009860">
        <property type="expression patterns" value="Expressed in esophagus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032593">
        <property type="term" value="C:insulin-responsive compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097051">
        <property type="term" value="P:establishment of protein localization to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="200" mass="22541" checksum="7F02B8E8E46EE1E8" modified="2014-11-26" version="1">MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISSGGGVTGWKSKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MY43</accession>
    <name>A0A096MY43_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein axonemal intermediate chain 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DNAI7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MY43"/>
    <dbReference type="Ensembl" id="ENSPANT00000005163.3">
        <property type="protein sequence ID" value="ENSPANP00000004839.3"/>
        <property type="gene ID" value="ENSPANG00000003393.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004708"/>
    <dbReference type="HOGENOM" id="CLU_003945_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003393">
        <property type="expression patterns" value="Expressed in perirenal fat and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MY43">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022110">
        <property type="entry name" value="CASC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12366">
        <property type="entry name" value="Casc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15927">
        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02043">
        <property type="entry name" value="CANCERSCCP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CASC1 C-terminal" evidence="4">
        <location>
            <begin position="461"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004839.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="716" mass="83547" checksum="BC806F3B2B16B29C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYT8</accession>
    <name>A0A096MYT8_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">Small integral membrane protein 33</fullName>
        </submittedName>
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        <name evidence="3" type="primary">SMIM33</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
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                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
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                <person name="Rouhana J.R."/>
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                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Ensembl" id="ENSPANT00000026075.3">
        <property type="protein sequence ID" value="ENSPANP00000005109.2"/>
        <property type="gene ID" value="ENSPANG00000003457.3"/>
    </dbReference>
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    <dbReference type="OMA" id="HEDAQQE"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="expression patterns" value="Expressed in pancreas and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038803">
        <property type="entry name" value="SMIM33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37873">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37873:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005109.2"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="132" mass="14142" checksum="1E2E09964F72C108" modified="2018-02-28" version="2">MHQAGHYSWPSPAVNSSSGQESQRQLSEVLGGIWEQPRGDGLPMVTIIVAVFVLLAVCIIVAVHFGPRLHQGHATLPTEPLIPKPDGGIYLIHWRALGPQDSPEEALRGPLVPGSCSAPDGPRPSIDEVTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZY1</accession>
    <name>A0A096MZY1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Keratin associated protein 3-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KRTAP3-1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRTAP type 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MZY1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005539"/>
    <dbReference type="Ensembl" id="ENSPANT00000006984.3">
        <property type="protein sequence ID" value="ENSPANP00000005539.1"/>
        <property type="gene ID" value="ENSPANG00000002591.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:103878831"/>
    <dbReference type="eggNOG" id="KOG4726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001157"/>
    <dbReference type="HOGENOM" id="CLU_2359185_0_0_1"/>
    <dbReference type="OMA" id="NPCEPCC"/>
    <dbReference type="OrthoDB" id="9446518at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002591">
        <property type="expression patterns" value="Expressed in zone of skin and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007659">
        <property type="entry name" value="Keratin_matx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23260">
        <property type="entry name" value="KERATIN ASSOCIATED PROTEIN 3-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23260:SF3">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 3-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04579">
        <property type="entry name" value="Keratin_matx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0416">Keratin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="98" mass="10491" checksum="496DAF3896603967" modified="2014-11-26" version="1">MDCCALRSCSVPTGPATTFCSFDKSCRCGVCLPSTCPHEISLLQPICCDTCPPPCCKPDTYVPTCWLLNNCHPTPGLSGINLTTYVQPGCESPCEPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N032</accession>
    <name>A0A096N032_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein U-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HNRNPUL2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds to MLF1 and retains it in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003909734.1">
        <property type="nucleotide sequence ID" value="XM_003909685.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N032"/>
    <dbReference type="SMR" id="A0A096N032"/>
    <dbReference type="Ensembl" id="ENSPANT00000012782.4">
        <property type="protein sequence ID" value="ENSPANP00000005596.3"/>
        <property type="gene ID" value="ENSPANG00000023745.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101008447"/>
    <dbReference type="KEGG" id="panu:101008447"/>
    <dbReference type="CTD" id="221092"/>
    <dbReference type="GeneTree" id="ENSGT00940000160376"/>
    <dbReference type="HOGENOM" id="CLU_012140_1_0_1"/>
    <dbReference type="OMA" id="DSRGLKM"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023745">
        <property type="expression patterns" value="Expressed in cornea and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N032">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000006">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000355">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein U-like 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000017">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein U-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <begin position="40"/>
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            <begin position="73"/>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N427</accession>
    <name>A0A096N427_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Myotubularin related protein 14</fullName>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
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                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
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                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
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                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
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                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
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                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
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                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
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                <person name="Hogues M.H."/>
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                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="CYSTEINE-RICH TAIL PROTEIN 1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="189" mass="20250" checksum="BEE73ADD0834C52A" modified="2022-05-25" version="3">IAPPLSLSPAPRREKAAASRSTQALGPRAQKTKRTDCHAATTGWTMDPQEMVVKNPYAHISIPRAHLRPDLGQQLEVASPCSSSSEMQPLPVGPCAPEPTRLLQPTEVPGPKGTKGDQRAAPIQNHQAWQQPGNPYNSSQRPAGLTYAGPPPVGRGDDIAHHCCCCPCCRCCHCPPFCRCHSCCCCVIS</sequence>
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    <accession>A0A096N8P7</accession>
    <name>A0A096N8P7_PAPAN</name>
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        <submittedName>
            <fullName evidence="16">Extracellular leucine rich repeat and fibronectin type III domain containing 1</fullName>
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        <name evidence="16" type="primary">ELFN1</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with PPP1CA.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="gene ID" value="ENSPANG00000005921.3"/>
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    <dbReference type="KEGG" id="panu:101007876"/>
    <dbReference type="CTD" id="392617"/>
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    <dbReference type="GeneTree" id="ENSGT00940000161391"/>
    <dbReference type="HOGENOM" id="CLU_018770_0_0_1"/>
    <dbReference type="OMA" id="TCELYSN"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="expression patterns" value="Expressed in amygdala and 5 other cell types or tissues"/>
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        <property type="term" value="C:axon terminus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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        <property type="entry name" value="Fn3_ELFN"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008978.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="828" mass="90361" checksum="E2B6BBFA981C6470" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N993</accession>
    <name>A0A096N993_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kelch-like protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KLHL20</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1. Interacts with PDZ-RhoGEF/ARHGEF11, DAPK1, PML and CORO7. Interacts with F-actin. Interacts with IFN-gamma (IFNG). Interacts (via kelch repeats) with IVNS1ABP (via kelch repeats); this interaction blocks the assembly of CUL3-KLHL20 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N993"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009199"/>
    <dbReference type="Ensembl" id="ENSPANT00000023647.3">
        <property type="protein sequence ID" value="ENSPANP00000009199.3"/>
        <property type="gene ID" value="ENSPANG00000008914.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155161"/>
    <dbReference type="HOGENOM" id="CLU_004253_14_2_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008914">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N993">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019964">
        <property type="term" value="F:type II interferon binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990390">
        <property type="term" value="P:protein K33-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18459">
        <property type="entry name" value="BACK_KLHL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18249">
        <property type="entry name" value="BTB_POZ_KLHL20_KLEIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000006">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF451">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009199.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="605" mass="67456" checksum="A00BE1B9275AB9E4" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDB6</accession>
    <name>A0A096NDB6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vesicle-trafficking protein SEC22a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">SEC22 vesicle-trafficking protein homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SEC22A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vesicle transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894069.1">
        <property type="nucleotide sequence ID" value="XM_003894020.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009198384.1">
        <property type="nucleotide sequence ID" value="XM_009200120.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009198385.1">
        <property type="nucleotide sequence ID" value="XM_009200121.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810700.1">
        <property type="nucleotide sequence ID" value="XM_017955211.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810701.1">
        <property type="nucleotide sequence ID" value="XM_017955212.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810702.1">
        <property type="nucleotide sequence ID" value="XM_017955213.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDB6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010860"/>
    <dbReference type="Ensembl" id="ENSPANT00000004989.3">
        <property type="protein sequence ID" value="ENSPANP00000010860.1"/>
        <property type="gene ID" value="ENSPANG00000007784.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014003"/>
    <dbReference type="KEGG" id="panu:101014003"/>
    <dbReference type="CTD" id="26984"/>
    <dbReference type="eggNOG" id="KOG0862">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158470"/>
    <dbReference type="HOGENOM" id="CLU_054453_0_0_1"/>
    <dbReference type="OMA" id="NTGMQEC"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007784">
        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDB6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000010">
        <property type="entry name" value="vesicle-trafficking protein SEC22a isoform X2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059071">
        <property type="entry name" value="SEC22a-c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043546">
        <property type="entry name" value="Sec22a/c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46258">
        <property type="entry name" value="LONGIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46258:SF3">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25970">
        <property type="entry name" value="SEC22a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="307" mass="34906" checksum="9019565840FC2777" modified="2014-11-26" version="1">MSMILSASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTDSYPNVLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRTKQRYNNPRSLSTKINLSDMQTEIKLRPPYQISMCELGSANGVTSAFSVDCKGAGKISSAHQRLEPATLSGIVGFILSLLCGALNLIRGFHAIESLLQSDGDDFNYIIAFFLGTAACLYQCYLLVYYTGWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQIWLRQAQGKAPDYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDN5</accession>
    <name>A0A096NDN5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Popeye domain cAMP effector 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">POPDC3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the popeye family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898010.1">
        <property type="nucleotide sequence ID" value="XM_003897961.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813658.1">
        <property type="nucleotide sequence ID" value="XM_017958169.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDN5"/>
    <dbReference type="SMR" id="A0A096NDN5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010982"/>
    <dbReference type="Ensembl" id="ENSPANT00000000525.3">
        <property type="protein sequence ID" value="ENSPANP00000010982.1"/>
        <property type="gene ID" value="ENSPANG00000010757.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008366"/>
    <dbReference type="KEGG" id="panu:101008366"/>
    <dbReference type="CTD" id="64208"/>
    <dbReference type="eggNOG" id="ENOG502QWBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002563"/>
    <dbReference type="HOGENOM" id="CLU_048494_2_1_1"/>
    <dbReference type="OMA" id="TSWKQEA"/>
    <dbReference type="OrthoDB" id="425611at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010757">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF18">
        <property type="entry name" value="POPEYE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="7">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="291" mass="33898" checksum="1F3E08CC6DB61B3E" modified="2014-11-26" version="1">MERNSTLWKNLIDEHPVCTTWKQEAEGAIYHLASILFVVGFMGGSGFFGLLYVFSLLGLGFLCSAVWAWVDVCAADIFSWNFVLFVICFMQFVHIAYQVRSITFAREFQVLYSSLFQPLGISLPVFRTIALSSEVVTLEKEHCYAMQGKTSIDKLSLLVSGRIRVTVDGEFLHYIFPLQFLDSPEWDSLRPTEEGIFQVTLTAETDCRYVSWRRKKLYLLFAQHRYISRLFSVLIGSDIADKLYALNDRVYIGKRYHYDIRLPNFYQMSSPEIRRSPLTQHFRNSRRYCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NF43</accession>
    <name>A0A096NF43_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADPH oxidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NOX3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NF43"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011531"/>
    <dbReference type="Ensembl" id="ENSPANT00000021375.3">
        <property type="protein sequence ID" value="ENSPANP00000011531.2"/>
        <property type="gene ID" value="ENSPANG00000022192.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160501"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_1_1"/>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022192">
        <property type="expression patterns" value="Expressed in fundus of stomach and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009590">
        <property type="term" value="P:detection of gravity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048840">
        <property type="term" value="P:otolith development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001659">
        <property type="term" value="P:temperature homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000030">
        <property type="entry name" value="cytochrome b-245 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF12">
        <property type="entry name" value="NADPH OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="568" mass="64877" checksum="1E2B8B96CAA2076D" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NG36</accession>
    <name>A0A096NG36_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BNIPL</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009179093.1">
        <property type="nucleotide sequence ID" value="XM_009180829.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017802525.1">
        <property type="nucleotide sequence ID" value="XM_017947036.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NG36"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011898"/>
    <dbReference type="Ensembl" id="ENSPANT00000025706.3">
        <property type="protein sequence ID" value="ENSPANP00000011898.2"/>
        <property type="gene ID" value="ENSPANG00000005713.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998322"/>
    <dbReference type="KEGG" id="panu:100998322"/>
    <dbReference type="CTD" id="149428"/>
    <dbReference type="eggNOG" id="ENOG502QUPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161723"/>
    <dbReference type="HOGENOM" id="CLU_039135_1_0_1"/>
    <dbReference type="OMA" id="NYPYIME"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005713">
        <property type="expression patterns" value="Expressed in esophagus and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040009">
        <property type="term" value="P:regulation of growth rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000012">
        <property type="entry name" value="bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF21">
        <property type="entry name" value="BCL-2_ADENOVIRUS E1B 19 KDA-INTERACTING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="109"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00065286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011898.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="275" mass="30901" checksum="4D5166E28801B386" modified="2022-05-25" version="2">MRKRLSAPELRLSLTKGPGNDGASPTQSTPSSPDGSSDLEVDELETPSDSEQLDSGHEFEWEDELPRAEGLGASEAAERLGRGCMWDVAGEDGRHWRVFRIGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NKW8</accession>
    <name>A0A096NKW8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="14">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NME3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor. The ATP gamma phosphate is transferred to the nucleoside diphosphate beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Inhibits granulocyte differentiation. May be required for ciliary function during renal development.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Independently of its kinase activity, facilitates mitochondrial tethering prior to membrane fusion through its direct membrane-binding and hexamerization. Implicated in repair of both single- and double-stranded breaks in DNA through its association with the ribonucleotide reductase complex (RNR complex) via its interaction with the histone acetyltransferase KAT5, this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA, independently of its kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:44641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18114"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer. Interacts (via its N-terminal region) with KAT5; this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA. Found in association with several ciliary nephronophthisis proteins, including NEK8, CEP164, ANKS6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="14"/>
    <dbReference type="RefSeq" id="XP_003916397.1">
        <property type="nucleotide sequence ID" value="XM_003916348.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NKW8"/>
    <dbReference type="SMR" id="A0A096NKW8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013625"/>
    <dbReference type="Ensembl" id="ENSPANT00000000972.3">
        <property type="protein sequence ID" value="ENSPANP00000013625.1"/>
        <property type="gene ID" value="ENSPANG00000017598.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018324"/>
    <dbReference type="KEGG" id="panu:101018324"/>
    <dbReference type="CTD" id="4832"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161283"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="OMA" id="ACAGVHE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017598">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160204">
        <property type="term" value="F:mitochondrion-mitochondrion outer membrane tether activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001928336" description="Nucleoside diphosphate kinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="16">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="169" mass="19015" checksum="CCA41A122A37202D" modified="2014-11-26" version="1">MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NM86</accession>
    <name>A0A096NM86_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003901052.1">
        <property type="nucleotide sequence ID" value="XM_003901003.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NM86"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014095"/>
    <dbReference type="Ensembl" id="ENSPANT00000011738.3">
        <property type="protein sequence ID" value="ENSPANP00000014095.2"/>
        <property type="gene ID" value="ENSPANG00000017199.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000066300.1">
        <property type="protein sequence ID" value="ENSPANP00000047904.1"/>
        <property type="gene ID" value="ENSPANG00000039003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100999817"/>
    <dbReference type="KEGG" id="panu:100999817"/>
    <dbReference type="eggNOG" id="ENOG502QUXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158531"/>
    <dbReference type="HOGENOM" id="CLU_039135_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017199">
        <property type="expression patterns" value="Expressed in zone of skin and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NM86">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000001">
        <property type="entry name" value="BCL2/adenovirus E1B protein-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF12">
        <property type="entry name" value="BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="264"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014095.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="431" mass="48164" checksum="09EA4CA53861627B" modified="2018-02-28" version="2">MPCGFQEDATPPPPPPRLRLPRPEEAGMLSLPPGPLTASGSAVAAAAVPLRPRDWAGVSTAERGERAPLGAAFCDLAVSPTSPAWRGEEDEGAKASSGDIGSLDYQEFVVDIESRLRMEGVELKEEWQDEDFPIPLPEDDSIEADILAITGPEDQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDGLDTPSENSNEFEWEDDLPKPKTTEVIRKGSIAEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESSQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQVDQELNGKQDEPKSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNC3</accession>
    <name>A0A096NNC3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901472.1">
        <property type="nucleotide sequence ID" value="XM_003901423.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031524169.1">
        <property type="nucleotide sequence ID" value="XM_031668309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNC3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014483"/>
    <dbReference type="Ensembl" id="ENSPANT00000006653.3">
        <property type="protein sequence ID" value="ENSPANP00000014483.1"/>
        <property type="gene ID" value="ENSPANG00000020922.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000067911.1">
        <property type="protein sequence ID" value="ENSPANP00000058539.1"/>
        <property type="gene ID" value="ENSPANG00000039683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100997457"/>
    <dbReference type="GeneID" id="116275757"/>
    <dbReference type="KEGG" id="panu:100997457"/>
    <dbReference type="CTD" id="91947"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160523"/>
    <dbReference type="HOGENOM" id="CLU_039221_1_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020922">
        <property type="expression patterns" value="Expressed in urinary bladder and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000005">
        <property type="entry name" value="Arrestin domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000007">
        <property type="entry name" value="Arrestin domain-containing protein 3 mRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF16">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="8">
        <location>
            <begin position="191"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="418" mass="45356" checksum="AD5CE285AE75A8B2" modified="2014-11-26" version="1">MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSAGPCASASASALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPSYPQPPNCEGEVCCPMFACIQEFRFQPPPLYAEVDPHPSDVEETQPVSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPG9</accession>
    <name>A0A096NPG9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CHMP3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908985.2">
        <property type="nucleotide sequence ID" value="XM_003908936.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NPG9"/>
    <dbReference type="Ensembl" id="ENSPANT00000016357.3">
        <property type="protein sequence ID" value="ENSPANP00000014899.3"/>
        <property type="gene ID" value="ENSPANG00000021184.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000776"/>
    <dbReference type="KEGG" id="panu:101000776"/>
    <dbReference type="CTD" id="51652"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182832"/>
    <dbReference type="HOGENOM" id="CLU_069208_0_1_1"/>
    <dbReference type="OMA" id="KILWEVT"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021184">
        <property type="expression patterns" value="Expressed in prostate gland and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NPG9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904930">
        <property type="term" value="C:amphisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990381">
        <property type="term" value="F:ubiquitin-specific protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061763">
        <property type="term" value="P:multivesicular body-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044790">
        <property type="term" value="P:suppression of viral release by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046761">
        <property type="term" value="P:viral budding from plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014899.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="290" mass="32462" checksum="0C86138970B099EE" modified="2022-05-25" version="3">MTSALLTSIPLTQFCACVQRMRTILYCCRSLLWASALPPSPWAPPRRLPVTCLGAGNGKPEGARRVQFVMGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCVVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGKAPSKVTDALPEPEPSGAMAASDEEEEEEALEAMQSRLATLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ94</accession>
    <name>A0A096NQ94_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">WD repeat-containing protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">WDR35</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, ITF43 and TTC21B. Interacts with IFT43. Interacts with CFAP61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Cytoskeleton</location>
            <location evidence="12">Microtubule organizing center</location>
            <location evidence="12">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Cytoskeleton</location>
            <location evidence="12">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009182005.1">
        <property type="nucleotide sequence ID" value="XM_009183741.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182006.1">
        <property type="nucleotide sequence ID" value="XM_009183742.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQ94"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015188"/>
    <dbReference type="Ensembl" id="ENSPANT00000022382.3">
        <property type="protein sequence ID" value="ENSPANP00000015188.2"/>
        <property type="gene ID" value="ENSPANG00000019305.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018979"/>
    <dbReference type="CTD" id="57539"/>
    <dbReference type="eggNOG" id="KOG2041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155745"/>
    <dbReference type="HOGENOM" id="CLU_004048_1_0_1"/>
    <dbReference type="OMA" id="VWAMCWA"/>
    <dbReference type="OrthoDB" id="10260567at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019305">
        <property type="expression patterns" value="Expressed in mammillary body and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQ94">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000004">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000187">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017233">
        <property type="entry name" value="WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037536">
        <property type="entry name" value="WD_repeat_p35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 12" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 12" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="16">
        <location>
            <begin position="337"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="15">
        <location>
            <begin position="698"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="18">
        <location>
            <begin position="1021"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="14">
        <location>
            <begin position="1138"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015188.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1181" mass="133617" checksum="FBE093B9AE14278B" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQE3</accession>
    <name>A0A096NQE3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ArfGAP with dual PH domains 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQE3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015237"/>
    <dbReference type="Ensembl" id="ENSPANT00000017215.4">
        <property type="protein sequence ID" value="ENSPANP00000015237.2"/>
        <property type="gene ID" value="ENSPANG00000021960.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155698"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021960">
        <property type="expression patterns" value="Expressed in amygdala and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQE3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043533">
        <property type="term" value="F:inositol 1,3,4,5 tetrakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000011">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF5">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="10">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="139"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="262"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015237.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="44766" checksum="5842D5F1B527B584" modified="2018-02-28" version="2">MFQFVFSRAYCTNSIRRKWKEFEKTLGCAEEGHPSLGDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWDEAQVEFLASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQK7</accession>
    <name>A0A096NQK7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Target of EGR1 protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TOE1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with U1, U2, U4, U5 and U6 snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891838.1">
        <property type="nucleotide sequence ID" value="XM_003891789.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQK7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015317"/>
    <dbReference type="Ensembl" id="ENSPANT00000021289.3">
        <property type="protein sequence ID" value="ENSPANP00000015317.3"/>
        <property type="gene ID" value="ENSPANG00000012549.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997383"/>
    <dbReference type="KEGG" id="panu:100997383"/>
    <dbReference type="CTD" id="114034"/>
    <dbReference type="eggNOG" id="KOG1990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153167"/>
    <dbReference type="HOGENOM" id="CLU_044804_1_0_1"/>
    <dbReference type="OMA" id="RCCMPPT"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012549">
        <property type="expression patterns" value="Expressed in descending colon and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000039">
        <property type="entry name" value="Target of EGR1 protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF37">
        <property type="entry name" value="TARGET OF EGR1 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="332"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015317.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="509" mass="56306" checksum="9CC25BFE03A32CF9" modified="2022-05-25" version="3">MAAYSDDGAASAPAASDGGVSKSTTSGEELVVRVPVVDVQSNNFKEMWPSLLLAIKTANFVAVDTELSGLGDRKSLLNQCIEERYKAVCHAARTRSILSLGLACFKRQPDKGEHSYLAQVFNLTLLCMEEYVIEPKSVQFLIQHGFNFNQQYAQGIPYHKGNDKGDESQSQSVRTLFLELIRARRPLVLHNGLIDLVFLYQNFYAHLPESLGTFTADLCEMFPAGIYDTKYAAEFHARFVASYLEYAFRKCERENGKQRAAGSPHLTLEFCNYPSSMRDHIDYRCCLPPATHRPHPTSICDNFSAYGWCPLGPQCPQSHDIDLIIDTDEAAAEDKRRRRRRREKRKRALLNLAGTQTSGEAKDGPPKKQVCGDSLKAEETEEVAENETRNLPHSNQGNKNDLEMGVTAARPEIADTATSEVPGSQASSNPVPGDGLHRAGFDAFMTGYVMAYVEVSQGPQPSSSGPWLPECHNKVYLSGKAVPLTVAKSQFSRSSKAHNQKMKLAWGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQY0</accession>
    <name>A0A096NQY0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly factor COX18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COX18</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQY0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015444"/>
    <dbReference type="Ensembl" id="ENSPANT00000006169.3">
        <property type="protein sequence ID" value="ENSPANP00000015444.1"/>
        <property type="gene ID" value="ENSPANG00000013331.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101000710"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063506"/>
    <dbReference type="HOGENOM" id="CLU_029282_2_2_1"/>
    <dbReference type="OMA" id="AMARQKF"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013331">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="334" mass="36963" checksum="5582F51850CFA002" modified="2014-11-26" version="1">MLCRLGGRWLRPLPALQLRARDPALAPVPTSGAKRPTPSVWAVAPVCAVHANGWYEALAASSPVRVAEEVLLGVQATTGLPWWGSILLSTVALRGAVTLPLAAYQHYILAKVENLQPEIKAIARHLNQEVVVRANQLGWSERVARLTYLKNMKRIISELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLSTGAAHSEAGFSVQEQLATGGILWFPDLTAPDSTWILPISVGVINLLIVEISALQKIGISRLQTYVTYFVRAMSVLMIPVAATVPSSIVLYWLCSSFMGLSQNLLLRSPGFRQLCRIPSTKSDSETPYKDIFAAFNTKFISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTC2</accession>
    <name>A0A096NTC2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ENDOV</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NTC2"/>
    <dbReference type="Ensembl" id="ENSPANT00000023295.3">
        <property type="protein sequence ID" value="ENSPANP00000016293.3"/>
        <property type="gene ID" value="ENSPANG00000019621.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011880"/>
    <dbReference type="HOGENOM" id="CLU_047631_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019621">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NTC2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016293.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="263" mass="28813" checksum="D7518F5D4CBAF117" modified="2022-05-25" version="3">MAQEAAEWPPEETLSLWKREQAQLKARVVDRDTEAWQRDPAFSGLRRVGGVDVSFVKGDSVRACASLVVLSYPELEVLLVDGNGVLHHRGFGVACHLGVLTDLPCVGVAKKLLQVDGLENNALHKEKIRLLQTRGDSFPLLGDSGTVLGMALRSHDRSTRPLYISVGHKMSLEAAVRLTCCCCRFRIPEPVRQADICSREHIRKSLGLPRPPTPRSPTQRPVACPRGDSGESSGEGQPPQDHSPGPRTAPRPGSQEQEGKDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NW03</accession>
    <name>A0A096NW03_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial assembly of ribosomal large subunit protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MALSU1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896250.1">
        <property type="nucleotide sequence ID" value="XM_003896201.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NW03"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017228"/>
    <dbReference type="Ensembl" id="ENSPANT00000016072.3">
        <property type="protein sequence ID" value="ENSPANP00000017228.1"/>
        <property type="gene ID" value="ENSPANG00000016790.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004410"/>
    <dbReference type="KEGG" id="panu:101004410"/>
    <dbReference type="CTD" id="115416"/>
    <dbReference type="eggNOG" id="KOG3212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015035"/>
    <dbReference type="HOGENOM" id="CLU_1277285_0_0_1"/>
    <dbReference type="OMA" id="HLKCKHD"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016790">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140978">
        <property type="term" value="F:mitochondrial large ribosomal subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070130">
        <property type="term" value="P:negative regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001929253" description="Mitochondrial assembly of ribosomal large subunit protein 1" evidence="7">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="235" mass="26399" checksum="D91749B3B49EEB64" modified="2014-11-26" version="1">MGLSGCVARLLAPLMWRRAVSSVAGCAVGAEPGLQLLAMQRLPVGAAFCRACQTPNFVRGLHSEPGLEERAERTVDEGRPESDAADHTGPKFDIDIMVSLLRQENARDICVIQVPPEMRYTDYFVIGSGTSTRHLHAMAFYIVKMYKHLKCKHDPHVKIEGKDTDDWMCVDFGSMVIHLMLPETREIYELEKLWTLRSYDDQLAQIAPETVPEDFILGIEEDDTSSVTPVEFKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXM7</accession>
    <accession>A0A096N128</accession>
    <name>A0A096NXM7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rabenosyn, RAB effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RBSN</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003906914.1">
        <property type="nucleotide sequence ID" value="XM_003906865.5"/>
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    <dbReference type="RefSeq" id="XP_017801541.1">
        <property type="nucleotide sequence ID" value="XM_017946052.3"/>
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    <dbReference type="RefSeq" id="XP_017801542.1">
        <property type="nucleotide sequence ID" value="XM_017946053.3"/>
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        <property type="nucleotide sequence ID" value="XM_017946054.2"/>
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    <dbReference type="RefSeq" id="XP_017801545.1">
        <property type="nucleotide sequence ID" value="XM_017946056.3"/>
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    <dbReference type="RefSeq" id="XP_017801546.1">
        <property type="nucleotide sequence ID" value="XM_017946057.3"/>
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    <dbReference type="RefSeq" id="XP_017801547.1">
        <property type="nucleotide sequence ID" value="XM_017946058.3"/>
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    <dbReference type="RefSeq" id="XP_017801548.1">
        <property type="nucleotide sequence ID" value="XM_017946059.2"/>
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    <dbReference type="RefSeq" id="XP_017801549.1">
        <property type="nucleotide sequence ID" value="XM_017946060.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A096NXM7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005970"/>
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        <property type="protein sequence ID" value="ENSPANP00000017828.1"/>
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    <dbReference type="GeneID" id="101014208"/>
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    <dbReference type="Proteomes" id="UP000028761">
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        <property type="expression patterns" value="Expressed in thymus and 68 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd15716">
        <property type="entry name" value="FYVE_RBNS5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="rabenosyn-5 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="4.10.860.20:FF:000003">
        <property type="entry name" value="rabenosyn-5 isoform X1"/>
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    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
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    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
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    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16601">
        <property type="entry name" value="NPF"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="785" mass="88969" checksum="0CAAB414CC25EC55" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0M0</accession>
    <name>A0A096P0M0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Steroidogenic factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Nuclear receptor subfamily 5 group A member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">NR5A1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021782851.1">
        <property type="nucleotide sequence ID" value="XM_021927159.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021782852.1">
        <property type="nucleotide sequence ID" value="XM_021927160.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021782853.1">
        <property type="nucleotide sequence ID" value="XM_021927161.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510360.1">
        <property type="nucleotide sequence ID" value="XM_031654500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P0M0"/>
    <dbReference type="SMR" id="A0A096P0M0"/>
    <dbReference type="Ensembl" id="ENSPANT00000027864.3">
        <property type="protein sequence ID" value="ENSPANP00000018895.2"/>
        <property type="gene ID" value="ENSPANG00000025862.3"/>
    </dbReference>
    <dbReference type="GeneID" id="110740403"/>
    <dbReference type="KEGG" id="panu:110740403"/>
    <dbReference type="CTD" id="2516"/>
    <dbReference type="eggNOG" id="KOG4218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153391"/>
    <dbReference type="HOGENOM" id="CLU_011437_0_0_1"/>
    <dbReference type="OMA" id="YPYPEVY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025862">
        <property type="expression patterns" value="Expressed in adrenal medulla and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P0M0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="Retinoid X Receptor"/>
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        <location>
            <begin position="10"/>
            <end position="85"/>
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            <begin position="126"/>
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        <location>
            <begin position="341"/>
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        <ligand>
            <name>a phospholipid derivative</name>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="461" mass="51652" checksum="580A4608392D14E1" modified="2018-02-28" version="2">MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHAPEPKGLAAGPPTGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVAAQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHTLVKEAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1H7</accession>
    <name>A0A096P1H7_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000025235.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00410000028916"/>
    <dbReference type="HOGENOM" id="CLU_176670_0_0_1"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in supraoptic nucleus and 9 other cell types or tissues"/>
    </dbReference>
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        <property type="entry name" value="DUF5540"/>
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    <dbReference type="Pfam" id="PF17694">
        <property type="entry name" value="DUF5540"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019202.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="108" mass="11883" checksum="6F578603A51C5D03" modified="2022-05-25" version="3">MELNTNIKSKKGVGRRNLKPMNGAWPPARGETACFQRTKEREEERCSLNIYYVRTITQGTAPACVGKRMQPSPTGKGGKCCTVHGLTRKIHNVQPNLQSPILSAACVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2W9</accession>
    <name>A0A096P2W9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Recoverin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RCVRN</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912387.1">
        <property type="nucleotide sequence ID" value="XM_003912338.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2W9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019694"/>
    <dbReference type="Ensembl" id="ENSPANT00000022908.3">
        <property type="protein sequence ID" value="ENSPANP00000019694.1"/>
        <property type="gene ID" value="ENSPANG00000023754.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006039"/>
    <dbReference type="KEGG" id="panu:101006039"/>
    <dbReference type="CTD" id="5957"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159441"/>
    <dbReference type="HOGENOM" id="CLU_072366_1_0_1"/>
    <dbReference type="OMA" id="WEFFGKK"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023754">
        <property type="expression patterns" value="Expressed in retina and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051924">
        <property type="term" value="P:regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF20">
        <property type="entry name" value="RECOVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0844">Vision</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="200" mass="23166" checksum="102A20D6FE273D14" modified="2014-11-26" version="1">MGNSKSGALSKEILEELQLNTKFSEEELSSWYQSFLRDCPSGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPEDENTPEKRAEKIWKYFGKRDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P318</accession>
    <name>A0A096P318_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">MED9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912452.1">
        <property type="nucleotide sequence ID" value="XM_003912403.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P318"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019743"/>
    <dbReference type="Ensembl" id="ENSPANT00000022571.3">
        <property type="protein sequence ID" value="ENSPANP00000019743.1"/>
        <property type="gene ID" value="ENSPANG00000023700.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010441"/>
    <dbReference type="KEGG" id="panu:101010441"/>
    <dbReference type="CTD" id="55090"/>
    <dbReference type="eggNOG" id="ENOG502S51J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017379"/>
    <dbReference type="HOGENOM" id="CLU_148111_0_0_1"/>
    <dbReference type="OMA" id="TMPGIQL"/>
    <dbReference type="OrthoDB" id="5950777at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023700">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P318">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21431">
        <property type="entry name" value="Med9-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039242">
        <property type="entry name" value="MED9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="146" mass="16392" checksum="0EE93BDC67E46E08" modified="2014-11-26" version="1">MASAGVAAGRQTEDALPPTSDQPLPDTKPLPPPQPPPVPAPQPQQSPAPRPQSPARAREEENYSFLPLVHSIIKCMDKDSPEVHQDLNALKTKFQEMRKLISTMPGIHLSPEQQQQQLQSLREQVRTKNELLQKYKSLCMFEIPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P395</accession>
    <name>A0A096P395_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box N1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FOXN1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021784549.1">
        <property type="nucleotide sequence ID" value="XM_021928857.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P395"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019820"/>
    <dbReference type="Ensembl" id="ENSPANT00000021931.3">
        <property type="protein sequence ID" value="ENSPANP00000019820.1"/>
        <property type="gene ID" value="ENSPANG00000023451.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025454"/>
    <dbReference type="CTD" id="8456"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158029"/>
    <dbReference type="HOGENOM" id="CLU_031768_1_0_1"/>
    <dbReference type="OMA" id="PSCGMKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023451">
        <property type="expression patterns" value="Expressed in zone of skin and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048514">
        <property type="term" value="P:blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001942">
        <property type="term" value="P:hair follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097535">
        <property type="term" value="P:lymphoid lineage cell migration into thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035878">
        <property type="term" value="P:nail development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030858">
        <property type="term" value="P:positive regulation of epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051798">
        <property type="term" value="P:positive regulation of hair follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902232">
        <property type="term" value="P:regulation of positive thymic T cell selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002360">
        <property type="term" value="P:T cell lineage commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097536">
        <property type="term" value="P:thymus epithelium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20056">
        <property type="entry name" value="FH_FOXN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000122">
        <property type="entry name" value="Forkhead box protein N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047401">
        <property type="entry name" value="FH_FOXN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049624">
        <property type="entry name" value="FOXN1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46721">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46721:SF1">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="271"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="271"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="648" mass="68897" checksum="22DE4B3BC2BD7FC1" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3T7</accession>
    <name>A0A096P3T7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">All trans-polyprenyl-diphosphate synthase PDSS1</fullName>
            <ecNumber evidence="16">2.5.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">All-trans-decaprenyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Decaprenyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Solanesyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Trans-prenyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PDSS1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:55364"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:55365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>7 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27802"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27803"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotetramer composed of 2 PDSS1/DPS1 and 2 PDSS2/DLP1 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.91" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003903528.1">
        <property type="nucleotide sequence ID" value="XM_003903479.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P3T7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020012"/>
    <dbReference type="Ensembl" id="ENSPANT00000020964.3">
        <property type="protein sequence ID" value="ENSPANP00000020012.2"/>
        <property type="gene ID" value="ENSPANG00000023036.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008173"/>
    <dbReference type="KEGG" id="panu:101008173"/>
    <dbReference type="CTD" id="23590"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153498"/>
    <dbReference type="HOGENOM" id="CLU_014015_1_2_1"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023036">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032478">
        <property type="term" value="C:heterotetrameric polyprenyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110142">
        <property type="term" value="C:ubiquinone biosynthesis complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097269">
        <property type="term" value="F:all-trans-decaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052923">
        <property type="term" value="F:all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000011">
        <property type="entry name" value="Decaprenyl diphosphate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00084036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020012.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="415" mass="46293" checksum="B11AA776C94461E5" modified="2018-02-28" version="2">MASRWWRWLRGCSWRPAARSPGPGCPGLAGPRGPQAAADAHAQVHRWKGLDLSQIPYINLVKHLTSACPNVYSISRFHHTTPDSKTHSGEKYTDPFKLGWRDLKGLYEDIRKELLISTSELKEMSEYYFDGKGKAFRPIIVALMARACNIHHNNSRHVQASQRTIALIAEMIHTASLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENENERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGLATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHEAIREISKLRPSPERDALIQLSEIVLTRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVY3</accession>
    <name>A0A0A0MVY3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YIF1B</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009192624.1">
        <property type="nucleotide sequence ID" value="XM_009194360.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVY3"/>
    <dbReference type="Ensembl" id="ENSPANT00000026022.3">
        <property type="protein sequence ID" value="ENSPANP00000008151.2"/>
        <property type="gene ID" value="ENSPANG00000005740.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101019275"/>
    <dbReference type="CTD" id="90522"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009423"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005740">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MVY3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF1">
        <property type="entry name" value="PROTEIN YIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008151.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="315" mass="34439" checksum="EDA31D5FD73829AF" modified="2018-02-28" version="2">MHPAGLAAAAAAGTPRLRKWPSKRRIPVSQPGMADPHQLFDDTSSTQSRGYGAQRAPGGLGYPAASATPQAAFLADPVSNMAMAYGSSLAAQGKELVDKNIDRFIPVTKLKYYFAVDTMYVGRKLGLLFFPYLHQDWEVQYQQDTPVAPRFDVNAPDLYIPAMAFITYVLVAGLALGTQDRFSPDLLGLQASSALAWLTLEVVAILLSLYLVTVNTDLTTIDLVAFLGYKYVGMIGGVLMGLLFGKIGYYLVLGWCCVAIFVFMIRTLRLKILAEAAAEGVPVRGARNQLRMYLTMAVAAAQPLLMYWLTFHLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWM2</accession>
    <name>A0A0A0MWM2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ral guanine nucleotide dissociation stimulator like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RGL3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWM2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009848"/>
    <dbReference type="Ensembl" id="ENSPANT00000013209.3">
        <property type="protein sequence ID" value="ENSPANP00000009848.3"/>
        <property type="gene ID" value="ENSPANG00000004121.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161935"/>
    <dbReference type="HOGENOM" id="CLU_010252_1_1_1"/>
    <dbReference type="OMA" id="YISCMIE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004121">
        <property type="expression patterns" value="Expressed in pancreas and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MWM2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17212">
        <property type="entry name" value="RA_RGL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030750">
        <property type="entry name" value="RGL3_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF220">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="247"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="609"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009848.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="706" mass="77874" checksum="42641178305A6275" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LE65</accession>
    <name>A0A2I3LE65_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-dependent metalloprotease SPRTN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein with SprT-like domain at the N terminus</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPRTN</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LE65"/>
    <dbReference type="STRING" id="9555.ENSPANP00000021727"/>
    <dbReference type="Ensembl" id="ENSPANT00000047042.2">
        <property type="protein sequence ID" value="ENSPANP00000021727.1"/>
        <property type="gene ID" value="ENSPANG00000017798.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003585"/>
    <dbReference type="OMA" id="VCQTEVL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017798">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LE65">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000331">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="18">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00023885"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021727.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="492" mass="55573" checksum="CF3A35D77538C338" modified="2018-02-28" version="1">MDDDLMLALRLQEEWNLQEAERDQAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCDGPCQYRPPYYGYVKRATNREPSAHDYWWAEHQKTCGGTYMKIKEPENYSKKGKGKTKLGKQPVSAAENKDKPNRGEAQLVIPFSGKGYVLGEASNLPSPGKLITSHAINKTQDLLNQNHSANAVRPNSKIKVKFEQNGSSKNSHLVSPAVNNSHQNVLSNYFPRVSVANQKAFRGVNGSPRKSETVGNIPKNSVSSSSQRRVSSSKISLRNSSKVMESTSVTPSRDVSGSEDTFPNKRPRLEDKTVFDNFFIKKEQIESSGNDPKYSSYPTTTTQNSSGSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDSIKVKSEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LFY8</accession>
    <name>A0A2I3LFY8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorting nexin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNX14</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_021937566.2"/>
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    <dbReference type="SMR" id="A0A2I3LFY8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000022361"/>
    <dbReference type="Ensembl" id="ENSPANT00000051826.2">
        <property type="protein sequence ID" value="ENSPANP00000022361.1"/>
        <property type="gene ID" value="ENSPANG00000009855.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017228"/>
    <dbReference type="CTD" id="57231"/>
    <dbReference type="GeneTree" id="ENSGT00950000182856"/>
    <dbReference type="OMA" id="MYVYVIS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009855">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LFY8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099170">
        <property type="term" value="P:postsynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RGS_SNX14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="sorting nexin-14 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="sorting nexin-14 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
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    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
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    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037436">
        <property type="entry name" value="SNX14_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037892">
        <property type="entry name" value="SNX14_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
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    <dbReference type="Pfam" id="PF02194">
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    </dbReference>
    <dbReference type="SMART" id="SM00312">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="11">
        <location>
            <begin position="130"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="9">
        <location>
            <begin position="336"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="570"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="946" mass="110243" checksum="CE2916458E2CC11A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LHP9</accession>
    <name>A0A2I3LHP9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corticotropin-releasing factor receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CRHR1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer; heterodimerizes with GPER1. Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003913274.1">
        <property type="nucleotide sequence ID" value="XM_003913225.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LHP9"/>
    <dbReference type="Ensembl" id="ENSPANT00000035237.2">
        <property type="protein sequence ID" value="ENSPANP00000022943.2"/>
        <property type="gene ID" value="ENSPANG00000021209.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003248"/>
    <dbReference type="KEGG" id="panu:101003248"/>
    <dbReference type="CTD" id="1394"/>
    <dbReference type="GeneTree" id="ENSGT00940000158410"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021209">
        <property type="expression patterns" value="Expressed in cerebellum and 34 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LHP9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015056">
        <property type="term" value="F:corticotrophin-releasing factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043404">
        <property type="term" value="F:corticotropin-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15445">
        <property type="entry name" value="7tmB1_CRF-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000021">
        <property type="entry name" value="Corticotropin releasing factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000007">
        <property type="entry name" value="Corticotropin-releasing factor receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003052">
        <property type="entry name" value="GPCR_2_CRF1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003051">
        <property type="entry name" value="GPCR_2_CRF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF2">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01279">
        <property type="entry name" value="CRFRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01280">
        <property type="entry name" value="CRFRECEPTOR1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035176172" description="Corticotropin-releasing factor receptor 1" evidence="17">
        <location>
            <begin position="24"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="119"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022943.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="415" mass="47770" checksum="B82382597EBF6BF2" modified="2022-05-25" version="2">MGRHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LKM8</accession>
    <name>A0A2I3LKM8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NALCN channel auxiliary factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NALF2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NALF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LKM8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000023985"/>
    <dbReference type="Ensembl" id="ENSPANT00000041213.2">
        <property type="protein sequence ID" value="ENSPANP00000023985.2"/>
        <property type="gene ID" value="ENSPANG00000032381.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161362"/>
    <dbReference type="OMA" id="QWVSCEA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032381">
        <property type="expression patterns" value="Expressed in thyroid gland and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055288">
        <property type="entry name" value="NALCN_aux_factor_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819:SF8">
        <property type="entry name" value="NALCN CHANNEL AUXILIARY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN FAM155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023985.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="474" mass="52833" checksum="BB2B1F9177FCC15A" modified="2022-05-25" version="2">MFRGAWMWPGKDAAALTICCCCCCWAPRPSDKPCADSERAQRWRLSLASLLFFTVLLADHLWLCAGARARPRARELSSAMRPPWGTGRERPPVPPRAVLPLPPPQPGEPSAPPGTCGPRYSNLTKAAPAAGSRPVCGGVPEPTGLDAACTKLQSLQRLFEPTTPAPPLRPPDSPSRGPAEFPSAKKNLLKGHFRNFTLSFCDTYTVWDLLLGMDRPDSLDCSLDTLLGDLLAVVASPGSGAWEACSNCIEAYQRLDRHAQEKYDEFDLVLHKYLQAEEYSIRSCTKGCKAVYKAWLCSEYFSVTQQECQRWVPCKQYCLEVQTRCPFILPDNEEMVYGGLPGFICTGLLDTSPKRPETKCCDVQWVSCEAKKKKFKESEAPKTHHQQFHHSYFHHYHQQYHHYHPRHEHPHRVSNKPALLPVSGGSRLSPSRIRLCVLVLMLLHTVVSFSSNQGGGGLGLETLPALEEGLTREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LPL6</accession>
    <name>A0A2I3LPL6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nephrocystin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NPHP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the nephrocystin-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LPL6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000025377"/>
    <dbReference type="Ensembl" id="ENSPANT00000040847.2">
        <property type="protein sequence ID" value="ENSPANP00000025377.2"/>
        <property type="gene ID" value="ENSPANG00000011993.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007701"/>
    <dbReference type="OMA" id="CYLIALM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011993">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LPL6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903348">
        <property type="term" value="P:positive regulation of bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090251">
        <property type="term" value="P:protein localization involved in establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11770">
        <property type="entry name" value="SH3_Nephrocystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000171">
        <property type="entry name" value="Nephrocystin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039687">
        <property type="entry name" value="NPHP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030642">
        <property type="entry name" value="NPHP1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15176">
        <property type="entry name" value="NEPHROCYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15176:SF1">
        <property type="entry name" value="NEPHROCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025377.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="735" mass="83613" checksum="8C2274D9F9C6A71E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LUX1</accession>
    <name>A0A2I3LUX1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Unconventional myosin-Va</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Dilute myosin heavy chain, non-muscle</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">May be a homodimer, which associates with multiple calmodulin or myosin light chains. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Interacts with MLPH. Interacts with SYTL4. Interacts with MYRIP. Interacts with RAB10; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles. Interacts with FMR1; this interaction occurs in association with polyribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031524533.1">
        <property type="nucleotide sequence ID" value="XM_031668673.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000050518.2">
        <property type="protein sequence ID" value="ENSPANP00000027237.2"/>
        <property type="gene ID" value="ENSPANG00000017406.3"/>
    </dbReference>
    <dbReference type="GeneID" id="116268656"/>
    <dbReference type="KEGG" id="panu:116268656"/>
    <dbReference type="GeneTree" id="ENSGT00940000155347"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017406">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LUX1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030050">
        <property type="term" value="P:vesicle transport along actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15478">
        <property type="entry name" value="Myo5a_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000002">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000006">
        <property type="entry name" value="Myosin VA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000089">
        <property type="entry name" value="Myosin VC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000003">
        <property type="entry name" value="Myosin-Va isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058662">
        <property type="entry name" value="Myo5a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037988">
        <property type="entry name" value="Myo5a_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF273">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
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    <dbReference type="Pfam" id="PF25966">
        <property type="entry name" value="Myo5a"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IQ"/>
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        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="21">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="69"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="19">
        <location>
            <begin position="1534"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1107"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="915"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1155"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1339"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1116"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027237.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1855" mass="215328" checksum="22D466DBEEBB497B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LVY5</accession>
    <name>A0A2I3LVY5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FIS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with DNM1L/DLP1 through the TPR region; may form part of a larger protein complex at the endoplasmic reticulum-mitochondrial interface during mitochondrial fission. Interacts with MARCHF5. Interacts with MIEF1. Interacts with PEX11A, PEX11B and PEX11G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895869.1">
        <property type="nucleotide sequence ID" value="XM_003895820.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I3LVY5"/>
    <dbReference type="SMR" id="A0A2I3LVY5"/>
    <dbReference type="Ensembl" id="ENSPANT00000058970.2">
        <property type="protein sequence ID" value="ENSPANP00000027620.2"/>
        <property type="gene ID" value="ENSPANG00000020761.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020996"/>
    <dbReference type="KEGG" id="panu:101020996"/>
    <dbReference type="CTD" id="51024"/>
    <dbReference type="GeneTree" id="ENSGT00390000000592"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020761">
        <property type="expression patterns" value="Expressed in lateral globus pallidus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LVY5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903579">
        <property type="term" value="P:negative regulation of ATP metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000192">
        <property type="term" value="P:negative regulation of fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
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    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
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    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
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    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027620.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="152" mass="16938" checksum="6E76EC02B3731A9B" modified="2022-05-25" version="2">MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LXB8</accession>
    <name>A0A2I3LXB8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP binding cassette subfamily G member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ABCG1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cholesterol(in) + ATP + H2O = cholesterol(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:39052"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LXB8"/>
    <dbReference type="Ensembl" id="ENSPANT00000059256.2">
        <property type="protein sequence ID" value="ENSPANP00000028098.2"/>
        <property type="gene ID" value="ENSPANG00000018700.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160131"/>
    <dbReference type="OMA" id="WWKQFWL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018700">
        <property type="expression patterns" value="Expressed in pericardial fat and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LXB8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034041">
        <property type="term" value="F:ABC-type sterol transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042987">
        <property type="term" value="P:amyloid precursor protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034436">
        <property type="term" value="P:glycoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000267">
        <property type="entry name" value="ATP-binding cassette, sub-family G (WHITE), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005284">
        <property type="entry name" value="Pigment_permease/Abcg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00955">
        <property type="entry name" value="3a01204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF90">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="94"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028098.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="703" mass="78095" checksum="98C0C80A06159F57" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LYQ2</accession>
    <name>A0A2I3LYQ2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LYQ2"/>
    <dbReference type="Ensembl" id="ENSPANT00000058538.2">
        <property type="protein sequence ID" value="ENSPANP00000028597.1"/>
        <property type="gene ID" value="ENSPANG00000032966.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282589"/>
    <dbReference type="OMA" id="YTWRWSE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032966">
        <property type="expression patterns" value="Expressed in amygdala and 64 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="154" mass="16922" checksum="112F941EB72C679D" modified="2018-02-28" version="1">MKKRHSEGYDMPGPWSALRSHRQHHCPHLHPVLRRPTLTDVEGCLQCLDVRGHSGHAVDAHLLHASALDLLHTLAHDVGDLGPLSPMEGGNVLSVLAALLGPQHRKPVPYLYTWRWSEDGDEDAQVWDCTQSLLHACPPSASPVLIACTFSGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M134</accession>
    <name>A0A2I3M134_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Omega-amidase NIT2</fullName>
            <ecNumber evidence="4">3.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nitrilase homolog 2</fullName>
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    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:32963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16769"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:32964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-oxosuccinamate + H2O = oxaloacetate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57735"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59413"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3M134"/>
    <dbReference type="Ensembl" id="ENSPANT00000057657.2">
        <property type="protein sequence ID" value="ENSPANP00000029425.2"/>
        <property type="gene ID" value="ENSPANG00000021638.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074838"/>
    <dbReference type="OMA" id="MQSKPYA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021638">
        <property type="expression patterns" value="Expressed in metanephros cortex and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M134">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029425.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="276" mass="30583" checksum="771E01A43F23B395" modified="2022-05-25" version="2">MATFRLALIQLQISSVKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGTKYFPEYAEKIPGGSTQKLSEVAKECNIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESETLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSRAVDNQVYVATASPARDDEASYVAWGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQMPVFRQKRSDLYAVEMKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M1N3</accession>
    <name>A0A2I3M1N3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ASXL transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ASXL1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904931.2">
        <property type="nucleotide sequence ID" value="XM_003904882.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000042242.2">
        <property type="protein sequence ID" value="ENSPANP00000029620.2"/>
        <property type="gene ID" value="ENSPANG00000025544.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013248"/>
    <dbReference type="KEGG" id="panu:101013248"/>
    <dbReference type="CTD" id="171023"/>
    <dbReference type="GeneTree" id="ENSGT00520000055578"/>
    <dbReference type="OMA" id="DGHFKRR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025544">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M1N3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042974">
        <property type="term" value="F:nuclear retinoic acid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042975">
        <property type="term" value="F:peroxisome proliferator activated receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048539">
        <property type="term" value="P:bone marrow development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060430">
        <property type="term" value="P:lung saccule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035359">
        <property type="term" value="P:negative regulation of peroxisome proliferator activated receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072015">
        <property type="term" value="P:podocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048386">
        <property type="term" value="P:positive regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035564">
        <property type="term" value="P:regulation of kidney size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF19">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN ASXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="12">
        <location>
            <begin position="255"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="212"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="546"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="718"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="748"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="897"/>
            <end position="974"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1042"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="107"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="159"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="212"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="513"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="536"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="641"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="660"/>
            <end position="671"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029620.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1541" mass="165546" checksum="D40C5F6404557EF8" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M3B3</accession>
    <name>A0A2I3M3B3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M3B3"/>
    <dbReference type="Ensembl" id="ENSPANT00000047408.2">
        <property type="protein sequence ID" value="ENSPANP00000030193.2"/>
        <property type="gene ID" value="ENSPANG00000035253.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153236"/>
    <dbReference type="OMA" id="CKECAFT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035253">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001737">
        <property type="entry name" value="Zinc finger protein 100"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000374">
        <property type="entry name" value="Zinc finger protein 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000034">
        <property type="entry name" value="zinc finger protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001868">
        <property type="entry name" value="Zinc finger protein 264"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000120">
        <property type="entry name" value="Zinc finger protein 430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002448">
        <property type="entry name" value="Zinc finger protein 430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000362">
        <property type="entry name" value="Zinc finger protein 606"/>
        <property type="match status" value="4"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF51">
        <property type="entry name" value="ZINC FINGER PROTEIN 833-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="209"/>
            <end position="236"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="460"/>
            <end position="487"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030193.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="538" mass="62729" checksum="CD428D13DCD9E0BE" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M690</accession>
    <name>A0A2I3M690_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Thrombospondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Glycoprotein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">THBS1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="19">Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Binds heparin. Interacts (via the C-terminal domain) with CD47. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36. Interacts with ATF6 (via lumenal domain). Interacts with FN1; this interaction is enhanced by TNFAIP6, which may act as a bridging molecule between FN1 and THBS1. Interacts with SIRPA; the interaction stimulates phosphorylation of SIRPA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Sarcoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900802.2">
        <property type="nucleotide sequence ID" value="XM_003900753.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M690"/>
    <dbReference type="SMR" id="A0A2I3M690"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031237"/>
    <dbReference type="Ensembl" id="ENSPANT00000040321.2">
        <property type="protein sequence ID" value="ENSPANP00000031237.2"/>
        <property type="gene ID" value="ENSPANG00000019502.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005612"/>
    <dbReference type="KEGG" id="panu:101005612"/>
    <dbReference type="CTD" id="7057"/>
    <dbReference type="GeneTree" id="ENSGT00940000155832"/>
    <dbReference type="OMA" id="ITQTYWD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019502">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M690">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:collagen V binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:fibrinogen binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030169">
        <property type="term" value="F:low-density lipoprotein particle binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protease binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072378">
        <property type="term" value="P:blood coagulation, fibrin clot formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002544">
        <property type="term" value="P:chronic inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002581">
        <property type="term" value="P:negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903588">
        <property type="term" value="P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090051">
        <property type="term" value="P:negative regulation of cell migration involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001953">
        <property type="term" value="P:negative regulation of cell-matrix adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010754">
        <property type="term" value="P:negative regulation of cGMP-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002605">
        <property type="term" value="P:negative regulation of dendritic cell antigen processing and presentation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001027">
        <property type="term" value="P:negative regulation of endothelial cell chemotaxis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051918">
        <property type="term" value="P:negative regulation of fibrinolysis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032693">
        <property type="term" value="P:negative regulation of interleukin-10 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032695">
        <property type="term" value="P:negative regulation of interleukin-12 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010748">
        <property type="term" value="P:negative regulation of long-chain fatty acid import across plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010751">
        <property type="term" value="P:negative regulation of nitric oxide mediated signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010757">
        <property type="term" value="P:negative regulation of plasminogen activation"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038060">
        <property type="term" value="P:nitric oxide-cGMP-mediated signaling"/>
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    </dbReference>
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        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050921">
        <property type="term" value="P:positive regulation of chemotaxis"/>
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    </dbReference>
    <dbReference type="GO" id="GO:2000353">
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    </dbReference>
    <dbReference type="GO" id="GO:1902043">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010763">
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        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="term" value="P:positive regulation of reactive oxygen species metabolic process"/>
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        <property type="term" value="P:positive regulation of smooth muscle cell proliferation"/>
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        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to calcium ion"/>
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        <property type="term" value="P:response to glucose"/>
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        <property type="term" value="P:response to magnesium ion"/>
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    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:response to xenobiotic stimulus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:sprouting angiogenesis"/>
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        <property type="entry name" value="Laminin"/>
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    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
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    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF78">
        <property type="entry name" value="THROMBOSPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 22" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 25" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035321135" description="Thrombospondin-1" evidence="25">
        <location>
            <begin position="19"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="27">
        <location>
            <begin position="316"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="547"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="646"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="23">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="23">
        <location>
            <begin position="786"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="23">
        <location>
            <begin position="883"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="23">
        <location>
            <begin position="919"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="28">
        <location>
            <begin position="958"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="839"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031237.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129452" checksum="50D47E06C754EAAB" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MBG0</accession>
    <name>A0A2I3MBG0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOX high mobility group box family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TOX2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MBG0"/>
    <dbReference type="Ensembl" id="ENSPANT00000041067.2">
        <property type="protein sequence ID" value="ENSPANP00000032975.1"/>
        <property type="gene ID" value="ENSPANG00000023990.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158764"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023990">
        <property type="expression patterns" value="Expressed in aorta and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MBG0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21995">
        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000005">
        <property type="entry name" value="TOX high mobility group box family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051365">
        <property type="entry name" value="TOX_HMG-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781">
        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF5">
        <property type="entry name" value="TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="254"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="254"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="487" mass="51402" checksum="CB1D62C3A9AA85F4" modified="2018-02-28" version="1">MQQTRTEAVAGAFSRCLGFCGMRLGLLLLARRWCIAGVPQKFDGDSAYVGMSDGNPELLSTSQTFNSQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRSAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEAHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPASQPPVLPAPMALQVQLAMSPSPPGPQDFSHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLLPRDKSLYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MPE2</accession>
    <name>A0A2I3MPE2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein PAT1 homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PAT1-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein PAT1 homolog b</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PATL1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003919726.2">
        <property type="nucleotide sequence ID" value="XM_003919677.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MPE2"/>
    <dbReference type="SMR" id="A0A2I3MPE2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037525"/>
    <dbReference type="Ensembl" id="ENSPANT00000048577.2">
        <property type="protein sequence ID" value="ENSPANP00000037525.1"/>
        <property type="gene ID" value="ENSPANG00000035620.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101018860"/>
    <dbReference type="KEGG" id="panu:101018860"/>
    <dbReference type="CTD" id="219988"/>
    <dbReference type="GeneTree" id="ENSGT00520000055649"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035620">
        <property type="expression patterns" value="Expressed in gastrocnemius and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF2">
        <property type="entry name" value="PROTEIN PAT1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="13">
        <location>
            <begin position="474"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="770" mass="86843" checksum="BA5256B335CB5B91" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MPV2</accession>
    <name>A0A2I3MPV2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARK2C</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Arkadia family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MPV2"/>
    <dbReference type="SMR" id="A0A2I3MPV2"/>
    <dbReference type="Ensembl" id="ENSPANT00000055889.2">
        <property type="protein sequence ID" value="ENSPANP00000037769.2"/>
        <property type="gene ID" value="ENSPANG00000025287.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999191"/>
    <dbReference type="KEGG" id="panu:100999191"/>
    <dbReference type="CTD" id="494470"/>
    <dbReference type="GeneTree" id="ENSGT00940000156997"/>
    <dbReference type="OMA" id="HFTRHHN"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025287">
        <property type="expression patterns" value="Expressed in subcutaneous adipose tissue and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MPV2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035136">
        <property type="term" value="P:forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16682">
        <property type="entry name" value="RING-H2_RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000058">
        <property type="entry name" value="E3 ubiquitin-protein ligase Arkadia isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037769.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="346" mass="39526" checksum="93A5B777988C339C" modified="2022-05-25" version="2">MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQLAPDFPLAHPVQSQPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRRLVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGTDWDLSVDAGLSPAQFQVRPIPQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLALQGLNPSRHTSAVRESYEELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MSB4</accession>
    <name>A0A2I3MSB4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">IDH3G</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918518.1">
        <property type="nucleotide sequence ID" value="XM_003918469.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MSB4"/>
    <dbReference type="SMR" id="A0A2I3MSB4"/>
    <dbReference type="Ensembl" id="ENSPANT00000048893.2">
        <property type="protein sequence ID" value="ENSPANP00000038516.1"/>
        <property type="gene ID" value="ENSPANG00000023323.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017621"/>
    <dbReference type="KEGG" id="panu:101017621"/>
    <dbReference type="CTD" id="3421"/>
    <dbReference type="GeneTree" id="ENSGT00950000182989"/>
    <dbReference type="OMA" id="PWSCDYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023323">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MSB4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000011">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF78">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 15" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="56"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="393" mass="42789" checksum="CD46E5DEE83D64BA" modified="2018-02-28" version="1">MALKVATVAGGAAKAVLRPALLCRPWEVLGAHEVPSRSISSQQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIRVINGRAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MWT2</accession>
    <name>A0A2I3MWT2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MWT2"/>
    <dbReference type="Ensembl" id="ENSPANT00000037208.2">
        <property type="protein sequence ID" value="ENSPANP00000040239.1"/>
        <property type="gene ID" value="ENSPANG00000031341.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153130"/>
    <dbReference type="OMA" id="WVSSQKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031341">
        <property type="expression patterns" value="Expressed in thymus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04983">
        <property type="entry name" value="IgV_TCR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051006">
        <property type="entry name" value="TCR_variable_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343:SF13">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="127" mass="14507" checksum="A36494FA48CEFDC4" modified="2018-02-28" version="1">SQKIEQNSEALNIQEGKTATLTCNYTNYSPSYLQWYRQDPGRGPVFLLLIRENEKEKWKERLKVTFDTTLKQSLFHITASQPADSATYLCALDTQWCPGSCFLHPNSAHSYNQSSWLCCLLKADHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MX66</accession>
    <name>A0A2I3MX66_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Equatorin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EQTN</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MX66"/>
    <dbReference type="Ensembl" id="ENSPANT00000031221.2">
        <property type="protein sequence ID" value="ENSPANP00000040206.2"/>
        <property type="gene ID" value="ENSPANG00000025274.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010786"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025274">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MX66">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002079">
        <property type="term" value="C:inner acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002081">
        <property type="term" value="C:outer acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060478">
        <property type="term" value="P:acrosomal vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029282">
        <property type="entry name" value="Eqtn/Afaf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36874">
        <property type="entry name" value="EQUATORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36874:SF1">
        <property type="entry name" value="EQUATORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15339">
        <property type="entry name" value="Afaf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035224299" evidence="3">
        <location>
            <begin position="17"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040206.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="339" mass="38091" checksum="70079FCC65031FEC" modified="2022-05-25" version="2">MVSFFLLFFFSRCSLPKELPSDLQEDPVPPFPGLCPRLHPPLRPGHCDGCRGPCQHLLQTFLLLCHRDEPHRPQGARAFALPNVMPLNEDVNKQEEKHEDHPHNYAPANEKNGNYYKDIKQYVLTTQNPNGTESEITVRATTDLNFSLKNYKIVNATTYEKSASEEETTTNEPSHKNIPRSTPNLPAFWTMLAKAINGTTVVMDDKDQLFHPIPESDVNATQGENQPDLEDLKIKLMLGISLMTLLLFVVLLAFCSATLYKLRHLTYKNCESQYSVNPELATMSYFHPSEGVSDTSFSKSGESSTLLGTTSSDMRRSGTRTSESKMMTDISTGSDDEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N3B5</accession>
    <name>A0A2I3N3B5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box/WD repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FBXW7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003899315.1">
        <property type="nucleotide sequence ID" value="XM_003899266.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N3B5"/>
    <dbReference type="SMR" id="A0A2I3N3B5"/>
    <dbReference type="Ensembl" id="ENSPANT00000043573.2">
        <property type="protein sequence ID" value="ENSPANP00000042503.1"/>
        <property type="gene ID" value="ENSPANG00000025492.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006527"/>
    <dbReference type="KEGG" id="panu:101006527"/>
    <dbReference type="CTD" id="55294"/>
    <dbReference type="GeneTree" id="ENSGT00940000154986"/>
    <dbReference type="OMA" id="AMVPWED"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025492">
        <property type="expression patterns" value="Expressed in olfactory bulb and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N3B5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001205">
        <property type="term" value="P:negative regulation of osteoclast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903378">
        <property type="term" value="P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901800">
        <property type="term" value="P:positive regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22133">
        <property type="entry name" value="F-box_FBXW7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000032">
        <property type="entry name" value="F-box/WD repeat-containing protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="497"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="627" mass="70324" checksum="3D4107C053381BED" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N3D5</accession>
    <name>A0A2I3N3D5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Elongation factor sec</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Eukaryotic elongation factor, selenocysteine-tRNA-specific</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">EEFSEC</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003906958.1">
        <property type="nucleotide sequence ID" value="XM_003906909.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N3D5"/>
    <dbReference type="Ensembl" id="ENSPANT00000038901.2">
        <property type="protein sequence ID" value="ENSPANP00000042522.2"/>
        <property type="gene ID" value="ENSPANG00000017041.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999860"/>
    <dbReference type="KEGG" id="panu:100999860"/>
    <dbReference type="CTD" id="60678"/>
    <dbReference type="GeneTree" id="ENSGT00940000158170"/>
    <dbReference type="OMA" id="CFAIKGQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017041">
        <property type="expression patterns" value="Expressed in metanephros cortex and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N3D5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01889">
        <property type="entry name" value="SelB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000900">
        <property type="entry name" value="Eukaryotic elongation factor, selenocysteine-tRNA-specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="19">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042522.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="596" mass="65151" checksum="7738839BA6D19F75" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NCI7</accession>
    <name>A0A2I3NCI7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 783</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF783</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3NCI7"/>
    <dbReference type="Ensembl" id="ENSPANT00000032235.2">
        <property type="protein sequence ID" value="ENSPANP00000045774.2"/>
        <property type="gene ID" value="ENSPANG00000008719.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162942"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008719">
        <property type="expression patterns" value="Expressed in cornea and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NCI7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001386">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000496">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF120">
        <property type="entry name" value="ZINC FINGER PROTEIN 783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="198"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB-related" evidence="15">
        <location>
            <begin position="570"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="573"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="728"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="939"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045774.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="969" mass="108436" checksum="6F9CB2F0D6237289" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NGG8</accession>
    <name>A0A2I3NGG8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Astrotactin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ASTN2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="23">Interacts with ASTN1; the interaction is not calcium-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the astrotactin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017804823.2">
        <property type="nucleotide sequence ID" value="XM_017949334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NGG8"/>
    <dbReference type="Ensembl" id="ENSPANT00000041607.2">
        <property type="protein sequence ID" value="ENSPANP00000046936.2"/>
        <property type="gene ID" value="ENSPANG00000025801.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011854"/>
    <dbReference type="CTD" id="23245"/>
    <dbReference type="GeneTree" id="ENSGT00390000003140"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025801">
        <property type="expression patterns" value="Expressed in pineal body and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NGG8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043533">
        <property type="term" value="F:inositol 1,3,4,5 tetrakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000288">
        <property type="entry name" value="Astrotactin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040685">
        <property type="entry name" value="Annexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045574">
        <property type="entry name" value="ASTN1_2_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045575">
        <property type="entry name" value="ASTN_1_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040510">
        <property type="entry name" value="ASTN_2_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026995">
        <property type="entry name" value="Astrotactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592">
        <property type="entry name" value="ASTROTACTIN-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592:SF2">
        <property type="entry name" value="ASTROTACTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18411">
        <property type="entry name" value="Annexin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19743">
        <property type="entry name" value="ASTN1_2_fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19441">
        <property type="entry name" value="ASTN_1_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18577">
        <property type="entry name" value="ASTN_2_hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 27" id="KW-0732">Signal</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266113" description="Astrotactin-2" evidence="27">
        <location>
            <begin position="50"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="28">
        <location>
            <begin position="799"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00071694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046936.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1287" mass="142671" checksum="F3368B427447606D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NHC2</accession>
    <name>A0A2I3NHC2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARPC5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009190100.1">
        <property type="nucleotide sequence ID" value="XM_009191836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NHC2"/>
    <dbReference type="SMR" id="A0A2I3NHC2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000047383"/>
    <dbReference type="Ensembl" id="ENSPANT00000056673.2">
        <property type="protein sequence ID" value="ENSPANP00000047383.2"/>
        <property type="gene ID" value="ENSPANG00000005961.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005664"/>
    <dbReference type="KEGG" id="panu:101005664"/>
    <dbReference type="CTD" id="10092"/>
    <dbReference type="GeneTree" id="ENSGT00940000154654"/>
    <dbReference type="OMA" id="GMGCIMR"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005961">
        <property type="expression patterns" value="Expressed in spleen and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NHC2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047383.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="151" mass="16288" checksum="F050B10DC5416E66" modified="2022-05-25" version="2">MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAVLLQWHEKALAAGGVGSIVRVLTARKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NHD9</accession>
    <name>A0A2I3NHD9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">THOC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000047325"/>
    <dbReference type="Ensembl" id="ENSPANT00000057939.2">
        <property type="protein sequence ID" value="ENSPANP00000047325.2"/>
        <property type="gene ID" value="ENSPANG00000004038.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00710000106792"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Onwere C.O."/>
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                <person name="Pham C.P."/>
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    <accession>A0A8I5N2K0</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
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                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
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                <person name="Nguyen N.N."/>
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                <person name="Okwuonu G.O."/>
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                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N2K0"/>
    <dbReference type="Ensembl" id="ENSPANT00000080849.1">
        <property type="protein sequence ID" value="ENSPANP00000050072.1"/>
        <property type="gene ID" value="ENSPANG00000050207.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF12">
        <property type="entry name" value="RNA BINDING MOTIF SINGLE STRANDED INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="141" mass="15985" checksum="3E88E338B8B10269" modified="2022-05-25" version="1">MSSDGNIPIFLLNTYRMESCSVTRLEYSSMISLQPLPPRFKRYPCLNLPSSWEYRHVSRRPANFLYFSRDEVLPCWPGWSRSPDLVIPPASASQSAGITGVSHCAWPVFYDSNQKAHFEARGRAHCYTNLLLGDAGIGVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N2R7</accession>
    <name>A0A8I5N2R7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyroglutamylated RF-amide peptide receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">AQ27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">G-protein coupled receptor 103</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Orexigenic neuropeptide QRFP receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">SP9155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">QRFPR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899189.2">
        <property type="nucleotide sequence ID" value="XM_003899140.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N2R7"/>
    <dbReference type="Ensembl" id="ENSPANT00000064790.1">
        <property type="protein sequence ID" value="ENSPANP00000053995.1"/>
        <property type="gene ID" value="ENSPANG00000039070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025843"/>
    <dbReference type="KEGG" id="panu:101025843"/>
    <dbReference type="CTD" id="84109"/>
    <dbReference type="GeneTree" id="ENSGT01150000286926"/>
    <dbReference type="OMA" id="IHMMIEY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15205">
        <property type="entry name" value="7tmA_QRFPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000227">
        <property type="entry name" value="Pyroglutamylated RFamide peptide receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF20">
        <property type="entry name" value="PYROGLUTAMYLATED RFAMIDE PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="62"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082019"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="431" mass="49422" checksum="14731D8D844C17BB" modified="2022-05-25" version="1">MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLQTIHGKEMSKIARKKKRAVIMMATVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMQKKAKFSLRENPVEETKGETFSDGNIEVKLCEQTKEIKKLKRHLALFRSELAENSTLDSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N432</accession>
    <name>A0A8I5N432_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 112</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021786858.1">
        <property type="nucleotide sequence ID" value="XM_021931166.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031515234.1">
        <property type="nucleotide sequence ID" value="XM_031659374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031518327.1">
        <property type="nucleotide sequence ID" value="XM_031662467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N432"/>
    <dbReference type="Ensembl" id="ENSPANT00000071053.1">
        <property type="protein sequence ID" value="ENSPANP00000050420.1"/>
        <property type="gene ID" value="ENSPANG00000043951.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000080307.1">
        <property type="protein sequence ID" value="ENSPANP00000049847.1"/>
        <property type="gene ID" value="ENSPANG00000039667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101010104"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Papio anubis</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
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                <person name="Rogers J.R."/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1200" mass="140087" checksum="FE2AF10910254EF3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC17</accession>
    <name>A0A8I5NC17_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC17"/>
    <dbReference type="Ensembl" id="ENSPANT00000079114.1">
        <property type="protein sequence ID" value="ENSPANP00000059041.1"/>
        <property type="gene ID" value="ENSPANG00000050646.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="94" mass="11058" checksum="96D15E6900597C45" modified="2022-05-25" version="1">FQEECHQVLFVPLVKFDCESLWSWAFFLVCRLLITAITSELVIGLFKDLTSSWFSLGRVYVSRNYPFLLDFLVYLHRIFFCIFCRDGISPCCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCB9</accession>
    <name>A0A8I5NCB9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031522966.1">
        <property type="nucleotide sequence ID" value="XM_031667106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522967.1">
        <property type="nucleotide sequence ID" value="XM_031667107.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522968.1">
        <property type="nucleotide sequence ID" value="XM_031667108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCB9"/>
    <dbReference type="SMR" id="A0A8I5NCB9"/>
    <dbReference type="Ensembl" id="ENSPANT00000076945.1">
        <property type="protein sequence ID" value="ENSPANP00000054551.1"/>
        <property type="gene ID" value="ENSPANG00000046969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100997320"/>
    <dbReference type="KEGG" id="panu:100997320"/>
    <dbReference type="CTD" id="64928"/>
    <dbReference type="GeneTree" id="ENSGT00390000001121"/>
    <dbReference type="OMA" id="RCIHVYT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000004">
        <property type="entry name" value="39S ribosomal protein L14, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="145" mass="15954" checksum="8C337060F8172214" modified="2022-05-25" version="1">MAFFTGLWGPFTCVRRALSHRCFSTTGSLSAIQKMTRVRVVDNSALGNSAYHRAPRCIHVYNKNGVGKVGDQILLAIKGQKKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIKTPIPSSLRKREGEYSKVLAIAQNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NER6</accession>
    <name>A0A8I5NER6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NER6"/>
    <dbReference type="Ensembl" id="ENSPANT00000075363.1">
        <property type="protein sequence ID" value="ENSPANP00000052581.1"/>
        <property type="gene ID" value="ENSPANG00000044422.1"/>
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    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="IILEWYT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
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    <dbReference type="GO" id="GO:0003964">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
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    </dbReference>
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        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR005135">
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    <dbReference type="InterPro" id="IPR000477">
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
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    <dbReference type="Pfam" id="PF00078">
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        <property type="entry name" value="DNA/RNA polymerases"/>
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        <property type="entry name" value="RT_POL"/>
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        <location>
            <begin position="498"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Ensembl" id="ENSPANP00000052581.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1275" mass="149187" checksum="02B7D359933AD4C6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFB7</accession>
    <name>A0A8I5NFB7_PAPAN</name>
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        <submittedName>
            <fullName evidence="10">Forkhead box J2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FOXJ2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001228">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="FORKHEAD BOX PROTEIN J2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
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    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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            <end position="182"/>
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            <end position="100"/>
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            <begin position="164"/>
            <end position="272"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="306"/>
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            <begin position="603"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="7" type="primary">TEX13D</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the TEX13 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="TEX13A/C/D_Znf"/>
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        <property type="entry name" value="TX13C/D_rpt"/>
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    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
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        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 13D"/>
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    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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        <property type="entry name" value="Zn_ribbon_TEX13"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NG35"/>
    <dbReference type="Ensembl" id="ENSPANT00000060804.1">
        <property type="protein sequence ID" value="ENSPANP00000048033.1"/>
        <property type="gene ID" value="ENSPANG00000041592.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286912"/>
    <dbReference type="OMA" id="HQIPGYI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:olfactory receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd15952">
        <property type="entry name" value="7tmA_OR52E-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF355">
        <property type="entry name" value="OLFACTORY RECEPTOR 52J3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="312" mass="35271" checksum="FC14ED8BD81384C0" modified="2022-05-25" version="1">MVYHGNRSTFHPATFFLVGIPGLEDVHMWISLPFCSVYLVALLGNATILLVIKAEQTLQEPMLYFLAILSTTDLALSTTCVPRMLGIFWFDAHEINFGACVAQMFLIHAFTGMEAEVLVAMAFDRYMAICNPLHYTNILTSRVLVGITMCIVIRPVLFTLPIIYLVYRLPFCQAHIIAHSYCEHMGIAKLSCGNIRVNAIYGLFVVSLFLLNLVLIVISYVYVLRAVFRLPSHDARLKALSTCGSHVGVICVFYIPSVFSFLTHRFGHSIPHYIHILVANLYLVVPPSLNPIIYGVRTKWIRERVIYVLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHL1</accession>
    <name>A0A8I5NHL1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Murine leukemia virus integrase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A8I5NHL1"/>
    <dbReference type="Ensembl" id="ENSPANT00000062673.1">
        <property type="protein sequence ID" value="ENSPANP00000051644.1"/>
        <property type="gene ID" value="ENSPANG00000051355.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164768"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Core shell protein Gag P30" evidence="8">
        <location>
            <begin position="71"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Murine leukemia virus integrase C-terminal" evidence="9">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="374" mass="41401" checksum="AF1BBACE78138DDB" modified="2022-05-25" version="1">MEQADGRRPAHTGPLKRKVTLKGQRGRREGALCGLAPPQSPDSTVALPLREIGPPDNTGILRLQYWPFSTSDLYNWKTQSTRCSDNPKDLLALLDSVMFTHQPTWDDYQQLLRILFTMEERERIQIEARKLVPGDDGQPTTNPDLINATFPLTRPAWDYNTAEALQKIHQEIWPKLKELYETSPPPTPHPYQPGDWVLVKRHRQETLEPRWKGPLQVLLTTPTALKVKGIASWIHYTHVKPVDPTSDLLGPITAAAEAPATWTVDRAKNLSSPSVTNLLCLPVTLVPRLTLLTAGEFLGYTGNWTSAAIHPVPRPRPAQAIFLPLIAGISLTASLIAVGLAGGALGHTLIESNKLYQQFAIAMEESAESLASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKP0</accession>
    <name>A0A8I5NKP0_PAPAN</name>
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        <submittedName>
            <fullName evidence="15">Protein phosphatase 1 regulatory subunit 9B</fullName>
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    </protein>
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        <name evidence="15" type="primary">PPP1R9B</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <sequence length="817" mass="89279" checksum="348DBA28DEBA096D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NL28</accession>
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        <recommendedName>
            <fullName evidence="12">Sidoreflexin</fullName>
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    <gene>
        <name evidence="14" type="primary">SFXN3</name>
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        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine(in) = L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:35031"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NL28"/>
    <dbReference type="Ensembl" id="ENSPANT00000082931.1">
        <property type="protein sequence ID" value="ENSPANP00000060751.1"/>
        <property type="gene ID" value="ENSPANG00000021121.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234641"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF20">
        <property type="entry name" value="SIDEROFLEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="349" mass="38314" checksum="00775913E9E8AD79" modified="2022-05-25" version="1">MGELPLDINIQEPRWDQSTFLGRARHFFTVTDPRNLLLSAAQLETSRNIVQNYRAGVVTPGITEDQLWRAKYVYDSAFHPDTGEKVVLIGRMSAQVPMNMTITGCMLTFYRKTPTVVFWQWVNQSFNAIVNYSNRSGDTPITVRQLGTAYVSATTGAVATALGLKSLTKHLPPLVGRFVPFAAVAAANCINIPLMRQRELQVGIPVADEAGQRLGYSVTAAKQGIFQVVISRICMAIPAMAIPPLIMDTLEKKDFLKVGNSTSPVLEWGMAGRRSDQAPTLSPAWSESLRLASRSPDPCTTSSTFIHSARMNWAGVKEHCGGRRRGRGKETNFISVTPGASDTQRRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMI4</accession>
    <name>A0A8I5NMI4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Desumoylating isopeptidase 1</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PPPDE peptidase domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Palmitoyl protein thioesterase DESI1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">S-depalmitoylase DESI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DESI1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with UBQLN4; leading to the export of UBQLN4 from the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031512116.1">
        <property type="nucleotide sequence ID" value="XM_031656256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NMI4"/>
    <dbReference type="SMR" id="A0A8I5NMI4"/>
    <dbReference type="Ensembl" id="ENSPANT00000064442.1">
        <property type="protein sequence ID" value="ENSPANP00000051360.1"/>
        <property type="gene ID" value="ENSPANG00000045717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101007703"/>
    <dbReference type="KEGG" id="panu:101007703"/>
    <dbReference type="CTD" id="27351"/>
    <dbReference type="GeneTree" id="ENSGT00730000111100"/>
    <dbReference type="OMA" id="HLMLGKQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1720.30:FF:000002">
        <property type="entry name" value="Desumoylating isopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="16">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="168" mass="18263" checksum="D902AF6FE5DDA31A" modified="2022-05-25" version="1">MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMX7</accession>
    <name>A0A8I5NMX7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPX3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NMX7"/>
    <dbReference type="Ensembl" id="ENSPANT00000068060.1">
        <property type="protein sequence ID" value="ENSPANP00000054879.1"/>
        <property type="gene ID" value="ENSPANG00000034534.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161754"/>
    <dbReference type="OMA" id="GRPIMRW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000112">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF32">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035187916" description="Glutathione peroxidase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="225" mass="25414" checksum="D064576C1F77A4D4" modified="2022-05-25" version="1">MARLLQASCLLSLLLAGFLPQSRGQDKSKMDCHGGVSGTIYEYGALTIDGEEYIPFKQYTGKYVLFVNVASYGLTGQYIELNALQEELAPFGLVLLGFPCNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPVMRWHHRTTISNVKMDILSYMRRQAALGVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NRH3</accession>
    <name>A0A8I5NRH3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NRH3"/>
    <dbReference type="Ensembl" id="ENSPANT00000073793.1">
        <property type="protein sequence ID" value="ENSPANP00000059579.1"/>
        <property type="gene ID" value="ENSPANG00000037928.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004856"/>
    <dbReference type="OMA" id="RPSEQIW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="82" mass="9064" checksum="C0690390C883C56F" modified="2022-05-25" version="1">QEEEGRRKVGQERQRPSEQIWGQGQKEAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NSH3</accession>
    <name>A0A8I5NSH3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-crystallin B2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Beta-B2 crystallin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-crystallin Bp</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905385.1">
        <property type="nucleotide sequence ID" value="XM_003905336.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSH3"/>
    <dbReference type="SMR" id="A0A8I5NSH3"/>
    <dbReference type="Ensembl" id="ENSPANT00000071074.1">
        <property type="protein sequence ID" value="ENSPANP00000060191.1"/>
        <property type="gene ID" value="ENSPANG00000025051.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999123"/>
    <dbReference type="KEGG" id="panu:100999123"/>
    <dbReference type="GeneTree" id="ENSGT00940000160048"/>
    <dbReference type="OMA" id="FRPIKQD"/>
    <dbReference type="OrthoDB" id="8525367at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000005">
        <property type="entry name" value="Crystallin, beta B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000002">
        <property type="entry name" value="Crystallin, beta B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF11">
        <property type="entry name" value="BETA-CRYSTALLIN B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="205" mass="23380" checksum="FD95C354724A67D0" modified="2022-05-25" version="1">MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NTP5</accession>
    <name>A0A8I5NTP5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NTP5"/>
    <dbReference type="Ensembl" id="ENSPANT00000075407.1">
        <property type="protein sequence ID" value="ENSPANP00000061011.1"/>
        <property type="gene ID" value="ENSPANG00000040456.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166898"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="132" mass="15009" checksum="3E67F9151A50081F" modified="2022-05-25" version="1">MANKKCERACERQKELDRFLIGFCCCHCLRQGLTLSPRLECSNASSAHCNLHLLGSSDFPASASRVSGSTGTHHHALLIFVYFGRHRVENDEDALIEAEAGGHDFPDRKKQKERERGFLIPRETNYFSSWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P035</accession>
    <name>A0A8I5P035_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box/LRR-repeat protein 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">F-box and leucine-rich repeat protein 17</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-box only protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FBXL17</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL17) composed of CUL1, SKP1, RBX1 and FBXL17. Interacts with BTB domain-containing proteins such as KLHL12, BCL6 and BACH1; specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition. Interacts with SUFU. Interacts with PRMT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FBXL17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900021.1">
        <property type="nucleotide sequence ID" value="XM_003899972.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P035"/>
    <dbReference type="Ensembl" id="ENSPANT00000064715.1">
        <property type="protein sequence ID" value="ENSPANP00000057174.1"/>
        <property type="gene ID" value="ENSPANG00000011933.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000378"/>
    <dbReference type="KEGG" id="panu:101000378"/>
    <dbReference type="CTD" id="64839"/>
    <dbReference type="GeneTree" id="ENSGT00940000156973"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22092">
        <property type="entry name" value="F-box_FBXO13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000161">
        <property type="entry name" value="F-box/LRR-repeat protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000358">
        <property type="entry name" value="F-box/LRR-repeat protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000038">
        <property type="entry name" value="F-box/LRR-repeat protein 17 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF72">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="96"/>
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    </feature>
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            <begin position="229"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="703" mass="75917" checksum="0A86EF0D94C9A2A4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P0K8</accession>
    <name>A0A8I5P0K8_PAPAN</name>
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        <submittedName>
            <fullName evidence="8">Elongin A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ELOA2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003914351.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A8I5P0K8"/>
    <dbReference type="Ensembl" id="ENSPANT00000060996.1">
        <property type="protein sequence ID" value="ENSPANP00000057570.1"/>
        <property type="gene ID" value="ENSPANG00000049945.1"/>
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    <dbReference type="GeneID" id="101001863"/>
    <dbReference type="KEGG" id="panu:101001863"/>
    <dbReference type="CTD" id="51224"/>
    <dbReference type="GeneTree" id="ENSGT00390000002428"/>
    <dbReference type="OMA" id="KMIYFNS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000010">
        <property type="entry name" value="elongin-A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
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    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
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    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
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    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF74">
        <property type="entry name" value="TFIIS N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="140"/>
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            <begin position="178"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="687"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P0Y1</accession>
    <name>A0A8I5P0Y1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P0Y1"/>
    <dbReference type="Ensembl" id="ENSPANT00000078659.1">
        <property type="protein sequence ID" value="ENSPANP00000057858.1"/>
        <property type="gene ID" value="ENSPANG00000040788.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="ANFCIFW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="107" mass="12110" checksum="8FF0C137F7705F40" modified="2022-05-25" version="1">MMPSEALSCLNSLPIFPFLLSLLCSILFFYSLLFFFSQMESCSVAQAGVQWRNLGLLQPLPPRFKQFSCLSLPNSWGYRCAPSHPANFYISSRDRGFTMLARLVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P427</accession>
    <name>A0A8I5P427_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5P427"/>
    <dbReference type="Ensembl" id="ENSPANT00000069244.1">
        <property type="protein sequence ID" value="ENSPANP00000060801.1"/>
        <property type="gene ID" value="ENSPANG00000039817.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163390"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="382" mass="41989" checksum="11FBDA2EFD9FBF43" modified="2022-05-25" version="1">MPAYWRPSNRVANHRLSRLSGYPGSSSATSWLRLFPVRGSCNFRLFPPRVPISCVCPRVPKPAPEMSTRGFRVGTNLERQWPSLYGLRWLLGLGLLLRLQGRPLHGFLPPQANRGQSARRSKKSHFVSFLLTKQKCVKVCVKSYDQDQMDKLAFLKKGIRLNYQHHCYKHSDENPATCNGPPVEIPGEYTDKLNVTYTYSVRLKKTKLSSGLLGGIRFWSLCLILIFSGFGLSCLGFPSPANGGALMTCATVLWVLLGTPARYVSAIMYKTFRGVKWKTNALLTALLCPGVSLSPRLKGSGPTMAHCSLDLLGSSDPSISTFQVAETTETGSHYVAQADLELLASSDLPTSASQSAGITGMSHCAWPCFLNVPLKKHLVSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZN4</accession>
    <name>A0A8I5QZN4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">H/ACA ribonucleoprotein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZN4"/>
    <dbReference type="Ensembl" id="ENSPANT00000074393.1">
        <property type="protein sequence ID" value="ENSPANP00000049702.1"/>
        <property type="gene ID" value="ENSPANG00000048738.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012563"/>
    <dbReference type="OMA" id="AEYYINE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="64" mass="7556" checksum="A028B09B4296E417" modified="2022-05-25" version="1">MFLQYYLSEQGDWVYTLEKFDPMGQQTCSALPAQFSPDDKYSRHRITIKKGFKVLMTQQLHPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R1Q9</accession>
    <name>A0A8I5R1Q9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R1Q9"/>
    <dbReference type="Ensembl" id="ENSPANT00000067346.1">
        <property type="protein sequence ID" value="ENSPANP00000056821.1"/>
        <property type="gene ID" value="ENSPANG00000022676.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162863"/>
    <dbReference type="OMA" id="TEMHRRE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF13">
        <property type="entry name" value="NUCLEOPORIN 62 C-TERMINAL LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="4">
        <location>
            <begin position="179"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="383" mass="43416" checksum="AE6F2832B61E3B8A" modified="2022-05-25" version="1">MPSLYNWLFLSSFFFFFFFLDGVLLCRQAGVQWRNLGSVQPLPPGFKRFSCLGLLSSWDYRRAPLHPANLFFIFSRDGVSPCWPGSSLSLDLYPPDLASQSLAPAAAVATTTSSSTMQFTSISNALTSTAAIGLSFTTSTTTTTTFTTNTTTTITSGFTVNQNQLSSRGFENLVPYTSTVSVVATPVMTYGHLEGLINEWNLELEDQEKYFLLQATQVNAWDRTLIENGEMISILHGEVNKVKLDQKRLEQELDFILSEQQELEFLLTYLEEATSNQSGLHYLQDADEERVKTYRLAERIDAQLKQMAQDLKDGVNHLNTFESSADTTDLLHQICRILNAHMESLQWIDRNSDMLRRKVEEVTQVFEDRLHKEHARDVNTAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2J2</accession>
    <name>A0A8I5R2J2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LIM domain containing preferred translocation partner in lipoma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LPP</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell junction</location>
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        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="4">Belongs to the zyxin/ajuba family.</text>
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        <property type="gene ID" value="ENSPANG00000006486.3"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:stress fiber"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LIM1_TRIP6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM2_TRIP6"/>
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    </dbReference>
    <dbReference type="CDD" id="cd09436">
        <property type="entry name" value="LIM3_TRIP6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
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    </dbReference>
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        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
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        <property type="entry name" value="LIPOMA-PREFERRED PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
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    <keyword evidence="11 13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="539"/>
            <end position="598"/>
        </location>
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    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="599"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="660"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="257"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="433"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="737" mass="79880" checksum="C4D10BC53AAB88A4" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R7E9</accession>
    <name>A0A8I5R7E9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
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        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="101" mass="10748" checksum="051C3C31AAFA33E4" modified="2022-05-25" version="1">MPRLEGSSMILAHCKLRLPGSRHSPASASRVAGTTGAHHHAQLIFVFLIDTGFHLVSQDGLDLLTSCDPPASASQSAGITGVSHRARPDMSSFKLNIHLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R9P1</accession>
    <name>A0A8I5R9P1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
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        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R9P1"/>
    <dbReference type="Ensembl" id="ENSPANT00000065992.1">
        <property type="protein sequence ID" value="ENSPANP00000059769.1"/>
        <property type="gene ID" value="ENSPANG00000047197.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="OMA" id="ETMITFF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="111" mass="12150" checksum="62134DB738C9C87E" modified="2022-05-25" version="1">MLETMITFFFFGTESHSVTQAGVQWHDLSSLQLLPPRFKQLFCLSPLVAGITGVHHHTRPIFVFLVETGFHHVGQAGLELLTSGDPPALASQSAGIKGVSHRTRPLSVNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B6CZ49</accession>
    <name>B6CZ49_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TOMT</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="Nat. Genet." volume="40" first="1335" last="1340">
            <title>Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans.</title>
            <authorList>
                <person name="Ahmed Z.M."/>
                <person name="Masmoudi S."/>
                <person name="Kalay E."/>
                <person name="Belyantseva I.A."/>
                <person name="Mosrati M.A."/>
                <person name="Collin R.W.J."/>
                <person name="Riazuddin S."/>
                <person name="Hmani-Aifa M."/>
                <person name="Venselaar H."/>
                <person name="Kawar M.N."/>
                <person name="Tlili A."/>
                <person name="van der Zwaag B."/>
                <person name="Khan S.Y."/>
                <person name="Ayadi L."/>
                <person name="Riazuddin S.A."/>
                <person name="Morell R.J."/>
                <person name="Griffith A.J."/>
                <person name="Charfedine I."/>
                <person name="Caylan R."/>
                <person name="Oostrik J."/>
                <person name="Karaguzel A."/>
                <person name="Ghorbel A."/>
                <person name="Riazuddin S."/>
                <person name="Friedman T.B."/>
                <person name="Ayadi H."/>
                <person name="Kremer H."/>
            </authorList>
            <dbReference type="PubMed" id="18953341"/>
            <dbReference type="DOI" id="10.1038/ng.245"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="6">Brain</tissue>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EU627080">
        <property type="protein sequence ID" value="ACF40890.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B6CZ49"/>
    <dbReference type="Ensembl" id="ENSPANT00000025149.3">
        <property type="protein sequence ID" value="ENSPANP00000005736.1"/>
        <property type="gene ID" value="ENSPANG00000002496.4"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:103877723"/>
    <dbReference type="GeneTree" id="ENSGT00940000161220"/>
    <dbReference type="HOGENOM" id="CLU_095080_1_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002496">
        <property type="expression patterns" value="Expressed in thymus and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B6CZ49">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACF40890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="192" mass="22174" checksum="CF3C0CD24E07AA15" modified="2008-11-25" version="1">MNKRDYMNTSVQEPPLDYSFRSIHIIQDLVNEEPRTGLRPLKRSKSGKSLTQSLWLNNNVLNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQHLGEVNKLAVLPRLRSLTLHGNPMEEEKGYRQYVLCTLPHITTFDFSGVTKADRTTAEVWKRMNIKPKKARIKQNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLS4</accession>
    <name>A0A096MLS4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Barrier-to-autointegration factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BANF1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer. Heterodimerizes with BANF2. Interacts with ANKLE2/LEM4, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A). Binds non-specifically to double-stranded DNA, and is found as a hexamer or dodecamer upon DNA binding. Binds to LEM domain-containing nuclear proteins such as LEMD3/MAN1, TMPO/LAP2 and EMD (emerin). Interacts with ANKLE1 (via LEM domain); the interaction may favor BANF1 dimerization. Interacts with CRX and LMNA (lamin-A). Binds linker histone H1.1 and core histones H3. Interacts with LEMD2 (via LEM domain). Interacts with PARP1; interaction takes place in response to oxidative DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909589.1">
        <property type="nucleotide sequence ID" value="XM_003909540.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MLS4"/>
    <dbReference type="SMR" id="A0A096MLS4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000505"/>
    <dbReference type="Ensembl" id="ENSPANT00000004600.3">
        <property type="protein sequence ID" value="ENSPANP00000000505.1"/>
        <property type="gene ID" value="ENSPANG00000010912.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006364"/>
    <dbReference type="KEGG" id="panu:101006364"/>
    <dbReference type="CTD" id="8815"/>
    <dbReference type="eggNOG" id="KOG4233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018613"/>
    <dbReference type="HOGENOM" id="CLU_167806_0_0_1"/>
    <dbReference type="OMA" id="SKQQGDC"/>
    <dbReference type="OrthoDB" id="9997163at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010912">
        <property type="expression patterns" value="Expressed in pineal body and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140896">
        <property type="term" value="P:cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007084">
        <property type="term" value="P:mitotic nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160049">
        <property type="term" value="P:negative regulation of cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.40:FF:000001">
        <property type="entry name" value="Barrier-to-autointegration factor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF7">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="89" mass="10059" checksum="9A2180A2D284F5D0" modified="2014-11-26" version="1">MTTSQKHRDFVAEPMGEKPVGSLAGIGEVLGKKLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MM30</accession>
    <name>A0A096MM30_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">5-hydroxytryptamine receptor 3A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">5-hydroxytryptamine receptor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Serotonin receptor 3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Serotonin-gated ion channel receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">HTR3A</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo. Interacts with RIC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MM30"/>
    <dbReference type="Ensembl" id="ENSPANT00000008695.3">
        <property type="protein sequence ID" value="ENSPANP00000000642.3"/>
        <property type="gene ID" value="ENSPANG00000014346.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157705"/>
    <dbReference type="HOGENOM" id="CLU_1011799_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014346">
        <property type="expression patterns" value="Expressed in adrenal cortex and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904602">
        <property type="term" value="C:serotonin-activated cation-selective channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022850">
        <property type="term" value="F:serotonin-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140227">
        <property type="term" value="P:serotonin-gated cation-selective signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19011">
        <property type="entry name" value="LGIC_ECD_5-HT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19063">
        <property type="entry name" value="LGIC_TM_5-HT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000020">
        <property type="entry name" value="5-hydroxytryptamine (serotonin) receptor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000017">
        <property type="entry name" value="5-hydroxytryptamine receptor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008132">
        <property type="entry name" value="5HT3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008133">
        <property type="entry name" value="5HT3_rcpt_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049944">
        <property type="entry name" value="LGIC_TM_5-HT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01709">
        <property type="entry name" value="5HT3ARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01708">
        <property type="entry name" value="5HT3RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 27" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 27" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 27" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 27" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342460" description="5-hydroxytryptamine receptor 3A" evidence="27">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="29">
        <location>
            <begin position="47"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="30">
        <location>
            <begin position="260"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000642.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="489" mass="56600" checksum="DF0E2FBDF046786D" modified="2022-05-25" version="3">TRRKLAMLLWVQQALLALLLPRLLAQGEARRSAGLQGRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKFDKSVFMNQGEWELLGVLPDFREFSMESSHYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAIRNHCNHMGGPQDLEKNPRGRCSPPPPPREASLAVRGLLQELSSIRHFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MN84</accession>
    <name>A0A096MN84_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PPA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003899097.1">
        <property type="nucleotide sequence ID" value="XM_003899048.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MN84"/>
    <dbReference type="Ensembl" id="ENSPANT00000023604.3">
        <property type="protein sequence ID" value="ENSPANP00000001096.1"/>
        <property type="gene ID" value="ENSPANG00000001031.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008011"/>
    <dbReference type="KEGG" id="panu:101008011"/>
    <dbReference type="CTD" id="27068"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017004"/>
    <dbReference type="HOGENOM" id="CLU_040684_0_2_1"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001031">
        <property type="expression patterns" value="Expressed in metanephros cortex and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MN84">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000008">
        <property type="entry name" value="Pyrophosphatase (inorganic) 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000013">
        <property type="entry name" value="Pyrophosphatase (inorganic) 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="334" mass="38001" checksum="9A84046180F51B11" modified="2014-11-26" version="1">MSALLRLLRTGAPAAACLRLGTSAGTGPRRAMALYHTEERGQPCSQNYRLFFKDVTGHYISPFHDIPLKVNSKEENGIPTKKARNDEYENLFNMIVEIPRWTNAKMEIATEEPLNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPREKDKSTNCFGDNDPIDVCEIGSKILSCGEVVHVKILGILALIDEGETDWKLIAINVNDPEASKFHDIDDVEKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVLSSPNKENNEEEQVWHFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MN92</accession>
    <name>A0A096MN92_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Docking protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DOK3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOK family. Type A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009207915.3">
        <property type="nucleotide sequence ID" value="XM_009209651.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017815667.2">
        <property type="nucleotide sequence ID" value="XM_017960178.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522512.1">
        <property type="nucleotide sequence ID" value="XM_031666652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MN92"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001104"/>
    <dbReference type="Ensembl" id="ENSPANT00000022880.3">
        <property type="protein sequence ID" value="ENSPANP00000001104.3"/>
        <property type="gene ID" value="ENSPANG00000005512.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101001640"/>
    <dbReference type="KEGG" id="panu:101001640"/>
    <dbReference type="CTD" id="79930"/>
    <dbReference type="eggNOG" id="KOG4047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161724"/>
    <dbReference type="OMA" id="AQHRQEW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005512">
        <property type="expression patterns" value="Expressed in bone marrow and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MN92">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14676">
        <property type="entry name" value="PH_DOK1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01203">
        <property type="entry name" value="PTB_DOK1_DOK2_DOK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000213">
        <property type="entry name" value="Docking protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000347">
        <property type="entry name" value="Docking protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037751">
        <property type="entry name" value="Dok1/2/3_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF42">
        <property type="entry name" value="DOCKING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="4">
        <location>
            <begin position="157"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001104.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="440" mass="47842" checksum="6E7929D4FF06A6E0" modified="2022-05-25" version="3">MDPVETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTSAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKVTQVLYSWPYHFLRKFGSDKGVFSFEAGRRCDSGEGLFAFHTPCAPDLCRAVAEAITRQRERLPELARAQPCPLPRATSLPSLDAPGELREMPPGPEPPTSRRVRLAEPGPQSLPLLLGLEPSDPASGLYASVCKRASGLPRTEHLYENLCVLEASPTPHSGEPERHEGPGGHSPTASPIYHNGEDLSWPSPAHDSSLEAQYRRLLELDEAEGTGRPDPQAGFKAKLVNLLSRERRKGPAPCDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPT5</accession>
    <name>A0A096MPT5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C-type lectin domain family 7 member A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Dendritic cell-associated C-type lectin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CLEC7A</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. Interacts with CD37; this interaction controls CLEC7A-mediated IL-6 production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000001752.3"/>
        <property type="gene ID" value="ENSPANG00000025660.3"/>
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    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161161"/>
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    <dbReference type="OMA" id="NWIIHEK"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025660">
        <property type="expression patterns" value="Expressed in cornea and 46 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:cell surface"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0038187">
        <property type="term" value="F:pattern recognition receptor activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="14" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
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    <sequence length="262" mass="29185" checksum="44F6158C1D7F411C" modified="2022-05-25" version="3">MSIQGLSRTMEYHPDLENLDEDGYTQLHFDSRSNTRIAVVSEKGSCVASPPWRLIAVILGILCLVILVIAVVLGTMAIWRPNSGSNSLENGYFPSRNKENHSQPTQSPLEESVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSPSLNSWDGSKRQCSQLGSNLIKIDSSKELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHMSVIYDQLCSVPSYSICEKKFSMSSGYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRU8</accession>
    <name>A0A096MRU8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BCL2 interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BNIP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900578.1">
        <property type="nucleotide sequence ID" value="XM_003900529.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRU8"/>
    <dbReference type="SMR" id="A0A096MRU8"/>
    <dbReference type="Ensembl" id="ENSPANT00000011258.3">
        <property type="protein sequence ID" value="ENSPANP00000002505.1"/>
        <property type="gene ID" value="ENSPANG00000003761.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001540"/>
    <dbReference type="KEGG" id="panu:101001540"/>
    <dbReference type="CTD" id="662"/>
    <dbReference type="eggNOG" id="ENOG502QUTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014412"/>
    <dbReference type="HOGENOM" id="CLU_105902_0_0_1"/>
    <dbReference type="OMA" id="TEVDTHR"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003761">
        <property type="expression patterns" value="Expressed in ascending colon and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRU8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048763">
        <property type="term" value="F:calcium-induced calcium release activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140208">
        <property type="term" value="P:apoptotic process in response to mitochondrial fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15865">
        <property type="entry name" value="SNARE_SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="228" mass="26162" checksum="6354C31E7337DF31" modified="2014-11-26" version="1">MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLSNQTSWRKANLTCKIAIDNLEKAELLQGGDLLRQRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MS21</accession>
    <name>A0A096MS21_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAU ubiquitin like and ribosomal protein S30 fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAU</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003909640.1">
        <property type="nucleotide sequence ID" value="XM_003909591.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MS21"/>
    <dbReference type="SMR" id="A0A096MS21"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002581"/>
    <dbReference type="Ensembl" id="ENSPANT00000017256.3">
        <property type="protein sequence ID" value="ENSPANP00000002581.1"/>
        <property type="gene ID" value="ENSPANG00000009834.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997750"/>
    <dbReference type="KEGG" id="panu:100997750"/>
    <dbReference type="CTD" id="2197"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007479"/>
    <dbReference type="HOGENOM" id="CLU_010412_5_0_1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
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    <dbReference type="Bgee" id="ENSPANG00000009834">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MS21">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002227">
        <property type="term" value="P:innate immune response in mucosa"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01793">
        <property type="entry name" value="Ubl_FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000114">
        <property type="entry name" value="40S ribosomal protein S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039415">
        <property type="entry name" value="FUBI"/>
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    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="133" mass="14386" checksum="4CDBDAB7B710BF42" modified="2014-11-26" version="1">MQLFVRAQELHTLEVTGQETVAQIKAHVASLEGIAPEDQVVLLAGTPLEDEATLGQCGVEALTTLEVAGRMLGGKVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWA1</accession>
    <name>A0A096MWA1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pannexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PANX1</name>
        <name evidence="14" type="synonym">PANX</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Structural component of the gap junctions and the hemichannels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">S-nitrosylation inhibits channel currents and ATP release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003910603.2">
        <property type="nucleotide sequence ID" value="XM_003910554.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWA1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004157"/>
    <dbReference type="GlyCosmos" id="A0A096MWA1">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000022634.3">
        <property type="protein sequence ID" value="ENSPANP00000004157.2"/>
        <property type="gene ID" value="ENSPANG00000019663.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005908"/>
    <dbReference type="KEGG" id="panu:101005908"/>
    <dbReference type="CTD" id="24145"/>
    <dbReference type="eggNOG" id="ENOG502QT58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153972"/>
    <dbReference type="HOGENOM" id="CLU_050054_1_0_1"/>
    <dbReference type="OMA" id="IPDRFQC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019663">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032059">
        <property type="term" value="C:bleb"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022840">
        <property type="term" value="F:leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005253">
        <property type="term" value="F:monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022829">
        <property type="term" value="F:wide pore channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032730">
        <property type="term" value="P:positive regulation of interleukin-1 alpha production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032731">
        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060907">
        <property type="term" value="P:positive regulation of macrophage cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002931">
        <property type="term" value="P:response to ischemia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039099">
        <property type="entry name" value="Pannexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15759">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15759:SF5">
        <property type="entry name" value="PANNEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-nitrosocysteine" evidence="12">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-nitrosocysteine" evidence="12">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="13">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600990-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600990-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004157.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="426" mass="48045" checksum="A5CB0729E90F1992" modified="2022-05-25" version="2">MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSDSGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSACDLDMRDGACSVPGVAENLGQSLWEISESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGVFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDIVDGKTPMSTETREEQGNQTAELKDMNIDSEIKANNGKKNARQRLLDSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYY9</accession>
    <name>A0A096MYY9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acylneuraminate cytidylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CMP-N-acetylneuraminic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CMAS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11344"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60073"/>
            <dbReference type="ChEBI" id="CHEBI:68671"/>
            <dbReference type="EC" id="2.7.7.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer; the active enzyme is formed by a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CMP-NeuNAc synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.43" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003906150.1">
        <property type="nucleotide sequence ID" value="XM_003906101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYY9"/>
    <dbReference type="Ensembl" id="ENSPANT00000028375.3">
        <property type="protein sequence ID" value="ENSPANP00000005173.3"/>
        <property type="gene ID" value="ENSPANG00000001985.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009685"/>
    <dbReference type="KEGG" id="panu:101009685"/>
    <dbReference type="CTD" id="55907"/>
    <dbReference type="eggNOG" id="ENOG502QQH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004237"/>
    <dbReference type="HOGENOM" id="CLU_042930_0_1_1"/>
    <dbReference type="OMA" id="FHGFVWR"/>
    <dbReference type="OrthoDB" id="10262032at2759"/>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001985">
        <property type="expression patterns" value="Expressed in adrenal medulla and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MYY9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008781">
        <property type="term" value="F:N-acylneuraminate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006055">
        <property type="term" value="P:CMP-N-acetylneuraminate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02513">
        <property type="entry name" value="CMP-NeuAc_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01630">
        <property type="entry name" value="HAD_KDO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000082">
        <property type="entry name" value="N-acylneuraminate cytidylyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000074">
        <property type="entry name" value="N-acylneuraminate cytidylyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050793">
        <property type="entry name" value="CMP-NeuNAc_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21485">
        <property type="entry name" value="HAD SUPERFAMILY MEMBERS CMAS AND KDSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21485:SF3">
        <property type="entry name" value="N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005173.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="434" mass="48451" checksum="FC0B3D37A23CA6FC" modified="2022-05-25" version="3">MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSISDKLAIVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHIFLLMEKVNNSCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0N8</accession>
    <name>A0A096N0N8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAB33B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096N0N8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005826"/>
    <dbReference type="Ensembl" id="ENSPANT00000006794.3">
        <property type="protein sequence ID" value="ENSPANP00000005826.2"/>
        <property type="gene ID" value="ENSPANG00000014740.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157090"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_3_1"/>
    <dbReference type="OMA" id="PLWIEEC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014740">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903434">
        <property type="term" value="P:negative regulation of constitutive secretory pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000156">
        <property type="term" value="P:regulation of retrograde vesicle-mediated transport, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04115">
        <property type="entry name" value="Rab33B_Rab33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000516">
        <property type="entry name" value="RAB33B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041822">
        <property type="entry name" value="Rab33A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005826.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="275" mass="30425" checksum="1A4BC3C83CD68FC3" modified="2022-05-25" version="2">MPHPQRQAEGTCLLSGATKRYIGAGTDLTPEATSLPSLSSLGRVGGMAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNEIILKPEPKPATTCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1L0</accession>
    <name>A0A096N1L0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">KIAA0319 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">KIAA0319L</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009202918.1">
        <property type="nucleotide sequence ID" value="XM_009204654.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202924.1">
        <property type="nucleotide sequence ID" value="XM_009204660.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202931.1">
        <property type="nucleotide sequence ID" value="XM_009204667.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1L0"/>
    <dbReference type="Ensembl" id="ENSPANT00000019703.3">
        <property type="protein sequence ID" value="ENSPANP00000006184.1"/>
        <property type="gene ID" value="ENSPANG00000010535.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000425"/>
    <dbReference type="KEGG" id="panu:101000425"/>
    <dbReference type="CTD" id="79932"/>
    <dbReference type="eggNOG" id="ENOG502QR8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157613"/>
    <dbReference type="HOGENOM" id="CLU_009448_0_0_1"/>
    <dbReference type="OMA" id="AYVIPDE"/>
    <dbReference type="OrthoDB" id="536372at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010535">
        <property type="expression patterns" value="Expressed in pyloric antrum and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1L0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120211">
        <property type="term" value="P:proacrosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019065">
        <property type="term" value="P:receptor-mediated endocytosis of virus by host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010996">
        <property type="term" value="P:response to auditory stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000061">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000258">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000319">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000257">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056502">
        <property type="entry name" value="KIAA0319-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF3">
        <property type="entry name" value="DYSLEXIA-ASSOCIATED PROTEIN KIAA0319-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23620">
        <property type="entry name" value="KIAA0319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23597">
        <property type="entry name" value="KIAA0319_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="MANSC" evidence="11">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="10">
        <location>
            <begin position="523"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115602" checksum="D37163AE3A03D2CB" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2M3</accession>
    <name>A0A096N2M3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Endonuclease 8-like 3</fullName>
            <ecNumber evidence="4">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">DNA glycosylase FPG2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA glycosylase/AP lyase Neil3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Endonuclease VIII-like 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Nei-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">NEIL3</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases. In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003899436.2">
        <property type="nucleotide sequence ID" value="XM_003899387.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N2M3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006567"/>
    <dbReference type="Ensembl" id="ENSPANT00000012049.3">
        <property type="protein sequence ID" value="ENSPANP00000006567.2"/>
        <property type="gene ID" value="ENSPANG00000014727.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010354"/>
    <dbReference type="KEGG" id="panu:101010354"/>
    <dbReference type="CTD" id="55247"/>
    <dbReference type="eggNOG" id="ENOG502QWRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153230"/>
    <dbReference type="HOGENOM" id="CLU_482283_0_0_1"/>
    <dbReference type="OMA" id="GMKGSVM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014727">
        <property type="expression patterns" value="Expressed in testis and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000405">
        <property type="term" value="F:bubble DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="MeNeil3_N"/>
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        <property type="entry name" value="Nei like DNA glycosylase 3"/>
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        <property type="entry name" value="MutM-like, N-terminal"/>
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    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
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        <property type="entry name" value="FPG_cat"/>
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    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
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        <property type="entry name" value="H2TH_FPG"/>
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        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
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    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
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        <property type="entry name" value="Znf_GRF"/>
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        <property type="entry name" value="Znf_RanBP2"/>
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    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
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        <property type="entry name" value="ENDONUCLEASE 8-LIKE 3"/>
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        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
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        <property type="entry name" value="H2TH"/>
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        <property type="entry name" value="Zn_ribbon_GRF"/>
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        <property type="entry name" value="Zn_ribbon_RanBP"/>
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        <property type="entry name" value="H2TH"/>
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        <property type="entry name" value="ZnF_RBZ"/>
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        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
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        <property type="entry name" value="Ran binding protein zinc finger-like"/>
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        <property type="entry name" value="S13-like H2TH domain"/>
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        <property type="entry name" value="ZF_RANBP2_2"/>
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    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
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            <begin position="2"/>
            <end position="134"/>
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            <begin position="244"/>
            <end position="278"/>
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            <begin position="314"/>
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        <location>
            <begin position="504"/>
            <end position="547"/>
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    <feature type="domain" description="GRF-type" evidence="31">
        <location>
            <begin position="551"/>
            <end position="593"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
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            <begin position="406"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="9">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00082506"/>
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    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082922"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00083341"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51066"/>
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        <source>
            <dbReference type="PROSITE" id="PS51068"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
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        </source>
    </evidence>
    <sequence length="602" mass="67031" checksum="FFB1E3AB4EDCE285" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N353</accession>
    <name>A0A096N353_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Ribonuclease H2 subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RNASEH2C</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <property type="entry name" value="RNase_H2_suC"/>
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            <begin position="91"/>
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            <begin position="208"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
    <sequence length="246" mass="26218" checksum="2D872D1E712C8CFF" modified="2018-02-28" version="2">MECGDEAAIERHRVHLRSATLRDAAPVALHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKEVSMGKPDRLRDSGTDDQEESPLERDFDRFIGATASFSHFTLWGLETIPGPDAKVRGALTWPSLAAAVSRGVPSCPRVDGLGSTIGQTKPGGFYWVVRGKRSSLTTLPSMSRRGYSEQLGPSPGLGASLPPCLTSPTVEATPLADSRTGARGLRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N4L3</accession>
    <name>A0A096N4L3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gem nuclear organelle associated protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GEMIN8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003917471.1">
        <property type="nucleotide sequence ID" value="XM_003917422.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195483.1">
        <property type="nucleotide sequence ID" value="XM_009197219.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195484.1">
        <property type="nucleotide sequence ID" value="XM_009197220.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788546.1">
        <property type="nucleotide sequence ID" value="XM_021932854.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788547.1">
        <property type="nucleotide sequence ID" value="XM_021932855.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N4L3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009520"/>
    <dbReference type="Ensembl" id="ENSPANT00000020605.4">
        <property type="protein sequence ID" value="ENSPANP00000009520.1"/>
        <property type="gene ID" value="ENSPANG00000016642.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997101"/>
    <dbReference type="KEGG" id="panu:100997101"/>
    <dbReference type="CTD" id="54960"/>
    <dbReference type="eggNOG" id="ENOG502S7KA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013608"/>
    <dbReference type="HOGENOM" id="CLU_073610_0_0_1"/>
    <dbReference type="OMA" id="QYFAHTE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016642">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238:SF7">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="242" mass="28492" checksum="815E06AEF80C19E6" modified="2014-11-26" version="1">MAAVKASTSKATRPWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFSLPSYFPPALLPQSSYDNQATYPQSFYDHHLAWQDYPCSSSHFGRSGQHPHYSSRIQASTKEDQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLNSYVNADHDLYCNTRRSIEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N6F5</accession>
    <name>A0A096N6F5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TMF-regulated nuclear protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TMF1 regulated nuclear protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">TRNP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>TRNP1 activity co-evolves with cortical folding in mammals.</title>
            <authorList>
                <person name="Kliesmete Z."/>
                <person name="Wange L.E."/>
                <person name="Vieth B."/>
                <person name="Esgleas M."/>
                <person name="Radmer J."/>
                <person name="Huelsmann M."/>
                <person name="Geuder J."/>
                <person name="Richter D."/>
                <person name="Ohnuki M."/>
                <person name="Goetz M."/>
                <person name="Hellmann I."/>
                <person name="Enard W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="MW373538">
        <property type="protein sequence ID" value="QUX37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N6F5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008055"/>
    <dbReference type="Ensembl" id="ENSPANT00000027063.3">
        <property type="protein sequence ID" value="ENSPANP00000008055.2"/>
        <property type="gene ID" value="ENSPANG00000018909.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017418"/>
    <dbReference type="HOGENOM" id="CLU_106336_0_0_1"/>
    <dbReference type="OMA" id="IACGAQQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018909">
        <property type="expression patterns" value="Expressed in amygdala and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021696">
        <property type="term" value="P:cerebellar cortex morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040266">
        <property type="entry name" value="TRNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40714">
        <property type="entry name" value="TMF-REGULATED NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40714:SF1">
        <property type="entry name" value="TMF-REGULATED NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QUX37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008055.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="227" mass="23355" checksum="22BD1ACC3F223117" modified="2018-02-28" version="2">MPGCRISACGPGAQEGTAEPGSPPPPREPMPFSQPPPPTPTLTSTPTPGQSPPLPDAAGASAGAAEGQELQRWRQGASGVAGLAGPGGGSGAAAGTGGRALELAEARRRLLEVEGRRRLVSELESRVLQLHRVFLAAELRLAHRAESLSRLSGGVAQAELYLAAHGSRLKKGQRRGRRGRPPALLASALGLGGCVPWGAGRLRRGHGPEPDSPFRRSPPRGPASPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7H4</accession>
    <name>A0A096N7H4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibroblast growth factor receptor substrate 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FRS2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009179458.1">
        <property type="nucleotide sequence ID" value="XM_009181194.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506473.1">
        <property type="nucleotide sequence ID" value="XM_031650613.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506474.1">
        <property type="nucleotide sequence ID" value="XM_031650614.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506475.1">
        <property type="nucleotide sequence ID" value="XM_031650615.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506476.1">
        <property type="nucleotide sequence ID" value="XM_031650616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N7H4"/>
    <dbReference type="SMR" id="A0A096N7H4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008499"/>
    <dbReference type="Ensembl" id="ENSPANT00000015266.3">
        <property type="protein sequence ID" value="ENSPANP00000008499.3"/>
        <property type="gene ID" value="ENSPANG00000020396.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022137"/>
    <dbReference type="KEGG" id="panu:101022137"/>
    <dbReference type="CTD" id="10818"/>
    <dbReference type="eggNOG" id="KOG4047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157033"/>
    <dbReference type="HOGENOM" id="CLU_022374_0_0_1"/>
    <dbReference type="OMA" id="AHKIDYS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020396">
        <property type="expression patterns" value="Expressed in testis and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005168">
        <property type="term" value="F:neurotrophin TRKA receptor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:anterior/posterior axis specification, embryo"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:gastrulation with mouth forming second"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lens fiber cell development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lens placode formation involved in camera-type eye formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of cardiac muscle cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neuroblast proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:organ induction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Docking_Protein_DOK"/>
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        <property type="entry name" value="IRS_PTB"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF40">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2"/>
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    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
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            <begin position="483"/>
            <end position="508"/>
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            <begin position="122"/>
            <end position="131"/>
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    </feature>
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            <begin position="227"/>
            <end position="240"/>
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        <location>
            <begin position="276"/>
            <end position="286"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="325"/>
            <end position="338"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022707"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51064"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="508" mass="57056" checksum="357E13B5F7B0704A" modified="2022-05-25" version="3">MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESNTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8M0</accession>
    <name>A0A096N8M0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Unconventional myosin-Vb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MYO5B</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017807214.2">
        <property type="nucleotide sequence ID" value="XM_017951725.3"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000008951"/>
    <dbReference type="Ensembl" id="ENSPANT00000018346.4">
        <property type="protein sequence ID" value="ENSPANP00000008951.3"/>
        <property type="gene ID" value="ENSPANG00000022089.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101014744"/>
    <dbReference type="CTD" id="4645"/>
    <dbReference type="GeneTree" id="ENSGT00940000155402"/>
    <dbReference type="HOGENOM" id="CLU_000192_9_1_1"/>
    <dbReference type="OMA" id="KVQDLEX"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022089">
        <property type="expression patterns" value="Expressed in esophagus and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N8M0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd15477">
        <property type="entry name" value="Myo5b_CBD"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin heavy chain"/>
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    <dbReference type="FunFam" id="1.20.5.190:FF:000006">
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.120.720:FF:000016">
        <property type="entry name" value="Myosin VB"/>
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        <property type="entry name" value="Myosin VB"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.5.190:FF:000039">
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
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        <property type="entry name" value="Dilute_dom"/>
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        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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        <property type="entry name" value="Myo5a/b_dom"/>
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        <property type="entry name" value="Myosin_head_motor_dom-like"/>
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        <property type="entry name" value="MYSc_Myo5"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
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    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13140:SF356">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DIL"/>
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        <property type="entry name" value="IQ"/>
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        <property type="entry name" value="Myo5a"/>
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    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
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        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="entry name" value="DIL"/>
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        <property type="entry name" value="IQ"/>
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        <property type="entry name" value="MYSc"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="DILUTE"/>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3_LIKE"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="11 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="22">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="69"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="20">
        <location>
            <begin position="1527"/>
            <end position="1804"/>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="598"/>
            <end position="630"/>
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    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="17">
        <location>
            <begin position="640"/>
            <end position="662"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1094"/>
            <end position="1122"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1168"/>
            <end position="1188"/>
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    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="896"/>
            <end position="947"/>
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    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1203"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1334"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008951.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1849" mass="213761" checksum="97B54926720E6DBF" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9R2</accession>
    <name>A0A096N9R2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyglutamine-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyglutamine tract-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PQBP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003917733.1">
        <property type="nucleotide sequence ID" value="XM_003917684.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195805.1">
        <property type="nucleotide sequence ID" value="XM_009197541.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N9R2"/>
    <dbReference type="SMR" id="A0A096N9R2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009392"/>
    <dbReference type="Ensembl" id="ENSPANT00000017863.3">
        <property type="protein sequence ID" value="ENSPANP00000009392.1"/>
        <property type="gene ID" value="ENSPANG00000013632.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011433"/>
    <dbReference type="KEGG" id="panu:101011433"/>
    <dbReference type="CTD" id="10084"/>
    <dbReference type="eggNOG" id="KOG3427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183102"/>
    <dbReference type="HOGENOM" id="CLU_043596_1_0_1"/>
    <dbReference type="OMA" id="IYHECSK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013632">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N9R2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071598">
        <property type="term" value="C:neuronal ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071360">
        <property type="term" value="P:cellular response to exogenous dsRNA"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of RNA splicing"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="FunFam" id="3.40.30.10:FF:000140">
        <property type="entry name" value="polyglutamine-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF3">
        <property type="entry name" value="POLYGLUTAMINE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="77"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021117"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022588"/>
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            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="265" mass="30426" checksum="68D8256B57706FD6" modified="2014-11-26" version="1">MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRGHEKPDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9V6</accession>
    <name>A0A096N9V6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biorientation of chromosomes in cell division 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BOD1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BOD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900582.2">
        <property type="nucleotide sequence ID" value="XM_003900533.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N9V6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009442"/>
    <dbReference type="Ensembl" id="ENSPANT00000009284.3">
        <property type="protein sequence ID" value="ENSPANP00000009442.3"/>
        <property type="gene ID" value="ENSPANG00000005513.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003156"/>
    <dbReference type="KEGG" id="panu:101003156"/>
    <dbReference type="CTD" id="91272"/>
    <dbReference type="eggNOG" id="ENOG502S57W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154979"/>
    <dbReference type="HOGENOM" id="CLU_139504_0_0_1"/>
    <dbReference type="OMA" id="QISAYKR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005513">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N9V6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071962">
        <property type="term" value="P:mitotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071459">
        <property type="term" value="P:protein localization to chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043244">
        <property type="entry name" value="BOD1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391:SF1">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="5">
        <location>
            <begin position="150"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009442.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="280" mass="29441" checksum="18FD62178692A693" modified="2022-05-25" version="3">MQRPTATPSRARLESSRQFLPRLPQPLVSQGWPSPPPPPPPPPPPSPPPPPPSPPPLPPWGPPPSPPPSPPLHVQGLLSWKRSYYRSPLWARGTAMADGGGGGGTGAVGGGGAGQASAGAATGATGASGGGGPINPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKAAVPAPPPEPEGQDPPAPSQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA88</accession>
    <name>A0A096NA88_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLIT-ROBO Rho GTPase-activating protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rho GTPase-activating protein 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">WAVE-associated Rac GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SRGAP3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021788886.1">
        <property type="nucleotide sequence ID" value="XM_021933194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NA88"/>
    <dbReference type="SMR" id="A0A096NA88"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009592"/>
    <dbReference type="Ensembl" id="ENSPANT00000012626.3">
        <property type="protein sequence ID" value="ENSPANP00000009592.2"/>
        <property type="gene ID" value="ENSPANG00000008856.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012556"/>
    <dbReference type="CTD" id="9901"/>
    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182824"/>
    <dbReference type="HOGENOM" id="CLU_005715_0_0_1"/>
    <dbReference type="OMA" id="MEAFIKX"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008856">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NA88">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07684">
        <property type="entry name" value="F-BAR_srGAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11955">
        <property type="entry name" value="SH3_srGAP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000013">
        <property type="entry name" value="SLIT-ROBO Rho GTPase activating protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000020">
        <property type="entry name" value="SLIT-ROBO Rho GTPase activating protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000005">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
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        <property type="entry name" value="srGAP1/2/3_SH3"/>
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    <dbReference type="InterPro" id="IPR049581">
        <property type="entry name" value="SrGAP3_F-BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3_1"/>
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        <property type="entry name" value="FCH"/>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 10 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="14">
        <location>
            <begin position="506"/>
            <end position="694"/>
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    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="744"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="471"/>
            <end position="493"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="809"/>
            <end position="847"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="861"/>
            <end position="911"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="926"/>
            <end position="950"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1047"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="359"/>
            <end position="386"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="926"/>
            <end position="936"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="937"/>
            <end position="947"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00073505"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078662"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009592.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124548" checksum="D7D39C519F00A227" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NBF5</accession>
    <name>A0A096NBF5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP6V1H</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Clathrin-coated vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase H subunit family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003902753.3"/>
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    <dbReference type="SMR" id="A0A096NBF5"/>
    <dbReference type="Ensembl" id="ENSPANT00000006033.4">
        <property type="protein sequence ID" value="ENSPANP00000010096.1"/>
        <property type="gene ID" value="ENSPANG00000015126.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101018105"/>
    <dbReference type="KEGG" id="panu:101018105"/>
    <dbReference type="CTD" id="51606"/>
    <dbReference type="GeneTree" id="ENSGT00390000003289"/>
    <dbReference type="HOGENOM" id="CLU_025709_2_0_1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015126">
        <property type="expression patterns" value="Expressed in putamen and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NBF5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="9">
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            <begin position="349"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="483" mass="55962" checksum="DC913E6D467B201F" modified="2014-11-26" version="1">MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARRSKNTAWPYFLPMLNRQDPFTVYMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NE24</accession>
    <name>A0A096NE24_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 3 regulatory subunit B, alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PPP3R1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NE24"/>
    <dbReference type="SMR" id="A0A096NE24"/>
    <dbReference type="Ensembl" id="ENSPANT00000002868.3">
        <property type="protein sequence ID" value="ENSPANP00000011132.1"/>
        <property type="gene ID" value="ENSPANG00000024026.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156530"/>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024026">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NE24">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="170" mass="19300" checksum="C904715DC0386056" modified="2014-11-26" version="1">MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NE53</accession>
    <name>A0A096NE53_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Scaffold protein ILK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ILK-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ILK-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Inactive integrin-linked kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">p59ILK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ILK</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021781869.1">
        <property type="nucleotide sequence ID" value="XM_021926177.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021781870.1">
        <property type="nucleotide sequence ID" value="XM_021926178.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NE53"/>
    <dbReference type="SMR" id="A0A096NE53"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011162"/>
    <dbReference type="Ensembl" id="ENSPANT00000016301.3">
        <property type="protein sequence ID" value="ENSPANP00000011162.3"/>
        <property type="gene ID" value="ENSPANG00000023648.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103877691"/>
    <dbReference type="CTD" id="3611"/>
    <dbReference type="eggNOG" id="KOG0195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155956"/>
    <dbReference type="HOGENOM" id="CLU_000288_7_5_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023648">
        <property type="expression patterns" value="Expressed in aorta and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NE53">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14057">
        <property type="entry name" value="PK_ILK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000187">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000245">
        <property type="entry name" value="Integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035692">
        <property type="entry name" value="PK_ILK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="193"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011162.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="452" mass="51419" checksum="E37DC2AD5311A1C2" modified="2022-05-25" version="3">MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFV1</accession>
    <name>A0A096NFV1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tumor-associated calcium signal transducer 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TACSTD2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May function as a growth factor receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPCAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NFV1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011805"/>
    <dbReference type="Ensembl" id="ENSPANT00000000517.3">
        <property type="protein sequence ID" value="ENSPANP00000011805.2"/>
        <property type="gene ID" value="ENSPANG00000020602.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018245"/>
    <dbReference type="HOGENOM" id="CLU_075326_0_0_1"/>
    <dbReference type="OMA" id="YDPDCDH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020602">
        <property type="expression patterns" value="Expressed in cornea and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000738">
        <property type="term" value="P:positive regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000008">
        <property type="entry name" value="tumor-associated calcium signal transducer 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049420">
        <property type="entry name" value="EPCAM-Trop-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043406">
        <property type="entry name" value="EPCAM/Trop-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041630">
        <property type="entry name" value="EpCAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14168">
        <property type="entry name" value="TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14168:SF5">
        <property type="entry name" value="TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21283">
        <property type="entry name" value="EPCAM-Trop-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18635">
        <property type="entry name" value="EpCAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325877" description="Tumor-associated calcium signal transducer 2" evidence="13">
        <location>
            <begin position="32"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011805.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="324" mass="35785" checksum="177C3B08353249FC" modified="2022-05-25" version="2">MARGPGLAPPPLRLPLLLLLLLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGVAVDCSTLTSKCLLLKARMSAPKNARTLVRPNEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDVKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGVAVLVITNRRKSGKYKKVEIKELGELRKEPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGY8</accession>
    <name>A0A096NGY8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteoglycan 3, pro eosinophil major basic protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRG3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003909911.2">
        <property type="nucleotide sequence ID" value="XM_003909862.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGY8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012234"/>
    <dbReference type="Ensembl" id="ENSPANT00000003151.3">
        <property type="protein sequence ID" value="ENSPANP00000012234.2"/>
        <property type="gene ID" value="ENSPANG00000016978.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023811"/>
    <dbReference type="KEGG" id="panu:101023811"/>
    <dbReference type="CTD" id="10394"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039859"/>
    <dbReference type="HOGENOM" id="CLU_107200_1_0_1"/>
    <dbReference type="OMA" id="FCWTDGS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016978">
        <property type="expression patterns" value="Expressed in bone marrow and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03598">
        <property type="entry name" value="CLECT_EMBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000090">
        <property type="entry name" value="Proteoglycan 2, bone marrow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033816">
        <property type="entry name" value="EMBP_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002352">
        <property type="entry name" value="Eosinophil_major_basic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050976">
        <property type="entry name" value="Snaclec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991:SF40">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00770">
        <property type="entry name" value="EMAJORBASICP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213797" evidence="4">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="110"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012234.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="225" mass="25368" checksum="0AEE0967A313DE4A" modified="2022-05-25" version="2">MQRLLFLPVLLLGTVSALHLENDVPSLESLETGADLGQDLASSREQERDLALTEEVTQAEGKEVKASACQDTFEDEEAMESDPAALDKDFQCPREEDIVEVQGSPRCKACHYLLVRTPTTFANAQNVCSKCYRGNLVSIHNFNFNYRIQRHASTTNQAQVWIGGILRGWFLWKRFCWTDGSHWNFAYWSSGQPGNGRGCCVALCTKGGYWRRAKCNKQLPFVCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLD5</accession>
    <name>A0A096NLD5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">CREBBP</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61996"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
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            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
            <dbReference type="ChEBI" id="CHEBI:231528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:61997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
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            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
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            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
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        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMK2</accession>
    <name>A0A096NMK2_PAPAN</name>
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            <fullName evidence="7">Transmembrane protein 219</fullName>
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        <name evidence="7" type="primary">TMEM219</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
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                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
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                <person name="Lara F.L."/>
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                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
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                <person name="Munidasa M.M."/>
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                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009197124.1">
        <property type="nucleotide sequence ID" value="XM_009198860.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197125.1">
        <property type="nucleotide sequence ID" value="XM_009198861.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009197126.1">
        <property type="nucleotide sequence ID" value="XM_009198862.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788976.1">
        <property type="nucleotide sequence ID" value="XM_021933284.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NMK2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014211"/>
    <dbReference type="Ensembl" id="ENSPANT00000009974.3">
        <property type="protein sequence ID" value="ENSPANP00000014211.2"/>
        <property type="gene ID" value="ENSPANG00000016358.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003168"/>
    <dbReference type="KEGG" id="panu:101003168"/>
    <dbReference type="CTD" id="124446"/>
    <dbReference type="eggNOG" id="ENOG502S30C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153883"/>
    <dbReference type="HOGENOM" id="CLU_2145052_0_0_1"/>
    <dbReference type="OMA" id="TCYSLNF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016358">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039493">
        <property type="entry name" value="TMEM248/TMEM219"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039587">
        <property type="entry name" value="TMEM248/TMEM219_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002:SF6">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 248-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14940">
        <property type="entry name" value="TMEM219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM248/TMEM219" evidence="6">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014211.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="240" mass="25856" checksum="7A5B18C2B0C9135E" modified="2018-02-28" version="2">MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDSPERNKTRIFQATVLGSQMGLKGSYAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRM4</accession>
    <name>A0A096NRM4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protease-associated domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protease-associated domain-containing protein of 21 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRADC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in the modulation of physical activity and adiposity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NRM4"/>
    <dbReference type="SMR" id="A0A096NRM4"/>
    <dbReference type="Ensembl" id="ENSPANT00000015141.3">
        <property type="protein sequence ID" value="ENSPANP00000015694.1"/>
        <property type="gene ID" value="ENSPANG00000010036.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009837"/>
    <dbReference type="HOGENOM" id="CLU_084006_2_0_1"/>
    <dbReference type="OMA" id="ELMQPPW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010036">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NRM4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02127">
        <property type="entry name" value="PA_hPAP21_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000017">
        <property type="entry name" value="Protease-associated domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037323">
        <property type="entry name" value="PRADC1-like_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922654" description="Protease-associated domain-containing protein 1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="65"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="188" mass="21042" checksum="372F16BCDF06CAE9" modified="2014-11-26" version="1">MVPGAAGWCCLVLWLPACVAAHGFRIHDYLYFQVLSPGDIRYIFTATPAKDFGGIFHTRYEQIHLVPAEPPEACGELSNGFFIQDQIALVERGGCSFLSKTRVVQEHGGRAVIISDNAVDNDSFYVEMIQDSTQRTADIPALFLLGRDGYMIRRSLEQHGLPWAIISIPVNVTSIPTFELLQPPWTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRZ2</accession>
    <name>A0A096NRZ2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LSM6</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NRZ2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015812"/>
    <dbReference type="Ensembl" id="ENSPANT00000022895.3">
        <property type="protein sequence ID" value="ENSPANP00000015812.2"/>
        <property type="gene ID" value="ENSPANG00000006552.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154978"/>
    <dbReference type="HOGENOM" id="CLU_076902_7_4_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006552">
        <property type="expression patterns" value="Expressed in ileum and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015812.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="105" mass="11482" checksum="EACD7A95E44C99A6" modified="2022-05-25" version="2">MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNDEVSPCCPGWSVVVQSQLTAASASQAQEILPPQPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NT56</accession>
    <name>A0A096NT56_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trinucleotide repeat-containing gene 6C protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TNRC6C</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GW182 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000028887.3">
        <property type="protein sequence ID" value="ENSPANP00000016227.3"/>
        <property type="gene ID" value="ENSPANG00000019994.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157598"/>
    <dbReference type="HOGENOM" id="CLU_001298_3_0_1"/>
    <dbReference type="OMA" id="TGHWNAP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019994">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NT56">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTP1</accession>
    <name>A0A096NTP1_PAPAN</name>
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        <recommendedName>
            <fullName evidence="10">Essential for reactive oxygen species protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="primary">CYBC1</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the CYBC1 family.</text>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cybc1"/>
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        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837:SF3">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF15169">
        <property type="entry name" value="Cybc1_Eros"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016412.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="323" mass="34943" checksum="30AC082C82887CD9" modified="2022-05-25" version="2">MLAAPLPTPEVREVPPPKVGSAPLQSRKSARPRPCRFASLCCRAGTAVLSVGGWAGWAPHVLPAPCRASRHPGAHSGRGLRPGPACRLLRVPPCPSRAASRLFRGRLATAAGASSTRTKKRALGPSSCRDWGCLLGMYLQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFDKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLHDVRDVSVEEEKVRYFGKGYMVVLRLATGFSHPLTQSAVMGHRSDVEAIAKLITSFLELHCLESPTELSQSSDSEAGDPGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NU98</accession>
    <name>A0A096NU98_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Potassium voltage-gated channel subfamily C member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KCNC1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003910211.1">
        <property type="nucleotide sequence ID" value="XM_003910162.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NU98"/>
    <dbReference type="SMR" id="A0A096NU98"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016622"/>
    <dbReference type="Ensembl" id="ENSPANT00000015358.3">
        <property type="protein sequence ID" value="ENSPANP00000016622.2"/>
        <property type="gene ID" value="ENSPANG00000015328.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009265"/>
    <dbReference type="KEGG" id="panu:101009265"/>
    <dbReference type="CTD" id="3746"/>
    <dbReference type="eggNOG" id="KOG3713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156912"/>
    <dbReference type="HOGENOM" id="CLU_011722_4_3_1"/>
    <dbReference type="OMA" id="QTQSWAL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015328">
        <property type="expression patterns" value="Expressed in cerebellum and 26 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030673">
        <property type="term" value="C:axolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18414">
        <property type="entry name" value="BTB_KCNC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000011">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000014">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily C member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005403">
        <property type="entry name" value="K_chnl_volt-dep_Kv3.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF87">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01581">
        <property type="entry name" value="KV31CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="21">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016622.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="585" mass="65871" checksum="0255A80C2EBAA2D4" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NW45</accession>
    <name>A0A096NW45_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exosomal polycystin 1 interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EPCIP</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096NW45"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017270"/>
    <dbReference type="Ensembl" id="ENSPANT00000021337.3">
        <property type="protein sequence ID" value="ENSPANP00000017270.2"/>
        <property type="gene ID" value="ENSPANG00000017134.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S2I2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016499"/>
    <dbReference type="HOGENOM" id="CLU_079917_0_0_1"/>
    <dbReference type="OMA" id="SRWNSEM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017134">
        <property type="expression patterns" value="Expressed in pituitary gland and 36 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140494">
        <property type="term" value="C:migrasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160040">
        <property type="term" value="P:mitocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029250">
        <property type="entry name" value="ECPIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35658:SF1">
        <property type="entry name" value="CHROMOSOME 21 OPEN READING FRAME 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35658">
        <property type="entry name" value="RCG58666, ISOFORM CRA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15137">
        <property type="entry name" value="ECPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017270.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="266" mass="30257" checksum="920D7803AB82D7D9" modified="2018-02-28" version="2">CRLNQLSSQGEGSVARQRSVEWRGKASRWNSEMTACRHQKSGRTYRRQPCTELRTCNNNSALGVFALNCFTRGQKNSTLIFTKENTIRNCSCSADIRDCDYSLANLMCSCKTVLPLAVGRTSYNGHLTIWFTDTSALGRLLNFTLVQDLKLSLCSANTLPTEYLAICGLQRLRINMEAKHPFPEQSLLIHSAGDSDSREKPMWLHKGWQPCMYISFLDMALFNRDSSLKSYSIENVTSIANNFPDFSYFKTFPMPSHKSYVVTFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWW1</accession>
    <name>A0A096NWW1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratinocyte associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KRTCAP3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908474.1">
        <property type="nucleotide sequence ID" value="XM_003908425.5"/>
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        <property type="nucleotide sequence ID" value="XM_009183889.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWW1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017547"/>
    <dbReference type="Ensembl" id="ENSPANT00000024971.3">
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        <property type="gene ID" value="ENSPANG00000009387.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004845"/>
    <dbReference type="KEGG" id="panu:101004845"/>
    <dbReference type="CTD" id="200634"/>
    <dbReference type="eggNOG" id="ENOG502QWFA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004700"/>
    <dbReference type="HOGENOM" id="CLU_089663_0_0_1"/>
    <dbReference type="OMA" id="CKWQENV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009387">
        <property type="expression patterns" value="Expressed in ascending colon and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020977">
        <property type="entry name" value="Beta-casein-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12304">
        <property type="entry name" value="BCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="240" mass="25607" checksum="AE0F56C8BB2A4339" modified="2014-11-26" version="1">MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTTANVISVGSGLLSVSVGLVALLASRNLLRPPLHWALLVLALVNLLLSAACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAALSGYCCVAALTLRGVGPCRKEGLQGQLEEMIELESPKHKRQENEQLLDESQEIQASQRSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXB1</accession>
    <name>A0A096NXB1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="3 12">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RABGGTA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_003901688.1">
        <property type="nucleotide sequence ID" value="XM_003901639.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXB1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017705"/>
    <dbReference type="Ensembl" id="ENSPANT00000011785.3">
        <property type="protein sequence ID" value="ENSPANP00000017705.2"/>
        <property type="gene ID" value="ENSPANG00000023991.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021872"/>
    <dbReference type="KEGG" id="panu:101021872"/>
    <dbReference type="CTD" id="5875"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075121"/>
    <dbReference type="HOGENOM" id="CLU_031996_3_2_1"/>
    <dbReference type="OMA" id="CAWHHRC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023991">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1130:FF:000001">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000138">
        <property type="entry name" value="geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036254">
        <property type="entry name" value="RabGGT_asu_insert-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009087">
        <property type="entry name" value="RabGGT_asu_insert-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07711">
        <property type="entry name" value="RabGGT_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49594">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 12" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rab geranylgeranyltransferase alpha subunit insert-domain" evidence="13">
        <location>
            <begin position="245"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017705.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="567" mass="65009" checksum="38A7DA032F66170E" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXH3</accession>
    <name>A0A096NXH3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannosidase beta like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MANBAL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0239 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009214418.1">
        <property type="nucleotide sequence ID" value="XM_009216154.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXH3"/>
    <dbReference type="SMR" id="A0A096NXH3"/>
    <dbReference type="Ensembl" id="ENSPANT00000026796.3">
        <property type="protein sequence ID" value="ENSPANP00000017767.1"/>
        <property type="gene ID" value="ENSPANG00000009619.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026469"/>
    <dbReference type="KEGG" id="panu:101026469"/>
    <dbReference type="CTD" id="63905"/>
    <dbReference type="eggNOG" id="ENOG502S6QI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003422"/>
    <dbReference type="HOGENOM" id="CLU_189363_0_0_1"/>
    <dbReference type="OMA" id="KSYEVET"/>
    <dbReference type="OrthoDB" id="10040809at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009619">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NXH3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009621">
        <property type="entry name" value="UPF0239"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14409">
        <property type="entry name" value="MANNOSIDASE, BETA A, LYSOSOMAL-LIKE, MANBAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14409:SF2">
        <property type="entry name" value="PROTEIN MANBAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06783">
        <property type="entry name" value="UPF0239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="85" mass="9467" checksum="8EB01B680C9C06A9" modified="2014-11-26" version="1">MASDLDFSPPEVPEPTFLENLLRYGLFLGAIFQLICVLAIIVPIPKSHEAEAEPSEPRSAEVTRKPKAAVPSVNKRPKKETKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYE4</accession>
    <name>A0A096NYE4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Baculoviral IAP repeat containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BIRC3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NYE4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018107"/>
    <dbReference type="Ensembl" id="ENSPANT00000011908.3">
        <property type="protein sequence ID" value="ENSPANP00000018107.3"/>
        <property type="gene ID" value="ENSPANG00000018870.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154175"/>
    <dbReference type="HOGENOM" id="CLU_016347_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018870">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060546">
        <property type="term" value="P:negative regulation of necroptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070424">
        <property type="term" value="P:regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039535">
        <property type="term" value="P:regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034121">
        <property type="term" value="P:regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd08329">
        <property type="entry name" value="CARD_BIRC2_BIRC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14394">
        <property type="entry name" value="UBA_BIRC2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000005">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000006">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000010">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000012">
        <property type="entry name" value="baculoviral IAP repeat-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000035">
        <property type="entry name" value="baculoviral IAP repeat-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048875">
        <property type="entry name" value="BIRC2-3-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041933">
        <property type="entry name" value="BIRC2/BIRC3_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF178">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21290">
        <property type="entry name" value="UBA_BIRC2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CARD" evidence="14">
        <location>
            <begin position="439"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018107.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="604" mass="68064" checksum="7017E8D0DBD3B32B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0B2</accession>
    <name>A0A096P0B2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Solute carrier family 5 member 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC5A6</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73379"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73371"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73375"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with PDZD11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908451.2">
        <property type="nucleotide sequence ID" value="XM_003908402.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182117.2">
        <property type="nucleotide sequence ID" value="XM_009183853.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182118.2">
        <property type="nucleotide sequence ID" value="XM_009183854.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182120.2">
        <property type="nucleotide sequence ID" value="XM_009183856.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182122.2">
        <property type="nucleotide sequence ID" value="XM_009183858.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182123.2">
        <property type="nucleotide sequence ID" value="XM_009183859.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182124.2">
        <property type="nucleotide sequence ID" value="XM_009183860.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P0B2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018787"/>
    <dbReference type="Ensembl" id="ENSPANT00000013804.3">
        <property type="protein sequence ID" value="ENSPANP00000018787.2"/>
        <property type="gene ID" value="ENSPANG00000011330.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997740"/>
    <dbReference type="KEGG" id="panu:100997740"/>
    <dbReference type="CTD" id="8884"/>
    <dbReference type="GeneTree" id="ENSGT00940000155731"/>
    <dbReference type="HOGENOM" id="CLU_018808_11_1_1"/>
    <dbReference type="OMA" id="GWWGMRR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011330">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P0B2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015111">
        <property type="term" value="F:iodide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140161">
        <property type="term" value="F:monocarboxylate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015498">
        <property type="term" value="F:pantothenate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008523">
        <property type="term" value="F:sodium-dependent multivitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006768">
        <property type="term" value="P:biotin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904200">
        <property type="term" value="P:iodide transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150104">
        <property type="term" value="P:transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11504">
        <property type="entry name" value="SLC5sbd_SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000011">
        <property type="entry name" value="sodium-dependent multivitamin transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
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        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00052729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00058802"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="636" mass="68899" checksum="53F23E9E74897213" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0R0</accession>
    <name>A0A096P0R0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multiple epidermal growth factor-like domains protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Epidermal growth factor-like protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MEGF9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="Ensembl" id="ENSPANT00000027634.4">
        <property type="protein sequence ID" value="ENSPANP00000018935.2"/>
        <property type="gene ID" value="ENSPANG00000025814.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101005337"/>
    <dbReference type="KEGG" id="panu:101005337"/>
    <dbReference type="CTD" id="1955"/>
    <dbReference type="eggNOG" id="KOG0994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161177"/>
    <dbReference type="OMA" id="GTCHTDS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025814">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048514">
        <property type="term" value="P:blood vessel morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035176144" description="Multiple epidermal growth factor-like domains protein 9" evidence="15">
        <location>
            <begin position="35"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018935.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="600" mass="62910" checksum="00DA422A566CCAD5" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0Y9</accession>
    <name>A0A096P0Y9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Frizzled-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">FZD6</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="22">Interacts with LMBR1L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918873.1">
        <property type="nucleotide sequence ID" value="XM_003918824.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810110.1">
        <property type="nucleotide sequence ID" value="XM_017954621.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P0Y9"/>
    <dbReference type="SMR" id="A0A096P0Y9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019014"/>
    <dbReference type="Ensembl" id="ENSPANT00000027269.4">
        <property type="protein sequence ID" value="ENSPANP00000019014.1"/>
        <property type="gene ID" value="ENSPANG00000025725.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100999712"/>
    <dbReference type="KEGG" id="panu:100999712"/>
    <dbReference type="CTD" id="8323"/>
    <dbReference type="GeneTree" id="ENSGT00940000158485"/>
    <dbReference type="HOGENOM" id="CLU_007873_4_0_1"/>
    <dbReference type="OMA" id="FLKHNNR"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025725">
        <property type="expression patterns" value="Expressed in thyroid gland and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033278">
        <property type="term" value="P:cell proliferation in midbrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035880">
        <property type="term" value="P:embryonic nail plate morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048105">
        <property type="term" value="P:establishment of body hair planar orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001942">
        <property type="term" value="P:hair follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904693">
        <property type="term" value="P:midbrain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060071">
        <property type="term" value="P:Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15032">
        <property type="entry name" value="7tmF_FZD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07450">
        <property type="entry name" value="CRD_FZ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000036">
        <property type="entry name" value="frizzled-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000014">
        <property type="entry name" value="frizzled-6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041770">
        <property type="entry name" value="FZ6_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026543">
        <property type="entry name" value="FZD6_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF75">
        <property type="entry name" value="FRIZZLED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="17 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 26" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0807">Transducer</keyword>
    <keyword evidence="10 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001923533" description="Frizzled-6" evidence="26">
        <location>
            <begin position="19"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="27">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="28">
        <location>
            <begin position="195"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="588"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="706" mass="79321" checksum="F1868C519B6BDE87" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3H4</accession>
    <name>A0A096P3H4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FERM domain containing 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FRMD4A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003903450.1">
        <property type="nucleotide sequence ID" value="XM_003903401.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P3H4"/>
    <dbReference type="SMR" id="A0A096P3H4"/>
    <dbReference type="Ensembl" id="ENSPANT00000021542.4">
        <property type="protein sequence ID" value="ENSPANP00000019899.2"/>
        <property type="gene ID" value="ENSPANG00000023342.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100999474"/>
    <dbReference type="KEGG" id="panu:100999474"/>
    <dbReference type="CTD" id="55691"/>
    <dbReference type="eggNOG" id="KOG3529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230354"/>
    <dbReference type="OMA" id="HILTWRT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023342">
        <property type="expression patterns" value="Expressed in cornea and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P3H4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13191">
        <property type="entry name" value="FERM_C_FRMD4A_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17200">
        <property type="entry name" value="FERM_F1_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERM domain containing 4A"/>
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    </dbReference>
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    <dbReference type="FunFam" id="2.30.29.30:FF:000022">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041785">
        <property type="entry name" value="FRMD4A/B_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF3">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
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                <person name="Garcia-Iii R.G."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Hollins B.H."/>
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                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Tang L.-Y.T."/>
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                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
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                <person name="Vattathil S.V."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
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                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
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        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="5">Belongs to the CASC3 family.</text>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P6C7</accession>
    <name>A0A096P6C7_PAPAN</name>
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        <recommendedName>
            <fullName evidence="13">Transmembrane ascorbate-dependent reductase CYB561</fullName>
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        <alternativeName>
            <fullName evidence="14">Cytochrome b-561</fullName>
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        <alternativeName>
            <fullName evidence="15">Cytochrome b561</fullName>
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        <name evidence="20" type="primary">CYB561</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>monodehydro-L-ascorbate radical(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + L-ascorbate(out)</text>
            <dbReference type="Rhea" id="RHEA:66524"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66525"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Secretory vesicle</location>
            <location evidence="12">Chromaffin granule membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P6C7"/>
    <dbReference type="Ensembl" id="ENSPANT00000012977.3">
        <property type="protein sequence ID" value="ENSPANP00000020902.2"/>
        <property type="gene ID" value="ENSPANG00000021047.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183197"/>
    <dbReference type="HOGENOM" id="CLU_069712_1_1_1"/>
    <dbReference type="OMA" id="LHFRGGM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Bgee" id="ENSPANG00000021047">
        <property type="expression patterns" value="Expressed in esophagus and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P6C7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:ascorbate homeostasis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Cyt_b561_CYB561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="19">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024231"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045973"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="258" mass="28336" checksum="CCD316E31FA4582D" modified="2018-02-28" version="2">MSSVCLSMEGGAAASTPAALPYYVAFSQLLGLTLVAMTGAWLGLYRGGIAWESDLQFNAHPLCMVIGLVFLQGDALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGAPFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFNLGDKYSAFEPEGVLANVLGLLLACFGGVVLYILTRADWKRPSQAEEQALSMDFKTLTEGDSPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWE4</accession>
    <name>A0A0A0MWE4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EP300 interacting inhibitor of differentiation 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EID2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003915567.1">
        <property type="nucleotide sequence ID" value="XM_003915518.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWE4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009320"/>
    <dbReference type="Ensembl" id="ENSPANT00000016980.3">
        <property type="protein sequence ID" value="ENSPANP00000009320.1"/>
        <property type="gene ID" value="ENSPANG00000003943.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009986"/>
    <dbReference type="KEGG" id="panu:101009986"/>
    <dbReference type="CTD" id="163126"/>
    <dbReference type="eggNOG" id="ENOG502RU2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154796"/>
    <dbReference type="HOGENOM" id="CLU_102589_0_0_1"/>
    <dbReference type="OMA" id="FDAEYMR"/>
    <dbReference type="OrthoDB" id="9838394at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003943">
        <property type="expression patterns" value="Expressed in pineal body and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060392">
        <property type="term" value="P:negative regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007181">
        <property type="term" value="P:transforming growth factor beta receptor complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033258">
        <property type="entry name" value="EID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15556:SF3">
        <property type="entry name" value="EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15556">
        <property type="entry name" value="EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="236" mass="25210" checksum="D2CCC4E6392BE3CE" modified="2015-01-07" version="1">MSNLPADSSVPQTSAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPMPAAREGRMAAARGAPAAAARGAPVAAAAVARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYLRLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTFTIALTASEVINPLIEELGCDKFINRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LCY2</accession>
    <name>A0A2I3LCY2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat containing 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LRRC34</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LCY2"/>
    <dbReference type="Ensembl" id="ENSPANT00000044783.2">
        <property type="protein sequence ID" value="ENSPANP00000021315.2"/>
        <property type="gene ID" value="ENSPANG00000007622.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156456"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007622">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LCY2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021315.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="432" mass="47876" checksum="73E691E0D2E6D2FB" modified="2022-05-25" version="2">MAAQPPRPVGERSMGSPREADRAPARSPAWAPTQARTPGAALVGQRESPESGLQEHYSNLCMEKSQKINPFILRILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSRILKNCLYINGLDVGYNLLSDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTSGESYDHSSNAGFALVPVGQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LJV2</accession>
    <name>A0A2I3LJV2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Immunoglobulin-like and fibronectin type III domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with FLNC. Interacts with KY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LJV2"/>
    <dbReference type="Ensembl" id="ENSPANT00000058682.2">
        <property type="protein sequence ID" value="ENSPANP00000023732.2"/>
        <property type="gene ID" value="ENSPANG00000009052.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162073"/>
    <dbReference type="OMA" id="VGRNDWE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009052">
        <property type="expression patterns" value="Expressed in gastrocnemius and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001231">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001267">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000617">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001232">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001389">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001435">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001525">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001097">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:001401">
        <property type="entry name" value="immunoglobulin-like and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:001438">
        <property type="entry name" value="Immunoglobulin-like and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000060">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040849">
        <property type="entry name" value="MyBP-C_THB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF138">
        <property type="entry name" value="IMMUNOGLOBULIN-LIKE AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18362">
        <property type="entry name" value="THB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="454"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="646"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="746"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="847"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1151"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023732.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1251" mass="137634" checksum="2339803A0531B124" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LSB7</accession>
    <name>A0A2I3LSB7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Chromatin-modifying protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LSB7"/>
    <dbReference type="Ensembl" id="ENSPANT00000048006.2">
        <property type="protein sequence ID" value="ENSPANP00000026360.2"/>
        <property type="gene ID" value="ENSPANG00000035598.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074817"/>
    <dbReference type="OMA" id="CICFVAV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035598">
        <property type="expression patterns" value="Expressed in renal medulla and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904930">
        <property type="term" value="C:amphisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046761">
        <property type="term" value="P:viral budding from plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026360.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="166" mass="19140" checksum="33BDB3137DD223ED" modified="2022-05-25" version="2">MNNLHYRKCKTAGFRFWFCSSVWVSSRPLKMNRLFGKAKPKALPPSLTDCIGTNMVKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAYKQVKIDQIEDLQDQLEDMMEDANEIQEALSRSYGTPELDEDDLEAGWSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LXV2</accession>
    <name>A0A2I3LXV2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031516320.1">
        <property type="nucleotide sequence ID" value="XM_031660460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LXV2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000028291"/>
    <dbReference type="Ensembl" id="ENSPANT00000037560.2">
        <property type="protein sequence ID" value="ENSPANP00000028291.2"/>
        <property type="gene ID" value="ENSPANG00000038508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101002531"/>
    <dbReference type="KEGG" id="panu:101002531"/>
    <dbReference type="GeneTree" id="ENSGT01150000286923"/>
    <dbReference type="OMA" id="CAKMVIG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028291.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="312" mass="35522" checksum="B94E47621238F104" modified="2022-05-25" version="2">MEKWNHTSNDFILLGLLPPNQTGIFLLCLIILIFFLASVGNSAMIHLIHVDPRLHTPMYFLLSQLSLMDLMHISTTVPKMAHDFLSGQKGISFLGCGVQSFFFLTMAGSEGLLLTSMAYDRYVAICHPLHYPLRMSKMMCMKMIGGSWTLGSINSLAHTVYALHIPYCRTRAIDHFFCDVPAMLLIACTDTWVYEYMVFVSTSLYLLFPFIGITASYGRVLFAVYHMHSKEGRKKALSTISTHLTVVIFYYAPFLYTYLRPRNLRSPAEDKILAVFYTILTPILNPIIYSLRNKEVLGAMTRVFGIFSFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LYK3</accession>
    <name>A0A2I3LYK3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DOCK9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000058635.2">
        <property type="protein sequence ID" value="ENSPANP00000028547.2"/>
        <property type="gene ID" value="ENSPANG00000017575.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155972"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017575">
        <property type="expression patterns" value="Expressed in esophagus and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LYK3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11698">
        <property type="entry name" value="DHR2_DOCK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000016">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000015">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.40.410:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
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    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
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    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
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    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
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    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
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    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF77">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="651"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1616"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028547.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2081" mass="237926" checksum="B703A150936CAE64" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LZS2</accession>
    <name>A0A2I3LZS2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox protein engrailed-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EN1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Engrailed homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909249.1">
        <property type="nucleotide sequence ID" value="XM_003909200.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LZS2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000028957"/>
    <dbReference type="Ensembl" id="ENSPANT00000042814.2">
        <property type="protein sequence ID" value="ENSPANP00000028957.1"/>
        <property type="gene ID" value="ENSPANG00000030296.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101009365"/>
    <dbReference type="KEGG" id="panu:101009365"/>
    <dbReference type="CTD" id="2019"/>
    <dbReference type="GeneTree" id="ENSGT00940000160811"/>
    <dbReference type="OMA" id="CKKEQQQ"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030296">
        <property type="expression patterns" value="Expressed in gastrocnemius and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042756">
        <property type="term" value="P:drinking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990403">
        <property type="term" value="P:embryonic brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030917">
        <property type="term" value="P:midbrain-hindbrain boundary development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061743">
        <property type="term" value="P:motor learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000167">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019549">
        <property type="entry name" value="Homeobox-engrailed_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019737">
        <property type="entry name" value="Homeobox-engrailed_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10525">
        <property type="entry name" value="Engrail_1_C_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00033">
        <property type="entry name" value="ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="305"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="307"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU510713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="396" mass="40355" checksum="7C13BE6D5200852D" modified="2018-02-28" version="1">MEEQQPEPKSQRDSGLGAAAAAATPGGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTGAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAAAAAVAAAAAAAAAAKPSDSGGGGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M298</accession>
    <name>A0A2I3M298_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA-binding protein 45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Developmentally-regulated RNA-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RNA-binding motif protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RBM45</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003907713.1">
        <property type="nucleotide sequence ID" value="XM_003907664.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507243.1">
        <property type="nucleotide sequence ID" value="XM_031651383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M298"/>
    <dbReference type="SMR" id="A0A2I3M298"/>
    <dbReference type="Ensembl" id="ENSPANT00000038167.2">
        <property type="protein sequence ID" value="ENSPANP00000029835.2"/>
        <property type="gene ID" value="ENSPANG00000016088.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026132"/>
    <dbReference type="KEGG" id="panu:101026132"/>
    <dbReference type="CTD" id="129831"/>
    <dbReference type="GeneTree" id="ENSGT00680000100059"/>
    <dbReference type="OMA" id="MIPKTYT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016088">
        <property type="expression patterns" value="Expressed in ileum and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M298">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12366">
        <property type="entry name" value="RRM1_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12367">
        <property type="entry name" value="RRM2_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12368">
        <property type="entry name" value="RRM3_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12369">
        <property type="entry name" value="RRM4_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000292">
        <property type="entry name" value="RNA-binding motif protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000295">
        <property type="entry name" value="RNA-binding motif protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000290">
        <property type="entry name" value="RNA-binding protein 45 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034203">
        <property type="entry name" value="RBM45_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034206">
        <property type="entry name" value="RBM45_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034207">
        <property type="entry name" value="RBM45_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034208">
        <property type="entry name" value="RBM45_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="390"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029835.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="474" mass="53338" checksum="1F33D9680FA762BE" modified="2022-05-25" version="2">MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEELTRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQLMQFGGSSGSQLPQIQTDVVLPSCKKKAPPETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M5W9</accession>
    <name>A0A2I3M5W9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RPS6KA1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_003891440.1">
        <property type="nucleotide sequence ID" value="XM_003891391.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M5W9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031130"/>
    <dbReference type="Ensembl" id="ENSPANT00000035821.2">
        <property type="protein sequence ID" value="ENSPANP00000031130.1"/>
        <property type="gene ID" value="ENSPANG00000020222.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019087"/>
    <dbReference type="KEGG" id="panu:101019087"/>
    <dbReference type="CTD" id="6195"/>
    <dbReference type="GeneTree" id="ENSGT00940000159314"/>
    <dbReference type="OMA" id="ILEHSWV"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020222">
        <property type="expression patterns" value="Expressed in bone marrow and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M5W9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000491">
        <property type="term" value="P:positive regulation of hepatic stellate cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14175">
        <property type="entry name" value="STKc_RSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000041">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="71"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="19">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="427"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="77"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
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                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
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                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
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                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
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                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
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                <person name="Morales K.M."/>
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                <person name="Ngo D.N."/>
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                <person name="Quiroz J.Q."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Tang L.-Y.T."/>
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                <person name="Tisius J.T."/>
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                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
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                <person name="Vattathil S.V."/>
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                <person name="Zhu Y.Z."/>
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                <person name="Worley K.W."/>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_003896220.1">
        <property type="nucleotide sequence ID" value="XM_003896171.5"/>
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    <dbReference type="RefSeq" id="XP_017812331.1">
        <property type="nucleotide sequence ID" value="XM_017956842.1"/>
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        <property type="gene ID" value="ENSPANG00000021598.3"/>
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    <sequence length="353" mass="37430" checksum="4C2560A3D8E99D62" modified="2022-05-25" version="2">MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MEF4</accession>
    <name>A0A2I3MEF4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MEF4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000034084"/>
    <dbReference type="Ensembl" id="ENSPANT00000040115.2">
        <property type="protein sequence ID" value="ENSPANP00000034084.1"/>
        <property type="gene ID" value="ENSPANG00000005412.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159980"/>
    <dbReference type="OMA" id="XLPHVLQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005412">
        <property type="expression patterns" value="Expressed in amygdala and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MEF4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22168">
        <property type="entry name" value="F-box_FBXO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000002">
        <property type="entry name" value="F-box only protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000137">
        <property type="entry name" value="F-box only protein 44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF13">
        <property type="entry name" value="F-BOX ONLY PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="3">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28883" checksum="97F09223188D867E" modified="2018-02-28" version="1">MAVGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLSRDQRKEFPNDQHLPQVPGGGPQGRRVLGGADGYHTAGHRGQGLVRSQARLRVQVPAVRSAPVVRARASGDLPARPGNHPAEERCQVEGGLPHILQLPARRPLHLVSARRRGHSLLGRLVRPEGHQQQHHHRAPAALTPPEPPSAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MF28</accession>
    <name>A0A2I3MF28_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Coenzyme Q10A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COQ10A</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906649.1">
        <property type="nucleotide sequence ID" value="XM_003906600.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MF28"/>
    <dbReference type="SMR" id="A0A2I3MF28"/>
    <dbReference type="Ensembl" id="ENSPANT00000056781.2">
        <property type="protein sequence ID" value="ENSPANP00000034185.1"/>
        <property type="gene ID" value="ENSPANG00000004851.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010157"/>
    <dbReference type="CTD" id="93058"/>
    <dbReference type="GeneTree" id="ENSGT00940000160056"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004851">
        <property type="expression patterns" value="Expressed in gastrocnemius and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MF28">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000002">
        <property type="entry name" value="Coenzyme Q-binding protein COQ10 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF8">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10 HOMOLOG A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="9">
        <location>
            <begin position="61"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="215" mass="24500" checksum="0F271B7E54821450" modified="2018-02-28" version="1">MLLQVVREGKSSGFLTSCSLLLPRAAQILAAEAGLPWSRSFMGFAAPFTNKRKAYSERRIMGYSMQEMYEVVSNVQEYREFVPWCKKSLVVSSRKGHLKAQLEVGFPPVMERYTSAVSMVKPHMVKAVCTDGKLFNHLETIWRFSPGIPAYPRTCTVDFSISFEFRSLLHSQLATMFFDEVVKQNVAAFERRAATKFGPETAIPRELMFHEVHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MI37</accession>
    <name>A0A2I3MI37_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MI37"/>
    <dbReference type="Ensembl" id="ENSPANT00000049699.2">
        <property type="protein sequence ID" value="ENSPANP00000035371.2"/>
        <property type="gene ID" value="ENSPANG00000045860.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214413"/>
    <dbReference type="OMA" id="WCTDSKL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017450">
        <property type="expression patterns" value="Expressed in putamen and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MI37">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035371.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="113" mass="12698" checksum="CF858D51FA7BB1D9" modified="2022-05-25" version="2">MATEALHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQVGHTCCVMGERVLDFIAKGEEGCPFPKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MJL4</accession>
    <name>A0A2I3MJL4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer mitochondrial membrane 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MJL4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000035983"/>
    <dbReference type="Ensembl" id="ENSPANT00000057341.2">
        <property type="protein sequence ID" value="ENSPANP00000035983.2"/>
        <property type="gene ID" value="ENSPANG00000035693.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164197"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035693">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029179">
        <property type="entry name" value="TOMM5_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28436">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28436:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035983.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10508" checksum="F0611D3525C1A2DD" modified="2022-05-25" version="2">MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVSECLPGCDCETSGELTGGHPLTLHRGPTELNGSGEQGGSIYLKEIGQHMKTGHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MP68</accession>
    <name>A0A2I3MP68_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MP68"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037450"/>
    <dbReference type="Ensembl" id="ENSPANT00000039255.2">
        <property type="protein sequence ID" value="ENSPANP00000037450.2"/>
        <property type="gene ID" value="ENSPANG00000029806.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161436"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029806">
        <property type="expression patterns" value="Expressed in pituitary gland"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527:SF7">
        <property type="entry name" value="TUBULIN_FTSZ GTPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037450.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="119" mass="13067" checksum="4487E9B1FE62DF5D" modified="2022-05-25" version="2">MRKIVLTQAGQCGNQIGAKFWEVISDEHAIDCTGTYHGDSRLQLERIEVYYKEACGGKYVPRSVLVDLEPGTMDSVRLGPFGQIFRPDSFIFVTGCTVLQVRVGPEKTGPGGTTQKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MQQ5</accession>
    <name>A0A2I3MQQ5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitinase 3 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CHI3L2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009213453.2">
        <property type="nucleotide sequence ID" value="XM_009215189.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MQQ5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037961"/>
    <dbReference type="Ensembl" id="ENSPANT00000035265.2">
        <property type="protein sequence ID" value="ENSPANP00000037961.2"/>
        <property type="gene ID" value="ENSPANG00000004608.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998320"/>
    <dbReference type="KEGG" id="panu:100998320"/>
    <dbReference type="CTD" id="1117"/>
    <dbReference type="GeneTree" id="ENSGT00940000163351"/>
    <dbReference type="OMA" id="HETTKHH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004608">
        <property type="expression patterns" value="Expressed in zone of skin and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MQQ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000047">
        <property type="entry name" value="Chitinase-3-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF82">
        <property type="entry name" value="CHITINASE-3-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035151723" evidence="6">
        <location>
            <begin position="28"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="28"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037961.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="391" mass="43745" checksum="D95C297E1B381266" modified="2022-05-25" version="2">MMDHNISHIMGLRQGVVVLLLLQGGSAYKLVCYFTNWSQDRQEPGKFTPENVDPFLCSHLIYSFASIENNKVIIKDKNEVMLYQTINSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTSRLEFVNSVILFLRSHNFDGLDVSWIYPDQKENTHFTLLIHELAEAFQKDFTKSTKERLLLTAGVSAGRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPSSYYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETTVGAPASGPGAAGPITESSGFLAYYEICQFLKGAKITRLQDQQVPYAVKGNQWVGYDDVESMETKVRFLKNLNLGGAMIWSIDMDDFTGKSCNQGPYPLVQAVKRSLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MSB7</accession>
    <name>A0A2I3MSB7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane 4 L six family member 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TM4SF19</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the L6 tetraspanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MSB7"/>
    <dbReference type="Ensembl" id="ENSPANT00000042745.2">
        <property type="protein sequence ID" value="ENSPANP00000038668.1"/>
        <property type="gene ID" value="ENSPANG00000018681.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234590"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018681">
        <property type="expression patterns" value="Expressed in adrenal medulla and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MSB7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008661">
        <property type="entry name" value="L6_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14198">
        <property type="entry name" value="TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14198:SF22">
        <property type="entry name" value="TRANSMEMBRANE 4 L6 FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05805">
        <property type="entry name" value="L6_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="19695" checksum="5641B086D74400A6" modified="2018-02-28" version="1">MLSSPCTPARSRTCSRILGLSLGTAALFAAGANMALLCPNWDVTYLLRGLIGKHAMLGTGLWGGGLMVLTALLSSGLALLGALICFVTSGAALKDGPFCMFDTSSFNQTQAWKYGYPFKDLHSRNYLYDRLLWNSVCLEPSTAVVWHVSLFSALLCISLLQLLLVVAHVINSLLGLFCSLCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N3Y8</accession>
    <name>A0A2I3N3Y8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myelin basic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MBP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Myelin membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin basic protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N3Y8"/>
    <dbReference type="Ensembl" id="ENSPANT00000033910.2">
        <property type="protein sequence ID" value="ENSPANP00000042744.1"/>
        <property type="gene ID" value="ENSPANG00000023229.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014772"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023229">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N3Y8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043218">
        <property type="term" value="C:compact myelin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033269">
        <property type="term" value="C:internode region of axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000548">
        <property type="entry name" value="Myelin_BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11429">
        <property type="entry name" value="MYELIN BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11429:SF0">
        <property type="entry name" value="MYELIN BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01669">
        <property type="entry name" value="Myelin_MBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00212">
        <property type="entry name" value="MYELINMBP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00569">
        <property type="entry name" value="MYELIN_MBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="253" mass="27657" checksum="83DD6C73D20B7DCD" modified="2018-02-28" version="1">MGNHAGKRELNTEKASTNGETNRGEPEKKTNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGVPKRGSGKDSHHAARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N3Z2</accession>
    <name>A0A2I3N3Z2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger protein 692</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AICAR responsive element binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF692</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893669.2">
        <property type="nucleotide sequence ID" value="XM_003893620.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788083.2">
        <property type="nucleotide sequence ID" value="XM_021932391.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031516360.1">
        <property type="nucleotide sequence ID" value="XM_031660500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N3Z2"/>
    <dbReference type="Ensembl" id="ENSPANT00000046971.2">
        <property type="protein sequence ID" value="ENSPANP00000042732.2"/>
        <property type="gene ID" value="ENSPANG00000020298.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022876"/>
    <dbReference type="KEGG" id="panu:101022876"/>
    <dbReference type="CTD" id="55657"/>
    <dbReference type="GeneTree" id="ENSGT00940000161175"/>
    <dbReference type="OMA" id="MVWECLA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020298">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N3Z2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000183">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000511">
        <property type="entry name" value="zinc finger protein 692 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000577">
        <property type="entry name" value="zinc finger protein 692 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000598">
        <property type="entry name" value="zinc finger protein 692 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="474"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042732.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="519" mass="56988" checksum="734178098C57D981" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NBZ9</accession>
    <name>A0A2I3NBZ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARFGEF family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARFGEF3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
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                <person name="Muzny D.M."/>
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                <person name="Akbar H.A."/>
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                <person name="Chau D.C."/>
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                <person name="Javaid M.J."/>
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                <person name="Nguyen L.N."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NG57"/>
    <dbReference type="Ensembl" id="ENSPANT00000039192.2">
        <property type="protein sequence ID" value="ENSPANP00000046831.2"/>
        <property type="gene ID" value="ENSPANG00000032502.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00410000028330"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032502">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 44 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046831.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="195" mass="20672" checksum="C6837E7650599044" modified="2022-05-25" version="2">MAADAGMAPRPLRRTLLGSGRRPVGPLARRRPPGGRDAGRAAERRRTAQAGQQAGSRAFRDCHTRRPRAPYPVSAAWALIGRDLDFRVLIGVAKCSSLPPPALACNARSPPASKEGAVCGIARPKTPRVNSSQDQIQVASGNTRSGSRHQHPASGRRLPASCGQEVPLFSQQAVGGLEPREQSEAYTPASFLPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NIK2</accession>
    <name>A0A2I3NIK2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Somatotropin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the somatotropin/prolactin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3NIK2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000047701"/>
    <dbReference type="Ensembl" id="ENSPANT00000046309.2">
        <property type="protein sequence ID" value="ENSPANP00000047701.2"/>
        <property type="gene ID" value="ENSPANG00000031798.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182818"/>
    <dbReference type="OMA" id="HIVQCHS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031798">
        <property type="expression patterns" value="Expressed in pituitary gland and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005131">
        <property type="term" value="F:growth hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060396">
        <property type="term" value="P:growth hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045927">
        <property type="term" value="P:positive regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001400">
        <property type="entry name" value="Somatotropin/Prolactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417:SF70">
        <property type="entry name" value="CHORIONIC SOMATOMAMMOTROPIN HORMONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417">
        <property type="entry name" value="SOMATOTROPIN,PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00103">
        <property type="entry name" value="Hormone_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00836">
        <property type="entry name" value="SOMATOTROPIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286348" description="Somatotropin" evidence="6">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047701.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18625" checksum="0418B637E66CC48B" modified="2022-05-25" version="2">MAAGSRTSQILAFALLCLPWLQQAGAVQSVPLSRFFDNAMLHAHRLHQLAFDTYQKFEEAYIPKEQKYSFLQNPQTSLCSSESIPTPSNMEEKQQKSNLELLRISLLLIQSWLEPVQFLRSVFANRLVCGTADSDYDLLKSLEEGIQTLMGVTVVPGVPNPGKPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MVM3</accession>
    <name>A0A8I5MVM3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZNF589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MVM3"/>
    <dbReference type="Ensembl" id="ENSPANT00000070467.1">
        <property type="protein sequence ID" value="ENSPANP00000048844.1"/>
        <property type="gene ID" value="ENSPANG00000034725.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164260"/>
    <dbReference type="OMA" id="KPYVCRN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000155">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001286">
        <property type="entry name" value="Zinc finger protein 485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001895">
        <property type="entry name" value="Zinc finger protein 559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048414">
        <property type="entry name" value="PDRM9-like_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF395">
        <property type="entry name" value="ZINC FINGER PROTEIN 875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21225">
        <property type="entry name" value="zf-C2H2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="12">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="365" mass="41068" checksum="02A61B05907DF14F" modified="2022-05-25" version="1">MWAPREQLLGSATEALPAKDSVWPWEGKPRYLGPVTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPGDQPQPQCPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGTLVGFSSLFQRPPISSQGGNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVRFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSQCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFRENSELIKHQRIHTGDKPYVCRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MWP2</accession>
    <name>A0A8I5MWP2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase TBK1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">T2K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">TANK-binding kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TBK1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003906770.1">
        <property type="nucleotide sequence ID" value="XM_003906721.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009179393.1">
        <property type="nucleotide sequence ID" value="XM_009181129.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MWP2"/>
    <dbReference type="SMR" id="A0A8I5MWP2"/>
    <dbReference type="Ensembl" id="ENSPANT00000073906.1">
        <property type="protein sequence ID" value="ENSPANP00000048758.1"/>
        <property type="gene ID" value="ENSPANG00000001025.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999858"/>
    <dbReference type="KEGG" id="panu:100999858"/>
    <dbReference type="CTD" id="29110"/>
    <dbReference type="GeneTree" id="ENSGT00950000182937"/>
    <dbReference type="OMA" id="WSADMPV"/>
    <dbReference type="OrthoDB" id="10013850at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="term" value="F:protein serine kinase activity"/>
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        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
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        <property type="term" value="P:protein import into nucleus"/>
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        <property type="term" value="P:T follicular helper cell differentiation"/>
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        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
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    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="9"/>
            <end position="310"/>
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            <position position="38"/>
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        <ligand>
            <name>ATP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00071338"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00077824"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081637"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048758.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="729" mass="83589" checksum="14E384DF6270853F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZX9</accession>
    <name>A0A8I5MZX9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Keratin associated protein 20-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KRTAP20-2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with hair keratins.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZX9"/>
    <dbReference type="Ensembl" id="ENSPANT00000080085.1">
        <property type="protein sequence ID" value="ENSPANP00000052182.1"/>
        <property type="gene ID" value="ENSPANG00000046975.1"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="KRTAP_matrix"/>
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        <property type="entry name" value="KRTAP_type8/19/20/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39653">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 20-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39653:SF6">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 20-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11759">
        <property type="entry name" value="KRTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0416">Keratin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="67" mass="7046" checksum="D727415916B1E760" modified="2022-05-25" version="1">MCYYVSYYGSLGYGYGGLGCSYDCGCGYGHGYGGLGCGYGCGCGYGGYGYGCCRPSCYGRYRSCGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0V7</accession>
    <name>A0A8I5N0V7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0V7"/>
    <dbReference type="Ensembl" id="ENSPANT00000061104.1">
        <property type="protein sequence ID" value="ENSPANP00000051556.1"/>
        <property type="gene ID" value="ENSPANG00000043866.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="CEASTAK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="900" mass="104209" checksum="6E8AE076BCB588B7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC81</accession>
    <name>A0A8I5NC81_PAPAN</name>
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        <recommendedName>
            <fullName evidence="3">Protein angel homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANGEL1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009210274.2">
        <property type="nucleotide sequence ID" value="XM_009212010.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC81"/>
    <dbReference type="Ensembl" id="ENSPANT00000075463.1">
        <property type="protein sequence ID" value="ENSPANP00000054491.1"/>
        <property type="gene ID" value="ENSPANG00000023844.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101001549"/>
    <dbReference type="CTD" id="23357"/>
    <dbReference type="GeneTree" id="ENSGT00940000159057"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000025">
        <property type="entry name" value="Angel homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
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                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine</text>
            <dbReference type="Rhea" id="RHEA:60520"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:143812"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 24">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine</text>
            <dbReference type="Rhea" id="RHEA:62704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:145925"/>
            <dbReference type="ChEBI" id="CHEBI:145926"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>leukotriene D4 + H2O = leukotriene E4 + glycine</text>
            <dbReference type="Rhea" id="RHEA:48616"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57462"/>
            <dbReference type="ChEBI" id="CHEBI:63166"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 24">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Apical cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Membrane</location>
            <topology evidence="24">Lipid-anchor</topology>
            <topology evidence="24">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="24"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5ND42"/>
    <dbReference type="Ensembl" id="ENSPANT00000066655.1">
        <property type="protein sequence ID" value="ENSPANP00000060032.1"/>
        <property type="gene ID" value="ENSPANG00000008151.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159615"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901749">
        <property type="term" value="P:leukotriene D4 catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000030">
        <property type="entry name" value="Dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF38">
        <property type="entry name" value="DIPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 24" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="18 24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 24" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9 24" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <keyword evidence="13 24" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339844" description="Dipeptidase" evidence="24">
        <location>
            <begin position="17"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="360"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="726" mass="79763" checksum="6F959DD71FFE9B00" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHZ9</accession>
    <name>A0A8I5NHZ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHZ9"/>
    <dbReference type="Ensembl" id="ENSPANT00000062078.1">
        <property type="protein sequence ID" value="ENSPANP00000058997.1"/>
        <property type="gene ID" value="ENSPANG00000048571.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166898"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF161">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="195" mass="22366" checksum="648A8D4D0AD720EA" modified="2022-05-25" version="1">MSISPALRSLYASGRTEERHLRTHLPSPLHSTTFKKVSLSSLFSLSFFRRSLTPSPRLEYSGEILAHGSLRLLGSSDFSCLGLLGSWDYRHGPPCPANFYFILFYFILFYFILFYFILFYFLRWSLALSPRLECNGTILVHRNLPLPGSSDSPASASRVAEITGAYHHTQLIFCIFSRDRVSLCWPDWSRTPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NIR9</accession>
    <name>A0A8I5NIR9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIR9"/>
    <dbReference type="Ensembl" id="ENSPANT00000066065.1">
        <property type="protein sequence ID" value="ENSPANP00000052328.1"/>
        <property type="gene ID" value="ENSPANG00000050459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="95" mass="10541" checksum="35EC225407BE7B22" modified="2022-05-25" version="1">MVSAHCNLHLPGSSNSPFLSHLSGWDHRCQPPRLNNFFFLRRSLALSPKLECSGRISAHCKLRRPSLRHSPASASRVAGTTGACHLARLVFFCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJC9</accession>
    <name>A0A8I5NJC9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJC9"/>
    <dbReference type="Ensembl" id="ENSPANT00000077252.1">
        <property type="protein sequence ID" value="ENSPANP00000048110.1"/>
        <property type="gene ID" value="ENSPANG00000038186.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164691"/>
    <dbReference type="OMA" id="HESTHIK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001004">
        <property type="entry name" value="Zinc finger protein 426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000051">
        <property type="entry name" value="zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002280">
        <property type="entry name" value="Zinc finger protein 669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="260" mass="29946" checksum="B9EFB0906C5D5706" modified="2022-05-25" version="1">MRTFLLDENNVNAVFVEKSLYVIPSLIGLNRHILVHSGYKPYGEKPYKWEQCEKFFISVPGVRRHVIMHSGNPAYKCTLCRKAFHFLNSVERHQRTHTGEKPYQCKQCGKAFTVSSSCLIHERTHTGEKPYECKECGKTFRFSCSFKTRERTHTGERPYKCTKCDEAFSCSTSLHDHGSVHTGERPYECKQCDQVFSRLSSLHLHERIHTGEKPYEWAGSGQQWPEPLDSLLKAASAHLPEIPVTVTCRPIQEQNVDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJK2</accession>
    <name>A0A8I5NJK2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer dense fiber of sperm tails 3B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJK2"/>
    <dbReference type="Ensembl" id="ENSPANT00000062532.1">
        <property type="protein sequence ID" value="ENSPANP00000059897.1"/>
        <property type="gene ID" value="ENSPANG00000044548.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161995"/>
    <dbReference type="OMA" id="QRASTHH"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF19">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29901" checksum="2CC5506DF1D77492" modified="2022-05-25" version="1">MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNTGYVLHDPSRPRAPAFTFGARLPTQQTTCGPGPGHLVPARMTVRGPDGAPAYSIYGRPRRSAPFLTPGPGPHPVPDPHTLDPPRRQVLPGASGERDVPQCASAHHCSPKLGCPGGAAEPRSRGLYCALALGSTCHRQSLRPNLLHLRPQSGGQFLRGPQQDPRPMRLPRREPGGLQVPGPPVHHAGADFAPPRQHSEARARGLQRGPATEAPRLELRDPTLGLPGPAGDPRGHLTWQAGAAPHLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJY9</accession>
    <name>A0A8I5NJY9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJY9"/>
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        <property type="protein sequence ID" value="ENSPANP00000048483.1"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="entry name" value="Histone H3.3"/>
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    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
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    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
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    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
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    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0164">Citrullination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="16">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="137" mass="15521" checksum="EE9F8D5FDEA50A0E" modified="2022-05-25" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGNIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKS3</accession>
    <name>A0A8I5NKS3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED21</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906188.1">
        <property type="nucleotide sequence ID" value="XM_003906139.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKS3"/>
    <dbReference type="SMR" id="A0A8I5NKS3"/>
    <dbReference type="Ensembl" id="ENSPANT00000076750.1">
        <property type="protein sequence ID" value="ENSPANP00000053445.1"/>
        <property type="gene ID" value="ENSPANG00000013655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025320"/>
    <dbReference type="KEGG" id="panu:101025320"/>
    <dbReference type="CTD" id="9412"/>
    <dbReference type="GeneTree" id="ENSGT00390000014557"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0010">Activator</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="144" mass="15523" checksum="CA30B4DF0B7C63AC" modified="2022-05-25" version="1">MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGSHSQSLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NL55</accession>
    <name>A0A8I5NL55_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-eEF1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NL55"/>
    <dbReference type="Ensembl" id="ENSPANT00000066687.1">
        <property type="protein sequence ID" value="ENSPANP00000053919.1"/>
        <property type="gene ID" value="ENSPANG00000050246.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154037"/>
    <dbReference type="OMA" id="HICIESF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44830">
        <property type="entry name" value="ELONGATION FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44830:SF1">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP-eEF1A C-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="162" mass="16616" checksum="D2C637093378BE27" modified="2022-05-25" version="1">MHHEASSEALPGDNVGFNAKNISVKNVCHGNVAGDRKNDPSVGATSFTAQVIILHYPGQISAGYAAILDCQTVHIACNFAELRGKIDHHSCKKLEDGPTFLKLGEAVVTEIVSGKPSIIDTTEDGGSPPGGTSESSSSSSLPGSSATHQSPSSAVPCPGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NPR6</accession>
    <name>A0A8I5NPR6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031520174.1">
        <property type="nucleotide sequence ID" value="XM_031664314.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000060886.1">
        <property type="protein sequence ID" value="ENSPANP00000052597.1"/>
        <property type="gene ID" value="ENSPANG00000019214.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010765"/>
    <dbReference type="KEGG" id="panu:101010765"/>
    <dbReference type="CTD" id="54897"/>
    <dbReference type="GeneTree" id="ENSGT00940000167357"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040373">
        <property type="entry name" value="CASZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451">
        <property type="entry name" value="TRANSCRIPTION FACTOR CASTOR PROTEIN MING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN CASTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1481"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1644"/>
        </location>
    </feature>
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            <begin position="161"/>
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    </feature>
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            <begin position="411"/>
            <end position="420"/>
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    </feature>
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            <begin position="421"/>
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    </feature>
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            <begin position="431"/>
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    </feature>
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            <begin position="711"/>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="1091"/>
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    </feature>
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        <location>
            <begin position="1105"/>
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    </feature>
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        <location>
            <begin position="1697"/>
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        <location>
            <begin position="1748"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052597.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="1782" mass="192943" checksum="7C1C895C2D0C964E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQF0</accession>
    <name>A0A8I5NQF0_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
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        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="Ensembl" id="ENSPANP00000056013.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="108" mass="11945" checksum="FE6B437D70CC8D66" modified="2022-05-25" version="1">TVFLGSQGRLLGKRKEITCILREETELCKEEGQDRGTLFFFFLRQSLALLPRLECSGVISAHCNLYLLGSSDSRASVSQIAGTTGVHHHAWLIFCIFSRDGGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQN1</accession>
    <name>A0A8I5NQN1_PAPAN</name>
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        <submittedName>
            <fullName evidence="6">Nucleosome assembly protein 1 like 2</fullName>
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        <name evidence="6" type="primary">NAP1L2</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <text evidence="2 4">Belongs to the nucleosome assembly protein (NAP) family.</text>
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        <property type="gene ID" value="ENSPANG00000001287.3"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
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    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
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    <proteinExistence type="inferred from homology"/>
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            <begin position="1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="460" mass="52540" checksum="979AF078E0E7F229" modified="2022-05-25" version="1">MAESANHKELSESSQQEAGNQIMVEGPGEHPERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGEKGEDTDKDSDPDRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDYDDEEMCDEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEDEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQP2</accession>
    <name>A0A8I5NQP2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
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                <person name="Akbar H.A."/>
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                <person name="Newsham I.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="protein sequence ID" value="ENSPANP00000056990.1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:inhibitory MHC class I receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leukocyte immunoglobulin-like receptor subfamily B member 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
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    <dbReference type="PANTHER" id="PTHR11738:SF179">
        <property type="entry name" value="LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="280" mass="29829" checksum="B24720BB29CD2B93" modified="2022-05-25" version="1">EDTQGSQPQALPSGRGSALRGVSLSQPSPGDDVGGGSPLNTVPPSLLGAYSKPTLSALPSPVVASGGNVTLRCGSQRGYQHFVLIEEGEHRLPQTLDSQQLHSGWYQALFPVGPVTTSHRWTFRCYGYYSNTSQVWSHRSDPLEILASGVSRKPSLLMLQGPVVAPGENLTLQCRSDVDYDRFTLHKAGQRTFLQRPGQQSQAGLSQANFTLGPVRGSHGGQYRCYGAHNLSSEWSAPSDPLDILIAGEEPSGFNQGSRLCTGPAGGAQVVMAGMEGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NWB7</accession>
    <name>A0A8I5NWB7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 14 open reading frame 180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C14orf180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NWB7"/>
    <dbReference type="Ensembl" id="ENSPANT00000063720.1">
        <property type="protein sequence ID" value="ENSPANP00000058671.1"/>
        <property type="gene ID" value="ENSPANG00000037690.1"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:100998520"/>
    <dbReference type="GeneTree" id="ENSGT00390000001214"/>
    <dbReference type="OMA" id="LACWHCL"/>
    <dbReference type="OrthoDB" id="9535799at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028114">
        <property type="entry name" value="DUF4658"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36868">
        <property type="entry name" value="NUTRITIONALLY-REGULATED ADIPOSE AND CARDIAC ENRICHED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36868:SF1">
        <property type="entry name" value="NUTRITIONALLY-REGULATED ADIPOSE AND CARDIAC ENRICHED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15555">
        <property type="entry name" value="DUF4658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="157" mass="17733" checksum="F6FD0378572C25CE" modified="2022-05-25" version="1">MRTAALSPDSRPETRHQTRKNEEAAWGPRACRAEREDKKCPPSILKRSRPEHHRPGAEPQRTSRHVRFQEPPAVTVHYIADRNTTATIRVPGRPRPHSGSLLLRLCVCVLLLLALGLYCGRAKPVATALEDLRARLFSLVLHLQHAALTCWHGLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYF9</accession>
    <name>A0A8I5NYF9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Interferon-induced transmembrane protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NYF9"/>
    <dbReference type="Ensembl" id="ENSPANT00000080405.1">
        <property type="protein sequence ID" value="ENSPANP00000055998.1"/>
        <property type="gene ID" value="ENSPANG00000042949.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182857"/>
    <dbReference type="OMA" id="HKECHIQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046597">
        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035455">
        <property type="term" value="P:response to interferon-alpha"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035456">
        <property type="term" value="P:response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051517">
        <property type="entry name" value="IFITM_antiviral_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13999">
        <property type="entry name" value="INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13999:SF4">
        <property type="entry name" value="INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14691" checksum="9B7EA322E4ECC519" modified="2022-05-25" version="1">MNHTVQTFFSPVNSGQPPNYEILKEEHEVAMLGAPHNPAPPTSTVIHIRSETSVPDHVVWSLFNTLFMNPCCLGFIAFAYSVKSRDRKMVGDLTGAQAYASTAKCLNIWALILGILMTILLIVVPVLIFQAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZL7</accession>
    <name>A0A8I5QZL7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Multivesicular body subunit 12B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ESCRT-I complex subunit MVB12B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein FAM125B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MVB12B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MVB12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZL7"/>
    <dbReference type="Ensembl" id="ENSPANT00000063789.1">
        <property type="protein sequence ID" value="ENSPANP00000049558.1"/>
        <property type="gene ID" value="ENSPANG00000049397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155945"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046755">
        <property type="term" value="P:viral budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019075">
        <property type="term" value="P:virus maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.100.10.50:FF:000002">
        <property type="entry name" value="Multivesicular body subunit 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018798">
        <property type="entry name" value="MVB12A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040297">
        <property type="entry name" value="MVB12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31547">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31547:SF1">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10240">
        <property type="entry name" value="DUF2464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MABP" evidence="13">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="290" mass="32168" checksum="F8B4FEE08F194D8E" modified="2022-05-25" version="1">MPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHLGNVLVDMKLIDIKDTLPVGFIPIQETVDTQEVAFRKKRLCIKFIPRDSTEAAICDIRIMGRTKQAPPQYTFIGELNSMGIWYRMGRVPRNHDSSQPTTPSQSSAASTPAPNLPRHISLTLPATFRGRNSTRTDYEYQHSNLYAISGTWSHCAGQLRSLRPGHHLLPHVLCLLMGSVCLTSLFFPARGLFPAGTRPSLSFVSPRNLEKGQILSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZX0</accession>
    <name>A0A8I5QZX0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">37 kDa laminin receptor precursor</fullName>
            <shortName evidence="13">37LRP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">37/67 kDa laminin receptor</fullName>
            <shortName evidence="13">LRP/LR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">67 kDa laminin receptor</fullName>
            <shortName evidence="13">67LR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminin receptor 1</fullName>
            <shortName evidence="13">LamR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminin-binding protein precursor p40</fullName>
            <shortName evidence="13">LBP/p40</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RPSA</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <text evidence="13">67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13">Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13">Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZX0"/>
    <dbReference type="Ensembl" id="ENSPANT00000083029.1">
        <property type="protein sequence ID" value="ENSPANP00000050422.1"/>
        <property type="gene ID" value="ENSPANG00000016823.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183099"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005055">
        <property type="term" value="F:laminin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03016">
        <property type="entry name" value="Ribosomal_S2_laminin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027504">
        <property type="entry name" value="Ribosomal_uS2_vert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 13 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 13 14" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="15">
        <location>
            <begin position="191"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Laminin-binding" evidence="13">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Laminin-binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by ST3; site 1" evidence="13">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by ST3; site 2" evidence="13">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylserine" evidence="13">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="319" mass="35796" checksum="B251D65E8832A979" modified="2022-05-25" version="1">MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTDWSAQPATEDWSAAPTAQATEWIFLEMSWGQGESYNCTYIYPNSTSCCTLTERQWSKKHSPLSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R0K1</accession>
    <name>A0A8I5R0K1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRWD/PHIP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R0K1"/>
    <dbReference type="Ensembl" id="ENSPANT00000067343.1">
        <property type="protein sequence ID" value="ENSPANP00000053089.1"/>
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    <dbReference type="OMA" id="CHRAAQV"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Bromo_WD_repeat"/>
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        <property type="entry name" value="BRWD/PHIP_N"/>
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    <dbReference type="PANTHER" id="PTHR16266:SF26">
        <property type="entry name" value="BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25437">
        <property type="entry name" value="BRWD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRWD/PHIP N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="151" mass="16885" checksum="2560427024E971E9" modified="2022-05-25" version="1">MPARSGLGAASARPTRLANTLAPAFRHKPAIAEASSTRGRVRLMELELYFLIARYLSAGLCWRAAQALMHELEQHQLLPKRLDWEGNAHNTSYEELVSSNKHVAPDHLLYCRRTGAMLDKEIPPSISRVTSSLTAARQSLLRTAKGRERTR</sequence>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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    <dbReference type="Ensembl" id="ENSPANT00000076014.1">
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="141" mass="15181" checksum="47170B3B433A7CD3" modified="2022-05-25" version="1">MEEQAQSLTDKTRVAFQQGKIFPTSISVAPPAGTMIPPPSSLLGPPHPGMMPAAHMGPPPRMMPVGPAPGMRLPMGSHMPMMPGPPMMRPLACPMMVPTWPRMTRADRKDRGEASPYQFYITCSTSPGDYNAVTLGVFFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R171</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R171"/>
    <dbReference type="Ensembl" id="ENSPANT00000069948.1">
        <property type="protein sequence ID" value="ENSPANP00000055201.1"/>
        <property type="gene ID" value="ENSPANG00000045988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000212061"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="45" mass="4378" checksum="8ED826F1C9DEB5DB" modified="2022-05-25" version="1">MEPGGDHRSRSSGGGSGPVASARGRRLPPAGSSGSAEPEEDEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R233</accession>
    <name>A0A8I5R233_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R233"/>
    <dbReference type="Ensembl" id="ENSPANT00000074635.1">
        <property type="protein sequence ID" value="ENSPANP00000058009.1"/>
        <property type="gene ID" value="ENSPANG00000037090.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163260"/>
    <dbReference type="OMA" id="FATICGN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001594">
        <property type="term" value="F:trace-amine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009132">
        <property type="entry name" value="TAAR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF82">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01830">
        <property type="entry name" value="TRACEAMINER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="48"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="20605" checksum="99DFCF84850BCDAE" modified="2022-05-25" version="1">MDLIYIPEDLSSCPKFVNKSCPPTNRSFHVRVIMYSVMTGAMIITIFGNLVIIVSISHFKQLHSPTNFLILSMATTDFLLGSVIMPYSMVRSVESCWYFGDGFCKFHTSFDMMLSLTSIFHLCSIAIDRFYAVCYPLYYTTRMTSSTIKRLLAFCWSVPALFSFGLVLSEANVSACSSHQPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2X9</accession>
    <name>A0A8I5R2X9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R2X9"/>
    <dbReference type="Ensembl" id="ENSPANT00000074880.1">
        <property type="protein sequence ID" value="ENSPANP00000061195.1"/>
        <property type="gene ID" value="ENSPANG00000039699.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="428" mass="44327" checksum="D0880EFEC491DDC4" modified="2022-05-25" version="1">MAGPSGSLMGCQPPPPPGCHLGTQPLPPSGGFLGPQQTSPLECPLGTQPPPTLESPLKTQPPPPLNCSLGPLPAPAADSPPGPHPPVAVSPPGPHPPSCMPSQSLQDLIHLQLSVLQDLIHLLQLSVLQDLIHLQLSVLWDLIHLLQLLVLWDLIHLLQLSVLQDLIHLLQLSVLWDLIHRQLSVLPGPHPPPAAVGPLGPHLPPAAGGPLGPYPPSAPAGPLGPHPPPAAVGPPGSHPHPAAVGPLGPHPPPAAIGLLGPNSPANCVCPPGPHLPPAALGPPGPYPSSACFCPPGPHPSFIAAFPLGHHSPFCSVRPLGPQTTSSLSNLWILSHAFYLGGIWPLNNHLHMNLLRYFNDLHSWPLGLQPPPPPGSPLAHLPPSPLGWPLLSEPTPPGPQPAPLPIVACKTSTTTSTCTISCVYLNSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R7Q6</accession>
    <name>A0A8I5R7Q6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R7Q6"/>
    <dbReference type="Ensembl" id="ENSPANT00000076880.1">
        <property type="protein sequence ID" value="ENSPANP00000054440.1"/>
        <property type="gene ID" value="ENSPANG00000045484.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="101" mass="10795" checksum="874DB6C8D0B118C7" modified="2022-05-25" version="1">VIVLDFGCSNRLEYNGAIWAHCNLYLLDSSNSSATVYQVAGITGAPHHNQLIFVYLVETGFHHIGPLRASSDLPASASQSVGITGVSHPTLQKSVFVKSVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2025-04-09" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A9RA88</accession>
    <name>INSI2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin-induced gene 2 protein</fullName>
            <shortName evidence="2">INSIG-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">INSIG2</name>
    </gene>
    <organism>
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2007-12" db="EMBL/GenBank/DDBJ databases">
            <title>NISC comparative sequencing initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The KxHxx motif mediates association with the coatomer complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000513">
        <property type="protein sequence ID" value="ABX89270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162382.1">
        <property type="nucleotide sequence ID" value="NM_001168911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183295.1">
        <property type="nucleotide sequence ID" value="XM_009185031.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183297.1">
        <property type="nucleotide sequence ID" value="XM_009185033.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183298.1">
        <property type="nucleotide sequence ID" value="XM_009185034.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779082.1">
        <property type="nucleotide sequence ID" value="XM_021923390.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9RA88"/>
    <dbReference type="SMR" id="A9RA88"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004968"/>
    <dbReference type="GeneID" id="100137376"/>
    <dbReference type="KEGG" id="panu:100137376"/>
    <dbReference type="CTD" id="51141"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092922_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024543">
        <property type="expression patterns" value="Expressed in liver and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032937">
        <property type="term" value="C:SREBP-SCAP-Insig complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036316">
        <property type="term" value="P:SREBP-SCAP complex retention in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF10">
        <property type="entry name" value="INSULIN-INDUCED GENE 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0153">Cholesterol metabolism</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0558">Oxidation</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0882">Thioester bond</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000339170" description="Insulin-induced gene 2 protein">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="KxHxx" evidence="2">
        <location>
            <begin position="219"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="site" description="Required for the recognition of 25-hydroxycholesterol" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="modified residue" description="Cysteine sulfenic acid (-SOH); alternate" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A1T557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9Y5U4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="225" mass="24792" checksum="13E023351B2AEA8C" modified="2008-02-05" version="1">MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATLVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKW4</accession>
    <name>A0A096MKW4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ALDH3B1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909501.1">
        <property type="nucleotide sequence ID" value="XM_003909452.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183753.1">
        <property type="nucleotide sequence ID" value="XM_009185489.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009183754.1">
        <property type="nucleotide sequence ID" value="XM_009185490.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017803684.1">
        <property type="nucleotide sequence ID" value="XM_017948195.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKW4"/>
    <dbReference type="Ensembl" id="ENSPANT00000009617.3">
        <property type="protein sequence ID" value="ENSPANP00000000151.1"/>
        <property type="gene ID" value="ENSPANG00000010862.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004156"/>
    <dbReference type="KEGG" id="panu:101004156"/>
    <dbReference type="CTD" id="221"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162915"/>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OMA" id="MKDQKVP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010862">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 49 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MKW4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004028">
        <property type="term" value="F:3-chloroallyl aldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07132">
        <property type="entry name" value="ALDH_F3AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF2">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="468" mass="52057" checksum="2E357D94210111EB" modified="2014-11-26" version="1">MDPFEDTLRRLREAFHTGRTRSAEFRAAQLRGLGRFLHENKQLLHDALAQDLHKSAFESELSEVAISQGEITLALRNLRAWMKDEHVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKSMEKVLAEVLPRYLDESCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGHVAIGGQSDESDRYIAPTVLVDVQETEPVMQEEIFGPILPIVNVRSVDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGQYHGKFSFDTFSHHRACLLRRPGMEKLNALRYPPHSPRRLRVLLVAMEARGCSCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLF3</accession>
    <name>A0A096MLF3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Interphotoreceptor matrix proteoglycan 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Sialoprotein associated with cones and rods proteoglycan</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">IMPG2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Photoreceptor inner segment membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Photoreceptor outer segment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Interphotoreceptor matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021789671.2">
        <property type="nucleotide sequence ID" value="XM_021933979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MLF3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000369"/>
    <dbReference type="Ensembl" id="ENSPANT00000000580.3">
        <property type="protein sequence ID" value="ENSPANP00000000369.3"/>
        <property type="gene ID" value="ENSPANG00000017183.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101002416"/>
    <dbReference type="KEGG" id="panu:101002416"/>
    <dbReference type="CTD" id="50939"/>
    <dbReference type="eggNOG" id="ENOG502QT6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063503"/>
    <dbReference type="HOGENOM" id="CLU_005111_0_0_1"/>
    <dbReference type="OMA" id="ESSIWPW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017183">
        <property type="expression patterns" value="Expressed in pineal body and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MLF3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033165">
        <property type="term" value="C:interphotoreceptor matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060042">
        <property type="term" value="P:retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.960:FF:000002">
        <property type="entry name" value="Interphotoreceptor matrix proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039861">
        <property type="entry name" value="IMPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12199">
        <property type="entry name" value="INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12199:SF4">
        <property type="entry name" value="INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1101"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="22">
        <location>
            <begin position="238"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="22">
        <location>
            <begin position="898"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1011"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1020"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000369.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1242" mass="138663" checksum="AE311CB3CC2369C6" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNK6</accession>
    <name>A0A096MNK6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CHST7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031516669.1">
        <property type="nucleotide sequence ID" value="XM_031660809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNK6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001238"/>
    <dbReference type="Ensembl" id="ENSPANT00000017005.3">
        <property type="protein sequence ID" value="ENSPANP00000001238.3"/>
        <property type="gene ID" value="ENSPANG00000008543.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012848"/>
    <dbReference type="KEGG" id="panu:101012848"/>
    <dbReference type="CTD" id="56548"/>
    <dbReference type="eggNOG" id="ENOG502QRPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162231"/>
    <dbReference type="HOGENOM" id="CLU_028381_1_0_1"/>
    <dbReference type="OMA" id="WKMNKVI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008543">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008459">
        <property type="term" value="F:chondroitin 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF5">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035198419" description="Sulfotransferase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="14">
        <location>
            <begin position="270"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001238.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="486" mass="54136" checksum="7A232398296254FC" modified="2022-05-25" version="3">MKGRRRRRREYCKFALLLVLYTLVLLLVPSVLDGGRDGDKGAGHCPGLQRSLGVWSLEAAAAGEREQGAEARAAAEGGASQSPRSPSNLSSAVGEAVSREKQHIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFRCDFSVLRLYAPPGDPDARAPDTANLTTAALFRWRTNKVICSPPLCPGAPRARAEVGLVEDTACERSCPPVAIRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDRFHRVLLAHGVGARPGGQSRALPAAPRADFFLTGALEVICEAWLRDLLFARGAPAWLRRRYLRLRYEDLVRQPRAQLRRLLRFSGLRALAALDAFALNMTRGAAYGADRPFHLSARDAREAVHAWRERLSREQVRQVEAACAPAMRLLAYPRSGEEGDVEPPRDGETPLEMDADSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPM1</accession>
    <name>A0A096MPM1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TMEM121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902403.1">
        <property type="nucleotide sequence ID" value="XM_003902354.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021797362.1">
        <property type="nucleotide sequence ID" value="XM_021941670.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031524880.1">
        <property type="nucleotide sequence ID" value="XM_031669020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MPM1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001681"/>
    <dbReference type="Ensembl" id="ENSPANT00000005968.3">
        <property type="protein sequence ID" value="ENSPANP00000001681.1"/>
        <property type="gene ID" value="ENSPANG00000014692.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007933"/>
    <dbReference type="KEGG" id="panu:101007933"/>
    <dbReference type="CTD" id="80757"/>
    <dbReference type="eggNOG" id="ENOG502S0WC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003866"/>
    <dbReference type="HOGENOM" id="CLU_076106_0_0_1"/>
    <dbReference type="OMA" id="QATLWEP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014692">
        <property type="expression patterns" value="Expressed in amygdala and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042314">
        <property type="entry name" value="TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="318" mass="35627" checksum="8D0BD941B070CE07" modified="2014-11-26" version="1">MVLPPPDRRHVCLTTLVIMGSMAVMDAYLVEQNQGPRKIGVCIIVLVGDVCFLLVLRYVAVWVGAEVRTAKRGYAMILWFLYIFVLEIKLYFIFQNYKAARRGAADPVARKALTLLLSVCVPGLFLLLVALDRMEYVRTFRKREDLRGRLFWVALDLLDLLDMQASLWEPPRSGLPLWAEGLTFFYCYMLLLVLPCVALSEVSMQGEHIAPQKMMLYPVLSLATVNVVAVLARAANMALFRDSRVSAIFVGKNVVALATKACTFLEYRRQVRDFPPPALALELQPPPPQRNSVPPPPPLHGPPGRPHGSSPTRDPLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQE4</accession>
    <name>A0A096MQE4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PPP1R14B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Inhibitor of PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MQE4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001971"/>
    <dbReference type="Ensembl" id="ENSPANT00000012086.3">
        <property type="protein sequence ID" value="ENSPANP00000001971.3"/>
        <property type="gene ID" value="ENSPANG00000012133.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182985"/>
    <dbReference type="HOGENOM" id="CLU_1312711_0_0_1"/>
    <dbReference type="OMA" id="RLNIEEW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012133">
        <property type="expression patterns" value="Expressed in aorta and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQE4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.220:FF:000001">
        <property type="entry name" value="Phosphatase 1, regulatory (Inhibitor) subunit 14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF5">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05361">
        <property type="entry name" value="PP1_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 5" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001971.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="147" mass="15911" checksum="2932A4EA9F312451" modified="2022-05-25" version="3">MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGADDEGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLDMESDDARAARVKELLVDCYKPTEAFISGLLDKIRGMQKLSTPQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRD9</accession>
    <name>A0A096MRD9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">KLF transcription factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KLF8</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031516667.1">
        <property type="nucleotide sequence ID" value="XM_031660807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRD9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002339"/>
    <dbReference type="Ensembl" id="ENSPANT00000009479.3">
        <property type="protein sequence ID" value="ENSPANP00000002339.2"/>
        <property type="gene ID" value="ENSPANG00000011601.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997235"/>
    <dbReference type="KEGG" id="panu:100997235"/>
    <dbReference type="CTD" id="11279"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161062"/>
    <dbReference type="HOGENOM" id="CLU_002678_33_0_1"/>
    <dbReference type="OMA" id="KMTSPPF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011601">
        <property type="expression patterns" value="Expressed in mesenteric fat pad and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRD9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21440">
        <property type="entry name" value="KLF8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000563">
        <property type="entry name" value="Krueppel-like factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF46">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002339.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="359" mass="39260" checksum="2C0F5B13C6E1D44E" modified="2022-05-25" version="2">MVDMDQLINNLEVQLNSEGGSMQVFKQVTSSVRNRDPSEIEYRSNMTSPTLLDANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAPLQPASMLQAPVRPPKPQSAPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSSQSTGGQQILHVIHTIPSVSLPNKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRM1</accession>
    <name>A0A096MRM1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBZ2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031519557.1">
        <property type="nucleotide sequence ID" value="XM_031663697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRM1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002423"/>
    <dbReference type="Ensembl" id="ENSPANT00000018510.3">
        <property type="protein sequence ID" value="ENSPANP00000002423.3"/>
        <property type="gene ID" value="ENSPANG00000012880.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021061"/>
    <dbReference type="CTD" id="199990"/>
    <dbReference type="eggNOG" id="ENOG502SE5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010531"/>
    <dbReference type="HOGENOM" id="CLU_122192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012880">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRM1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052689">
        <property type="entry name" value="FA_core_complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031491">
        <property type="entry name" value="FANCA_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031490">
        <property type="entry name" value="UBZ2_FAAP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37862">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37862:SF1">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15751">
        <property type="entry name" value="FANCA_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15750">
        <property type="entry name" value="UBZ_FAAP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51906">
        <property type="entry name" value="ZF_UBZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBZ2-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002423.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="179" mass="19843" checksum="38A9E1E5E93C1F7E" modified="2022-05-25" version="3">MEAARRPRLGLSRRRPPPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELTLDHEVPPLPAFPGQEPRCGPEPTEAFTVGPKTFSWTPFPPDLWSPGRSYRLLRGAGGHLESPARSLPQRPAPDPCRAPRVEQQPSVEGAALRRCPMCQKEFGPRLTQLDVDSHLAQCLAESTEDVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MT72</accession>
    <name>A0A096MT72_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase H+ transporting V1 subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ATP6V1E2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021780959.1">
        <property type="nucleotide sequence ID" value="XM_021925267.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511391.1">
        <property type="nucleotide sequence ID" value="XM_031655531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511392.1">
        <property type="nucleotide sequence ID" value="XM_031655532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511393.1">
        <property type="nucleotide sequence ID" value="XM_031655533.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511394.1">
        <property type="nucleotide sequence ID" value="XM_031655534.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511395.1">
        <property type="nucleotide sequence ID" value="XM_031655535.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511396.1">
        <property type="nucleotide sequence ID" value="XM_031655536.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511397.1">
        <property type="nucleotide sequence ID" value="XM_031655537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511398.1">
        <property type="nucleotide sequence ID" value="XM_031655538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511399.1">
        <property type="nucleotide sequence ID" value="XM_031655539.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511400.1">
        <property type="nucleotide sequence ID" value="XM_031655540.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511401.1">
        <property type="nucleotide sequence ID" value="XM_031655541.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031511402.1">
        <property type="nucleotide sequence ID" value="XM_031655542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MT72"/>
    <dbReference type="SMR" id="A0A096MT72"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002996"/>
    <dbReference type="Ensembl" id="ENSPANT00000021320.3">
        <property type="protein sequence ID" value="ENSPANP00000002996.2"/>
        <property type="gene ID" value="ENSPANG00000005031.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023443"/>
    <dbReference type="KEGG" id="panu:101023443"/>
    <dbReference type="CTD" id="90423"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002730"/>
    <dbReference type="HOGENOM" id="CLU_073641_2_0_1"/>
    <dbReference type="OMA" id="CRPQDHL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005031">
        <property type="expression patterns" value="Expressed in putamen and 53 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2320.30:FF:000001">
        <property type="entry name" value="V-type proton atpase subunit e 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002996.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="226" mass="26060" checksum="E733F6CA74F9172B" modified="2018-02-28" version="2">MALSDVDVKKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSTMRNQARLKVLRARDDLISDLLSEAKLRLSRIVENPEVYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKHVEVQIDQEAYLAVNAAGGVEVYSGNQRIKVSNTLESRLDLSAKEKMPEIRMALFGANANRKFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVD4</accession>
    <name>A0A096MVD4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dimethylglycine dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="13">1.5.8.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ME2GLYDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DMGDH</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:52856"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="Rhea" id="RHEA-COMP:13257"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58251"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:136572"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="1.5.8.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.8.4" evidence="13"/>
    <dbReference type="RefSeq" id="XP_003899904.1">
        <property type="nucleotide sequence ID" value="XM_003899855.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MVD4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003809"/>
    <dbReference type="Ensembl" id="ENSPANT00000022726.3">
        <property type="protein sequence ID" value="ENSPANP00000003809.1"/>
        <property type="gene ID" value="ENSPANG00000016060.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021742"/>
    <dbReference type="KEGG" id="panu:101021742"/>
    <dbReference type="CTD" id="29958"/>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158176"/>
    <dbReference type="HOGENOM" id="CLU_007884_11_1_1"/>
    <dbReference type="OMA" id="NGWERPN"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016060">
        <property type="expression patterns" value="Expressed in metanephros cortex and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047865">
        <property type="term" value="F:dimethylglycine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042426">
        <property type="term" value="P:choline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000005">
        <property type="entry name" value="dimethylglycine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000005">
        <property type="entry name" value="Dimethylglycine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="52"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="20">
        <location>
            <begin position="417"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="18">
        <location>
            <begin position="480"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="19">
        <location>
            <begin position="770"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="866" mass="96971" checksum="AD442FA101A2393C" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MW79</accession>
    <name>A0A096MW79_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane spanning 4-domains A13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MS4A13</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909809.1">
        <property type="nucleotide sequence ID" value="XM_003909760.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009184199.1">
        <property type="nucleotide sequence ID" value="XM_009185935.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009184200.1">
        <property type="nucleotide sequence ID" value="XM_009185936.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009184201.1">
        <property type="nucleotide sequence ID" value="XM_009185937.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009184202.1">
        <property type="nucleotide sequence ID" value="XM_009185938.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009184204.1">
        <property type="nucleotide sequence ID" value="XM_009185940.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009184205.1">
        <property type="nucleotide sequence ID" value="XM_009185941.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017803831.1">
        <property type="nucleotide sequence ID" value="XM_017948342.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031509484.1">
        <property type="nucleotide sequence ID" value="XM_031653624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MW79"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004125"/>
    <dbReference type="Ensembl" id="ENSPANT00000013584.3">
        <property type="protein sequence ID" value="ENSPANP00000004125.3"/>
        <property type="gene ID" value="ENSPANG00000016294.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010426"/>
    <dbReference type="KEGG" id="panu:101010426"/>
    <dbReference type="CTD" id="503497"/>
    <dbReference type="eggNOG" id="ENOG502RTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015662"/>
    <dbReference type="HOGENOM" id="CLU_144238_0_0_1"/>
    <dbReference type="OMA" id="FNVLMWY"/>
    <dbReference type="OrthoDB" id="9451513at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016294">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF42">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004125.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="173" mass="19538" checksum="B59778420D629255" modified="2022-05-25" version="3">MACVHSKISTANSLVLGAIQIMIGIFHVFMWYFLLVLYKGQIKGSFGMYEPITYKTGCTLWGIFFIIAGVFIIGVTRYPTRSAIICTLIMNIFCIITTITAVTLTIIELSHFNSPSYRNYGQAKLGREVSRILLFFYPLEFSVALTYSICSCSNLFRRQSDLTSVVEEAENTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXD8</accession>
    <name>A0A096MXD8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-aminomuconic semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aldehyde dehydrogenase family 8 member A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALDH8A1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-aminomuconate 6-semialdehyde + NAD(+) + H2O = (2Z,4E)-2-aminomuconate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14469"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:77634"/>
            <dbReference type="ChEBI" id="CHEBI:77859"/>
            <dbReference type="EC" id="1.2.1.32"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid degradation; L-kynurenine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.32" evidence="9"/>
    <dbReference type="RefSeq" id="XP_003898199.1">
        <property type="nucleotide sequence ID" value="XM_003898150.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MXD8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004551"/>
    <dbReference type="Ensembl" id="ENSPANT00000000129.3">
        <property type="protein sequence ID" value="ENSPANP00000004551.1"/>
        <property type="gene ID" value="ENSPANG00000022180.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012817"/>
    <dbReference type="KEGG" id="panu:101012817"/>
    <dbReference type="CTD" id="64577"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156799"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_1"/>
    <dbReference type="OMA" id="PMPIAAW"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022180">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MXD8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047102">
        <property type="term" value="F:aminomuconate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001758">
        <property type="term" value="F:retinal dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042904">
        <property type="term" value="P:9-cis-retinoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07093">
        <property type="entry name" value="ALDH_F8_HMSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000021">
        <property type="entry name" value="Aldehyde dehydrogenase family 8 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="487" mass="53315" checksum="5EBABDB31ACAC22E" modified="2014-11-26" version="1">MAGTKALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPGWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSILHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAIAAGNTVVAKPSELTSVTAWMLCTLLDKAGVPPGVVNIVFGTGPTVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYTEFLKRFVEATRKWKVGIPSDPLASMGALISKAHLEKVRSYIKRALAEGAQIWCGEGVDKLNLPARSQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0A3</accession>
    <name>A0A096N0A3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-alanine-activating enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-CoA synthetase family member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AASDH</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898914.2">
        <property type="nucleotide sequence ID" value="XM_003898865.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009205309.2">
        <property type="nucleotide sequence ID" value="XM_009207045.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009205311.2">
        <property type="nucleotide sequence ID" value="XM_009207047.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0A3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005675"/>
    <dbReference type="Ensembl" id="ENSPANT00000009177.4">
        <property type="protein sequence ID" value="ENSPANP00000005675.3"/>
        <property type="gene ID" value="ENSPANG00000018913.4"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="expression patterns" value="Expressed in adrenal medulla and 64 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
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        <property type="term" value="P:fatty acid metabolic process"/>
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        <property type="entry name" value="acyl-CoA synthetase family member 4"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="AASDH_AMP"/>
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    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
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    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="Beta-prop_ACSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="553"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005675.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122445" checksum="AC28AA4338B47966" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5Y0</accession>
    <name>A0A096N5Y0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain 34C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANKRD34C</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901329.1">
        <property type="nucleotide sequence ID" value="XM_003901280.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N5Y0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007854"/>
    <dbReference type="Ensembl" id="ENSPANT00000019380.3">
        <property type="protein sequence ID" value="ENSPANP00000007854.1"/>
        <property type="gene ID" value="ENSPANG00000010307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006078"/>
    <dbReference type="KEGG" id="panu:101006078"/>
    <dbReference type="CTD" id="390616"/>
    <dbReference type="eggNOG" id="ENOG502QW3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00880000138051"/>
    <dbReference type="HOGENOM" id="CLU_042805_0_0_1"/>
    <dbReference type="OMA" id="EQQNTVF"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010307">
        <property type="expression patterns" value="Expressed in habenula and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF6">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 34C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="535" mass="58375" checksum="4605ACC172A9DFF6" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N794</accession>
    <name>A0A096N794_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Proton-coupled zinc antiporter SLC30A9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 30 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc transporter 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SLC30A9</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health. In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017814152.1">
        <property type="nucleotide sequence ID" value="XM_017958663.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N794"/>
    <dbReference type="Ensembl" id="ENSPANT00000019749.3">
        <property type="protein sequence ID" value="ENSPANP00000008389.1"/>
        <property type="gene ID" value="ENSPANG00000024558.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016910"/>
    <dbReference type="CTD" id="10463"/>
    <dbReference type="eggNOG" id="KOG2802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008346"/>
    <dbReference type="HOGENOM" id="CLU_021126_3_0_1"/>
    <dbReference type="OMA" id="HSMFSEC"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024558">
        <property type="expression patterns" value="Expressed in olfactory bulb and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N794">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21078">
        <property type="entry name" value="NTD_ZNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000004">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000002">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="24">
        <location>
            <begin position="241"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="569" mass="63764" checksum="ACC4C00801F6C038" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7R6</accession>
    <name>A0A096N7R6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid amide hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAAH2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096N7R6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008621"/>
    <dbReference type="Ensembl" id="ENSPANT00000019172.3">
        <property type="protein sequence ID" value="ENSPANP00000008621.3"/>
        <property type="gene ID" value="ENSPANG00000005116.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162502"/>
    <dbReference type="HOGENOM" id="CLU_009600_16_1_1"/>
    <dbReference type="OMA" id="YLMWASA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005116">
        <property type="expression patterns" value="Expressed in pancreas and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008621.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="304" mass="34112" checksum="628349E5FD6F495B" modified="2022-05-25" version="3">MKFFIVLYLEKKIHLSNLSGVVPNKGQFPMAVGGQELFQCTGPMCRYAEDLAPMLKVMAGPGIKRLKLDTKVHLKDLKFYWMEHDGGSFLMSKVEQDLILAQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVNPLWELIKWCLGLSVYTIPSIGLALLEEKLKYNNEKYQKFKAVEESLRKELVEMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFNALGLPVTQCPLGLNVKGLPLGIQVVAGPFHDHLTLAVAQYLEKTFGGWVCPGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N859</accession>
    <name>A0A096N859_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">POU class 3 homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">POU3F1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N859"/>
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    <dbReference type="Ensembl" id="ENSPANT00000015179.3">
        <property type="protein sequence ID" value="ENSPANP00000008784.3"/>
        <property type="gene ID" value="ENSPANG00000009765.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163458"/>
    <dbReference type="HOGENOM" id="CLU_013065_1_0_1"/>
    <dbReference type="OMA" id="QLCHRPP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022011">
        <property type="term" value="P:myelination in peripheral nervous system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF75">
        <property type="entry name" value="POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="463"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="465"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008784.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="577" mass="58302" checksum="47AE3CE37ED2AA06" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8R1</accession>
    <name>A0A096N8R1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell division cycle-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Kinetochore protein Nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NUF2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893524.1">
        <property type="nucleotide sequence ID" value="XM_003893475.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003893525.1">
        <property type="nucleotide sequence ID" value="XM_003893476.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009190996.1">
        <property type="nucleotide sequence ID" value="XM_009192732.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8R1"/>
    <dbReference type="SMR" id="A0A096N8R1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008992"/>
    <dbReference type="Ensembl" id="ENSPANT00000014579.3">
        <property type="protein sequence ID" value="ENSPANP00000008992.1"/>
        <property type="gene ID" value="ENSPANG00000015339.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008799"/>
    <dbReference type="KEGG" id="panu:101008799"/>
    <dbReference type="CTD" id="83540"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004199"/>
    <dbReference type="HOGENOM" id="CLU_589957_0_0_1"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015339">
        <property type="expression patterns" value="Expressed in duodenum and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N8R1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000001">
        <property type="entry name" value="NDC80 kinetochore complex component NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="251"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="464" mass="54304" checksum="250BFED5AD87153B" modified="2014-11-26" version="1">METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA69</accession>
    <name>A0A096NA69_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF251</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NA69"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009573"/>
    <dbReference type="Ensembl" id="ENSPANT00000023706.3">
        <property type="protein sequence ID" value="ENSPANP00000009573.2"/>
        <property type="gene ID" value="ENSPANG00000010537.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163332"/>
    <dbReference type="HOGENOM" id="CLU_002678_57_2_1"/>
    <dbReference type="OMA" id="IHIKKIF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010537">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000555">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003341">
        <property type="entry name" value="Zinc finger protein 1152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002392">
        <property type="entry name" value="Zinc finger protein 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002129">
        <property type="entry name" value="Zinc finger protein 304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001336">
        <property type="entry name" value="Zinc finger protein 334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000878">
        <property type="entry name" value="Zinc finger protein 544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009573.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="671" mass="75686" checksum="0E61952C7AB80F02" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAR2</accession>
    <name>A0A096NAR2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyrotropin-releasing hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Thyroliberin receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TRHR</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003903121.1">
        <property type="nucleotide sequence ID" value="XM_003903072.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021798254.1">
        <property type="nucleotide sequence ID" value="XM_021942562.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NAR2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009806"/>
    <dbReference type="Ensembl" id="ENSPANT00000026881.3">
        <property type="protein sequence ID" value="ENSPANP00000009806.1"/>
        <property type="gene ID" value="ENSPANG00000017053.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103887040"/>
    <dbReference type="KEGG" id="panu:103887040"/>
    <dbReference type="CTD" id="7201"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286932"/>
    <dbReference type="HOGENOM" id="CLU_009579_6_5_1"/>
    <dbReference type="OMA" id="NCKQKPA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017053">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004997">
        <property type="term" value="F:thyrotropin-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14995">
        <property type="entry name" value="7tmA_TRH-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000186">
        <property type="entry name" value="thyrotropin-releasing hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002120">
        <property type="entry name" value="TRH_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061:SF2">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00751">
        <property type="entry name" value="THYROLIBRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01846">
        <property type="entry name" value="TRHRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="42"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="398" mass="45041" checksum="966776B6A9BD3A49" modified="2014-11-26" version="1">MENETVSELNQTQLQPRAAVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNLNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDAYLSATKVSFDDTCLASEVSFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NC95</accession>
    <name>A0A096NC95_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Coagulation factor XI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">F11</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899481.2">
        <property type="nucleotide sequence ID" value="XM_003899432.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NC95"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010436"/>
    <dbReference type="MEROPS" id="S01.213"/>
    <dbReference type="Ensembl" id="ENSPANT00000021578.3">
        <property type="protein sequence ID" value="ENSPANP00000010436.2"/>
        <property type="gene ID" value="ENSPANG00000007483.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004898"/>
    <dbReference type="KEGG" id="panu:101004898"/>
    <dbReference type="CTD" id="2160"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158569"/>
    <dbReference type="HOGENOM" id="CLU_031604_0_0_1"/>
    <dbReference type="OMA" id="QNCRHSV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007483">
        <property type="expression patterns" value="Expressed in liver and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031639">
        <property type="term" value="P:plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051919">
        <property type="term" value="P:positive regulation of fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.4.10:FF:000001">
        <property type="entry name" value="Coagulation factor XI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00005">
        <property type="entry name" value="APPLEDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00495">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035297836" evidence="15">
        <location>
            <begin position="19"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="17">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="17">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="17">
        <location>
            <begin position="200"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="17">
        <location>
            <begin position="291"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="388"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010436.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="625" mass="70091" checksum="94C67CE7722315B1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDA4</accession>
    <name>A0A096NDA4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009199202.1">
        <property type="nucleotide sequence ID" value="XM_009200938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDA4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010848"/>
    <dbReference type="Ensembl" id="ENSPANT00000016190.3">
        <property type="protein sequence ID" value="ENSPANP00000010848.2"/>
        <property type="gene ID" value="ENSPANG00000012872.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998567"/>
    <dbReference type="CTD" id="377047"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161932"/>
    <dbReference type="HOGENOM" id="CLU_006842_0_4_1"/>
    <dbReference type="OMA" id="GNMICAT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012872">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 27 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000105">
        <property type="entry name" value="Inactive serine protease 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000004">
        <property type="entry name" value="Tryptase gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010848.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="261" mass="29297" checksum="6D2B939619630841" modified="2018-02-28" version="2">MTRHWPWEVSLRMENKHVCGGALIDPSWVVTAAHCIQGTKEYSVVLGTSKLQPMNFSRALQVPVRDIIMHPKYWGRTFIMGDVALVHLQAPVTFSEYVQPICLPEPNFNLKVGTQCWVTGWSQVKQRFSANSTLTPELQEAEVFIMDNKRCDQHYHKKSFFPSVVPLVLGDMICATNYGENLCYGDSGGPLACEVEGRWILAGVLSWEKACAKAQNPGVYTRVTKYTKWIKKQMSNGAFSGPCASACLLFLCWLLQPQMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEQ2</accession>
    <name>A0A096NEQ2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine rich secretory protein LCCL domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRISPLD1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902930.1">
        <property type="nucleotide sequence ID" value="XM_003902881.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NEQ2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011379"/>
    <dbReference type="Ensembl" id="ENSPANT00000021497.3">
        <property type="protein sequence ID" value="ENSPANP00000011379.1"/>
        <property type="gene ID" value="ENSPANG00000023611.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000286"/>
    <dbReference type="KEGG" id="panu:101000286"/>
    <dbReference type="CTD" id="83690"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156473"/>
    <dbReference type="HOGENOM" id="CLU_042287_0_0_1"/>
    <dbReference type="OMA" id="MVWDVEL"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023611">
        <property type="expression patterns" value="Expressed in aorta and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NEQ2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18813">
        <property type="entry name" value="CAP_CRISPLD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000001">
        <property type="entry name" value="Cysteine-rich secretory protein LCCL domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.130.20:FF:000001">
        <property type="entry name" value="Cysteine-rich secretory protein LCCL domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF9">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN LCCL DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LCCL" evidence="8">
        <location>
            <begin position="289"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="8">
        <location>
            <begin position="390"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="500" mass="56703" checksum="BBF27EA6143BE609" modified="2014-11-26" version="1">MKCTAREWLRVTTVLFMARAIPAMVVPNATLLEKLLEKYMDEDGEWWTAKQRGKRAITDNDMQSILDLHNKLRSQVYPTASNMEYMTWDVELERSAESWAESCLWEHGPASLLPSIGQNLGAHWGRYRPPTFHVQAWYDEVKDFSYPYEHECNPYCPFRCSGPVCTHYTQVVWATSSRIGCAINLCNNMNIWGQIWPKAVYLVCNYSPKGNWWGHAPYKHGRPCSACPPSFGGGCRENLCYKEGSDGYYTPREEETNEIERQQSQVHDTHVQTRSDDSSRNEVISTQQMSQIVSCEVRLRDQCKGTTCNRYECPAGCVDSKAKVIGSVHYEMQSSICRAAIHYGIIDNDGGWVDITRQGRKHYFIKSNRNGIQTIGKYQSANSFTVSKVTVQAVTCETTVEQLCPFHKPASHCPRVYCPRNCMQANPHYARVIGTRVYSDLSSICRAAVHAGVVRNHGGYVDVMPVDKRKTYIASFQNGIFSESLQNPPGGKAFRVFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEZ6</accession>
    <name>A0A096NEZ6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane p24 trafficking protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMED4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896088.1">
        <property type="nucleotide sequence ID" value="XM_003896039.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NEZ6"/>
    <dbReference type="SMR" id="A0A096NEZ6"/>
    <dbReference type="Ensembl" id="ENSPANT00000006356.3">
        <property type="protein sequence ID" value="ENSPANP00000011484.3"/>
        <property type="gene ID" value="ENSPANG00000041568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101007632"/>
    <dbReference type="KEGG" id="panu:101007632"/>
    <dbReference type="CTD" id="222068"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159012"/>
    <dbReference type="HOGENOM" id="CLU_066963_2_2_1"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002446">
        <property type="expression patterns" value="Expressed in pineal body and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NEZ6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263115" evidence="10">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011484.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="227" mass="26114" checksum="9A5E8B428D41E57E" modified="2022-05-25" version="3">MAGVRAGLLRAMGRQVLLLLALCATGARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFK2</accession>
    <name>A0A096NFK2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Exostosin-like 1</fullName>
            <ecNumber evidence="4">2.4.1.224</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Exostosin-L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Multiple exostosis-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">EXTL1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-O-{[(1-&gt;4)-beta-D-GlcA-(1-&gt;4)-alpha-D-GlcNAc](n)-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1-&gt;4)-beta-D-GlcA-(1-&gt;4)-alpha-D-GlcNAc](n)-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16213"/>
            <dbReference type="Rhea" id="RHEA-COMP:12621"/>
            <dbReference type="Rhea" id="RHEA-COMP:12623"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132415"/>
            <dbReference type="ChEBI" id="CHEBI:132416"/>
            <dbReference type="EC" id="2.4.1.224"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003891421.2">
        <property type="nucleotide sequence ID" value="XM_003891372.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NFK2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011703"/>
    <dbReference type="Ensembl" id="ENSPANT00000016691.3">
        <property type="protein sequence ID" value="ENSPANP00000011703.2"/>
        <property type="gene ID" value="ENSPANG00000001282.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009465"/>
    <dbReference type="KEGG" id="panu:101009465"/>
    <dbReference type="CTD" id="2134"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161960"/>
    <dbReference type="HOGENOM" id="CLU_013906_4_0_1"/>
    <dbReference type="OMA" id="QWNGGKN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001282">
        <property type="expression patterns" value="Expressed in amygdala and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000109">
        <property type="entry name" value="Exostosin like glycosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF3">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="20">
        <location>
            <begin position="94"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="21">
        <location>
            <begin position="418"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011703.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="675" mass="74247" checksum="C8713D68E36D9649" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGW3</accession>
    <name>A0A096NGW3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serrate RNA effector molecule homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arsenite-resistance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SRRT</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009200991.1">
        <property type="nucleotide sequence ID" value="XM_009202727.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGW3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012202"/>
    <dbReference type="Ensembl" id="ENSPANT00000000528.4">
        <property type="protein sequence ID" value="ENSPANP00000012202.3"/>
        <property type="gene ID" value="ENSPANG00000020763.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101016145"/>
    <dbReference type="CTD" id="51593"/>
    <dbReference type="eggNOG" id="KOG2295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005492"/>
    <dbReference type="HOGENOM" id="CLU_008560_0_0_1"/>
    <dbReference type="OMA" id="FEDKIMQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020763">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NGW3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140262">
        <property type="term" value="F:mRNA cap binding complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000593">
        <property type="entry name" value="Serrate RNA effector molecule homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="10">
        <location>
            <begin position="153"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="9">
        <location>
            <begin position="646"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012202.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="876" mass="100638" checksum="5CE80D5E28B21D99" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHI2</accession>
    <name>A0A096NHI2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Death domain-associated protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Daxx</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">DAXX</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
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        <subcellularLocation>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
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        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DAXX family.</text>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIU2</accession>
    <name>A0A096NIU2_PAPAN</name>
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        <recommendedName>
            <fullName evidence="14">Adhesion G protein-coupled receptor G3</fullName>
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        <alternativeName>
            <fullName evidence="15">G-protein coupled receptor 97</fullName>
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        <name evidence="20" type="primary">ADGRG3</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with PRTN3; this interaction induces the activation of PAR2. Interacts with GNAO1 (when palmitoylated).</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="term" value="P:negative regulation of non-canonical NF-kappaB signal transduction"/>
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    <feature type="signal peptide" evidence="17">
        <location>
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        </location>
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    <feature type="chain" id="PRO_5035245574" description="Adhesion G protein-coupled receptor G3" evidence="17">
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            <begin position="20"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="477"/>
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            <begin position="505"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="550" mass="60896" checksum="B09055D66BF9FB59" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NJZ6</accession>
    <name>A0A096NJZ6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">XRCC3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009210578.1">
        <property type="nucleotide sequence ID" value="XM_009212314.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009210580.1">
        <property type="nucleotide sequence ID" value="XM_009212316.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031523640.1">
        <property type="nucleotide sequence ID" value="XM_031667780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NJZ6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013300"/>
    <dbReference type="Ensembl" id="ENSPANT00000026365.3">
        <property type="protein sequence ID" value="ENSPANP00000013300.1"/>
        <property type="gene ID" value="ENSPANG00000015712.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022574"/>
    <dbReference type="KEGG" id="panu:101022574"/>
    <dbReference type="CTD" id="7517"/>
    <dbReference type="eggNOG" id="KOG1564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151053"/>
    <dbReference type="HOGENOM" id="CLU_041732_1_0_1"/>
    <dbReference type="OMA" id="WANQVTV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015712">
        <property type="expression patterns" value="Expressed in thymus and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001223">
        <property type="entry name" value="X-ray repair cross complementing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47789">
        <property type="entry name" value="C-terminal domain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="15">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="346" mass="37839" checksum="9C5C5E4CBDCA34DA" modified="2014-11-26" version="1">MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALHLHQQKERFPAQHQRLSLGCPVLDSLLCGGLPLDGITELAGRSSVGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAPRARRLQSLGAALRELSSAFQSPVLCINQVTEAMEEQSAAHGPLGFWDERASPALGITWANQLLVRLLAERLREEEAALGGPARTLRVLFAPHLPPSSCSYTISAEGVRGTPGTQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPN5</accession>
    <name>A0A096NPN5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.386</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HEN1 methyltransferase homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HENMT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="12"/>
    <dbReference type="RefSeq" id="XP_003892349.1">
        <property type="nucleotide sequence ID" value="XM_003892300.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212476.1">
        <property type="nucleotide sequence ID" value="XM_009214212.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212486.1">
        <property type="nucleotide sequence ID" value="XM_009214222.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212490.1">
        <property type="nucleotide sequence ID" value="XM_009214226.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NPN5"/>
    <dbReference type="Ensembl" id="ENSPANT00000013260.3">
        <property type="protein sequence ID" value="ENSPANP00000014966.1"/>
        <property type="gene ID" value="ENSPANG00000013358.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026366"/>
    <dbReference type="KEGG" id="panu:101026366"/>
    <dbReference type="CTD" id="113802"/>
    <dbReference type="eggNOG" id="KOG1045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004798"/>
    <dbReference type="HOGENOM" id="CLU_044646_0_0_1"/>
    <dbReference type="OrthoDB" id="2154311at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013358">
        <property type="expression patterns" value="Expressed in testis and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NPN5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000124">
        <property type="entry name" value="HEN methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="393" mass="44733" checksum="604F4873EB4DC2B2" modified="2014-11-26" version="1">MEENNLQCSSVVDGNFEEVPRETAIQFKPPLYRQRYQFVKNLVDQHEPKKVADLGCGDTSLLRLLKVNPCIELLVGVDINEDKLRWRGDSLAPFMGDFLKPRDLNLTIILYHGSVVERDSRLLGFDLITCIELIEHLDSGDLARFPEVVFGYLSPSMIVISTPNSEFNPLFPSVTLRDSDHKFEWTRMEFQTWALYVANRYDYSVEFTGVGEPPAGAENVGYCTQIGIFQKNRGKATEACVSEQHDQHVYKAVFTTSYPSLQQERFFKLVLVNEVSQQVESLRVSHLPRRKEQDGERGDEPKDIGGSKAPVPCFGPVFTEVEKAKIENSPKPFCVGDKFFVPLQRLLAYPRLNRLCANEEMMRSVIADSIPLSSDGSAVVTDLYNYFDEQFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRS9</accession>
    <name>A0A096NRS9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">snRNA-activating protein complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNA-activating protein complex 190 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SNAPC4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017804961.2">
        <property type="nucleotide sequence ID" value="XM_017949472.3"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000015749"/>
    <dbReference type="Ensembl" id="ENSPANT00000028663.3">
        <property type="protein sequence ID" value="ENSPANP00000015749.3"/>
        <property type="gene ID" value="ENSPANG00000026126.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997302"/>
    <dbReference type="CTD" id="6621"/>
    <dbReference type="GeneTree" id="ENSGT00940000160404"/>
    <dbReference type="HOGENOM" id="CLU_004641_0_0_1"/>
    <dbReference type="OMA" id="MAFHQTK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026126">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NRS9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000393">
        <property type="entry name" value="Small nuclear RNA activating complex polypeptide 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000314">
        <property type="entry name" value="Small nuclear RNA-activating complex, polypeptide 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000321">
        <property type="entry name" value="Small nuclear RNA-activating complex, polypeptide 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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            <begin position="289"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
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            <begin position="289"/>
            <end position="341"/>
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    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
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            <begin position="344"/>
            <end position="395"/>
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    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="396"/>
            <end position="451"/>
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    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="396"/>
            <end position="447"/>
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            <begin position="399"/>
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    <feature type="domain" description="Myb-like" evidence="12">
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            <begin position="448"/>
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            <begin position="451"/>
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            <begin position="452"/>
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            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="501"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025193"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00071222"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00079701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="1458" mass="157638" checksum="44516D93E188E0B4" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSL1</accession>
    <name>A0A096NSL1_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">ARF like GTPase 6 interacting protein 6</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">ARL6IP6</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000018067.3"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
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        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="ARL6IP6"/>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR28640:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15062">
        <property type="entry name" value="ARL6IP6"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="108"/>
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            <begin position="151"/>
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            <begin position="198"/>
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            <begin position="1"/>
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            <begin position="38"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    <sequence length="226" mass="24586" checksum="CBEE62F0151039D6" modified="2014-11-26" version="1">MSLAESGWRSALRRRRPGTPGPVAGPTYSSFTQGDSWGEGEVDEEEGCDQVARDLRAEFSAGAWSEPRKGSLLPPDGDGSPVLPDKRNGIFPAAAGSRTQPRRWPVQVLSILCSLLFAILLAFLLAIAYLIVKELHADNLKNEDVIDTGLLGFWTLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKLTGHSFHMGYSMAILNGIVAALTVAWCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUP1</accession>
    <name>A0A096NUP1_PAPAN</name>
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        <recommendedName>
            <fullName evidence="9">Ly6/PLAUR domain-containing protein 3</fullName>
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        <name evidence="13" type="primary">LYPD3</name>
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        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003919221.2">
        <property type="nucleotide sequence ID" value="XM_003919172.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUP1"/>
    <dbReference type="Ensembl" id="ENSPANT00000024910.3">
        <property type="protein sequence ID" value="ENSPANP00000016765.2"/>
        <property type="gene ID" value="ENSPANG00000026276.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010493"/>
    <dbReference type="KEGG" id="panu:101010493"/>
    <dbReference type="CTD" id="27076"/>
    <dbReference type="eggNOG" id="ENOG502RYZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153599"/>
    <dbReference type="HOGENOM" id="CLU_062960_0_0_1"/>
    <dbReference type="OMA" id="VQDELCT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026276">
        <property type="expression patterns" value="Expressed in cornea and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0034392">
        <property type="term" value="P:negative regulation of smooth muscle cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23562">
        <property type="entry name" value="TFP_LU_ECD_LYPD3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23563">
        <property type="entry name" value="TFP_LU_ECD_LYPD3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000016">
        <property type="entry name" value="LY6/PLAUR domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000017">
        <property type="entry name" value="Ly6/PLAUR domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10624:SF8">
        <property type="entry name" value="LY6_PLAUR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10624">
        <property type="entry name" value="UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035189693" description="Ly6/PLAUR domain-containing protein 3" evidence="11">
        <location>
            <begin position="32"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="12">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016765.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="347" mass="36070" checksum="743409EC82649CB0" modified="2022-05-25" version="2">MDPARKAGAQAVIWNAGWLLLLLLLCRGAQALECYSCVQKADDGCSPHKMKTVKCAPGVDVCTEAVGAVETIHGQFSMAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYNGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPLPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTSRQGAEHEASQDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNRGGVAPTAGLAALLLAVAAGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUT2</accession>
    <name>A0A096NUT2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LRR1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the probable ECS(LRR1) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and LRR1. Interacts with CUL2, RBX1, ELOB and ELOC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003901813.1">
        <property type="nucleotide sequence ID" value="XM_003901764.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUT2"/>
    <dbReference type="SMR" id="A0A096NUT2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016807"/>
    <dbReference type="Ensembl" id="ENSPANT00000026300.3">
        <property type="protein sequence ID" value="ENSPANP00000016807.1"/>
        <property type="gene ID" value="ENSPANG00000025547.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998170"/>
    <dbReference type="KEGG" id="panu:100998170"/>
    <dbReference type="CTD" id="122769"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158830"/>
    <dbReference type="HOGENOM" id="CLU_053349_1_0_1"/>
    <dbReference type="OMA" id="GELNDWC"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025547">
        <property type="expression patterns" value="Expressed in ascending colon and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUT2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001222">
        <property type="entry name" value="Leucine rich repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001792">
        <property type="entry name" value="Leucine-rich repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF52">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="414" mass="46717" checksum="5E2984A8FF4FB3AA" modified="2014-11-26" version="1">MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPSARAFLLISTLKDKRGTRYELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKANSSSLKGFLSAVRLAHRGCKVDIPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKNLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCQSTLQKSLRTLDLSKNKIKALPVQFCQLQELTNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKILPVIKLQAPLTLLESSARTILYNRIPYGSHIIPFHLCQDLDTAKTCVCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNMGGTEAPIVSYFCSLGCYVNSSDMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUU1</accession>
    <name>A0A096NUU1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Charged multivesicular body protein 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHMP4B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904888.1">
        <property type="nucleotide sequence ID" value="XM_003904839.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUU1"/>
    <dbReference type="SMR" id="A0A096NUU1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016816"/>
    <dbReference type="Ensembl" id="ENSPANT00000013625.3">
        <property type="protein sequence ID" value="ENSPANP00000016816.3"/>
        <property type="gene ID" value="ENSPANG00000018095.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997370"/>
    <dbReference type="KEGG" id="panu:100997370"/>
    <dbReference type="CTD" id="128866"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154663"/>
    <dbReference type="HOGENOM" id="CLU_071097_0_0_1"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018095">
        <property type="expression patterns" value="Expressed in descending colon and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904930">
        <property type="term" value="C:amphisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036438">
        <property type="term" value="P:maintenance of lens transparency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090611">
        <property type="term" value="P:ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046761">
        <property type="term" value="P:viral budding from plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000001">
        <property type="entry name" value="Charged multivesicular body protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF4">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="89"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016816.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="224" mass="24950" checksum="DB1D79DD3803CB2F" modified="2022-05-25" version="3">MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGEEFDEDELMAELEELEQEELDKNLLEISGPETVPLPNVPSIALPSKPAKKKEEEDDDMKELENWAGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NV76</accession>
    <name>A0A096NV76_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LGALS3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <location evidence="3">Secreted</location>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016951.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="283" mass="29992" checksum="9D23A31190E7564B" modified="2022-05-25" version="2">MATKASALLNPHRSLHYCSRSLLVSSRPEPANERKMADNFSLHDALSGSGNPNPQGWPGPWGNQPAGAGGYPGASYPGAYPGQAPPGVYPGQAPPGAYPGAPGAYSGASGVYPGPPSGAGAYPSPGQPSAPGAYPATGPYGAPAGPLSVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFKRRNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVESDHFKVAVNDAHLLQYNHRVKQLNEISQLGISGDIDLTNASYTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NV96</accession>
    <name>A0A096NV96_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UFM1-binding and PCI domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DDRGK1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the UFM1 ribosome E3 ligase (UREL) complex, composed of UFL1, DDRGK1 and CDK5RAP3. Interacts with (unphosphorylated) ERN1/IRE1-alpha; interaction is dependent on UFM1 and takes place in response to endoplasmic reticulum stress, regulating ERN1/IRE1-alpha stability. Interacts with NFKBIA. Interacts with SOX9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905054.1">
        <property type="nucleotide sequence ID" value="XM_003905005.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NV96"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016971"/>
    <dbReference type="Ensembl" id="ENSPANT00000006782.3">
        <property type="protein sequence ID" value="ENSPANP00000016971.1"/>
        <property type="gene ID" value="ENSPANG00000018779.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000873"/>
    <dbReference type="KEGG" id="panu:101000873"/>
    <dbReference type="CTD" id="65992"/>
    <dbReference type="eggNOG" id="KOG3054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017193"/>
    <dbReference type="HOGENOM" id="CLU_059562_0_0_1"/>
    <dbReference type="OMA" id="EFTRECN"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018779">
        <property type="expression patterns" value="Expressed in prefrontal cortex and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NV96">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141185">
        <property type="term" value="F:UFM1-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903895">
        <property type="term" value="P:negative regulation of IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903898">
        <property type="term" value="P:negative regulation of PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900100">
        <property type="term" value="P:positive regulation of plasma cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905552">
        <property type="term" value="P:positive regulation of protein localization to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140501">
        <property type="term" value="P:positive regulation of reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070972">
        <property type="term" value="P:protein localization to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033146">
        <property type="term" value="P:regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="314" mass="35802" checksum="6029DC6133F434B5" modified="2014-11-26" version="1">MVGPVWYLVAAALLVGFILFLTRSRGRAASASQESLHNEELAGAGRVAQPRPLEPEEPRAEGRPRRRRDLGSRLQAQRRAQRVTLAEADENEQEAVILAQEEEDVEKSAETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTITGVIDDRGKFIYITPEELAAVANFIRQRGRVSIAELAQASNSLIAWGREPPAQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVZ9</accession>
    <name>A0A096NVZ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Collagen type I alpha 2 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COL1A2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005788">
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    <dbReference type="GO" id="GO:0005615">
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:31215"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50157"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62622"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3,4-dihydroxyphenylacetaldehyde + NAD(+) + H2O = 3,4-dihydroxyphenylacetate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17612"/>
            <dbReference type="ChEBI" id="CHEBI:27978"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-(trimethylamino)butanal + NAD(+) + H2O = 4-(trimethylamino)butanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17985"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16244"/>
            <dbReference type="ChEBI" id="CHEBI:18020"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58264"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="1.2.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25294"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acrolein + NAD(+) + H2O = acrylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69084"/>
            <dbReference type="ChEBI" id="CHEBI:15368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37080"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69088"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15743"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16425"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanal + NAD(+) + H2O = hexanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>imidazole-4-acetaldehyde + NAD(+) + H2O = imidazole-4-acetate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:31059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57969"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>pentanal + NAD(+) + H2O = pentanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69092"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31011"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:84069"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>propanal + NAD(+) + H2O = propanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67256"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>spermine monoaldehyde + NAD(+) + H2O = N-(2-carboxyethyl)spermidine + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:180903"/>
            <dbReference type="ChEBI" id="CHEBI:180913"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 32">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.19" evidence="10"/>
    <dbReference type="EC" id="1.2.1.3" evidence="8"/>
    <dbReference type="EC" id="1.2.1.46" evidence="14"/>
    <dbReference type="EC" id="1.2.1.47" evidence="9"/>
    <dbReference type="RefSeq" id="XP_003893539.1">
        <property type="nucleotide sequence ID" value="XM_003893490.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031514854.1">
        <property type="nucleotide sequence ID" value="XM_031658994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWR4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017496"/>
    <dbReference type="Ensembl" id="ENSPANT00000025762.3">
        <property type="protein sequence ID" value="ENSPANP00000017496.1"/>
        <property type="gene ID" value="ENSPANG00000010286.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000043628.2">
        <property type="protein sequence ID" value="ENSPANP00000043108.2"/>
        <property type="gene ID" value="ENSPANG00000047258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101016128"/>
    <dbReference type="GeneID" id="116268495"/>
    <dbReference type="KEGG" id="panu:101016128"/>
    <dbReference type="KEGG" id="panu:116268495"/>
    <dbReference type="CTD" id="223"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162687"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="CREGIRM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010286">
        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWR4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047105">
        <property type="term" value="F:4-trimethylammoniobutyraldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
        <property type="term" value="F:aminobutyraldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018467">
        <property type="term" value="F:formaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07090">
        <property type="entry name" value="ALDH_F9_TMBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000019">
        <property type="entry name" value="4-trimethylaminobutyraldehyde dehydrogenase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000016">
        <property type="entry name" value="4-trimethylaminobutyraldehyde dehydrogenase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 32" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="33" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044540399" description="4-trimethylaminobutyraldehyde dehydrogenase" evidence="33">
        <location>
            <begin position="17"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="34">
        <location>
            <begin position="51"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" evidence="31">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050672"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051631"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052427"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017496.1"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043108.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="518" mass="56260" checksum="88ABF33E99EC229E" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXC4</accession>
    <name>A0A096NXC4_PAPAN</name>
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        <submittedName>
            <fullName evidence="4">NYN domain and retroviral integrase containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NYNRIN</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003901656.5"/>
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        <property type="protein sequence ID" value="ENSPANP00000017718.2"/>
        <property type="gene ID" value="ENSPANG00000018562.3"/>
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    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_235862_0_0_1"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Bgee" id="ENSPANG00000018562">
        <property type="expression patterns" value="Expressed in iris and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1298"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYG5</accession>
    <name>A0A096NYG5_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">IQ motif containing F3</fullName>
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        <name evidence="1" type="primary">IQCF3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009198913.2">
        <property type="nucleotide sequence ID" value="XM_009200649.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYG5"/>
    <dbReference type="Ensembl" id="ENSPANT00000026827.3">
        <property type="protein sequence ID" value="ENSPANP00000018128.2"/>
        <property type="gene ID" value="ENSPANG00000022147.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023814"/>
    <dbReference type="KEGG" id="panu:101023814"/>
    <dbReference type="CTD" id="401067"/>
    <dbReference type="eggNOG" id="ENOG502T3TE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004641"/>
    <dbReference type="HOGENOM" id="CLU_114989_2_0_1"/>
    <dbReference type="OMA" id="WQCHRRY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022147">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039887">
        <property type="entry name" value="IQCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21633:SF5">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21633">
        <property type="entry name" value="IQ MOTIF CONTAINING F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018128.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="154" mass="18299" checksum="9121E73F4F86A8DA" modified="2022-05-25" version="2">MGSKCCKGGPDEDAVERQRKRKLLVAQLHHRKRVKAAGKIQAWWRGVLVRRILLVAALRAWMIQCWWRTLVQRRIHQRQQALLRVYVIQEQAVVKLQSCIRMWQCRQCYRQMCNSLRLFQVPESSLAFQTDSFLQVQYAIPSKQPEFHIEILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZI3</accession>
    <name>A0A096NZI3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 184 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAM184B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017814097.1">
        <property type="nucleotide sequence ID" value="XM_017958608.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZI3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018504"/>
    <dbReference type="Ensembl" id="ENSPANT00000011847.3">
        <property type="protein sequence ID" value="ENSPANP00000018504.1"/>
        <property type="gene ID" value="ENSPANG00000011425.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998143"/>
    <dbReference type="KEGG" id="panu:100998143"/>
    <dbReference type="CTD" id="27146"/>
    <dbReference type="eggNOG" id="ENOG502RRRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063669"/>
    <dbReference type="HOGENOM" id="CLU_005374_0_0_1"/>
    <dbReference type="OMA" id="PQELDCQ"/>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011425">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF8">
        <property type="entry name" value="PROTEIN FAM184B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="405"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="813"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121321" checksum="57D37D277D7209B8" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZM3</accession>
    <name>A0A096NZM3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Centaurin-delta-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ARAP2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NZM3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018544"/>
    <dbReference type="Ensembl" id="ENSPANT00000008590.3">
        <property type="protein sequence ID" value="ENSPANP00000018544.3"/>
        <property type="gene ID" value="ENSPANG00000021175.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160197"/>
    <dbReference type="HOGENOM" id="CLU_002900_0_1_1"/>
    <dbReference type="OMA" id="FAHSCET"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021175">
        <property type="expression patterns" value="Expressed in thymus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08856">
        <property type="entry name" value="ArfGap_ARAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13253">
        <property type="entry name" value="PH1_ARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13254">
        <property type="entry name" value="PH2_ARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13256">
        <property type="entry name" value="PH3_ARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13257">
        <property type="entry name" value="PH4_ARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13259">
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    </dbReference>
    <dbReference type="CDD" id="cd17227">
        <property type="entry name" value="RA_ARAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04385">
        <property type="entry name" value="RhoGAP_ARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09490">
        <property type="entry name" value="SAM_Arap1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000128">
        <property type="entry name" value="arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2"/>
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    <dbReference type="FunFam" id="2.30.29.30:FF:000224">
        <property type="entry name" value="arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2"/>
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    <dbReference type="FunFam" id="2.30.29.30:FF:000316">
        <property type="entry name" value="Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2"/>
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    <dbReference type="FunFam" id="2.30.29.30:FF:000340">
        <property type="entry name" value="Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2"/>
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    <dbReference type="FunFam" id="1.10.220.150:FF:000006">
        <property type="entry name" value="arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3"/>
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    <dbReference type="FunFam" id="1.10.555.10:FF:000019">
        <property type="entry name" value="Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3"/>
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    <dbReference type="FunFam" id="1.10.150.50:FF:000070">
        <property type="entry name" value="ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2"/>
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    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
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    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
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    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
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    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
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    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
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    <dbReference type="InterPro" id="IPR037858">
        <property type="entry name" value="RhoGAP_ARAP"/>
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    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
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    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
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    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
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    <dbReference type="Pfam" id="PF01412">
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        <property type="entry name" value="SAM_1"/>
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        <property type="entry name" value="REVINTRACTNG"/>
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        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
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        <property type="entry name" value="SAM/Pointed domain"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
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        <location>
            <begin position="485"/>
            <end position="577"/>
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    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="590"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="16">
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            <end position="814"/>
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        <location>
            <begin position="881"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="18">
        <location>
            <begin position="1119"/>
            <end position="1300"/>
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    <feature type="domain" description="Ras-associating" evidence="17">
        <location>
            <begin position="1329"/>
            <end position="1423"/>
        </location>
    </feature>
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        <location>
            <begin position="1437"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1641"/>
            <end position="1677"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1661"/>
            <end position="1677"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057622"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073336"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018544.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1707" mass="193768" checksum="2FFE987D1B284AC6" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1D9</accession>
    <name>A0A096P1D9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Antiviral innate immune response receptor RIG-I</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">ATP-dependent RNA helicase DDX58</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">DEAD box protein 58</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">RIG-I-like receptor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="34">RNA sensor RIG-I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">Retinoic acid-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Retinoic acid-inducible gene I protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">RIGI</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="40" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A096P1D9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019164"/>
    <dbReference type="Ensembl" id="ENSPANT00000026031.3">
        <property type="protein sequence ID" value="ENSPANP00000019164.2"/>
        <property type="gene ID" value="ENSPANG00000025269.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997060"/>
    <dbReference type="KEGG" id="panu:100997060"/>
    <dbReference type="CTD" id="23586"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153173"/>
    <dbReference type="OMA" id="FFANHVP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025269">
        <property type="expression patterns" value="Expressed in pancreas and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038187">
        <property type="term" value="F:pattern recognition receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071360">
        <property type="term" value="P:cellular response to exogenous dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009597">
        <property type="term" value="P:detection of virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032725">
        <property type="term" value="P:positive regulation of granulocyte macrophage colony-stimulating factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032757">
        <property type="term" value="P:positive regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002735">
        <property type="term" value="P:positive regulation of myeloid dendritic cell cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060760">
        <property type="term" value="P:positive regulation of response to cytokine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039529">
        <property type="term" value="P:RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08817">
        <property type="entry name" value="CARD_RIG-I_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18073">
        <property type="entry name" value="DEXHc_RIG-I_DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12090">
        <property type="entry name" value="MDA5_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15805">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000072">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000078">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1320.30:FF:000002">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.30:FF:000001">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001233">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001291">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042145">
        <property type="entry name" value="CARD_RIG-I_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0007">Acetylation</keyword>
    <keyword evidence="24" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="27" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0347">Helicase</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="25" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 36" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="21" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="17 36" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="37">
        <location>
            <begin position="251"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="38">
        <location>
            <begin position="610"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="39">
        <location>
            <begin position="794"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="binding site" evidence="36">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="36">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="36">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="36">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00072152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00075180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00075549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00077844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00078832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00081416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00081900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019164.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="925" mass="106517" checksum="D3854AEF67FD7D5D" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2B3</accession>
    <name>A0A096P2B3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912118.1">
        <property type="nucleotide sequence ID" value="XM_003912069.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2B3"/>
    <dbReference type="Ensembl" id="ENSPANT00000024195.4">
        <property type="protein sequence ID" value="ENSPANP00000019488.2"/>
        <property type="gene ID" value="ENSPANG00000024592.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101017924"/>
    <dbReference type="KEGG" id="panu:101017924"/>
    <dbReference type="CTD" id="6117"/>
    <dbReference type="eggNOG" id="KOG0851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012403"/>
    <dbReference type="OMA" id="DQCDAFY"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024592">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P2B3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4P7</accession>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Awwad R.A."/>
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                <person name="Bandaranaike D.B."/>
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                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Chau D.C."/>
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                <person name="Usmani K.U."/>
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                <person name="Zhu Y.Z."/>
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                <person name="Worley K.W."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912898.1">
        <property type="nucleotide sequence ID" value="XM_003912849.5"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000020406"/>
    <dbReference type="Ensembl" id="ENSPANT00000002502.3">
        <property type="protein sequence ID" value="ENSPANP00000020406.2"/>
        <property type="gene ID" value="ENSPANG00000022177.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998363"/>
    <dbReference type="KEGG" id="panu:100998363"/>
    <dbReference type="CTD" id="9969"/>
    <dbReference type="eggNOG" id="KOG3600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013680"/>
    <dbReference type="HOGENOM" id="CLU_000508_0_0_1"/>
    <dbReference type="OMA" id="WWGEDPS"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022177">
        <property type="expression patterns" value="Expressed in esophagus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046966">
        <property type="term" value="F:nuclear thyroid hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MID" evidence="11">
        <location>
            <begin position="1367"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="10">
        <location>
            <begin position="1760"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="709"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="788"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1484"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1557"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2016"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1484"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1563"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1580"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1595"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020406.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2174" mass="239379" checksum="597F2E5ADC490DF7" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5A6</accession>
    <name>A0A096P5A6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SH3 and cysteine-rich domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">24b2/STAC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Src homology 3 and cysteine-rich domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">STAC2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domains) with CACNA1S. Interacts (via SH3 domains) with CACNA1C. Has much lower affinity for CACNA1C than for CACNA1S.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003912969.1">
        <property type="nucleotide sequence ID" value="XM_003912920.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P5A6"/>
    <dbReference type="SMR" id="A0A096P5A6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020531"/>
    <dbReference type="Ensembl" id="ENSPANT00000004101.3">
        <property type="protein sequence ID" value="ENSPANP00000020531.2"/>
        <property type="gene ID" value="ENSPANG00000021976.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999655"/>
    <dbReference type="KEGG" id="panu:100999655"/>
    <dbReference type="CTD" id="342667"/>
    <dbReference type="eggNOG" id="ENOG502QW9G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183092"/>
    <dbReference type="HOGENOM" id="CLU_048120_2_0_1"/>
    <dbReference type="OMA" id="QQACNGK"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021976">
        <property type="expression patterns" value="Expressed in prefrontal cortex and 36 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20881">
        <property type="entry name" value="C1_Stac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11985">
        <property type="entry name" value="SH3_Stac2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000073">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000022">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035509">
        <property type="entry name" value="Stac2_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF5">
        <property type="entry name" value="SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16664">
        <property type="entry name" value="STAC2_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="220"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="411" mass="44873" checksum="57D6BF6DC8777C6C" modified="2018-02-28" version="2">MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSVENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLPTPSPSPCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKTCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPACATSKESPPTGASGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQPPKAALRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5B5</accession>
    <name>A0A096P5B5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031508067.1">
        <property type="nucleotide sequence ID" value="XM_031652207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P5B5"/>
    <dbReference type="Ensembl" id="ENSPANT00000004110.3">
        <property type="protein sequence ID" value="ENSPANP00000020540.3"/>
        <property type="gene ID" value="ENSPANG00000021898.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018358"/>
    <dbReference type="eggNOG" id="ENOG502QUZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016052"/>
    <dbReference type="HOGENOM" id="CLU_117454_0_0_1"/>
    <dbReference type="OMA" id="DITNCES"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021898">
        <property type="expression patterns" value="Expressed in renal medulla and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P5B5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040174">
        <property type="entry name" value="RNLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23357">
        <property type="entry name" value="RENALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23357:SF1">
        <property type="entry name" value="RENALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020540.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="175" mass="19370" checksum="6A4707483318DD7D" modified="2022-05-25" version="3">MARVLIVGAGVTGSLCAALLRRQTSRPLYLAVWDKAEDSGGRMTTASSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAHGILRPLTSPIEGMVMKAGDCNFVAPQGISSIIKHYLKESGAEVYFRHHVTQINLRNDKWEVSKQTGPPEQFDLIVLTMPVPQILQLQGDITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P614</accession>
    <name>A0A096P614_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
            <ecNumber evidence="5">4.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dihydrodipicolinate synthase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Probable 2-keto-4-hydroxyglutarate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HOGA1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the final step in the metabolic pathway of hydroxyproline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.16" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003904131.1">
        <property type="nucleotide sequence ID" value="XM_003904082.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P614"/>
    <dbReference type="Ensembl" id="ENSPANT00000014197.3">
        <property type="protein sequence ID" value="ENSPANP00000020789.1"/>
        <property type="gene ID" value="ENSPANG00000040105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101014787"/>
    <dbReference type="KEGG" id="panu:101014787"/>
    <dbReference type="CTD" id="112817"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063604"/>
    <dbReference type="HOGENOM" id="CLU_049343_0_1_1"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021292">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P614">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:(R,S)-4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042866">
        <property type="term" value="P:pyruvate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019470">
        <property type="term" value="P:trans-4-hydroxy-L-proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000153">
        <property type="entry name" value="4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="16">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="327" mass="35306" checksum="58B1099B5C17D48E" modified="2014-11-26" version="1">MLGPQVWSSVRQGLSRSLSRNVRGWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNKLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCLTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKMMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUE9</accession>
    <name>A0A0A0MUE9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial coenzyme A transporter SLC25A42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 25 member 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC25A42</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72843"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ADP(out) + CoA(in) = ADP(in) + CoA(out)</text>
            <dbReference type="Rhea" id="RHEA:72839"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>AMP(in) + ADP(out) = AMP(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72851"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72847"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dADP(in) + ADP(out) = dADP(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72855"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915261.1">
        <property type="nucleotide sequence ID" value="XM_003915212.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009192193.1">
        <property type="nucleotide sequence ID" value="XM_009193929.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUE9"/>
    <dbReference type="SMR" id="A0A0A0MUE9"/>
    <dbReference type="Ensembl" id="ENSPANT00000011427.3">
        <property type="protein sequence ID" value="ENSPANP00000001351.1"/>
        <property type="gene ID" value="ENSPANG00000004441.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026542"/>
    <dbReference type="KEGG" id="panu:101026542"/>
    <dbReference type="CTD" id="284439"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158163"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_1_1"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004441">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MUE9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043262">
        <property type="term" value="F:ADP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000014">
        <property type="entry name" value="mitochondrial coenzyme A transporter SLC25A42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="318" mass="35433" checksum="37EAC195DCED0914" modified="2015-01-07" version="1">MDNGVKEGPVRLREDAEAVLSSSVSSKRDHRQVLSSLLSGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVTGYPRASIACTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDLMQILLRHLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUJ9</accession>
    <name>A0A0A0MUJ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger and SCAN domain containing 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZSCAN18</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUJ9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001778"/>
    <dbReference type="Ensembl" id="ENSPANT00000014338.3">
        <property type="protein sequence ID" value="ENSPANP00000001778.3"/>
        <property type="gene ID" value="ENSPANG00000012093.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163034"/>
    <dbReference type="HOGENOM" id="CLU_002678_49_8_1"/>
    <dbReference type="OMA" id="CPESCKK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012093">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF32">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN CONTAINING 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239831" evidence="4">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="SCAN box" evidence="5">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001778.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="374" mass="41175" checksum="F0059CEC7A11D98A" modified="2022-05-25" version="3">MVSLFSGSWGGCALALCKAIVLSVSSAGLWVLAPSEPPGNPWHLCFGATLSPVRQCRIFQCRFGKMLPLEKAFASPRSSPTPLDLPTPGSAAGAQQEEPETIPERTPADLEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLVEGLADVLDEPGMLLGSPAGSSSILSDGVYERHMDPLLLPGEFESPSQAPGAGEIPAPSETPWLSPDSLFLEQRRVREARTEEASPANTEQKLKSFPEEPQHMEEWGHLDPAEENLKSYRKLLLWGYQLSQPDAASRLDTEELRLVERDSQGSGLPEGGRRQETAGCACEEAAPARGVPELMRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUM8</accession>
    <name>A0A0A0MUM8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytohesin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">PH, SEC7 and coiled-coil domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CYTH2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUM8"/>
    <dbReference type="SMR" id="A0A0A0MUM8"/>
    <dbReference type="Ensembl" id="ENSPANT00000018006.3">
        <property type="protein sequence ID" value="ENSPANP00000002293.2"/>
        <property type="gene ID" value="ENSPANG00000009361.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160074"/>
    <dbReference type="HOGENOM" id="CLU_032820_3_0_1"/>
    <dbReference type="OMA" id="GASHWRA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009361">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MUM8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000003">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000009">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF343">
        <property type="entry name" value="CYTOHESIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="15">
        <location>
            <begin position="54"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="259"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002293.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="400" mass="46546" checksum="70441A58483BD0E1" modified="2018-02-28" version="2">MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MV17</accession>
    <name>A0A0A0MV17_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POLR2I</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915438.1">
        <property type="nucleotide sequence ID" value="XM_003915389.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MV17"/>
    <dbReference type="SMR" id="A0A0A0MV17"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004770"/>
    <dbReference type="Ensembl" id="ENSPANT00000025476.3">
        <property type="protein sequence ID" value="ENSPANP00000004770.1"/>
        <property type="gene ID" value="ENSPANG00000004508.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021248"/>
    <dbReference type="KEGG" id="panu:101021248"/>
    <dbReference type="CTD" id="5438"/>
    <dbReference type="eggNOG" id="KOG2691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075063"/>
    <dbReference type="HOGENOM" id="CLU_093932_0_1_1"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004508">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
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        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
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        <property type="entry name" value="Zn_ribbon_RPB9"/>
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    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
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    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
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        <property type="entry name" value="Zn_ribbon_TFIIS"/>
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        <property type="entry name" value="RNApol_RpoM"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZnF_C2C2"/>
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        <property type="entry name" value="Zinc beta-ribbon"/>
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        <property type="entry name" value="RNA_POL_M_15KD"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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            <position position="20"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="125" mass="14523" checksum="6520687BB57EE018" modified="2015-01-07" version="1">MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LPX5</accession>
    <name>A0A2I3LPX5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ribosyldihydronicotinamide dehydrogenase [quinone]</fullName>
            <ecNumber evidence="15">1.10.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">NRH dehydrogenase [quinone] 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NRH:quinone oxidoreductase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Quinone reductase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NQO2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol</text>
            <dbReference type="Rhea" id="RHEA:12364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15927"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:55458"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.10.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="EC" id="1.10.5.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003897007.1">
        <property type="nucleotide sequence ID" value="XM_003896958.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202627.1">
        <property type="nucleotide sequence ID" value="XM_009204363.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LPX5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000025523"/>
    <dbReference type="Ensembl" id="ENSPANT00000040895.2">
        <property type="protein sequence ID" value="ENSPANP00000025523.1"/>
        <property type="gene ID" value="ENSPANG00000033064.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101010086"/>
    <dbReference type="KEGG" id="panu:101010086"/>
    <dbReference type="CTD" id="4835"/>
    <dbReference type="GeneTree" id="ENSGT00940000156563"/>
    <dbReference type="OMA" id="GREHMFG"/>
    <dbReference type="OrthoDB" id="26889at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033064">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001512">
        <property type="term" value="F:dihydronicotinamide riboside quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000030">
        <property type="entry name" value="ribosyldihydronicotinamide dehydrogenase [quinone]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF33">
        <property type="entry name" value="RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="20">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="231" mass="26136" checksum="DB83ABDC45244DC5" modified="2018-02-28" version="1">MAGKKVLIVYAHEEPRSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATRKDITAALSNPEVFNYGVETYEAYKQKSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCRGFAFDIPGFYDSGLLQGKLGLLSVTTGGTAEMYTKTGVNGDFRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKEMVAAWSQRLQTIWKEKPIPCTAPWYFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M1D6</accession>
    <name>A0A2I3M1D6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NAD(P)H dehydrogenase [quinone] 1</fullName>
            <ecNumber evidence="4">1.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Azoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DT-diaphorase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Menadione reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">NAD(P)H:quinone oxidoreductase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Phylloquinone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Quinone reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">NQO1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46161"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a quinone + NADPH + H(+) = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:46165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>menadione + NADH + H(+) = menadiol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:69695"/>
            <dbReference type="ChEBI" id="CHEBI:6746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28869"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:69696"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ubiquinone-10 + NADH + H(+) = ubiquinol-10 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:61984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:61985"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer. Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome. Interacts with TP73 (via SAM domain); this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome. Interacts with TP53; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3M1D6"/>
    <dbReference type="Ensembl" id="ENSPANT00000050101.2">
        <property type="protein sequence ID" value="ENSPANP00000029517.2"/>
        <property type="gene ID" value="ENSPANG00000032471.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159150"/>
    <dbReference type="OMA" id="HGILHYP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032471">
        <property type="expression patterns" value="Expressed in thyroid gland and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110076">
        <property type="term" value="P:negative regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061771">
        <property type="term" value="P:response to caloric restriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006743">
        <property type="term" value="P:ubiquinone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042360">
        <property type="term" value="P:vitamin E metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000029">
        <property type="entry name" value="NAD(P)H dehydrogenase [quinone] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF1">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="26">
        <location>
            <begin position="4"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029517.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="273" mass="30685" checksum="34CE777425E0BBFC" modified="2022-05-25" version="2">MVGKRALIVLAHSERTSFNYAMKEAAVAALKKKGWEVAESDLYAMNFNPIISRKDITGKLKDPANFQYADESILAYKEGRLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFVGEFAYTAAMYDKGPFQSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7R0</accession>
    <name>A0A2I3M7R0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP binding cassette subfamily C member 4 (PEL blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABCC4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19121"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19122"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031511460.1">
        <property type="nucleotide sequence ID" value="XM_031655600.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPANP00000031698.2"/>
        <property type="gene ID" value="ENSPANG00000026361.3"/>
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        <property type="component" value="Chromosome 15"/>
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    <dbReference type="Bgee" id="ENSPANG00000026361">
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
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        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="106"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="173"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="267"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="298"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="636"/>
            <end position="655"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="692"/>
            <end position="716"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="785"/>
            <end position="807"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="873"/>
            <end position="895"/>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="104"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="335"/>
            <end position="558"/>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="640"/>
            <end position="930"/>
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    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="966"/>
            <end position="1199"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="582"/>
            <end position="608"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="582"/>
            <end position="592"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047576"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048007"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031698.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1250" mass="140742" checksum="463F56774073BAF6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MKV5</accession>
    <name>A0A2I3MKV5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuron navigator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NAV2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000039603.2">
        <property type="protein sequence ID" value="ENSPANP00000036403.2"/>
        <property type="gene ID" value="ENSPANG00000017038.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155663"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017038">
        <property type="expression patterns" value="Expressed in aorta and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MKV5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21285">
        <property type="entry name" value="CH_NAV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000018">
        <property type="entry name" value="Neuron navigator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000451">
        <property type="entry name" value="Neuron navigator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="NEURON NAVIGATOR 2"/>
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        <property type="entry name" value="AAA_lid_NAV1"/>
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        <property type="entry name" value="Ubiquitin_6"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MRI1</accession>
    <name>A0A2I3MRI1_PAPAN</name>
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        <recommendedName>
            <fullName evidence="5 16">CD40 ligand</fullName>
            <shortName evidence="16">CD40-L</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">Tumor necrosis factor ligand superfamily member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CD40LG</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.</text>
    </comment>
    <comment type="function">
        <molecule>CD40 ligand, soluble form</molecule>
        <text evidence="16">Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the tumor necrosis factor family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000038354.1"/>
        <property type="gene ID" value="ENSPANG00000033140.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278318"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033140">
        <property type="expression patterns" value="Expressed in axillary lymph node and 37 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005174">
        <property type="term" value="F:CD40 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00184">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CD40 ligand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003263">
        <property type="entry name" value="CD40L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021184">
        <property type="entry name" value="TNF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF5">
        <property type="entry name" value="CD40 LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016527">
        <property type="entry name" value="TNF_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01702">
        <property type="entry name" value="CD40LIGAND"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00251">
        <property type="entry name" value="THD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 16" id="KW-0202">Cytokine</keyword>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="20">
        <location>
            <begin position="94"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage" evidence="17">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR016527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR016527-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="240" mass="27242" checksum="D61CFA0C1D2EB2AC" modified="2018-02-28" version="1">MIETYNQPSPRSAATGLPVRMKIFMYLLTIFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEEKKKENSFEMQKVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUE5</accession>
    <name>A0A2I3MUE5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUE5"/>
    <dbReference type="Ensembl" id="ENSPANT00000034996.2">
        <property type="protein sequence ID" value="ENSPANP00000039347.2"/>
        <property type="gene ID" value="ENSPANG00000000877.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162212"/>
    <dbReference type="OMA" id="NPEVEWQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000877">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MUE5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004865">
        <property type="entry name" value="HSR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043563">
        <property type="entry name" value="Sp110/Sp140/Sp140L-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46386:SF12">
        <property type="entry name" value="NUCLEAR AUTOANTIGEN SP-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46386">
        <property type="entry name" value="NUCLEAR BODY PROTEIN SP140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03172">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51414">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039347.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="442" mass="49769" checksum="544791EB74E86E6E" modified="2022-05-25" version="2">MVSFFPRMFTEDQDVDEGLLCDAVFKHFKRHKVEISNAIKKTFPFLEGLRDRELITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKMFSLPVLEALFSEVNLQEYPDLIHIYESFKNVIQDKLPLRESDGEEREERPGIQLSLEQGTGENSFQSLTWPRWDSPSHDGTTPPENGLSEHPCETAEINADRKDTTSDKNGSLGSQQTNEQSAQKTEPTESCEQVAVQVSNGDAGRETPCPLPCDEEGAEPLNHGIQINSCSVRLVDIKKEKPYCTSNAECQAQASDIIVISSEDSEGSTDVDEPLEVFISPVRSKPVINNDNSLESNEEKEGQEATCSRPQTVPEPMDSRKSSIFRERFRKRVIGQDCNFSDSSEEETLPEVLRRALRSKHGEKDPVTSRSTSTWGIPNRKRRFSSSDFSELSNGEELQETCSSSLRRGSGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MVL3</accession>
    <accession>A0A096MTK1</accession>
    <name>A0A2I3MVL3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Follistatin-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Follistatin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FSTL1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with SCN10A. Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1. Interacts with BMP4. Interacts with CD14; this interaction promotes TL4-mediated signaling cascade.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003894029.1">
        <property type="nucleotide sequence ID" value="XM_003893980.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MVL3"/>
    <dbReference type="SMR" id="A0A2I3MVL3"/>
    <dbReference type="Ensembl" id="ENSPANT00000057487.2">
        <property type="protein sequence ID" value="ENSPANP00000039646.2"/>
        <property type="gene ID" value="ENSPANG00000011991.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025921"/>
    <dbReference type="KEGG" id="panu:101025921"/>
    <dbReference type="CTD" id="11167"/>
    <dbReference type="GeneTree" id="ENSGT00940000157784"/>
    <dbReference type="OMA" id="CIERCKP"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011991">
        <property type="expression patterns" value="Expressed in urinary bladder and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MVL3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061484">
        <property type="term" value="P:hematopoietic stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16233">
        <property type="entry name" value="EFh_SPARC_FSTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000017">
        <property type="entry name" value="Follistatin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057020">
        <property type="entry name" value="EF-hand_FSTL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015369">
        <property type="entry name" value="Follistatin/Osteonectin_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF13">
        <property type="entry name" value="FOLLISTATIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF23564">
        <property type="entry name" value="EF-hand_FSTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09289">
        <property type="entry name" value="FOLN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF23244">
        <property type="entry name" value="VWF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035254282" description="Follistatin-related protein 1" evidence="14">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="16">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019697"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00042478"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00045812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039646.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="308" mass="34986" checksum="BD4C651FAFF24800" modified="2022-05-25" version="2">MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N376</accession>
    <name>A0A2I3N376_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Serine/threonine-protein kinase/endoribonuclease IRE1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Endoplasmic reticulum-to-nucleus signaling 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Inositol-requiring protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Ire1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">ERN1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <property type="term" value="P:positive regulation of JNK cascade"/>
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            <begin position="835"/>
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            <begin position="491"/>
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            <begin position="410"/>
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            <begin position="513"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00078578"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00083182"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042458.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="977" mass="109835" checksum="D8144AE27EBCEDA6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N730</accession>
    <name>A0A2I3N730_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Arachidonate--CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.15</ecNumber>
            <ecNumber evidence="15">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">SLC27A4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)</text>
            <dbReference type="Rhea" id="RHEA:33655"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)</text>
            <dbReference type="Rhea" id="RHEA:45264"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a fatty acid(in) = a fatty acid(out)</text>
            <dbReference type="Rhea" id="RHEA:38879"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoate(out) = hexadecanoate(in)</text>
            <dbReference type="Rhea" id="RHEA:45256"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="14"/>
    <dbReference type="EC" id="6.2.1.3" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003911284.1">
        <property type="nucleotide sequence ID" value="XM_003911235.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186363.1">
        <property type="nucleotide sequence ID" value="XM_009188099.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186364.1">
        <property type="nucleotide sequence ID" value="XM_009188100.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017805045.1">
        <property type="nucleotide sequence ID" value="XM_017949556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N730"/>
    <dbReference type="STRING" id="9555.ENSPANP00000043672"/>
    <dbReference type="Ensembl" id="ENSPANT00000048073.2">
        <property type="protein sequence ID" value="ENSPANP00000043672.2"/>
        <property type="gene ID" value="ENSPANG00000025877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002894"/>
    <dbReference type="KEGG" id="panu:101002894"/>
    <dbReference type="CTD" id="10999"/>
    <dbReference type="GeneTree" id="ENSGT00940000158646"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025877">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N730">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090434">
        <property type="term" value="F:oleoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990379">
        <property type="term" value="P:lipid transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001579">
        <property type="term" value="P:medium-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05939">
        <property type="entry name" value="hsFATP4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000008">
        <property type="entry name" value="Long-chain fatty acid transport protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF11">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="24">
        <location>
            <begin position="81"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="25">
        <location>
            <begin position="520"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036233"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036271"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043672.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="643" mass="72236" checksum="A7FF5B8DDF5BD70B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N9W9</accession>
    <name>A0A2I3N9W9_PAPAN</name>
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        <recommendedName>
            <fullName evidence="14">Adhesion G-protein coupled receptor G2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">G-protein coupled receptor 64</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADGRG2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with CFTR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_009197284.2"/>
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        <property type="protein sequence ID" value="ENSPANP00000044813.2"/>
        <property type="gene ID" value="ENSPANG00000004239.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019994"/>
    <dbReference type="KEGG" id="panu:101019994"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156341"/>
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        <property type="component" value="Chromosome X"/>
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    <dbReference type="Bgee" id="ENSPANG00000004239">
        <property type="expression patterns" value="Expressed in Ammon's horn and 49 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N9W9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:spermatid development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="GPS"/>
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        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="321"/>
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        <source>
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    <sequence length="1017" mass="111617" checksum="BE359B93B7AC24E9" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NA17</accession>
    <name>A0A2I3NA17_PAPAN</name>
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        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein acetyltransferase BLOC1S1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BLOC1S1</name>
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    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3NA17"/>
    <dbReference type="Ensembl" id="ENSPANT00000035064.2">
        <property type="protein sequence ID" value="ENSPANP00000044834.2"/>
        <property type="gene ID" value="ENSPANG00000044608.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002689"/>
    <dbReference type="OMA" id="THAMNSA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004852">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NA17">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044834.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="210" mass="23662" checksum="1AA2A2188350944B" modified="2022-05-25" version="2">MSIKKYFFQHSPKSKLPIKKTVHLPSATLYLPSPPRSSPNVSIEGGSQPHVTQWSRDMAPGSRGERSSFRSRRGPGVPSPQPDVTMLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NAI9</accession>
    <name>A0A2I3NAI9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Diacylglycerol kinase</fullName>
            <shortName evidence="21">DAG kinase</shortName>
            <ecNumber evidence="21">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DGKD</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="20">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="21"/>
    <dbReference type="RefSeq" id="XP_031507477.1">
        <property type="nucleotide sequence ID" value="XM_031651617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NAI9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000045049"/>
    <dbReference type="Ensembl" id="ENSPANT00000052688.2">
        <property type="protein sequence ID" value="ENSPANP00000045049.1"/>
        <property type="gene ID" value="ENSPANG00000017057.3"/>
    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135005" checksum="D924FF3270327D5B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NFZ6</accession>
    <name>A0A2I3NFZ6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear RNA activating complex polypeptide 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SNAPC2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003919438.2">
        <property type="nucleotide sequence ID" value="XM_003919389.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I3NFZ6"/>
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        <property type="protein sequence ID" value="ENSPANP00000046835.2"/>
        <property type="gene ID" value="ENSPANG00000025882.3"/>
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    <dbReference type="GeneID" id="101011111"/>
    <dbReference type="KEGG" id="panu:101011111"/>
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    <dbReference type="GeneTree" id="ENSGT00390000017407"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:nuclear body"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15132:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
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    <dbReference type="Pfam" id="PF11035">
        <property type="entry name" value="SNAPC2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="263"/>
            <end position="303"/>
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    </feature>
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        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046835.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="333" mass="35346" checksum="663D031820BF3B36" modified="2022-05-25" version="2">MKPPPRRRAAPARYLGEVTGPTTWSAREKRQLVRLLQARQGQPEPDAAELARELQGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDSAPEIPSSAPKAPSSTPDTSDPAPEKPASSAGPSTEEDFAVDFEKIYKYLSSLSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPSPAGGSLGPAAEGDGAGSKAPEETPPATKKAEPSELKSSWQAAGICPLNPFLVPLELLGRAATPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MVP5</accession>
    <name>A0A8I5MVP5_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1196" mass="139116" checksum="64D1979ABDCD889C" modified="2022-05-25" version="1"> </sequence>
</entry>
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                <consortium name="Ensembl"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR40389">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389:SF2">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02337">
        <property type="entry name" value="Gag_p10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00607">
        <property type="entry name" value="Gag_p24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="Retroviral matrix proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-retroviral matrix protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="398" mass="45179" checksum="699A80D1EE01E040" modified="2022-05-25" version="1">MGQTKSKYASYRSFVKILLKRGGVKVSTKNLIMQFQTIEQFCPWFPEQGTLDLKDWEKIGKELKQASREGKIIPLTVWNDWVIIKVVLEPFQTEEDNIPISDVPKSCAVDCEKEAGIESQKGKESSHCKCVSELVMARSMQSVDDNQLQEVVYPETLKLEETDPELAEPSESKPRWPTALPAAQMPVTLQPQMQVKQVLTPKEDQIEKDRASVMAMPIQIQCLQYQPVENKTQQPVVYQYWPPAELQYRQPPENPYGQPGMFPVPQGRVPYQPPTMRLNPTAPPSTHGSALHKIIDEARKKGDIEAWQFPVILEARPPGEGAQEGELPVAEARYKSFSIKMLKEMKEGVKQYGSNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSPFQVLQFRSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXT4</accession>
    <name>A0A8I5MXT4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXT4"/>
    <dbReference type="Ensembl" id="ENSPANT00000071770.1">
        <property type="protein sequence ID" value="ENSPANP00000049550.1"/>
        <property type="gene ID" value="ENSPANG00000043388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="11990" checksum="1504891DA39649D5" modified="2022-05-25" version="1">MILAHCSLYLPGSSDSPASASRVAGIIVTCHQAWLIFFFFFFFFFFETESHSLTQAGVQWCSSLQAPSPGFMPFSRVSLPSNWDYRRLPPRPANFLYLLLETVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MYA9</accession>
    <name>A0A8I5MYA9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MYA9"/>
    <dbReference type="Ensembl" id="ENSPANT00000077098.1">
        <property type="protein sequence ID" value="ENSPANP00000049874.1"/>
        <property type="gene ID" value="ENSPANG00000043778.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="OMA" id="FCISVET"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF12">
        <property type="entry name" value="RNA BINDING MOTIF SINGLE STRANDED INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="74" mass="8493" checksum="F0E14CC3FF8BCBF7" modified="2022-05-25" version="1">MYVYVCLSLYFEMESRSITQAGVQWHDLGSPQPLPSGFKRFSCLSLLSSWDYRHPPPCLVSFVFFVETGFLHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MYN1</accession>
    <name>A0A8I5MYN1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RASL11A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003913747.2">
        <property type="nucleotide sequence ID" value="XM_003913698.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MYN1"/>
    <dbReference type="Ensembl" id="ENSPANT00000081820.1">
        <property type="protein sequence ID" value="ENSPANP00000050114.1"/>
        <property type="gene ID" value="ENSPANG00000044196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100998253"/>
    <dbReference type="KEGG" id="panu:100998253"/>
    <dbReference type="CTD" id="387496"/>
    <dbReference type="GeneTree" id="ENSGT00940000161208"/>
    <dbReference type="OMA" id="TMSGHCL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04146">
        <property type="entry name" value="RERG_RasL11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000718">
        <property type="entry name" value="Ras-like protein family member 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="242" mass="27036" checksum="BD6C958E0D44F817" modified="2022-05-25" version="1">MRPLSMSGHFLLSPIPESSSDYLLPKDIKLAVLGAGRVGKSAMIVRFLTKRFIGDYEPNTGKLYSRLVYVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQTQDGIQLANELGSLFLEISTSENYEDVCDVFQHLCKEVSKMHGLSGERRRASIIPRPRSPNMQDLKRRFKQALSPKVKAPTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1W2</accession>
    <name>A0A8I5N1W2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N1W2"/>
    <dbReference type="Ensembl" id="ENSPANT00000078173.1">
        <property type="protein sequence ID" value="ENSPANP00000052180.1"/>
        <property type="gene ID" value="ENSPANG00000038859.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160803"/>
    <dbReference type="OMA" id="TTERWGH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000006">
        <property type="entry name" value="Pleckstrin homology like domain family B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF22">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="310" mass="34368" checksum="F95B47815A5880D1" modified="2022-05-25" version="1">MAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDHQLLVLQDPAAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERASQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAVHPDIAHMERLLQQAMAERERLLKAREGTRRGTEGSSGPAVPAITVSGGCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPSPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N4Q8</accession>
    <name>A0A8I5N4Q8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RAB5 interacting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB5IF</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009214436.1">
        <property type="nucleotide sequence ID" value="XM_009216172.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N4Q8"/>
    <dbReference type="SMR" id="A0A8I5N4Q8"/>
    <dbReference type="Ensembl" id="ENSPANT00000073583.1">
        <property type="protein sequence ID" value="ENSPANP00000048090.1"/>
        <property type="gene ID" value="ENSPANG00000021331.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103875485"/>
    <dbReference type="KEGG" id="panu:103875485"/>
    <dbReference type="CTD" id="55969"/>
    <dbReference type="GeneTree" id="ENSGT00390000004786"/>
    <dbReference type="OMA" id="ANSEWPD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="129" mass="14825" checksum="DA8C4AC79B9AFD22" modified="2022-05-25" version="1">MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWEDKDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N508</accession>
    <name>A0A8I5N508_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Golgi-associated PDZ and coiled-coil motif-containing protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CFTR-associated ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">PDZ protein interacting specifically with TC10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GOPC</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003898309.1">
        <property type="nucleotide sequence ID" value="XM_003898260.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N508"/>
    <dbReference type="Ensembl" id="ENSPANT00000076632.1">
        <property type="protein sequence ID" value="ENSPANP00000048270.1"/>
        <property type="gene ID" value="ENSPANG00000020085.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101010343"/>
    <dbReference type="CTD" id="57120"/>
    <dbReference type="GeneTree" id="ENSGT00940000156535"/>
    <dbReference type="OMA" id="QCNLRQE"/>
    <dbReference type="OrthoDB" id="10063653at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140313">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="bZIP"/>
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        <property type="entry name" value="PDZ_GOPC-like"/>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528:SF2">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="18">
        <location>
            <begin position="288"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="426"/>
            <end position="447"/>
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    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="84"/>
            <end position="118"/>
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    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00023018"/>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00083668"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="462" mass="50550" checksum="8471C3424A8B7FBC" modified="2022-05-25" version="1">MSAGGPCPAAAGGGPGGASCSAGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDSASKLDDLHTLYHKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N5X1</accession>
    <name>A0A8I5N5X1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="15">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SOD3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N5X1"/>
    <dbReference type="Ensembl" id="ENSPANT00000066679.1">
        <property type="protein sequence ID" value="ENSPANP00000051429.1"/>
        <property type="gene ID" value="ENSPANG00000044825.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162224"/>
    <dbReference type="OMA" id="DGSLWKY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000008">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10 15" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035216848" description="Superoxide dismutase [Cu-Zn]" evidence="16">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="17">
        <location>
            <begin position="60"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="222" mass="24067" checksum="3E8C0E4B37B23A3D" modified="2022-05-25" version="1">MLALLCSCLLLAAGASDAWTGEDSAEPNSDLAESIRDMHAKITEIWQELTQRLDAAQPRVTGVVLFRQLAPRAKLEAFFALEGFPTEPKNSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHPRHPGDFGNFAVRDGSLWKYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCRPGLWERQAREHSERKKRRRESECKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8T7</accession>
    <name>A0A8I5N8T7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8T7"/>
    <dbReference type="Ensembl" id="ENSPANT00000078087.1">
        <property type="protein sequence ID" value="ENSPANP00000057288.1"/>
        <property type="gene ID" value="ENSPANG00000037470.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000248305"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="150" mass="16526" checksum="4E10788E60E203F8" modified="2022-05-25" version="1">MKAQKKRKKTRNRASVANGGEKASEKPAPEEVPVSAEAQVQAVGPGIGLVRGATAAWSQEAETHPDTNEVSLRCQPGVRWCDLGSLQPPPARFKRFSCLNLPRSWTECVPHDPAYLCIFSSDGISPCWPGWSQSLDHVIWSPWLPKVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBQ8</accession>
    <name>A0A8I5NBQ8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBQ8"/>
    <dbReference type="Ensembl" id="ENSPANT00000071953.1">
        <property type="protein sequence ID" value="ENSPANP00000059264.1"/>
        <property type="gene ID" value="ENSPANG00000044122.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162994"/>
    <dbReference type="OMA" id="MAEACAN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045345">
        <property type="entry name" value="Gag_p24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050195">
        <property type="entry name" value="Primate_lentivir_Gag_pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008916">
        <property type="entry name" value="Retrov_capsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389:SF2">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00607">
        <property type="entry name" value="Gag_p24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19317">
        <property type="entry name" value="Gag_p24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="389" mass="42784" checksum="4E530E8A3B428127" modified="2022-05-25" version="1">MVQMWAVVHSTLELFHTDDEEEGECNEVTEEVTDQVYLPAKAKAAKEGEVHPYPSAPPHYYFEEKDPPDLSFLEDTGRKVVAPVAVRTAPRATAVISIQAGIQQARREGDLEAWQFPVRIHAPDQQGNIIATFESFPFKLLKKFEQAINQYGPGSPSVTGLLKNVAVSSRMIPSDWDALTRACLTPAQFLQFKTWWADEAPIQAARNAQAQPQINTTADQLLGVGGWAGLDAQLVMQDDAIEPLRGVCVRAWEKITSSGEQYPSFSAVKQGPKEPYTDFTARLQESLKKMIADSAAQDIVLQLLAFDNANPNCQAALRPIRGKAHLVDYIKVCDGIGGNLHKTTLLAQAMAGLRMDKGNTPFPRACFNCGKHGHTKKECRKKSASQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCV5</accession>
    <name>A0A8I5NCV5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCV5"/>
    <dbReference type="Ensembl" id="ENSPANT00000065173.1">
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        <property type="gene ID" value="ENSPANG00000045640.1"/>
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    <dbReference type="Ensembl" id="ENSPANT00000068909.1">
        <property type="protein sequence ID" value="ENSPANP00000054863.1"/>
        <property type="gene ID" value="ENSPANG00000040207.1"/>
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    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="PYTIAPR"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RVT_1"/>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    <evidence type="ECO:0000313" key="5">
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        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="GLUTAMINE AND SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR14709">
        <property type="entry name" value="GLUTAMINE AND SERINE-RICH PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="1772"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19414"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003908049.1">
        <property type="nucleotide sequence ID" value="XM_003908000.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NEM7"/>
    <dbReference type="SMR" id="A0A8I5NEM7"/>
    <dbReference type="Ensembl" id="ENSPANT00000067893.1">
        <property type="protein sequence ID" value="ENSPANP00000060517.1"/>
        <property type="gene ID" value="ENSPANG00000016304.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018015"/>
    <dbReference type="KEGG" id="panu:101018015"/>
    <dbReference type="CTD" id="10056"/>
    <dbReference type="GeneTree" id="ENSGT00530000063489"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000003">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000007">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000032">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="302"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="589" mass="66224" checksum="8E244826B71F1C5E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NH24</accession>
    <name>A0A8I5NH24_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NH24"/>
    <dbReference type="Ensembl" id="ENSPANT00000066226.1">
        <property type="protein sequence ID" value="ENSPANP00000056771.1"/>
        <property type="gene ID" value="ENSPANG00000046433.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="158" mass="17048" checksum="1EB2942AB91CA830" modified="2022-05-25" version="1">MASATLRMKSKLLTMPDRYCMTRHLAVSPSSDNFFFFLRQSLALLPRLECSGVVTAHCSLTLLGSSSPPASASQVAGTTGTYHLAWLIVIFCIKIQKNKVSLRKRSHFVAQAGLELLALSDPPHSASQSAGITGVSYCAWPQVEVAGLISLGHLFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHH9</accession>
    <name>A0A8I5NHH9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021781842.1">
        <property type="nucleotide sequence ID" value="XM_021926150.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031518358.1">
        <property type="nucleotide sequence ID" value="XM_031662498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHH9"/>
    <dbReference type="Ensembl" id="ENSPANT00000064161.1">
        <property type="protein sequence ID" value="ENSPANP00000060584.1"/>
        <property type="gene ID" value="ENSPANG00000048454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101004743"/>
    <dbReference type="GeneID" id="116273435"/>
    <dbReference type="KEGG" id="panu:101004743"/>
    <dbReference type="KEGG" id="panu:116273435"/>
    <dbReference type="GeneTree" id="ENSGT01150000286990"/>
    <dbReference type="OMA" id="CMSWEIR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="74"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="349" mass="39061" checksum="E6151081E195B38F" modified="2022-05-25" version="1">MHIDLEQSKATVHTIRKASTNNTFGSRQLKNHSMELRNSTLGSGFILVEILNDSGFPELLCATVTVLYMLALISNGLLLLAITMEARLHVPLYLLLGQLSLMDLLFTSVVTPKALVDFLRRENTISFGGCALQMFLALTMGSAEDLLLAFMAYDRFVAICHPLKYMTLMSPRVCWLMVATSWILAFLSALGHTIYTMHFPFCMYWEIRHLLCEIPPLLKLACGDTSRYELIIYVTGVTFLLLPISAIVASYILILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGAATFMYVLPSSFHSPKQDNIISVSYTIVTPALNPLIYSMKNKVVMGTLRRVLGKYRLLLHSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNY2</accession>
    <name>A0A8I5NNY2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021780977.1">
        <property type="nucleotide sequence ID" value="XM_021925285.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPANT00000068005.1">
        <property type="protein sequence ID" value="ENSPANP00000058127.1"/>
        <property type="gene ID" value="ENSPANG00000046073.1"/>
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    <dbReference type="GeneID" id="110741139"/>
    <dbReference type="KEGG" id="panu:110741139"/>
    <dbReference type="GeneTree" id="ENSGT00940000164053"/>
    <dbReference type="OMA" id="TISCRAG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002314">
        <property type="entry name" value="Immunoglobulin kappa variable 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
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    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
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    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158750" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="233" mass="25603" checksum="DD1C0B6540035AF9" modified="2022-05-25" version="1">MASRVQLLSFLFLWISDAREETILTQSPAFVSATPGDKVTISCRAGQDIDDDMNWYQQEPGEAPKLIIKDATTLVSGIPPQFSGSGYGIDFTLTINSMKSEDTAYYFCQQRDNTPITVMNPVTKTSKCSPGVASAAIENIQNVELGGPVVFIMLLHAHATHFLFVSVVSAASMLCLTHLIWQRPGQPSSHCPAVPIISFPSRGKFTWPSPCFLPNSSFPPLRKRETMTKIYLA</sequence>
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    <accession>A0A8I5NQ74</accession>
    <name>A0A8I5NQ74_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPANT00000063269.1">
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        <property type="gene ID" value="ENSPANG00000041240.1"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="188" mass="20586" checksum="9DF6731D9E4B5B95" modified="2022-05-25" version="1">MHQVLQEGNLFSLNKPSIFPKYNQPEEFLFFWFSNSKKCLTQIQFQIICLGKHGSLGDILCFCCCCLGFLFCFVLFCFLRQSLALLPRLECNGAILAHHNLRLPGSSNSPASASQVAGIIGACHYARLIFVFLVETGFCHVGQAGLELPTSDDPSASASQSTGVTGVSHRTWPKMALLTCLVSLSALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQD9</accession>
    <name>A0A8I5NQD9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquinone biosynthesis protein</fullName>
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        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterodimer; two heterodimers of COQ7:COQ9 come together on the same side of the lipid pseudo-bilayer and form a curved tetramer with a hydrophobic surface suitable for membrane interaction. These two tetramers assemble into a soluble octamer with a pseudo-bilayer of lipids captured within. Interacts with COQ7; this interaction allows ubiquinone (CoQ) isoprene intermediates presentation to COQ7 and facilitates the COQ7-mediated hydroxylase step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003916991.2">
        <property type="nucleotide sequence ID" value="XM_003916942.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NQD9"/>
    <dbReference type="Ensembl" id="ENSPANT00000076786.1">
        <property type="protein sequence ID" value="ENSPANP00000051448.1"/>
        <property type="gene ID" value="ENSPANG00000009190.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006640"/>
    <dbReference type="KEGG" id="panu:101006640"/>
    <dbReference type="CTD" id="57017"/>
    <dbReference type="GeneTree" id="ENSGT00390000009328"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="12">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="COQ9 C-terminal" evidence="11">
        <location>
            <begin position="214"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="319" mass="35484" checksum="16A5908C1E546B2B" modified="2022-05-25" version="1">MATAAAVSGALSRAGWKLLQLRCLPVTRCRPALVPRAFHASAVGLRSSDEQKQEPPPSFSQQHSETQGAEKPDPESSHPPPRYTDQGGEEEEGYESEEQLQDRILTAALEFVPTHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTECNARLTRVLEEEQKLVQLGQAEKKKTDQFLRDAVETRLRMLIPYIEHWPRALSVLMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAGIYNTTELVMMQDSSPDFEDTWRFLENRINDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQL3</accession>
    <name>A0A8I5NQL3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NQL3"/>
    <dbReference type="Ensembl" id="ENSPANT00000074125.1">
        <property type="protein sequence ID" value="ENSPANP00000056367.1"/>
        <property type="gene ID" value="ENSPANG00000042892.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="164" mass="18379" checksum="6ADE1AC62B2EB407" modified="2022-05-25" version="1">MLHAYFQLCHIEYQKDRQSRFEIIKSASSRTFIFLRCSLALSPRLECSGAIPAHCNLRLPGSCHSPASASQVGGTTGAHHHARLIFFFFFLRRSLALCPRLECSGAISAHCKLRPPGFTPFSCLSLPSSWDYRRPPPRLANFLVFLVETGFHRVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NRB7</accession>
    <name>A0A8I5NRB7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cerebellin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CBLN4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
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                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Secreted</location>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Javaid M.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
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                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSI2"/>
    <dbReference type="Ensembl" id="ENSPANT00000065535.1">
        <property type="protein sequence ID" value="ENSPANP00000054218.1"/>
        <property type="gene ID" value="ENSPANG00000043555.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000267028"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="56" mass="6443" checksum="116A221A1B014DE4" modified="2022-05-25" version="1">MVNPKDEEPVSLVTPELPYQPWAPPSILPSYGKDIFLYHVRCLLQPNTIPTDTHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NTF3</accession>
    <name>A0A8I5NTF3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NTF3"/>
    <dbReference type="Ensembl" id="ENSPANT00000065917.1">
        <property type="protein sequence ID" value="ENSPANP00000053214.1"/>
        <property type="gene ID" value="ENSPANG00000049126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="122" mass="13965" checksum="756507A26619AD27" modified="2022-05-25" version="1">MCIYTHIYIHTYTYIYFYLISHMYICIHMYFFLFLRRSLALSPRLECSGRISAHCKLRLPGSRHSPASASRVAGTTGARHLARLFFLFLSRDGVSLCSPGWSRSPDLVIRPSRPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUG3</accession>
    <name>A0A8I5NUG3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNG12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892083.1">
        <property type="nucleotide sequence ID" value="XM_003892034.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003892085.1">
        <property type="nucleotide sequence ID" value="XM_003892036.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009208819.1">
        <property type="nucleotide sequence ID" value="XM_009210555.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUG3"/>
    <dbReference type="SMR" id="A0A8I5NUG3"/>
    <dbReference type="Ensembl" id="ENSPANT00000063447.1">
        <property type="protein sequence ID" value="ENSPANP00000055970.1"/>
        <property type="gene ID" value="ENSPANG00000050175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101015176"/>
    <dbReference type="KEGG" id="panu:101015176"/>
    <dbReference type="CTD" id="55970"/>
    <dbReference type="GeneTree" id="ENSGT01100000263497"/>
    <dbReference type="OMA" id="QEKKSCA"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="72" mass="8006" checksum="A4C489A61697FAA9" modified="2022-05-25" version="1">MSSKTASTNNIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLIGIPTSENPFKDKKTCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUN8</accession>
    <name>A0A8I5NUN8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-I</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUN8"/>
    <dbReference type="Ensembl" id="ENSPANT00000078060.1">
        <property type="protein sequence ID" value="ENSPANP00000053766.1"/>
        <property type="gene ID" value="ENSPANG00000041770.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154827"/>
    <dbReference type="OMA" id="WILPTIS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd20526">
        <property type="entry name" value="CYCLIN_CCNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000052">
        <property type="entry name" value="cyclin-I isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00073755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="236" mass="26460" checksum="256B401A8B25EC91" modified="2022-05-25" version="1">MPSNQNISPSQRDEVIQWLAKLKYQFNLYPETFALAGSLLDRFLATVKAHPIYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSSSEILRMEIIILDKLNWDLHTATPLDCLHIFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLRKAQAQTSPRTTASQKCQSEVQQPFTIISQLPVGASRPLLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXL8</accession>
    <name>A0A8I5NXL8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-X-C chemokine receptor type 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">High affinity interleukin-8 receptor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">IL-8 receptor type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CXCR1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with IL8. Interacts with GNAI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009181306.2">
        <property type="nucleotide sequence ID" value="XM_009183042.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779675.2">
        <property type="nucleotide sequence ID" value="XM_021923983.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507377.1">
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    <dbReference type="KEGG" id="panu:101017773"/>
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    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="entry name" value="CELL ADHESION MOLECULE"/>
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        <property type="entry name" value="7tm_1"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="PRINTS" id="PR00427">
        <property type="entry name" value="INTRLEUKIN8R"/>
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        <property type="entry name" value="INTRLEUKN8AR"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="10 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="243"/>
            <end position="265"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="57"/>
            <end position="306"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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            <dbReference type="RuleBase" id="RU000688"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="351" mass="39809" checksum="034010619D7FD5EA" modified="2022-05-25" version="1">MSNATDPQMWGDDFDLNFTGMPPTDEDYSPCRLETESLNKYVVIVTYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLAMADLLFALTLPIWAASKVNGWIFGTLLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLIQKRHSVRFVCLICWGLSVILSLPFFLFRQAYHRNNSSPVCYEVLGNDTAKWRMVLRIVPHTFGFILPLLIMLFCYGFTLHTLFKAHIGQKHRAMKVIFAVVLIFLLCWLPYHLVLLADTLMRTHLIKESCERRDDIGRALDATEILGVLHSCLNPIIYAFIGQNFRHGFLKILATHGLVSKEFLARHHVTSYTSSSVNVSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P002</accession>
    <name>A0A8I5P002_PAPAN</name>
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        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P002"/>
    <dbReference type="Ensembl" id="ENSPANT00000061061.1">
        <property type="protein sequence ID" value="ENSPANP00000057090.1"/>
        <property type="gene ID" value="ENSPANG00000037439.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161886"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF51">
        <property type="entry name" value="GRANZYME M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="209" mass="22276" checksum="3049CA9525D3CE27" modified="2022-05-25" version="1">MMAVWLHPRVLFETLSKMLVGGGFRVCSGGRGCDSSPPQEASVWSSGPGPAPTLGLHSSMESSLLVLALGALLVGSSFETQIIGGREVIPHSRPYMASLQRGGSHLCGGVLVHPKWVLTAAHCLVQRCGLIQALTGGTLEHVCLPALLHCQEACLTRRQRLTPSVPWKEGLALSNGGTLRRIGRCQPLYKSLWLSLGPQVKGIPRAGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P090</accession>
    <name>A0A8I5P090_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021793646.1">
        <property type="nucleotide sequence ID" value="XM_021937954.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P090"/>
    <dbReference type="Ensembl" id="ENSPANT00000070330.1">
        <property type="protein sequence ID" value="ENSPANP00000061131.1"/>
        <property type="gene ID" value="ENSPANG00000049180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110743182"/>
    <dbReference type="KEGG" id="panu:110743182"/>
    <dbReference type="GeneTree" id="ENSGT00390000012138"/>
    <dbReference type="OMA" id="RSMPEQP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="7">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="108" mass="11928" checksum="9E509EFC72EB0172" modified="2022-05-25" version="1">MKKSLESINSRLQLMESGKYMLGYKQTLKMIRQGTPKLVILANNCPALKKSEIEYYAMLAKIGVHHYSGNNIELGTACGKYYRGCTLALTDPGDSAIIRSMPEQPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P384</accession>
    <name>A0A8I5P384_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5P384"/>
    <dbReference type="Ensembl" id="ENSPANT00000066615.1">
        <property type="protein sequence ID" value="ENSPANP00000059935.1"/>
        <property type="gene ID" value="ENSPANG00000039813.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154460"/>
    <dbReference type="OMA" id="ISGHEML"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002491">
        <property type="entry name" value="T cell receptor beta variable 12-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050413">
        <property type="entry name" value="TCR_beta_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268:SF20">
        <property type="entry name" value="T CELL RECEPTOR BETA VARIABLE 7-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268">
        <property type="entry name" value="T-CELL RECEPTOR BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-1279">T cell receptor</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196692" description="Immunoglobulin V-set domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="13">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="132" mass="14498" checksum="50FFB4D0F23470C6" modified="2022-05-25" version="1">MGTRLLCWVVLGFLGTDHTGARVSQSPRYKVTKRGQDVALRCDPISGHDYLYWYQQALGQGPELLTYFSYEAQPDKSGLPSDRFSAERPEGSVSTLKIQPLAKAVGLLAMYLCASSLATARARLPPSCSQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P3J7</accession>
    <name>A0A8I5P3J7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P3J7"/>
    <dbReference type="Ensembl" id="ENSPANT00000065476.1">
        <property type="protein sequence ID" value="ENSPANP00000060271.1"/>
        <property type="gene ID" value="ENSPANG00000039167.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166898"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266269" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10482" checksum="F2A311E5C0411DB4" modified="2022-05-25" version="1">LHLFFFFFFLRWSLTLSPRLECSGAISAHCNLCLLSSSDSPASASRVAVTTGAHHHVWLIFCIFSRDRVSLYYPVSASRVAGITEVPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZF5</accession>
    <name>A0A8I5QZF5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NFIL3 like basic leucine zipper</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NFILZ</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZF5"/>
    <dbReference type="Ensembl" id="ENSPANT00000062526.1">
        <property type="protein sequence ID" value="ENSPANP00000049066.1"/>
        <property type="gene ID" value="ENSPANG00000043417.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164108"/>
    <dbReference type="OMA" id="CHLLDGH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF7">
        <property type="entry name" value="NFIL3 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="289" mass="31205" checksum="44D29F800057E7D5" modified="2022-05-25" version="1">MDVGFLGLSDVSQSHSKTLWGARGRGPTIRRQREFMPEEKKDTVYWEKRRKNNEAAKRSREKRRLNDAAIEGRLAALMEENALLRGELKALKLRFGLLPLTGGPRALPLQALLWEAPWTGDPRPGAEALSSLSGSHNCLLRPCSLDAGIPGCRGCLLAPRWTGLATSPRSPQESAPPTFNRIDMALQTGLPPALFSCHLLDGHVGSRPELRPCWGLWSPMPSGCRASGPSDVLLTSTADPMGLSPGVTCPVPGNSHEGLGQPSLPHKLRIKSRASGRVPCGWEGGQAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZZ0</accession>
    <name>A0A8I5QZZ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein NDNF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NDNF</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
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        <source>
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            <dbReference type="Ensembl" id="ENSPANP00000050626.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2D0</accession>
    <name>A0A8I5R2D0_PAPAN</name>
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        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit NDUFA4</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="10">Belongs to the complex IV NDUFA4 subunit family.</text>
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        <property type="gene ID" value="ENSPANG00000045495.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="B12D"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT NDUFA4"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
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    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041121"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059138.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="82" mass="9226" checksum="B263DF8DEF876BC6" modified="2022-05-25" version="1">MLCQIITQSKKHLSLIPLFVFIGAGGTGAALYLSCLALFNPDVSWDRKSNPEPWNKLGPNDQYKFYSVNVDYSKLKKEGPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKZ1</accession>
    <name>A0A096MKZ1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IGF like family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IGFL3</name>
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    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IGFL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003919413.1">
        <property type="nucleotide sequence ID" value="XM_003919364.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009198127.1">
        <property type="nucleotide sequence ID" value="XM_009199863.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKZ1"/>
    <dbReference type="Ensembl" id="ENSPANT00000004140.3">
        <property type="protein sequence ID" value="ENSPANP00000000180.3"/>
        <property type="gene ID" value="ENSPANG00000019926.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023542"/>
    <dbReference type="KEGG" id="panu:101023542"/>
    <dbReference type="CTD" id="388555"/>
    <dbReference type="eggNOG" id="ENOG502TJ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009557"/>
    <dbReference type="HOGENOM" id="CLU_148773_0_0_1"/>
    <dbReference type="OMA" id="VWGITVF"/>
    <dbReference type="OrthoDB" id="9834561at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019926">
        <property type="expression patterns" value="Expressed in zone of skin and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032744">
        <property type="entry name" value="IGFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34827:SF5">
        <property type="entry name" value="INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34827">
        <property type="entry name" value="INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14653">
        <property type="entry name" value="IGFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315334" evidence="5">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000180.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="117" mass="12985" checksum="3AEC983CCA95CC33" modified="2022-05-25" version="3">MMPRCCILVLVWGITVFLSHCSQGTTDAPVDSGPWLCQPAPRCGNKIYNPSEQCCYDDAILSLEQTRRCGSNCTFWPCFELCCPESFGPQQKFLVKLKVLGMKSQCHSSPISRSCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ML03</accession>
    <name>A0A096ML03_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat and SOCS box protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ASB17</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892136.1">
        <property type="nucleotide sequence ID" value="XM_003892087.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096ML03"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000195"/>
    <dbReference type="Ensembl" id="ENSPANT00000006430.3">
        <property type="protein sequence ID" value="ENSPANP00000000195.1"/>
        <property type="gene ID" value="ENSPANG00000022782.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007139"/>
    <dbReference type="KEGG" id="panu:101007139"/>
    <dbReference type="CTD" id="127247"/>
    <dbReference type="eggNOG" id="ENOG502QVW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018077"/>
    <dbReference type="HOGENOM" id="CLU_082443_0_0_1"/>
    <dbReference type="OMA" id="KLCHKTS"/>
    <dbReference type="OrthoDB" id="6419934at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022782">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061831">
        <property type="term" value="C:apical ectoplasmic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150147">
        <property type="term" value="P:cell-cell junction disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160087">
        <property type="term" value="P:spermatid cytoplasm removal during spermiation of flagellated sperm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039147">
        <property type="entry name" value="ASB17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="7">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="295" mass="34400" checksum="AC734E738D89BA34" modified="2014-11-26" version="1">MSKSTKLCRKTSCPRSNIFCNLLDKIVKRPSLQFLGQWGYHCYEPRIYRSLAKILRYVDLDGFDALLTDYIAFVEKSGYRFEVSFNLDFTEICVNTILYWVFARKGNPDFVELLLKKTKDYVQDRSCNLALIWRTFTPVYCPSPLSGITPLFYVAQTRQSNIFKILLQYGILEREKNPINIVLTIVLYPSRVRVMVDRELADIHEDAKTCLVLCSRVLSVISVKEIKTQLSLGRRPIISNWFDYIPSTRYKDPCELLHLCRLTIRNQLLTNNMLPDGIFSLLIPARLQNYLNLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ML07</accession>
    <name>A0A096ML07_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIGN</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_003914494.4">
        <property type="nucleotide sequence ID" value="XM_003914445.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017807306.2">
        <property type="nucleotide sequence ID" value="XM_017951817.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017807307.2">
        <property type="nucleotide sequence ID" value="XM_017951818.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017807308.2">
        <property type="nucleotide sequence ID" value="XM_017951819.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017807309.2">
        <property type="nucleotide sequence ID" value="XM_017951820.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017807310.2">
        <property type="nucleotide sequence ID" value="XM_017951821.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021785887.2">
        <property type="nucleotide sequence ID" value="XM_021930195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096ML07"/>
    <dbReference type="Ensembl" id="ENSPANT00000009852.3">
        <property type="protein sequence ID" value="ENSPANP00000000199.2"/>
        <property type="gene ID" value="ENSPANG00000012687.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101021014"/>
    <dbReference type="KEGG" id="panu:101021014"/>
    <dbReference type="CTD" id="23556"/>
    <dbReference type="GeneTree" id="ENSGT00390000017600"/>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012687">
        <property type="expression patterns" value="Expressed in esophagus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096ML07">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000020">
        <property type="entry name" value="Phosphatidylinositol glycan anchor biosynthesis class N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="787"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="430"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000199.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="931" mass="105783" checksum="0C103D795EFECA39" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MM22</accession>
    <name>A0A096MM22_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras association domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RASSF3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MM22"/>
    <dbReference type="Ensembl" id="ENSPANT00000027467.3">
        <property type="protein sequence ID" value="ENSPANP00000000634.3"/>
        <property type="gene ID" value="ENSPANG00000009139.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157502"/>
    <dbReference type="HOGENOM" id="CLU_045544_1_1_1"/>
    <dbReference type="OMA" id="YCRDLVH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009139">
        <property type="expression patterns" value="Expressed in fundus of stomach and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MM22">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17219">
        <property type="entry name" value="RA_RASSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000224">
        <property type="entry name" value="ras association domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF8">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="79"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="9">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000634.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="233" mass="26872" checksum="421511757B56C396" modified="2022-05-25" version="3">MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCRPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLRGRYAAYRHKLEEALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMM1</accession>
    <name>A0A096MMM1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation channel sperm associated 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CATSPER3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003900163.1">
        <property type="nucleotide sequence ID" value="XM_003900114.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MMM1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000856"/>
    <dbReference type="Ensembl" id="ENSPANT00000008448.3">
        <property type="protein sequence ID" value="ENSPANP00000000856.1"/>
        <property type="gene ID" value="ENSPANG00000005114.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997920"/>
    <dbReference type="KEGG" id="panu:100997920"/>
    <dbReference type="CTD" id="347732"/>
    <dbReference type="eggNOG" id="KOG2302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161455"/>
    <dbReference type="HOGENOM" id="CLU_058058_0_0_1"/>
    <dbReference type="OMA" id="YETMAVY"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005114">
        <property type="expression patterns" value="Expressed in testis and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MMM1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000186">
        <property type="entry name" value="Cation channel sperm-associated protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47131">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47131:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="50"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="398" mass="46276" checksum="EF1B29169DCB220D" modified="2014-11-26" version="1">MSQHRHQSQSRVLSSSPVDTTSVGFCPTFKTFKRKDDECRAFVKKVIMSRFFKIIMISTVTSNGFFMALWTSYEIRYRLFRLLELSEIFFVSICTSELSMKLYVDPINYWKNGYNVLDVIVMIIMLLPYTVRELMGRQFSYVHIADGMQSLRILKLISYSRGIRTLIIAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSADKGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIKKFERELMLERQVTLMGEKQVILQRQQEEISRLMHIQENADCKSFSELVENFKKTLHHTDPMVLDDFGTSLPFIDIYFSTLDYQDTTVHKLQELYYEIAHVLGLMLEDLPQEKPQSLEKVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNK4</accession>
    <name>A0A096MNK4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Copine-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Copine VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CPNE8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021777871.1">
        <property type="nucleotide sequence ID" value="XM_021922179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNK4"/>
    <dbReference type="Ensembl" id="ENSPANT00000000631.3">
        <property type="protein sequence ID" value="ENSPANP00000001235.3"/>
        <property type="gene ID" value="ENSPANG00000013195.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022598"/>
    <dbReference type="CTD" id="144402"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159679"/>
    <dbReference type="HOGENOM" id="CLU_020452_3_2_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013195">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MNK4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000071">
        <property type="entry name" value="Copine 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF133">
        <property type="entry name" value="COPINE-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="142"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="309"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001235.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="564" mass="63067" checksum="A792BB4A64369F11" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MP17</accession>
    <name>A0A096MP17_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase nu</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">POLN</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with FANCD2, FANCI, PCNA, RAD51 and HELQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096MP17"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001450"/>
    <dbReference type="Ensembl" id="ENSPANT00000006796.3">
        <property type="protein sequence ID" value="ENSPANP00000001450.3"/>
        <property type="gene ID" value="ENSPANG00000000640.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159015"/>
    <dbReference type="HOGENOM" id="CLU_004675_2_1_1"/>
    <dbReference type="OMA" id="RFLIMSN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000640">
        <property type="expression patterns" value="Expressed in subcutaneous adipose tissue and 32 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08638">
        <property type="entry name" value="DNA_pol_A_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000002">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.10:FF:000001">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000070">
        <property type="entry name" value="DNA polymerase nu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.370:FF:000008">
        <property type="entry name" value="DNA polymerase nu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.10">
        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040940">
        <property type="entry name" value="DNA_pol_P_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF27">
        <property type="entry name" value="DNA POLYMERASE NU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18049">
        <property type="entry name" value="DNA_pol_P_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="604"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="867"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001450.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="900" mass="100710" checksum="4264AEAD7557344D" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPH1</accession>
    <name>A0A096MPH1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-hydroxytryptamine receptor 2C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Serotonin receptor 2C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HTR2C</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with MPDZ. Interacts with ARRB2. Interacts with MPP3; this interaction stabilizes the receptor at the plasma membrane and prevents the desensitization of the HTR2C receptor-mediated calcium response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021788245.1">
        <property type="nucleotide sequence ID" value="XM_021932553.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MPH1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001627"/>
    <dbReference type="Ensembl" id="ENSPANT00000017733.3">
        <property type="protein sequence ID" value="ENSPANP00000001627.1"/>
        <property type="gene ID" value="ENSPANG00000010092.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013950"/>
    <dbReference type="KEGG" id="panu:101013950"/>
    <dbReference type="CTD" id="3358"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244937"/>
    <dbReference type="HOGENOM" id="CLU_009579_11_3_1"/>
    <dbReference type="OMA" id="YRNGNEF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010092">
        <property type="expression patterns" value="Expressed in suprachiasmatic nucleus and 29 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098666">
        <property type="term" value="C:G protein-coupled serotonin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="F:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001587">
        <property type="term" value="F:Gq/11-coupled serotonin receptor activity"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="term" value="F:neurotransmitter receptor activity"/>
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        <property type="term" value="P:cGMP-mediated signaling"/>
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        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="term" value="P:feeding behavior"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
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        <property type="term" value="P:phospholipase C-activating serotonin receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
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        <property type="term" value="P:serotonin receptor signaling pathway"/>
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    <dbReference type="CDD" id="cd15305">
        <property type="entry name" value="7tmA_5-HT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000377">
        <property type="entry name" value="5HT2C_rcpt"/>
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    <dbReference type="InterPro" id="IPR002231">
        <property type="entry name" value="5HT_rcpt"/>
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    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF32">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 2C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00517">
        <property type="entry name" value="5HT2CRECEPTR"/>
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        <property type="entry name" value="5HTRECEPTOR"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0085">Behavior</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001921600" description="5-hydroxytryptamine receptor 2C" evidence="18">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="70"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="458" mass="51804" checksum="97C49146FA7D180E" modified="2014-11-26" version="1">MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEDKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENAANPNQDQNARRRRKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIKKASDNEPGIEMQVENLELPVNPSSVVSERISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRY3</accession>
    <name>A0A096MRY3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">ADAM metallopeptidase with thrombospondin type 1 motif 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ADAMTS6</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017815071.2">
        <property type="nucleotide sequence ID" value="XM_017959582.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRY3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002542"/>
    <dbReference type="Ensembl" id="ENSPANT00000006045.3">
        <property type="protein sequence ID" value="ENSPANP00000002542.3"/>
        <property type="gene ID" value="ENSPANG00000012117.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024212"/>
    <dbReference type="KEGG" id="panu:101024212"/>
    <dbReference type="CTD" id="11174"/>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156571"/>
    <dbReference type="HOGENOM" id="CLU_000660_1_1_1"/>
    <dbReference type="OMA" id="GPEWRHD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012117">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 37 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRY3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
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    <keyword evidence="2" id="KW-0964">Secreted</keyword>
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            <position position="407"/>
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            <position position="413"/>
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            <name>Zn(2+)</name>
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            <label>1</label>
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    </feature>
    <feature type="disulfide bond" evidence="17">
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            <begin position="490"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002542.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125320" checksum="C588AD19E823A5AB" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTJ1</accession>
    <name>A0A096MTJ1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell death inducing DFFA like effector a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CIDEA</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="CIDE_N"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="105"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003125.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="214" mass="23975" checksum="C27C439DAB6920D2" modified="2022-05-25" version="2">MACTCSPSYSGVLLFTTIFRPLTFMGSQTKRVLLGAPRLSSRRGVMASSLQELISKTLDALVITTGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMLGSKHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCMGLKGLLRSLLRFLSYSAQVTGQFLVYMGTYMLRVLDDKEERPSLRSQAKGRFTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTT7</accession>
    <name>A0A096MTT7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MCF.2 cell line derived transforming sequence-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MCF2L2</name>
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    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCF2 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003894766.5"/>
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        <property type="gene ID" value="ENSPANG00000017801.3"/>
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    <dbReference type="GeneID" id="101015203"/>
    <dbReference type="KEGG" id="panu:101015203"/>
    <dbReference type="CTD" id="23101"/>
    <dbReference type="eggNOG" id="KOG4240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161734"/>
    <dbReference type="HOGENOM" id="CLU_007130_0_0_1"/>
    <dbReference type="OMA" id="KGIVFCK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017801">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 48 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTT7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
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    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
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    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
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        <property type="entry name" value="DH_dom"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
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        <property type="entry name" value="SOS1_NGEF_PH"/>
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    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF201">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Spectrin_5"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="193"/>
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        <location>
            <begin position="619"/>
            <end position="822"/>
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        <location>
            <begin position="834"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="589"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1114"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="579"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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        <location>
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            <begin position="1043"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003230.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1114" mass="126775" checksum="054CA6E643FDEE9B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MV40</accession>
    <name>A0A096MV40_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BTB/POZ domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BTBD8</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts (via N-terminus) with adapter protein complex AP-2 subunits alpha (AP2A1) and beta (AP2B1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000003715"/>
    <dbReference type="Ensembl" id="ENSPANT00000002800.4">
        <property type="protein sequence ID" value="ENSPANP00000003715.3"/>
        <property type="gene ID" value="ENSPANG00000005230.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154382"/>
    <dbReference type="OMA" id="CIPERAN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005230">
        <property type="expression patterns" value="Expressed in visual cortex and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098850">
        <property type="term" value="C:extrinsic component of synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18490">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18285">
        <property type="entry name" value="BTB1_POZ_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18286">
        <property type="entry name" value="BTB2_POZ_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000129">
        <property type="entry name" value="BTB/POZ domain-containing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000166">
        <property type="entry name" value="BTB/POZ domain-containing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043225">
        <property type="entry name" value="BACK_BTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040121">
        <property type="entry name" value="BTBD8_BTB_POZ_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027907">
        <property type="entry name" value="BTBD8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26017">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15363">
        <property type="entry name" value="BTBD8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="206"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="789"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="917"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1377"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1576"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1576"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1598"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003715.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1794" mass="198974" checksum="5C5ACB22F6FB37D9" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWH3</accession>
    <name>A0A096MWH3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MWH3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004229"/>
    <dbReference type="Ensembl" id="ENSPANT00000019322.3">
        <property type="protein sequence ID" value="ENSPANP00000004229.2"/>
        <property type="gene ID" value="ENSPANG00000017577.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063340"/>
    <dbReference type="HOGENOM" id="CLU_007874_3_1_1"/>
    <dbReference type="OMA" id="QGQYCKL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017577">
        <property type="expression patterns" value="Expressed in pituitary gland"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="214"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004229.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="623" mass="69386" checksum="3F6ABA1B55471D35" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWN4</accession>
    <name>A0A096MWN4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KRAB-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MWN4"/>
    <dbReference type="Ensembl" id="ENSPANT00000024038.3">
        <property type="protein sequence ID" value="ENSPANP00000004292.1"/>
        <property type="gene ID" value="ENSPANG00000016327.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RU1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012484"/>
    <dbReference type="HOGENOM" id="CLU_097196_1_0_1"/>
    <dbReference type="OMA" id="ADEFAHF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016327">
        <property type="expression patterns" value="Expressed in duodenum"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019041">
        <property type="entry name" value="SSXRD_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14112:SF24">
        <property type="entry name" value="PROTEIN SSX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14112">
        <property type="entry name" value="SYNOVIAL SARCOMA, X MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09514">
        <property type="entry name" value="SSXRD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="191" mass="22014" checksum="E21F356BD836E0EB" modified="2014-11-26" version="1">MNSDDAFARRPNVGAQIPEKIQKAFDDIAKCFSKKEWEKMKYSEKIVYVYMKRKYEAMTKLGFRVTLPPFMHNKRATDFQRNDFDNDRNRGNQVERPQLSTFSMLQGIFPKIMPKKPAPAEEGNDLKGVSETSGPKNDGKQLCPPGKANTSEKTNKRSGPKRGKHAWTHRLCERKQLVIYEEISGPEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWR8</accession>
    <name>A0A096MWR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase 15</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin thioesterase 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-specific-processing protease 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">USP15</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo. Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. May interact with PRKN. Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A096MWR8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004326"/>
    <dbReference type="Ensembl" id="ENSPANT00000020108.3">
        <property type="protein sequence ID" value="ENSPANP00000004326.2"/>
        <property type="gene ID" value="ENSPANG00000011242.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154932"/>
    <dbReference type="HOGENOM" id="CLU_001060_7_1_1"/>
    <dbReference type="OMA" id="PCHAQQS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011242">
        <property type="expression patterns" value="Expressed in bone marrow and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWR8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005160">
        <property type="term" value="F:transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061649">
        <property type="term" value="F:ubiquitin-modified histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035520">
        <property type="term" value="P:monoubiquitinated protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905035">
        <property type="term" value="P:negative regulation of antifungal innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900246">
        <property type="term" value="P:positive regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990167">
        <property type="term" value="P:protein K27-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902238">
        <property type="term" value="P:regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2230.10:FF:000003">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000013">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000034">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000020">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF28">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="19">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="289"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="629"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="967"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004326.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="996" mass="113799" checksum="E61D924967393DC6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXA1</accession>
    <name>A0A096MXA1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 292</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF292</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897925.3">
        <property type="nucleotide sequence ID" value="XM_003897876.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021793271.2">
        <property type="nucleotide sequence ID" value="XM_021937579.2"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000004512"/>
    <dbReference type="Ensembl" id="ENSPANT00000008947.3">
        <property type="protein sequence ID" value="ENSPANP00000004512.3"/>
        <property type="gene ID" value="ENSPANG00000007401.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024065"/>
    <dbReference type="KEGG" id="panu:101024065"/>
    <dbReference type="CTD" id="23036"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183034"/>
    <dbReference type="HOGENOM" id="CLU_000520_0_0_1"/>
    <dbReference type="OMA" id="LIVFKQC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007401">
        <property type="expression patterns" value="Expressed in axillary lymph node and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MXA1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001066">
        <property type="entry name" value="Zinc finger protein 292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001293">
        <property type="entry name" value="Zinc finger protein 292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052251">
        <property type="entry name" value="GH-ZnFinger_Regulators"/>
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        <property type="entry name" value="TPR_Rlf/292/654"/>
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        <property type="entry name" value="zf_C2H2_ZNF292/Rlf"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN 292"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25580">
        <property type="entry name" value="TPR_Rlf"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25420">
        <property type="entry name" value="zf-C2H2_ZN292"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF26218">
        <property type="entry name" value="zf_C2H2_ZNF292"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
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    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
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    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
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            <begin position="568"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
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            <begin position="721"/>
            <end position="748"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="749"/>
            <end position="778"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1097"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1375"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1948"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="2115"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="2173"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="2257"/>
            <end position="2287"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="607"/>
            <end position="632"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="824"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1296"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1329"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1589"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1987"/>
            <end position="2024"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2078"/>
            <end position="2104"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2286"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2442"/>
            <end position="2481"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2506"/>
            <end position="2569"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2608"/>
            <end position="2632"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="615"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="824"/>
            <end position="833"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="843"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="884"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="895"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <begin position="1296"/>
            <end position="1309"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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            <begin position="1341"/>
            <end position="1355"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <begin position="1589"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1995"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="2079"/>
            <end position="2098"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="2286"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="2313"/>
            <end position="2323"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2442"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2454"/>
            <end position="2471"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2506"/>
            <end position="2523"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067168"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004512.3"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="2724" mass="305081" checksum="2E78057C26036759" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXE2</accession>
    <name>A0A096MXE2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diversin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANKRD6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
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                <person name="Puazo M.P."/>
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                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="4">Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.</text>
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    <sequence length="727" mass="79793" checksum="A6CB8445C39A8E65" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXL4</accession>
    <name>A0A096MXL4_PAPAN</name>
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        <recommendedName>
            <fullName evidence="2">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1</fullName>
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        <alternativeName>
            <fullName evidence="8">HepA-related protein</fullName>
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            <fullName evidence="7">Sucrose nonfermenting protein 2-like 1</fullName>
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        <name evidence="17" type="primary">SMARCAL1</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with RPA2; the interaction is direct and mediates the recruitment by the RPA complex of SMARCAL1 to sites of DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021779658.2">
        <property type="nucleotide sequence ID" value="XM_021923966.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507358.1">
        <property type="nucleotide sequence ID" value="XM_031651498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507359.1">
        <property type="nucleotide sequence ID" value="XM_031651499.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507360.1">
        <property type="nucleotide sequence ID" value="XM_031651500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MXL4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004632"/>
    <dbReference type="Ensembl" id="ENSPANT00000012731.3">
        <property type="protein sequence ID" value="ENSPANP00000004632.3"/>
        <property type="gene ID" value="ENSPANG00000017812.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010283"/>
    <dbReference type="KEGG" id="panu:101010283"/>
    <dbReference type="CTD" id="50485"/>
    <dbReference type="eggNOG" id="KOG1000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157608"/>
    <dbReference type="HOGENOM" id="CLU_000315_33_1_1"/>
    <dbReference type="OMA" id="KCVPHAE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017812">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036310">
        <property type="term" value="F:ATP-dependent DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001036">
        <property type="entry name" value="SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000026">
        <property type="entry name" value="SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07443">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HARP" evidence="16">
        <location>
            <begin position="226"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HARP" evidence="16">
        <location>
            <begin position="322"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="440"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="711"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004632.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="949" mass="105272" checksum="0E95B154BF5C68E6" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYH1</accession>
    <name>A0A096MYH1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Leucyl-cystinyl aminopeptidase</fullName>
            <ecNumber evidence="19">3.4.11.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Oxytocinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LNPEP</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.</text>
            <dbReference type="EC" id="3.4.11.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Binds tankyrases 1 and 2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.3" evidence="19"/>
    <dbReference type="RefSeq" id="XP_003899996.2">
        <property type="nucleotide sequence ID" value="XM_003899947.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYH1"/>
    <dbReference type="Ensembl" id="ENSPANT00000016582.3">
        <property type="protein sequence ID" value="ENSPANP00000004986.3"/>
        <property type="gene ID" value="ENSPANG00000010943.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101013078"/>
    <dbReference type="KEGG" id="panu:101013078"/>
    <dbReference type="CTD" id="4012"/>
    <dbReference type="GeneTree" id="ENSGT00940000157902"/>
    <dbReference type="OMA" id="AWDFIQV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010943">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MYH1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000010">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000003">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF42">
        <property type="entry name" value="LEUCYL-CYSTINYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 23" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="173"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="392"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="689"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="24">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004986.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1025" mass="117345" checksum="A8A69CD147A86F20" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1F2</accession>
    <name>A0A096N1F2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KIAA0408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KIAA0408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021793595.2">
        <property type="nucleotide sequence ID" value="XM_021937903.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021793596.2">
        <property type="nucleotide sequence ID" value="XM_021937904.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031523314.1">
        <property type="nucleotide sequence ID" value="XM_031667454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1F2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006120"/>
    <dbReference type="Ensembl" id="ENSPANT00000028610.3">
        <property type="protein sequence ID" value="ENSPANP00000006120.3"/>
        <property type="gene ID" value="ENSPANG00000011914.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014381"/>
    <dbReference type="KEGG" id="panu:101014381"/>
    <dbReference type="CTD" id="9729"/>
    <dbReference type="eggNOG" id="ENOG502RJ9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001962"/>
    <dbReference type="HOGENOM" id="CLU_024871_0_0_1"/>
    <dbReference type="OMA" id="MPNVINM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011914">
        <property type="expression patterns" value="Expressed in visual cortex and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027882">
        <property type="entry name" value="SOGA1/2-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15705">
        <property type="entry name" value="MCG7194, ISOFORM CRA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15705:SF1">
        <property type="entry name" value="RIKEN CDNA 9330159F19 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14818">
        <property type="entry name" value="SOGA1-2-like_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOGA 1/2-like coiled-coil" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
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            <begin position="259"/>
            <end position="285"/>
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            <begin position="637"/>
            <end position="694"/>
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        <location>
            <begin position="15"/>
            <end position="49"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="283"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="663"/>
            <end position="677"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="694"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006120.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="694" mass="79182" checksum="5D35DCAA995CDD2E" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1N0</accession>
    <name>A0A096N1N0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="11" type="primary">LDHAL6A</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
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    <dbReference type="STRING" id="9555.ENSPANP00000006207"/>
    <dbReference type="Ensembl" id="ENSPANT00000009287.3">
        <property type="protein sequence ID" value="ENSPANP00000006207.2"/>
        <property type="gene ID" value="ENSPANG00000008347.3"/>
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    <dbReference type="HOGENOM" id="CLU_045401_0_2_1"/>
    <dbReference type="OMA" id="TARFRFF"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
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    <dbReference type="Bgee" id="ENSPANG00000008347">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="L-lactate dehydrogenase A chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="L-lactate dehydrogenase A chain"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="L-LACTATE DEHYDROGENASE A-LIKE 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00064">
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
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            <begin position="22"/>
            <end position="160"/>
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            <begin position="164"/>
            <end position="328"/>
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    <feature type="active site" description="Proton acceptor" evidence="6">
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            <position position="193"/>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="32"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="52"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="113"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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            <begin position="136"/>
            <end position="138"/>
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        <ligand>
            <name>NAD(+)</name>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="RuleBase" id="RU000496"/>
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            <dbReference type="Pfam" id="PF02866"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006207.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="332" mass="36556" checksum="FCF9C644AAA2AEB0" modified="2018-02-28" version="2">MATVKSELIKNFTKEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDADEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSAFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEEIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N3Y9</accession>
    <name>A0A096N3Y9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V(D)J recombination-activating protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RAG2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAG2 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003910018.5"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000007084"/>
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        <property type="protein sequence ID" value="ENSPANP00000007084.2"/>
        <property type="gene ID" value="ENSPANG00000010008.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000786"/>
    <dbReference type="KEGG" id="panu:101000786"/>
    <dbReference type="CTD" id="5897"/>
    <dbReference type="eggNOG" id="ENOG502QVKU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000012559"/>
    <dbReference type="HOGENOM" id="CLU_516740_0_0_1"/>
    <dbReference type="OMA" id="MIFCSRG"/>
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        <property type="component" value="Chromosome 12"/>
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    <dbReference type="Bgee" id="ENSPANG00000010008">
        <property type="expression patterns" value="Expressed in thymus and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097519">
        <property type="term" value="C:DNA recombinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
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        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
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        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:B cell homeostatic proliferation"/>
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        <property type="term" value="P:B cell lineage commitment"/>
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        <property type="term" value="P:defense response to bacterium"/>
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        <property type="term" value="P:DN2 thymocyte differentiation"/>
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    <dbReference type="GO" id="GO:0035265">
        <property type="term" value="P:organ growth"/>
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    <dbReference type="GO" id="GO:0046622">
        <property type="term" value="P:positive regulation of organ growth"/>
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        <property type="term" value="P:pre-B cell allelic exclusion"/>
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        <property type="term" value="P:T cell lineage commitment"/>
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        <property type="term" value="P:V(D)J recombination"/>
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        <property type="entry name" value="Kelch-type beta propeller"/>
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        <property type="entry name" value="Rag2 PHD finger"/>
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        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
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        <property type="entry name" value="RAG2_PHD"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10960">
        <property type="entry name" value="V D J RECOMBINATION-ACTIVATING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10960:SF0">
        <property type="entry name" value="V(D)J RECOMBINATION-ACTIVATING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03089">
        <property type="entry name" value="RAG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13341">
        <property type="entry name" value="RAG2_PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Recombination activating protein 2 PHD" evidence="13">
        <location>
            <begin position="419"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="428"/>
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        <ligand>
            <name>Zn(2+)</name>
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="451"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="457"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="460"/>
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        <ligand>
            <name>Zn(2+)</name>
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="463"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
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        <ligand>
            <name>Zn(2+)</name>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="486"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008254"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00021275"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00063383"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007084.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="532" mass="59888" checksum="8B0349974B622A3E" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N500</accession>
    <name>A0A096N500_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PYROXD1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response. Required for normal sarcomere structure and muscle fiber integrity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
            <location evidence="3">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009178608.2">
        <property type="nucleotide sequence ID" value="XM_009180344.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N500"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007504"/>
    <dbReference type="Ensembl" id="ENSPANT00000022539.3">
        <property type="protein sequence ID" value="ENSPANP00000007504.3"/>
        <property type="gene ID" value="ENSPANG00000020209.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005993"/>
    <dbReference type="KEGG" id="panu:101005993"/>
    <dbReference type="CTD" id="79912"/>
    <dbReference type="eggNOG" id="KOG2755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014894"/>
    <dbReference type="HOGENOM" id="CLU_026335_0_0_1"/>
    <dbReference type="OMA" id="MCENLIL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020209">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000009">
        <property type="entry name" value="Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000165">
        <property type="entry name" value="Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000176">
        <property type="entry name" value="Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000181">
        <property type="entry name" value="Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="12"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="287"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-rubredoxin oxidoreductase C-terminal" evidence="16">
        <location>
            <begin position="413"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007504.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="500" mass="55816" checksum="4B74413AE93E5940" modified="2022-05-25" version="3">MEAARPPATAGKFVVVGGGIAGVTCAEQLATQFPSEDILLITASPVIKAVTNFKQISKILEEFDVEEQSSTMLEKRFPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFLTSKLIAEKPEAKIAQKRTRYTTEGRKKEARSKSKADNVGSALGPDWHEGLNLKGTKEFSHRIHLETMCEVKKIYLQDEFRILKKKSFTFPRDPKSVTTDTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFNLGEDGGLKVDDHMHTSLPDVYAAGDICTASWQLSPVWQQMRLWTQARQMGWYAAKCMAAASLGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGQEYIKVVMQNGRMMGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5S5</accession>
    <name>A0A096N5S5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBXO34</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096N5S5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007789"/>
    <dbReference type="Ensembl" id="ENSPANT00000000796.3">
        <property type="protein sequence ID" value="ENSPANP00000007789.2"/>
        <property type="gene ID" value="ENSPANG00000014185.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064222"/>
    <dbReference type="HOGENOM" id="CLU_418530_0_0_1"/>
    <dbReference type="OMA" id="MKNSNRY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014185">
        <property type="expression patterns" value="Expressed in bone marrow and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd22176">
        <property type="entry name" value="F-box_FBXO34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039594">
        <property type="entry name" value="FBXO34/46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16271:SF11">
        <property type="entry name" value="F-BOX ONLY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16271">
        <property type="entry name" value="F-BOX ONLY PROTEIN 34/46 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="604"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007789.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="743" mass="82517" checksum="78E8DFB4E5512FE5" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N786</accession>
    <name>A0A096N786_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Zinc finger with KRAB and SCAN domains 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZKSCAN7</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894622.1">
        <property type="nucleotide sequence ID" value="XM_003894573.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003894623.1">
        <property type="nucleotide sequence ID" value="XM_003894574.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N786"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008381"/>
    <dbReference type="Ensembl" id="ENSPANT00000016750.3">
        <property type="protein sequence ID" value="ENSPANP00000008381.1"/>
        <property type="gene ID" value="ENSPANG00000021914.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021560"/>
    <dbReference type="KEGG" id="panu:101021560"/>
    <dbReference type="CTD" id="55888"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162985"/>
    <dbReference type="HOGENOM" id="CLU_002678_49_8_1"/>
    <dbReference type="OMA" id="GHSGQCA"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021914">
        <property type="expression patterns" value="Expressed in testis and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N786">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009891">
        <property type="term" value="P:positive regulation of biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000666">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000002">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000822">
        <property type="entry name" value="Zinc finger protein 234, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001882">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000459">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000537">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF75">
        <property type="entry name" value="ZFP14 ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="17">
        <location>
            <begin position="54"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="18">
        <location>
            <begin position="224"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
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    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031509640.1">
        <property type="nucleotide sequence ID" value="XM_031653780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031509641.1">
        <property type="nucleotide sequence ID" value="XM_031653781.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031509642.1">
        <property type="nucleotide sequence ID" value="XM_031653782.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031509643.1">
        <property type="nucleotide sequence ID" value="XM_031653783.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031509644.1">
        <property type="nucleotide sequence ID" value="XM_031653784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N7K1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008539"/>
    <dbReference type="Ensembl" id="ENSPANT00000014714.3">
        <property type="protein sequence ID" value="ENSPANP00000008539.3"/>
        <property type="gene ID" value="ENSPANG00000020294.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100999879"/>
    <dbReference type="KEGG" id="panu:100999879"/>
    <dbReference type="CTD" id="1374"/>
    <dbReference type="GeneTree" id="ENSGT01150000286917"/>
    <dbReference type="HOGENOM" id="CLU_013513_2_1_1"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020294">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N7K1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006853">
        <property type="term" value="P:carnitine shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001676">
        <property type="term" value="P:long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000002">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF74">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="19">
        <location>
            <begin position="174"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008539.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="773" mass="88308" checksum="CDD1E5F2A864E735" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8Z7</accession>
    <name>A0A096N8Z7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,4-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">INPP4B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="3"/>
    <dbReference type="RefSeq" id="XP_017814559.1">
        <property type="nucleotide sequence ID" value="XM_017959070.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017814560.1">
        <property type="nucleotide sequence ID" value="XM_017959071.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017814561.1">
        <property type="nucleotide sequence ID" value="XM_017959072.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017814562.1">
        <property type="nucleotide sequence ID" value="XM_017959073.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017814564.1">
        <property type="nucleotide sequence ID" value="XM_017959075.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017814565.1">
        <property type="nucleotide sequence ID" value="XM_017959076.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8Z7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009078"/>
    <dbReference type="Ensembl" id="ENSPANT00000020867.3">
        <property type="protein sequence ID" value="ENSPANP00000009078.2"/>
        <property type="gene ID" value="ENSPANG00000009842.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101007295"/>
    <dbReference type="KEGG" id="panu:101007295"/>
    <dbReference type="CTD" id="8821"/>
    <dbReference type="eggNOG" id="KOG4428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157587"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009842">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N8Z7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000143">
        <property type="entry name" value="Type II inositol 3,4-bisphosphate 4-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF3">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="909"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009078.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="938" mass="106000" checksum="56DD59AA1C4D4C90" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NH48</accession>
    <name>A0A096NH48_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CKLF like MARVEL transmembrane domain containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CMTM6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003895269.1">
        <property type="nucleotide sequence ID" value="XM_003895220.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NH48"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012296"/>
    <dbReference type="Ensembl" id="ENSPANT00000011999.3">
        <property type="protein sequence ID" value="ENSPANP00000012296.1"/>
        <property type="gene ID" value="ENSPANG00000016560.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999534"/>
    <dbReference type="KEGG" id="panu:100999534"/>
    <dbReference type="CTD" id="54918"/>
    <dbReference type="eggNOG" id="KOG4788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157911"/>
    <dbReference type="HOGENOM" id="CLU_104458_1_0_1"/>
    <dbReference type="OMA" id="ASMVWEK"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016560">
        <property type="expression patterns" value="Expressed in thyroid gland and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NH48">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF25">
        <property type="entry name" value="CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="20357" checksum="E89035CBB5D24ECB" modified="2014-11-26" version="1">MENGAVYSPTTEEDPGPARGPRSGLAAYFFLDRLPGPRRVLKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFLASFMFLLDFAIMLYEKRQESQLRKPENTTRAEALTEPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIK5</accession>
    <name>A0A096NIK5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Peroxidasin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PXDN</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the peroxidase family. XPO subfamily.</text>
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        <property type="gene ID" value="ENSPANG00000011093.3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heme binding"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50184"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
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    </evidence>
    <sequence length="1522" mass="169635" checksum="70634608E29AF0AA" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLL4</accession>
    <name>A0A096NLL4_PAPAN</name>
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        <recommendedName>
            <fullName evidence="14">Phosphomannomutase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PMM2</name>
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    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 14">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="14"/>
    <dbReference type="RefSeq" id="XP_003916561.1">
        <property type="nucleotide sequence ID" value="XM_003916512.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009194222.1">
        <property type="nucleotide sequence ID" value="XM_009195958.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLL4"/>
    <dbReference type="SMR" id="A0A096NLL4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013872"/>
    <dbReference type="Ensembl" id="ENSPANT00000015917.4">
        <property type="protein sequence ID" value="ENSPANP00000013872.1"/>
        <property type="gene ID" value="ENSPANG00000026497.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101026429"/>
    <dbReference type="KEGG" id="panu:101026429"/>
    <dbReference type="CTD" id="5373"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002918"/>
    <dbReference type="HOGENOM" id="CLU_065642_0_0_1"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026497">
        <property type="expression patterns" value="Expressed in caecum and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLL4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061729">
        <property type="term" value="P:GDP-D-mannose biosynthetic process from fructose-6-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061728">
        <property type="term" value="P:GDP-mannose biosynthetic process from mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000216">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
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    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
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    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF2">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="246" mass="28038" checksum="373EE1C42C140611" modified="2014-11-26" version="1">MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYSVTAPEDTRRICEELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNZ7</accession>
    <name>A0A096NNZ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">LIAS</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="RefSeq" id="XP_003898642.1">
        <property type="nucleotide sequence ID" value="XM_003898593.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNZ7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014707"/>
    <dbReference type="Ensembl" id="ENSPANT00000017513.4">
        <property type="protein sequence ID" value="ENSPANP00000014707.1"/>
        <property type="gene ID" value="ENSPANG00000001640.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101004075"/>
    <dbReference type="KEGG" id="panu:101004075"/>
    <dbReference type="CTD" id="11019"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006234"/>
    <dbReference type="HOGENOM" id="CLU_033144_2_0_1"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001640">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NNZ7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="122"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="372" mass="41841" checksum="FB22EE1F69D157EB" modified="2014-11-26" version="1">MSLRCGDAARTLGPRVFGRYLCSPVRPLSSLPDEKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYSTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPD3</accession>
    <name>A0A096NPD3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SHQ1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Directly interacts with DKC1 alone, but not in the context of the core trimer composed of DKC1, NOP10 and NHP2, nor in the presence of NAF1. Does not interact with NAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894232.1">
        <property type="nucleotide sequence ID" value="XM_003894183.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NPD3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014862"/>
    <dbReference type="Ensembl" id="ENSPANT00000004997.3">
        <property type="protein sequence ID" value="ENSPANP00000014862.2"/>
        <property type="gene ID" value="ENSPANG00000002881.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002537"/>
    <dbReference type="KEGG" id="panu:101002537"/>
    <dbReference type="CTD" id="55164"/>
    <dbReference type="eggNOG" id="KOG3247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007605"/>
    <dbReference type="HOGENOM" id="CLU_030217_0_0_1"/>
    <dbReference type="OMA" id="HNIESAW"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002881">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NPD3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060765">
        <property type="term" value="P:regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000022">
        <property type="entry name" value="Protein SHQ1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014862.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="577" mass="65242" checksum="9620A8DEC6A47447" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ40</accession>
    <name>A0A096NQ40_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Neurexin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Neurexin II-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Neurexin-2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">NRXN2</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031508600.1">
        <property type="nucleotide sequence ID" value="XM_031652740.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000015134"/>
    <dbReference type="Ensembl" id="ENSPANT00000012842.3">
        <property type="protein sequence ID" value="ENSPANP00000015134.3"/>
        <property type="gene ID" value="ENSPANG00000004471.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100137468"/>
    <dbReference type="CTD" id="9379"/>
    <dbReference type="eggNOG" id="KOG3514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155978"/>
    <dbReference type="OMA" id="XHAGIGH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004471">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 41 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQ40">
        <property type="expression patterns" value="baseline"/>
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        <source>
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    <sequence length="1713" mass="185104" checksum="5A38AED71FC765ED" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQI3</accession>
    <name>A0A096NQI3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">E3 ubiquitin-protein ligase TRIM35</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">RING-type E3 ubiquitin transferase TRIM5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">TRIM5alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Tripartite motif-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">TRIM35</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="26">Interacts with PKM isoform M2, but not isoform M1; this interaction may compete with that between PKM and FGFR1, and hence reduces FGFR1-dependent tyrosine phosphorylation of PKM. Interacts with IRF7; this interaction promotes IRF7 proteasomal degradation. Interacts with TRAF3; this interaction promotes TRAF3 activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003902627.1">
        <property type="nucleotide sequence ID" value="XM_003902578.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQI3"/>
    <dbReference type="SMR" id="A0A096NQI3"/>
    <dbReference type="Ensembl" id="ENSPANT00000005251.3">
        <property type="protein sequence ID" value="ENSPANP00000015287.1"/>
        <property type="gene ID" value="ENSPANG00000017759.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023536"/>
    <dbReference type="KEGG" id="panu:101023536"/>
    <dbReference type="CTD" id="23087"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160868"/>
    <dbReference type="HOGENOM" id="CLU_013137_0_3_1"/>
    <dbReference type="OMA" id="CYDPFRE"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017759">
        <property type="expression patterns" value="Expressed in esophagus and 51 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQI3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044790">
        <property type="term" value="P:suppression of viral release by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16599">
        <property type="entry name" value="RING-HC_TRIM35_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12893">
        <property type="entry name" value="SPRY_PRY_TRIM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000036">
        <property type="entry name" value="Tripartite motif-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001525">
        <property type="entry name" value="Tripartite motif-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000373">
        <property type="entry name" value="Tripartite motif-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="20 29" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 28" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="30">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="31">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="32">
        <location>
            <begin position="284"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00033283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00059140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00065817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00073063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="493" mass="56554" checksum="BFB7E5BFD3AD6CBD" modified="2014-11-26" version="1">MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIERLQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRICPLHISIKEELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUD8</accession>
    <name>A0A096NUD8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Filamin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FLNC</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the filamin family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000016662.3"/>
        <property type="gene ID" value="ENSPANG00000025046.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153588"/>
    <dbReference type="HOGENOM" id="CLU_000783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025046">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 35 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUD8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21310">
        <property type="entry name" value="CH_FLNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21314">
        <property type="entry name" value="CH_FLNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000042">
        <property type="entry name" value="Filamin-B isoform B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000092">
        <property type="entry name" value="Filamin-B isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000008">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000007">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000079">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000125">
        <property type="entry name" value="filamin-B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000138">
        <property type="entry name" value="filamin-B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000154">
        <property type="entry name" value="filamin-B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000102">
        <property type="entry name" value="filamin-B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000105">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000115">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000126">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000157">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000118">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000122">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000168">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF12">
        <property type="entry name" value="FILAMIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="36"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="370"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="469"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="566"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="662"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="759"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="862"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1438"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1534"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1643"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1752"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1821"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1911"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2003"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2188"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2276"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2370"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2467"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
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            <begin position="2597"/>
            <end position="2691"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2206"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2206"/>
            <end position="2225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016662.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2692" mass="287285" checksum="189BEC2282A5B0FB" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUW5</accession>
    <name>A0A096NUW5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BPI fold-containing family B member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ligand-binding protein RYA3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Long palate, lung and nasal epithelium carcinoma-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BPIFB3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NUW5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016840"/>
    <dbReference type="Ensembl" id="ENSPANT00000011777.3">
        <property type="protein sequence ID" value="ENSPANP00000016840.3"/>
        <property type="gene ID" value="ENSPANG00000020552.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="HOGENOM" id="CLU_031635_1_0_1"/>
    <dbReference type="OMA" id="EWLSHVV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020552">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000004">
        <property type="entry name" value="BPI fold-containing family B member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000003">
        <property type="entry name" value="BPI fold-containing family B member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051660">
        <property type="entry name" value="BPI_fold-BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019:SF5">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035216662" description="BPI fold-containing family B member 3" evidence="11">
        <location>
            <begin position="24"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="13">
        <location>
            <begin position="274"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016840.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="476" mass="50336" checksum="C2EC8047A1B866E9" modified="2022-05-25" version="3">VQPAMLGLWSLLLLWGLATPCQGLLETVGTFARIDKDELGKAIQNSLVGGPILQNVLGSVTAVNQGLLGSGGLLGGGGLLGHGGVFGVVEELSGLKIEELTLPKELLKLLPGFGVQLNLHTKVGMHCSGPLGGLLQLAAEVNVTSRVALGVSSRGTPILILKRCSTLLGHISLFSGLLPTPLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGAVLGLVPLGALGSLEFSLATLPLISNQYIELDINPIVKSVAGDIIDFPKSPAPAKVPPKEDHTSQVTVPLYLFNTMFGLLQTNGALDMDITPELVPSDVPLTTTDLVALLPEALGKLPLHQHLLLSLRVKEAPTVTLNNKKALVSLPANIHVLFYVPQGTPESLFELNSVMTLRAQLTPSATKLHISLCLERLSVKVASSFTYAFDESRLEEWLSHVVRVVYAPKLNVALDVGIPLPKVLNISFSSSVLEIIENAVVLTVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUX1</accession>
    <name>A0A096NUX1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein on Y chromosome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EFCAB8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009214592.1">
        <property type="nucleotide sequence ID" value="XM_009216328.4"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000016846"/>
    <dbReference type="Ensembl" id="ENSPANT00000013617.3">
        <property type="protein sequence ID" value="ENSPANP00000016846.2"/>
        <property type="gene ID" value="ENSPANG00000023852.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010508"/>
    <dbReference type="KEGG" id="panu:101010508"/>
    <dbReference type="CTD" id="388795"/>
    <dbReference type="eggNOG" id="ENOG502S3DN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163617"/>
    <dbReference type="HOGENOM" id="CLU_697466_0_0_1"/>
    <dbReference type="OMA" id="MQPGKIH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023852">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF6">
        <property type="entry name" value="EF-HAND CALCIUM BINDING DOMAIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="948"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016846.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1288" mass="146056" checksum="40715EEE263544C1" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVG4</accession>
    <name>A0A096NVG4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protein phosphatase 1A</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein phosphatase 2C isoform alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Protein phosphatase IA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">PPM1A</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 29">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 25">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="RefSeq" id="XP_009209915.1">
        <property type="nucleotide sequence ID" value="XM_009211651.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209916.1">
        <property type="nucleotide sequence ID" value="XM_009211652.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209917.1">
        <property type="nucleotide sequence ID" value="XM_009211653.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209924.1">
        <property type="nucleotide sequence ID" value="XM_009211660.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796968.1">
        <property type="nucleotide sequence ID" value="XM_021941276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NVG4"/>
    <dbReference type="SMR" id="A0A096NVG4"/>
    <dbReference type="Ensembl" id="ENSPANT00000015718.3">
        <property type="protein sequence ID" value="ENSPANP00000017039.3"/>
        <property type="gene ID" value="ENSPANG00000007522.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023753"/>
    <dbReference type="CTD" id="5494"/>
    <dbReference type="eggNOG" id="KOG0697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154832"/>
    <dbReference type="HOGENOM" id="CLU_013173_4_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007522">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NVG4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901223">
        <property type="term" value="P:negative regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.430:FF:000002">
        <property type="entry name" value="Protein phosphatase, Mg2+/Mn2+ dependent 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.430">
        <property type="entry name" value="Phosphatase 2C, C-terminal domain suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036580">
        <property type="entry name" value="PP2C_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81601">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0519">Myristate</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 25" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="26">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017039.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="382" mass="42448" checksum="D48EF508B4A76687" modified="2022-05-25" version="3">MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVI8</accession>
    <name>A0A096NVI8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">JAG1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Membrane</location>
            <topology evidence="2 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021776921.2">
        <property type="nucleotide sequence ID" value="XM_021921229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NVI8"/>
    <dbReference type="SMR" id="A0A096NVI8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017063"/>
    <dbReference type="Ensembl" id="ENSPANT00000015583.3">
        <property type="protein sequence ID" value="ENSPANP00000017063.3"/>
        <property type="gene ID" value="ENSPANG00000004885.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005762"/>
    <dbReference type="KEGG" id="panu:101005762"/>
    <dbReference type="CTD" id="182"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160148"/>
    <dbReference type="HOGENOM" id="CLU_004732_0_0_1"/>
    <dbReference type="OMA" id="CHPVHGH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004885">
        <property type="expression patterns" value="Expressed in zone of skin and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NVI8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035909">
        <property type="term" value="P:aorta morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061309">
        <property type="term" value="P:cardiac neural crest cell development involved in outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003215">
        <property type="term" value="P:cardiac right ventricle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060411">
        <property type="term" value="P:cardiac septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061073">
        <property type="term" value="P:ciliary body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072017">
        <property type="term" value="P:distal tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061444">
        <property type="term" value="P:endocardial cushion cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002085">
        <property type="term" value="P:inhibition of neuroepithelial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042491">
        <property type="term" value="P:inner ear auditory receptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072070">
        <property type="term" value="P:loop of Henle development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002011">
        <property type="term" value="P:morphogenesis of an epithelial sheet"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of cell-matrix adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045602">
        <property type="term" value="P:negative regulation of endothelial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000737">
        <property type="term" value="P:negative regulation of stem cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061101">
        <property type="term" value="P:neuroendocrine cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072015">
        <property type="term" value="P:podocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045639">
        <property type="term" value="P:positive regulation of myeloid cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003184">
        <property type="term" value="P:pulmonary valve morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032495">
        <property type="term" value="P:response to muramyl dipeptide"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002456">
        <property type="term" value="P:T cell mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000007">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000148">
        <property type="entry name" value="Delta-like protein"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000181">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000229">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000473">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
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    </dbReference>
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        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Putative neurogenic locus notch"/>
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    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
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    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
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    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
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    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
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    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
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        <property type="entry name" value="Jagged/Serrate"/>
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    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
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    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF12">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
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    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGFBLOOD"/>
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    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
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        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 17" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13 15 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 17 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035167330" description="Delta-like protein" evidence="20">
        <location>
            <begin position="31"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1068"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="22">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="586"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="629"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="667"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
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            <end position="741"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
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            <end position="780"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="820"/>
            <end position="856"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1152"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
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    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="200"/>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="220"/>
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        <location>
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    </feature>
    <feature type="disulfide bond" evidence="15">
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    </feature>
    <feature type="disulfide bond" evidence="15">
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="454"/>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="475"/>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="513"/>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="551"/>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="617"/>
            <end position="626"/>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="655"/>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="693"/>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="731"/>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="770"/>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="808"/>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="846"/>
            <end position="855"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017063.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133809" checksum="330552E79D22DBB5" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NW13</accession>
    <name>A0A096NW13_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LanC-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Testis-specific adriamycin sensitivity protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LANCL2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896011.1">
        <property type="nucleotide sequence ID" value="XM_003895962.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NW13"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017238"/>
    <dbReference type="Ensembl" id="ENSPANT00000014404.3">
        <property type="protein sequence ID" value="ENSPANP00000017238.1"/>
        <property type="gene ID" value="ENSPANG00000016955.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003233"/>
    <dbReference type="KEGG" id="panu:101003233"/>
    <dbReference type="CTD" id="55915"/>
    <dbReference type="eggNOG" id="KOG2787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063186"/>
    <dbReference type="HOGENOM" id="CLU_036244_0_0_1"/>
    <dbReference type="OMA" id="LSLYFEW"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016955">
        <property type="expression patterns" value="Expressed in Ammon's horn and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009789">
        <property type="term" value="P:positive regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000022">
        <property type="entry name" value="LanC like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF11">
        <property type="entry name" value="LANC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="450" mass="50834" checksum="4A776A23BFE9ECD9" modified="2014-11-26" version="1">MGETMSKRLKLHLGGEAEMEERAFANPFPDYETATGALLAAGAAEETGCVRPPATTDEPGLPFHQDGKIIHNLIRRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDCESQECITKLLQLQRAVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQAYKVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYRLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAIHFLSDVLGPETSRFPAFELDSSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NX25</accession>
    <name>A0A096NX25_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cap-specific adenosine methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylated CTD-interacting factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PCIF1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with POLR2A; interacts with the phosphorylated C-terminal domain (CTD) of POLR2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAPAM family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.62" evidence="8"/>
    <dbReference type="RefSeq" id="XP_003904716.1">
        <property type="nucleotide sequence ID" value="XM_003904667.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NX25"/>
    <dbReference type="Ensembl" id="ENSPANT00000007257.3">
        <property type="protein sequence ID" value="ENSPANP00000017615.1"/>
        <property type="gene ID" value="ENSPANG00000024782.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004581"/>
    <dbReference type="KEGG" id="panu:101004581"/>
    <dbReference type="CTD" id="63935"/>
    <dbReference type="eggNOG" id="ENOG502QVT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016206"/>
    <dbReference type="HOGENOM" id="CLU_014369_0_0_1"/>
    <dbReference type="OMA" id="ANENHRS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024782">
        <property type="expression patterns" value="Expressed in aorta and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000020">
        <property type="entry name" value="Phosphorylated CTD-interacting factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000036">
        <property type="entry name" value="Phosphorylated CTD-interacting factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="664"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="704" mass="80660" checksum="F64279859C0F0FF3" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZD4</accession>
    <name>A0A096NZD4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase 32B</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">STK32B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003898511.1">
        <property type="nucleotide sequence ID" value="XM_003898462.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZD4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018455"/>
    <dbReference type="Ensembl" id="ENSPANT00000013115.3">
        <property type="protein sequence ID" value="ENSPANP00000018455.1"/>
        <property type="gene ID" value="ENSPANG00000019894.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025472"/>
    <dbReference type="KEGG" id="panu:101025472"/>
    <dbReference type="CTD" id="55351"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160490"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="QKCVERD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019894">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZD4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000158">
        <property type="entry name" value="Serine/threonine-protein kinase 32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000676">
        <property type="entry name" value="serine/threonine-protein kinase 32B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000735">
        <property type="entry name" value="serine/threonine-protein kinase 32B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000160">
        <property type="entry name" value="Serine/threonine-protein kinase 32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="414" mass="47802" checksum="D919F15A9A0F5ACD" modified="2014-11-26" version="1">MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDGGPGYSYPVDWWSLGVTAYELLRGWRPYEIHSATPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRLSSLRDIQSVPYLADMNWDVVFEKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDSTKDSCPLNGHLQQCLETVRKEFIIFNREKLRRQQGQGSQLLDTDSRAGGQAQSKLQDGCNNNLLTTTCTRGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZE2</accession>
    <name>A0A096NZE2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small RNA binding exonuclease protection factor La</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SSB</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096NZE2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018463"/>
    <dbReference type="Ensembl" id="ENSPANT00000009122.4">
        <property type="protein sequence ID" value="ENSPANP00000018463.3"/>
        <property type="gene ID" value="ENSPANG00000007440.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00830000128380"/>
    <dbReference type="OMA" id="ICHEIEY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007440">
        <property type="expression patterns" value="Expressed in axillary lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZE2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075522">
        <property type="term" value="P:IRES-dependent viral translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071045">
        <property type="term" value="P:nuclear histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903608">
        <property type="term" value="P:protein localization to cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12541">
        <property type="entry name" value="RRM2_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000402">
        <property type="entry name" value="Lupus La protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRRM" evidence="5">
        <location>
            <begin position="145"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018463.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="312" mass="35714" checksum="5D0837DFECAD9AFE" modified="2022-05-25" version="3">MLIWEILQIATMAENGDNEKMAALEAKICHQIEKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPDQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDENGATGKFFPKSFGSFMRKFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZT5</accession>
    <name>A0A096NZT5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Macrophage-capping protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Actin regulatory protein CAP-G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CAPG</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Interacts with NUP62. Interacts with NUTF2 and RAN; involved in CAPG nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NZT5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018610"/>
    <dbReference type="Ensembl" id="ENSPANT00000028987.3">
        <property type="protein sequence ID" value="ENSPANP00000018610.2"/>
        <property type="gene ID" value="ENSPANG00000000842.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159305"/>
    <dbReference type="HOGENOM" id="CLU_002568_0_0_1"/>
    <dbReference type="OMA" id="HDMTLAK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000842">
        <property type="expression patterns" value="Expressed in esophagus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000078">
        <property type="entry name" value="Macrophage-capping protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000040">
        <property type="entry name" value="macrophage-capping protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000037">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF127">
        <property type="entry name" value="MACROPHAGE-CAPPING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="19">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="19">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="19">
        <location>
            <begin position="365"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018610.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="446" mass="49400" checksum="56954344D9F67491" modified="2022-05-25" version="2">MWTSSLPVGPSEETAWHTHCPPQCLLFCFRPTGLPALPAPPCRGTWPPHRLGKEPRGGAGGWGRQRSKREVRSWVGQAGRKTNLPSRSRSKKGRSEDSMYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVARENQGIFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYALNTQVEILPQGRESPIFKQFFKDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2F6</accession>
    <name>A0A096P2F6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPNS3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912173.2">
        <property type="nucleotide sequence ID" value="XM_003912124.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2F6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019531"/>
    <dbReference type="Ensembl" id="ENSPANT00000023766.3">
        <property type="protein sequence ID" value="ENSPANP00000019531.2"/>
        <property type="gene ID" value="ENSPANG00000024351.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012219"/>
    <dbReference type="KEGG" id="panu:101012219"/>
    <dbReference type="CTD" id="201305"/>
    <dbReference type="eggNOG" id="KOG1330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005976"/>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_1"/>
    <dbReference type="OMA" id="YTCVYTA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024351">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF3">
        <property type="entry name" value="PROTEIN SPINSTER HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="512" mass="54722" checksum="800C52CFE7FAF6FC" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P387</accession>
    <name>A0A096P387_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox protein SEBOX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Homeobox OG-9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Skin-, embryo-, brain- and oocyte-specific homeobox</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SEBOX</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Probable transcription factor involved in the control of specification of mesoderm and endoderm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P387"/>
    <dbReference type="Ensembl" id="ENSPANT00000021963.3">
        <property type="protein sequence ID" value="ENSPANP00000019812.2"/>
        <property type="gene ID" value="ENSPANG00000023513.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00920000149180"/>
    <dbReference type="HOGENOM" id="CLU_080455_0_0_1"/>
    <dbReference type="OMA" id="AFAAWPY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023513">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000312">
        <property type="entry name" value="Mix-type homeobox gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042223">
        <property type="entry name" value="SEBOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47777">
        <property type="entry name" value="HOMEOBOX PROTEIN SEBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47777:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN SEBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019812.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="190" mass="20455" checksum="3D1968FA72F8223B" modified="2018-02-28" version="2">MGSPVDASSADGGSGLGSHQRKRTTFSKGQLLELERAFAAWPYPDISTREHLAQVTRLPEAKIQVWFQNRRAKRIKNRKSRSLSPRPESHQSSCSLPDTFQQPWDPQIPGQPPLSSGTPQCTSVCQYTSCPAPGLSPGQGWEGAKAVAPRGPGGASQVHPFLERATPQTSLGSLSDLIYALATVTNVDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4B0</accession>
    <name>A0A096P4B0_PAPAN</name>
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        <submittedName>
            <fullName evidence="7">WDFY family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WDFY4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003903633.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212665.2">
        <property type="nucleotide sequence ID" value="XM_009214401.3"/>
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    <dbReference type="RefSeq" id="XP_009212667.2">
        <property type="nucleotide sequence ID" value="XM_009214403.3"/>
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    <dbReference type="RefSeq" id="XP_009212669.2">
        <property type="nucleotide sequence ID" value="XM_009214405.3"/>
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    <dbReference type="RefSeq" id="XP_009212670.2">
        <property type="nucleotide sequence ID" value="XM_009214406.3"/>
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    <dbReference type="RefSeq" id="XP_009212671.2">
        <property type="nucleotide sequence ID" value="XM_009214407.4"/>
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    <dbReference type="RefSeq" id="XP_009212672.2">
        <property type="nucleotide sequence ID" value="XM_009214408.4"/>
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    <dbReference type="RefSeq" id="XP_021798956.2">
        <property type="nucleotide sequence ID" value="XM_021943264.2"/>
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    <dbReference type="RefSeq" id="XP_031508206.1">
        <property type="nucleotide sequence ID" value="XM_031652346.1"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000020185"/>
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        <property type="protein sequence ID" value="ENSPANP00000020185.3"/>
        <property type="gene ID" value="ENSPANG00000022623.4"/>
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    <dbReference type="GeneID" id="101018114"/>
    <dbReference type="KEGG" id="panu:101018114"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155684"/>
    <dbReference type="HOGENOM" id="CLU_000175_5_2_1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
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    <dbReference type="Bgee" id="ENSPANG00000022623">
        <property type="expression patterns" value="Expressed in bone marrow and 23 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0036037">
        <property type="term" value="P:CD8-positive, alpha-beta T cell activation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="BEACH_dom"/>
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    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
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    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
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    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4"/>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="2383"/>
            <end position="2508"/>
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    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2525"/>
            <end position="2819"/>
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        <location>
            <begin position="2976"/>
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        <location>
            <begin position="3082"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
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            <begin position="1835"/>
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            <begin position="2309"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3105"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1839"/>
            <end position="1848"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50197"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020185.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="3182" mass="353528" checksum="609D943A7C2C630B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4L3</accession>
    <name>A0A096P4L3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luc7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LUC7L3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds cAMP regulatory element DNA sequence. Plays a role in RNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May interact with SFRS1 and form homodimers. Interacts with JMJD6. Interacts with RBM25. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with RRP1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912793.1">
        <property type="nucleotide sequence ID" value="XM_003912744.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009188504.1">
        <property type="nucleotide sequence ID" value="XM_009190240.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P4L3"/>
    <dbReference type="SMR" id="A0A096P4L3"/>
    <dbReference type="Ensembl" id="ENSPANT00000018573.4">
        <property type="protein sequence ID" value="ENSPANP00000020288.3"/>
        <property type="gene ID" value="ENSPANG00000022461.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101011509"/>
    <dbReference type="KEGG" id="panu:101011509"/>
    <dbReference type="CTD" id="51747"/>
    <dbReference type="GeneTree" id="ENSGT00950000183213"/>
    <dbReference type="HOGENOM" id="CLU_030397_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022461">
        <property type="expression patterns" value="Expressed in olfactory bulb and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P4L3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020288.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="432" mass="51466" checksum="E75F55EC0137310C" modified="2022-05-25" version="3">MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4N0</accession>
    <name>A0A096P4N0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">USP54</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003903815.2">
        <property type="nucleotide sequence ID" value="XM_003903766.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212940.2">
        <property type="nucleotide sequence ID" value="XM_009214676.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212941.2">
        <property type="nucleotide sequence ID" value="XM_009214677.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212942.2">
        <property type="nucleotide sequence ID" value="XM_009214678.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212943.2">
        <property type="nucleotide sequence ID" value="XM_009214679.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212944.2">
        <property type="nucleotide sequence ID" value="XM_009214680.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212945.2">
        <property type="nucleotide sequence ID" value="XM_009214681.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212948.2">
        <property type="nucleotide sequence ID" value="XM_009214684.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212949.2">
        <property type="nucleotide sequence ID" value="XM_009214685.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009212950.2">
        <property type="nucleotide sequence ID" value="XM_009214686.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017818425.2">
        <property type="nucleotide sequence ID" value="XM_017962936.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021799054.2">
        <property type="nucleotide sequence ID" value="XM_021943362.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021799055.2">
        <property type="nucleotide sequence ID" value="XM_021943363.2"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000020305"/>
    <dbReference type="Ensembl" id="ENSPANT00000018322.3">
        <property type="protein sequence ID" value="ENSPANP00000020305.3"/>
        <property type="gene ID" value="ENSPANG00000022376.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024594"/>
    <dbReference type="KEGG" id="panu:101024594"/>
    <dbReference type="CTD" id="159195"/>
    <dbReference type="eggNOG" id="KOG1887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155571"/>
    <dbReference type="HOGENOM" id="CLU_004234_0_0_1"/>
    <dbReference type="OMA" id="YGAENFH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022376">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P4N0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000041">
        <property type="entry name" value="Inactive ubiquitin carboxyl-terminal hydrolase 53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
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        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
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        <property type="entry name" value="INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 54"/>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
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    <sequence length="1685" mass="187240" checksum="40D87F0F8853BFD5" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4Y3</accession>
    <name>A0A096P4Y3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="16">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">BRCA1-associated C-terminal helicase 1</fullName>
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        <alternativeName>
            <fullName evidence="18">BRCA1-interacting protein C-terminal helicase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA 5'-3' helicase FANCJ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BRIP1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
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        <property type="gene ID" value="ENSPANG00000022169.3"/>
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        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Bgee" id="ENSPANG00000022169">
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        <property type="term" value="C:BRCA1-B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="11"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1022"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1109"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1109"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020408.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1247" mass="140585" checksum="25B801FD089058F6" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUI4</accession>
    <name>A0A0A0MUI4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein 30 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZFP30</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915497.1">
        <property type="nucleotide sequence ID" value="XM_003915448.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017808395.1">
        <property type="nucleotide sequence ID" value="XM_017952906.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017808397.1">
        <property type="nucleotide sequence ID" value="XM_017952908.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUI4"/>
    <dbReference type="Ensembl" id="ENSPANT00000004860.3">
        <property type="protein sequence ID" value="ENSPANP00000001587.3"/>
        <property type="gene ID" value="ENSPANG00000011871.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013441"/>
    <dbReference type="KEGG" id="panu:101013441"/>
    <dbReference type="CTD" id="22835"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162363"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_17_1"/>
    <dbReference type="OMA" id="YQRIHNR"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019660">
        <property type="expression patterns" value="Expressed in axillary lymph node and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MUI4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000020">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000473">
        <property type="entry name" value="zinc finger protein 14 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000434">
        <property type="entry name" value="zinc finger protein 30 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000561">
        <property type="entry name" value="Zinc finger protein 30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF435">
        <property type="entry name" value="ZINC FINGER PROTEIN 59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="18">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001587.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="519" mass="61457" checksum="879E0BC57C417C9B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVR9</accession>
    <name>A0A0A0MVR9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">XPA-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">XAB2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVR9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007476"/>
    <dbReference type="Ensembl" id="ENSPANT00000016533.3">
        <property type="protein sequence ID" value="ENSPANP00000007476.2"/>
        <property type="gene ID" value="ENSPANG00000023955.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075140"/>
    <dbReference type="HOGENOM" id="CLU_007736_2_1_1"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023955">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001824">
        <property type="term" value="P:blastocyst development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000411">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000519">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001071">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="18" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="22">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="20">
        <location>
            <begin position="181"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="21">
        <location>
            <begin position="387"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="810"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <accession>A0A0A0MWP8</accession>
    <name>A0A0A0MWP8_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">Centrosomal protein 89</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">CEP89</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 20"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:non-motile cilium assembly"/>
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        <location>
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            <begin position="173"/>
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        <location>
            <begin position="240"/>
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        <location>
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        <location>
            <begin position="34"/>
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    </feature>
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            <begin position="173"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010054.3"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LCN6</accession>
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        <recommendedName>
            <fullName evidence="2">Triadin</fullName>
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        <name evidence="14" type="primary">TRDN</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LCN6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000021206"/>
    <dbReference type="Ensembl" id="ENSPANT00000056346.2">
        <property type="protein sequence ID" value="ENSPANP00000021206.2"/>
        <property type="gene ID" value="ENSPANG00000033731.2"/>
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    <dbReference type="GeneTree" id="ENSGT00510000049207"/>
    <dbReference type="OMA" id="TQIHKQD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033731">
        <property type="expression patterns" value="Expressed in gastrocnemius and 44 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014701">
        <property type="term" value="C:junctional sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086036">
        <property type="term" value="P:regulation of cardiac muscle cell membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010880">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007943">
        <property type="entry name" value="Asp-B-hydro/Triadin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010798">
        <property type="entry name" value="Triadin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14106">
        <property type="entry name" value="TRIADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14106:SF0">
        <property type="entry name" value="TRIADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05279">
        <property type="entry name" value="Asp-B-Hydro_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl beta-hydroxylase/Triadin" evidence="13">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021206.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="725" mass="81202" checksum="557CA835E68833A0" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LF84</accession>
    <name>A0A2I3LF84_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">39S ribosomal protein L44, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MRPL44</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908061.1">
        <property type="nucleotide sequence ID" value="XM_003908012.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009181443.1">
        <property type="nucleotide sequence ID" value="XM_009183179.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LF84"/>
    <dbReference type="STRING" id="9555.ENSPANP00000022138"/>
    <dbReference type="Ensembl" id="ENSPANT00000041283.2">
        <property type="protein sequence ID" value="ENSPANP00000022138.1"/>
        <property type="gene ID" value="ENSPANG00000018302.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023441"/>
    <dbReference type="KEGG" id="panu:101023441"/>
    <dbReference type="CTD" id="65080"/>
    <dbReference type="GeneTree" id="ENSGT00390000016956"/>
    <dbReference type="OMA" id="ACYRVGL"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018302">
        <property type="expression patterns" value="Expressed in metanephros cortex and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LF84">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19874">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000010">
        <property type="entry name" value="39S ribosomal protein L44, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000037">
        <property type="entry name" value="39S ribosomal protein L44, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNase III" evidence="16">
        <location>
            <begin position="68"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="15">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="332" mass="37479" checksum="514CE13AB695F260" modified="2018-02-28" version="1">MASGLVRVLQQGPRCLLAPVVPKLVPPVRGVKKGFRAAFRFQKELERLRLLRCPPPPVRRSEKPNWDYHAEIQAFGHRLQENFSLDLLKTAFVNSCYIKSEEAKRQQLGIEKEAVLLNLKSNQELSEQGTSFSQTCLTQFLEDEFPDLPTEGIRNLVAFLTGEEVVCHVARNLAVEQLTLSEEFPVPSTVLQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIIDPMGLLVEELKKRNISAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYGFTENRRPWNYSKPKETLRAEKSITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M398</accession>
    <name>A0A2I3M398_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M398"/>
    <dbReference type="Ensembl" id="ENSPANT00000042515.2">
        <property type="protein sequence ID" value="ENSPANP00000030173.2"/>
        <property type="gene ID" value="ENSPANG00000034101.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000290142"/>
    <dbReference type="OMA" id="SELACKY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031242">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030173.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="52" mass="6167" checksum="1C649C4F531EAFE2" modified="2022-05-25" version="2">MASVSQLTCIYLALIPHDDEVTLRRRKWKPRKKNPRSLMMTWALVFLTKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7I3</accession>
    <name>A0A2I3M7I3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tropomyosin 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M7I3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031701"/>
    <dbReference type="Ensembl" id="ENSPANT00000056777.2">
        <property type="protein sequence ID" value="ENSPANP00000031701.2"/>
        <property type="gene ID" value="ENSPANG00000031792.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234542"/>
    <dbReference type="OMA" id="MQHVEND"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031792">
        <property type="expression patterns" value="Expressed in testis and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000004">
        <property type="entry name" value="tropomyosin alpha-1 chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031701.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27211" checksum="901E78B7C806EAF5" modified="2022-05-25" version="2">MAKTLSISTLHLKLLTFSLISHILFPFIYYISRGLDLDRERERREKAEGDGAALNRRTQLVEEESDRAQERLATALQKLEEAEKAADESERNEGDRNRAMKDEEKMEIQELQLKEAKHTAEEADRRHEEVARKLVILEGELERAEERAENVTNNPKSLEAASEEYSEKEDKYEEEIKLLSDKLKEAETRAEFADRMVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MB60</accession>
    <name>A0A2I3MB60_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Complement component 4 binding protein beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">C4BPB</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009186662.1">
        <property type="nucleotide sequence ID" value="XM_009188398.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MB60"/>
    <dbReference type="Ensembl" id="ENSPANT00000033978.2">
        <property type="protein sequence ID" value="ENSPANP00000032982.2"/>
        <property type="gene ID" value="ENSPANG00000018149.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017897"/>
    <dbReference type="CTD" id="725"/>
    <dbReference type="GeneTree" id="ENSGT00940000163065"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018149">
        <property type="expression patterns" value="Expressed in liver and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MB60">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000090">
        <property type="entry name" value="Complement component 4 binding protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000098">
        <property type="entry name" value="Complement component 4 binding protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000104">
        <property type="entry name" value="Complement component 4 binding protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035232990" evidence="9">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032982.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="251" mass="28396" checksum="1D8E12BF4427A024" modified="2022-05-25" version="2">MFFWCACCLMVARWVSASDEHCPELPPVNNSIFIAKEVEGQILGTYVCIKGYHLVGKKTVFCNASKEWDNTTTECRLGHCPDPVLVNGEFSTSGPVNVSDKITFKCNDHYILKGSNWSQCLEDHTWAPPFPICKSRDCDPPGNPAHGYFKGDNFTLGSTISYYCKDRYYLVGMQEQQCIDGEWSSALPVCKLIQEAPKPECEKALLAFQERKDLCEAIENFMQQLKESGMTMEELKYSLELKKAELKAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MCR4</accession>
    <name>A0A2I3MCR4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM7 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translocase of outer membrane 7 kDa subunit homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MCR4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033577"/>
    <dbReference type="Ensembl" id="ENSPANT00000052130.2">
        <property type="protein sequence ID" value="ENSPANP00000033577.1"/>
        <property type="gene ID" value="ENSPANG00000008241.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014833"/>
    <dbReference type="OMA" id="MPEPTIM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008241">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MCR4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903955">
        <property type="term" value="P:positive regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46722">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46722:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="125" mass="14190" checksum="45C18028DD03FB19" modified="2018-02-28" version="1">MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFKRGADPGMPEPTVLRVWWLTPAVSALWKAKVGRSWEDCLRLGVQHQPGQHSETQLYQKKKTYFGDKGLIGLLDLEAISGQHGRCVLWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGR0</accession>
    <name>A0A2I3MGR0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AMP deaminase</fullName>
            <ecNumber evidence="10">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AMPD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003892386.1">
        <property type="nucleotide sequence ID" value="XM_003892337.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MGR0"/>
    <dbReference type="Ensembl" id="ENSPANT00000042514.2">
        <property type="protein sequence ID" value="ENSPANP00000034770.1"/>
        <property type="gene ID" value="ENSPANG00000014085.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011353"/>
    <dbReference type="KEGG" id="panu:101011353"/>
    <dbReference type="CTD" id="271"/>
    <dbReference type="GeneTree" id="ENSGT00950000183011"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014085">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MGR0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF3">
        <property type="entry name" value="AMP DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="798" mass="92061" checksum="60FD926306B819F0" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGZ7</accession>
    <name>A0A2I3MGZ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dynein axonemal heavy chain 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Axonemal beta dynein heavy chain 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ciliary dynein heavy chain 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DNAH2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">As part of the axonemal inner dynein arm complex plays a central role in ciliary beat. Expressed in sperm flagellum, it is required for sperm motility. Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Part of the axonemal inner dynein arm complex that consists of at least two heavy chains and a number of intermediate and light chains. Interacts with DNAI4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000034981"/>
    <dbReference type="Ensembl" id="ENSPANT00000053348.2">
        <property type="protein sequence ID" value="ENSPANP00000034981.2"/>
        <property type="gene ID" value="ENSPANG00000030477.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157623"/>
    <dbReference type="OMA" id="ILKNDMQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030477">
        <property type="expression patterns" value="Expressed in pancreas and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
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        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
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    <dbReference type="FunFam" id="1.20.140.100:FF:000006">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
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        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="23">
        <location>
            <begin position="1797"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="23">
        <location>
            <begin position="2408"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="3014"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="3220"/>
            <end position="3303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="3534"/>
            <end position="3561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034981.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="4427" mass="507855" checksum="D30CB7396ADAC6F1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MTY4</accession>
    <name>A0A2I3MTY4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCDC144C-like coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MTY4"/>
    <dbReference type="Ensembl" id="ENSPANT00000051240.2">
        <property type="protein sequence ID" value="ENSPANP00000039248.2"/>
        <property type="gene ID" value="ENSPANG00000034254.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162459"/>
    <dbReference type="OMA" id="IEQMYQI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034254">
        <property type="expression patterns" value="Expressed in testis and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040118">
        <property type="entry name" value="C144A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039497">
        <property type="entry name" value="CC144C-like_CC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021885">
        <property type="entry name" value="DUF3496"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22245">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22245:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14915">
        <property type="entry name" value="CCDC144C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12001">
        <property type="entry name" value="DUF3496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC144C-like coiled-coil" evidence="5">
        <location>
            <begin position="433"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3496" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="379"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="558"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="688"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="887"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039248.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="129855" checksum="930D6B92D8A159E3" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUM3</accession>
    <name>A0A2I3MUM3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium homeostasis modulator family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CALHM4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031523339.1">
        <property type="nucleotide sequence ID" value="XM_031667479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUM3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000039458"/>
    <dbReference type="Ensembl" id="ENSPANT00000056658.2">
        <property type="protein sequence ID" value="ENSPANP00000039458.1"/>
        <property type="gene ID" value="ENSPANG00000013290.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016906"/>
    <dbReference type="CTD" id="221301"/>
    <dbReference type="GeneTree" id="ENSGT01030000234610"/>
    <dbReference type="OMA" id="FRCPCQV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013290">
        <property type="expression patterns" value="Expressed in zone of skin and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF5">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="314" mass="35040" checksum="66E175483DDCBD8F" modified="2018-02-28" version="1">MCSTLNSIVSSLQRNGIFINSLIAALTVGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLIAGFALRSQMWTITGEYCCSCVPPYRRISPLECKLACLRFFSITGRAVVAPLTWLAVTLLTGTYYECAASEFASVDHYPIFDNVSASKREEILAGFPCCKSAPSDVILVRDDIALLHRYQSQMLGWILITLATIAVLVSCCVARCCSPLTSLQHCYWTSHLQNERQLFEQAAEQHSRLLIMHRIKQLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLRGHYSSLGNRVDEDNEEDRSRDIELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUY2</accession>
    <name>A0A2I3MUY2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS25</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45. Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and 2 copies of VPS25. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts (via C-terminal half) with the ESCRT-III subunit CHMP6 (via N-terminal half).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003913150.1">
        <property type="nucleotide sequence ID" value="XM_003913101.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUY2"/>
    <dbReference type="SMR" id="A0A2I3MUY2"/>
    <dbReference type="Ensembl" id="ENSPANT00000048256.2">
        <property type="protein sequence ID" value="ENSPANP00000039527.2"/>
        <property type="gene ID" value="ENSPANG00000021414.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011058"/>
    <dbReference type="KEGG" id="panu:101011058"/>
    <dbReference type="CTD" id="84313"/>
    <dbReference type="GeneTree" id="ENSGT00390000014892"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021414">
        <property type="expression patterns" value="Expressed in pancreas and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MUY2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000001">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039527.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="176" mass="20748" checksum="34963A53C3DA4DD5" modified="2022-05-25" version="2">MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MVP6</accession>
    <name>A0A2I3MVP6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Synergin gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">AP1 subunit gamma-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gamma-synergin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SYNRG</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Self-associates. Interacts with GGA1 (via GAE domain). Interacts with GGA2 and GGA3. Interacts with AP1G1 (via GAE domain), a subunit of adapter protein complex AP-1. Interacts with AP1G2 (via GAE domain) a subunit of adapter protein complex AP-1. Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated trafficking of transferrin from early to recycling endosomes. Within the complex interacts with AFTPH/aftiphilin and HEATR5B/p200a; the interactions are direct. Interacts (via EH domain) with SCAMP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000040444.2">
        <property type="protein sequence ID" value="ENSPANP00000039854.2"/>
        <property type="gene ID" value="ENSPANG00000022120.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010789"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022120">
        <property type="expression patterns" value="Expressed in thymus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MVP6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000075">
        <property type="entry name" value="synergin gamma isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039656">
        <property type="entry name" value="SYNRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059024">
        <property type="entry name" value="SYNRG_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463">
        <property type="entry name" value="AP1 GAMMA SUBUNIT BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463:SF2">
        <property type="entry name" value="SYNERGIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25999">
        <property type="entry name" value="SYNRG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EH" evidence="22">
        <location>
            <begin position="294"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="459"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="974"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1072"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00084050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039854.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1313" mass="140361" checksum="C4FF5EB7C35E293A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N274</accession>
    <name>A0A2I3N274_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N274"/>
    <dbReference type="STRING" id="9555.ENSPANP00000042093"/>
    <dbReference type="Ensembl" id="ENSPANT00000042120.2">
        <property type="protein sequence ID" value="ENSPANP00000042093.2"/>
        <property type="gene ID" value="ENSPANG00000030956.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038181"/>
    <dbReference type="OMA" id="MDPDGIW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030956">
        <property type="expression patterns" value="Expressed in duodenum and 34 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042093.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="155" mass="16925" checksum="48BEF8E0391F6DD3" modified="2025-10-08" version="3">MATAAAQGGRSSGSGGSSGAGGGSRCRTGSGHSGLLDKWKIDDKPVKIDKCDGLAVKTSLDDSAKKSIFVVTHRKDPTGMDPDGIWQLSSSLKRFDDKYTLKLTFTSWRTKQQREVEFTKGLIKFFDHSGTLVMDVYDPEISKLHDSLAIERKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N461</accession>
    <name>A0A2I3N461_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N461"/>
    <dbReference type="STRING" id="9555.ENSPANP00000042660"/>
    <dbReference type="Ensembl" id="ENSPANT00000049127.2">
        <property type="protein sequence ID" value="ENSPANP00000042660.2"/>
        <property type="gene ID" value="ENSPANG00000032588.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="OMA" id="MCVPEKQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032588">
        <property type="expression patterns" value="Expressed in bone marrow and 42 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101003">
        <property type="term" value="C:ficolin-1-rich granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070821">
        <property type="term" value="C:tertiary granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05712">
        <property type="entry name" value="IgV_CD33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002151">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000829">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF109">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="116"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="243"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="333"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042660.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="493" mass="54134" checksum="B0F157F535D7D5FB" modified="2022-05-25" version="2">MGPGDLRSLDLQVWTSPSGGLSIFTCGVQWGWEQDGLPAPASLRQHVMPKFSFCARPQLSLTLRLPVGASSAPPHIWGISFPDRGTWDPAGALADGDMLPLLLLPLLWGGSLQEEPGYKLQVQKSVTVQEGLCVLVPCSFSYPWNSWYSPPPLYVYWFRDGENQYFGEPVATNNPDRQVKSETQRRFRLLGDVSKKNCSLSIGDARMGDTGNYSFRVERGRNVKYTYLQNKLNLEVTALTEKPDVHFLEPLESGRLTRLSCSLPGSCEAGRPLTFSWTGDALSPLDPETTRSSELTLTPRPEDHGTNLTCHVKRQGAQVTTERTVQLNVSYAPQSLAISIFFRNGTGTALRILSNGMSVPIVEGQSLFLTCTVDSNPPASLSWFRDGKALNPSQTSVSGILELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQEGSWPLVLTLIRGALMGVGFLLTYGLTWIYYTRCGGPQGSRDERPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N4Y7</accession>
    <name>A0A2I3N4Y7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MAD2L1 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MAD2L1BP</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003897701.1">
        <property type="nucleotide sequence ID" value="XM_003897652.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N4Y7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000042926"/>
    <dbReference type="Ensembl" id="ENSPANT00000054718.2">
        <property type="protein sequence ID" value="ENSPANP00000042926.2"/>
        <property type="gene ID" value="ENSPANG00000020360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024190"/>
    <dbReference type="KEGG" id="panu:101024190"/>
    <dbReference type="CTD" id="9587"/>
    <dbReference type="GeneTree" id="ENSGT00390000003812"/>
    <dbReference type="OMA" id="KCQQVLM"/>
    <dbReference type="OrthoDB" id="6334764at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020360">
        <property type="expression patterns" value="Expressed in ascending colon and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N4Y7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902426">
        <property type="term" value="P:deactivation of mitotic spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.20:FF:000001">
        <property type="entry name" value="MAD2L1 binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042926.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="274" mass="31076" checksum="CF522B5A237DEE22" modified="2022-05-25" version="2">MAAPEAEVLSPASVPDLEWYEKSEETHASQIELLETSSTQEPLNPSEPFCPRDCMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKNFYRKPSPQAEEMLKKKPRATTEVSSRKCQQAVAELESVLSHLEDFFARTLVPRVLILLGGNSLSPKEFYELDLSLLAPYSVDQSLSTAACLRRLFRAIFMADAFSELQAPPLMGTIIMAQGHRDCGEDWFQPKLNYRVPSRGHKLTVTLSCGRPSIRTTAWEDYIWFQAPVTLKGFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N908</accession>
    <name>A0A2I3N908_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory factor X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RFX4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N908"/>
    <dbReference type="Ensembl" id="ENSPANT00000042335.2">
        <property type="protein sequence ID" value="ENSPANP00000044372.2"/>
        <property type="gene ID" value="ENSPANG00000006357.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006357">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 29 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N908">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF31">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX1-4/6/8-like BCD" evidence="2">
        <location>
            <begin position="107"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044372.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="639" mass="72398" checksum="5C4ADC5F1B17D358" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MUN1</accession>
    <name>A0A8I5MUN1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Capping protein regulator and myosin 1 linker 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CARMIL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CARMIL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202791.2">
        <property type="nucleotide sequence ID" value="XM_009204527.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000081768.1">
        <property type="protein sequence ID" value="ENSPANP00000047923.1"/>
        <property type="gene ID" value="ENSPANG00000008071.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006506"/>
    <dbReference type="CTD" id="55604"/>
    <dbReference type="GeneTree" id="ENSGT00940000155112"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000253">
        <property type="entry name" value="F-actin-uncapping protein LRRC16A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000009">
        <property type="entry name" value="F-actin-uncapping protein LRRC16A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF39">
        <property type="entry name" value="F-ACTIN-UNCAPPING PROTEIN LRRC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="11">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="10">
        <location>
            <begin position="790"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1177"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1235"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1248"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1317"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1344"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1375" mass="152065" checksum="30AD91A9A66610E6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MV03</accession>
    <name>A0A8I5MV03_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sesquipedalian</fullName>
            <shortName evidence="10">Ses</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PH domain-containing endocytic trafficking adaptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PHETA2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 10">Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms homodimers and heterodimers with PHETA1. Interacts with OCRL and INPP5B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the sesquipedalian family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905678.1">
        <property type="nucleotide sequence ID" value="XM_003905629.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021777319.1">
        <property type="nucleotide sequence ID" value="XM_021921627.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031512103.1">
        <property type="nucleotide sequence ID" value="XM_031656243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031512104.1">
        <property type="nucleotide sequence ID" value="XM_031656244.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031512105.1">
        <property type="nucleotide sequence ID" value="XM_031656245.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031512106.1">
        <property type="nucleotide sequence ID" value="XM_031656246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MV03"/>
    <dbReference type="Ensembl" id="ENSPANT00000070007.1">
        <property type="protein sequence ID" value="ENSPANP00000048159.1"/>
        <property type="gene ID" value="ENSPANG00000050664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101012749"/>
    <dbReference type="KEGG" id="panu:101012749"/>
    <dbReference type="CTD" id="150368"/>
    <dbReference type="GeneTree" id="ENSGT00940000162686"/>
    <dbReference type="OMA" id="PETICFS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000292">
        <property type="entry name" value="sesquipedalian-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF15">
        <property type="entry name" value="SESQUIPEDALIAN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 10" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="259" mass="28372" checksum="4DC59D86DEAE8937" modified="2022-05-25" version="1">MKLNERSVAHYALSDSPADHTGFLRTWGGPGTPSTPSGTGRRCWFVLKGNLLFSFESREGRAPLSLVVLEGCTVELAEAPVPEEFAFAICFDAPGVRPHLLAAEGPAAQEAWVKALSRASFGYMRLVVRELESQLQDARQSLALQRRSSWKSVAGRCKPQAPNHRSVGLENGHSLSKDSSPVGLVEEGGSRSSGRGLAEWELQGPASLLLGRGQSPVSPETSCFSTLHDWYGQEIMELRQCWQQRAQRSQPKCEEQDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0C3</accession>
    <name>A0A8I5N0C3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Potassium voltage-gated channel subfamily C member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KCNC2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003906842.1">
        <property type="nucleotide sequence ID" value="XM_003906793.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009179486.1">
        <property type="nucleotide sequence ID" value="XM_009181222.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0C3"/>
    <dbReference type="SMR" id="A0A8I5N0C3"/>
    <dbReference type="Ensembl" id="ENSPANT00000077830.1">
        <property type="protein sequence ID" value="ENSPANP00000048716.1"/>
        <property type="gene ID" value="ENSPANG00000025710.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006687"/>
    <dbReference type="KEGG" id="panu:101006687"/>
    <dbReference type="CTD" id="3747"/>
    <dbReference type="GeneTree" id="ENSGT00940000157371"/>
    <dbReference type="OMA" id="ELNTACN"/>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060081">
        <property type="term" value="P:membrane hyperpolarization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0099605">
        <property type="term" value="P:regulation of action potential firing rate"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="BTB_KCNC2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000011">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.120.350:FF:000014">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily C member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
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        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KCHANNEL"/>
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        <property type="entry name" value="KVCHANNEL"/>
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    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
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    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
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    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="310"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="382"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="424"/>
            <end position="441"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="21">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="38"/>
            <end position="93"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="538"/>
            <end position="572"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="56"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="638" mass="70226" checksum="211CAF8395A58C5D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N544</accession>
    <name>A0A8I5N544_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium-dependent phosphate transport protein 2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Na(+)-dependent phosphate cotransporter 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sodium/phosphate cotransporter 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 34 member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC34A2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in actively transporting phosphate into cells via Na(+) cotransport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71255"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71256"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898602.1">
        <property type="nucleotide sequence ID" value="XM_003898553.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N544"/>
    <dbReference type="Ensembl" id="ENSPANT00000066955.1">
        <property type="protein sequence ID" value="ENSPANP00000054269.1"/>
        <property type="gene ID" value="ENSPANG00000043751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101011533"/>
    <dbReference type="KEGG" id="panu:101011533"/>
    <dbReference type="CTD" id="10568"/>
    <dbReference type="GeneTree" id="ENSGT00950000183177"/>
    <dbReference type="OMA" id="GCPKCCR"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF23">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="690" mass="75630" checksum="110AB79ACA77B88D" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N5T6</accession>
    <name>A0A8I5N5T6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EEF1A lysine methyltransferase 2</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methyltransferase-like protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein-lysine N-methyltransferase METTL10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">EEF1AKMT2</name>
        <name evidence="7" type="synonym">METTL10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_021799514.1">
        <property type="nucleotide sequence ID" value="XM_021943822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N5T6"/>
    <dbReference type="Ensembl" id="ENSPANT00000062095.1">
        <property type="protein sequence ID" value="ENSPANP00000055596.1"/>
        <property type="gene ID" value="ENSPANG00000020335.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020247"/>
    <dbReference type="KEGG" id="panu:101020247"/>
    <dbReference type="CTD" id="399818"/>
    <dbReference type="GeneTree" id="ENSGT00390000013399"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000172">
        <property type="entry name" value="EEF1A lysine methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="236" mass="26070" checksum="32A55101CED58006" modified="2022-05-25" version="1">MSSDADGGSGAEVAALSDKDSPGEDGFVPSALGTREHWDAVYERELQTFREFGDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLSTQLSGFHICIDKGTFDAISLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNWTKEELLNEFSEGFELFEELPTPKFSFGGRSGNSVAALVFQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NA59</accession>
    <name>A0A8I5NA59_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor-type tyrosine-protein phosphatase C</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Leukocyte common antigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">T200</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">PTPRC</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_021784662.2">
        <property type="nucleotide sequence ID" value="XM_021928970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NA59"/>
    <dbReference type="Ensembl" id="ENSPANT00000075096.1">
        <property type="protein sequence ID" value="ENSPANP00000049987.1"/>
        <property type="gene ID" value="ENSPANG00000016201.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004607"/>
    <dbReference type="CTD" id="5788"/>
    <dbReference type="GeneTree" id="ENSGT00940000159457"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14558">
        <property type="entry name" value="R-PTP-C-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14557">
        <property type="entry name" value="R-PTPc-C-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001462">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000033">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000042">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024739">
        <property type="entry name" value="PTP_recept_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016335">
        <property type="entry name" value="Ptprc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF539">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12567">
        <property type="entry name" value="CD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12453">
        <property type="entry name" value="PTP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002004">
        <property type="entry name" value="Leukocyte_common_antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
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                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
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                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
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                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC25"/>
    <dbReference type="Ensembl" id="ENSPANT00000067554.1">
        <property type="protein sequence ID" value="ENSPANP00000055744.1"/>
        <property type="gene ID" value="ENSPANG00000039911.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="100" mass="11445" checksum="E6398A75212FEB8C" modified="2022-05-25" version="1">QWEPQLEDGRDVLVSLANSLLDYFFCERRSFTLVAQAEVQWCNPGSLQPPPPGFKQFSYLSLPSSWDYRHAPSRLANFVFLVETRFLHVGQAGLELLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5ND66</accession>
    <name>A0A8I5ND66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="14">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">XRN2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Possesses 5'-&gt;3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with POLR2A and SMN1/SMN2. Interacts with CDKN2AIP and NKRF. Interacts with CDKN2AIPNL; the interaction is direct. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner. Interacts with DHX34; the interaction is RNA-independent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5ND66"/>
    <dbReference type="Ensembl" id="ENSPANT00000074778.1">
        <property type="protein sequence ID" value="ENSPANP00000059725.1"/>
        <property type="gene ID" value="ENSPANG00000018088.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00670000098098"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="17">
        <location>
            <begin position="326"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="943" mass="107564" checksum="8151DC8AA743ABCE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NF89</accession>
    <name>A0A8I5NF89_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the humanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NF89"/>
    <dbReference type="Ensembl" id="ENSPANT00000060795.1">
        <property type="protein sequence ID" value="ENSPANP00000061237.1"/>
        <property type="gene ID" value="ENSPANG00000044818.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000282373"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900118">
        <property type="term" value="P:negative regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20245">
        <property type="entry name" value="humanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028139">
        <property type="entry name" value="Humanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33895:SF7">
        <property type="entry name" value="HUMANIN-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33895">
        <property type="entry name" value="HUMANIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15040">
        <property type="entry name" value="Humanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="23" mass="2611" checksum="8C7D48F4B504B14F" modified="2022-05-25" version="1">MATRGFNCLLLSTSEIDLSVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHN8</accession>
    <name>A0A8I5NHN8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907367.4">
        <property type="nucleotide sequence ID" value="XM_003907318.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHN8"/>
    <dbReference type="Ensembl" id="ENSPANT00000000821.3">
        <property type="protein sequence ID" value="ENSPANP00000060680.1"/>
        <property type="gene ID" value="ENSPANG00000003482.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004138"/>
    <dbReference type="KEGG" id="panu:101004138"/>
    <dbReference type="GeneTree" id="ENSGT01140000282516"/>
    <dbReference type="OMA" id="DTFRWHE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070553">
        <property type="term" value="F:nicotinic acid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15201">
        <property type="entry name" value="7tmA_HCAR1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000241">
        <property type="entry name" value="Hydroxycarboxylic acid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051893">
        <property type="entry name" value="HCARs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46048">
        <property type="entry name" value="HYDROXYCARBOXYLIC ACID RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46048:SF6">
        <property type="entry name" value="HYDROXYCARBOXYLIC ACID RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="363" mass="42093" checksum="AF44C428CEA29214" modified="2022-05-25" version="1">MNWHHPQDHFLVIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGVTIGLTVHLLKRKMLIQNGTANLCSSFSICDTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVAVRIRIFWLLRTFGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLRRKMTGEPDNNRSTSVELTGDPNTTRGAPEALMANPDEPWSPSYLGPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NIT1</accession>
    <name>A0A8I5NIT1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adhesion G protein-coupled receptor D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADGRD1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIT1"/>
    <dbReference type="Ensembl" id="ENSPANT00000075853.1">
        <property type="protein sequence ID" value="ENSPANP00000049355.1"/>
        <property type="gene ID" value="ENSPANG00000005289.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159783"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014819">
        <property type="term" value="P:regulation of skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000368">
        <property type="entry name" value="Adhesion G protein-coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000008">
        <property type="entry name" value="Adhesion G-protein coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF216">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035170444" evidence="9">
        <location>
            <begin position="29"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="12">
        <location>
            <begin position="111"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="403"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="598"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="997" mass="109622" checksum="6FACE3CA330EFA2B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJ96</accession>
    <name>A0A8I5NJ96_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF74</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905294.2">
        <property type="nucleotide sequence ID" value="XM_003905245.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJ96"/>
    <dbReference type="Ensembl" id="ENSPANT00000075535.1">
        <property type="protein sequence ID" value="ENSPANP00000057803.1"/>
        <property type="gene ID" value="ENSPANG00000022560.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101000754"/>
    <dbReference type="KEGG" id="panu:101000754"/>
    <dbReference type="CTD" id="7625"/>
    <dbReference type="GeneTree" id="ENSGT00940000162000"/>
    <dbReference type="OMA" id="RPEWQLK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000822">
        <property type="entry name" value="Zinc finger protein 234, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000622">
        <property type="entry name" value="zinc finger protein 26 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002207">
        <property type="entry name" value="Zinc finger protein 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000416">
        <property type="entry name" value="zinc finger protein 879 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000229">
        <property type="entry name" value="Zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000330">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF400">
        <property type="entry name" value="ZINC FINGER PROTEIN 487-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="644" mass="72213" checksum="E81D4D85CF0F7D66" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NS17</accession>
    <name>A0A8I5NS17_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031517727.1">
        <property type="nucleotide sequence ID" value="XM_031661867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NS17"/>
    <dbReference type="Ensembl" id="ENSPANT00000080403.1">
        <property type="protein sequence ID" value="ENSPANP00000052457.1"/>
        <property type="gene ID" value="ENSPANG00000038165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116272942"/>
    <dbReference type="KEGG" id="panu:116272942"/>
    <dbReference type="GeneTree" id="ENSGT00940000174248"/>
    <dbReference type="OMA" id="LMTWVFP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
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    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="52" mass="6010" checksum="366762757BEDEE44" modified="2022-05-25" version="1">MYVVGYIKPSKFQKIIYVNMISVILSFILMFGNLMCLSSYYSSSLLMTWVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NST9</accession>
    <name>A0A8I5NST9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serpin B6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms a complex with the monomeric form of beta-tryptase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202618.1">
        <property type="nucleotide sequence ID" value="XM_009204354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NST9"/>
    <dbReference type="SMR" id="A0A8I5NST9"/>
    <dbReference type="Ensembl" id="ENSPANT00000068237.1">
        <property type="protein sequence ID" value="ENSPANP00000060395.1"/>
        <property type="gene ID" value="ENSPANG00000015755.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009169"/>
    <dbReference type="CTD" id="5269"/>
    <dbReference type="GeneTree" id="ENSGT00940000154931"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19565">
        <property type="entry name" value="serpinB6_CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000001">
        <property type="entry name" value="Serpin family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000018">
        <property type="entry name" value="Serpin family B member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF204">
        <property type="entry name" value="SERPIN B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="9">
        <location>
            <begin position="27"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="390" mass="43863" checksum="719D2F2F338E1626" modified="2022-05-25" version="1">MGAAQSLPGHRSAIMDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQVLSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRTANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINSWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFKGNWNEQFDKENTEERRFKVSKNEEKPVQMMFMQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEKVEVSLPRFKLEESYDMESVLCSLGMTDAFELGKADFSGMSKADLCLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NV20</accession>
    <name>A0A8I5NV20_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAF family member associated NFKB activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TANK</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017802065.2">
        <property type="nucleotide sequence ID" value="XM_017946576.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779352.1">
        <property type="nucleotide sequence ID" value="XM_021923660.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779353.1">
        <property type="nucleotide sequence ID" value="XM_021923661.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507166.1">
        <property type="nucleotide sequence ID" value="XM_031651306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NV20"/>
    <dbReference type="Ensembl" id="ENSPANT00000074258.1">
        <property type="protein sequence ID" value="ENSPANP00000059884.1"/>
        <property type="gene ID" value="ENSPANG00000000040.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020486"/>
    <dbReference type="KEGG" id="panu:101020486"/>
    <dbReference type="CTD" id="10010"/>
    <dbReference type="GeneTree" id="ENSGT00390000008712"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035800">
        <property type="term" value="F:deubiquitinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140678">
        <property type="term" value="F:molecular function inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010804">
        <property type="term" value="P:negative regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903003">
        <property type="term" value="P:positive regulation of protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041641">
        <property type="entry name" value="CALCOCO1/2_Zn_UBZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039669">
        <property type="entry name" value="TANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024581">
        <property type="entry name" value="TBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15249">
        <property type="entry name" value="TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15249:SF0">
        <property type="entry name" value="TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12845">
        <property type="entry name" value="TBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51905">
        <property type="entry name" value="ZF_UBZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ1-type" evidence="8">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="425" mass="47758" checksum="7ED57A311DCA76D7" modified="2022-05-25" version="1">MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDGNYGCVPLLEDSETRKNNLTVDQPHNKVISGIAKEKLPKVRRQEVSSPRKETSARSLGSPLLHERGSIEKTFWDLKEEFHRICMLAKAQKDHLSKLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITCVTPRGLCRDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPGILSPATSEAMCQEKFNTEFRDNPGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNTFPLLDPSDAPFPSLDSPGKAIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSHFNGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYB3</accession>
    <name>A0A8I5NYB3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NYB3"/>
    <dbReference type="Ensembl" id="ENSPANT00000067113.1">
        <property type="protein sequence ID" value="ENSPANP00000059746.1"/>
        <property type="gene ID" value="ENSPANG00000047544.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="CELIQPX"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="847" mass="99153" checksum="B3AEDA35ED158C19" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NZF2</accession>
    <name>A0A8I5NZF2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein 736</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NZF2"/>
    <dbReference type="SMR" id="A0A8I5NZF2"/>
    <dbReference type="Ensembl" id="ENSPANT00000082434.1">
        <property type="protein sequence ID" value="ENSPANP00000056634.1"/>
        <property type="gene ID" value="ENSPANG00000040170.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154251"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000524">
        <property type="entry name" value="Zinc finger protein 155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000034">
        <property type="entry name" value="zinc finger protein 25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000023">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000307">
        <property type="entry name" value="Zinc finger protein ZFP69 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF107">
        <property type="entry name" value="ZFP2 ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="49995" checksum="C2084EF5B9F1386E" modified="2022-05-25" version="1">MGVLTFRDVAIEFSPEEWECLDSAQQCLYRDVMLENYRNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVVKHPAGSFHFTAEILPEHDIKDSFQKVILRKYGSCDLNNLHLKKDNQSVGNCKGQKSSYNGLHQCFSTTHSKTCHCNKFGSDCQLCSIFTENKEIFSREKCYKCEECGKDCRLFSDFTRHKKVHTAERCYKCEECGKPFKKFSNLTEHKRVHTGEKPYKCEGCGKTFTCSSTLVKHKRNHTGDRPYKCEECGKAFKCFSDLTNHKRIHTGEKPYKCEECNKAYRWFSDLAKHKIIHTGEKPYKCNECGKAFKWFSALSKHKRIHTGEKPYICEECGKAFTRSSTLFNHKRIHMEERPYKCEECGKTFKCFSDLTNHKRIHTGEKPYKCEECGKASSWFSHLIRHKRIHTREKLHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P170</accession>
    <name>A0A8I5P170_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium homeostasis modulator family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CALHM2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009213556.1">
        <property type="nucleotide sequence ID" value="XM_009215292.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799778.1">
        <property type="nucleotide sequence ID" value="XM_017944289.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799779.1">
        <property type="nucleotide sequence ID" value="XM_017944290.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799780.1">
        <property type="nucleotide sequence ID" value="XM_017944291.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799781.1">
        <property type="nucleotide sequence ID" value="XM_017944292.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017799782.1">
        <property type="nucleotide sequence ID" value="XM_017944293.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021799340.1">
        <property type="nucleotide sequence ID" value="XM_021943648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P170"/>
    <dbReference type="Ensembl" id="ENSPANT00000077013.1">
        <property type="protein sequence ID" value="ENSPANP00000058099.1"/>
        <property type="gene ID" value="ENSPANG00000048513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101004824"/>
    <dbReference type="KEGG" id="panu:101004824"/>
    <dbReference type="CTD" id="51063"/>
    <dbReference type="GeneTree" id="ENSGT01030000234610"/>
    <dbReference type="OMA" id="LNTHTWN"/>
    <dbReference type="OrthoDB" id="9865653at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903978">
        <property type="term" value="P:regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF3">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="323" mass="36135" checksum="20BE0C47E9762639" modified="2022-05-25" version="1">MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELVANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2L4</accession>
    <name>A0A8I5P2L4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphofructokinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031517566.1">
        <property type="nucleotide sequence ID" value="XM_031661706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P2L4"/>
    <dbReference type="Ensembl" id="ENSPANT00000076946.1">
        <property type="protein sequence ID" value="ENSPANP00000059311.1"/>
        <property type="gene ID" value="ENSPANG00000046677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116272862"/>
    <dbReference type="KEGG" id="panu:116272862"/>
    <dbReference type="GeneTree" id="ENSGT00940000155002"/>
    <dbReference type="OMA" id="HGEKQCG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF5">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="137" mass="15180" checksum="7BD74BBA1E3BA585" modified="2022-05-25" version="1">MGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITVKLKEARGRGKGTGEGGRLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZQ6</accession>
    <name>A0A8I5QZQ6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZQ6"/>
    <dbReference type="Ensembl" id="ENSPANT00000073014.1">
        <property type="protein sequence ID" value="ENSPANP00000049894.1"/>
        <property type="gene ID" value="ENSPANG00000047700.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="EMESYCV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="12194" checksum="0412248FAC2ADA60" modified="2022-05-25" version="1">MLQNRKSSRLKSKCQGHTAGGEMESYCVALAGVQWHDLGSLQPLPPGFKQFSCLSFLSSWDYRYLPIHLTNFCIFSRDRVSPCWPGWSQTPDLRRSARLDLPKCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZX3</accession>
    <name>A0A8I5QZX3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-X-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZX3"/>
    <dbReference type="Ensembl" id="ENSPANT00000074453.1">
        <property type="protein sequence ID" value="ENSPANP00000050446.1"/>
        <property type="gene ID" value="ENSPANG00000043093.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163986"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.50.40:FF:000004">
        <property type="entry name" value="C-X-C motif chemokine"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
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    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018048">
        <property type="entry name" value="Chemokine_CXC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
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    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF192">
        <property type="entry name" value="GROWTH-REGULATED ALPHA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00471">
        <property type="entry name" value="SMALL_CYTOKINES_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4 11" id="KW-0202">Cytokine</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="13">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="263" mass="27902" checksum="27875D196F1DF111" modified="2022-05-25" version="1">MSSREVTPPGKDVARSLRGSKGSDPRSTVLGSRSAPRRRNLGISESGGLSLPLQGFGAESEHSTVGGSYARQPDLAFTRECPHPTPPQRRGCAFLPDSGSIWISGNFPGPGLRAFQPQPCIKGVHHAHRATEPRPQAAPCQLSLSSHSRPKRLLSPMASPALSTTPSNLRLLRVALLLLLLVAASRRAAGASLVTELRCQCLQTLHGIHPKNIQSVNVKAPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIGKMLNNGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R022</accession>
    <name>A0A8I5R022_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">SERTA domain containing 1</fullName>
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    <gene>
        <name evidence="3" type="primary">SERTAD1</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Quiroz J.Q."/>
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                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016528">
        <property type="term" value="C:sarcoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052262">
        <property type="entry name" value="E2F-SERTA_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277">
        <property type="entry name" value="CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277:SF12">
        <property type="entry name" value="SERTA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="236" mass="24674" checksum="B1BFA6B060F06BAA" modified="2022-05-25" version="1">MLSKGLKRKREEEEEKEPLAVDAWWLDPGHASVAQAPPAVASSSLFDLSVLKLHHSLQQSEPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADNLLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGPATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYLMDVLVGTQALERPPGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R216</accession>
    <name>A0A8I5R216_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R216"/>
    <dbReference type="Ensembl" id="ENSPANT00000070090.1">
        <property type="protein sequence ID" value="ENSPANP00000057805.1"/>
        <property type="gene ID" value="ENSPANG00000042015.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183016"/>
    <dbReference type="OMA" id="QIDCNTI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="105" mass="12414" checksum="FE28B6D639F86CF2" modified="2022-05-25" version="1">MYLDLKKQIDCNTILVEEFNTPFSAMDRSFRQKINKETSDMNCTREQMDLTNIYRTFHPTGTEYTLFSTAHQSFSRINRMLSHKISLLNLRISKSYQVSFLTTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6T5</accession>
    <name>A0A8I5R6T5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-pass membrane protein with coiled-coil domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMCO1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003895380.2">
        <property type="nucleotide sequence ID" value="XM_003895331.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6T5"/>
    <dbReference type="Ensembl" id="ENSPANT00000071483.1">
        <property type="protein sequence ID" value="ENSPANP00000052495.1"/>
        <property type="gene ID" value="ENSPANG00000049201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101024039"/>
    <dbReference type="KEGG" id="panu:101024039"/>
    <dbReference type="CTD" id="255798"/>
    <dbReference type="GeneTree" id="ENSGT00390000010564"/>
    <dbReference type="OMA" id="FMITNMV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027875">
        <property type="entry name" value="DUF4547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35979">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35979:SF1">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15080">
        <property type="entry name" value="DUF4547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="214" mass="24711" checksum="D08AB265D696EE24" modified="2022-05-25" version="1">MNNETTTLISLKEAMKRVDHKLQVLEAQFRELDFTKDNLMQKFERHSKTLANQAAQDEMWTAVRALEFTSMELNILYSYVIEVLICLHTRVLEKLPDLVRGLPTLASVLRRKVKNERIRVVWDSILEECGLQEGDITALCTFFIAHGNKAEHYTDKARQTYIRDITFLITNMVKNQALQDSLLRAVQVIEKGKAVRTPEEQKSPLKESIPPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R7D1</accession>
    <name>A0A8I5R7D1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R7D1"/>
    <dbReference type="Ensembl" id="ENSPANT00000063256.1">
        <property type="protein sequence ID" value="ENSPANP00000053636.1"/>
        <property type="gene ID" value="ENSPANG00000050307.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162491"/>
    <dbReference type="OMA" id="MQKEYNA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033300">
        <property type="term" value="F:dehydroascorbic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17431">
        <property type="entry name" value="MFS_GLUT_Class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000040">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF99">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="465" mass="50779" checksum="4144DA5A403EEEBF" modified="2022-05-25" version="1">MGTQKIIKEFINKSLTEKANIPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSATLPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSTLMTISLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIQPPKETTTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R8A8</accession>
    <name>A0A8I5R8A8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R8A8"/>
    <dbReference type="Ensembl" id="ENSPANT00000071332.1">
        <property type="protein sequence ID" value="ENSPANP00000055760.1"/>
        <property type="gene ID" value="ENSPANG00000042962.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286957"/>
    <dbReference type="OMA" id="QTILCHY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="162" mass="18171" checksum="28ECBF1FACA09777" modified="2022-05-25" version="1">MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKNFSCLHHGLKVWNLPWRIFTLSPESFLPPLCKRDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A4K2N6</accession>
    <name>A4K2N6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TP53 target 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">TP53-target gene 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C20orf10</name>
        <name evidence="3" type="synonym">TP53TG5</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Genome Res." volume="17" first="276" last="286">
            <title>Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage.</title>
            <authorList>
                <consortium name="NISC comparative sequencing program"/>
                <person name="Hurle B."/>
                <person name="Swanson W."/>
                <person name="Green E.D."/>
            </authorList>
            <dbReference type="PubMed" id="17267810"/>
            <dbReference type="DOI" id="10.1101/gr.6004607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="DP000036">
        <property type="protein sequence ID" value="ABO52919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162206.1">
        <property type="nucleotide sequence ID" value="NM_001168735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4K2N6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017657"/>
    <dbReference type="Ensembl" id="ENSPANT00000022654.3">
        <property type="protein sequence ID" value="ENSPANP00000017657.1"/>
        <property type="gene ID" value="ENSPANG00000011734.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137167"/>
    <dbReference type="KEGG" id="panu:100137167"/>
    <dbReference type="CTD" id="27296"/>
    <dbReference type="eggNOG" id="ENOG502SYWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017387"/>
    <dbReference type="HOGENOM" id="CLU_083634_0_0_1"/>
    <dbReference type="OMA" id="GWRSRSQ"/>
    <dbReference type="OrthoDB" id="9120343at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011734">
        <property type="expression patterns" value="Expressed in testis and 23 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029290">
        <property type="entry name" value="TP53TG5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15562">
        <property type="entry name" value="TP53-TARGET GENE 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15562:SF0">
        <property type="entry name" value="TP53-TARGET GENE 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15331">
        <property type="entry name" value="TP53IP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABO52919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="290" mass="33729" checksum="0F5ECA5FC582CB6F" modified="2007-05-01" version="1">MSPSAKKRPKNSRVSKMQDEKPQDKTEQPLSKVIERNRLRTVLKNLSLLKLLKSSNRRIQELHKLAKRCWHSLLSVPKILRISSGENSACNKAKQNNEEFQEIGCSKKELKSKKLESTGDPKKKEYKEWKPQVQSRMSNKAKTSSAAMPWKEKHVEPEVPRTSRDHGLNLGAQGRQLLTEGPQVIFIKPYHNRTPMGHMKQLNVADQWIWFEGLPTRIHLPAPRVMCRSSTLRWVKRRCTRFCSASLEMPMWHPYKVDVTWTGARGASRGWRSRSQLKGRDGWRNSRVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A9RA80</accession>
    <name>A9RA80_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fascin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">FSCN3</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-12" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as an actin bundling protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fascin family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000510">
        <property type="protein sequence ID" value="ABX89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162399.1">
        <property type="nucleotide sequence ID" value="NM_001168928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202080.1">
        <property type="nucleotide sequence ID" value="XM_009203816.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9RA80"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006153"/>
    <dbReference type="Ensembl" id="ENSPANT00000008764.3">
        <property type="protein sequence ID" value="ENSPANP00000006153.1"/>
        <property type="gene ID" value="ENSPANG00000022296.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137393"/>
    <dbReference type="KEGG" id="panu:100137393"/>
    <dbReference type="CTD" id="29999"/>
    <dbReference type="eggNOG" id="ENOG502QSD9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183157"/>
    <dbReference type="HOGENOM" id="CLU_030960_2_0_1"/>
    <dbReference type="OMA" id="MADGHPM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022296">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031253">
        <property type="term" value="C:cell projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23346">
        <property type="entry name" value="beta-trefoil_FSCN3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23350">
        <property type="entry name" value="beta-trefoil_FSCN3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23354">
        <property type="entry name" value="beta-trefoil_FSCN3_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23358">
        <property type="entry name" value="beta-trefoil_FSCN3_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000045">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000050">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000051">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000055">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
        <property type="entry name" value="FASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF1">
        <property type="entry name" value="FASCIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005682">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="272"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABX89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="498" mass="56736" checksum="2A031E132A91F68D" modified="2008-02-05" version="1">MDEMEWIHRHPKAEDLRVGLISWAGTYLTFEACKNTVTATAKSLGRRQTWEILVSNEHETQAVVRLKSVQGLYLLCECDGTMCYGRPRTSHHGCFLLRFHRNSKWTLQCLISGRYLESNGKDVFCTSRVLSAYHMWTPRPALHVHVILYSPIHRCYARADPTMGRIWVDAAVPCLEECGFLLHFRDGCYHLETSTHHFLSHVDRLFSQPSSQTAFHMQVRPGGLVALCDGEGGMLYPQGTHLLLGLGCNPVRGEEWFILQHCPTWVRLRSKTRRFISVIYDDEVRAASERLTPMSLFQFECDSESPTVQLRSANGYYLAQRRHRAVMADGHPLESDTFFRMHWNCGRIILQSCRGRFLGIAPNGLLMANATLPGPNEEFGILFANRPFLVLRGRYGYVGSSSGHDLIQCNQDQPDRIHLLPCRQGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELQGSNLLTVLAPNGFYMRADQSGTLLADSEDITKECIWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0CM67</accession>
    <accession>A0A096NBP0</accession>
    <name>B0CM67_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">MEN1</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2008-01" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DP000551">
        <property type="protein sequence ID" value="ABY63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162471.1">
        <property type="nucleotide sequence ID" value="NM_001169000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0CM67"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010194"/>
    <dbReference type="Ensembl" id="ENSPANT00000001840.3">
        <property type="protein sequence ID" value="ENSPANP00000010194.2"/>
        <property type="gene ID" value="ENSPANG00000004747.3"/>
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    <dbReference type="GeneID" id="100137471"/>
    <dbReference type="KEGG" id="panu:100137471"/>
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    <dbReference type="eggNOG" id="ENOG502QUYK">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000014237"/>
    <dbReference type="HOGENOM" id="CLU_018646_0_0_1"/>
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    <dbReference type="OrthoDB" id="5962932at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
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    <dbReference type="Bgee" id="ENSPANG00000004747">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:four-way junction DNA binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of JNK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002076">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030511">
        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010332">
        <property type="term" value="P:response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045064">
        <property type="term" value="P:T-helper 2 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14456">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007747">
        <property type="entry name" value="Menin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693:SF3">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05053">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021162"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABY63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="615" mass="68033" checksum="5E102352C0BAB9B0" modified="2008-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ML73</accession>
    <name>A0A096ML73_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cx9C motif-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mature T-cell proliferation 1 neighbor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mature T-cell proliferation-1 type A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein p8 MTCP-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CMC4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918543.1">
        <property type="nucleotide sequence ID" value="XM_003918494.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003918544.1">
        <property type="nucleotide sequence ID" value="XM_003918495.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009196830.1">
        <property type="nucleotide sequence ID" value="XM_009198566.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009196831.1">
        <property type="nucleotide sequence ID" value="XM_009198567.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096ML73"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000279"/>
    <dbReference type="Ensembl" id="ENSPANT00000004463.3">
        <property type="protein sequence ID" value="ENSPANP00000000279.1"/>
        <property type="gene ID" value="ENSPANG00000017783.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004919"/>
    <dbReference type="KEGG" id="panu:101004919"/>
    <dbReference type="CTD" id="100272147"/>
    <dbReference type="eggNOG" id="ENOG502SC73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012647"/>
    <dbReference type="HOGENOM" id="CLU_177210_1_1_1"/>
    <dbReference type="OMA" id="QANKYME"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017783">
        <property type="expression patterns" value="Expressed in heart and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000002">
        <property type="entry name" value="cx9C motif-containing protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="68" mass="7731" checksum="3D3F425C35BA2E53" modified="2014-11-26" version="1">MPQKDPCQKQACEIQKCLQANNYMESKCQAVIQELRKCCAQYPKGRSVVCSGFEKEEEENLTLKSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMX5</accession>
    <name>A0A096MMX5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">B3GALT2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_003893417.1">
        <property type="nucleotide sequence ID" value="XM_003893368.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MMX5"/>
    <dbReference type="SMR" id="A0A096MMX5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000960"/>
    <dbReference type="Ensembl" id="ENSPANT00000027522.3">
        <property type="protein sequence ID" value="ENSPANP00000000960.1"/>
        <property type="gene ID" value="ENSPANG00000017876.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016126"/>
    <dbReference type="KEGG" id="panu:101016126"/>
    <dbReference type="CTD" id="8707"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155117"/>
    <dbReference type="HOGENOM" id="CLU_036849_2_1_1"/>
    <dbReference type="OMA" id="TSYHFKY"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017876">
        <property type="expression patterns" value="Expressed in Ammon's horn and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045821">
        <property type="entry name" value="B3GT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF19">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19341">
        <property type="entry name" value="B3GALT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-1,3-galactosyltransferase 2 N-terminal" evidence="15">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="422" mass="49213" checksum="BA62942D6AFB4B0C" modified="2014-11-26" version="1">MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPVTYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLAPGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVATYCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPN2</accession>
    <name>A0A096MPN2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroplakin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UPK2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031508751.1">
        <property type="nucleotide sequence ID" value="XM_031652891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MPN2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001693"/>
    <dbReference type="Ensembl" id="ENSPANT00000008455.3">
        <property type="protein sequence ID" value="ENSPANP00000001693.1"/>
        <property type="gene ID" value="ENSPANG00000018904.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025931"/>
    <dbReference type="KEGG" id="panu:101025931"/>
    <dbReference type="CTD" id="7379"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006115"/>
    <dbReference type="HOGENOM" id="CLU_126065_0_0_1"/>
    <dbReference type="OMA" id="SFMVPPC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018904">
        <property type="expression patterns" value="Expressed in urinary bladder and 36 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09967">
        <property type="entry name" value="UP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009952">
        <property type="entry name" value="Uroplakin-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17573">
        <property type="entry name" value="UROPLAKIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17573:SF0">
        <property type="entry name" value="UROPLAKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07353">
        <property type="entry name" value="Uroplakin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001920760" evidence="2">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="184" mass="19358" checksum="1B617034CB6630DB" modified="2014-11-26" version="1">MAPLLPIQTLPLILILLAVLSPGIADFNISSLSGLLSPALTESLLVALPPCHLTGGNATLTVRRANDSKVVKSSFVVPPCRGRRELVSVVDSGAGFTVTRLSAYQVTNLVPGTKYYISYLVKKGTATESSREIPMSTLPRSNMESIGLGMAHTGGMVVITVLLSVTMFLLVLGFIIALALGAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQE1</accession>
    <name>A0A096MQE1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909771.1">
        <property type="nucleotide sequence ID" value="XM_003909722.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQE1"/>
    <dbReference type="SMR" id="A0A096MQE1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001968"/>
    <dbReference type="Ensembl" id="ENSPANT00000023259.3">
        <property type="protein sequence ID" value="ENSPANP00000001968.1"/>
        <property type="gene ID" value="ENSPANG00000005281.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024632"/>
    <dbReference type="KEGG" id="panu:101024632"/>
    <dbReference type="CTD" id="746"/>
    <dbReference type="eggNOG" id="KOG4452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010089"/>
    <dbReference type="HOGENOM" id="CLU_180449_0_0_1"/>
    <dbReference type="OMA" id="MERYVGP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005281">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160226">
        <property type="term" value="C:oligosaccharyltransferase complex A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160227">
        <property type="term" value="C:oligosaccharyltransferase complex B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062062">
        <property type="term" value="F:oligosaccharyltransferase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="79" mass="9079" checksum="8105E40132994646" modified="2014-11-26" version="1">MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MR34</accession>
    <name>A0A096MR34_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase family member I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARSI</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900411.1">
        <property type="nucleotide sequence ID" value="XM_003900362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MR34"/>
    <dbReference type="SMR" id="A0A096MR34"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002228"/>
    <dbReference type="Ensembl" id="ENSPANT00000004188.3">
        <property type="protein sequence ID" value="ENSPANP00000002228.1"/>
        <property type="gene ID" value="ENSPANG00000013185.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012010"/>
    <dbReference type="KEGG" id="panu:101012010"/>
    <dbReference type="CTD" id="340075"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157656"/>
    <dbReference type="HOGENOM" id="CLU_006332_10_1_1"/>
    <dbReference type="OMA" id="WDWMKPS"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013185">
        <property type="expression patterns" value="Expressed in optic disc and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000002">
        <property type="entry name" value="Arylsulfatase family member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF68">
        <property type="entry name" value="ARYLSULFATASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001928102" evidence="7">
        <location>
            <begin position="24"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="569" mass="64243" checksum="D7EB6AB0BA9F79B5" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRG8</accession>
    <name>A0A096MRG8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding region-containing protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA-binding motif protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RNPC3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009212188.1">
        <property type="nucleotide sequence ID" value="XM_009213924.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507210.1">
        <property type="nucleotide sequence ID" value="XM_031651350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRG8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002369"/>
    <dbReference type="Ensembl" id="ENSPANT00000002817.3">
        <property type="protein sequence ID" value="ENSPANP00000002369.2"/>
        <property type="gene ID" value="ENSPANG00000012137.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101018016"/>
    <dbReference type="KEGG" id="panu:101018016"/>
    <dbReference type="CTD" id="55599"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063786"/>
    <dbReference type="HOGENOM" id="CLU_039888_2_1_1"/>
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        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="27"/>
            <end position="102"/>
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    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="420"/>
            <end position="503"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
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            <begin position="106"/>
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            <begin position="213"/>
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            <begin position="115"/>
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            <begin position="217"/>
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            <begin position="231"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025101"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025983"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00030578"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50102"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002369.2"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="518" mass="58627" checksum="701938A0B72CBE99" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MT97</accession>
    <name>A0A096MT97_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bridging integrator 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BIN3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in cytokinesis and septation where it has a role in the localization of F-actin.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSPANG00000020851.4"/>
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    <dbReference type="KEGG" id="panu:100998750"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:intracellular protein localization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:myoblast migration involved in skeletal muscle regeneration"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="BAR"/>
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            <begin position="9"/>
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            <begin position="220"/>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003025.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="253" mass="29615" checksum="ED5D140C00060D98" modified="2018-02-28" version="2">MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEEQTRKLQKDMKKSTDADLAMSKSAVKISLDLLSNPLCEQDQDLLSMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPSLNMAVKRREQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQAREELRPVREDFEAKNRQLLEEMPRFYGSRLDYFQPSFESLIRAQVVYYSEMHKIFGDLTQQLDQPGHSDEQRERENEAKLSELRALSIVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUQ5</accession>
    <name>A0A096MUQ5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NFYC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891716.1">
        <property type="nucleotide sequence ID" value="XM_003891667.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204175.1">
        <property type="nucleotide sequence ID" value="XM_009205911.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204181.1">
        <property type="nucleotide sequence ID" value="XM_009205917.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204187.1">
        <property type="nucleotide sequence ID" value="XM_009205923.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204188.1">
        <property type="nucleotide sequence ID" value="XM_009205924.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MUQ5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003571"/>
    <dbReference type="Ensembl" id="ENSPANT00000014442.3">
        <property type="protein sequence ID" value="ENSPANP00000003571.2"/>
        <property type="gene ID" value="ENSPANG00000026473.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010278"/>
    <dbReference type="KEGG" id="panu:101010278"/>
    <dbReference type="CTD" id="4802"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155689"/>
    <dbReference type="HOGENOM" id="CLU_045277_2_1_1"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026473">
        <property type="expression patterns" value="Expressed in cerebellum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MUQ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="288"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003571.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="439" mass="48134" checksum="86689F883213CAC4" modified="2018-02-28" version="2">MSTEGGFGGSSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSSTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKATGNSTPCTSSLPTTHPPSHRAGASCVCCSQPQQSSTSPPPSDALQWVVVEVSGTPNQLETHRELHAPLPGVTSLSPLHPSQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWJ5</accession>
    <name>A0A096MWJ5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC12A9</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. May play a role in lysosomal ion flux and osmoregulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with SLC12A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895856.2">
        <property type="nucleotide sequence ID" value="XM_003895807.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009200986.2">
        <property type="nucleotide sequence ID" value="XM_009202722.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031521399.1">
        <property type="nucleotide sequence ID" value="XM_031665539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWJ5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004251"/>
    <dbReference type="Ensembl" id="ENSPANT00000021081.3">
        <property type="protein sequence ID" value="ENSPANP00000004251.2"/>
        <property type="gene ID" value="ENSPANG00000007493.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015434"/>
    <dbReference type="KEGG" id="panu:101015434"/>
    <dbReference type="CTD" id="56996"/>
    <dbReference type="eggNOG" id="KOG1288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159400"/>
    <dbReference type="HOGENOM" id="CLU_001883_3_0_1"/>
    <dbReference type="OMA" id="NIKYWRP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007493">
        <property type="expression patterns" value="Expressed in aorta and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWJ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF98">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="16">
        <location>
            <begin position="42"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="17">
        <location>
            <begin position="547"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004251.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="914" mass="96200" checksum="DEBA9D4ACCA81A9F" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXE5</accession>
    <name>A0A096MXE5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidative stress-induced growth inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OSGIN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Monooxygenase catalytic activity. Involved in regulation of cytokinesis; promotes RHOA activity, probably acting locally at the midbody in late cytokinesis. Monooxygenase activity is involved in stabilizing transient structures between daughter cells, termed intercellular bridges, before abscission. Regulates differentiation and proliferation through the regulation of cell death.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the OKL38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917290.1">
        <property type="nucleotide sequence ID" value="XM_003917241.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003917291.3">
        <property type="nucleotide sequence ID" value="XM_003917242.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195212.1">
        <property type="nucleotide sequence ID" value="XM_009196948.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MXE5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004558"/>
    <dbReference type="Ensembl" id="ENSPANT00000006302.4">
        <property type="protein sequence ID" value="ENSPANP00000004558.3"/>
        <property type="gene ID" value="ENSPANG00000017404.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101008388"/>
    <dbReference type="KEGG" id="panu:101008388"/>
    <dbReference type="CTD" id="29948"/>
    <dbReference type="eggNOG" id="ENOG502QRUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006658"/>
    <dbReference type="OMA" id="ASWDIQT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017404">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000152">
        <property type="entry name" value="Oxidative stress-induced growth inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF15">
        <property type="entry name" value="OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004558.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="477" mass="51932" checksum="D9D63057E71CF629" modified="2022-05-25" version="3">MSSSGKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYVKPDAVHPHPLLQRKLTEAPGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGHMKSVLTWKHQEEHAIPHVVLGRNLPGGAWHSIEGSMVTLSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPNPNSCGAQDSSPLFQVSGFLSRDQGRQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGALTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRSLPGHRLLCFKEDCQAVFQDLKGVEKVFEVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSTKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYB1</accession>
    <name>A0A096MYB1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcitonin related polypeptide alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CALCA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcitonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009184784.1">
        <property type="nucleotide sequence ID" value="XM_009186520.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYB1"/>
    <dbReference type="Ensembl" id="ENSPANT00000076425.1">
        <property type="protein sequence ID" value="ENSPANP00000060666.1"/>
        <property type="gene ID" value="ENSPANG00000038842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101018863"/>
    <dbReference type="CTD" id="796"/>
    <dbReference type="GeneTree" id="ENSGT00940000162876"/>
    <dbReference type="OMA" id="MYVSQAA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007551">
        <property type="expression patterns" value="Expressed in thyroid gland and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031716">
        <property type="term" value="F:calcitonin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097646">
        <property type="term" value="P:calcitonin family receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021117">
        <property type="entry name" value="Calcitonin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021116">
        <property type="entry name" value="Calcitonin/adrenomedullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018360">
        <property type="entry name" value="Calcitonin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015476">
        <property type="entry name" value="Calcitonin_gene-rel_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001693">
        <property type="entry name" value="Calcitonin_peptide-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505:SF3">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505">
        <property type="entry name" value="CALCITONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00214">
        <property type="entry name" value="Calc_CGRP_IAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00817">
        <property type="entry name" value="CALCITONINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00113">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00258">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcitonin peptide-like" evidence="5">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="131" mass="14173" checksum="E6178AE89DD20E47" modified="2014-11-26" version="1">MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPDPATLSEEEARLLLAALVQDYVQMKASELGQEPETEGSRITAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQDWAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYC2</accession>
    <name>A0A096MYC2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBCC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TBCCD1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894749.2">
        <property type="nucleotide sequence ID" value="XM_003894700.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009199481.2">
        <property type="nucleotide sequence ID" value="XM_009201217.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYC2"/>
    <dbReference type="Ensembl" id="ENSPANT00000008714.3">
        <property type="protein sequence ID" value="ENSPANP00000004928.3"/>
        <property type="gene ID" value="ENSPANG00000003499.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019368"/>
    <dbReference type="KEGG" id="panu:101019368"/>
    <dbReference type="CTD" id="55171"/>
    <dbReference type="eggNOG" id="KOG4416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00470000042284"/>
    <dbReference type="HOGENOM" id="CLU_016712_1_1_1"/>
    <dbReference type="OMA" id="VPNAWDQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003499">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MYC2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000005">
        <property type="entry name" value="TBCC domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="290"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004928.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="557" mass="63461" checksum="32F00C4C8D784C4D" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZK5</accession>
    <name>A0A096MZK5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">EPHA4</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 35">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003908045.1">
        <property type="nucleotide sequence ID" value="XM_003907996.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZK5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005409"/>
    <dbReference type="Ensembl" id="ENSPANT00000006209.3">
        <property type="protein sequence ID" value="ENSPANP00000005409.1"/>
        <property type="gene ID" value="ENSPANG00000022149.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014934"/>
    <dbReference type="KEGG" id="panu:101014934"/>
    <dbReference type="CTD" id="2043"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156948"/>
    <dbReference type="HOGENOM" id="CLU_000288_141_4_1"/>
    <dbReference type="OMA" id="YDEHNGE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022149">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZK5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097161">
        <property type="term" value="F:DH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005004">
        <property type="term" value="F:GPI-linked ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042731">
        <property type="term" value="F:PH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="986" mass="109833" checksum="0C3FA60D750C175F" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N039</accession>
    <name>A0A096N039_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calmodulin like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CALML6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calmodulin family. Calglandulin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N039"/>
    <dbReference type="Ensembl" id="ENSPANT00000023216.3">
        <property type="protein sequence ID" value="ENSPANP00000005603.2"/>
        <property type="gene ID" value="ENSPANG00000000394.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163135"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_5_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000394">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 30 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N039">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000163">
        <property type="entry name" value="Calmodulin like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000264">
        <property type="entry name" value="Calmodulin like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF56">
        <property type="entry name" value="CALMODULIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005603.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="164" mass="18607" checksum="93B6558946A4AE6B" modified="2018-02-28" version="2">MGLQQEISLTERLSAEQIKEYKGVFEMFDEEGNGEVKTGELERLMSLLGINPTKSELASMAKDVDRDNKGFFNCDGFLALMGVYHEKAQNQESELRAAFRVFDKEGKGYIDWNTLKYVLMNAGEPLNEVEAEQMMKEADKDGDGTIDYEEFVAMMTGESFKLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N059</accession>
    <name>A0A096N059_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylosome protein WDR77</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methylosome protein 50</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein 77</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">WDR77</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the methylosome complex composed of PRMT5, WDR77 and CLNS1A. Found in a complex composed of PRMT5, WDR77 and RIOK1. RIOK1 and CLNS1A bound directly to PRMT5 at the same binding site, in a mutually exclusive manner, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively. Found in a complex with the component of the methylosome, PRMT5, CLNS1A, WDR77, PRMT1 and ERH. Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/H2AC20, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1. Interacts with CHTOP. Interacts with FAM47E. Interacts with TSC22D2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003892427.1">
        <property type="nucleotide sequence ID" value="XM_003892378.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N059"/>
    <dbReference type="SMR" id="A0A096N059"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005629"/>
    <dbReference type="Ensembl" id="ENSPANT00000027838.3">
        <property type="protein sequence ID" value="ENSPANP00000005629.2"/>
        <property type="gene ID" value="ENSPANG00000012473.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999972"/>
    <dbReference type="KEGG" id="panu:100999972"/>
    <dbReference type="CTD" id="79084"/>
    <dbReference type="eggNOG" id="KOG0284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010711"/>
    <dbReference type="HOGENOM" id="CLU_051285_0_0_1"/>
    <dbReference type="OMA" id="QMGCNAS"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012473">
        <property type="expression patterns" value="Expressed in gastrocnemius and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N059">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060767">
        <property type="term" value="P:epithelial cell proliferation involved in prostate gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060770">
        <property type="term" value="P:negative regulation of epithelial cell proliferation involved in prostate gland development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007309">
        <property type="term" value="P:oocyte axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060528">
        <property type="term" value="P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000322">
        <property type="entry name" value="Methylosome protein 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052139">
        <property type="entry name" value="Methylosome_Comp_WDR77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853:SF3">
        <property type="entry name" value="METHYLOSOME PROTEIN WDR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005629.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="342" mass="36830" checksum="4CCC0B1535A43128" modified="2018-02-28" version="2">MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVCVLSSGTQAVSGSKDFCIKVWDLAQQVVLNSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHIVPTEPLPAPGPASVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0D1</accession>
    <name>A0A096N0D1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain family member D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EFHD1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021779834.2">
        <property type="nucleotide sequence ID" value="XM_021924142.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0D1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005713"/>
    <dbReference type="Ensembl" id="ENSPANT00000020664.3">
        <property type="protein sequence ID" value="ENSPANP00000005713.3"/>
        <property type="gene ID" value="ENSPANG00000008052.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004601"/>
    <dbReference type="KEGG" id="panu:101004601"/>
    <dbReference type="CTD" id="80303"/>
    <dbReference type="eggNOG" id="KOG0041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012058"/>
    <dbReference type="HOGENOM" id="CLU_094429_0_0_1"/>
    <dbReference type="OMA" id="EVKHTYR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008052">
        <property type="expression patterns" value="Expressed in iris and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0D1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061891">
        <property type="term" value="F:calcium ion sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900069">
        <property type="term" value="P:regulation of cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000112">
        <property type="entry name" value="EF-hand domain family, member D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005713.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="235" mass="26518" checksum="03449B74A0819B73" modified="2022-05-25" version="3">MASEELARKLERRLRREEAEESGPQLAPLGAPAPESEPPARAPTASADAELSAQLSRRLDINEGAARPRRCRVFNPYTEFPEFSRRLIKDLESMFKLYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFLLIFHKAAAGELQEDSGLMALAKLSEINVALEGVKGAKNFFEAKVQALSLASKFEAELKAEQDERKREEEERRLRQAAFQELKANFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0R6</accession>
    <name>A0A096N0R6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LTN1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005854"/>
    <dbReference type="Ensembl" id="ENSPANT00000001476.3">
        <property type="protein sequence ID" value="ENSPANP00000005854.2"/>
        <property type="gene ID" value="ENSPANG00000015701.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016055"/>
    <dbReference type="HOGENOM" id="CLU_002412_0_0_1"/>
    <dbReference type="OMA" id="IYGSHWE"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015701">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0R6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001251">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056241">
        <property type="entry name" value="LTN1_HEAT_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24618">
        <property type="entry name" value="LTN1_E3_ligase_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1802"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005854.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1853" mass="209724" checksum="CE30834A75EDF676" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1P7</accession>
    <name>A0A096N1P7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP-3 complex subunit mu-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AP3M2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902737.1">
        <property type="nucleotide sequence ID" value="XM_003902688.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211227.1">
        <property type="nucleotide sequence ID" value="XM_009212963.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009211228.1">
        <property type="nucleotide sequence ID" value="XM_009212964.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017817467.1">
        <property type="nucleotide sequence ID" value="XM_017961978.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N1P7"/>
    <dbReference type="SMR" id="A0A096N1P7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006224"/>
    <dbReference type="Ensembl" id="ENSPANT00000000250.3">
        <property type="protein sequence ID" value="ENSPANP00000006224.1"/>
        <property type="gene ID" value="ENSPANG00000016689.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015842"/>
    <dbReference type="KEGG" id="panu:101015842"/>
    <dbReference type="CTD" id="10947"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157991"/>
    <dbReference type="HOGENOM" id="CLU_026996_6_2_1"/>
    <dbReference type="OMA" id="LIWNIGK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016689">
        <property type="expression patterns" value="Expressed in cerebellum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N1P7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09261">
        <property type="entry name" value="AP-3_Mu3B_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000012">
        <property type="entry name" value="AP-3 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000006">
        <property type="entry name" value="Putative AP-3 complex subunit mu-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="176"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="418" mass="46988" checksum="E3DD6A5144A44785" modified="2014-11-26" version="1">MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKPPNLKGTMSLQAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2M7</accession>
    <name>A0A096N2M7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-defensin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_017817977.1">
        <property type="nucleotide sequence ID" value="XM_017962488.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N2M7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006571"/>
    <dbReference type="Ensembl" id="ENSPANT00000007008.3">
        <property type="protein sequence ID" value="ENSPANP00000006571.1"/>
        <property type="gene ID" value="ENSPANG00000011031.3"/>
    </dbReference>
    <dbReference type="GeneID" id="108587425"/>
    <dbReference type="KEGG" id="panu:108587425"/>
    <dbReference type="eggNOG" id="ENOG502TEXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160995"/>
    <dbReference type="HOGENOM" id="CLU_191088_0_0_1"/>
    <dbReference type="OMA" id="TIGVCND"/>
    <dbReference type="OrthoDB" id="9542609at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011031">
        <property type="expression patterns" value="Expressed in gastrocnemius and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031731">
        <property type="term" value="F:CCR6 chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001855">
        <property type="entry name" value="Defensin_beta-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20515">
        <property type="entry name" value="BETA-DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20515:SF1">
        <property type="entry name" value="BETA-DEFENSIN 130A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00711">
        <property type="entry name" value="Defensin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57392">
        <property type="entry name" value="Defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0211">Defensin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001928553" description="Beta-defensin-like domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-defensin-like" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="79" mass="8768" checksum="343F71E6CD82635C" modified="2014-11-26" version="1">MKLHSLISVLLLFVTLIPKGKTGVIPGQKQCIVLKGVCRDKGCSTLDDTIGTCNEEKKCCRRWWILEPYPTPVPKGKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N3G1</accession>
    <name>A0A096N3G1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protein NEDD8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Neddylin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with AHR; interaction is direct. Interacts with NUB1; interaction is direct. Interacts with ESR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N3G1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006873"/>
    <dbReference type="Ensembl" id="ENSPANT00000010288.3">
        <property type="protein sequence ID" value="ENSPANP00000006873.2"/>
        <property type="gene ID" value="ENSPANG00000010368.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155856"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="ECKISDA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010368">
        <property type="expression patterns" value="Expressed in dorsal thalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006873.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="81" mass="9177" checksum="EE97406B67862DFB" modified="2022-05-25" version="2">MLIKVKTLTGEEIEIDIEPTEKVEWIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILSGSVLHLVLALRGGSGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7R1</accession>
    <name>A0A096N7R1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MFSD5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N7R1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008615"/>
    <dbReference type="Ensembl" id="ENSPANT00000014082.3">
        <property type="protein sequence ID" value="ENSPANP00000008615.3"/>
        <property type="gene ID" value="ENSPANG00000002873.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012629"/>
    <dbReference type="HOGENOM" id="CLU_034007_2_0_1"/>
    <dbReference type="OMA" id="CCGWVVL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002873">
        <property type="expression patterns" value="Expressed in esophagus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032094">
        <property type="term" value="P:response to food"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000192">
        <property type="entry name" value="Major facilitator superfamily domain-containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008615.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="556" mass="61211" checksum="7A5161F4E37FAE57" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEW6</accession>
    <name>A0A096NEW6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Interleukin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IL36RN</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the IL-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021780912.1">
        <property type="nucleotide sequence ID" value="XM_021925220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NEW6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011452"/>
    <dbReference type="Ensembl" id="ENSPANT00000010145.3">
        <property type="protein sequence ID" value="ENSPANP00000011452.1"/>
        <property type="gene ID" value="ENSPANG00000007246.3"/>
    </dbReference>
    <dbReference type="GeneID" id="110741124"/>
    <dbReference type="KEGG" id="panu:110741124"/>
    <dbReference type="CTD" id="26525"/>
    <dbReference type="eggNOG" id="ENOG502SRSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182943"/>
    <dbReference type="HOGENOM" id="CLU_095373_2_1_1"/>
    <dbReference type="OMA" id="IMELYAG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007246">
        <property type="expression patterns" value="Expressed in zone of skin and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005149">
        <property type="term" value="F:interleukin-1 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019732">
        <property type="term" value="P:antifungal humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002437">
        <property type="term" value="P:inflammatory response to antigenic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001960">
        <property type="term" value="P:negative regulation of cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032700">
        <property type="term" value="P:negative regulation of interleukin-17 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23303">
        <property type="entry name" value="beta-trefoil_IL36RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000013">
        <property type="entry name" value="Interleukin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020877">
        <property type="entry name" value="IL-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000975">
        <property type="entry name" value="IL-1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003297">
        <property type="entry name" value="IL-1RA/IL-36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078">
        <property type="entry name" value="INTERLEUKIN-1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078:SF32">
        <property type="entry name" value="INTERLEUKIN-36 RECEPTOR ANTAGONIST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00340">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00264">
        <property type="entry name" value="INTERLEUKIN1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01360">
        <property type="entry name" value="INTRLEUKIN1X"/>
    </dbReference>
    <dbReference type="SMART" id="SM00125">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00253">
        <property type="entry name" value="INTERLEUKIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="155" mass="16908" checksum="E13F2B870D866696" modified="2014-11-26" version="1">MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVILGVQGGSQCLSCGAGQEPTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAHPGWFLCTVPEADQPVRLTQLPDNAGWNAPITDFYFQQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NF31</accession>
    <name>A0A096NF31_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deoxyguanosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DGUOK</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyadenosine + ATP = dAMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.76"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyguanosine + ATP = dGMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19201"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908875.1">
        <property type="nucleotide sequence ID" value="XM_003908826.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NF31"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011519"/>
    <dbReference type="Ensembl" id="ENSPANT00000007559.3">
        <property type="protein sequence ID" value="ENSPANP00000011519.1"/>
        <property type="gene ID" value="ENSPANG00000006183.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012774"/>
    <dbReference type="KEGG" id="panu:101012774"/>
    <dbReference type="CTD" id="1716"/>
    <dbReference type="eggNOG" id="KOG4235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159627"/>
    <dbReference type="HOGENOM" id="CLU_030466_1_1_1"/>
    <dbReference type="OMA" id="QHEHWLV"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006183">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NF31">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004136">
        <property type="term" value="F:deoxyadenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106383">
        <property type="term" value="P:dAMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046070">
        <property type="term" value="P:dGTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046122">
        <property type="term" value="P:purine deoxyribonucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000461">
        <property type="entry name" value="Deoxycytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF8">
        <property type="entry name" value="DEOXYGUANOSINE KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="12">
        <location>
            <begin position="41"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="277" mass="32155" checksum="14C56A14428E6473" modified="2014-11-26" version="1">MAAGRLFLSRLRAPFSSMAQSLLEGVPFSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLAKTYPEWHVATEPVATWQDIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRLTLHGFIYLQASPQVCLKRLYRRAREEEKGIELAYLEQLHGQHEAWLLHKTTKLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFE7</accession>
    <name>A0A096NFE7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHPF2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003896932.1">
        <property type="nucleotide sequence ID" value="XM_003896883.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520876.1">
        <property type="nucleotide sequence ID" value="XM_031665016.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520877.1">
        <property type="nucleotide sequence ID" value="XM_031665017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NFE7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011643"/>
    <dbReference type="Ensembl" id="ENSPANT00000023160.3">
        <property type="protein sequence ID" value="ENSPANP00000011643.2"/>
        <property type="gene ID" value="ENSPANG00000026410.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101002908"/>
    <dbReference type="KEGG" id="panu:101002908"/>
    <dbReference type="CTD" id="54480"/>
    <dbReference type="eggNOG" id="KOG3708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244857"/>
    <dbReference type="HOGENOM" id="CLU_016244_1_0_1"/>
    <dbReference type="OMA" id="YLNRVRM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026410">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NFE7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050510">
        <property type="term" value="F:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000004">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF14">
        <property type="entry name" value="CHONDROITIN SULFATE GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014198175" description="Hexosyltransferase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011643.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="772" mass="85948" checksum="E0B75563CA4AC5BB" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHL9</accession>
    <name>A0A096NHL9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein ILRUN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ILRUN</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with IRF3; the interaction inhibits IRF3 binding to its DNA consensus sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_017813305.1">
        <property type="nucleotide sequence ID" value="XM_017957816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NHL9"/>
    <dbReference type="Ensembl" id="ENSPANT00000023009.3">
        <property type="protein sequence ID" value="ENSPANP00000012467.3"/>
        <property type="gene ID" value="ENSPANG00000020768.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101010451"/>
    <dbReference type="KEGG" id="panu:101010451"/>
    <dbReference type="CTD" id="64771"/>
    <dbReference type="GeneTree" id="ENSGT00490000043415"/>
    <dbReference type="OMA" id="HWQGSPN"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020768">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NHL9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050687">
        <property type="term" value="P:negative regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000015">
        <property type="entry name" value="Chromosome 6 C6orf106 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000289">
        <property type="entry name" value="Chromosome 6 open reading frame 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="11">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012467.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="298" mass="32858" checksum="3CA4E7F0B3D26D76" modified="2022-05-25" version="3">MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFVKTWRIQNSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLKDPGGSEFDSISKNSWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSHANNLSVVTYSKGLHGPYPFGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIT5</accession>
    <name>A0A096NIT5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tudor domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TDRD6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation. Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Found in a mRNP complex (i.e. messenger ribonucleoproteins which correspond to mRNA with bound proteins), at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at least composed of PIWIL1, PIWIL2, DDX4 and TDRD6. Interacts with Tex19.1 and probably Tex19.2. Interacts with PRMT5. Interacts with SNRPB (when methylated); to trigger spliceosome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003897743.1">
        <property type="nucleotide sequence ID" value="XM_003897694.5"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000012883"/>
    <dbReference type="Ensembl" id="ENSPANT00000004927.3">
        <property type="protein sequence ID" value="ENSPANP00000012883.2"/>
        <property type="gene ID" value="ENSPANG00000005761.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010818"/>
    <dbReference type="KEGG" id="panu:101010818"/>
    <dbReference type="CTD" id="221400"/>
    <dbReference type="eggNOG" id="KOG2039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159049"/>
    <dbReference type="HOGENOM" id="CLU_001126_1_0_1"/>
    <dbReference type="OMA" id="PWLLTQM"/>
    <dbReference type="OrthoDB" id="9989103at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005761">
        <property type="expression patterns" value="Expressed in testis and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NIT5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NJC7</accession>
    <name>A0A096NJC7_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">SON DNA and RNA binding protein</fullName>
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        <name evidence="2" type="primary">SON</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013076.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2203" mass="239785" checksum="2CC58209411DCDB4" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NJC8</accession>
    <name>A0A096NJC8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Engulfment and cell motility 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ELMO3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NJC8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013077"/>
    <dbReference type="Ensembl" id="ENSPANT00000004311.3">
        <property type="protein sequence ID" value="ENSPANP00000013077.3"/>
        <property type="gene ID" value="ENSPANG00000005501.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159455"/>
    <dbReference type="HOGENOM" id="CLU_023887_0_0_1"/>
    <dbReference type="OMA" id="KIAIQMM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005501">
        <property type="expression patterns" value="Expressed in cornea and 39 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NJC8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13359">
        <property type="entry name" value="PH_ELMO1_CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF16">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="358"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013077.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="771" mass="87043" checksum="DC25C8FFF5058BED" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLN5</accession>
    <name>A0A096NLN5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor NUBP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleotide-binding protein 1</fullName>
            <shortName evidence="11">NBP 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">NUBP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003916576.1">
        <property type="nucleotide sequence ID" value="XM_003916527.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLN5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013893"/>
    <dbReference type="Ensembl" id="ENSPANT00000022998.3">
        <property type="protein sequence ID" value="ENSPANP00000013893.1"/>
        <property type="gene ID" value="ENSPANG00000009723.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004084"/>
    <dbReference type="KEGG" id="panu:101004084"/>
    <dbReference type="CTD" id="4682"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183193"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OMA" id="VSGCPMR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009723">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010826">
        <property type="term" value="P:negative regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072697">
        <property type="term" value="P:protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="320" mass="34569" checksum="3470788F96A29B2E" modified="2014-11-26" version="1">MEEVPHDCPGADSAQAGRGTSCQGCPNQRLCASGAGATPDPAIEEIKEKMKTVKHKILVLSGKGGVGKSTFSAHLAHGLAEDENTQIALLDIDICGPSIPKIMGLEGEQVHQSGSGWSPVYVEDNLGVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDVDWGEVDYLIVDTPPGTSDEHLSVVQYLAAARIDGAVIITTPQEVSLQDVRKEINFCRKVKLPIIGVVENMSGFICPKCKKESQIFPPTTGGAELMCQDLEVPLLGRVPLDPLIGKNCDKGQSFFIDAPDSPATLAYRSIIQRIQEFCDLRQSEEENLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNZ3</accession>
    <name>A0A096NNZ3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ZXD family zinc finger C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZXDC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZXD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021789847.1">
        <property type="nucleotide sequence ID" value="XM_021934155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNZ3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014703"/>
    <dbReference type="Ensembl" id="ENSPANT00000001060.3">
        <property type="protein sequence ID" value="ENSPANP00000014703.3"/>
        <property type="gene ID" value="ENSPANG00000000433.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997636"/>
    <dbReference type="CTD" id="79364"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162216"/>
    <dbReference type="HOGENOM" id="CLU_007312_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000433">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000543">
        <property type="entry name" value="Zinc finger protein 384 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000872">
        <property type="entry name" value="zinc finger X-linked protein ZXDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000257">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000499">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001192">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="175"/>
            <end position="204"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="238"/>
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    <feature type="domain" description="C2H2-type" evidence="14">
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    <feature type="domain" description="C2H2-type" evidence="14">
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            <begin position="328"/>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="358"/>
            <end position="387"/>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="388"/>
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    <feature type="domain" description="C2H2-type" evidence="14">
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            <begin position="418"/>
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            <begin position="451"/>
            <end position="481"/>
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            <begin position="1"/>
            <end position="122"/>
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        <location>
            <begin position="149"/>
            <end position="174"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
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            <begin position="747"/>
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            <begin position="856"/>
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            <begin position="84"/>
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            <begin position="156"/>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053079"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061186"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="879" mass="92325" checksum="3A4C3E4F618BBD3B" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQM9</accession>
    <name>A0A096NQM9_PAPAN</name>
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        <submittedName>
            <fullName evidence="4">BICD family like cargo adaptor 1</fullName>
        </submittedName>
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        <name evidence="4" type="primary">BICDL1</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Quiroz J.Q."/>
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                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="expression patterns" value="Expressed in cornea and 60 other cell types or tissues"/>
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        <property type="term" value="P:Golgi to secretory granule transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
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        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
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        <location>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Papio anubis</name>
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            <taxon>Euteleostomi</taxon>
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    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
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                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
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                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
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                <person name="Hirani K.H."/>
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                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
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                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with HSPA5, HSP90B1, TUBULIN, UGGT1 and UGGT2. Interacts with TET3. Interacts with STPG4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the methyltransferase superfamily. METTL23 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003913547.2">
        <property type="nucleotide sequence ID" value="XM_003913498.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031513661.1">
        <property type="nucleotide sequence ID" value="XM_031657801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NT48"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016219"/>
    <dbReference type="Ensembl" id="ENSPANT00000006064.3">
        <property type="protein sequence ID" value="ENSPANP00000016219.2"/>
        <property type="gene ID" value="ENSPANG00000020022.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998486"/>
    <dbReference type="KEGG" id="panu:100998486"/>
    <dbReference type="CTD" id="124512"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048008"/>
    <dbReference type="HOGENOM" id="CLU_082022_1_0_1"/>
    <dbReference type="OMA" id="VIGITWG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020022">
        <property type="expression patterns" value="Expressed in metanephros cortex and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NT48">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035642">
        <property type="term" value="F:histone H3R17 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044727">
        <property type="term" value="P:epigenetic programing of male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000173">
        <property type="entry name" value="methyltransferase-like protein 23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF164">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE METTL23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016219.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="190" mass="21432" checksum="1EE0DC4DDFF88112" modified="2018-02-28" version="2">MYVWPCAVVLAQYLWFHRRSLPGKAILEIGAGVSLPGILAAKCGAEVILSDSSELPHCLEVCRQSCQMNNLPQLQVVGLTWGHVSWDLLALPPQDIILASDVFFEPEDFEDILTTVYFLMHKNPKVQLWSTYQVRSADWSLEALLYKWDMKCVHIPLESFDADKEDIAESALPGRHTVEMLVISFAKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NT98</accession>
    <name>A0A096NT98_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ectonucleotide pyrophosphatase/phosphodiesterase family member 7</fullName>
            <ecNumber evidence="3">3.1.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Alkaline sphingomyelin phosphodiesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Intestinal alkaline sphingomyelinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ENPP7</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52450"/>
            <dbReference type="ChEBI" id="CHEBI:147296"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63380"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16291"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:63381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A096NT98"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016269"/>
    <dbReference type="Ensembl" id="ENSPANT00000010697.3">
        <property type="protein sequence ID" value="ENSPANP00000016269.1"/>
        <property type="gene ID" value="ENSPANG00000019832.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159339"/>
    <dbReference type="HOGENOM" id="CLU_017594_1_0_1"/>
    <dbReference type="OMA" id="IAHNYKN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019832">
        <property type="expression patterns" value="Expressed in spleen"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006684">
        <property type="term" value="P:sphingomyelin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000005">
        <property type="entry name" value="ectonucleotide pyrophosphatase/phosphodiesterase family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000048">
        <property type="entry name" value="ectonucleotide pyrophosphatase/phosphodiesterase family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF63">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922735" description="Ectonucleotide pyrophosphatase/phosphodiesterase family member 7" evidence="21">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="458" mass="51288" checksum="48C99F457135ED81" modified="2014-11-26" version="1">MRGPAILLTVALATLLAPGAGAPVQSQGSRNKLLLVSFDGFRWNYDQDVDTPSLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFAEEDLDLVTLYFGEPDSTGHKYGPESPERREMVRQVDRTVGYLRESIARNHLTDHLNLIITSDHGMTTVDKQAGDLVEFHKFPNFTFQDIKFELLDYGPNGMLLPKEGRLEKVYNALKDAHPKLHVYKKEEFPEAFHYASNPRVTPLLMYSDLGYVIHGRVNVQFNNGEHGFDNKDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCRLLGIVPEANDGDPATLLPMLHTESALPPDGRPALPLNGRSAVLPSSWALVVMGLLGTMILLSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUW8</accession>
    <name>A0A096NUW8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MAP4K5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A096NUW8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016843"/>
    <dbReference type="Ensembl" id="ENSPANT00000013608.4">
        <property type="protein sequence ID" value="ENSPANP00000016843.2"/>
        <property type="gene ID" value="ENSPANG00000009733.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158072"/>
    <dbReference type="HOGENOM" id="CLU_006347_1_0_1"/>
    <dbReference type="OMA" id="XQYIIFG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009733">
        <property type="expression patterns" value="Expressed in optic disc and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUW8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06646">
        <property type="entry name" value="STKc_MAP4K5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF19">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="17">
        <location>
            <begin position="506"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="373"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016843.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="846" mass="95111" checksum="B4516A0C3BA5E6C9" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NV66</accession>
    <name>A0A096NV66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proenkephalin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-neoendorphin-dynorphin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Preprodynorphin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDYN</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Leumorphin has a typical opioid activity and may have anti-apoptotic effect.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the opioid neuropeptide precursor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905016.1">
        <property type="nucleotide sequence ID" value="XM_003904967.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214709.1">
        <property type="nucleotide sequence ID" value="XM_009216445.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214710.1">
        <property type="nucleotide sequence ID" value="XM_009216446.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214711.1">
        <property type="nucleotide sequence ID" value="XM_009216447.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017800439.1">
        <property type="nucleotide sequence ID" value="XM_017944950.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NV66"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016941"/>
    <dbReference type="Ensembl" id="ENSPANT00000064343.1">
        <property type="protein sequence ID" value="ENSPANP00000058255.1"/>
        <property type="gene ID" value="ENSPANG00000045629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101015738"/>
    <dbReference type="KEGG" id="panu:101015738"/>
    <dbReference type="CTD" id="5173"/>
    <dbReference type="eggNOG" id="ENOG502RXT4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183149"/>
    <dbReference type="OMA" id="CSMCAVQ"/>
    <dbReference type="OrthoDB" id="8912385at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016041">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098992">
        <property type="term" value="C:neuronal dense core vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001515">
        <property type="term" value="F:opioid peptide activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031628">
        <property type="term" value="F:opioid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006024">
        <property type="entry name" value="Opioid_neupept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000750">
        <property type="entry name" value="Proenkphlin_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11438">
        <property type="entry name" value="PROENKEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11438:SF4">
        <property type="entry name" value="PROENKEPHALIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01160">
        <property type="entry name" value="Opiods_neuropep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01028">
        <property type="entry name" value="OPIOIDPRCRSR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01030">
        <property type="entry name" value="PENKBPRCRSR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01252">
        <property type="entry name" value="OPIOIDS_PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0257">Endorphin</keyword>
    <keyword evidence="11 17" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="7" id="KW-0529">Neurotransmitter</keyword>
    <keyword evidence="8 17" id="KW-0555">Opioid peptide</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="253" mass="28011" checksum="D2174D2E80FADC4F" modified="2014-11-26" version="1">MTWQGLVLAACLLVFPSATADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSDEWERCQSFLSFFTPSTLGLNDKGDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTENTLSKTLEEKLRGLSGGFGEGAESELMRDAQLNNGAMETGTLDFTEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWI7</accession>
    <name>A0A096NWI7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin-24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CDH24</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with alpha-, beta- and delta-catenins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003901628.1">
        <property type="nucleotide sequence ID" value="XM_003901579.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209438.1">
        <property type="nucleotide sequence ID" value="XM_009211174.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209439.1">
        <property type="nucleotide sequence ID" value="XM_009211175.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796700.1">
        <property type="nucleotide sequence ID" value="XM_021941008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWI7"/>
    <dbReference type="Ensembl" id="ENSPANT00000012949.3">
        <property type="protein sequence ID" value="ENSPANP00000017415.1"/>
        <property type="gene ID" value="ENSPANG00000019643.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998740"/>
    <dbReference type="KEGG" id="panu:100998740"/>
    <dbReference type="CTD" id="64403"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159567"/>
    <dbReference type="HOGENOM" id="CLU_005284_3_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019643">
        <property type="expression patterns" value="Expressed in cornea and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWI7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000179">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000010">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF272">
        <property type="entry name" value="CADHERIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001923332" description="Cadherin-24" evidence="20">
        <location>
            <begin position="17"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="151"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="260"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="375"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="479"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="731"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="781" mass="83912" checksum="330E211ED2644E30" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWM7</accession>
    <name>A0A096NWM7_PAPAN</name>
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        <submittedName>
            <fullName evidence="6">NMDA receptor synaptonuclear signaling and neuronal migration factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NSMF</name>
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    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009186015.1">
        <property type="nucleotide sequence ID" value="XM_009187751.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWM7"/>
    <dbReference type="SMR" id="A0A096NWM7"/>
    <dbReference type="Ensembl" id="ENSPANT00000028878.3">
        <property type="protein sequence ID" value="ENSPANP00000017455.2"/>
        <property type="gene ID" value="ENSPANG00000026434.3"/>
    </dbReference>
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    <dbReference type="KEGG" id="panu:101000911"/>
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    <dbReference type="eggNOG" id="ENOG502QRME">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 13"/>
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    <dbReference type="Bgee" id="ENSPANG00000026434">
        <property type="expression patterns" value="Expressed in amygdala and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWM7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001222">
        <property type="term" value="P:regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058542">
        <property type="entry name" value="IQ_SCN5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033374">
        <property type="entry name" value="NSMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32061">
        <property type="entry name" value="NMDA RECEPTOR SYNAPTONUCLEAR SIGNALING AND NEURONAL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IQ_SCN5A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="247"/>
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        </location>
    </feature>
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        <location>
            <begin position="34"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
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        </location>
    </feature>
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        <location>
            <begin position="285"/>
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    </feature>
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        <location>
            <begin position="38"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="125"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24609"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017455.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWZ1</accession>
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            <fullName evidence="4">Protachykinin-1</fullName>
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            <fullName evidence="11">PPT</fullName>
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        <name evidence="14" type="primary">TAC1</name>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tachykinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896336.1">
        <property type="nucleotide sequence ID" value="XM_003896287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWZ1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037577"/>
    <dbReference type="Ensembl" id="ENSPANT00000007558.3">
        <property type="protein sequence ID" value="ENSPANP00000017581.1"/>
        <property type="gene ID" value="ENSPANG00000005012.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024050"/>
    <dbReference type="KEGG" id="panu:101024050"/>
    <dbReference type="CTD" id="6863"/>
    <dbReference type="eggNOG" id="ENOG502S1KJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002457"/>
    <dbReference type="HOGENOM" id="CLU_149426_0_0_1"/>
    <dbReference type="OMA" id="GQMSHKR"/>
    <dbReference type="OrthoDB" id="9936276at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005012">
        <property type="expression patterns" value="Expressed in putamen and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWZ1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0031835">
        <property type="term" value="F:substance P receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048265">
        <property type="term" value="P:response to pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007217">
        <property type="term" value="P:tachykinin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013055">
        <property type="entry name" value="Tachy_Neuro_lke_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008215">
        <property type="entry name" value="Tachykinin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008216">
        <property type="entry name" value="Tachykinin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11250:SF3">
        <property type="entry name" value="PROTACHYKININ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11250">
        <property type="entry name" value="TACHYKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02202">
        <property type="entry name" value="Tachykinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01829">
        <property type="entry name" value="PROTACHYKNIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00203">
        <property type="entry name" value="TK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00267">
        <property type="entry name" value="TACHYKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0027">Amidation</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10 12" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="9" id="KW-0529">Neurotransmitter</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Tachykinin" evidence="13">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Tachykinin" evidence="13">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="129" mass="14945" checksum="2993BD3DD287C25A" modified="2014-11-26" version="1">MKILVALAVFFLVSTQLFAEEMGANDDLNYWSDWSDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYV0</accession>
    <name>A0A096NYV0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">OTU domain-containing protein 7B</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cellular zinc finger anti-NF-kappa-B protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc finger A20 domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc finger protein Cezanne</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">OTUD7B</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003892608.2">
        <property type="nucleotide sequence ID" value="XM_003892559.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178512.2">
        <property type="nucleotide sequence ID" value="XM_009180248.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017802219.2">
        <property type="nucleotide sequence ID" value="XM_017946730.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYV0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018266"/>
    <dbReference type="MEROPS" id="C64.001"/>
    <dbReference type="Ensembl" id="ENSPANT00000001653.3">
        <property type="protein sequence ID" value="ENSPANP00000018266.2"/>
        <property type="gene ID" value="ENSPANG00000009169.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007965"/>
    <dbReference type="KEGG" id="panu:101007965"/>
    <dbReference type="CTD" id="56957"/>
    <dbReference type="eggNOG" id="KOG4345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159172"/>
    <dbReference type="HOGENOM" id="CLU_013263_0_0_1"/>
    <dbReference type="OMA" id="GSECQNG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009169">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002385">
        <property type="term" value="P:mucosal immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032717">
        <property type="term" value="P:negative regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="OTU domain-containing protein 7A"/>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <property type="entry name" value="Znf_A20"/>
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        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
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        <property type="entry name" value="zf-A20"/>
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            <begin position="183"/>
            <end position="365"/>
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            <begin position="796"/>
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            <begin position="50"/>
            <end position="87"/>
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        <location>
            <begin position="442"/>
            <end position="587"/>
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        <location>
            <begin position="652"/>
            <end position="711"/>
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        <location>
            <begin position="734"/>
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            <begin position="65"/>
            <end position="77"/>
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        <location>
            <begin position="456"/>
            <end position="471"/>
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        <location>
            <begin position="488"/>
            <end position="500"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="531"/>
            <end position="543"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="665"/>
            <end position="675"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00070807"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00076964"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00077079"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081736"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00451"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51036"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018266.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="843" mass="92442" checksum="067C09F5482B91F7" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYW3</accession>
    <name>A0A096NYW3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 1 open reading frame 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C1orf52</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0690 family.</text>
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        <property type="component" value="Chromosome 1"/>
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        <property type="expression patterns" value="Expressed in Ammon's horn and 66 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029089">
        <property type="entry name" value="DUF4660"/>
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        <property type="entry name" value="UPF0690 PROTEIN C1ORF52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31833:SF2">
        <property type="entry name" value="UPF0690 PROTEIN C1ORF52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15559">
        <property type="entry name" value="DUF4660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="64"/>
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            <begin position="22"/>
            <end position="32"/>
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            <begin position="50"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008407"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="182" mass="20673" checksum="B541F025236C2E70" modified="2014-11-26" version="1">MAAEEKDPLSYFAAYGSSSSDSSDEEDNIEPEETSRRTPDLAKSAGGCRNKAEKRLPGPDELFRSVTRPAFLYNPLNKQIDWERHVVKAPEEPPKEFKIWKSNYVPPPETYTTEKKPPPPELDMAIKWSNIYEDNGDDAPQNAKKARLLPEGEETLESDDEKDEHTSKKRKVEPGEPAKKKK</sequence>
</entry>
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    <name>A0A096P0J6_PAPAN</name>
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        <submittedName>
            <fullName evidence="19">Ceramide synthase 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="19" type="primary">CERS4</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12 14">Nucleus</location>
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    <dbReference type="AlphaFoldDB" id="A0A096P0J6"/>
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        <property type="gene ID" value="ENSPANG00000025898.3"/>
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    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
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    <dbReference type="Bgee" id="ENSPANG00000025898">
        <property type="expression patterns" value="Expressed in pineal body and 64 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
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        <property type="term" value="P:ceramide biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Lag1/Lac1-like"/>
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        <property type="entry name" value="TLC-dom"/>
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        <property type="entry name" value="TRAM_LAG1_CLN8"/>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="140"/>
            <end position="160"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="257"/>
            <end position="279"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="17">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="18">
        <location>
            <begin position="131"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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            <dbReference type="ARBA" id="ARBA00004760"/>
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            <dbReference type="RuleBase" id="RU000682"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
    <sequence length="393" mass="46310" checksum="2659017A6CE0739B" modified="2022-05-25" version="2">MLSSFNEWLWQHRFWLPPNVTWAELEDRDGRVYPHPQDMLAALPLALVLLAMRLAFERFIGLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAARCGLTLRQTQRWFRRRRKQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWENYPNQTLKPSLYWWYLLELAFYLSLLIRLPFDVKRKDFKEQVIHHFVVVILMTFSYSANLLRIGSLVLLLHDSADYLLEACKMVNYTQYQHVCDALFLIFSLVFFYTRLVLFPTQILYTTYYESLGNRGPFFGYYFCNGLLMLLQLLHVFWSCLILRMLCSFIKKGQMEKDIRSDVEESDSSEEEEAGAQEPLQLKNGAARGPRPAPTDGLRSRVAGRNRHTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1W2</accession>
    <name>A0A096P1W2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC28A3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P1W2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019337"/>
    <dbReference type="Ensembl" id="ENSPANT00000025073.3">
        <property type="protein sequence ID" value="ENSPANP00000019337.2"/>
        <property type="gene ID" value="ENSPANG00000024883.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016025"/>
    <dbReference type="HOGENOM" id="CLU_016813_3_0_1"/>
    <dbReference type="OMA" id="ERKYDTV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
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    <dbReference type="Bgee" id="ENSPANG00000024883">
        <property type="expression patterns" value="Expressed in pancreas and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015390">
        <property type="term" value="F:purine-specific nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015389">
        <property type="term" value="F:pyrimidine- and adenosine-specific:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015213">
        <property type="term" value="F:uridine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0015860">
        <property type="term" value="P:purine nucleoside transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="286"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="389"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="692" mass="77012" checksum="2B8CA7729A60BDCA" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P291</accession>
    <name>A0A096P291_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoredoxin</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NXN</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A096P291"/>
    <dbReference type="Ensembl" id="ENSPANT00000024332.3">
        <property type="protein sequence ID" value="ENSPANP00000019466.3"/>
        <property type="gene ID" value="ENSPANG00000024614.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161894"/>
    <dbReference type="HOGENOM" id="CLU_019626_2_0_1"/>
    <dbReference type="OMA" id="NAPCRQF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024614">
        <property type="expression patterns" value="Expressed in aorta and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P291">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03071">
        <property type="entry name" value="PDI_b'_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03009">
        <property type="entry name" value="TryX_like_TryX_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000062">
        <property type="entry name" value="Nucleoredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000064">
        <property type="entry name" value="Nucleoredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041861">
        <property type="entry name" value="NRX_PDI_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045870">
        <property type="entry name" value="TryX_NRX_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="59"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019466.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="327" mass="36759" checksum="77D6E58098B7DF9B" modified="2022-05-25" version="3">TVDASLPRNRATLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQSFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIVLDPQGEVITRQGRVEVLNDEDCRGFPWHPKPVLELSDSNATQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2T6</accession>
    <name>A0A096P2T6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Period circadian regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PER1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021784409.1">
        <property type="nucleotide sequence ID" value="XM_021928717.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000019661"/>
    <dbReference type="Ensembl" id="ENSPANT00000022977.3">
        <property type="protein sequence ID" value="ENSPANP00000019661.2"/>
        <property type="gene ID" value="ENSPANG00000023840.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017574"/>
    <dbReference type="CTD" id="5187"/>
    <dbReference type="eggNOG" id="KOG3753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159217"/>
    <dbReference type="HOGENOM" id="CLU_006667_1_0_1"/>
    <dbReference type="OMA" id="GCTGCKC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023840">
        <property type="expression patterns" value="Expressed in aorta and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P2T6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000323">
        <property type="term" value="P:negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042634">
        <property type="term" value="P:regulation of hair cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051591">
        <property type="term" value="P:response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000013">
        <property type="entry name" value="Period circadian protein homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000004">
        <property type="entry name" value="Period circadian protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057310">
        <property type="entry name" value="PER1-3_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048814">
        <property type="entry name" value="Per1-3_PAS-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF8">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23170">
        <property type="entry name" value="bHLH_PER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21353">
        <property type="entry name" value="Per3-like_PAS-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="698"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="805"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="938"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="38"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1236"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019661.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1292" mass="136681" checksum="78BFA0FC29F1F252" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P373</accession>
    <name>A0A096P373_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">KSR1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A096P373"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019798"/>
    <dbReference type="Ensembl" id="ENSPANT00000022047.3">
        <property type="protein sequence ID" value="ENSPANP00000019798.3"/>
        <property type="gene ID" value="ENSPANG00000023544.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156066"/>
    <dbReference type="HOGENOM" id="CLU_006812_0_0_1"/>
    <dbReference type="OMA" id="TWRGPIS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023544">
        <property type="expression patterns" value="Expressed in esophagus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P373">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20872">
        <property type="entry name" value="C1_KSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14152">
        <property type="entry name" value="STKc_KSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000107">
        <property type="entry name" value="kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000034">
        <property type="entry name" value="Kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000031">
        <property type="entry name" value="Kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000010">
        <property type="entry name" value="Putative kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046861">
        <property type="entry name" value="SAM_KSR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046933">
        <property type="entry name" value="SAM_KSR1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF716">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20406">
        <property type="entry name" value="SAM_KSR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="347"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="591"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="174"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019798.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="928" mass="103074" checksum="BFC811AF9B4D454A" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3Y2</accession>
    <name>A0A096P3Y2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 17 open reading frame 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C17orf50</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096P3Y2"/>
    <dbReference type="Ensembl" id="ENSPANT00000020804.3">
        <property type="protein sequence ID" value="ENSPANP00000020057.3"/>
        <property type="gene ID" value="ENSPANG00000022929.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SXTN">
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    <dbReference type="OMA" id="HCVLEHP"/>
    <dbReference type="Proteomes" id="UP000028761">
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    <dbReference type="PANTHER" id="PTHR37878:SF1">
        <property type="entry name" value="DUF4637 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37878">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC689039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15470">
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020057.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="174" mass="19355" checksum="517AFA57B665F371" modified="2022-05-25" version="3">MDKHGVKTPLWKKEPEEPRAEEAEEEGKEGSEDEDEDEDNQRPPEESAAEGEEPPREAEEGEGRERRSVSYCPLRQESSTQQVALLRRADSGFWGWLGPLALLGGLTAPTDRKRSLPEEPCVLEIRRRPPRRGGCCCEILFCKKCRSLHSHPAYVAHCVLDHPDLGKAGAAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P462</accession>
    <name>A0A096P462_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Distal-less homeobox 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DLX4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
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                <person name="Thornton R.T."/>
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                <person name="Usmani K.U."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the distal-less homeobox family.</text>
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    <dbReference type="Ensembl" id="ENSPANT00000019646.3">
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        <property type="gene ID" value="ENSPANG00000022817.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001852"/>
    <dbReference type="KEGG" id="panu:101001852"/>
    <dbReference type="CTD" id="1748"/>
    <dbReference type="eggNOG" id="KOG0850">
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    <dbReference type="GeneTree" id="ENSGT00940000162259"/>
    <dbReference type="HOGENOM" id="CLU_074733_2_1_1"/>
    <dbReference type="OMA" id="GNNFGAW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022817">
        <property type="expression patterns" value="Expressed in pineal body and 1 other cell type or tissue"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000295">
        <property type="entry name" value="Distal-less homeobox 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF21">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020137.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="241" mass="26428" checksum="BE3FFB3A5B696785" modified="2022-05-25" version="2">MTSLPCPLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAASPNLSYSRPYGHLLSYPYTEPANPGDSYLPCQQPAALSQPLCGPAEHPQEREAKDSEKPRPSPEPSERRPQAPAKKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQNSGGQEGDFPGRTFSVSPCSPPLPSLWDLPKAGTLPTSGYGNSFGAWYQHHSSDVLASPQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P6J6</accession>
    <name>A0A096P6J6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sortilin related VPS10 domain containing receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SORCS1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P6J6"/>
    <dbReference type="Ensembl" id="ENSPANT00000028213.3">
        <property type="protein sequence ID" value="ENSPANP00000020971.2"/>
        <property type="gene ID" value="ENSPANG00000020876.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234563"/>
    <dbReference type="HOGENOM" id="CLU_010702_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020876">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 48 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P6J6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000001">
        <property type="entry name" value="Sortilin related VPS10 domain containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000083">
        <property type="entry name" value="Sortilin-related VPS10 domain containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF8">
        <property type="entry name" value="VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="11">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="901"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020971.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="937" mass="105713" checksum="9C17533491056B52" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUS6</accession>
    <name>A0A0A0MUS6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Keratinocyte differentiation associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KRTDAP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003915396.1">
        <property type="nucleotide sequence ID" value="XM_003915347.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUS6"/>
    <dbReference type="SMR" id="A0A0A0MUS6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003323"/>
    <dbReference type="Ensembl" id="ENSPANT00000021566.3">
        <property type="protein sequence ID" value="ENSPANP00000003323.1"/>
        <property type="gene ID" value="ENSPANG00000002972.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006409"/>
    <dbReference type="KEGG" id="panu:101006409"/>
    <dbReference type="CTD" id="388533"/>
    <dbReference type="eggNOG" id="ENOG502STEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009097"/>
    <dbReference type="HOGENOM" id="CLU_183149_0_0_1"/>
    <dbReference type="OMA" id="WRSAFQS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002972">
        <property type="expression patterns" value="Expressed in zone of skin and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042599">
        <property type="term" value="C:lamellar body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028196">
        <property type="entry name" value="KRTDAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36463">
        <property type="entry name" value="KERATINOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36463:SF1">
        <property type="entry name" value="KERATINOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15200">
        <property type="entry name" value="KRTDAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001974253" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="99" mass="11050" checksum="0F966EC142C89838" modified="2015-01-07" version="1">MKIPVLPAVVLLSLLVLHSAQGATLGGPEEESTIENYASRPEAFNTPFLNIDKLRSAFKADEFLNWHALFESIKRKLPFLNWDAFPKLKGLRSATPDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUY3</accession>
    <name>A0A0A0MUY3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transforming growth factor beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TGFB1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 16">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915631.1">
        <property type="nucleotide sequence ID" value="XM_003915582.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUY3"/>
    <dbReference type="SMR" id="A0A0A0MUY3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004153"/>
    <dbReference type="Ensembl" id="ENSPANT00000012070.3">
        <property type="protein sequence ID" value="ENSPANP00000004153.1"/>
        <property type="gene ID" value="ENSPANG00000010720.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006627"/>
    <dbReference type="KEGG" id="panu:101006627"/>
    <dbReference type="CTD" id="7040"/>
    <dbReference type="eggNOG" id="KOG3900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160457"/>
    <dbReference type="HOGENOM" id="CLU_039840_0_0_1"/>
    <dbReference type="OMA" id="SHNCCLK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010720">
        <property type="expression patterns" value="Expressed in aorta and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005160">
        <property type="term" value="F:transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19384">
        <property type="entry name" value="TGF_beta_TGFB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000004">
        <property type="entry name" value="Transforming growth factor beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.970:FF:000010">
        <property type="entry name" value="Transforming growth factor beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016319">
        <property type="entry name" value="TGF-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003939">
        <property type="entry name" value="TGFb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF125">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001787">
        <property type="entry name" value="TGF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01423">
        <property type="entry name" value="TGFBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01424">
        <property type="entry name" value="TGFBETA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14 16" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12 14" id="KW-0497">Mitogen</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016195927" description="Transforming growth factor beta" evidence="14">
        <location>
            <begin position="30"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="17">
        <location>
            <begin position="275"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="322"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="15">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR001787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001787-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="390" mass="44297" checksum="6FB76D1928B0A08E" modified="2015-01-07" version="1">MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSKDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LML1</accession>
    <name>A0A2I3LML1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 47 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM47A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM47 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LML1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024662"/>
    <dbReference type="Ensembl" id="ENSPANT00000032982.2">
        <property type="protein sequence ID" value="ENSPANP00000024662.2"/>
        <property type="gene ID" value="ENSPANG00000034376.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163970"/>
    <dbReference type="OMA" id="ICGRDEF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034376">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032743">
        <property type="entry name" value="FAM47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47415:SF4">
        <property type="entry name" value="PROTEIN FAM47A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47415">
        <property type="entry name" value="PROTEIN FAM47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14642">
        <property type="entry name" value="FAM47"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024662.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="707" mass="80899" checksum="C0DF2882873F261D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LPS8</accession>
    <name>A0A2I3LPS8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine zipper protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LUZP1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 1"/>
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    <accession>A0A2I3LPU1</accession>
    <name>A0A2I3LPU1_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Pancreatic progenitor cell differentiation and proliferation factor like</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">PPDPFL</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPDPF family.</text>
    </comment>
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        <property type="gene ID" value="ENSPANG00000017056.3"/>
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    <dbReference type="OMA" id="DKCWWIK"/>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="Bgee" id="ENSPANG00000017056">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 38 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3LPU1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026754">
        <property type="entry name" value="PPDPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14572">
        <property type="entry name" value="PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15060">
        <property type="entry name" value="PPDFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02071">
        <property type="entry name" value="PPDPFACTOR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="84" mass="9232" checksum="A6F6479D24471E0E" modified="2018-02-28" version="1">MASVPSIGCLLARNQYYRKSSVSSVSSLTGSDSINFIDDDKSQQGLPEVAESTWWFKFFFHSEPVLSNVRTKDLSAIGSLSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LPZ1</accession>
    <name>A0A2I3LPZ1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endothelial differentiation-related factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Multiprotein-bridging factor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003911109.1">
        <property type="nucleotide sequence ID" value="XM_003911060.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031517059.1">
        <property type="nucleotide sequence ID" value="XM_031661199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LPZ1"/>
    <dbReference type="SMR" id="A0A2I3LPZ1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000025530"/>
    <dbReference type="Ensembl" id="ENSPANT00000044157.2">
        <property type="protein sequence ID" value="ENSPANP00000025530.2"/>
        <property type="gene ID" value="ENSPANG00000026162.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000080366.1">
        <property type="protein sequence ID" value="ENSPANP00000049545.1"/>
        <property type="gene ID" value="ENSPANG00000048414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101018527"/>
    <dbReference type="GeneID" id="116272438"/>
    <dbReference type="KEGG" id="panu:101018527"/>
    <dbReference type="KEGG" id="panu:116272438"/>
    <dbReference type="CTD" id="8721"/>
    <dbReference type="GeneTree" id="ENSGT00390000008519"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026162">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LPZ1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025530.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="148" mass="16369" checksum="ADC2C5384BF85C11" modified="2022-05-25" version="2">MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LU20</accession>
    <name>A0A2I3LU20_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TGM3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3LU20"/>
    <dbReference type="Ensembl" id="ENSPANT00000040420.2">
        <property type="protein sequence ID" value="ENSPANP00000026949.2"/>
        <property type="gene ID" value="ENSPANG00000021244.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021244">
        <property type="expression patterns" value="Expressed in esophagus and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000278">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF36">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="10">
        <location>
            <begin position="265"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026949.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="693" mass="76820" checksum="EF0CBE3A4DE40CBF" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M4M1</accession>
    <name>A0A2I3M4M1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase Topors</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase Topors</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">SUMO1-protein E3 ligase Topors</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Topoisomerase I-binding RING finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Topoisomerase I-binding arginine/serine-rich protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Tumor suppressor p53-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TOPORS</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003911665.1">
        <property type="nucleotide sequence ID" value="XM_003911616.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M4M1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000030667"/>
    <dbReference type="Ensembl" id="ENSPANT00000042838.2">
        <property type="protein sequence ID" value="ENSPANP00000030667.2"/>
        <property type="gene ID" value="ENSPANG00000025293.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997419"/>
    <dbReference type="KEGG" id="panu:100997419"/>
    <dbReference type="CTD" id="10210"/>
    <dbReference type="GeneTree" id="ENSGT00530000064170"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025293">
        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M4M1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000136">
        <property type="entry name" value="E3 ubiquitin-protein ligase Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058745">
        <property type="entry name" value="PWI_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26084">
        <property type="entry name" value="PWI_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="511"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="713"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
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            <end position="534"/>
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            <begin position="731"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076856"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076940"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079184"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030667.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119146" checksum="A69AE362EC5567DA" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7N9</accession>
    <name>A0A2I3M7N9_PAPAN</name>
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        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
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        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
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        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_031660440.1"/>
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        <property type="protein sequence ID" value="ENSPANP00000031659.2"/>
        <property type="gene ID" value="ENSPANG00000030436.2"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="expression patterns" value="Expressed in testis"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Olfactory receptor"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="7tm_4"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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            <end position="63"/>
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            <dbReference type="RuleBase" id="RU363047"/>
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            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031659.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="321" mass="35901" checksum="D299938D55A6AED5" modified="2022-05-25" version="2">MNVSDVICFDILVSAMKAENQSFGTDFLLVGLFQYGWTNSLLFVVIATIFTVALTGNIMLIHLIRLDTRLHTPMYFLLSQLSMIDLMYISTTVPKMAVNFLSQSKTITFMGCEIQAYVFLALGGTEALLLGFMSYDRYVAICYPLHYPILMSKKICCLMVACAWASGSINAFIHTMYVFQLPFCRSRLINHFFCEIPALMSLVCQDTSHYEYTVLLSGLIILLLPFLAILASYARVLIVVFQMSSGKGQAKAVSTCSSHLIVASLFYATTLATYTKPHSLRSPTRDKVVAVFYTIMTPLLNPFIYSLQNKEVAGAMRRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M8E3</accession>
    <name>A0A2I3M8E3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SHOX homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SHOX2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M8J4</accession>
    <name>A0A2I3M8J4_PAPAN</name>
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            <fullName evidence="12">Ubiquitin thioesterase OTU</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with VCP; the interaction is direct. Interacts with FAF2/UBXD8. Interacts with DERL1; however interaction is dependent on the UBAX-like region, suggesting that it may be indirect. Interacts with PLAA, UBXN6 and VCP; may form a complex involved in macroautophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3M8J4"/>
    <dbReference type="Ensembl" id="ENSPANT00000036914.2">
        <property type="protein sequence ID" value="ENSPANP00000032072.1"/>
        <property type="gene ID" value="ENSPANG00000015345.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009989"/>
    <dbReference type="OMA" id="TRCILVY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015345">
        <property type="expression patterns" value="Expressed in esophagus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M8J4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904153">
        <property type="term" value="P:negative regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990167">
        <property type="term" value="P:protein K27-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035523">
        <property type="term" value="P:protein K29-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990168">
        <property type="term" value="P:protein K33-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000006">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0834">Unfolded protein response</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="304" mass="33949" checksum="FE27964ACCFB5959" modified="2018-02-28" version="1">IETLHIIYSEAKSFTVEGLSSRTRVRELQSQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIVEEDQTRPKSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M943</accession>
    <name>A0A2I3M943_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid phosphatase-related protein type 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Inactive 2-lysophosphatidate phosphatase PLPPR1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid phosphate phosphatase-related protein type 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Plasticity-related gene 3 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PLPPR1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in neurite outgrowth and neurogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003911486.2">
        <property type="nucleotide sequence ID" value="XM_003911437.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M943"/>
    <dbReference type="Ensembl" id="ENSPANT00000055269.2">
        <property type="protein sequence ID" value="ENSPANP00000032163.2"/>
        <property type="gene ID" value="ENSPANG00000025678.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008227"/>
    <dbReference type="KEGG" id="panu:101008227"/>
    <dbReference type="CTD" id="54886"/>
    <dbReference type="GeneTree" id="ENSGT00940000158875"/>
    <dbReference type="OMA" id="CRAHHEF"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025678">
        <property type="expression patterns" value="Expressed in Ammon's horn and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000005">
        <property type="entry name" value="phospholipid phosphatase-related protein type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF41">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="16">
        <location>
            <begin position="128"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032163.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="325" mass="35798" checksum="21FD487C2306EA8A" modified="2022-05-25" version="2">MAVGSNTQRSYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVHIQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAQEKTILTGECCYLNPLLRRIIRFTGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSTDCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTKSSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M9A2</accession>
    <name>A0A2I3M9A2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LGALS13</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M9A2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000032234"/>
    <dbReference type="Ensembl" id="ENSPANT00000058444.2">
        <property type="protein sequence ID" value="ENSPANP00000032234.2"/>
        <property type="gene ID" value="ENSPANG00000035222.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162909"/>
    <dbReference type="OMA" id="SDIAFCF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035222">
        <property type="expression patterns" value="Expressed in axillary lymph node and 36 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903077">
        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000176">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF120">
        <property type="entry name" value="GALACTOSIDE-BINDING SOLUBLE LECTIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032234.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="138" mass="15939" checksum="D510BF20562944BF" modified="2022-05-25" version="2">MSSLPVPYKLPVSLSVGSCVIIKGTPIDSFINDPQLQVDFYTDMDEDSDIAFHFVHFGNHVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSFVKMMQVSRDVSLTSVCVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MC35</accession>
    <name>A0A2I3MC35_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MC35"/>
    <dbReference type="Ensembl" id="ENSPANT00000057484.2">
        <property type="protein sequence ID" value="ENSPANP00000033317.1"/>
        <property type="gene ID" value="ENSPANG00000029867.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000143807"/>
    <dbReference type="OMA" id="VFICICY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029867">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="92" mass="10329" checksum="54A56E082D1209C4" modified="2018-02-28" version="1">MCIMTISSEGELELVGLMRLRKQLFLRSALCNHRSRELYGSGRGGALTHFVFVNGGRHLFIDAGTRVPLLDAKGLSFTQDVFICICYCLQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGV7</accession>
    <name>A0A2I3MGV7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PDZD11</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A. Interacts with PLEKHA7 (via WW domains) at zonula adherens; this interaction is essential for the interaction between PLEKHA7 and the ADAM10-binding protein TSPAN33. Interacts with SLC5A6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003917887.2">
        <property type="nucleotide sequence ID" value="XM_003917838.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809705.2">
        <property type="nucleotide sequence ID" value="XM_017954216.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MGV7"/>
    <dbReference type="SMR" id="A0A2I3MGV7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000034973"/>
    <dbReference type="Ensembl" id="ENSPANT00000042356.2">
        <property type="protein sequence ID" value="ENSPANP00000034973.2"/>
        <property type="gene ID" value="ENSPANG00000003830.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002246"/>
    <dbReference type="KEGG" id="panu:101002246"/>
    <dbReference type="CTD" id="51248"/>
    <dbReference type="GeneTree" id="ENSGT00940000153222"/>
    <dbReference type="OMA" id="RGGREHN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003830">
        <property type="expression patterns" value="Expressed in pineal body and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MGV7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06752">
        <property type="entry name" value="PDZ_PDZD11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000096">
        <property type="entry name" value="PDZ domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034973.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="140" mass="16131" checksum="601216B821A36DCE" modified="2022-05-25" version="2">MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MNK0</accession>
    <name>A0A2I3MNK0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MNK0"/>
    <dbReference type="Ensembl" id="ENSPANT00000055192.2">
        <property type="protein sequence ID" value="ENSPANP00000037324.1"/>
        <property type="gene ID" value="ENSPANG00000035519.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038181"/>
    <dbReference type="OMA" id="KWYGSAV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035519">
        <property type="expression patterns" value="Expressed in bone marrow and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF3">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="153" mass="16520" checksum="84190B12EF74C668" modified="2018-02-28" version="1">NGGGAAQGRRSRGLGGNSGAGGGSNCGTGSGRSGLLGKWKIDKPVKIDKWDGSAVKNSLDDSGKKEKSICLMAHRKDPTGMDPDDIWQLSSGLKRFDDKYTLKPTFISGRTKQQREAKFTKSIANFFDHSGTLVLDAYEPEISRLHDSFAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MQT0</accession>
    <name>A0A2I3MQT0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alpha-2,8-sialyltransferase 8E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sialyltransferase 8E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sialyltransferase St8Sia V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ST8SIA5</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87791"/>
            <dbReference type="ChEBI" id="CHEBI:87792"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47593"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003914396.1">
        <property type="nucleotide sequence ID" value="XM_003914347.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MQT0"/>
    <dbReference type="SMR" id="A0A2I3MQT0"/>
    <dbReference type="Ensembl" id="ENSPANT00000054003.2">
        <property type="protein sequence ID" value="ENSPANP00000038020.1"/>
        <property type="gene ID" value="ENSPANG00000024947.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000251"/>
    <dbReference type="KEGG" id="panu:101000251"/>
    <dbReference type="CTD" id="29906"/>
    <dbReference type="GeneTree" id="ENSGT01030000234535"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024947">
        <property type="expression patterns" value="Expressed in cerebellum and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MQT0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23990">
        <property type="entry name" value="GT29_ST8SIA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000004">
        <property type="entry name" value="alpha-2,8-sialyltransferase 8E isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF4">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE 8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="164"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="376" mass="43894" checksum="D15BEAB5C502BC4A" modified="2018-02-28" version="1">MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUZ9</accession>
    <name>A0A2I3MUZ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">JNK-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MAPKBP1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Can form homodimers (via C-terminus). Interacts (via C-terminus) with WDR62 (via C-terminus). Interacts with MAPK9. Interacts (via N-terminus) with NOD2; the interaction is enhanced in presence of muramyl dipeptide (MDP). Interacts with MAPK10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003900862.1">
        <property type="nucleotide sequence ID" value="XM_003900813.5"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000039547"/>
    <dbReference type="Ensembl" id="ENSPANT00000052249.2">
        <property type="protein sequence ID" value="ENSPANP00000039547.1"/>
        <property type="gene ID" value="ENSPANG00000018745.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998968"/>
    <dbReference type="KEGG" id="panu:100998968"/>
    <dbReference type="CTD" id="23005"/>
    <dbReference type="GeneTree" id="ENSGT00940000160664"/>
    <dbReference type="OMA" id="TTTVAYC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018745">
        <property type="expression patterns" value="Expressed in esophagus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MUZ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900425">
        <property type="term" value="P:negative regulation of defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032717">
        <property type="term" value="P:negative regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000091">
        <property type="entry name" value="mitogen-activated protein kinase-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000314">
        <property type="entry name" value="mitogen-activated protein kinase-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000046">
        <property type="entry name" value="WD repeat-containing protein 62 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000124">
        <property type="entry name" value="WD repeat-containing protein 62 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056161">
        <property type="entry name" value="WD40_MABP1-WDR62_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056162">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056364">
        <property type="entry name" value="WDR62-MABP1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24780">
        <property type="entry name" value="WD40_MABP1-WDR62_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24782">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24795">
        <property type="entry name" value="WDR62-MABP1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MABP1/WDR62 first WD40" evidence="15">
        <location>
            <begin position="53"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MABP1/WDR62 second WD40" evidence="16">
        <location>
            <begin position="392"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="MABP1/WRD62 coiled-coil" evidence="17">
        <location>
            <begin position="1413"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="748"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="878"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="945"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1186"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1299"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1113"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1188"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1245"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1514" mass="163582" checksum="9AC4877AC3486284" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MXP2</accession>
    <name>A0A2I3MXP2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein 713</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896005.2">
        <property type="nucleotide sequence ID" value="XM_003895956.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009201180.2">
        <property type="nucleotide sequence ID" value="XM_009202916.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MXP2"/>
    <dbReference type="Ensembl" id="ENSPANT00000038577.2">
        <property type="protein sequence ID" value="ENSPANP00000040534.2"/>
        <property type="gene ID" value="ENSPANG00000009983.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997420"/>
    <dbReference type="KEGG" id="panu:100997420"/>
    <dbReference type="CTD" id="349075"/>
    <dbReference type="GeneTree" id="ENSGT00940000153104"/>
    <dbReference type="OMA" id="YQLEFNQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009983">
        <property type="expression patterns" value="Expressed in olfactory bulb and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MXP2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001914">
        <property type="entry name" value="Zinc finger protein 713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000330">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040534.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="50298" checksum="D98819E38F110152" modified="2022-05-25" version="2">MEEKEMNDGSQMVRSQESLTFQDVAVDFTKEEWDQLYPAQKNLYRDVMLENYRNLVALGYQLYKPEVIAQLELEEEWVIERDSLLDTHPDGENRPEIKKSTTSQNISNENQTHEMIMERLSGDCFWYSILGGLWDFDYHPEFNQENHKRYLGQVTLTHRKITQERSLECNKFAENCNLNSNLMHQRIPSIKIPLNSDTQGNSIKHNSDLVYYQRNYVRETPYEYSECGKIFNQHILLTDHIHTTEKPSECGKAVSHNSSFTQPQMVLTGEKPYKCDECGKRFSQRIHLIQHQRIHTGEKPFICNGCGKAFRQHSSFTQHLRIHTGEKPYKCNQCGKAFSRITSLTEHHRLHTGEKPYECGFCGKAFSQRTHLNQHERTHTGEKPYKCNECGKAFSQSAHLNQHRKIHTREKLCEYKCEQTVCHSPSLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MZ20</accession>
    <name>A0A2I3MZ20_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of the DCX(DCAF13) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF13 and RBX1. Interacts (via WD40 domain) with DDB1. Interacts with ESR1 and LATS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MZ20"/>
    <dbReference type="STRING" id="9555.ENSPANP00000040967"/>
    <dbReference type="Ensembl" id="ENSPANT00000029276.3">
        <property type="protein sequence ID" value="ENSPANP00000040967.2"/>
        <property type="gene ID" value="ENSPANG00000026479.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005711"/>
    <dbReference type="OMA" id="NCIRICT"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026479">
        <property type="expression patterns" value="Expressed in metanephros cortex and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046697">
        <property type="term" value="P:decidualization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000269">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="16">
        <location>
            <begin position="329"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040967.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="420" mass="48163" checksum="2016FF7DF2CFDD4B" modified="2022-05-25" version="2">MSAKPSWTYREVPREYVRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPKNLATVLSGACNGEVRIWNLTQRNCIRTIQAHEGFVQGICTRFCGNSFFTVGDDKTVKQWKMDGPGYGEEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPVETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEVFIFTAANEDYNLYTFDMCALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSQSREVYHTKRMQHVICVKWTSNSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYLHIKHIARHRHLPKSIYSQIQEQCIMKEACQRKEVNRIKHSKPGSVPIVSEKKKHIVAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N4A1</accession>
    <name>A0A2I3N4A1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein interacting with cyclin A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PROCA1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003912573.1">
        <property type="nucleotide sequence ID" value="XM_003912524.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N4A1"/>
    <dbReference type="Ensembl" id="ENSPANT00000046803.2">
        <property type="protein sequence ID" value="ENSPANP00000042842.1"/>
        <property type="gene ID" value="ENSPANG00000023434.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002785"/>
    <dbReference type="CTD" id="147011"/>
    <dbReference type="GeneTree" id="ENSGT00940000162235"/>
    <dbReference type="OMA" id="IHPFSDC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023434">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04705">
        <property type="entry name" value="PLA2_group_III_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000010">
        <property type="entry name" value="Protein interacting with cyclin A1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="337" mass="37851" checksum="013AC6401A546CC0" modified="2018-02-28" version="1">MWVRTTLTIERWTKEKTEPKVRSWDESRCCGDCKEPDKCCWKHKQCTGHIIYPFASDCVCHSLHLRSVNHCNCNSRLKDCSEDSSSSRGTGPTCSHVIESPCFELTPEEQHVERFWYGWCKSYRPVSVAVIHHPLHHECGADDLNEEEEEEEQESKPPIPTQVGPATASPDLGTTMATGTPDSAAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDASRSLSPRQLARMSESSPESREELESEDSYNGRGQEELSSEDILESSSPRKRENTVQAKKTGAKPLQARKVNKRKSPPGSNPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N5G8</accession>
    <name>A0A2I3N5G8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">POLR1B</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the RNA polymerase I (Pol I) complex consisting of 13 subunits: a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3N5G8"/>
    <dbReference type="Ensembl" id="ENSPANT00000041039.2">
        <property type="protein sequence ID" value="ENSPANP00000043263.2"/>
        <property type="gene ID" value="ENSPANG00000023423.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183132"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023423">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N5G8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0071667">
        <property type="term" value="F:DNA/RNA hybrid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1110.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_Rpa2_4"/>
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        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="22">
        <location>
            <begin position="60"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="131"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="399"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="24">
        <location>
            <begin position="507"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="19">
        <location>
            <begin position="614"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="977"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043263.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121992" checksum="E468C25B3F888F9F" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N5S9</accession>
    <name>A0A2I3N5S9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Conserved oligomeric Golgi complex subunit 8</fullName>
            <shortName evidence="9">COG complex subunit 8</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COG8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N5S9"/>
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        <property type="protein sequence ID" value="ENSPANP00000043385.2"/>
        <property type="gene ID" value="ENSPANG00000018697.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015893"/>
    <dbReference type="OMA" id="QRCIHGV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018697">
        <property type="expression patterns" value="Expressed in thymus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N5S9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016632">
        <property type="entry name" value="COG8_Metazoal_Plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015415">
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        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043385.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="545" mass="61683" checksum="E7AD30A1A37B3ACF" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NDD6</accession>
    <name>A0A2I3NDD6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretoglobin family 3A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SCGB3A1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NDD6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000045995"/>
    <dbReference type="Ensembl" id="ENSPANT00000049020.2">
        <property type="protein sequence ID" value="ENSPANP00000045995.2"/>
        <property type="gene ID" value="ENSPANG00000032680.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029848"/>
    <dbReference type="OMA" id="MELTATF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032680">
        <property type="expression patterns" value="Expressed in thymus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901741">
        <property type="term" value="P:positive regulation of myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040301">
        <property type="entry name" value="Secretoglobin_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34829:SF1">
        <property type="entry name" value="SECRETOGLOBIN FAMILY 3A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34829">
        <property type="entry name" value="SECRETOGLOBIN FAMILY 3A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20490">
        <property type="entry name" value="SCGB3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199440" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045995.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="102" mass="10080" checksum="F53E25E7A1706B1F" modified="2022-05-25" version="2">MKLAAALLGLCVALSCGSAAALFVGSAKHVAQPVTELESGAEAAAGTLANPLGTLNLLKLLLASLGIPVNHLVEGSQKCVAELGPEAMGALKTLLGVLTMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NHV5</accession>
    <name>A0A2I3NHV5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Modulator of apoptosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MOAP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017816976.1">
        <property type="nucleotide sequence ID" value="XM_017961487.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NHV5"/>
    <dbReference type="SMR" id="A0A2I3NHV5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000047421"/>
    <dbReference type="Ensembl" id="ENSPANT00000036264.2">
        <property type="protein sequence ID" value="ENSPANP00000047421.1"/>
        <property type="gene ID" value="ENSPANG00000032422.2"/>
    </dbReference>
    <dbReference type="GeneID" id="108586967"/>
    <dbReference type="KEGG" id="panu:108586967"/>
    <dbReference type="CTD" id="64112"/>
    <dbReference type="GeneTree" id="ENSGT01030000234522"/>
    <dbReference type="OMA" id="HAFRRTE"/>
    <dbReference type="OrthoDB" id="115435at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032422">
        <property type="expression patterns" value="Expressed in visual cortex and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051204">
        <property type="term" value="P:protein insertion into mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048271">
        <property type="entry name" value="PNMA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF14">
        <property type="entry name" value="MODULATOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20846">
        <property type="entry name" value="PNMA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paraneoplastic antigen Ma-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Paraneoplastic antigen Ma-like C-terminal" evidence="1">
        <location>
            <begin position="168"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="351" mass="39624" checksum="C7530E4496A6FFB3" modified="2018-02-28" version="1">MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDSDNTFLSRLNEFLAGEGMTVGELTRALAHENGSLDLEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGREPPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQEVLEGHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MW66</accession>
    <name>A0A8I5MW66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-binding protein inhibitor ID-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inhibitor of DNA binding 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Inhibitor of differentiation 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ID2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with GATA4 and NKX2-5. Interacts with NR0B2. Interacts with CLOCK and BMAL1. Interacts with IFI204. Interacts with NEDD9/HEF1. Interacts with ASB4; this interaction promotes ID2 proteasomal degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009181911.1">
        <property type="nucleotide sequence ID" value="XM_009183647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MW66"/>
    <dbReference type="Ensembl" id="ENSPANT00000079544.1">
        <property type="protein sequence ID" value="ENSPANP00000049353.1"/>
        <property type="gene ID" value="ENSPANG00000039736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101017423"/>
    <dbReference type="KEGG" id="panu:101017423"/>
    <dbReference type="CTD" id="3398"/>
    <dbReference type="GeneTree" id="ENSGT00940000156464"/>
    <dbReference type="OMA" id="FPTELMT"/>
    <dbReference type="OrthoDB" id="10047910at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
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    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
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    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
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    <dbReference type="GO" id="GO:0048708">
        <property type="term" value="P:astrocyte differentiation"/>
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    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
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    <dbReference type="GO" id="GO:0003166">
        <property type="term" value="P:bundle of His development"/>
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        <property type="term" value="P:cell maturation"/>
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    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
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    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
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    <dbReference type="GO" id="GO:0090398">
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    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
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    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
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    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
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    <dbReference type="GO" id="GO:0061031">
        <property type="term" value="P:endodermal digestive tract morphogenesis"/>
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    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
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    <dbReference type="GO" id="GO:0043353">
        <property type="term" value="P:enucleate erythrocyte differentiation"/>
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    <dbReference type="GO" id="GO:0061030">
        <property type="term" value="P:epithelial cell differentiation involved in mammary gland alveolus development"/>
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    <dbReference type="GO" id="GO:0033598">
        <property type="term" value="P:mammary gland epithelial cell proliferation"/>
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    <dbReference type="GO" id="GO:0003149">
        <property type="term" value="P:membranous septum morphogenesis"/>
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    <dbReference type="GO" id="GO:0001656">
        <property type="term" value="P:metanephros development"/>
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    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
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    <dbReference type="GO" id="GO:0045578">
        <property type="term" value="P:negative regulation of B cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904339">
        <property type="term" value="P:negative regulation of dopaminergic neuron differentiation"/>
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    <dbReference type="GO" id="GO:0010629">
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    <dbReference type="GO" id="GO:0051148">
        <property type="term" value="P:negative regulation of muscle cell differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0048715">
        <property type="term" value="P:negative regulation of oligodendrocyte differentiation"/>
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    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0021772">
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    <dbReference type="GO" id="GO:0014003">
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    <dbReference type="GO" id="GO:0048541">
        <property type="term" value="P:Peyer's patch development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048711">
        <property type="term" value="P:positive regulation of astrocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045777">
        <property type="term" value="P:positive regulation of blood pressure"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045648">
        <property type="term" value="P:positive regulation of erythrocyte differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010628">
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    <dbReference type="GO" id="GO:0045651">
        <property type="term" value="P:positive regulation of macrophage differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048661">
        <property type="term" value="P:positive regulation of smooth muscle cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001966">
        <property type="term" value="P:thigmotaxis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050872">
        <property type="term" value="P:white fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19692">
        <property type="entry name" value="bHLH_dnHLH_ID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000055">
        <property type="entry name" value="DNA-binding protein inhibitor ID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF5">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR ID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="16">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="203" mass="21487" checksum="986A9B84F8A67A62" modified="2022-05-25" version="1">MDVLPSTNGDEGKPERVAPASADKSRPAGLGLHSEPSPVPSAASSAGGGGGLSFRAASSLPVSSSLAVSMKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N499</accession>
    <name>A0A8I5N499_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcineurin like EF-hand protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CHP2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003916731.1">
        <property type="nucleotide sequence ID" value="XM_003916682.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N499"/>
    <dbReference type="SMR" id="A0A8I5N499"/>
    <dbReference type="Ensembl" id="ENSPANT00000073101.1">
        <property type="protein sequence ID" value="ENSPANP00000051543.1"/>
        <property type="gene ID" value="ENSPANG00000043637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101009526"/>
    <dbReference type="KEGG" id="panu:101009526"/>
    <dbReference type="CTD" id="63928"/>
    <dbReference type="GeneTree" id="ENSGT00940000161957"/>
    <dbReference type="OMA" id="MMVGIQV"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070884">
        <property type="term" value="P:regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042306">
        <property type="term" value="P:regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000093">
        <property type="entry name" value="Calcineurin B homologous protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="196" mass="22438" checksum="36B79EF38AFF2549" modified="2022-05-25" version="1">MGSRSSHAAVIPDADSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFPDGSQQVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7H2</accession>
    <name>A0A8I5N7H2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
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                <person name="Morales K.M."/>
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                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
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                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7H2"/>
    <dbReference type="Ensembl" id="ENSPANT00000062680.1">
        <property type="protein sequence ID" value="ENSPANP00000052198.1"/>
        <property type="gene ID" value="ENSPANG00000037388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
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        <property type="match status" value="1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="129" mass="14779" checksum="B3C8A1DDD2E20B65" modified="2022-05-25" version="1">ILRVIQQPPFFFFFCGDRSFTITQTSLPEHSVSRVVFVCLFFVFIFETESCSIAQAGVQWCYLGSLQPSPPRFKPFSCLSLPSSWDYRRPPPRPASFLYFLVEMGFHHVSQDGLDLRPSRPPKVLGLQA</sequence>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8E0"/>
    <dbReference type="Ensembl" id="ENSPANT00000082161.1">
        <property type="protein sequence ID" value="ENSPANP00000055973.1"/>
        <property type="gene ID" value="ENSPANG00000041812.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    <sequence length="124" mass="14140" checksum="8CA21145B91815C0" modified="2022-05-25" version="1">MVVGACNPSNWGGRKLLGPRRQSLGDRARLRLKKKKKFCLKLLNFFLTWHIYFERKVLCFFLRQSLALSPRLECSGRISAHCKLRLPGSRRSPASVSRVAGTTDARHCARLVFCIFSRDGVSPY</sequence>
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    <accession>A0A8I5NAM3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Bandaranaike D.B."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Dao M.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
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                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
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                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="171" mass="19243" checksum="73E5FD6327631FFD" modified="2022-05-25" version="1">MNHSRNLRMEKIKRQQGHSGGITEVSFQYPDPKRWMVKVTGTKSHCVAQAGVQWCNLSSLQLPPPGFEQFSFLRLPSSWDYRYTPPCLVNFCIFSGDGVSPCWPGWSPTPDLKCFAHLGLPKCTFYFLTLKNHSWLRAILRGHHHSLISIAGTAELNNNCSAGVRGTIHDS</sequence>
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            <fullName evidence="12">Cytochrome c oxidase subunit VIIa-heart</fullName>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity. Despite being highly expressed in brown adipose tissue, not required for thermogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915439.1">
        <property type="nucleotide sequence ID" value="XM_003915390.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031515451.1">
        <property type="nucleotide sequence ID" value="XM_031659591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031515459.1">
        <property type="nucleotide sequence ID" value="XM_031659599.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8I5NAX9"/>
    <dbReference type="Ensembl" id="ENSPANT00000073822.1">
        <property type="protein sequence ID" value="ENSPANP00000058420.1"/>
        <property type="gene ID" value="ENSPANG00000046904.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000075027.1">
        <property type="protein sequence ID" value="ENSPANP00000058808.1"/>
        <property type="gene ID" value="ENSPANG00000042978.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000080835.1">
        <property type="protein sequence ID" value="ENSPANP00000052506.1"/>
        <property type="gene ID" value="ENSPANG00000042139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101021606"/>
    <dbReference type="GeneID" id="116271663"/>
    <dbReference type="GeneID" id="116271667"/>
    <dbReference type="KEGG" id="panu:101021606"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00928">
        <property type="entry name" value="Cyt_c_Oxidase_VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.91.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7A1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003177">
        <property type="entry name" value="Cytc_oxidase_su7a_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510:SF5">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="79" mass="8983" checksum="70EB0BC5A85282AD" modified="2022-05-25" version="1">MQALRVSPALIRSFSSTARNRLQNRVPEKQKLFQEDNDIPLYLKGGFVDNILYRVTMALSLGGSVYSLYCLGWASFPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFM1</accession>
    <name>A0A8I5NFM1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NFM1"/>
    <dbReference type="Ensembl" id="ENSPANT00000073019.1">
        <property type="protein sequence ID" value="ENSPANP00000056303.1"/>
        <property type="gene ID" value="ENSPANG00000038357.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="OMA" id="CPACLFV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035311540" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9242" checksum="FF15EFCC958639D1" modified="2022-05-25" version="1">HFFFFFFFFLRLSLALSPRLECSGQISAHCKLRLPGLRHSPASASGVAGTTGARHLARLVFLYFLVETGFHRVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGG6</accession>
    <name>A0A8I5NGG6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-C motif chemokine 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Small-inducible cytokine A22</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGG6"/>
    <dbReference type="Ensembl" id="ENSPANT00000071196.1">
        <property type="protein sequence ID" value="ENSPANP00000058012.1"/>
        <property type="gene ID" value="ENSPANG00000048992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167783"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00272">
        <property type="entry name" value="Chemokine_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000025">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF102">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="11">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="154" mass="17198" checksum="524467AB9823EBE1" modified="2022-05-25" version="1">MLSCSESLFLELTVPDCRHQTVSGFSEAPRVGSWRAQNPLVTILPHENRKTASLSWSLDRPRSGAGAEGDLSGLQLVHSLGTPPLGPYGANMEDSVCCRDYVRYRMPLRVVKHFYWTSDSCPRPGVVLLTSRDKEICADPRVPWVKMILNKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NIK9</accession>
    <name>A0A8I5NIK9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIK9"/>
    <dbReference type="Ensembl" id="ENSPANT00000077939.1">
        <property type="protein sequence ID" value="ENSPANP00000052779.1"/>
        <property type="gene ID" value="ENSPANG00000044183.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="118" mass="12929" checksum="9897B9BA9BC24C7A" modified="2022-05-25" version="1">MESCSVVRLEGSGAISAHCNFHLPGSRHSPASASQVAGITGVHHHTQLIFVFSVEMGFHHVGQSCVELLVEFRRFAYQVICLPQPPKVLGLQVRATAPGQFFHSLNGIFLKRKLLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJQ3</accession>
    <name>A0A8I5NJQ3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taxilin beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TXLNB</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898152.1">
        <property type="nucleotide sequence ID" value="XM_003898103.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJQ3"/>
    <dbReference type="Ensembl" id="ENSPANT00000075352.1">
        <property type="protein sequence ID" value="ENSPANP00000059969.1"/>
        <property type="gene ID" value="ENSPANG00000041207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101022431"/>
    <dbReference type="KEGG" id="panu:101022431"/>
    <dbReference type="CTD" id="167838"/>
    <dbReference type="GeneTree" id="ENSGT00940000157418"/>
    <dbReference type="OMA" id="SPKMEAN"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF10">
        <property type="entry name" value="BETA-TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="171"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="687" mass="76996" checksum="E038E901A89AEA82" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJW8</accession>
    <name>A0A8I5NJW8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJW8"/>
    <dbReference type="Ensembl" id="ENSPANT00000062744.1">
        <property type="protein sequence ID" value="ENSPANP00000061190.1"/>
        <property type="gene ID" value="ENSPANG00000048201.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000068156.1">
        <property type="protein sequence ID" value="ENSPANP00000055870.1"/>
        <property type="gene ID" value="ENSPANG00000048201.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000072482.1">
        <property type="protein sequence ID" value="ENSPANP00000059618.1"/>
        <property type="gene ID" value="ENSPANG00000048201.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000077241.1">
        <property type="protein sequence ID" value="ENSPANP00000060010.1"/>
        <property type="gene ID" value="ENSPANG00000048201.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000077739.1">
        <property type="protein sequence ID" value="ENSPANP00000058767.1"/>
        <property type="gene ID" value="ENSPANG00000048201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064285"/>
    <dbReference type="OMA" id="WREPNCA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01327">
        <property type="entry name" value="KAZAL_PSTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000031">
        <property type="entry name" value="Serine protease inhibitor Kazal-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042167">
        <property type="entry name" value="SPINK2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47608:SF1">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47608">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 2, SPINK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="192" mass="20667" checksum="D410BC22428B1F59" modified="2022-05-25" version="1">MSEGEVFPLVSSAGRRGCGATTAPSSISLAPSFPMAPSPVLLPFSFPALPGSPSTLHGSSSRRPSCLRHLPLHFLPLSPRPFFLPSPALPAPLASGAGTRAQGPDARRGRRMALAVLRLALLLLAVTFAGPLFRRFSKYKTPFCARYQLPGCPRDFNPVCGTDMITYPNECTLCMKIRESGQNIKIFRRGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLB9</accession>
    <name>A0A8I5NLB9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease A family member 11 (inactive)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RNASE11</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLB9"/>
    <dbReference type="Ensembl" id="ENSPANT00000066763.1">
        <property type="protein sequence ID" value="ENSPANP00000050759.1"/>
        <property type="gene ID" value="ENSPANG00000018895.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000049471"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF22">
        <property type="entry name" value="RIBONUCLEASE 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035295097" evidence="4">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="5">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="250" mass="28357" checksum="187FA03768B17FCF" modified="2022-05-25" version="1">MIIMVIIFLVLLFWENEVNDEVVTSTLEHLHVDYPQNDVPVPARRDYTTSEMETFPLLLLSLGLVLAEASESTMKIIKEEFTEEEMQYDMAKSGQGKQTIEILMNSILLVKNTSLSMSKDDMSSSLLTFRRLHYNDPKGNSSGNDKECCNDMTVWRKVSEANRSCKWSNNFIHDSTEVMHGVHKAPSCKFVQNPGISCRESPELENTVCQLTADKQLPRCQYHSVTSLEKILTVLTGHSLMSWLVCGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLD7</accession>
    <name>A0A8I5NLD7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor A, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer; binds DNA as a monomer. Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLD7"/>
    <dbReference type="Ensembl" id="ENSPANT00000077967.1">
        <property type="protein sequence ID" value="ENSPANP00000060907.1"/>
        <property type="gene ID" value="ENSPANG00000046255.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039001"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21987">
        <property type="entry name" value="HMG-box_TFAM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000043">
        <property type="entry name" value="Transcription factor A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF36">
        <property type="entry name" value="TRANSCRIPTION FACTOR A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="267" mass="30991" checksum="03A769610E77AC7C" modified="2022-05-25" version="1">MITNTGGSHAGSSCDCWGFSVVSGGSPILGPGHCLIRWSDGVSPEHVGRAECAGKVRSGAVQRLWESTALPLQFCVFTEVVFICLGKLSKETYAKTTELVRRIAKHWRELPDSEKKVYREAYKADWEVYKEEISRFKEQLTPSEITSLEKEILDKRLKRKAVTKRKELIQLGKPKRPRSAYNIYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKEIYIQLAKEDEIRYHNEMKSWEEHMIEIGRKDLLRRTIKQRQKYGAEEYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNI3</accession>
    <name>A0A8I5NNI3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Engulfment and cell motility 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELMO1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009201363.1">
        <property type="nucleotide sequence ID" value="XM_009203099.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNI3"/>
    <dbReference type="Ensembl" id="ENSPANT00000078584.1">
        <property type="protein sequence ID" value="ENSPANP00000051937.1"/>
        <property type="gene ID" value="ENSPANG00000022520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006842"/>
    <dbReference type="CTD" id="9844"/>
    <dbReference type="GeneTree" id="ENSGT00940000155994"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="9514336at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13359">
        <property type="entry name" value="PH_ELMO1_CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000049">
        <property type="entry name" value="Engulfment and cell motility 1 (Ced-12 homolog)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000053">
        <property type="entry name" value="Engulfment and cell motility protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF23">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="10">
        <location>
            <begin position="334"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="742" mass="85498" checksum="232A66BE6D71CCDD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNX8</accession>
    <name>A0A8I5NNX8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNX8"/>
    <dbReference type="Ensembl" id="ENSPANT00000081400.1">
        <property type="protein sequence ID" value="ENSPANP00000052165.1"/>
        <property type="gene ID" value="ENSPANG00000007974.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000044430"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="304" mass="32297" checksum="55EAD9A43761CD17" modified="2022-05-25" version="1">MAKPAAAPGGRVSGSPGCHPLPQLLLPSAHPDSRFADWRTTGGVRKAAGLGASVAGDLEHNVRAHQLGMDQLGTTPPCNHAAGTRPLRPLHCLPHAPPGAGFPGVEEGRRPPTLPNSPTSPPPPPPPPHPAASASAQPQSVRRQLCRAQTGSGWGGPQVLNPVPGEPERTLEQEEKEKLVSEASPPPGAMQSLSPEQTRGLLEPERTKTLLPRESRAWEKPPHPTCAKDWEAVEVGASSHDCDEKDLSSQETGLSQEWSSVEEDDESEGSQVHWGVCSFSTNVPLCRSQQFITFAFSAWNLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NPQ9</accession>
    <name>A0A8I5NPQ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NPQ9"/>
    <dbReference type="Ensembl" id="ENSPANT00000062025.1">
        <property type="protein sequence ID" value="ENSPANP00000051027.1"/>
        <property type="gene ID" value="ENSPANG00000044190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006293"/>
    <dbReference type="OMA" id="KFQTVSY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF3">
        <property type="entry name" value="HEAT SHOCK FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="76" mass="8488" checksum="BEF3878184358ED2" modified="2022-05-25" version="1">MAKTDPKTVQDLTLVVQTLLQQMQDKFQTTSDHIIGRIDDMSGRIDDLEKNIADLMTQAGVEELEGENKIPATQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NRD0</accession>
    <name>A0A8I5NRD0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NRD0"/>
    <dbReference type="Ensembl" id="ENSPANT00000066106.1">
        <property type="protein sequence ID" value="ENSPANP00000058006.1"/>
        <property type="gene ID" value="ENSPANG00000040924.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000076598.1">
        <property type="protein sequence ID" value="ENSPANP00000052049.1"/>
        <property type="gene ID" value="ENSPANG00000046256.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157755"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF43">
        <property type="entry name" value="LA-RELATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="572"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="639" mass="69793" checksum="60547BF636D4A7DF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUP2</accession>
    <name>A0A8I5NUP2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUP2"/>
    <dbReference type="Ensembl" id="ENSPANT00000075965.1">
        <property type="protein sequence ID" value="ENSPANP00000059440.1"/>
        <property type="gene ID" value="ENSPANG00000051403.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="HENQVNS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="15">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="14">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="16">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="39569" checksum="19ADCFF7B477F522" modified="2022-05-25" version="1">MGKKQGRKAGNSKNKSTSPPAKERSSSPATDQSWTENDFDEMREEGFSPSNFSELKEELRTQRKETKNLEKKVEELTARVINAEKVINEMKEMKTMTREIRDKCTSFSNRLDQLEERVSAIEDQMNEMKREEKPKEKRRKRNQQSLQEVWDYGKRPNLRLIGVPESEGENGTKLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSSRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTADLSAESLQARREWGPIFNILKEKNFKPRISYPAKLSFISEGEIKSFTDKQMLRDFVTTRPALQETLKEALNMERNNRYQTLQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P3W3</accession>
    <name>A0A8I5P3W3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain containing 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SH3D21</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P3W3"/>
    <dbReference type="Ensembl" id="ENSPANT00000071968.1">
        <property type="protein sequence ID" value="ENSPANP00000060621.1"/>
        <property type="gene ID" value="ENSPANG00000019295.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160627"/>
    <dbReference type="OMA" id="KGPRVNK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11874">
        <property type="entry name" value="SH3_CD2AP-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12142">
        <property type="entry name" value="SH3_D21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035468">
        <property type="entry name" value="SH3D21_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF28">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="710"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="849" mass="92871" checksum="EDA10D08F96146F7" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R004</accession>
    <name>A0A8I5R004_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GJB3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891600.1">
        <property type="nucleotide sequence ID" value="XM_003891551.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R004"/>
    <dbReference type="Ensembl" id="ENSPANT00000027318.3">
        <property type="protein sequence ID" value="ENSPANP00000050794.1"/>
        <property type="gene ID" value="ENSPANG00000021575.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023433"/>
    <dbReference type="KEGG" id="panu:101023433"/>
    <dbReference type="CTD" id="2707"/>
    <dbReference type="GeneTree" id="ENSGT01030000234513"/>
    <dbReference type="OMA" id="HFFPISN"/>
    <dbReference type="OrthoDB" id="9441654at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001890">
        <property type="term" value="P:placenta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002269">
        <property type="entry name" value="Connexin31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF65">
        <property type="entry name" value="GAP JUNCTION BETA-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01140">
        <property type="entry name" value="CONNEXINB3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="12">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="13">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="270" mass="30971" checksum="1425643291B50645" modified="2022-05-25" version="1">MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCTKLYDNTGKKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGASAICIVLTICELCYLICHRVLQGLHKDKPRGGHGRSSSTSRASTCRCHHKLVEAGELDPDPGNNKLQASAPNLTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R0C9</accession>
    <name>A0A8I5R0C9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Epithelial membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EMP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003906084.2">
        <property type="nucleotide sequence ID" value="XM_003906035.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R0C9"/>
    <dbReference type="Ensembl" id="ENSPANT00000072730.1">
        <property type="protein sequence ID" value="ENSPANP00000052236.1"/>
        <property type="gene ID" value="ENSPANG00000044983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101008056"/>
    <dbReference type="KEGG" id="panu:101008056"/>
    <dbReference type="CTD" id="2012"/>
    <dbReference type="GeneTree" id="ENSGT00950000182696"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000026">
        <property type="entry name" value="Epithelial membrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003932">
        <property type="entry name" value="EMP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004032">
        <property type="entry name" value="PMP22_EMP_MP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF6">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01453">
        <property type="entry name" value="EPMEMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01454">
        <property type="entry name" value="EPMEMPROT1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01222">
        <property type="entry name" value="PMP22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="161" mass="17976" checksum="69B1C3ED6C0C96E5" modified="2022-05-25" version="1">MLVLLAGIFVVHIATVIMLFVCTIANVWVVSNAGNASVGLWNNCTNTLCNETLSYANQDALKTVQAFMILSIIFSAISLLVFVFQLFTMEKGNRFFLSGATMLVCWLCVLVGVSIYTNRYANGFGTNYGSEYHHGYSYILAWICFCFSFIIGVLYLVLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2B3</accession>
    <name>A0A8I5R2B3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R2B3"/>
    <dbReference type="Ensembl" id="ENSPANT00000079340.1">
        <property type="protein sequence ID" value="ENSPANP00000058934.1"/>
        <property type="gene ID" value="ENSPANG00000042473.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="256" mass="27645" checksum="3B75577621D7930D" modified="2022-05-25" version="1">MIGAHHLSSWLITRKDGSTQGPQQLWSPGPQIRHPAAPRGTQKAWERVPGRVHMTPHGDMLSHVHSHTAMNNALHSQTHCPASLPSALVDLTATGVQTMNCLTSLQFVLLLLLLLLFLRQSLTLLPRLEGSGIISAPCNLRLLGSSDSPASASQVAGTTGACHHAWLIFVFLVERGFHRVGQAGLELLTSSDPSASASQNVGITGMNHRTRPVRVLLAASSPVPRNLEKMLSGTRWMHRQPQGPSQPSYPSRPPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2B8</accession>
    <name>A0A8I5R2B8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R2B8"/>
    <dbReference type="Ensembl" id="ENSPANT00000063956.1">
        <property type="protein sequence ID" value="ENSPANP00000058994.1"/>
        <property type="gene ID" value="ENSPANG00000037181.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035224396" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="132" mass="14477" checksum="36E840A9B99C380C" modified="2022-05-25" version="1">MTSPLTTATFLSLSFFFETGSCSVTQAGVQWCHLCLLQPQPPGLRQSFCLSLLSSWDHRHPPPHQLICVFLVETGFRHVCQAGLKLLTSGDPPASASQSAAYRHEPPSLASLNIFNPKLFESMDAEPMDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R516</accession>
    <name>A0A8I5R516_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">E3 ubiquitin-protein ligase TRIM21</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="34">52 kDa Ro protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">52 kDa ribonucleoprotein autoantigen Ro/SS-A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">RING-type E3 ubiquitin transferase TRIM5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="37">Ro(SS-A)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="36">Sjoegren syndrome type A antigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">TRIM5alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Tripartite motif-containing protein 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tripartite motif-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="43" type="primary">TRIM21</name>
    </gene>
    <organism evidence="43 44">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="43 44" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="43" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="43" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5R516"/>
    <dbReference type="Ensembl" id="ENSPANT00000074399.1">
        <property type="protein sequence ID" value="ENSPANP00000048196.1"/>
        <property type="gene ID" value="ENSPANG00000046114.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161515"/>
    <dbReference type="OMA" id="CRNSVQR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090086">
        <property type="term" value="P:negative regulation of protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032897">
        <property type="term" value="P:negative regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044790">
        <property type="term" value="P:suppression of viral release by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19772">
        <property type="entry name" value="Bbox2_TRIM21_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16596">
        <property type="entry name" value="RING-HC_TRIM21_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12900">
        <property type="entry name" value="SPRY_PRY_TRIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000386">
        <property type="entry name" value="Tripartite motif-containing 5 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000144">
        <property type="entry name" value="Tripartite motif-containing 5 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035831">
        <property type="entry name" value="PRY/SPRY_TRIM21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020457">
        <property type="entry name" value="Znf_B-box_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01406">
        <property type="entry name" value="BBOXZNFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0007">Acetylation</keyword>
    <keyword evidence="24" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="22" id="KW-0072">Autophagy</keyword>
    <keyword evidence="28" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23 39" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="29" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="25" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="19" id="KW-0391">Immunity</keyword>
    <keyword evidence="12" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="27" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="15 38" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="40">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="41">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="42">
        <location>
            <begin position="268"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="39">
        <location>
            <begin position="132"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00004201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008518"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00014825"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00032496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00033283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00072866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00076800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00077845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00078316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00081331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00083069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="474" mass="54194" checksum="451510B0E8C1036A" modified="2022-05-25" version="1">MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKDGGSVCPVCRQHFLLRNLRPNRQLANMVDNLREISQEAREGAQEEQCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAMKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAELAQQSQALQELISELERRRQGSALELLQEVIIVLERSESWNLKGLDIASPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQIGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGRNTAPLTLCPLNIGQGSTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R604</accession>
    <name>A0A8I5R604_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TYMS</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003914259.1">
        <property type="nucleotide sequence ID" value="XM_003914210.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R604"/>
    <dbReference type="SMR" id="A0A8I5R604"/>
    <dbReference type="Ensembl" id="ENSPANT00000066585.1">
        <property type="protein sequence ID" value="ENSPANP00000050825.1"/>
        <property type="gene ID" value="ENSPANG00000016982.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022652"/>
    <dbReference type="KEGG" id="panu:101022652"/>
    <dbReference type="CTD" id="7298"/>
    <dbReference type="GeneTree" id="ENSGT00390000014786"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000008">
        <property type="entry name" value="thymidylate synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="313" mass="35633" checksum="114561E5E9ACBFCD" modified="2022-05-25" version="1">MPVAGSELPRPPLQPASQERDAEPRPPHGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSAREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R7E3</accession>
    <name>A0A8I5R7E3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nesprin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">KASH domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nuclear envelope spectrin repeat protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SYNE3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus outer membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021797225.2">
        <property type="nucleotide sequence ID" value="XM_021941533.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021797227.2">
        <property type="nucleotide sequence ID" value="XM_021941535.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031523731.1">
        <property type="nucleotide sequence ID" value="XM_031667871.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031523732.1">
        <property type="nucleotide sequence ID" value="XM_031667872.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031523733.1">
        <property type="nucleotide sequence ID" value="XM_031667873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R7E3"/>
    <dbReference type="Ensembl" id="ENSPANT00000077173.1">
        <property type="protein sequence ID" value="ENSPANP00000053708.1"/>
        <property type="gene ID" value="ENSPANG00000023982.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016938"/>
    <dbReference type="CTD" id="161176"/>
    <dbReference type="GeneTree" id="ENSGT00440000039367"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000237">
        <property type="entry name" value="Spectrin repeat containing nuclear envelope family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000247">
        <property type="entry name" value="Spectrin repeat-containing, nuclear envelope family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000364">
        <property type="entry name" value="Spectrin repeat-containing, nuclear envelope family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057932">
        <property type="entry name" value="Spectrin_SYNE1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057933">
        <property type="entry name" value="SYNE3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF2">
        <property type="entry name" value="NESPRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25803">
        <property type="entry name" value="Spectrin_SYNE1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25804">
        <property type="entry name" value="SYNE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="15">
        <location>
            <begin position="1"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="15">
        <location>
            <begin position="947"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="18">
        <location>
            <begin position="917"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="975" mass="111923" checksum="2FC040D583C05D45" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J8XUR8</accession>
    <name>A0A8J8XUR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STK32C</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8J8XUR8"/>
    <dbReference type="SMR" id="A0A8J8XUR8"/>
    <dbReference type="Ensembl" id="ENSPANT00000027226.4">
        <property type="protein sequence ID" value="ENSPANP00000016130.3"/>
        <property type="gene ID" value="ENSPANG00000020132.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160573"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000169">
        <property type="entry name" value="Serine/threonine-protein kinase 32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000160">
        <property type="entry name" value="Serine/threonine-protein kinase 32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF32">
        <property type="entry name" value="SERINE_THREONINE KINASE 32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016130.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="368" mass="42299" checksum="200D30EECEF7DB95" modified="2022-05-25" version="1">MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLCGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSLGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSREMVALLRKLLTVNPEHRFSSLQDVQAAPALAGVLWGHLSEKRVEPDFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNREKLKRSQDLPSEPLPAPEPRDAAEPVEDEEHSALPMCGPICPSAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKR2</accession>
    <name>A0A096MKR2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">THO complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">THOC7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009198667.2">
        <property type="nucleotide sequence ID" value="XM_009200403.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKR2"/>
    <dbReference type="SMR" id="A0A096MKR2"/>
    <dbReference type="Ensembl" id="ENSPANT00000017094.3">
        <property type="protein sequence ID" value="ENSPANP00000000088.3"/>
        <property type="gene ID" value="ENSPANG00000009531.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997407"/>
    <dbReference type="KEGG" id="panu:100997407"/>
    <dbReference type="CTD" id="80145"/>
    <dbReference type="eggNOG" id="KOG3215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002873"/>
    <dbReference type="HOGENOM" id="CLU_1668849_0_0_1"/>
    <dbReference type="OMA" id="WANSKND"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009531">
        <property type="expression patterns" value="Expressed in putamen and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MKR2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000088.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="204" mass="23729" checksum="CB0D2608A37B5BFC" modified="2022-05-25" version="3">MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEDAQEASMETDPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ML96</accession>
    <name>A0A096ML96_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 186 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM186B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003906388.2">
        <property type="nucleotide sequence ID" value="XM_003906339.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096ML96"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000308"/>
    <dbReference type="Ensembl" id="ENSPANT00000009428.3">
        <property type="protein sequence ID" value="ENSPANP00000000308.3"/>
        <property type="gene ID" value="ENSPANG00000005455.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026474"/>
    <dbReference type="KEGG" id="panu:101026474"/>
    <dbReference type="CTD" id="84070"/>
    <dbReference type="eggNOG" id="ENOG502S05D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162031"/>
    <dbReference type="HOGENOM" id="CLU_015516_0_0_1"/>
    <dbReference type="OMA" id="TMTVHSR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005455">
        <property type="expression patterns" value="Expressed in testis and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096ML96">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049146">
        <property type="entry name" value="FAM186A_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049144">
        <property type="entry name" value="FAM186A_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33590">
        <property type="entry name" value="GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33590:SF3">
        <property type="entry name" value="PROTEIN FAM186B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20865">
        <property type="entry name" value="FAM186A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20870">
        <property type="entry name" value="FAM186A-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM186A/B N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FAM186A/B C-terminal" evidence="2">
        <location>
            <begin position="660"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000308.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="894" mass="103505" checksum="9B0FB8FE3786A60F" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMA5</accession>
    <name>A0A096MMA5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="19">6.2.1.15</ecNumber>
            <ecNumber evidence="19">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Acyl-CoA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACSL1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 19">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="19"/>
    <dbReference type="EC" id="6.2.1.3" evidence="19"/>
    <dbReference type="RefSeq" id="XP_003899458.2">
        <property type="nucleotide sequence ID" value="XM_003899409.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003899460.2">
        <property type="nucleotide sequence ID" value="XM_003899411.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MMA5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000728"/>
    <dbReference type="Ensembl" id="ENSPANT00000015189.3">
        <property type="protein sequence ID" value="ENSPANP00000000728.3"/>
        <property type="gene ID" value="ENSPANG00000013760.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025016"/>
    <dbReference type="KEGG" id="panu:101025016"/>
    <dbReference type="CTD" id="2180"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154508"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013760">
        <property type="expression patterns" value="Expressed in subcutaneous adipose tissue and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MMA5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000006">
        <property type="entry name" value="long-chain-fatty-acid--CoA ligase 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF28">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 19" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="116"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000728.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="698" mass="77878" checksum="9051BD8E4604636D" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPS6</accession>
    <name>A0A096MPS6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TIMM10</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909904.1">
        <property type="nucleotide sequence ID" value="XM_003909855.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003909905.1">
        <property type="nucleotide sequence ID" value="XM_003909856.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017803864.1">
        <property type="nucleotide sequence ID" value="XM_017948375.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MPS6"/>
    <dbReference type="SMR" id="A0A096MPS6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001743"/>
    <dbReference type="Ensembl" id="ENSPANT00000019804.3">
        <property type="protein sequence ID" value="ENSPANP00000001743.1"/>
        <property type="gene ID" value="ENSPANG00000000871.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021440"/>
    <dbReference type="KEGG" id="panu:101021440"/>
    <dbReference type="CTD" id="26519"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003068"/>
    <dbReference type="HOGENOM" id="CLU_162151_2_0_1"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000871">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="90" mass="10333" checksum="D20EFAE694D14BAB" modified="2014-11-26" version="1">MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTI9</accession>
    <name>A0A096MTI9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TATDN1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003903193.1">
        <property type="nucleotide sequence ID" value="XM_003903144.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTI9"/>
    <dbReference type="Ensembl" id="ENSPANT00000009340.3">
        <property type="protein sequence ID" value="ENSPANP00000003123.1"/>
        <property type="gene ID" value="ENSPANG00000001330.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021516"/>
    <dbReference type="KEGG" id="panu:101021516"/>
    <dbReference type="CTD" id="83940"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156272"/>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001330">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTI9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000034">
        <property type="entry name" value="putative deoxyribonuclease TATDN1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="297" mass="33691" checksum="C4620F51623C0E20" modified="2014-11-26" version="1">MGRFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNDMFFSTVGCHPTRCDEFEKSNPDLYLKELLNLAENNKEKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIKTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTZ8</accession>
    <name>A0A096MTZ8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARSB</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017815173.2">
        <property type="nucleotide sequence ID" value="XM_017959684.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTZ8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003291"/>
    <dbReference type="Ensembl" id="ENSPANT00000017931.4">
        <property type="protein sequence ID" value="ENSPANP00000003291.2"/>
        <property type="gene ID" value="ENSPANG00000023320.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101021373"/>
    <dbReference type="KEGG" id="panu:101021373"/>
    <dbReference type="CTD" id="411"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158270"/>
    <dbReference type="OMA" id="HEHCVFI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023320">
        <property type="expression patterns" value="Expressed in iris and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTZ8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003943">
        <property type="term" value="F:N-acetylgalactosamine-4-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061580">
        <property type="term" value="P:colon epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010632">
        <property type="term" value="P:regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000002">
        <property type="entry name" value="Arylsulfatase family member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035277610" evidence="7">
        <location>
            <begin position="41"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003291.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="535" mass="59930" checksum="B56E568297A1DCEC" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWF1</accession>
    <name>A0A096MWF1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009182135.1">
        <property type="nucleotide sequence ID" value="XM_009183871.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWF1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004207"/>
    <dbReference type="Ensembl" id="ENSPANT00000026360.3">
        <property type="protein sequence ID" value="ENSPANP00000004207.2"/>
        <property type="gene ID" value="ENSPANG00000000675.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999514"/>
    <dbReference type="CTD" id="285126"/>
    <dbReference type="eggNOG" id="KOG0716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000148505"/>
    <dbReference type="HOGENOM" id="CLU_017633_14_1_1"/>
    <dbReference type="OMA" id="FIMNSCW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000675">
        <property type="expression patterns" value="Expressed in heart and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
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    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004207.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="173" mass="19564" checksum="356FBB1533905B52" modified="2022-05-25" version="2">MSTVNEAAHRLSKSGTSLYAVLELKKGASPEDVKKSYRKLALQYHPDKNPGNTQAAEIFKEINAAHAILSDPKKRKIYDQHGSLGIYLYDHFGEEGVRYYFILNSCWFKTLVILCTLLTCCCFCCCCCFCCGTLKPPPEQDSGRKYQQNVQSQPPRSGAKGDFRREENSEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXK8</accession>
    <name>A0A096MXK8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myosin light chain 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MYL5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MXK8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004626"/>
    <dbReference type="Ensembl" id="ENSPANT00000009625.3">
        <property type="protein sequence ID" value="ENSPANP00000004626.3"/>
        <property type="gene ID" value="ENSPANG00000011909.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163023"/>
    <dbReference type="HOGENOM" id="CLU_061288_9_3_1"/>
    <dbReference type="OMA" id="EVNQMFQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011909">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 34 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MXK8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004626.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="172" mass="19347" checksum="00F8C7A11F60B0E4" modified="2022-05-25" version="3">MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYASLGKTNVKDDELDAMLKEASGPINFTMFLNMFGEKLSGTDAEETILNAFKMLDPDGKGKINKEYIKRLLMSQADKMTADEVDQMFQFASIDAAGNLDKALSYVITHGEEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0P8</accession>
    <name>A0A096N0P8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Contactin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CNTN3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with PTPRG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. Contactin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009198597.3">
        <property type="nucleotide sequence ID" value="XM_009200333.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810776.2">
        <property type="nucleotide sequence ID" value="XM_017955287.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810777.2">
        <property type="nucleotide sequence ID" value="XM_017955288.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810778.2">
        <property type="nucleotide sequence ID" value="XM_017955289.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0P8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005836"/>
    <dbReference type="Ensembl" id="ENSPANT00000025210.3">
        <property type="protein sequence ID" value="ENSPANP00000005836.2"/>
        <property type="gene ID" value="ENSPANG00000011424.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000089"/>
    <dbReference type="KEGG" id="panu:101000089"/>
    <dbReference type="CTD" id="5067"/>
    <dbReference type="eggNOG" id="KOG3513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160282"/>
    <dbReference type="HOGENOM" id="CLU_005756_0_0_1"/>
    <dbReference type="OMA" id="HKLMGAR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011424">
        <property type="expression patterns" value="Expressed in aorta and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000044">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000047">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000052">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000054">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000064">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF18">
        <property type="entry name" value="CONTACTIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146775" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="227"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="318"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="408"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="499"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="600"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="703"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="805"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="902"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005836.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112770" checksum="4726F213929A99AB" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N215</accession>
    <name>A0A096N215_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase family 16C member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SDR16C5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017817518.1">
        <property type="nucleotide sequence ID" value="XM_017962029.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N215"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006356"/>
    <dbReference type="Ensembl" id="ENSPANT00000013905.3">
        <property type="protein sequence ID" value="ENSPANP00000006356.1"/>
        <property type="gene ID" value="ENSPANG00000005056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998417"/>
    <dbReference type="CTD" id="195814"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156731"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_5_1"/>
    <dbReference type="OMA" id="RTPMIKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005056">
        <property type="expression patterns" value="Expressed in zone of skin and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N215">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000202">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 16C member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF728">
        <property type="entry name" value="EPIDERMAL RETINOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="309" mass="34410" checksum="9E88357186C6C0C3" modified="2014-11-26" version="1">MSFNLQSSKKLFIFLGKSLFTLLEAMIFALLPKQQKNVAGEIVLITGSGSGLGRLLALQFARRGSVLVLWDVNKEGNEETCKMAQEAGVTRVHAYTCDCSQKEEVYRVADQVKKEVGDVSILINNAGIVTGKNFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLVGVNGLADYCASKFAAFGLAESVFVETFVQNQKGIKTTIVCPFFIKTGMFEGCTTACPSLLPILEPEYAAEKIVEAILQEKMYFYMPKFLYFMMFLKSFLPLKTVLLIGDYLDIFHAMDGFLERKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5Z9</accession>
    <name>A0A096N5Z9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ras-related protein Rab-13</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RAB13</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with BICDL2/BICDR2. Interacts with LEPROT and LEPROTL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle membrane</location>
            <topology evidence="14">Lipid-anchor</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003892746.1">
        <property type="nucleotide sequence ID" value="XM_003892697.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N5Z9"/>
    <dbReference type="SMR" id="A0A096N5Z9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007882"/>
    <dbReference type="Ensembl" id="ENSPANT00000024531.3">
        <property type="protein sequence ID" value="ENSPANP00000007882.2"/>
        <property type="gene ID" value="ENSPANG00000004479.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017542"/>
    <dbReference type="KEGG" id="panu:101017542"/>
    <dbReference type="CTD" id="5872"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159989"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="OMA" id="CLIVRFS"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004479">
        <property type="expression patterns" value="Expressed in aorta and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N5Z9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035767">
        <property type="term" value="P:endothelial cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902463">
        <property type="term" value="P:protein localization to cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007882.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="203" mass="22774" checksum="141621CB998178DA" modified="2018-02-28" version="2">MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N6X3</accession>
    <name>A0A096N6X3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIGZ</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A096N6X3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008254"/>
    <dbReference type="Ensembl" id="ENSPANT00000018665.3">
        <property type="protein sequence ID" value="ENSPANP00000008254.2"/>
        <property type="gene ID" value="ENSPANG00000004650.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163773"/>
    <dbReference type="HOGENOM" id="CLU_022957_1_1_1"/>
    <dbReference type="OMA" id="HGIHPRY"/>
    <dbReference type="Proteomes" id="UP000028761">
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N700</accession>
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        <submittedName>
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        <name evidence="3" type="primary">CARD6</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
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                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
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        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 6"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009181995.1">
        <property type="nucleotide sequence ID" value="XM_009183731.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009181998.1">
        <property type="nucleotide sequence ID" value="XM_009183734.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009181999.1">
        <property type="nucleotide sequence ID" value="XM_009183735.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009182002.1">
        <property type="nucleotide sequence ID" value="XM_009183738.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031509821.1">
        <property type="nucleotide sequence ID" value="XM_031653961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NAL4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009744"/>
    <dbReference type="Ensembl" id="ENSPANT00000018209.3">
        <property type="protein sequence ID" value="ENSPANP00000009744.1"/>
        <property type="gene ID" value="ENSPANG00000019805.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011356"/>
    <dbReference type="KEGG" id="panu:101011356"/>
    <dbReference type="CTD" id="81875"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159724"/>
    <dbReference type="HOGENOM" id="CLU_022453_0_0_1"/>
    <dbReference type="OMA" id="PCPIVDY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019805">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06149">
        <property type="entry name" value="ISG20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037433">
        <property type="entry name" value="ISG20_DEDDh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF78">
        <property type="entry name" value="INTERFERON-STIMULATED 20 KDA EXONUCLEASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="179"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="354" mass="39393" checksum="1FD0A6CACB3C055E" modified="2014-11-26" version="1">MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPPKKGETPMVDGTWKTPSFPKKKKTAACSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLGEFQSALPKISSHPTRSQKKGSQKKSSKKNHPQKNAPQNSTQAHSENKCSRISQKLPQKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENATMSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELYKLVEVEWEEHLAQNPPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAN2</accession>
    <name>A0A096NAN2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SWI/SNF related BAF chromatin remodeling complex subunit C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SMARCC2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021778191.2">
        <property type="nucleotide sequence ID" value="XM_021922499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NAN2"/>
    <dbReference type="Ensembl" id="ENSPANT00000006598.3">
        <property type="protein sequence ID" value="ENSPANP00000009767.3"/>
        <property type="gene ID" value="ENSPANG00000021074.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001681"/>
    <dbReference type="KEGG" id="panu:101001681"/>
    <dbReference type="CTD" id="6601"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155746"/>
    <dbReference type="HOGENOM" id="CLU_004447_0_1_1"/>
    <dbReference type="OMA" id="KGGTIMD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021074">
        <property type="expression patterns" value="Expressed in mammillary body and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NAN2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021877">
        <property type="term" value="P:forebrain neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
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    <keyword evidence="2 7" id="KW-0156">Chromatin regulator</keyword>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="424"/>
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            <begin position="627"/>
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            <begin position="632"/>
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            <begin position="1"/>
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            <begin position="978"/>
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            <begin position="1028"/>
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            <begin position="1213"/>
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        <location>
            <begin position="275"/>
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            <begin position="331"/>
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            <begin position="379"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS52032"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="1245" mass="136224" checksum="5E9565E44C6AAD31" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NBI7</accession>
    <name>A0A096NBI7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase small subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein ADMP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Small subunit of serine palmitoyltransferase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SPTSSB</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity. SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SPTSS family. SPTSSB subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_017955736.2"/>
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    <dbReference type="RefSeq" id="XP_017811226.1">
        <property type="nucleotide sequence ID" value="XM_017955737.2"/>
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        <property type="protein sequence ID" value="ENSPANP00000010135.1"/>
        <property type="gene ID" value="ENSPANG00000017115.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Bgee" id="ENSPANG00000017115">
        <property type="expression patterns" value="Expressed in urinary bladder and 54 other cell types or tissues"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
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    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum organization"/>
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        <property type="term" value="P:sphingosine biosynthetic process"/>
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        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
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        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B"/>
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        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B"/>
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        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="76" mass="9198" checksum="F43280DBC07B5A0E" modified="2014-11-26" version="1">MDLRRVKEYFSWLYYQYQIISCCAVLEPWERSMFNTILLTIIAMVVYTAYVFIPIHIRLAWEFFSKICGYHSTISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NE46</accession>
    <name>A0A096NE46_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain 34B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANKRD34B</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009206953.1">
        <property type="nucleotide sequence ID" value="XM_009208689.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021795198.1">
        <property type="nucleotide sequence ID" value="XM_021939506.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021795199.1">
        <property type="nucleotide sequence ID" value="XM_021939507.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021795200.1">
        <property type="nucleotide sequence ID" value="XM_021939508.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021795201.1">
        <property type="nucleotide sequence ID" value="XM_021939509.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522142.1">
        <property type="nucleotide sequence ID" value="XM_031666282.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522144.1">
        <property type="nucleotide sequence ID" value="XM_031666284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NE46"/>
    <dbReference type="SMR" id="A0A096NE46"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011154"/>
    <dbReference type="Ensembl" id="ENSPANT00000004353.3">
        <property type="protein sequence ID" value="ENSPANP00000011154.1"/>
        <property type="gene ID" value="ENSPANG00000021025.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000267"/>
    <dbReference type="KEGG" id="panu:101000267"/>
    <dbReference type="CTD" id="340120"/>
    <dbReference type="eggNOG" id="ENOG502QRZ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012355"/>
    <dbReference type="HOGENOM" id="CLU_042805_0_0_1"/>
    <dbReference type="OMA" id="AFPLDHN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021025">
        <property type="expression patterns" value="Expressed in putamen and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF1">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="514" mass="56456" checksum="33A517FEC5B2BB6D" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEI7</accession>
    <name>A0A096NEI7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L26 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL26L1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NEI7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011307"/>
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        <property type="protein sequence ID" value="ENSPANP00000011307.3"/>
        <property type="gene ID" value="ENSPANG00000012204.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000014165"/>
    <dbReference type="HOGENOM" id="CLU_093240_0_0_1"/>
    <dbReference type="OMA" id="WIIHVER"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="Bgee" id="ENSPANG00000012204">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KOW"/>
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        <property type="entry name" value="Rib_uL2_dom2"/>
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        <property type="entry name" value="Ribosomal_uL24_CS"/>
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        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
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        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
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    <dbReference type="Pfam" id="PF00467">
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        <property type="entry name" value="Translation proteins SH3-like domain"/>
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        <property type="entry name" value="RIBOSOMAL_L24"/>
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        <location>
            <begin position="48"/>
            <end position="76"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011307.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="145" mass="17270" checksum="090D5BA0239E9F36" modified="2022-05-25" version="3">MKFNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTIHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEELIEKMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFC2</accession>
    <name>A0A096NFC2_PAPAN</name>
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        <submittedName>
            <fullName evidence="4">DENN domain containing 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DENND2A</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000018260.4"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182931"/>
    <dbReference type="HOGENOM" id="CLU_008960_1_1_1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Bgee" id="ENSPANG00000018260">
        <property type="expression patterns" value="Expressed in mammillary body and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NFC2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="DENN domain-containing protein 2A isoform X1"/>
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        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03455">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02141">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03456">
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00799">
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50211">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="497"/>
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            <begin position="45"/>
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            <begin position="502"/>
            <end position="512"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011615.3"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113509" checksum="3C41F5F1025D6CF2" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFD5</accession>
    <name>A0A096NFD5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichyl-phosphate beta-glucosyltransferase</fullName>
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        <alternativeName>
            <fullName evidence="14">Asparagine-linked glycosylation protein 5 homolog</fullName>
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    </protein>
    <gene>
        <name evidence="17" type="primary">ALG5</name>
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    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003913824.1">
        <property type="nucleotide sequence ID" value="XM_003913775.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NFD5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011631"/>
    <dbReference type="Ensembl" id="ENSPANT00000018959.3">
        <property type="protein sequence ID" value="ENSPANP00000011631.1"/>
        <property type="gene ID" value="ENSPANG00000005232.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006511"/>
    <dbReference type="KEGG" id="panu:101006511"/>
    <dbReference type="CTD" id="29880"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153481"/>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="OMA" id="HMVNTDA"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005232">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NFD5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098556">
        <property type="term" value="C:cytoplasmic side of rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000068">
        <property type="entry name" value="ALG5, dolichyl-phosphate beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922722" description="Dolichyl-phosphate beta-glucosyltransferase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="16">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="324" mass="36932" checksum="8990BA3507F905A0" modified="2014-11-26" version="1">MALLLLQLAVLGAALAAAALVLISVVAFITATKMPALHRHEEEKFFLNAKGQKETLPSIWDLPTKQLSVVVPSYNEEKRLPVMMDEALSYLEKRQKRDPAFTYEVIVVDDGSKDKTSKVAFKYCQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASQTFSSLHVERWAFDVELLYIAQCFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIRLRYMTGAWRLEQTRKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGD9</accession>
    <name>A0A096NGD9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cadherin EGF LAG seven-pass G-type receptor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Multiple epidermal growth factor-like domains protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">CELSR3</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Receptor that may have an important role in cell/cell signaling during nervous system formation.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
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    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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            <end position="2775"/>
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    </feature>
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            <begin position="213"/>
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            <begin position="2361"/>
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            <begin position="3084"/>
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    </feature>
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        <location>
            <begin position="159"/>
            <end position="173"/>
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    </feature>
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        <location>
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            <end position="225"/>
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    </feature>
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        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="2380"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="2890"/>
            <end position="2900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="2919"/>
            <end position="2928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="3174"/>
            <end position="3198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="3246"/>
            <end position="3281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="3287"/>
            <end position="3300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="1748"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="2010"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="2077"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="2079"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="2098"/>
            <end position="2107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00071751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012013.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="3312" mass="358654" checksum="FA5DB0C1D199214C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NJ39</accession>
    <name>A0A096NJ39_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCR4-NOT transcription complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCR4-associated factor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct. Interacts with YTHDF2; the interaction is direct and promotes recruitment of the CCR4-NOT complex to N6-methyladenosine (m6A)-containing mRNAs, leading to their deadenylation and subsequent degradation. Interacts with EIF4ENIF1/4E-T. Interacts in an RNA-independent manner with BICC1 (via KH domains). Interacts with TEX13A; the interaction may inhibit CNOT1 binding to mRNA and subsequently CNOT1-mediated mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CNOT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031514042.1">
        <property type="nucleotide sequence ID" value="XM_031658182.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000016845.3">
        <property type="protein sequence ID" value="ENSPANP00000012988.3"/>
        <property type="gene ID" value="ENSPANG00000020901.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020568"/>
    <dbReference type="CTD" id="23019"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014869"/>
    <dbReference type="HOGENOM" id="CLU_000286_3_0_1"/>
    <dbReference type="OMA" id="HMDHEVR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020901">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NJ39">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000005">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23590">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
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        <location>
            <begin position="167"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="17">
        <location>
            <begin position="440"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="16">
        <location>
            <begin position="739"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="19">
        <location>
            <begin position="962"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="15">
        <location>
            <begin position="1350"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032531"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23590"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012988.3"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1728" mass="194439" checksum="ED505850253C4A33" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NKW9</accession>
    <name>A0A096NKW9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein S34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MRPS34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000020905.3"/>
    </dbReference>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020905">
        <property type="expression patterns" value="Expressed in amygdala and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mS34"/>
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    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="196"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="218" mass="25644" checksum="B924FDBFDED38691" modified="2022-05-25" version="3">MARKKVRPRLIAELARRVRALREKLNRPRDSQLYAVDYETLTRPFSGRRLPVRAWADVRRESRLFQLLGRLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVQPDYTAQNLDHGKAWGILTFKGKTESEAREIEHVMYHDWRLVPKHEEEAFTAFTPAPEDSLASVPYPPLLRAMILAERQKNGDTSTEEPMLNVQRTRMEPWDYPAKQEDKGRAKGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLI3</accession>
    <name>A0A096NLI3_PAPAN</name>
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        <name evidence="21" type="primary">ZNF322</name>
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        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with POU5F1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897246.1">
        <property type="nucleotide sequence ID" value="XM_003897197.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202870.1">
        <property type="nucleotide sequence ID" value="XM_009204606.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009202871.1">
        <property type="nucleotide sequence ID" value="XM_009204607.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLI3"/>
    <dbReference type="Ensembl" id="ENSPANT00000020826.3">
        <property type="protein sequence ID" value="ENSPANP00000013841.2"/>
        <property type="gene ID" value="ENSPANG00000016590.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007641"/>
    <dbReference type="KEGG" id="panu:101007641"/>
    <dbReference type="CTD" id="79692"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162956"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_10_1"/>
    <dbReference type="OMA" id="CNVSDKG"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016590">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002988">
        <property type="entry name" value="RCG45242, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002323">
        <property type="entry name" value="Zinc finger protein 322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002339">
        <property type="entry name" value="Zinc finger protein 322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003317">
        <property type="entry name" value="Zinc finger protein 322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001468">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF122">
        <property type="entry name" value="SIMILAR TO ZINC FINGER PROTEIN 84 (HPF2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013841.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="402" mass="46953" checksum="E40C693B9CFC4099" modified="2018-02-28" version="2">MYTSEERCNQRTQKRKIYNVCPQKGKKIFIHVHEITQIDGHIYQCLECKQNFCENLALIMCERTHTGEKPYKCDMCEKTFVQSSDLISHQRIHNYEKPYKCSKCEKSFWHHLALSGHQRTHAGKKFYTCDICGKNFGQSSDLLVHQRSHTGEKPYLCSECDKCFSRSTNLIRHRRTHTGEKPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEKSYRHRSAFIVHKRVHTGEKPYKCGACEKCFGQKSDLIVHQRVHTGEKPYKCLECMRSFTRSANLIRHQATHTHTFKCLEYEKSFNCSSDLIVHQRIHMEEKPHQWSTCESGFLLGMDFVAQQKMRTQTEELHYKYTVCDKSFHQSSALLQHQTVHIGEKPFICNVSEKGLELSPPHASEASQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NM67</accession>
    <name>A0A096NM67_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Testis expressed 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009208502.1">
        <property type="nucleotide sequence ID" value="XM_009210238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NM67"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014076"/>
    <dbReference type="Ensembl" id="ENSPANT00000017664.4">
        <property type="protein sequence ID" value="ENSPANP00000014076.1"/>
        <property type="gene ID" value="ENSPANG00000017298.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000061680.1">
        <property type="protein sequence ID" value="ENSPANP00000052640.1"/>
        <property type="gene ID" value="ENSPANG00000042533.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000062859.1">
        <property type="protein sequence ID" value="ENSPANP00000050902.1"/>
        <property type="gene ID" value="ENSPANG00000040761.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000070987.1">
        <property type="protein sequence ID" value="ENSPANP00000053336.1"/>
        <property type="gene ID" value="ENSPANG00000039390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101017846"/>
    <dbReference type="KEGG" id="panu:101017846"/>
    <dbReference type="GeneTree" id="ENSGT00390000018333"/>
    <dbReference type="HOGENOM" id="CLU_059201_0_0_1"/>
    <dbReference type="OMA" id="QISCEYY"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017298">
        <property type="expression patterns" value="Expressed in metanephros cortex and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NM67">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44748" checksum="964D96B11D2768FB" modified="2014-11-26" version="1">MAGRSLGLTRSSVPGTPLPPPVQQPSTPGPDLLALEEEYKRLNAELQAKTADVVRQAKEIIRDRQEVRSRPVSKQMKSCDDEDDYSLRGVLPSEGIVHLHSETKPKTKNIDPVNKVQNKLHSANKGRKTNSSVKLKYSDVQTADDVAIPEDFSDFSLAKTISKIEGQLEEEGLPEYTDDIFSGVSNDIGTEAQIRFLKAKLRVMQEELDNVVCECNKKEDEIQNLKSQVKKFEEDFMRQQRTINMQQSQVEKYKTLFEEANKKCDGLQQQLSSVERELENKRRLQKQAASSQSATEVRLNRALEEAEKYKLELSKLRQNNKDIANEEHKKIEVLKSENKKLEKQKGELMIGFKKQLKLIDVLKRQKMHIEAAKMLSFTEEEFMKALEWGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NN04</accession>
    <name>A0A096NN04_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 6 superfamily member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TM6SF1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May function as sterol isomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TM6SF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901363.1">
        <property type="nucleotide sequence ID" value="XM_003901314.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NN04"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014364"/>
    <dbReference type="Ensembl" id="ENSPANT00000023014.3">
        <property type="protein sequence ID" value="ENSPANP00000014364.2"/>
        <property type="gene ID" value="ENSPANG00000020642.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101027040"/>
    <dbReference type="KEGG" id="panu:101027040"/>
    <dbReference type="CTD" id="53346"/>
    <dbReference type="eggNOG" id="ENOG502QRB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012913"/>
    <dbReference type="HOGENOM" id="CLU_046717_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020642">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NN04">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21106">
        <property type="entry name" value="TM6SF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047195">
        <property type="entry name" value="TM6SF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059044">
        <property type="entry name" value="TM_Tm6sf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568:SF10">
        <property type="entry name" value="TRANSMEMBRANE 6 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568">
        <property type="entry name" value="TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26083">
        <property type="entry name" value="TM_Tm6sf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014364.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="370" mass="41690" checksum="3331160002587C83" modified="2018-02-28" version="2">MSASAATGVFVLSLSAIPVTYVFNYLAAQHDSWTIVGVAALILFLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGLIALDCPSELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSVPYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKILFLALNIAYGVLPQLLVYRCIYKPEFFIKTKAEEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NPF5</accession>
    <name>A0A096NPF5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Abasic site processing protein HMCES</fullName>
            <shortName evidence="19">ES cell-specific 5hmC-binding protein</shortName>
            <ecNumber evidence="19">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 19">Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 19">Peptidase HMCES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">SRAP domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">HMCES</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then either reversed or degraded. HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites. The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase. Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts (via PIP-box motif) with PCNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_003906932.1">
        <property type="nucleotide sequence ID" value="XM_003906883.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NPF5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014885"/>
    <dbReference type="Ensembl" id="ENSPANT00000005858.3">
        <property type="protein sequence ID" value="ENSPANP00000014885.1"/>
        <property type="gene ID" value="ENSPANG00000012065.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020835"/>
    <dbReference type="KEGG" id="panu:101020835"/>
    <dbReference type="CTD" id="56941"/>
    <dbReference type="eggNOG" id="KOG2618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018439"/>
    <dbReference type="HOGENOM" id="CLU_035990_1_0_1"/>
    <dbReference type="OMA" id="SYNKGPQ"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012065">
        <property type="expression patterns" value="Expressed in putamen and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NPF5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140431">
        <property type="term" value="F:DNA-(abasic site) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160129">
        <property type="term" value="F:protein-DNA covalent cross-linking activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045830">
        <property type="term" value="P:positive regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1680.10:FF:000001">
        <property type="entry name" value="Abasic site processing protein HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 19" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="354" mass="40556" checksum="39DF5044EC06ED71" modified="2014-11-26" version="1">MCGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNNPVLLSRLHFEKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDTIMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKTEKSGSTGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGEEAVSKWLDFGEVSTQEALKLIHSTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELKASGSSQRMLQWLATKSPKKEDSKTPQKEESDVPQWSSQFLQKSSLPTKRGTAGLLEQWLKREKEEEPVAKRPYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQG1</accession>
    <name>A0A096NQG1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Putative protein-lysine deacylase ABHD14B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha/beta hydrolase domain-containing protein 14B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABHD14B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as an atypical protein-lysine deacetylase in vitro. Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues. Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo. Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate. May activate transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:45950"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">May interact with TAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894389.1">
        <property type="nucleotide sequence ID" value="XM_003894340.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQG1"/>
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        <property type="protein sequence ID" value="ENSPANP00000015257.3"/>
        <property type="gene ID" value="ENSPANG00000008142.3"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:acyltransferase activity"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="Abhydrolase domain containing 14B"/>
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        <property type="entry name" value="PROTEIN-LYSINE DEACYLASE ABHD14B-RELATED"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="15">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
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            <begin position="21"/>
            <end position="30"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00038705"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00041074"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043029"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045947"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049262"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12697"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015257.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="275" mass="29124" checksum="4AE0B3E621E0D2C2" modified="2022-05-25" version="3">MDPASLWPQEGAPEHGPVPAPAGWGPASSPTIPPPGPIHRQYASASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREARPSSGQAHFSVLLLHGIRFSSETWQNLGTLHRLAQAGYQAVAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALELGPPVVISPSLSGMYSLPFLTAPGSQLRGYVPVAPICTDKINAANYASVKTPALIVYGDQDPMGQSSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRU5</accession>
    <name>A0A096NRU5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transducer of ERBB2, 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TOB2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905651.1">
        <property type="nucleotide sequence ID" value="XM_003905602.5"/>
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    <dbReference type="SMR" id="A0A096NRU5"/>
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    <dbReference type="Ensembl" id="ENSPANT00000019683.3">
        <property type="protein sequence ID" value="ENSPANP00000015765.1"/>
        <property type="gene ID" value="ENSPANG00000009655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999854"/>
    <dbReference type="KEGG" id="panu:100999854"/>
    <dbReference type="CTD" id="10766"/>
    <dbReference type="eggNOG" id="KOG4006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154208"/>
    <dbReference type="HOGENOM" id="CLU_034687_0_0_1"/>
    <dbReference type="OMA" id="NGGISYM"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009655">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042809">
        <property type="term" value="F:nuclear vitamin D receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045671">
        <property type="term" value="P:negative regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045778">
        <property type="term" value="P:positive regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="FunFam" id="3.90.640.90:FF:000001">
        <property type="entry name" value="TOB1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
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    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
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    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
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    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
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    <dbReference type="InterPro" id="IPR015676">
        <property type="entry name" value="Tob1/2"/>
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    <dbReference type="PANTHER" id="PTHR17537:SF3">
        <property type="entry name" value="PROTEIN TOB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17537">
        <property type="entry name" value="TRANSDUCER OF ERBB2 TOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="4">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="169"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="192"/>
            <end position="225"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="210"/>
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    </feature>
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        <location>
            <begin position="211"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="335" mass="35829" checksum="1C1566DE9FF73898" modified="2014-11-26" version="1">MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKNKYEGHWYPEKPLKGSGFRCVHIGEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGCGAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQSPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTNSLLKHKSLSLSMHSLNFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGAGTCNSSSFDMAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQPFQPVVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRW2</accession>
    <name>A0A096NRW2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Insulin-induced gene protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mediates feedback control of cholesterol synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interaction with SCAP is mutually exclusive with PAQR3. Interacts with HMGCR (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with AMFR/gp78 (via its membrane domain); the interaction recruits HMCR at the ER membrane for its ubiquitination and degradation by the sterol-mediated ERAD pathway. Interacts with SOAT2/ACAT2; leading to promote recruitment of AMFR/gp78 and subsequent ubiquitination of SOAT2/ACAT2. Interacts with RNF139. Interacts with RNF145.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896958.1">
        <property type="nucleotide sequence ID" value="XM_003896909.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NRW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015782"/>
    <dbReference type="Ensembl" id="ENSPANT00000008662.3">
        <property type="protein sequence ID" value="ENSPANP00000015782.1"/>
        <property type="gene ID" value="ENSPANG00000017185.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015556"/>
    <dbReference type="KEGG" id="panu:101015556"/>
    <dbReference type="CTD" id="3638"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00580000081600"/>
    <dbReference type="HOGENOM" id="CLU_092922_0_0_1"/>
    <dbReference type="OMA" id="ENHTWSC"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017185">
        <property type="expression patterns" value="Expressed in liver and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032937">
        <property type="term" value="C:SREBP-SCAP-Insig complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036316">
        <property type="term" value="P:SREBP-SCAP complex retention in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF11">
        <property type="entry name" value="INSULIN-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU241113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="277" mass="29788" checksum="68EFC0C5A9B1E6D7" modified="2014-11-26" version="1">MPRLHDHFWSCSCAHSARRRGPPRASAAGLAAKVGEMISASVSGPSLLAAHGAPDADPAPGGRSAAMSGPEPGGPYPNTWHHRLVQRSLVLFSVGVVLALVLNLLQIQRNVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSI2</accession>
    <name>A0A096NSI2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrator complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">INTS1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="9555.ENSPANP00000016003"/>
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        <property type="protein sequence ID" value="ENSPANP00000016003.2"/>
        <property type="gene ID" value="ENSPANG00000009859.3"/>
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    <dbReference type="eggNOG" id="KOG4596">
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Bgee" id="ENSPANG00000009859">
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    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001833">
        <property type="term" value="P:inner cell mass cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR053964">
        <property type="entry name" value="INT1_R3"/>
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    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
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    <dbReference type="InterPro" id="IPR053966">
        <property type="entry name" value="INTS1_INTS2-bd"/>
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    <dbReference type="InterPro" id="IPR053965">
        <property type="entry name" value="INTS1_R4"/>
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    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22927">
        <property type="entry name" value="INT1_R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22929">
        <property type="entry name" value="INTS1_INTS2-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22928">
        <property type="entry name" value="INTS1_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="2">
        <location>
            <begin position="323"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 INTS2-binding" evidence="5">
        <location>
            <begin position="976"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R3" evidence="3">
        <location>
            <begin position="1841"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R4" evidence="4">
        <location>
            <begin position="2057"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="951"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016003.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2196" mass="244408" checksum="E94AAAC5E0F17B02" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTL5</accession>
    <name>A0A096NTL5_PAPAN</name>
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        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LRRC45</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="8">Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003913594.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NTL5"/>
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    <dbReference type="Ensembl" id="ENSPANT00000010696.3">
        <property type="protein sequence ID" value="ENSPANP00000016386.3"/>
        <property type="gene ID" value="ENSPANG00000019031.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011627"/>
    <dbReference type="KEGG" id="panu:101011627"/>
    <dbReference type="CTD" id="201255"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154003"/>
    <dbReference type="HOGENOM" id="CLU_015877_0_0_1"/>
    <dbReference type="OMA" id="EVDHMTR"/>
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        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Bgee" id="ENSPANG00000019031">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 61 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Leucine-rich repeat-containing protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000459">
        <property type="entry name" value="Leucine-rich repeat-containing protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Centro_Cilium_Assembly"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
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    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="298"/>
            <end position="642"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00058896"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016386.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUW0</accession>
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        <submittedName>
            <fullName evidence="8">BPI fold containing family A member 2</fullName>
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    </protein>
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        <name evidence="8" type="primary">BPIFA2</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. Plunc family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NUW0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016835"/>
    <dbReference type="Ensembl" id="ENSPANT00000003837.3">
        <property type="protein sequence ID" value="ENSPANP00000016835.1"/>
        <property type="gene ID" value="ENSPANG00000024266.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TE6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="HOGENOM" id="CLU_097590_0_0_1"/>
    <dbReference type="OMA" id="CPLIHIF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024266">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052507">
        <property type="entry name" value="BPI_fold-antibacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47145">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47145:SF1">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001929230" evidence="6">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="249" mass="27068" checksum="76567DDD3C9F0ED3" modified="2014-11-26" version="1">MLQLWKLVLLCGVLTGTSESLLDNLGSDLSNVVNELKPILHDGLETVDNTLKGVLEKLKVDLGVLQKSSAWQLAKQKAQEAEKLLNNVVSKLLPTNTNTLGLKISDSLILDVKAEPIDGGKGLNLSFPVTADVTTTLPIIGQIVNLKASLDLLTAVSIETDPQTNQSVAVLGECASDPTSISLSLLDNRSQIINNVVNRVINTLKSTVSFLVQKEICPLIRIFLHSLDVKFIQQIIDNLQHETQLQTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVT1</accession>
    <name>A0A096NVT1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NVT1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017156"/>
    <dbReference type="Ensembl" id="ENSPANT00000013654.3">
        <property type="protein sequence ID" value="ENSPANP00000017156.3"/>
        <property type="gene ID" value="ENSPANG00000000660.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TAJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164098"/>
    <dbReference type="HOGENOM" id="CLU_118168_3_1_1"/>
    <dbReference type="OMA" id="KITQDPM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019730">
        <property type="term" value="P:antimicrobial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000017">
        <property type="entry name" value="CST9 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043250">
        <property type="entry name" value="CST9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46945:SF4">
        <property type="entry name" value="CYSTATIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46945">
        <property type="entry name" value="CYSTATIN-9-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00666">
        <property type="entry name" value="Cathelicidins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035325880" description="Cystatin domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017156.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16773" checksum="6291A62BD40961F6" modified="2022-05-25" version="3">MSNTQRRKALPWALSLLLMGFQLLVTYAQCSEEEMGGNNKITQDPMFLTTVEFALNTFNVQSKEEHAYRLLRVLSSWREDRNWRGKMVFSMNLQLRHTVCWKFEDDIENCPFQESPELNNVRQGVSFPQVHNCGSGKAIPSDKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWA0</accession>
    <name>A0A096NWA0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Killer cell lectin like receptor B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KLRB1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003906006.1">
        <property type="nucleotide sequence ID" value="XM_003905957.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWA0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017327"/>
    <dbReference type="Ensembl" id="ENSPANT00000006115.3">
        <property type="protein sequence ID" value="ENSPANP00000017327.3"/>
        <property type="gene ID" value="ENSPANG00000017447.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001921"/>
    <dbReference type="KEGG" id="panu:101001921"/>
    <dbReference type="CTD" id="3820"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154685"/>
    <dbReference type="HOGENOM" id="CLU_049894_8_2_1"/>
    <dbReference type="OMA" id="TENKWIC"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017447">
        <property type="expression patterns" value="Expressed in spleen and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042269">
        <property type="term" value="P:regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051527">
        <property type="entry name" value="KLR_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46784">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46784:SF1">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="101"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017327.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="227" mass="25483" checksum="8F0D21F4AAB1F9F0" modified="2022-05-25" version="3">MDQQMMYAELTLPKDSGPESSSPSSLPRDVCQGSPWHQVALKLSCAGIILLVLVVTGLSLSVASLLQKPSIGKCSVDIQQNTTKTTERPDLLKCPIYWQQVQEKCLLLSQTVKPWNNSLADCSTKESSLLLIQDKDELTRTQNLIHDKAISFWIGLNFSLSEKNWKWINGSFLSSNDLKITGDAKENSCVYISQTSVYSEYCSTEMKWICQKELTLVRNKVSPDSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NX14</accession>
    <name>A0A096NX14_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CKLF like MARVEL transmembrane domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CMTM5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NX14"/>
    <dbReference type="Ensembl" id="ENSPANT00000006757.3">
        <property type="protein sequence ID" value="ENSPANP00000017604.2"/>
        <property type="gene ID" value="ENSPANG00000022753.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161867"/>
    <dbReference type="HOGENOM" id="CLU_108546_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022753">
        <property type="expression patterns" value="Expressed in lateral globus pallidus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NX14">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF26">
        <property type="entry name" value="CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017604.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="156" mass="17488" checksum="30DC5431BACAF3F4" modified="2018-02-28" version="2">MLSVRDRRDRPPEEGVVAELQGFAVDKTFFTSHKGILLETELALTLIIFICFTASISAYMAAALLEFFITLAFLFLYATQYYQHFNRLNWPCLDFLRCVSAIIIFLVVSFAAVTSRDGAAIAAFVFGIILVSVFAYDAFKIYRTEMAPGAIQGDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXI5</accession>
    <name>A0A096NXI5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 2-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDK2AP1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDK2AP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NXI5"/>
    <dbReference type="Ensembl" id="ENSPANT00000006141.3">
        <property type="protein sequence ID" value="ENSPANP00000017780.1"/>
        <property type="gene ID" value="ENSPANG00000026348.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008431"/>
    <dbReference type="KEGG" id="panu:101008431"/>
    <dbReference type="CTD" id="8099"/>
    <dbReference type="eggNOG" id="KOG4713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155149"/>
    <dbReference type="HOGENOM" id="CLU_130479_1_0_1"/>
    <dbReference type="OMA" id="WMIYCIV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026348">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NXI5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037709">
        <property type="entry name" value="CDK2-associated_p2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="114" mass="12264" checksum="E12A91CB2286E0E9" modified="2014-11-26" version="1">MSYKPNLAAHMPAAALNAAGSVHSPSTSMASSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZ31</accession>
    <name>A0A096NZ31_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Serine/threonine-protein kinase PINK1, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Serine/threonine-protein kinase Pink1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">PINK1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Upon mitochondrial depolarization, it forms a supercomplex with TOM and TIM23 complexes. PINK1-TOM-TIM23 supercomplex formation requires PINK1 interaction with TOMM20 and TOMM70 and is critical for PINK1 stabilization at the outer mitochondrial membrane, kinase activation and downstream mitophagy. Upon mitochondrial depolarization, interacts with TIMM23; the interaction is required for PINK1 accumulation at the outer mitochondrial membrane, kinase activation by autophosphorylation and PRKN recruitement to mitochondria. Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7. Interacts with NENF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003891311.1">
        <property type="nucleotide sequence ID" value="XM_003891262.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZ31"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018349"/>
    <dbReference type="Ensembl" id="ENSPANT00000012641.4">
        <property type="protein sequence ID" value="ENSPANP00000018349.1"/>
        <property type="gene ID" value="ENSPANG00000015168.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101024255"/>
    <dbReference type="KEGG" id="panu:101024255"/>
    <dbReference type="CTD" id="65018"/>
    <dbReference type="eggNOG" id="KOG4158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001206"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015168">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZ31">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097449">
        <property type="term" value="C:astrocyte projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055131">
        <property type="term" value="F:C3HC4-type RING finger domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014046">
        <property type="term" value="P:dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072655">
        <property type="term" value="P:establishment of protein localization to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072656">
        <property type="term" value="P:maintenance of protein location in mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099074">
        <property type="term" value="P:mitochondrion to lysosome vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902902">
        <property type="term" value="P:negative regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903384">
        <property type="term" value="P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903298">
        <property type="term" value="P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090258">
        <property type="term" value="P:negative regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000378">
        <property type="term" value="P:negative regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903852">
        <property type="term" value="P:positive regulation of cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033603">
        <property type="term" value="P:positive regulation of dopamine secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902958">
        <property type="term" value="P:positive regulation of mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032226">
        <property type="term" value="P:positive regulation of synaptic transmission, dopaminergic"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905091">
        <property type="term" value="P:positive regulation of type 2 mitophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010310">
        <property type="term" value="P:regulation of hydrogen peroxide metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903214">
        <property type="term" value="P:regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031396">
        <property type="term" value="P:regulation of protein ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14018">
        <property type="entry name" value="STKc_PINK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000418">
        <property type="entry name" value="PTEN induced kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040110">
        <property type="entry name" value="PINK1_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="156"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00062732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00071830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00074253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="581" mass="63121" checksum="8844915863CA6DB9" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1I6</accession>
    <name>A0A096P1I6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cerberus</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cerberus-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CER1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Forms monomers and predominantly dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003911749.1">
        <property type="nucleotide sequence ID" value="XM_003911700.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P1I6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019211"/>
    <dbReference type="Ensembl" id="ENSPANT00000025772.3">
        <property type="protein sequence ID" value="ENSPANP00000019211.1"/>
        <property type="gene ID" value="ENSPANG00000025225.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012677"/>
    <dbReference type="KEGG" id="panu:101012677"/>
    <dbReference type="CTD" id="9350"/>
    <dbReference type="eggNOG" id="ENOG502S2G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063926"/>
    <dbReference type="HOGENOM" id="CLU_104447_0_0_1"/>
    <dbReference type="OMA" id="KKFWDHF"/>
    <dbReference type="OrthoDB" id="9950584at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025225">
        <property type="expression patterns" value="Expressed in aorta and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016015">
        <property type="term" value="F:morphogen activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042074">
        <property type="term" value="P:cell migration involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048263">
        <property type="term" value="P:determination of dorsal identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003419">
        <property type="term" value="P:growth plate cartilage chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032926">
        <property type="term" value="P:negative regulation of activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000381">
        <property type="term" value="P:negative regulation of mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035582">
        <property type="term" value="P:sequestering of BMP in extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023019">
        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001657">
        <property type="term" value="P:ureteric bud development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000042">
        <property type="entry name" value="Cerberus 1 homolog (Xenopus laevis)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016860">
        <property type="entry name" value="Cerberus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15273:SF4">
        <property type="entry name" value="CERBERUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15273">
        <property type="entry name" value="DAN DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027807">
        <property type="entry name" value="Cerberus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024527485" description="Cerberus" evidence="11">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="14">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR027807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="269" mass="30479" checksum="05AA122B10A67673" modified="2014-11-26" version="1">MHLLLLQLLVLLTLTLGKATRHQDGRQNQNSLSPALLPRNQRELPTSNHEEAEEKPDLFVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMRPSRDSDSEHFPPGNQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKSPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAEQHSHTFCSHCLPAKFTTMHLPLNCTEVSSVIKVVMLVEECQCKVKTEHEDGHFLHAGSQDSFIPGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P202</accession>
    <name>A0A096P202_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP157 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P202"/>
    <dbReference type="Ensembl" id="ENSPANT00000024719.3">
        <property type="protein sequence ID" value="ENSPANP00000019377.2"/>
        <property type="gene ID" value="ENSPANG00000024833.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000070928.1">
        <property type="protein sequence ID" value="ENSPANP00000059877.1"/>
        <property type="gene ID" value="ENSPANG00000037567.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111240"/>
    <dbReference type="HOGENOM" id="CLU_025198_2_0_1"/>
    <dbReference type="OMA" id="ARYQKKC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024833">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P202">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038844">
        <property type="entry name" value="CFAP157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019377.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="521" mass="60277" checksum="6D8D1A70036221A0" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2N5</accession>
    <name>A0A096P2N5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CLDN7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912277.1">
        <property type="nucleotide sequence ID" value="XM_003912228.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009187799.1">
        <property type="nucleotide sequence ID" value="XM_009189535.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2N5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019610"/>
    <dbReference type="Ensembl" id="ENSPANT00000023344.3">
        <property type="protein sequence ID" value="ENSPANP00000019610.1"/>
        <property type="gene ID" value="ENSPANG00000024214.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021217"/>
    <dbReference type="KEGG" id="panu:101021217"/>
    <dbReference type="CTD" id="1366"/>
    <dbReference type="eggNOG" id="ENOG502QPXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160672"/>
    <dbReference type="HOGENOM" id="CLU_076370_1_2_1"/>
    <dbReference type="OMA" id="ACAWCTH"/>
    <dbReference type="OrthoDB" id="10025519at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024214">
        <property type="expression patterns" value="Expressed in ascending colon and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003552">
        <property type="entry name" value="Claudin7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01381">
        <property type="entry name" value="CLAUDIN7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001923249" description="Claudin" evidence="10">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="211" mass="22545" checksum="F1D5B12AB527B013" modified="2014-11-26" version="1">MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALPAAMQATRALMVVSLVLAFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALIACSWYGHQIVTDFYNPLIPTNMKYEFGPAIFIGWAGSALVILGGALLSCSCPRNESKAGYHAPRSYPKSNSSKEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2Z9</accession>
    <name>A0A096P2Z9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 287</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZNF287</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021784447.1">
        <property type="nucleotide sequence ID" value="XM_021928755.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2Z9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019724"/>
    <dbReference type="Ensembl" id="ENSPANT00000022607.3">
        <property type="protein sequence ID" value="ENSPANP00000019724.2"/>
        <property type="gene ID" value="ENSPANG00000023719.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026161"/>
    <dbReference type="KEGG" id="panu:101026161"/>
    <dbReference type="CTD" id="57336"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162333"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_5_1"/>
    <dbReference type="OMA" id="KTEAQEC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023719">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000252">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000479">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001178">
        <property type="entry name" value="zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002029">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="17">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="18">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="396"/>
            <end position="423"/>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Beltran B.B."/>
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                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017799664.1">
        <property type="nucleotide sequence ID" value="XM_017944175.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P612"/>
    <dbReference type="SMR" id="A0A096P612"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020787"/>
    <dbReference type="Ensembl" id="ENSPANT00000014195.3">
        <property type="protein sequence ID" value="ENSPANP00000020787.2"/>
        <property type="gene ID" value="ENSPANG00000021352.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020246"/>
    <dbReference type="KEGG" id="panu:101020246"/>
    <dbReference type="CTD" id="80019"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158630"/>
    <dbReference type="HOGENOM" id="CLU_070348_1_0_1"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021352">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd17120">
        <property type="entry name" value="Ubl_UBTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020787.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="227" mass="25938" checksum="7D34DB6027797255" modified="2018-02-28" version="2">MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWA1</accession>
    <name>A0A0A0MWA1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF57</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWA1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008886"/>
    <dbReference type="Ensembl" id="ENSPANT00000005241.3">
        <property type="protein sequence ID" value="ENSPANP00000008886.3"/>
        <property type="gene ID" value="ENSPANG00000019079.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182755"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_3_1"/>
    <dbReference type="OMA" id="YILEKNW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019079">
        <property type="expression patterns" value="Expressed in esophagus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MWA1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000156">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001587">
        <property type="entry name" value="Zinc finger protein 57"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008886.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="536" mass="62237" checksum="D28598205D1B9F8D" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LE19</accession>
    <name>A0A2I3LE19_PAPAN</name>
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        <recommendedName>
            <fullName evidence="3">Voltage-dependent L-type calcium channel subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Calcium channel voltage-dependent subunit beta 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CACNB1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel beta subunit family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031657056.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A2I3LE19"/>
    <dbReference type="SMR" id="A0A2I3LE19"/>
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        <property type="protein sequence ID" value="ENSPANP00000021682.2"/>
        <property type="gene ID" value="ENSPANG00000021980.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999288"/>
    <dbReference type="CTD" id="782"/>
    <dbReference type="GeneTree" id="ENSGT00950000182837"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021980">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904646">
        <property type="term" value="P:cellular response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902514">
        <property type="term" value="P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CAB1-4_N_A-dom"/>
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        <property type="entry name" value="GK/Ca_channel_bsu"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="VDCC_L_b1su"/>
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    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01627">
        <property type="entry name" value="LCACHANNELB1"/>
    </dbReference>
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        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="8" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="100"/>
            <end position="169"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="18">
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    </feature>
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        <location>
            <begin position="43"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="54"/>
            <end position="71"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="530"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="548"/>
            <end position="559"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019007"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022568"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045982"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021682.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="598" mass="65682" checksum="FF0A7FB04C2098CA" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LLL0</accession>
    <name>A0A2I3LLL0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="21">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ATP2B2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="21"/>
    <dbReference type="RefSeq" id="XP_003894154.1">
        <property type="nucleotide sequence ID" value="XM_003894105.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810742.1">
        <property type="nucleotide sequence ID" value="XM_017955253.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810743.1">
        <property type="nucleotide sequence ID" value="XM_017955254.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017810744.1">
        <property type="nucleotide sequence ID" value="XM_017955255.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LLL0"/>
    <dbReference type="Ensembl" id="ENSPANT00000050305.2">
        <property type="protein sequence ID" value="ENSPANP00000024390.1"/>
        <property type="gene ID" value="ENSPANG00000012883.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021808"/>
    <dbReference type="CTD" id="491"/>
    <dbReference type="GeneTree" id="ENSGT00940000161461"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012883">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LLL0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903779">
        <property type="term" value="P:regulation of cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
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    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
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    <dbReference type="FunFam" id="1.20.1110.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
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    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
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    <dbReference type="FunFam" id="3.40.1110.10:FF:000032">
        <property type="entry name" value="Calcium-transporting ATPase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF377">
        <property type="entry name" value="PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1194"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1196"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1220"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1243" mass="136892" checksum="739582C1E494AEA7" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LM47</accession>
    <name>A0A2I3LM47_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adaptor related protein complex 3 subunit sigma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AP3S1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900062.1">
        <property type="nucleotide sequence ID" value="XM_003900013.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LM47"/>
    <dbReference type="SMR" id="A0A2I3LM47"/>
    <dbReference type="Ensembl" id="ENSPANT00000033374.2">
        <property type="protein sequence ID" value="ENSPANP00000024586.2"/>
        <property type="gene ID" value="ENSPANG00000031545.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100997222"/>
    <dbReference type="KEGG" id="panu:100997222"/>
    <dbReference type="CTD" id="1176"/>
    <dbReference type="GeneTree" id="ENSGT00970000193421"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031545">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024586.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="193" mass="21732" checksum="1EF17F375881288D" modified="2022-05-25" version="2">MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LZ32</accession>
    <name>A0A2I3LZ32_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock 70 kDa protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MSANTD7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LZ32"/>
    <dbReference type="Ensembl" id="ENSPANT00000051806.2">
        <property type="protein sequence ID" value="ENSPANP00000028716.2"/>
        <property type="gene ID" value="ENSPANG00000023296.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163231"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023296">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LZ32">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10238">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000008">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000433">
        <property type="entry name" value="Heat shock protein family A (Hsp70) member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042049">
        <property type="entry name" value="HSPA14_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028716.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="689" mass="75453" checksum="07A01164B198B3AF" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M1P2</accession>
    <name>A0A2I3M1P2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Poly(rC) binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PCBP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M1P2"/>
    <dbReference type="Ensembl" id="ENSPANT00000038089.2">
        <property type="protein sequence ID" value="ENSPANP00000029646.2"/>
        <property type="gene ID" value="ENSPANG00000011314.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161582"/>
    <dbReference type="OMA" id="SHHLIGY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022646">
        <property type="expression patterns" value="Expressed in metanephros cortex and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M1P2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098847">
        <property type="term" value="F:sequence-specific single stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039694">
        <property type="term" value="P:viral RNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22515">
        <property type="entry name" value="KH-I_PCBP1_2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22518">
        <property type="entry name" value="KH-I_PCBP1_2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22521">
        <property type="entry name" value="KH-I_PCBP1_2_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000002">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000003">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000005">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029646.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="339" mass="35612" checksum="9B41D3665BA0F7C1" modified="2022-05-25" version="2">MDAGVTESGLNVTLTIRLLMHGKEVGSIIGKKGESVKRIREESGARINISEGNCPERIITLTGPTNAIFKAFAMIIDKLEEDINSSMTNSTAASRPPVTLRLVVPATQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGVPQSVTECVKQICLVMLETLSQSPQGRVMTIPYQPMPASSPVICAGGQDRCSDAAGYPHATHDLEGPPLDAYSIQGQQSHFAMMHGGTGFAGIDSSSPEVKGYWASLDASTQTTHELTIPNNLIGCIIGRQGANINEIRQMSGAQIKIANPVEGSSGRQVTITGSAASISLAQYLINARLSSEKGMGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M2F5</accession>
    <name>A0A2I3M2F5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione S-transferase</fullName>
            <ecNumber evidence="10">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GSTP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate</text>
            <dbReference type="Rhea" id="RHEA:50260"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:132200"/>
            <dbReference type="ChEBI" id="CHEBI:132201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:50261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50800"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133370"/>
            <dbReference type="ChEBI" id="CHEBI:133769"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:50801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50804"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133396"/>
            <dbReference type="ChEBI" id="CHEBI:133771"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:50805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50808"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133396"/>
            <dbReference type="ChEBI" id="CHEBI:133772"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:50809"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with CDK5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003909509.2">
        <property type="nucleotide sequence ID" value="XM_003909460.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M2F5"/>
    <dbReference type="SMR" id="A0A2I3M2F5"/>
    <dbReference type="Ensembl" id="ENSPANT00000053905.2">
        <property type="protein sequence ID" value="ENSPANP00000029911.2"/>
        <property type="gene ID" value="ENSPANG00000004067.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008213"/>
    <dbReference type="KEGG" id="panu:101008213"/>
    <dbReference type="CTD" id="2950"/>
    <dbReference type="GeneTree" id="ENSGT00940000162460"/>
    <dbReference type="OMA" id="KKSCVFG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004067">
        <property type="expression patterns" value="Expressed in pineal body and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097057">
        <property type="term" value="C:TRAF2-GSTP1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035730">
        <property type="term" value="F:S-nitrosoglutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901687">
        <property type="term" value="P:glutathione derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051122">
        <property type="term" value="P:hepoxilin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110076">
        <property type="term" value="P:negative regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071638">
        <property type="term" value="P:negative regulation of monocyte chemotactic protein-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03210">
        <property type="entry name" value="GST_C_Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03076">
        <property type="entry name" value="GST_N_Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000047">
        <property type="entry name" value="Glutathione S-transferase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000071">
        <property type="entry name" value="Glutathione S-transferase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000392">
        <property type="entry name" value="Glutathione S-transferase pi 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003082">
        <property type="entry name" value="GST_pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF255">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01268">
        <property type="entry name" value="GSTRNSFRASEP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="12">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029911.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="210" mass="23438" checksum="4DE128B6A6C45434" modified="2022-05-25" version="2">MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTMETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTFLRHLGRTLGLYGKDQREAALVDMVNDGVEDLRCKYLSLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVARLSARPKLKAFLASPEHVNLPINGNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M2J2</accession>
    <name>A0A2I3M2J2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pro-neuregulin-3, membrane-bound isoform</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NRG3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neuregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031508533.1">
        <property type="nucleotide sequence ID" value="XM_031652673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M2J2"/>
    <dbReference type="Ensembl" id="ENSPANT00000046308.2">
        <property type="protein sequence ID" value="ENSPANP00000029879.2"/>
        <property type="gene ID" value="ENSPANG00000022613.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012038"/>
    <dbReference type="CTD" id="10718"/>
    <dbReference type="GeneTree" id="ENSGT00940000156754"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022613">
        <property type="expression patterns" value="Expressed in Ammon's horn and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M2J2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038130">
        <property type="term" value="P:ERBB4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000267">
        <property type="entry name" value="pro-neuregulin-3, membrane-bound isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040180">
        <property type="entry name" value="Neuregulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11100">
        <property type="entry name" value="HEREGULIN-NEUREGULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11100:SF18">
        <property type="entry name" value="PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029879.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="696" mass="75090" checksum="26962A9AC6F4BE4E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7K3</accession>
    <name>A0A2I3M7K3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF134</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009193728.3">
        <property type="nucleotide sequence ID" value="XM_009195464.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021787194.2">
        <property type="nucleotide sequence ID" value="XM_021931502.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021787195.2">
        <property type="nucleotide sequence ID" value="XM_021931503.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M7K3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031721"/>
    <dbReference type="Ensembl" id="ENSPANT00000046595.2">
        <property type="protein sequence ID" value="ENSPANP00000031721.2"/>
        <property type="gene ID" value="ENSPANG00000036117.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101001534"/>
    <dbReference type="KEGG" id="panu:101001534"/>
    <dbReference type="CTD" id="7693"/>
    <dbReference type="GeneTree" id="ENSGT00940000154734"/>
    <dbReference type="OMA" id="RVCEEPH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000036117">
        <property type="expression patterns" value="Expressed in testis and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001478">
        <property type="entry name" value="Zinc finger protein 134"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002072">
        <property type="entry name" value="Zinc finger protein 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031721.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="427" mass="48533" checksum="3F3329C8E3161C0B" modified="2022-05-25" version="2">MTLVTAGGAWTGPGCWHGVKDEESSSEQSISIAVSHVNTSKAGLPTQTAYPCDICGPILKDILHLDEHQGTHHGLKLHTCGACGRQFWFRANLHQHQKCYSIEKPLRRDEGEASIVKNCTVSKEPHPSEKPFTCKEEQKNFQATLGGCQQRAIRSKRKTHRSTESGDAFHGEQMHYKCSECGKAFSRKDTLVQHQRIHSGEKPYECSECGKAFSRKATLVQHQRIHTGERPYECSECGKTFSRKDNLTQHKRIHTGEMPYKCNECGKYFSHHSNLIVHQRVHNGARPYKCSDCGKVFRHKSTLVQHESIHTGENPYDCSDCGKSFGHKYTLIKHQRIHTESKPFECIECGKFFSRSSDFIAHQRVHTGERPFVCSKCGKDFIRTSHLVRHQRVHTGERPYECSECGKAYSLSSHLNRHQKVHTAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MHZ3</accession>
    <name>A0A2I3MHZ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Methionine-R-sulfoxide reductase B1</fullName>
            <ecNumber evidence="6">1.8.4.12</ecNumber>
            <ecNumber evidence="5">1.8.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Selenoprotein X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:21260"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58773"/>
            <dbReference type="EC" id="1.8.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EC" id="1.8.4.14" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MHZ3"/>
    <dbReference type="Ensembl" id="ENSPANT00000042105.2">
        <property type="protein sequence ID" value="ENSPANP00000035334.1"/>
        <property type="gene ID" value="ENSPANG00000029688.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047678"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029688">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000008">
        <property type="entry name" value="methionine-R-sulfoxide reductase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052150">
        <property type="entry name" value="MsrB_Met_sulfoxide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755:SF5">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="21">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="115" mass="12620" checksum="976EA220EDFA8F41" modified="2018-02-28" version="1">MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRPEALKVSCGKCGNGLGHEFLNDGPKPGQSRFIFSSSLKFVPKGKETSASQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MPM6</accession>
    <name>A0A2I3MPM6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Synaptonemal complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SYCP1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MPM6"/>
    <dbReference type="Ensembl" id="ENSPANT00000052636.2">
        <property type="protein sequence ID" value="ENSPANP00000037571.1"/>
        <property type="gene ID" value="ENSPANG00000012296.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003368"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012296">
        <property type="expression patterns" value="Expressed in testis and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000801">
        <property type="term" value="C:central element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000802">
        <property type="term" value="C:transverse filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051878">
        <property type="term" value="P:lateral element assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000711">
        <property type="term" value="P:meiotic DNA repair synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008827">
        <property type="entry name" value="SYCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05483">
        <property type="entry name" value="SCP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
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                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
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                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
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                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Chau D.C."/>
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                <person name="Francis C.F."/>
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                <person name="Jhangiani S.J."/>
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                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
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                <person name="Lee S.L."/>
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                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
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                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MORF4 family-associated protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MRT7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000038483"/>
    <dbReference type="Ensembl" id="ENSPANT00000057574.2">
        <property type="protein sequence ID" value="ENSPANP00000038483.1"/>
        <property type="gene ID" value="ENSPANG00000035451.2"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101019021"/>
    <dbReference type="GeneTree" id="ENSGT00940000155541"/>
    <dbReference type="OMA" id="RITGCEC"/>
    <dbReference type="OrthoDB" id="9538419at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000035451">
        <property type="expression patterns" value="Expressed in amygdala and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029254">
        <property type="entry name" value="MRFAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31324:SF3">
        <property type="entry name" value="MORF4 FAMILY ASSOCIATED PROTEIN 1 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31324">
        <property type="entry name" value="MORF4 FAMILY-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15155">
        <property type="entry name" value="MRFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="119" mass="13343" checksum="86834C079481B18C" modified="2018-02-28" version="1">MRPVDADEAREPREDPGSPLSPVPRAGREDLASLERERARAHWRARRKLLEIQSLLDAIKSEVEAEERGARAPVPSPRAEAEERVARLCAEAERKAAEAARMGRRIVELHQRIAGCECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MTE7</accession>
    <name>A0A2I3MTE7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SPARC related modular calcium binding 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SMOC1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017816772.1">
        <property type="nucleotide sequence ID" value="XM_017961283.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MTE7"/>
    <dbReference type="Ensembl" id="ENSPANT00000052981.2">
        <property type="protein sequence ID" value="ENSPANP00000038940.2"/>
        <property type="gene ID" value="ENSPANG00000024307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015264"/>
    <dbReference type="CTD" id="64093"/>
    <dbReference type="GeneTree" id="ENSGT00390000018436"/>
    <dbReference type="OMA" id="GERDNHC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024307">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MTE7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045667">
        <property type="term" value="P:regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16240">
        <property type="entry name" value="EFh_SPARC_SMOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000076">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000012">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000003">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037639">
        <property type="entry name" value="SMOC1_EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF13">
        <property type="entry name" value="SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16597">
        <property type="entry name" value="Thyroglob_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="14">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="13">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="13">
        <location>
            <begin position="281"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038940.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="502" mass="55368" checksum="05C6F506573DB289" modified="2022-05-25" version="2">MTVSSARSLCEPPPQDRCPLPAAARAPSEGRKEARRAVRPAEPANPARCRLPSLAGTMLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDQTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVYSCDQERQSALEEARQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKSIEVDDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEDGSLGTVSPRENEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MU46</accession>
    <name>A0A2I3MU46_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2018-01" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="AHZZ02032167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MU46"/>
    <dbReference type="STRING" id="9555.ENSPANP00000039294"/>
    <dbReference type="Ensembl" id="ENSPANT00000026792">
        <property type="protein sequence ID" value="ENSPANP00000039294"/>
        <property type="gene ID" value="ENSPANG00000016044"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001424"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016044">
        <property type="expression patterns" value="Expressed in adrenal cortex"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF12">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="12051" checksum="53D9FB7E5B9A36B5" modified="2018-02-28" version="1">MAIQSVHCYSHGSHETDEEFDAVWVTYFNKPDIDAWELCKGVNTLVGYDLVPEQLNDVASAVHILEAVKDKAGPHREIYPYFTQELRLTLNELGIFTPEKLSLDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MW17</accession>
    <name>A0A2I3MW17_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">StAR related lipid transfer domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">STARD4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="PANTHER" id="PTHR47006:SF1">
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    <dbReference type="Pfam" id="PF01852">
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        <property type="entry name" value="Bet v1-like"/>
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    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="194" mass="22309" checksum="9167F7D49884818A" modified="2022-05-25" version="2">MEGLSDVASFATKLKNTLIQYHSIEEDKWRVAKKTKDVTVWRKPSEEFNGYLYKAQGVIDDLVNSIINHIRPGPCRLDWDSLMTSLDILENFEENCCVMRYTTAGQLWNIISPREFVDFSYTVGYKEGLLSGGISLDWDEKRPEFVRGYNHPCGWFCVPLKDNPNQSLLTGYIQTDLRGMIPQSAVDTAMQPEW</sequence>
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<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
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        <name evidence="8" type="primary">TM9SF2</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003914033.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NDT4"/>
    <dbReference type="SMR" id="A0A2I3NDT4"/>
    <dbReference type="Ensembl" id="ENSPANT00000031190.2">
        <property type="protein sequence ID" value="ENSPANP00000046150.2"/>
        <property type="gene ID" value="ENSPANG00000012681.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020546"/>
    <dbReference type="KEGG" id="panu:101020546"/>
    <dbReference type="CTD" id="9375"/>
    <dbReference type="GeneTree" id="ENSGT00940000157563"/>
    <dbReference type="OMA" id="KVYYMFG"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012681">
        <property type="expression patterns" value="Expressed in pyloric antrum and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NDT4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5035339682" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
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            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU363079"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="663" mass="75775" checksum="2B0986B1F6D27ACC" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MVV3</accession>
    <name>A0A8I5MVV3_PAPAN</name>
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        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MVV3"/>
    <dbReference type="Ensembl" id="ENSPANT00000083008.1">
        <property type="protein sequence ID" value="ENSPANP00000049101.1"/>
        <property type="gene ID" value="ENSPANG00000046529.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154179"/>
    <dbReference type="OMA" id="YNYVSWH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000442">
        <property type="entry name" value="Immunoglobulin lambda variable 2-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158744" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="197" mass="20989" checksum="A404BEA24C2DE702" modified="2022-05-25" version="1">MAWALVLLTLLTQGTGSWAQSALTQPPSVSGSPGQSVTISCTGTSSDVGGYNYVSWYQQHPGTAPKLMIYDVSNRPSGVSDRFSGSKSGNTASLTISGLQAEDEADYYCCSYTTSSTFHSGPSSWGTETKTCPGLSGSLSALKMLPHPVQGASCSMTFRILLSQLLSFPTMKSKRKPALWFLIQDRDSFLMLVCCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MW28</accession>
    <name>A0A8I5MW28_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Doublesex- and mab-3-related transcription factor C1/C2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MW28"/>
    <dbReference type="Ensembl" id="ENSPANT00000060752.2">
        <property type="protein sequence ID" value="ENSPANP00000049257.1"/>
        <property type="gene ID" value="ENSPANG00000046739.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163063"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031577">
        <property type="entry name" value="DMRT-C1/C2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15791">
        <property type="entry name" value="DMRT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Doublesex- and mab-3-related transcription factor C1/C2 C-terminal" evidence="5">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="127" mass="13494" checksum="08C7C333B16328C5" modified="2022-05-25" version="1">MAAPPKAPIRVRNLTIRAGVLTGKENNMLQPETHIFTASEEVPKVSDQALVSAHSEWQRKLEAAEALLTLRNSAQAPPDSISLHQPCNPPAPAGDKGFQPPSPSLRPRPASSISLPIGHLGCISLLS</sequence>
</entry>
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    <accession>A0A8I5MX77</accession>
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        <name evidence="11" type="primary">ECEL1</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neutral endopeptidase , domain2"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Peptidase_M13_C"/>
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    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
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    <dbReference type="PANTHER" id="PTHR11733:SF195">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME-LIKE 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="319"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="737"/>
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        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="51"/>
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        <location>
            <begin position="57"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="111"/>
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    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="182"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05649"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050181.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXT9</accession>
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        <alternativeName>
            <fullName evidence="21">Transglutaminase A chain</fullName>
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            <taxon>Cercopithecidae</taxon>
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    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="23">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Tetramer of two A chains (F13A1) and two B (F13B) chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5MXT9"/>
    <dbReference type="Ensembl" id="ENSPANT00000077629.1">
        <property type="protein sequence ID" value="ENSPANP00000050584.1"/>
        <property type="gene ID" value="ENSPANG00000017903.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244939"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072378">
        <property type="term" value="P:blood coagulation, fibrin clot formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000978">
        <property type="entry name" value="coagulation factor XIII A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001301">
        <property type="entry name" value="Coagulation factor XIII A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF42">
        <property type="entry name" value="COAGULATION FACTOR XIII A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="9 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="8 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="24">
        <location>
            <begin position="318"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="22">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="22">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="22">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00072805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="743" mass="84611" checksum="375CC703AC71878A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZ29</accession>
    <name>A0A8I5MZ29_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZ29"/>
    <dbReference type="Ensembl" id="ENSPANT00000076764.1">
        <property type="protein sequence ID" value="ENSPANP00000051594.1"/>
        <property type="gene ID" value="ENSPANG00000048751.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183016"/>
    <dbReference type="OMA" id="SEPYARI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="675" mass="77954" checksum="BF2711EBDE050045" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZ41</accession>
    <name>A0A8I5MZ41_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger B-box domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZBBX</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_009199675.1">
        <property type="nucleotide sequence ID" value="XM_009201411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZ41"/>
    <dbReference type="Ensembl" id="ENSPANT00000064675.1">
        <property type="protein sequence ID" value="ENSPANP00000051618.1"/>
        <property type="gene ID" value="ENSPANG00000024287.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008088"/>
    <dbReference type="KEGG" id="panu:101008088"/>
    <dbReference type="CTD" id="79740"/>
    <dbReference type="GeneTree" id="ENSGT00390000018298"/>
    <dbReference type="OMA" id="FTMGTNC"/>
    <dbReference type="OrthoDB" id="6226111at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19818">
        <property type="entry name" value="Bbox1_ZBBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037688">
        <property type="entry name" value="ZBBX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634:SF1">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="838" mass="95830" checksum="C68CFD87F851AA66" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N005</accession>
    <name>A0A8I5N005_PAPAN</name>
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        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HECTD1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with IGSF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="12"/>
    <dbReference type="Ensembl" id="ENSPANT00000064667.1">
        <property type="protein sequence ID" value="ENSPANP00000048745.1"/>
        <property type="gene ID" value="ENSPANG00000017149.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156572"/>
    <dbReference type="OMA" id="INHTLTM"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N273</accession>
    <name>A0A8I5N273_PAPAN</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N273"/>
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        <property type="protein sequence ID" value="ENSPANP00000049844.1"/>
        <property type="gene ID" value="ENSPANG00000038001.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="OMA" id="MNICFLF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035241812" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10204" checksum="37463B916CF68420" modified="2022-05-25" version="1">MNICFLFFFLRWNLTLSPRLECSGTILAHGNLYCLGSSDSPASASQVAGITGPCHHAWLIFVVFSRGGVSPSWQTLDFMIHLPRPPNVQGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N4R5</accession>
    <name>A0A8I5N4R5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892926.2">
        <property type="nucleotide sequence ID" value="XM_003892877.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510138.1">
        <property type="nucleotide sequence ID" value="XM_031654278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N4R5"/>
    <dbReference type="Ensembl" id="ENSPANT00000066755.1">
        <property type="protein sequence ID" value="ENSPANP00000054255.1"/>
        <property type="gene ID" value="ENSPANG00000050258.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000068233.1">
        <property type="protein sequence ID" value="ENSPANP00000055008.1"/>
        <property type="gene ID" value="ENSPANG00000043053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100999146"/>
    <dbReference type="GeneID" id="116270025"/>
    <dbReference type="KEGG" id="panu:100999146"/>
    <dbReference type="KEGG" id="panu:116270025"/>
    <dbReference type="GeneTree" id="ENSGT00940000158895"/>
    <dbReference type="OMA" id="CAKITVG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15914">
        <property type="entry name" value="7tmA_OR6N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF369">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="312" mass="35123" checksum="CDA98585E3D470D3" modified="2022-05-25" version="1">MDTGNWSQVTEFIILGFPHLQGVQIYLFLLLLLVYLTTMLANLLIFLVVCLDSQLHTPMYHFISILSFSELGYTAATTPKMLANLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICRPLHYPTLMTPTLCAEIAIGCWLGGLAGPVVEISLISRLPFCGPNRIQHIFCDFPPLLSLACTDTSINVLVDFVINSCKILATFLLILCSYVWIICTVLRIPSAAGKRKAFSTCASHLTVVLVFYGSILFMYVRLRKSYSLDYDRALAVVYSVLTPFLNPFIYSLRNKEIKEAMRRQLKRIGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N6P0</accession>
    <name>A0A8I5N6P0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N6P0"/>
    <dbReference type="Ensembl" id="ENSPANT00000066223.1">
        <property type="protein sequence ID" value="ENSPANP00000055109.1"/>
        <property type="gene ID" value="ENSPANG00000042806.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035312597" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="128" mass="14108" checksum="6625EC5A1F789C33" modified="2022-05-25" version="1">VNVSFVCLFVCFFFETESCSVPQAGVQWLDLSSLQAPPPGFTPFSCLSLQSSWDYRRPRRSLALSPRLECNGAISARCKVRLPGSRHSPASASRVAGTTGAHNRARLIFCIFFLVETGFHRGLDLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7T2</accession>
    <name>A0A8I5N7T2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7T2"/>
    <dbReference type="Ensembl" id="ENSPANT00000079982.1">
        <property type="protein sequence ID" value="ENSPANP00000049038.1"/>
        <property type="gene ID" value="ENSPANG00000040250.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="OMA" id="WPAWSRI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035308615" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15266" checksum="AC5DE4B8D1734847" modified="2022-05-25" version="1">MQGKFTSFFFFFFFFFSLRRSFALVAQAGVQWRDLGSPQPLPPEFKQFSCLSLPSSWDYRHAPPHPANFVFLVETKLLHVEAGLELLTSGDPPASASQSAGITGVSHRTRPNFCIFLRDRVSPCWPAWSRIPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N939</accession>
    <name>A0A8I5N939_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N939"/>
    <dbReference type="Ensembl" id="ENSPANT00000067329.1">
        <property type="protein sequence ID" value="ENSPANP00000057823.1"/>
        <property type="gene ID" value="ENSPANG00000040753.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004745"/>
    <dbReference type="OMA" id="LNIVLEW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="56" mass="6436" checksum="92FCC2C51CC79B57" modified="2022-05-25" version="1">MAILKMGLNIVLEWSGGHLSEDPSSYYLIILHKDTSSTLVDCHFQHHNLYKVGFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBJ0</accession>
    <name>A0A8I5NBJ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclosome subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ANAPC13</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895136.1">
        <property type="nucleotide sequence ID" value="XM_003895087.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003895138.1">
        <property type="nucleotide sequence ID" value="XM_003895089.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBJ0"/>
    <dbReference type="SMR" id="A0A8I5NBJ0"/>
    <dbReference type="Ensembl" id="ENSPANT00000082446.1">
        <property type="protein sequence ID" value="ENSPANP00000057593.1"/>
        <property type="gene ID" value="ENSPANG00000037430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025444"/>
    <dbReference type="KEGG" id="panu:101025444"/>
    <dbReference type="CTD" id="25847"/>
    <dbReference type="GeneTree" id="ENSGT00390000008673"/>
    <dbReference type="OMA" id="PHDDIAV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="74" mass="8521" checksum="F3C52A7E3821CB3B" modified="2022-05-25" version="1">MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC40</accession>
    <name>A0A8I5NC40_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrator complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003909746.1">
        <property type="nucleotide sequence ID" value="XM_003909697.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031518556.1">
        <property type="nucleotide sequence ID" value="XM_031662696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC40"/>
    <dbReference type="Ensembl" id="ENSPANT00000066834.1">
        <property type="protein sequence ID" value="ENSPANP00000058224.1"/>
        <property type="gene ID" value="ENSPANG00000040911.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000068646.1">
        <property type="protein sequence ID" value="ENSPANP00000051092.1"/>
        <property type="gene ID" value="ENSPANG00000048381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101012553"/>
    <dbReference type="GeneID" id="116273551"/>
    <dbReference type="KEGG" id="panu:101012553"/>
    <dbReference type="KEGG" id="panu:116273551"/>
    <dbReference type="CTD" id="80789"/>
    <dbReference type="GeneTree" id="ENSGT00390000008374"/>
    <dbReference type="OMA" id="KDFCVHS"/>
    <dbReference type="OrthoDB" id="69088at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029445">
        <property type="entry name" value="INTS5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14837">
        <property type="entry name" value="INTS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="107976" checksum="92A79991A76E022F" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC58</accession>
    <name>A0A8I5NC58_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC58"/>
    <dbReference type="Ensembl" id="ENSPANT00000061679.1">
        <property type="protein sequence ID" value="ENSPANP00000059113.1"/>
        <property type="gene ID" value="ENSPANG00000042490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="MAKLRCN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1096" mass="127985" checksum="11F2C522234CE613" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCR8</accession>
    <name>A0A8I5NCR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">E3 ubiquitin-protein ligase MIB1</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">DAPK-interacting protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">E3 ubiquitin-protein ligase mib1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mind bomb homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21 22">RING-type E3 ubiquitin transferase MIB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">MIB1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 30">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CEP131 and PCM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003914275.1">
        <property type="nucleotide sequence ID" value="XM_003914226.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCR8"/>
    <dbReference type="Ensembl" id="ENSPANT00000067717.1">
        <property type="protein sequence ID" value="ENSPANP00000051428.1"/>
        <property type="gene ID" value="ENSPANG00000024471.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999302"/>
    <dbReference type="KEGG" id="panu:100999302"/>
    <dbReference type="CTD" id="57534"/>
    <dbReference type="GeneTree" id="ENSGT00940000156781"/>
    <dbReference type="OMA" id="FFKPCGH"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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            <dbReference type="ARBA" id="ARBA00083489"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110150" checksum="D2BDE46F18DDD9A9" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NCU0</accession>
    <name>A0A8I5NCU0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine transporter 2</fullName>
            <shortName evidence="3">ThTr-2</shortName>
            <shortName evidence="3">ThTr2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Solute carrier family 19 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLC19A3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009181502.2">
        <property type="nucleotide sequence ID" value="XM_009183238.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009181503.2">
        <property type="nucleotide sequence ID" value="XM_009183239.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009181504.2">
        <property type="nucleotide sequence ID" value="XM_009183240.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017802527.2">
        <property type="nucleotide sequence ID" value="XM_017947038.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017802528.2">
        <property type="nucleotide sequence ID" value="XM_017947039.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779750.1">
        <property type="nucleotide sequence ID" value="XM_021924058.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031507418.1">
        <property type="nucleotide sequence ID" value="XM_031651558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NCU0"/>
    <dbReference type="Ensembl" id="ENSPANT00000082892.1">
        <property type="protein sequence ID" value="ENSPANP00000050580.1"/>
        <property type="gene ID" value="ENSPANG00000050314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101003441"/>
    <dbReference type="KEGG" id="panu:101003441"/>
    <dbReference type="CTD" id="80704"/>
    <dbReference type="GeneTree" id="ENSGT00950000183022"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028337">
        <property type="entry name" value="ThTr-2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF37">
        <property type="entry name" value="THIAMINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500795">
        <property type="entry name" value="Thiamine_transporter_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="496" mass="55885" checksum="3C680F20372794A5" modified="2022-05-25" version="1">MDCYRTSPSNSWIYPTVILCIFGFFSMMRPSEPFLIPYLSEPDKNLSSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTATEVAYYAYIYSVVSPEHYQRVSGYCRSVTLVAYTAGSVLAQLLVSLANLSYFYLNVISLASVSIAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPDCEKQKPTSEIPSTSGKLNKGQLNSLKPRNVTVEVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQILNYVQILWDYKAPSQDSSIYNGAVEATATFGGAVAAFAVGYVKVNWDLLGELALAVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLSVERYALVFGINTFIALVIQTIITVIVVDQRGLNLPISIQFLVYGSYFAVIAGIFLMRSMYIIYSTKSQKDVQSPAPSENPDMSHPEEESNVIMSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NDR2</accession>
    <name>A0A8I5NDR2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OTU domain-containing protein 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OTUD1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NDR2"/>
    <dbReference type="Ensembl" id="ENSPANT00000078619.1">
        <property type="protein sequence ID" value="ENSPANP00000055307.1"/>
        <property type="gene ID" value="ENSPANG00000039792.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000049635"/>
    <dbReference type="OMA" id="CTHYPSG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22747">
        <property type="entry name" value="OTU_OTUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000010">
        <property type="entry name" value="OTU domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047834">
        <property type="entry name" value="OTUD1_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF101">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="282"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="454" mass="48682" checksum="A8F479E058C9FAE4" modified="2022-05-25" version="1">MQLYSSVCTHYPSGAPGPTAAAPAPPAAAAPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPEPAPCTAGSSAWLLEELLRPDCPESAGLDATREGPDRNFRLSEHRQALAAAKHRGPAPTPGSPDPGPWGEEHLVERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPARSIETAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NDX3</accession>
    <name>A0A8I5NDX3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NDX3"/>
    <dbReference type="Ensembl" id="ENSPANT00000080071.1">
        <property type="protein sequence ID" value="ENSPANP00000052065.1"/>
        <property type="gene ID" value="ENSPANG00000041561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="OMA" id="HTQLFCI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266264" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9053" checksum="52D43434F80CD72F" modified="2022-05-25" version="1">MVFFCFFCFFCFFFFFLRESLTLYPRLECSGRISAHCKLRLPGSRHSPASASRVAGTTGARHLAQLVFCIFSRDRVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NEY7</accession>
    <name>A0A8I5NEY7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Malate dehydrogenase [quinone] cytochrome b560 subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NEY7"/>
    <dbReference type="Ensembl" id="ENSPANT00000070905.1">
        <property type="protein sequence ID" value="ENSPANP00000061080.1"/>
        <property type="gene ID" value="ENSPANG00000043226.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000566"/>
    <dbReference type="OMA" id="IFPLMYH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.540:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.540">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="129" mass="14251" checksum="6135F79310A681B0" modified="2022-05-25" version="1">MAALLLRHVGRHCLRAHFSPQLCIRNAIPLGTTAKEEMEWFWNKNIMGSNRPVSPHITIYSWSLPMAMSICHSGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHKAKFALVFPLMYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFB1</accession>
    <name>A0A8I5NFB1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NFB1"/>
    <dbReference type="Ensembl" id="ENSPANT00000083948.1">
        <property type="protein sequence ID" value="ENSPANP00000052954.1"/>
        <property type="gene ID" value="ENSPANG00000045620.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286925"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="663" mass="77732" checksum="95CA9C07D0A4734E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGI0</accession>
    <name>A0A8I5NGI0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OR4K5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A8I5NGI0"/>
    <dbReference type="SMR" id="A0A8I5NGI0"/>
    <dbReference type="Ensembl" id="ENSPANT00000076027.1">
        <property type="protein sequence ID" value="ENSPANP00000053782.1"/>
        <property type="gene ID" value="ENSPANG00000044943.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000163286"/>
    <dbReference type="OMA" id="IVTHYLR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15226">
        <property type="entry name" value="7tmA_OR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000012">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="120"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="141"/>
            <end position="158"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="323" mass="36238" checksum="7ACB0BA6F00BD697" modified="2022-05-25" version="1">MDKANSSVVSEFVLLGLCSSQNLQLFYFVFFSVLYMVIVLGNLLIILTVTFDTSLHSPMYFLLGNLSFIDICQASFATPKMIADFLSEHKTISFSGCIAQIFFVHLFTGGEMVLLVSMAYDRYVAICKPLYYVIIMSRRTCTVLVTISWAVGLVHTLSQLSFTVNLPFCGPNVVDSFFCDLPRVTKLACLDSNIIEILIVVNSGVLSLSTFSLLVSSYIIILVTVLLKSSAAMAKAFSTLASHIAVVILFFGPCIFIYVWPFTIYPVDKLLDIFYTVFTPILNPIIYTLRNRDMKAAIRKIVNYYLRPRIISEMSLVVRTSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NJ78</accession>
    <name>A0A8I5NJ78_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic leucine zipper and W2 domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BZW1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907838.1">
        <property type="nucleotide sequence ID" value="XM_003907789.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009180983.1">
        <property type="nucleotide sequence ID" value="XM_009182719.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJ78"/>
    <dbReference type="SMR" id="A0A8I5NJ78"/>
    <dbReference type="Ensembl" id="ENSPANT00000065022.1">
        <property type="protein sequence ID" value="ENSPANP00000049631.1"/>
        <property type="gene ID" value="ENSPANG00000016459.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003319"/>
    <dbReference type="KEGG" id="panu:101003319"/>
    <dbReference type="CTD" id="9689"/>
    <dbReference type="GeneTree" id="ENSGT00390000012561"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000006">
        <property type="entry name" value="Basic leucine zipper and W2 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF0">
        <property type="entry name" value="EIF5-MIMIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="247"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="419" mass="48073" checksum="9E952D52E9096F60" modified="2022-05-25" version="1">MNNQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLTETGTDLEAVAKFLDASGAKLDYRRYAETLFDILVAGGMLAPGGTLADDMMRTDVCVFAAQEDLETMQAFAQVFNKLIRRYKYLEKGFEDEVKKLLLFLKGFSESERNKLAMLTGVLLANGTLNASILNSLYNENLVKEGVSAAFAVKLFKSWINEKDINAVAASLRKVSMDNRLMELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIVWSSVMSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWLKNAEEESESETEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NM08</accession>
    <name>A0A8I5NM08_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NM08"/>
    <dbReference type="Ensembl" id="ENSPANT00000079122.1">
        <property type="protein sequence ID" value="ENSPANP00000054387.1"/>
        <property type="gene ID" value="ENSPANG00000048949.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="PHLDNFC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035219861" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11470" checksum="EF56279335CCBA7E" modified="2022-05-25" version="1">MDMFFVLFCFVLFLRWSLTVAQAGAQWCNLGSLQPPPPGFKRFFCLSLLSSRDYRYAPPRLANFCIFSRDGVSPYWPGWSQTPDLMIHPPRPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NSU5</accession>
    <name>A0A8I5NSU5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Olfactory receptor family 1 subfamily A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">OR1A2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSU5"/>
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        <property type="protein sequence ID" value="ENSPANP00000054434.1"/>
        <property type="gene ID" value="ENSPANG00000007880.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141057"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000082">
        <property type="entry name" value="Olfactory receptor 1A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="43"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="311" mass="34297" checksum="78C2C4D04FC9DCAD" modified="2022-05-25" version="1">MTKKNQTMISEFLKKINSLTGQHEQNNVVFVIFLCIYPISLTGNLLIILAIQADIRLHNPMYFFLVNLSLVDIFSSSVSIPKILVNHLLGSKSISFGGCLTQMYFMIALAKADSYTLAAMAYDRAVAISRPLHYTTIMSPRSCVLLVVGSWAIGNASALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIGFNVKMMYVGVGVFSVPLLCIIVSYVQVFSTVFQVPSTKSLFKAASTCGSHLTVVFLYYGTTMGMYLRPLTGYSPKDAVITVMYVAVTPALNPFIYSLRKRDMKAALRKLFSKRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NSX2</accession>
    <name>A0A8I5NSX2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSX2"/>
    <dbReference type="Ensembl" id="ENSPANT00000081013.1">
        <property type="protein sequence ID" value="ENSPANP00000054482.1"/>
        <property type="gene ID" value="ENSPANG00000044258.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183010"/>
    <dbReference type="OMA" id="EDHPLGN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="172" mass="20006" checksum="7521335B03449634" modified="2022-05-25" version="1">MSHHTQGSNLRVHFKNTHETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUX8</accession>
    <name>A0A8I5NUX8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinoic acid induced 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RAI2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUX8"/>
    <dbReference type="Ensembl" id="ENSPANT00000015464.3">
        <property type="protein sequence ID" value="ENSPANP00000061252.1"/>
        <property type="gene ID" value="ENSPANG00000015463.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154164"/>
    <dbReference type="OMA" id="QHKWLVD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026092">
        <property type="entry name" value="RAI2/SOBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23186">
        <property type="entry name" value="RETINOIC ACID-INDUCED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23186:SF3">
        <property type="entry name" value="RETINOIC ACID-INDUCED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15279">
        <property type="entry name" value="SOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="480" mass="52065" checksum="61D75BE60CB14894" modified="2022-05-25" version="1">MDNLQSQNLSMDMTDSPPALANNRLENGMAQLITTEAWNINSTDLVEGSSAPELNPNGNATYVMTTQGPVQLPVVLEQHVFQHLNSPLVLPQEAPCSSNTIHNNLFQGAEDSEAQPQLLDLRIPSQPQEPTLPFEAVLQNLFPSQGTLGPPPCQPPPGYAPVPPQPFSSPLSPLVPPATLLVPYPVIVPLPVPVPIPIPIPVPQSSESKFSSSFPKPPSSFGLHPFKGTQTPLEKDELKPFDILQPKEYFQLSRHTVIKMGSENEALDLSMKSVPWLKAGEVSPPIFQEDAALDLSVAAHRKSEPPPETLYDSGASVDSSGHTVMEKLPSGMEISFAPTTSHEAPAMIDSHISSSDAATEMLSQPNHASSEVKTENNIEMVGESQAAKVIVSVEDAVPTIFCGKIKGLSGVSTKNFSFKREDSVLQGYDINSQGEESMGNAEPLRKPIKNRSIKLKKVNSQEIHMLPIKKQRLATFFPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NVI9</accession>
    <name>A0A8I5NVI9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NVI9"/>
    <dbReference type="Ensembl" id="ENSPANT00000077158.1">
        <property type="protein sequence ID" value="ENSPANP00000054402.1"/>
        <property type="gene ID" value="ENSPANG00000047398.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="116" mass="12959" checksum="9218F13713256DC8" modified="2022-05-25" version="1">IFPRLEFSGAISAHCKLCLLCSCHSPASASRLAGTTGAHHHGWIIFCVFGRDRVSFFFFFFFETESRSVAQAGVQWPDLSSLQAPPPGFTPFSGLSLPSSWDYRRPPPRPAKFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXK5</accession>
    <name>A0A8I5NXK5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LysM and putative peptidoglycan-binding domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LYSMD3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential for Golgi structural integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NXK5"/>
    <dbReference type="Ensembl" id="ENSPANT00000075523.1">
        <property type="protein sequence ID" value="ENSPANP00000061064.1"/>
        <property type="gene ID" value="ENSPANG00000008951.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158711"/>
    <dbReference type="OMA" id="IQINFIV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF5">
        <property type="entry name" value="AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="12">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="408" mass="45927" checksum="114BD0D3E42036EF" modified="2022-05-25" version="1">MHSKKKMQDSSRTHPEPRLVLRVPPTVSASSVWSLDKDAASLRTWRRRTARKAETLAAEAEADWVSPRRRLDYELARDSGGDGPFGHLVAACPLLTRTDFNIMAGRHQNRSFPLPGVQSSGQVHAFGNCSDSDMLEEDAEVYELRSRGKEKVRRSTSRDRLDDIIVLTKDIQEGDTLNAIALQYCCTVADIKRVNNLISDQDFFALRSIKIPVKKFSSLTETLCPPKGRQTSRHSSVQYSSEQQEILPANDSLAYSDSAGSFLKEVDRDIEQIVKCTDNKRENLNEVVSALTAQQIHFEPDNKNTQRKDPYYGADWGIGWWTAVVIMLIVGIITPVFYLLYYEILAKVDVSHHSTVDSSHLHSKITPPSQQREMENGIVPTKGIHFGQQDDNKLYSQDSQSPAAQHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NZQ1</accession>
    <name>A0A8I5NZQ1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NZQ1"/>
    <dbReference type="Ensembl" id="ENSPANT00000060837.1">
        <property type="protein sequence ID" value="ENSPANP00000061124.1"/>
        <property type="gene ID" value="ENSPANG00000041553.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="KNINLMA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="356"/>
            <end position="631"/>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061124.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="933" mass="109289" checksum="C438743DF53AE0F6" modified="2022-05-25" version="1"> </sequence>
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    <accession>A0A8I5P064</accession>
    <name>A0A8I5P064_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P064"/>
    <dbReference type="Ensembl" id="ENSPANT00000077465.1">
        <property type="protein sequence ID" value="ENSPANP00000057234.1"/>
        <property type="gene ID" value="ENSPANG00000048645.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00860000134306"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="107" mass="11811" checksum="035FC88A619F5D01" modified="2022-05-25" version="1">MSHPTLELVMWPQSTVRGVGGQMEYLGSTPVSQTSSGRNTTAHTAKEHKPTRKPFYSSINSFMKAEPSGRARWLKPVIPALWEAEAGGSRGQEIETILANTVKPRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R0L7</accession>
    <name>A0A8I5R0L7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyacid-oxoacid transhydrogenase, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="9">Alcohol dehydrogenase iron-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADHFE1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
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                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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                <person name="Schneider B.S."/>
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                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Walker D.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003902867.1">
        <property type="nucleotide sequence ID" value="XM_003902818.3"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPANT00000074300.1">
        <property type="protein sequence ID" value="ENSPANP00000053281.1"/>
        <property type="gene ID" value="ENSPANG00000026368.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997709"/>
    <dbReference type="KEGG" id="panu:100997709"/>
    <dbReference type="CTD" id="137872"/>
    <dbReference type="GeneTree" id="ENSGT00390000003849"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000010">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
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    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="11">
        <location>
            <begin position="53"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="274"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="467" mass="50217" checksum="38071EBEDEAD49C8" modified="2022-05-25" version="1">MAAAARARVAHLLRQLQRAACQCPTHSHTYSQAPGLSPSGKTTDYAFEMAVSNIRYGAGVTKEVGMDLQNMGAKNVCLMTDKNLSQLPPVQVAMDSLVKNGIPFTVYDNVRVEPTDASFMEAIEFAQKGAFDAYVAVGGGSTMDTCKAANLYASSPHSDFLDYVSAPIGKGKPVSVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKTGIASRAIKPTLGLIDPLHTLHMPARVVANSGFDVLCHALESYTALPYHLRSPCPSNPITRPAYQGSNPISDIWAIHALRIVAKYLKRAVRNPDDLEARSHMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKTYKAKDYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLETAEILGADTRTTRIQDAGLVLADTLRKFLFDLDVDDGLAAIGYSKADIPALVKGTLPQERVTKLAPRPQSEEDLAALFEASMKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R0U6</accession>
    <name>A0A8I5R0U6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R0U6"/>
    <dbReference type="Ensembl" id="ENSPANT00000064805.1">
        <property type="protein sequence ID" value="ENSPANP00000054133.1"/>
        <property type="gene ID" value="ENSPANG00000049137.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170471"/>
    <dbReference type="OMA" id="CAGLAFH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="110" mass="12241" checksum="390F5030660F192E" modified="2022-05-25" version="1">ETRWSLSLVDQAVVQWGDLGSSQPPPPGFKRFSFFSLPSSWDYRHAPPRPANFVFVVEMGFLHVGQVGLELLTSGDPPTLASQSAGITGMSHHAWPRKTLFLRILHTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R155</accession>
    <name>A0A8I5R155_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R155"/>
    <dbReference type="Ensembl" id="ENSPANT00000070673.1">
        <property type="protein sequence ID" value="ENSPANP00000055081.1"/>
        <property type="gene ID" value="ENSPANG00000047631.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000171576"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="11873" checksum="1C66F8E2CA362025" modified="2022-05-25" version="1">MQKTSGGGRALNPNWFQCLYSTCQREALTFCSPSKKQLGTRYFSPQARHRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGKLLDSAVFSQFLVFHVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R5K4</accession>
    <name>A0A8I5R5K4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute carrier family 35 member F4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLC35F4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Munidasa M.M."/>
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                <person name="Nguyen T.N."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
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                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
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                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Onwere C.O."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
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                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
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                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
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                <person name="Fernandez S.F."/>
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                <person name="Forbes L.F."/>
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                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Jones J.J."/>
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                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R7K1"/>
    <dbReference type="Ensembl" id="ENSPANT00000072346.1">
        <property type="protein sequence ID" value="ENSPANP00000054068.1"/>
        <property type="gene ID" value="ENSPANG00000050882.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="OMA" id="CAPPWAK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="123" mass="13929" checksum="D96C2912CD27D34E" modified="2022-05-25" version="1">IFDRDCIDPIYFFFFFFFFFFFRQSLALSPRLECSGRISAHCKLRLPGLRHSPASASRVAGTTGARHLGRLRQENGVNPGGGACSELRSGHCTPAWVTERDSVSKNNNNNNNNKKKTEVYHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R8D7</accession>
    <name>A0A8I5R8D7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GIPC PDZ domain containing family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R8D7"/>
    <dbReference type="Ensembl" id="ENSPANT00000073415.1">
        <property type="protein sequence ID" value="ENSPANP00000055928.1"/>
        <property type="gene ID" value="ENSPANG00000038587.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003420"/>
    <dbReference type="OMA" id="EQAPSEF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF2">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN GIPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIPC1-3 GH1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GIPC GH2" evidence="2">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="298" mass="32177" checksum="3F2AD73D89565FE5" modified="2022-05-25" version="1">MEGAAAREARGAEAPRASAPPPAPSEPPAAPRARPRLVFRTQLAHGSPTGKIEGFTNVRELYAKIAEAFGIAPTEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVHSIVQARLVASQGLQRCGSTQNPWPSLTLFSPDMIGQRSRSSKCPVEAKVTSGRETLRLRSGGAATVEEAPSEFEEEASQKVDDLLESYMGIRDPELASTMVETSKKTVSAQEFARCLDSVLGEFAFPDEFVVEVWAAISEAREACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R9M4</accession>
    <name>A0A8I5R9M4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R9M4"/>
    <dbReference type="Ensembl" id="ENSPANT00000072096.1">
        <property type="protein sequence ID" value="ENSPANP00000059661.1"/>
        <property type="gene ID" value="ENSPANG00000045266.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163244"/>
    <dbReference type="OMA" id="WWHTSVI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="76" mass="8631" checksum="5A190437109A00FA" modified="2022-05-25" version="1">CSQVRWLLPVIPGLWETEASGSPEVGSLRPAWSTCQNPISTKNTKISWVSWHMPVIPATWEAEVGESLEPRRQRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLU6</accession>
    <name>A0A096MLU6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small integral membrane protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SMIM11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MLU6"/>
    <dbReference type="Ensembl" id="ENSPANT00000002948.3">
        <property type="protein sequence ID" value="ENSPANP00000000538.2"/>
        <property type="gene ID" value="ENSPANG00000003351.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023466"/>
    <dbReference type="KEGG" id="panu:101023466"/>
    <dbReference type="CTD" id="54065"/>
    <dbReference type="eggNOG" id="ENOG502SFJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00640000091610"/>
    <dbReference type="HOGENOM" id="CLU_196183_0_0_1"/>
    <dbReference type="OMA" id="TKMINWK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003351">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 35 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MLU6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042125">
        <property type="entry name" value="SMIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35975:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35975">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14981">
        <property type="entry name" value="FAM165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000538.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="58" mass="6838" checksum="8D98D8A9E96E5854" modified="2018-02-28" version="2">MNWKVLEHVPLLLYILAAKTLILCLAFAGVKIYQRKRLEAKQQKLEAERKKQSEKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNZ0</accession>
    <name>A0A096MNZ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger and BTB domain-containing protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Zinc finger protein 482</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZBTB6</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003911310.1">
        <property type="nucleotide sequence ID" value="XM_003911261.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017805067.1">
        <property type="nucleotide sequence ID" value="XM_017949578.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNZ0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001422"/>
    <dbReference type="Ensembl" id="ENSPANT00000018036.3">
        <property type="protein sequence ID" value="ENSPANP00000001422.1"/>
        <property type="gene ID" value="ENSPANG00000016323.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014956"/>
    <dbReference type="KEGG" id="panu:101014956"/>
    <dbReference type="CTD" id="10773"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161459"/>
    <dbReference type="HOGENOM" id="CLU_037856_1_0_1"/>
    <dbReference type="OMA" id="TEMSGNH"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016323">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18197">
        <property type="entry name" value="BTB_POZ_ZBTB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000333">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000047">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001873">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF29">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="16">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="424" mass="48135" checksum="83D56D9AC11B88A3" modified="2014-11-26" version="1">MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEDENSDKDCEIIEISEDSPVNIDFHVKEEESNALQSTVESLTSERKEMESPELSAVDIGFKDNEICILHVESISTAGVENGQFSQPCTSSKASMYFSETQHSLINSTVESRVAEVPGNQGQGLFCENTEGSYGTVSEIQNLEEGYSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCSVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKRQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQ17</accession>
    <name>A0A096MQ17_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ING2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899445.1">
        <property type="nucleotide sequence ID" value="XM_003899396.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQ17"/>
    <dbReference type="SMR" id="A0A096MQ17"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001839"/>
    <dbReference type="Ensembl" id="ENSPANT00000027925.3">
        <property type="protein sequence ID" value="ENSPANP00000001839.1"/>
        <property type="gene ID" value="ENSPANG00000009492.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017834"/>
    <dbReference type="KEGG" id="panu:101017834"/>
    <dbReference type="CTD" id="3622"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158194"/>
    <dbReference type="HOGENOM" id="CLU_031900_5_0_1"/>
    <dbReference type="OMA" id="QCFQDPS"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009492">
        <property type="expression patterns" value="Expressed in pancreas and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048133">
        <property type="term" value="P:male germ-line stem cell asymmetric division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030511">
        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16861">
        <property type="entry name" value="ING_ING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15683">
        <property type="entry name" value="PHD_ING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000021">
        <property type="entry name" value="Inhibitor of growth 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042019">
        <property type="entry name" value="ING2_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF37">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="280" mass="32808" checksum="DC85A6ECAF7A5D81" modified="2014-11-26" version="1">MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDLNQKKRLQQLLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSRRPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKDRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQF6</accession>
    <name>A0A096MQF6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CCDC65</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the nexin-dynein regulatory complex (N-DRC). Interacts with DRC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MQF6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001983"/>
    <dbReference type="Ensembl" id="ENSPANT00000027889.3">
        <property type="protein sequence ID" value="ENSPANP00000001983.3"/>
        <property type="gene ID" value="ENSPANG00000019461.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153804"/>
    <dbReference type="HOGENOM" id="CLU_026536_1_0_1"/>
    <dbReference type="OMA" id="WEYLDLF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019461">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 26 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="15">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001983.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="497" mass="58512" checksum="C518289A6405B19C" modified="2022-05-25" version="3">MPKKEKKAKAPLSDEEQLLLFQQKLLAEEEMAKKKERLLSQFLKDKLTKEEHNSALNLNKINTQWRTVLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYARALRSHLHNVDQLLALQRHRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDSEYESKLEFQSMWNDLKNMNLEEKHFLRLHLENIVEDLWRKFQDVLKNYTDATEDRKAAFETLQVKDEKSSKEIEVQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRNDKELVLVQLRKLKAQRTQARAASQKNLVKLTLESNATLKALRKIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEGIEENNLEELTEELAKVMVDYTGMENFWKRYNKVKLEQLSLQHRRAQLLDINGKLREMLKQYLDGISVSDEVLSQLNPLFIVNYQSNLPQPLSIPIAHPGSTSPPAPWSDQRRSFFLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQN5</accession>
    <name>A0A096MQN5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline rich 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRR27</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MQN5"/>
    <dbReference type="Ensembl" id="ENSPANT00000018563.3">
        <property type="protein sequence ID" value="ENSPANP00000002068.3"/>
        <property type="gene ID" value="ENSPANG00000018382.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SCUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064615"/>
    <dbReference type="HOGENOM" id="CLU_111396_0_0_1"/>
    <dbReference type="OMA" id="PPRDFPF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018382">
        <property type="expression patterns" value="Expressed in smooth muscle tissue and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033533">
        <property type="entry name" value="PRR27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39415">
        <property type="entry name" value="PROLINE-RICH PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39415:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199421" evidence="2">
        <location>
            <begin position="16"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002068.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="249" mass="26127" checksum="3DFEA6E6ED2B4B91" modified="2022-05-25" version="3">MKLLLWACIVCVAFARKRRFPFNDEDYNDYHHPLHPSLNIPYGIRNLPPPLYYPPVNTVPNYPGNTYTDTRLPPYPWILTSPGFRYVYHIPGFPLATRLNVPPLPPRDFPFVPPSRIFSAPAAPASPPIAAKPDAAAPPTVTPVAADPAAEAPVAAKPAAEALIGAEPAAEAPVGAETAAEAPVGAEPVAEAPVGAEPAAEAPAGAEPAADSPSPAEPATAKPAAPEPHPSPSLHQVGCLYLTTITYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQT6</accession>
    <name>A0A096MQT6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium channel tetramerization domain containing 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KCTD18</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003907834.1">
        <property type="nucleotide sequence ID" value="XM_003907785.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003907835.1">
        <property type="nucleotide sequence ID" value="XM_003907786.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009180976.1">
        <property type="nucleotide sequence ID" value="XM_009182712.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQT6"/>
    <dbReference type="Ensembl" id="ENSPANT00000006969.3">
        <property type="protein sequence ID" value="ENSPANP00000002120.3"/>
        <property type="gene ID" value="ENSPANG00000021439.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001690"/>
    <dbReference type="KEGG" id="panu:101001690"/>
    <dbReference type="CTD" id="130535"/>
    <dbReference type="eggNOG" id="KOG2723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064234"/>
    <dbReference type="HOGENOM" id="CLU_052824_0_0_1"/>
    <dbReference type="OMA" id="CKAGPKP"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021439">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQT6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18372">
        <property type="entry name" value="BTB_POZ_KCTD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045704">
        <property type="entry name" value="KCTD18_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF4">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19321">
        <property type="entry name" value="KCTD18_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BTB/POZ" evidence="3">
        <location>
            <begin position="114"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002120.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="426" mass="46677" checksum="AD59E9950C6EE57B" modified="2022-05-25" version="3">MEGHKAGEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGRLFKYLLDYLHGEVQIPTDEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNTSGASCESRIIGVYATKTDGTDAIDKQLGGRIHSKSIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYWRVPHELIECWTLEERPLLGSLRHMAPIRKRRLITFNEEDEGVNCKTGPKPVRFLGPSTSTQIKVKNSASVTVSPGSAVQTSAGATAYRFQSGSRRKAAQRSAPSRTTALEGTGAPGHPQASLGAASAENGGTHLPPAKVLLSDKKPTPQRVIKLKRTPLCATAPSLATPTAARQANSLKPLPGDAARALGVRTENGKDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRK4</accession>
    <name>A0A096MRK4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Elongation of very long chain fatty acids protein 6</fullName>
            <ecNumber evidence="19">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">3-keto acyl-CoA synthase ELOVL6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ELOVL fatty acid elongase 6</fullName>
            <shortName evidence="19">ELOVL FA elongase 6</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Very long chain 3-ketoacyl-CoA synthase 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Very long chain 3-oxoacyl-CoA synthase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">ELOVL6</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:76555"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39676"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74011"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:36512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36503"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74012"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:36504"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74034"/>
            <dbReference type="ChEBI" id="CHEBI:74054"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:36524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:60140"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60141"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctadecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35315"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:35316"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:39168"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Endoplasmic reticulum membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="19">N-Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ELO family. ELOVL6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="19"/>
    <dbReference type="RefSeq" id="XP_017814453.1">
        <property type="nucleotide sequence ID" value="XM_017958964.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRK4"/>
    <dbReference type="SMR" id="A0A096MRK4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002406"/>
    <dbReference type="Ensembl" id="ENSPANT00000012625.3">
        <property type="protein sequence ID" value="ENSPANP00000002406.1"/>
        <property type="gene ID" value="ENSPANG00000009911.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999068"/>
    <dbReference type="KEGG" id="panu:100999068"/>
    <dbReference type="CTD" id="79071"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244965"/>
    <dbReference type="HOGENOM" id="CLU_048483_1_1_1"/>
    <dbReference type="OMA" id="PISWVPI"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009911">
        <property type="expression patterns" value="Expressed in white adipose tissue and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009923">
        <property type="term" value="C:fatty acid elongase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03206">
        <property type="entry name" value="VLCF_elongase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033675">
        <property type="entry name" value="ELOVL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF125">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 19 20" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 19 20" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 19 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 19 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
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    <accession>A0A096MRY5</accession>
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        <name evidence="5" type="primary">C5orf34</name>
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        <name type="scientific">Papio anubis</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
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                <person name="Davy-Carroll L.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gubbala S.G."/>
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                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
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                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
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                <person name="Mathew T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Akbar H.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003905809.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MSY6"/>
    <dbReference type="Ensembl" id="ENSPANT00000020142.3">
        <property type="protein sequence ID" value="ENSPANP00000002910.3"/>
        <property type="gene ID" value="ENSPANG00000016863.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997601"/>
    <dbReference type="KEGG" id="panu:100997601"/>
    <dbReference type="CTD" id="101929469"/>
    <dbReference type="eggNOG" id="ENOG502S25Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006066"/>
    <dbReference type="HOGENOM" id="CLU_087011_0_0_1"/>
    <dbReference type="OMA" id="QHTWGFH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016863">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029206">
        <property type="entry name" value="DUF4532"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35156">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35156:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15046">
        <property type="entry name" value="DUF4532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002910.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="305" mass="35283" checksum="83131256E0879662" modified="2022-05-25" version="3">MASSRQRSLRGPSHPPHMEEPFLQMVQASESLPPSQTWAQREFFLPSESWEFPGFTRQAYHQLALKLPPCTDMKSKVRQRLIHPWKGGAQHTWGFHTWLDVCRLPATFPTRPDRPYDSNVWRWLTDSNAHRRPPTEHPIPPPSWMGQNSFLTFIHCYPTFVDMKRKKQVIFRTVKELKEVEKLKLRSEARAPPLDAQGNIQPPASFKKYRHISAGGRFEPQGLRLMPNPFPNNFARSWPCPNPLPHYQEKVLKLVLLPSAPLSQDLIRDFQTLLKDRTASPLHHLSKAQASKTPARKRKGRPGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUF9</accession>
    <name>A0A096MUF9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAZ-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deleted in azoospermia-associated protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline-rich transcript in brain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DAZAP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003906434.1">
        <property type="nucleotide sequence ID" value="XM_003906385.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MUF9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003460"/>
    <dbReference type="Ensembl" id="ENSPANT00000001803.3">
        <property type="protein sequence ID" value="ENSPANP00000003460.3"/>
        <property type="gene ID" value="ENSPANG00000017307.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015745"/>
    <dbReference type="KEGG" id="panu:101015745"/>
    <dbReference type="CTD" id="9802"/>
    <dbReference type="eggNOG" id="ENOG502QTNQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000685"/>
    <dbReference type="HOGENOM" id="CLU_135110_0_0_1"/>
    <dbReference type="OMA" id="YPQTMPL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017307">
        <property type="expression patterns" value="Expressed in cornea and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MUF9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031435">
        <property type="term" value="F:mitogen-activated protein kinase kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120283">
        <property type="term" value="F:protein serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022730">
        <property type="entry name" value="DAZ_assoc-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638:SF3">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11029">
        <property type="entry name" value="DAZAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003460.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="168" mass="17349" checksum="49E0E39690B70EAC" modified="2022-05-25" version="3">MNSKGQYPTQPTYPVQPPGNPVYPQTLHLPQAPPYTDAPPAYSELYRPSFVHPGAATVPTMSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVSPIYPPGSTVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVA9</accession>
    <name>A0A096MVA9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thrombospondin type 1 domain containing 7B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">THSD7B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A096MVA9"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
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        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
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        <property type="entry name" value="TSP1_rpt"/>
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        <property type="entry name" value="TSP1_rpt_sf"/>
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        <property type="entry name" value="TSP1_spondin_dom"/>
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        <property type="entry name" value="SPONDIN"/>
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        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 7B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
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    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
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        <property type="entry name" value="TSP1"/>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
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    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="199"/>
            <end position="249"/>
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    <feature type="domain" description="Spondin-like TSP1" evidence="4">
        <location>
            <begin position="356"/>
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    <feature type="domain" description="Spondin-like TSP1" evidence="4">
        <location>
            <begin position="621"/>
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    <feature type="domain" description="Spondin-like TSP1" evidence="4">
        <location>
            <begin position="757"/>
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    <feature type="domain" description="Spondin-like TSP1" evidence="4">
        <location>
            <begin position="1020"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="Pfam" id="PF19028"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003784.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="1182" mass="131722" checksum="77956151F0AE9431" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWH5</accession>
    <name>A0A096MWH5_PAPAN</name>
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        <recommendedName>
            <fullName evidence="9">Alcohol dehydrogenase 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ADH6</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Alcohol dehydrogenase. Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes. Oxidizes secondary alcohols to the corresponding ketones.</text>
    </comment>
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        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003898996.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A096MWH5"/>
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        <property type="protein sequence ID" value="ENSPANP00000004231.1"/>
        <property type="gene ID" value="ENSPANG00000017466.3"/>
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    <dbReference type="GeneID" id="101014386"/>
    <dbReference type="KEGG" id="panu:101014386"/>
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    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000163645"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="Bgee" id="ENSPANG00000017466">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="alcohol_DH_class_I_II_IV"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADH-like_C"/>
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    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
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        <property type="entry name" value="ADH_Zn_CS"/>
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        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF20">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="11">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="374" mass="39546" checksum="2970FCC702DCB85C" modified="2014-11-26" version="1">MNTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKILGSKHLDLLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQVKQSKPQLMSDGTSRFTCNGKSIYHFGNTSTFSEYTVIKEISVAKIDAVAPLDKVCLISCGFSTGFGAAINTAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATECLNPLDLKKPIQEVLFDMTDSGIDFCFEAIGNLDTLAAALASCNESYGVCVVVGVLPAGGQLNISGQLFSGRSLKGSVFGGWKSREHIPKLVADYMAEKLNLDPLITHTRSLDKINEAVELMKTGKCIRCILIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXM9</accession>
    <name>A0A096MXM9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 22">Exonuclease 1</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">EXO1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="22">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A096MXM9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004652"/>
    <dbReference type="Ensembl" id="ENSPANT00000019387.3">
        <property type="protein sequence ID" value="ENSPANP00000004652.3"/>
        <property type="gene ID" value="ENSPANG00000005526.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047676"/>
    <dbReference type="HOGENOM" id="CLU_009851_0_0_1"/>
    <dbReference type="OMA" id="AFCMKLV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005526">
        <property type="expression patterns" value="Expressed in ascending colon and 30 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002455">
        <property type="term" value="P:humoral immune response mediated by circulating immunoglobulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 22" id="KW-0228">DNA excision</keyword>
    <keyword evidence="17 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 22" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 22" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="12 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="25">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="24">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="578"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004652.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="763" mass="85417" checksum="B633803E38557E24" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZ79</accession>
    <name>A0A096MZ79_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tissue alpha-L-fucosidase</fullName>
            <ecNumber evidence="7">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alpha-L-fucosidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Alpha-L-fucoside fucohydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FUCA1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose</text>
            <dbReference type="Rhea" id="RHEA:49308"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:91119"/>
            <dbReference type="ChEBI" id="CHEBI:91121"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:49309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose</text>
            <dbReference type="Rhea" id="RHEA:48224"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17006"/>
            <dbReference type="ChEBI" id="CHEBI:28691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48225"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003891371.3">
        <property type="nucleotide sequence ID" value="XM_003891322.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZ79"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005274"/>
    <dbReference type="Ensembl" id="ENSPANT00000026600.3">
        <property type="protein sequence ID" value="ENSPANP00000005274.2"/>
        <property type="gene ID" value="ENSPANG00000006868.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019450"/>
    <dbReference type="KEGG" id="panu:101019450"/>
    <dbReference type="CTD" id="2517"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000035378"/>
    <dbReference type="HOGENOM" id="CLU_002934_1_1_1"/>
    <dbReference type="OMA" id="LPEHKWE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006868">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035578">
        <property type="term" value="C:azurophil granule lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000013">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018526">
        <property type="entry name" value="Glyco_hydro_29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF2">
        <property type="entry name" value="TISSUE ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00385">
        <property type="entry name" value="ALPHA_L_FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="17">
        <location>
            <begin position="134"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="18">
        <location>
            <begin position="481"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005274.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="569" mass="65225" checksum="01DCD6BEE08AA1F9" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N278</accession>
    <name>A0A096N278_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATG10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899939.2">
        <property type="nucleotide sequence ID" value="XM_003899890.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009206980.2">
        <property type="nucleotide sequence ID" value="XM_009208716.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009206982.2">
        <property type="nucleotide sequence ID" value="XM_009208718.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017815203.2">
        <property type="nucleotide sequence ID" value="XM_017959714.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017815204.2">
        <property type="nucleotide sequence ID" value="XM_017959715.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017815205.2">
        <property type="nucleotide sequence ID" value="XM_017959716.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N278"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006421"/>
    <dbReference type="Ensembl" id="ENSPANT00000028250.3">
        <property type="protein sequence ID" value="ENSPANP00000006421.2"/>
        <property type="gene ID" value="ENSPANG00000003860.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006873"/>
    <dbReference type="KEGG" id="panu:101006873"/>
    <dbReference type="CTD" id="83734"/>
    <dbReference type="eggNOG" id="KOG4741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000924"/>
    <dbReference type="HOGENOM" id="CLU_072332_4_0_1"/>
    <dbReference type="OMA" id="WKTSKDC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003860">
        <property type="expression patterns" value="Expressed in heart and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N278">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000002">
        <property type="entry name" value="Autophagy related 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006421.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="216" mass="24631" checksum="DF8CC5CD29A62476" modified="2022-05-25" version="2">MEEDEFIGEKTFQHYCAEFIKHSQQIGDSWEWRPSKDCSDGYMCKIHFQIKSGSVMSHPGASTHGQTCPPMEEAFELPSDDCEVIETAAASKVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEGVHECYKTRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMAPVLKNSRKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N6R5</accession>
    <accession>A0A096MLL9</accession>
    <name>A0A096N6R5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">FANCM-interacting histone fold protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017812592.1">
        <property type="nucleotide sequence ID" value="XM_017957103.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021790429.1">
        <property type="nucleotide sequence ID" value="XM_021934737.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N6R5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000448"/>
    <dbReference type="Ensembl" id="ENSPANT00000001298.3">
        <property type="protein sequence ID" value="ENSPANP00000000448.1"/>
        <property type="gene ID" value="ENSPANG00000005554.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000019830.3">
        <property type="protein sequence ID" value="ENSPANP00000008192.2"/>
        <property type="gene ID" value="ENSPANG00000034711.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101008189"/>
    <dbReference type="GeneID" id="101013291"/>
    <dbReference type="KEGG" id="panu:101008189"/>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7F7</accession>
    <name>A0A096N7F7_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">LAS1 like ribosome biosis factor</fullName>
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        <name evidence="2" type="primary">LAS1L</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
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                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
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                <person name="Quiroz J.Q."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
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                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N863</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays an important role in meiotic recombination and associated DNA double-strand break repair.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902877.1">
        <property type="nucleotide sequence ID" value="XM_003902828.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N863"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008788"/>
    <dbReference type="Ensembl" id="ENSPANT00000008019.3">
        <property type="protein sequence ID" value="ENSPANP00000008788.1"/>
        <property type="gene ID" value="ENSPANG00000009323.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001447"/>
    <dbReference type="KEGG" id="panu:101001447"/>
    <dbReference type="CTD" id="157777"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286951"/>
    <dbReference type="HOGENOM" id="CLU_032817_1_0_1"/>
    <dbReference type="OMA" id="SICLVPR"/>
    <dbReference type="OrthoDB" id="2015372at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009323">
        <property type="expression patterns" value="Expressed in testis and 55 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N863">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042140">
        <property type="term" value="P:late meiotic recombination nodule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001155">
        <property type="entry name" value="minichromosome maintenance domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058769">
        <property type="entry name" value="MCMDC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF75">
        <property type="entry name" value="MINICHROMOSOME MAINTENANCE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26063">
        <property type="entry name" value="MCMDC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCMDC2 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="MCM AAA-lid" evidence="7">
        <location>
            <begin position="540"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="681" mass="76139" checksum="063B1E8858D95036" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8F9</accession>
    <name>A0A096N8F9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-related transmembrane protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin domain-containing protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMX2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Homodimer; disulfide-linked. Occurs in both reduced and oxidized monomeric form. Oxidative conditions increase homodimerization. Interacts with CANX. Interacts with ATP2A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_017803859.1">
        <property type="nucleotide sequence ID" value="XM_017948370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8F9"/>
    <dbReference type="SMR" id="A0A096N8F9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008890"/>
    <dbReference type="Ensembl" id="ENSPANT00000009291.3">
        <property type="protein sequence ID" value="ENSPANP00000008890.2"/>
        <property type="gene ID" value="ENSPANG00000019136.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015532"/>
    <dbReference type="KEGG" id="panu:101015532"/>
    <dbReference type="CTD" id="51075"/>
    <dbReference type="eggNOG" id="KOG0914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003751"/>
    <dbReference type="HOGENOM" id="CLU_064868_0_0_1"/>
    <dbReference type="OMA" id="VIMIRTR"/>
    <dbReference type="OrthoDB" id="20229at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019136">
        <property type="expression patterns" value="Expressed in thyroid gland and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N8F9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02962">
        <property type="entry name" value="TMX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039101">
        <property type="entry name" value="TMX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037463">
        <property type="entry name" value="TMX2_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15853">
        <property type="entry name" value="THIOREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15853:SF0">
        <property type="entry name" value="THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="114"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008890.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="296" mass="34074" checksum="8C56BB8758DE1DC0" modified="2018-02-28" version="2">MAVLAPLIALVYSVPRLSRWLAQPYYLLSALLSAAFLLVRKLPPLCHGLPTQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANAILFFRLDIRMGLLYITLCIVFLMTCKPPLYMGPEYIKYFNDKTIDEELERDKRVTWIVEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPTLILFQGGKEVMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQRAKKLSKAGDNIPEEQPVAPTPTRVSDGESKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8N1</accession>
    <name>A0A096N8N1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Family with sequence similarity 241 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAM241A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM241 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899148.1">
        <property type="nucleotide sequence ID" value="XM_003899099.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8N1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008962"/>
    <dbReference type="Ensembl" id="ENSPANT00000010405.3">
        <property type="protein sequence ID" value="ENSPANP00000008962.1"/>
        <property type="gene ID" value="ENSPANG00000024713.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003841"/>
    <dbReference type="KEGG" id="panu:101003841"/>
    <dbReference type="CTD" id="132720"/>
    <dbReference type="eggNOG" id="ENOG502S3RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154340"/>
    <dbReference type="HOGENOM" id="CLU_160107_0_0_1"/>
    <dbReference type="OMA" id="MCSAGQL"/>
    <dbReference type="OrthoDB" id="9903800at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024713">
        <property type="expression patterns" value="Expressed in ascending colon and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027953">
        <property type="entry name" value="DUF4605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052502">
        <property type="entry name" value="FAM241_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33690">
        <property type="entry name" value="DUF4605 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33690:SF1">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 241 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15378">
        <property type="entry name" value="DUF4605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4605" evidence="8">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="132" mass="14724" checksum="F02805C159FDF67D" modified="2014-11-26" version="1">MCSAGELLRGGDGGERDEDGDALAEQAAAGTERDPEASPRRRGQRPKENEQDVEDSQNHTGEPVGDDYKKMGTLFGELNKNLINMGFTRMYFGERIVEPVIVIFFWVMLWFLGLQALGLVSVLCLVIIYVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8Q8</accession>
    <name>A0A096N8Q8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Reticulon 4 receptor like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RTN4RL1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <topology evidence="4">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Nogo receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N8Q8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008989"/>
    <dbReference type="Ensembl" id="ENSPANT00000023037.3">
        <property type="protein sequence ID" value="ENSPANP00000008989.3"/>
        <property type="gene ID" value="ENSPANG00000001706.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Bgee" id="ENSPANG00000001706">
        <property type="expression patterns" value="Expressed in amygdala and 11 other cell types or tissues"/>
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        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cell surface"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035374">
        <property type="term" value="F:chondroitin sulfate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0022038">
        <property type="term" value="P:corpus callosum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048681">
        <property type="term" value="P:negative regulation of axon regeneration"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Reticulon 4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF196">
        <property type="entry name" value="RETICULON 4 RECEPTOR LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286327" evidence="17">
        <location>
            <begin position="25"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="18">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008989.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="441" mass="49026" checksum="4B277936C5497464" modified="2022-05-25" version="3">MLRKGCCVELLLLLVAAGLPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNHIEYLQEDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRLGHRKSGKNCTSHRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N988</accession>
    <name>A0A096N988_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurexophilin and PC-esterase domain family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NXPE2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NXPE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N988"/>
    <dbReference type="Ensembl" id="ENSPANT00000020862.4">
        <property type="protein sequence ID" value="ENSPANP00000009193.1"/>
        <property type="gene ID" value="ENSPANG00000004639.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QW5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182866"/>
    <dbReference type="OMA" id="KIFIYRI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004639">
        <property type="expression patterns" value="Expressed in descending colon and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N988">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000920">
        <property type="entry name" value="NXPE family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF10">
        <property type="entry name" value="NXPE FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="3">
        <location>
            <begin position="336"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="559" mass="64688" checksum="A4F28D56E04C4897" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9R1</accession>
    <name>A0A096N9R1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUDT11</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A096N9R1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009391"/>
    <dbReference type="Ensembl" id="ENSPANT00000003228.3">
        <property type="protein sequence ID" value="ENSPANP00000009391.2"/>
        <property type="gene ID" value="ENSPANG00000043796.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160559"/>
    <dbReference type="HOGENOM" id="CLU_037162_1_0_1"/>
    <dbReference type="OMA" id="NTCNPTC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006680">
        <property type="expression patterns" value="Expressed in testis and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000002">
        <property type="entry name" value="diphosphoinositol polyphosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF35">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009391.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="163" mass="18428" checksum="1725FB2A756D4726" modified="2022-05-25" version="2">KCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVYVLTVTELLEDWEDSVSIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA99</accession>
    <name>A0A096NA99_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Malate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MDH2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="12"/>
    <dbReference type="RefSeq" id="XP_003895900.1">
        <property type="nucleotide sequence ID" value="XM_003895851.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NA99"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009603"/>
    <dbReference type="Ensembl" id="ENSPANT00000027209.3">
        <property type="protein sequence ID" value="ENSPANP00000009603.1"/>
        <property type="gene ID" value="ENSPANG00000017997.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002779"/>
    <dbReference type="KEGG" id="panu:101002779"/>
    <dbReference type="CTD" id="4191"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016686"/>
    <dbReference type="HOGENOM" id="CLU_047181_0_1_1"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017997">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NA99">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="31"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="35488" checksum="384C68ADE0500D51" modified="2014-11-26" version="1">MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAVVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLAAACAQHCPEAMICIIANPVNSTIPITAEVFKKHGVYNPSKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGQVSSFEEKMISDAIPELKASIKKGEDFVKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAL5</accession>
    <name>A0A096NAL5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G protein regulated inducer of neurite outgrowth 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GPRIN1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in neurite outgrowth.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900617.2">
        <property type="nucleotide sequence ID" value="XM_003900568.3"/>
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    <accession>A0A096NAM6</accession>
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        <name type="scientific">Papio anubis</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
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                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
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                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="17">Interacts with TNR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aggrecan/versican proteoglycan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009181912.2">
        <property type="nucleotide sequence ID" value="XM_009183648.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDK6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010953"/>
    <dbReference type="Ensembl" id="ENSPANT00000028473.3">
        <property type="protein sequence ID" value="ENSPANP00000010953.3"/>
        <property type="gene ID" value="ENSPANG00000024683.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009251"/>
    <dbReference type="CTD" id="63827"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157343"/>
    <dbReference type="HOGENOM" id="CLU_000303_0_0_1"/>
    <dbReference type="OMA" id="RWEAPQI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024683">
        <property type="expression patterns" value="Expressed in temporal lobe and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060074">
        <property type="term" value="P:synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03517">
        <property type="entry name" value="Link_domain_CSPGs_modules_1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03520">
        <property type="entry name" value="Link_domain_CSPGs_modules_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000011">
        <property type="entry name" value="Aggrecan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000698">
        <property type="entry name" value="brevican core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000003">
        <property type="entry name" value="Versican core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000003">
        <property type="entry name" value="Versican core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF41">
        <property type="entry name" value="BREVICAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 19" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="52"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="26">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="26">
        <location>
            <begin position="302"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="23">
        <location>
            <begin position="739"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="857"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="457"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="859"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006838"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010953.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="962" mass="104858" checksum="3AE98231706C186A" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NE45</accession>
    <name>A0A096NE45_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">E3 ubiquitin-protein ligase TRIM32</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">RING-type E3 ubiquitin transferase TRIM32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase TRIM5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">TRIM5alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Tripartite motif-containing protein 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Tripartite motif-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">TRIM32</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">It self-associates. Interacts with DTNBP1. Interacts with PIAS4/PIASY upon treatment with UVB and TNF-alpha. Interacts with AMBRA1; promoting activation of ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains. Interacts with TICAM1 and TAX1BP1; these interactions target TICAM1 to TAX1BP1-mediated selective autophagic degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003911363.1">
        <property type="nucleotide sequence ID" value="XM_003911314.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186449.1">
        <property type="nucleotide sequence ID" value="XM_009188185.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186450.1">
        <property type="nucleotide sequence ID" value="XM_009188186.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186451.1">
        <property type="nucleotide sequence ID" value="XM_009188187.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017804829.1">
        <property type="nucleotide sequence ID" value="XM_017949340.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021783493.1">
        <property type="nucleotide sequence ID" value="XM_021927801.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021783494.1">
        <property type="nucleotide sequence ID" value="XM_021927802.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021783495.1">
        <property type="nucleotide sequence ID" value="XM_021927803.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510725.1">
        <property type="nucleotide sequence ID" value="XM_031654865.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510726.1">
        <property type="nucleotide sequence ID" value="XM_031654866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NE45"/>
    <dbReference type="SMR" id="A0A096NE45"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011153"/>
    <dbReference type="Ensembl" id="ENSPANT00000025231.3">
        <property type="protein sequence ID" value="ENSPANP00000011153.1"/>
        <property type="gene ID" value="ENSPANG00000021111.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010674"/>
    <dbReference type="KEGG" id="panu:101010674"/>
    <dbReference type="CTD" id="22954"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160949"/>
    <dbReference type="HOGENOM" id="CLU_423860_0_0_1"/>
    <dbReference type="OMA" id="LPTMFQL"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021111">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005863">
        <property type="term" value="C:striated muscle myosin thick filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007014">
        <property type="term" value="P:actin ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061824">
        <property type="term" value="P:cytosolic ciliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048147">
        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902230">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034144">
        <property type="term" value="P:negative regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032897">
        <property type="term" value="P:negative regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903886">
        <property type="term" value="P:positive regulation of chemokine (C-C motif) ligand 20 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903883">
        <property type="term" value="P:positive regulation of interleukin-17-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051155">
        <property type="term" value="P:positive regulation of striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903265">
        <property type="term" value="P:positive regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905161">
        <property type="term" value="P:protein localization to phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044790">
        <property type="term" value="P:suppression of viral release by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19806">
        <property type="entry name" value="Bbox1_TRIM32_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14961">
        <property type="entry name" value="NHL_TRIM32_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd16587">
        <property type="entry name" value="RING-HC_TRIM32_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000034">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000039">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000314">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047051">
        <property type="entry name" value="TRIM32_Bbox1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25464:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25464">
        <property type="entry name" value="TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="ZF_BBOX"/>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="18" id="KW-0072">Autophagy</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 27" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="29">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="30">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="28">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="28">
        <location>
            <begin position="415"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="28">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="28">
        <location>
            <begin position="562"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="28">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00066261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00073068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00075992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00076816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="653" mass="72019" checksum="A4782A456FBAD67C" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFA5</accession>
    <name>A0A096NFA5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCAAT/enhancer-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CEBPD</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902767.2">
        <property type="nucleotide sequence ID" value="XM_003902718.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NFA5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011598"/>
    <dbReference type="Ensembl" id="ENSPANT00000002676.3">
        <property type="protein sequence ID" value="ENSPANP00000011598.3"/>
        <property type="gene ID" value="ENSPANG00000024953.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998981"/>
    <dbReference type="KEGG" id="panu:100998981"/>
    <dbReference type="CTD" id="1052"/>
    <dbReference type="eggNOG" id="KOG3119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163032"/>
    <dbReference type="HOGENOM" id="CLU_043327_2_1_1"/>
    <dbReference type="OMA" id="RRNMEMQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024953">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14714">
        <property type="entry name" value="bZIP_CEBPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000028">
        <property type="entry name" value="CCAAT/enhancer-binding protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016468">
        <property type="entry name" value="C/EBP_chordates"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF3">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005879">
        <property type="entry name" value="CCAAT/enhancer-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0010">Activator</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="13">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011598.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="269" mass="28347" checksum="A004BE14AC1B5529" modified="2022-05-25" version="3">MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAPAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRPLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPGPTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHH8</accession>
    <name>A0A096NHH8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tapasin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TAP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TAPBP</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer with PDIA3; disulfide-linked. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP. Interacts with HLA-G-B2M complex; this interaction is required for loading of high affinity peptides. On its own or as part of MHC class I peptide loading complex, interacts with ligand-free MR1 or MR1-B2M complex, providing for stable MR1 pools ready for metabolite antigen processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NHH8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012426"/>
    <dbReference type="Ensembl" id="ENSPANT00000012386.3">
        <property type="protein sequence ID" value="ENSPANP00000012426.2"/>
        <property type="gene ID" value="ENSPANG00000022348.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159200"/>
    <dbReference type="HOGENOM" id="CLU_043155_0_0_1"/>
    <dbReference type="OMA" id="YMPPTLE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022348">
        <property type="expression patterns" value="Expressed in thymus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NHH8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061779">
        <property type="term" value="C:Tapasin-ERp57 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062061">
        <property type="term" value="F:TAP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046978">
        <property type="term" value="F:TAP1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046979">
        <property type="term" value="F:TAP2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019885">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002479">
        <property type="term" value="P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002398">
        <property type="term" value="P:MHC class Ib protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002502">
        <property type="term" value="P:peptide antigen assembly with MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061635">
        <property type="term" value="P:regulation of protein complex stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000924">
        <property type="entry name" value="TAP binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001043">
        <property type="entry name" value="TAP binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001044">
        <property type="entry name" value="TAP binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008056">
        <property type="entry name" value="Tapasin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01669">
        <property type="entry name" value="TAPASIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014125927" description="Tapasin" evidence="15">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="292"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012426.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="503" mass="54142" checksum="A9F4D8AFACD5DB23" modified="2018-02-28" version="2">MKSLSLLLAVALGLATAVSAGPAVIECWFVEDTSGKGLAKRPGALLLRQGQGEPPPRPDLDPELYLNVHDPAGFLQAAFRRYPRDAPAPHCEMSRFVPLPASANWASGLTPARNCPRALDGAWLMVSMSSPVLSLSSLLRRQPEPQQEPVLITMATVVLTVLTHTPAPRVRLGQDALLDLSFAYMPPTSEAASSLAAGPPPFGLEWRRQHLGKGHLLLAATPGLNGQMPAAQEGAVAFAAWDDDEPWGPWTGNGTFWLPRVQPFQEGTYLATIHLPYLQGQVTLELAVYKPPKVSLMPATLAWAAPGEAPPELLCLVSHFYPPGGLEVEWELRGGPGGRSQKAEGQRWLSALRHHSDGSVSLSGHLQPPPVTTEQHGARYACRIHHPSLPASGRSAEVTLEVAGLSGPSLEDSIGLFLSAFFLLGLFKALGWAAVYLSTCKDSKKVHCSTSLYLSLVTLSPHPISKPMEGGCWCGRQNLGLEFTLIWVKTWHYILTVGLFVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NKX1</accession>
    <name>A0A096NKX1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TraB domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRABD</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017800924.3">
        <property type="nucleotide sequence ID" value="XM_017945435.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NKX1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013628"/>
    <dbReference type="Ensembl" id="ENSPANT00000012940.3">
        <property type="protein sequence ID" value="ENSPANP00000013628.3"/>
        <property type="gene ID" value="ENSPANG00000016596.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998430"/>
    <dbReference type="CTD" id="80305"/>
    <dbReference type="eggNOG" id="KOG2860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009067"/>
    <dbReference type="HOGENOM" id="CLU_034593_0_1_1"/>
    <dbReference type="OMA" id="MEKMMTT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016596">
        <property type="expression patterns" value="Expressed in pancreas and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160204">
        <property type="term" value="F:mitochondrion-mitochondrion outer membrane tether activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013628.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="392" mass="44031" checksum="2213CEAF5A29AB23" modified="2022-05-25" version="3">MPLLRLPTCARSHCPAMDGEEQQPPHEANVEPVVSSEASEPVPRVLSGDPQNLSDVDAFNLLLEMKLKRRRQQPNLPRTVTQLVAEDGSRVYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLKMDESTLLREAQELSLEKLQQAVRQNGLMSGLMQMLLLKVSAHITEQLGMAPGGEFREAFKEASKVPFCKFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLCFLSDPISKDDVERCKQKDLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARRLELPRASDAEPRKCVPSVVVGVVGMGHVPGIEKNWSTDLNIQEIMTVPPPSVSGRVSRLAVKAAFFGLLGYSLYWMGRRTASLVLSLPAAQYCLQRVTEARHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLH2</accession>
    <name>A0A096NLH2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein rogdi homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ROGDI</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rogdi family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NLH2"/>
    <dbReference type="Ensembl" id="ENSPANT00000024433.3">
        <property type="protein sequence ID" value="ENSPANP00000013830.2"/>
        <property type="gene ID" value="ENSPANG00000010497.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007164"/>
    <dbReference type="HOGENOM" id="CLU_062094_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010497">
        <property type="expression patterns" value="Expressed in amygdala and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLH2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013830.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="523" mass="57434" checksum="317940E30FCEE10A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NM46</accession>
    <name>A0A096NM46_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Unconventional myosin-Vc</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000014055"/>
    <dbReference type="Ensembl" id="ENSPANT00000025507.3">
        <property type="protein sequence ID" value="ENSPANP00000014055.3"/>
        <property type="gene ID" value="ENSPANG00000017451.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157971"/>
    <dbReference type="HOGENOM" id="CLU_000192_9_1_1"/>
    <dbReference type="OMA" id="YLGMFEF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017451">
        <property type="expression patterns" value="Expressed in pancreas and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NM46">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030050">
        <property type="term" value="P:vesicle transport along actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000016">
        <property type="entry name" value="Myosin VB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000089">
        <property type="entry name" value="Myosin VC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000005">
        <property type="entry name" value="unconventional myosin-Vc"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
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    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF313">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IQ"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="15">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="67"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="13">
        <location>
            <begin position="1421"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="884"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1253"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014055.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1606" mass="187109" checksum="154C1C5E10B8A5FD" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMR1</accession>
    <name>A0A096NMR1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CLK3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003901250.1">
        <property type="nucleotide sequence ID" value="XM_003901201.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NMR1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014270"/>
    <dbReference type="Ensembl" id="ENSPANT00000022859.3">
        <property type="protein sequence ID" value="ENSPANP00000014270.1"/>
        <property type="gene ID" value="ENSPANG00000015996.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999940"/>
    <dbReference type="KEGG" id="panu:100999940"/>
    <dbReference type="CTD" id="1198"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160359"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_16_1"/>
    <dbReference type="OMA" id="IYAVCLM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015996">
        <property type="expression patterns" value="Expressed in bone marrow and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14214">
        <property type="entry name" value="PKc_CLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000145">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000061">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF10">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE CLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="304"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="175"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="638" mass="73429" checksum="40C309A3931DF243" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NN66</accession>
    <name>A0A096NN66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Retinaldehyde-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cellular retinaldehyde-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RLBP1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DEGS1; the interaction increases synthesis of chromophore-precursors by DEGS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009209163.1">
        <property type="nucleotide sequence ID" value="XM_009210899.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017816407.1">
        <property type="nucleotide sequence ID" value="XM_017960918.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017816409.1">
        <property type="nucleotide sequence ID" value="XM_017960920.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031524229.1">
        <property type="nucleotide sequence ID" value="XM_031668369.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031524230.1">
        <property type="nucleotide sequence ID" value="XM_031668370.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031524231.1">
        <property type="nucleotide sequence ID" value="XM_031668371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NN66"/>
    <dbReference type="Ensembl" id="ENSPANT00000019781.3">
        <property type="protein sequence ID" value="ENSPANP00000014426.1"/>
        <property type="gene ID" value="ENSPANG00000011182.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019645"/>
    <dbReference type="KEGG" id="panu:101019645"/>
    <dbReference type="CTD" id="6017"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160026"/>
    <dbReference type="HOGENOM" id="CLU_046597_4_0_1"/>
    <dbReference type="OMA" id="IETCTLI"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011182">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NN66">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005502">
        <property type="term" value="F:11-cis retinal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019841">
        <property type="term" value="F:retinol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retinaldehyde binding protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.525.10:FF:000015">
        <property type="entry name" value="retinaldehyde-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF200">
        <property type="entry name" value="RETINALDEHYDE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0844">Vision</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="13">
        <location>
            <begin position="136"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        <source>
            <dbReference type="ARBA" id="ARBA00059298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="317" mass="36548" checksum="047D7675084E7D87" modified="2014-11-26" version="1">MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETREEAVRELQEMVQAQAASGEELAVAVAERMQEKDSGFFLRFIRARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVRCTIEAGYPGVLSSRDKYGRVVMLFNIENWQSQEITFDEILQAYCFILEKLLENEETQINGFCIIENFKGFTMQQAASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGEDLSGFYQEIDENILPSDFGGTLPKYDGKAVAEQLFGPRAQAENTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNJ7</accession>
    <name>A0A096NNJ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RTF2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with DDI2; probably also interacts with DDI1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904632.1">
        <property type="nucleotide sequence ID" value="XM_003904583.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNJ7"/>
    <dbReference type="Ensembl" id="ENSPANT00000025503.3">
        <property type="protein sequence ID" value="ENSPANP00000014557.1"/>
        <property type="gene ID" value="ENSPANG00000018566.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022001"/>
    <dbReference type="KEGG" id="panu:101022001"/>
    <dbReference type="CTD" id="51507"/>
    <dbReference type="eggNOG" id="KOG3113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010923"/>
    <dbReference type="HOGENOM" id="CLU_048955_1_0_1"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018566">
        <property type="expression patterns" value="Expressed in pineal body and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NNJ7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="305" mass="33739" checksum="2FE073611A295293" modified="2014-11-26" version="1">MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTKEDVDVLKARMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEETSLDSREKKNLAPKSTATNESSSGKAGKPLCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NRT1</accession>
    <name>A0A096NRT1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNL-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DNLZ</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003911135.1">
        <property type="nucleotide sequence ID" value="XM_003911086.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NRT1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015751"/>
    <dbReference type="Ensembl" id="ENSPANT00000028628.3">
        <property type="protein sequence ID" value="ENSPANP00000015751.2"/>
        <property type="gene ID" value="ENSPANG00000026117.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998001"/>
    <dbReference type="KEGG" id="panu:100998001"/>
    <dbReference type="CTD" id="728489"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008220"/>
    <dbReference type="HOGENOM" id="CLU_093902_5_0_1"/>
    <dbReference type="OMA" id="HPGKTEP"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026117">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NRT1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015751.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="178" mass="19149" checksum="54BAE6E3050629ED" modified="2018-02-28" version="2">MLRAALGGAPRLLSRVQPRGPCLRRLWGRGARPEVAGRRRAWAWGWRRSSSEPGPGPAAALGRVEAAHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPGCQNHHIIADNLGWFSDLNGKRNIEEILAARGEQVHRVVGEGALEFVLEAAGTPTSTAAPEAGEDEGPPGRGRTEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NS47</accession>
    <name>A0A096NS47_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch-like protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KLHL22</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1. Interacts with DEPDC5 (via DEP domain); the interaction depends on amino acid availability. Interacts with YWHAE; required for the nuclear localization of KLHL22 upon amino acid starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031656485.1"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000015867"/>
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        <property type="protein sequence ID" value="ENSPANP00000015867.3"/>
        <property type="gene ID" value="ENSPANG00000012339.4"/>
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    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Chromosome 16"/>
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    <dbReference type="Bgee" id="ENSPANG00000012339">
        <property type="expression patterns" value="Expressed in amygdala and 66 other cell types or tissues"/>
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        <property type="term" value="C:centrosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Kelch-like family member 22"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
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    <name>A0A096NTJ6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aly/REF export factor</fullName>
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        <name evidence="9" type="primary">ALYREF</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Nucleus</location>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Abraham K.A."/>
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                <person name="Forbes L.F."/>
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                <person name="Garcia-Iii R.G."/>
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                <person name="Gubbala S.G."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
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    </dbReference>
    <dbReference type="CDD" id="cd18467">
        <property type="entry name" value="BACK_KLHL28_BTBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18257">
        <property type="entry name" value="BTB_POZ_KLHL28_BTBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016784.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="585" mass="66008" checksum="57EB99B05C58D359" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NW70</accession>
    <name>A0A096NW70_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Par-6 family cell polarity regulator gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PARD6G</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003914574.1">
        <property type="nucleotide sequence ID" value="XM_003914525.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009191231.1">
        <property type="nucleotide sequence ID" value="XM_009192967.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NW70"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017295"/>
    <dbReference type="Ensembl" id="ENSPANT00000000606.4">
        <property type="protein sequence ID" value="ENSPANP00000017295.1"/>
        <property type="gene ID" value="ENSPANG00000004652.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101003483"/>
    <dbReference type="KEGG" id="panu:101003483"/>
    <dbReference type="CTD" id="84552"/>
    <dbReference type="eggNOG" id="KOG3606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183211"/>
    <dbReference type="HOGENOM" id="CLU_040653_2_0_1"/>
    <dbReference type="OMA" id="TEQSFDK"/>
    <dbReference type="OrthoDB" id="5868434at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004652">
        <property type="expression patterns" value="Expressed in cornea and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NW70">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06403">
        <property type="entry name" value="PB1_Par6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000031">
        <property type="entry name" value="Partitioning defective 6 homolog alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000030">
        <property type="entry name" value="Partitioning defective 6 homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034868">
        <property type="entry name" value="PB1_Par6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF3">
        <property type="entry name" value="PARTITIONING DEFECTIVE 6 HOMOLOG GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PB1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="376" mass="40823" checksum="7D82B916DA16311B" modified="2014-11-26" version="1">MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGLVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPTQAPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NW84</accession>
    <name>A0A096NW84_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Trifunctional enzyme subunit beta, mitochondrial</fullName>
            <ecNumber evidence="17">2.3.1.155</ecNumber>
            <ecNumber evidence="18">2.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">TP-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">HADHB</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN. Interacts with RSAD2/viperin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 30">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="17"/>
    <dbReference type="EC" id="2.3.1.16" evidence="18"/>
    <dbReference type="RefSeq" id="XP_021780365.1">
        <property type="nucleotide sequence ID" value="XM_021924673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NW84"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017309"/>
    <dbReference type="Ensembl" id="ENSPANT00000013034.3">
        <property type="protein sequence ID" value="ENSPANP00000017309.2"/>
        <property type="gene ID" value="ENSPANG00000018040.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015521"/>
    <dbReference type="CTD" id="3032"/>
    <dbReference type="eggNOG" id="KOG1392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234626"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018040">
        <property type="expression patterns" value="Expressed in heart and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NW84">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000020">
        <property type="entry name" value="Putative trifunctional enzyme subunit beta mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF153">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16 30" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 30" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="31">
        <location>
            <begin position="55"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="32">
        <location>
            <begin position="332"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017309.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="471" mass="51031" checksum="E53BD8234A8CE045" modified="2022-05-25" version="2">MTTILTYPFKKLPTTSKWALRFAIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDIPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRLNFLAPELPAVAEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFRVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQVRERGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0T5</accession>
    <name>A0A096P0T5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 9 open reading frame 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C9orf43</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096P0T5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018960"/>
    <dbReference type="Ensembl" id="ENSPANT00000027615.3">
        <property type="protein sequence ID" value="ENSPANP00000018960.2"/>
        <property type="gene ID" value="ENSPANG00000025782.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101026997"/>
    <dbReference type="eggNOG" id="ENOG502SUB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013600"/>
    <dbReference type="HOGENOM" id="CLU_604045_0_0_1"/>
    <dbReference type="OMA" id="CPEMKIQ"/>
    <dbReference type="OrthoDB" id="10033658at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025782">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029134">
        <property type="entry name" value="DUF4647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36130">
        <property type="entry name" value="RIKEN CDNA 4933430I17 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36130:SF1">
        <property type="entry name" value="RIKEN CDNA 4933430I17 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15504">
        <property type="entry name" value="DUF4647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018960.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="464" mass="53122" checksum="0DEF48139DF8CEB6" modified="2018-02-28" version="2">MDLPDESQWDETTCGFAVCQHPQCWATVRRIERGHPRILGSTCKTPLDAEDKLPVLTVVNISDSCFAPRHLPECTVTKARSLLSRSSKFYSKFNGRPPKGLPDKSLINCTNRLPKLPVLNLNETQLPCPEDVRNMVVLWIPEETEIHGSQHGKKKRKNLTMKSKSFLGLSGNQSAETRVGTPGMTVPPPTPVQLSKQFSSDFLPLWAQSEALPQDLLKELLPDRKQTMPCLEMKIKLAMMKKNLPLERNRPDSAISSKMFLSIHRLTLERPALRYPERLKKLHNLKTEGYRKQQQWQQQQQQRKVKTPIKKQEAKKKAKSDPGSQSTSHKHPVTTVHDPLYGYRTLPGQNSDMKQQQQMEKGTTSKQDSTERPKMDYCDHVDFHHNVKSPELYETEPTNKDISAPVEAVLEAQAARQKKISFNFSEIMVRTGWNSELKLLRILQETDDEDEENQYSEAEKPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P174</accession>
    <name>A0A096P174_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Talin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TLN1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003911573.2">
        <property type="nucleotide sequence ID" value="XM_003911524.5"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000026700.3">
        <property type="protein sequence ID" value="ENSPANP00000019099.2"/>
        <property type="gene ID" value="ENSPANG00000025430.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018767"/>
    <dbReference type="KEGG" id="panu:101018767"/>
    <dbReference type="CTD" id="7094"/>
    <dbReference type="eggNOG" id="KOG4261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157006"/>
    <dbReference type="HOGENOM" id="CLU_000364_1_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
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        <property type="entry name" value="B41"/>
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        <property type="entry name" value="A middle domain of Talin 1"/>
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        <property type="entry name" value="alpha-catenin/vinculin-like"/>
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        <property type="entry name" value="PH domain-like"/>
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        <property type="entry name" value="Second domain of FERM"/>
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        <property type="entry name" value="Ubiquitin-like"/>
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        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="86"/>
            <end position="403"/>
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        <location>
            <begin position="2293"/>
            <end position="2533"/>
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        <location>
            <begin position="1024"/>
            <end position="1077"/>
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    <feature type="coiled-coil region" evidence="10">
        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019099.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2541" mass="269770" checksum="66348F83C7E66B32" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1H4</accession>
    <name>A0A096P1H4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SH3 domain containing GRB2 like 2, endophilin A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SH3GL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017805328.1">
        <property type="nucleotide sequence ID" value="XM_017949839.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P1H4"/>
    <dbReference type="SMR" id="A0A096P1H4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019199"/>
    <dbReference type="Ensembl" id="ENSPANT00000025797.3">
        <property type="protein sequence ID" value="ENSPANP00000019199.3"/>
        <property type="gene ID" value="ENSPANG00000025232.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005109"/>
    <dbReference type="CTD" id="6456"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160529"/>
    <dbReference type="HOGENOM" id="CLU_047887_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025232">
        <property type="expression patterns" value="Expressed in cerebellum and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P1H4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07613">
        <property type="entry name" value="BAR_Endophilin_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000053">
        <property type="entry name" value="endophilin-A1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000021">
        <property type="entry name" value="Endophilin-A2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF50">
        <property type="entry name" value="ENDOPHILIN-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="15">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019199.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="352" mass="39946" checksum="62C395888C4A06EA" modified="2022-05-25" version="3">MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASAQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P393</accession>
    <accession>A0A2I3MHP9</accession>
    <name>A0A096P393_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,5-anhydro-D-fructose reductase</fullName>
            <ecNumber evidence="5">1.1.1.263</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldo-keto reductase family 1 member C-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Aldo-keto reductase family 1 member E2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16070"/>
            <dbReference type="ChEBI" id="CHEBI:16715"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.263"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.263" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003903379.1">
        <property type="nucleotide sequence ID" value="XM_003903330.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508414.1">
        <property type="nucleotide sequence ID" value="XM_031652554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P393"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019818"/>
    <dbReference type="Ensembl" id="ENSPANT00000021929.3">
        <property type="protein sequence ID" value="ENSPANP00000019818.1"/>
        <property type="gene ID" value="ENSPANG00000023517.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000036348.2">
        <property type="protein sequence ID" value="ENSPANP00000035239.2"/>
        <property type="gene ID" value="ENSPANG00000051363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101021644"/>
    <dbReference type="GeneID" id="116268518"/>
    <dbReference type="KEGG" id="panu:101021644"/>
    <dbReference type="CTD" id="83592"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153272"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="AWKAMEG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023517">
        <property type="expression patterns" value="Expressed in testis and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P393">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050571">
        <property type="term" value="F:1,5-anhydro-D-fructose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19110">
        <property type="entry name" value="AKR_AKR1E1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000030">
        <property type="entry name" value="Aldo-keto reductase family 1 member E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044484">
        <property type="entry name" value="AKR1E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="320" mass="36370" checksum="56171466E4A8717F" modified="2014-11-26" version="1">MGDIPAVGLSCWKASPGKVTEAVKVAIDAGYRHFNCAYFYHNEKEVGAGIRCKIKEGAVRREDLFIASKLWCTCHKKSLVKTACRRSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPGVHDLPLDESDMVIPGDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPVTNQIECHPYLTQKNLISFCQSRGVSVTAYRPLGGSCEGVDLIDDPVIQRIAKEHSKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLDRNLRLATFPITKNHKDYPFHIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P633</accession>
    <name>A0A096P633_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCDC43</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P633"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020808"/>
    <dbReference type="Ensembl" id="ENSPANT00000014295.3">
        <property type="protein sequence ID" value="ENSPANP00000020808.3"/>
        <property type="gene ID" value="ENSPANG00000021312.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RYDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015009"/>
    <dbReference type="HOGENOM" id="CLU_079381_2_0_1"/>
    <dbReference type="OMA" id="KFLFRNT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021312">
        <property type="expression patterns" value="Expressed in gastrocnemius and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020808.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="229" mass="25678" checksum="179AD37D472B573B" modified="2022-05-25" version="3">MAAPSEVAAVAPGEGDGGGGGGGFGSWLDGRLEALGVDRAVYGAYILGVLREEEEEEKLDALQGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQAIATLIEKQAQIVVKPRMVSEEEKQRKAALLAQYADVTDEEESLTEADEKDDSGATTMNIGSDKLLFRNTNVEDVLNARKLERDSLRDESQRKKEQDKLQRERDKLAKQERKEKEKKRTQRGERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P6G1</accession>
    <name>A0A096P6G1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BORCS7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009213530.2">
        <property type="nucleotide sequence ID" value="XM_009215266.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P6G1"/>
    <dbReference type="SMR" id="A0A096P6G1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020936"/>
    <dbReference type="Ensembl" id="ENSPANT00000012234.3">
        <property type="protein sequence ID" value="ENSPANP00000020936.2"/>
        <property type="gene ID" value="ENSPANG00000020979.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103887700"/>
    <dbReference type="KEGG" id="panu:103887700"/>
    <dbReference type="CTD" id="119032"/>
    <dbReference type="eggNOG" id="ENOG502S2QS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015849"/>
    <dbReference type="HOGENOM" id="CLU_150749_1_0_1"/>
    <dbReference type="OMA" id="HAAKNFA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020979">
        <property type="expression patterns" value="Expressed in heart and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050905">
        <property type="term" value="P:neuromuscular process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046898">
        <property type="term" value="P:response to cycloheximide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090659">
        <property type="term" value="P:walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397:SF3">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020936.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="106" mass="11681" checksum="F35C271461879F7E" modified="2018-02-28" version="2">MMATGTPDSQARFGQSVKGLLTEKVTTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSDLQDQLNHLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MU01</accession>
    <name>A0A0A0MU01_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 628</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF628</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with TAF4B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021787149.1">
        <property type="nucleotide sequence ID" value="XM_021931457.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MU01"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000392"/>
    <dbReference type="Ensembl" id="ENSPANT00000020106.3">
        <property type="protein sequence ID" value="ENSPANP00000000392.3"/>
        <property type="gene ID" value="ENSPANG00000012246.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023270"/>
    <dbReference type="KEGG" id="panu:101023270"/>
    <dbReference type="CTD" id="89887"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144307"/>
    <dbReference type="HOGENOM" id="CLU_002678_15_0_1"/>
    <dbReference type="OMA" id="ACAERPY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012246">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000111">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000968">
        <property type="entry name" value="zinc finger protein 628"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001088">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001642">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001824">
        <property type="entry name" value="zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001866">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF375">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
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                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May play a role in vesicular transport during the biogenesis of melanosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit transport protein particle (TRAPP) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWX8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010643"/>
    <dbReference type="Ensembl" id="ENSPANT00000001784.3">
        <property type="protein sequence ID" value="ENSPANP00000010643.2"/>
        <property type="gene ID" value="ENSPANG00000008090.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012948"/>
    <dbReference type="HOGENOM" id="CLU_076409_3_1_1"/>
    <dbReference type="OMA" id="PACELHY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008090">
        <property type="expression patterns" value="Expressed in ascending colon and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MWX8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000009">
        <property type="entry name" value="Trafficking protein particle complex subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF2">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010643.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="173" mass="18847" checksum="5B5421E8A9D17184" modified="2018-02-28" version="2">MADTVLFEFLHTEMVAELWAHDPDPGPGVSAGSRGEEVGATTGQKMSLSVLEGMGFRVGQALGERLPRETLAFREELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPLLLPMASGLQYLEEAPKFLAFTCGLLRGALCTLGIESVVTASVAALPVCKFQVVIPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MX10</accession>
    <name>A0A0A0MX10_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transducin-like enhancer protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TLE6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimers. Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6. Within the complex, interacts with NLRP5, KHDC3 and OOEP. The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments. As part of the SCMC interacts with the SCMC-associated protein ZBED3. As part of the SCMC interacts with the SCMC-associated protein NLRP4F. As part of the SCMC interacts with the SCMC-associated protein CFL1/Cofilin-1. Interacts with FOXG1/BF-1; the interaction inhibits TLE1 interaction with FOXG1/BF-1. Interacts with NFATC1. Interacts with PAX6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MX10"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010786"/>
    <dbReference type="Ensembl" id="ENSPANT00000015533.3">
        <property type="protein sequence ID" value="ENSPANP00000010786.3"/>
        <property type="gene ID" value="ENSPANG00000014013.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234519"/>
    <dbReference type="HOGENOM" id="CLU_007612_1_0_1"/>
    <dbReference type="OMA" id="KEELPCA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014013">
        <property type="expression patterns" value="Expressed in pancreas and 30 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140095">
        <property type="term" value="C:cytoplasmic lattice"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106333">
        <property type="term" value="C:subcortical maternal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140094">
        <property type="term" value="F:structural constituent of cytoplasmic lattice"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060136">
        <property type="term" value="P:embryonic process involved in female pregnancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140089">
        <property type="term" value="P:protein storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000546">
        <property type="entry name" value="TLE family member 6, subcortical maternal complex member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF2">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010786.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="570" mass="63538" checksum="0F94E345A70FFE1E" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LCX8</accession>
    <name>A0A2I3LCX8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox A13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HOXA13</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LCX8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000021294"/>
    <dbReference type="Ensembl" id="ENSPANT00000035082.2">
        <property type="protein sequence ID" value="ENSPANP00000021294.2"/>
        <property type="gene ID" value="ENSPANG00000030952.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162322"/>
    <dbReference type="OMA" id="CPKEQNQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030952">
        <property type="expression patterns" value="Expressed in prostate gland and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060442">
        <property type="term" value="P:branching involved in prostate gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060847">
        <property type="term" value="P:endothelial cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001886">
        <property type="term" value="P:endothelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030539">
        <property type="term" value="P:male genitalia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097152">
        <property type="term" value="P:mesenchymal cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140014">
        <property type="term" value="P:mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001055">
        <property type="term" value="P:positive regulation of mesenchymal cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003281">
        <property type="term" value="P:ventricular septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000130">
        <property type="entry name" value="Homeobox protein Hox-D12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051003">
        <property type="entry name" value="AP_axis_regulatory_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022067">
        <property type="entry name" value="HoxA13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45804:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45804">
        <property type="entry name" value="SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12284">
        <property type="entry name" value="HoxA13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="295"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021294.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="363" mass="37743" checksum="4DA8CE7E458032F0" modified="2022-05-25" version="2">MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAGGPPVAAAAAAAAAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPHLWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKKVINKLKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LIB5</accession>
    <name>A0A2I3LIB5_PAPAN</name>
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            <fullName evidence="3">Histidine rich calcium binding protein</fullName>
        </submittedName>
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        <name evidence="3" type="primary">HRC</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <property type="term" value="F:transmembrane transporter binding"/>
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        <property type="term" value="P:cell adhesion"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LK95</accession>
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            <fullName evidence="2">Mastermind like domain containing 1</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
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                <person name="Khan N.K."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
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                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
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                <person name="Munidasa M.M."/>
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                <person name="Nguyen L.N."/>
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                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
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                <person name="Usmani K.U."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    <dbReference type="Ensembl" id="ENSPANT00000046608.2">
        <property type="protein sequence ID" value="ENSPANP00000023848.2"/>
        <property type="gene ID" value="ENSPANG00000008461.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022572"/>
    <dbReference type="CTD" id="10046"/>
    <dbReference type="GeneTree" id="ENSGT00730000111366"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008461">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026131">
        <property type="entry name" value="MAMLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15275">
        <property type="entry name" value="CG1 PROTEIN/F18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15275:SF0">
        <property type="entry name" value="MASTERMIND-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023848.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="777" mass="83505" checksum="425ACB97F0FE9A8A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LPZ4</accession>
    <name>A0A2I3LPZ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor TFIIB cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LPZ4"/>
    <dbReference type="Ensembl" id="ENSPANT00000050506.2">
        <property type="protein sequence ID" value="ENSPANP00000025502.1"/>
        <property type="gene ID" value="ENSPANG00000021761.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010349"/>
    <dbReference type="OMA" id="ICAGEIC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021761">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LPZ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
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    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="11">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="188" mass="21090" checksum="AA01B6255584FE6A" modified="2018-02-28" version="1">MTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELENSPPSRREGRGRPESLPRAWPLHGKVPVPPIGGLSSGMAALDVAKEGASPCVPRRGWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LVI8</accession>
    <name>A0A2I3LVI8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FBXO27</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031515345.1">
        <property type="nucleotide sequence ID" value="XM_031659485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LVI8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000027475"/>
    <dbReference type="Ensembl" id="ENSPANT00000054470.2">
        <property type="protein sequence ID" value="ENSPANP00000027475.2"/>
        <property type="gene ID" value="ENSPANG00000032620.2"/>
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    <dbReference type="GeneID" id="101014302"/>
    <dbReference type="CTD" id="126433"/>
    <dbReference type="GeneTree" id="ENSGT00940000161841"/>
    <dbReference type="OMA" id="TCFASSY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
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    <dbReference type="Bgee" id="ENSPANG00000032620">
        <property type="expression patterns" value="Expressed in amygdala and 32 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.1280.50:FF:000002">
        <property type="entry name" value="F-box only protein 44"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
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    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
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    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="4">
        <location>
            <begin position="106"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027475.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="285" mass="32043" checksum="2AA924AA46581F0E" modified="2022-05-25" version="2">MGAWASRGRAARVPVPEPEPEPEEALDLSQLPPELLLVVLSHVPPRTLLGRCRQVCRGWRALVDGQALWLLILARDHSATGRALLHLARSCQSPARNARPCPLGRFCARRPIGRNLIRNPCGQEGLRKWMVQHGGDGWVVEENRTTVPGAPSQTCFVTSFSWCRKKQVLDLEEEGLWPELLDSGRIEICVSDWWGARHDSGCMYRLLVQLLDANQTVLDKFSAVPDPIPQWNNNACLHVTHVFSNIKMGVRFVSFEHWGQDTQFWAGHYGARVTNSSVIVRVHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M154</accession>
    <name>A0A2I3M154_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M154"/>
    <dbReference type="STRING" id="9555.ENSPANP00000029399"/>
    <dbReference type="Ensembl" id="ENSPANT00000019336.3">
        <property type="protein sequence ID" value="ENSPANP00000029399.2"/>
        <property type="gene ID" value="ENSPANG00000016901.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287035"/>
    <dbReference type="OMA" id="PSPRCEN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026082">
        <property type="expression patterns" value="Expressed in muscle tissue and 1 other cell type or tissue"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029399.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="166" mass="18172" checksum="92410F46D8AB0189" modified="2022-05-25" version="2">MSPWSLGGMQKTGLASDSQSGRHPTLLAPQFLEAGGQKKDIGYFDNPKADSRNITNSMTFLTKSSNHNFIVFLSKVQAIIIEYKGCDFLAILDPLDPDTLPNGRIWLFGFSSYFFQHNSFCMKSTSKRVGLQGCAQMGFLPPSSTKSTTLAHPASATGLSKRENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M4A2</accession>
    <name>A0A2I3M4A2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031506903.1">
        <property type="nucleotide sequence ID" value="XM_031651043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M4A2"/>
    <dbReference type="SMR" id="A0A2I3M4A2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000030513"/>
    <dbReference type="Ensembl" id="ENSPANT00000058030.2">
        <property type="protein sequence ID" value="ENSPANP00000030513.2"/>
        <property type="gene ID" value="ENSPANG00000008970.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004373"/>
    <dbReference type="KEGG" id="panu:101004373"/>
    <dbReference type="CTD" id="22818"/>
    <dbReference type="GeneTree" id="ENSGT00390000004405"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008970">
        <property type="expression patterns" value="Expressed in pyloric antrum and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M4A2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000008">
        <property type="entry name" value="Coatomer subunit zeta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF2">
        <property type="entry name" value="COATOMER SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030513.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="177" mass="20198" checksum="355530D032D3A049" modified="2022-05-25" version="2">MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M4H9</accession>
    <name>A0A2I3M4H9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003910610.3">
        <property type="nucleotide sequence ID" value="XM_003910561.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M4H9"/>
    <dbReference type="Ensembl" id="ENSPANT00000046524.2">
        <property type="protein sequence ID" value="ENSPANP00000030549.2"/>
        <property type="gene ID" value="ENSPANG00000032105.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101009373"/>
    <dbReference type="KEGG" id="panu:101009373"/>
    <dbReference type="CTD" id="105484334"/>
    <dbReference type="GeneTree" id="ENSGT00520000058823"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032105">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040429">
        <property type="entry name" value="C11orf97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38326">
        <property type="entry name" value="CHROMOSOME 11 OPEN READING FRAME 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38326:SF1">
        <property type="entry name" value="CHROMOSOME 11 OPEN READING FRAME 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030549.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="156" mass="17440" checksum="0BD7B36986875BC4" modified="2022-05-25" version="2">MATRDASRAGRPATELRRKQCPGLSEDSCGMTGEEAVVVTAMVAPEACREEEQPPPPAGLGCEAREEPGRGRVEHGQQWKKFLYCEPHKRIKEVLEEELYIKRDECHIKNPAAVALEGIWSIKRNLPVEGLKPGLPSRNSLLPQAKYYSRHGGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M4Z3</accession>
    <name>A0A2I3M4Z3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division cycle associated 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CDCA7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003907671.2">
        <property type="nucleotide sequence ID" value="XM_003907622.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M4Z3"/>
    <dbReference type="Ensembl" id="ENSPANT00000043806.2">
        <property type="protein sequence ID" value="ENSPANP00000030709.2"/>
        <property type="gene ID" value="ENSPANG00000024998.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998893"/>
    <dbReference type="CTD" id="83879"/>
    <dbReference type="GeneTree" id="ENSGT00940000155436"/>
    <dbReference type="OMA" id="DCWGIRG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024998">
        <property type="expression patterns" value="Expressed in thymus and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M4Z3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044729">
        <property type="term" value="F:hemi-methylated DNA-binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040221">
        <property type="entry name" value="CDCA7/CDA7L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169:SF2">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169">
        <property type="entry name" value="OS05G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="342"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030709.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="450" mass="51454" checksum="A6B15392821F3519" modified="2022-05-25" version="2">MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAESPQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRKTMDGYMNEDDLPRSRRSRSSMTLPHIIRPVEEITEEELENICSNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLDPNWRCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MD03</accession>
    <name>A0A2I3MD03_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger and BTB domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZBTB10</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021798149.2">
        <property type="nucleotide sequence ID" value="XM_021942457.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MD03"/>
    <dbReference type="Ensembl" id="ENSPANT00000035993.2">
        <property type="protein sequence ID" value="ENSPANP00000033490.2"/>
        <property type="gene ID" value="ENSPANG00000034587.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101011915"/>
    <dbReference type="KEGG" id="panu:101011915"/>
    <dbReference type="CTD" id="65986"/>
    <dbReference type="GeneTree" id="ENSGT00940000157988"/>
    <dbReference type="OMA" id="ESCDQTT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034587">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18201">
        <property type="entry name" value="BTB_POZ_ZBTB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000492">
        <property type="entry name" value="Zinc finger and BTB domain containing 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000045">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF24">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="364"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="812"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033490.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="871" mass="94930" checksum="1FDE8CAFBC9BCC3E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MDK2</accession>
    <name>A0A2I3MDK2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PDE4B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_003892061.2">
        <property type="nucleotide sequence ID" value="XM_003892012.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MDK2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033823"/>
    <dbReference type="Ensembl" id="ENSPANT00000047239.2">
        <property type="protein sequence ID" value="ENSPANP00000033823.2"/>
        <property type="gene ID" value="ENSPANG00000008973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006354"/>
    <dbReference type="KEGG" id="panu:101006354"/>
    <dbReference type="CTD" id="5142"/>
    <dbReference type="GeneTree" id="ENSGT00940000155190"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008973">
        <property type="expression patterns" value="Expressed in gastrocnemius and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MDK2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071872">
        <property type="term" value="P:cellular response to epinephrine stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
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        <location>
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    <sequence length="736" mass="83247" checksum="106E29B91CBF1C8C" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MDZ5</accession>
    <name>A0A2I3MDZ5_PAPAN</name>
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        <submittedName>
            <fullName evidence="11">Centromere protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CENPH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
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        <property type="nucleotide sequence ID" value="XM_003899760.5"/>
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        <property type="protein sequence ID" value="ENSPANP00000033810.2"/>
        <property type="gene ID" value="ENSPANG00000032466.2"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="Bgee" id="ENSPANG00000032466">
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    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CENP-H_C"/>
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        <property type="entry name" value="CENTROMERE PROTEIN H"/>
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        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="42"/>
            <end position="241"/>
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        <location>
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        <location>
            <begin position="75"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="25"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="247" mass="28293" checksum="49CE520D2BD6425C" modified="2022-05-25" version="2">MEEQPQMQATDEPADSGEEGGAGGPPQVAGAQAAPSEDRMTLLLRLRAQTKQQLLEYKSMIDANEEKTPEQIMQEKQIEAKIEDLENEIEEVKISFEIKKLALDRMRLSAALKKNLEKISTQSSVLMDNMKHLVELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKIDLDSMENSDGIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQLEKNVDMM</sequence>
</entry>
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    <accession>A0A2I3MJ01</accession>
    <name>A0A2I3MJ01_PAPAN</name>
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        <submittedName>
            <fullName evidence="13">ELKS/RAB6-interacting/CAST family member 1</fullName>
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        <name evidence="13" type="primary">ERC1</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
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    <dbReference type="GO" id="GO:0008385">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Tropomyosin"/>
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    </evidence>
    <sequence length="1120" mass="128415" checksum="A273526E599E6211" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MJ20</accession>
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        <submittedName>
            <fullName evidence="7">G protein subunit beta 2</fullName>
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        <name evidence="7" type="primary">GNB2</name>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
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                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
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                <person name="Garcia-Iii R.G."/>
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                <person name="Gubbala S.G."/>
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                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Kalu J.K."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003918941.1">
        <property type="nucleotide sequence ID" value="XM_003918892.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031521407.1">
        <property type="nucleotide sequence ID" value="XM_031665547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MJ20"/>
    <dbReference type="SMR" id="A0A2I3MJ20"/>
    <dbReference type="Ensembl" id="ENSPANT00000055011.2">
        <property type="protein sequence ID" value="ENSPANP00000035793.2"/>
        <property type="gene ID" value="ENSPANG00000018442.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017982"/>
    <dbReference type="KEGG" id="panu:101017982"/>
    <dbReference type="CTD" id="2783"/>
    <dbReference type="GeneTree" id="ENSGT01000000214413"/>
    <dbReference type="OMA" id="SCCRFLT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018442">
        <property type="expression patterns" value="Expressed in aorta and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035793.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="340" mass="37331" checksum="5D08FFA240ADEEE6" modified="2022-05-25" version="2">MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MMZ9</accession>
    <name>A0A2I3MMZ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">C-type lectin domain family 4 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CLEC4A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021777686.1">
        <property type="nucleotide sequence ID" value="XM_021921994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MMZ9"/>
    <dbReference type="Ensembl" id="ENSPANT00000039982.2">
        <property type="protein sequence ID" value="ENSPANP00000037055.1"/>
        <property type="gene ID" value="ENSPANG00000007775.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018000"/>
    <dbReference type="CTD" id="50856"/>
    <dbReference type="GeneTree" id="ENSGT00940000158835"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007775">
        <property type="expression patterns" value="Expressed in bone marrow and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MMZ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000024">
        <property type="entry name" value="C-type lectin domain family 4 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0465">Mannose-binding</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="17">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="204" mass="23731" checksum="B2A129C02A2015AF" modified="2018-02-28" version="1">MTSEITYAEVRFQNESKFSGIDSASSAASKERTAPHKSNTGFSKLLCASLMIFFLLLAISLFIAFFKTAWSCCPKNWKPFSSNCYFISTESASWQKSEKDCARMEAHLLVINTREEQDFIFQNLQEESAYFVGLSDPKGQRHWQWVDQTPYNESSTFWHPHEPSDPDERCVVLNFHKTPKRWGWNDIHCNVHQRSVCEMMKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MP21</accession>
    <name>A0A2I3MP21_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PNMA family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PNMA3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021788501.1">
        <property type="nucleotide sequence ID" value="XM_021932809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MP21"/>
    <dbReference type="STRING" id="9555.ENSPANP00000037482"/>
    <dbReference type="Ensembl" id="ENSPANT00000007166.3">
        <property type="protein sequence ID" value="ENSPANP00000037482.2"/>
        <property type="gene ID" value="ENSPANG00000008016.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004213"/>
    <dbReference type="KEGG" id="panu:101004213"/>
    <dbReference type="CTD" id="29944"/>
    <dbReference type="GeneTree" id="ENSGT01030000234522"/>
    <dbReference type="OMA" id="RGAQTNN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008016">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048271">
        <property type="entry name" value="PNMA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF22">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20846">
        <property type="entry name" value="PNMA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037482.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="463" mass="52375" checksum="E531A11BB712403C" modified="2022-05-25" version="2">MPLTLLQDWCRGEHLNTQRCMLILGIPEDCGEDEFEETLQEACRHLGRYRVIGRMFRREENAQAILLELAQDIDYALLPREIPGKGGPWEVIVKPRNSDGEFLDRLNRFLEEERRTVADMNRVLGSDTNCSAPRVTISPEFWTWAQTLGAAVQPLLEQMLYRELRVFSGNTISIPGALAFDAWLEHTTEMLQMWQVPEGEKRRRLMECLRGPALQVVSGLRASNASITVEECLAALQQVFGPVESHKIAQVKLCKAYQEAGEKVSSFVLRLEPLLQRAVENNVVSRRNVNQTRLKRVLSGATLPDKLRDKLKLMKQRRKPPGFLALVKLLREEEEWEATLGPDRESLEGLEVAPRPPARITGVGAVPLPASGNSFDVRPSQGYRRRRGRGQHRRGGVARAGSRGSRKRKRHTFCYSCGEDGHIRVQCINPSNLLLVKQKKQAAIESGNGNWAWDKSHPKSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MT70</accession>
    <name>A0A2I3MT70_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 17">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 17">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">IMPDH1</name>
        <name evidence="14" type="synonym">IMPDH</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 17">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 14 17">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000038968.1"/>
        <property type="gene ID" value="ENSPANG00000011996.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154156"/>
    <dbReference type="OMA" id="MGYCGAK"/>
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        <property type="reaction ID" value="UER00295"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="CBS_dom"/>
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        <property type="entry name" value="IMP_DH"/>
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        <property type="entry name" value="IMP_dehydrog"/>
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        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1"/>
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        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
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    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 14 17" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="199"/>
            <end position="258"/>
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        <location>
            <begin position="264"/>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
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    <feature type="active site" description="Thioimidate intermediate" evidence="14">
        <location>
            <position position="416"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="514"/>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="359"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="409"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="411"/>
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        <ligand>
            <name>K(+)</name>
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            <note>ligand shared between two tetrameric partners</note>
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    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="413"/>
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        <ligand>
            <name>K(+)</name>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="414"/>
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        <ligand>
            <name>IMP</name>
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    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="416"/>
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        <ligand>
            <name>K(+)</name>
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            <note>ligand shared between two tetrameric partners</note>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="449"/>
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        <ligand>
            <name>IMP</name>
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    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="472"/>
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        <ligand>
            <name>IMP</name>
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    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="496"/>
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        <ligand>
            <name>IMP</name>
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    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="526"/>
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        <ligand>
            <name>IMP</name>
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    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="581"/>
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        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00046101"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="599" mass="64385" checksum="73E65BE3D9ECFA3A" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUZ5</accession>
    <name>A0A2I3MUZ5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain containing 14A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MFSD14A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUZ5"/>
    <dbReference type="Ensembl" id="ENSPANT00000052585.2">
        <property type="protein sequence ID" value="ENSPANP00000039598.2"/>
        <property type="gene ID" value="ENSPANG00000020894.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157395"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020894">
        <property type="expression patterns" value="Expressed in caecum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MUZ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF77">
        <property type="entry name" value="HIPPOCAMPUS ABUNDANT TRANSCRIPT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039598.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="452" mass="48677" checksum="DA75D63DC3765390" modified="2022-05-25" version="2">MTQGKKKKRAANRSIMLAKKIIIKDGGTPQGIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFAIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPEHTNLSLRSSSWRKHCGSHSHPHSTQAPGEAKEPLLQDTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N387</accession>
    <accession>A0A2I3MY65</accession>
    <name>A0A2I3N387_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dematin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Dematin actin-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Erythrocyte membrane protein band 4.9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DMTN</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N387"/>
    <dbReference type="STRING" id="9555.ENSPANP00000040704"/>
    <dbReference type="Ensembl" id="ENSPANT00000042676.2">
        <property type="protein sequence ID" value="ENSPANP00000042474.2"/>
        <property type="gene ID" value="ENSPANG00000020182.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000051630.2">
        <property type="protein sequence ID" value="ENSPANP00000040704.2"/>
        <property type="gene ID" value="ENSPANG00000020182.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182850"/>
    <dbReference type="OMA" id="MLEHKIY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020182">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N387">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031253">
        <property type="term" value="C:cell projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031095">
        <property type="term" value="C:platelet dense tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014731">
        <property type="term" value="C:spectrin-associated cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <sequence length="405" mass="45603" checksum="0E3A562336650042" modified="2022-05-25" version="2">MERLQKQPLTSPGSVSPSRDSSVPGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRERSLSPKSTSPPPSPEVWADSRSPGIISQASAPRTTGTPRTSLPHFHHPETSRPDSNIYKKPPIYKQRESVGGSPQTKHLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRRRAEEEEEEEDDDSGEEMKALRERQREELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHQGTSKSSSLPAYGRTTLSRLQSTEFSPSGSETGSPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNKGRTKLPSGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N9B1</accession>
    <name>A0A2I3N9B1_PAPAN</name>
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        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKRD10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000035969.2"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR24201:SF12">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 10"/>
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        <property type="entry name" value="Ank"/>
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        <property type="entry name" value="ANK"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
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        <property type="entry name" value="ANK_REPEAT"/>
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            <begin position="124"/>
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        </source>
    </evidence>
    <sequence length="420" mass="44800" checksum="76AF351E45294682" modified="2022-05-25" version="2">MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLTSEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLEDSEAFGVKKARTEAQSLDSAVPLMNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTLLSGMESRNGQCLTGSNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCVASRPSWVEDIGDNLYYGHYHGFGDTAETIPELNSVVEHSKSVKVQERYDTAVLGTMHLHHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N9P6</accession>
    <name>A0A2I3N9P6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal peptide, CUB and EGF-like domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein CEGP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Scube/You</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SCUBE2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3N9P6"/>
    <dbReference type="Ensembl" id="ENSPANT00000032844.2">
        <property type="protein sequence ID" value="ENSPANP00000044709.2"/>
        <property type="gene ID" value="ENSPANG00000000361.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153185"/>
    <dbReference type="OMA" id="YIMHVDG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000361">
        <property type="expression patterns" value="Expressed in urinary bladder and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N9P6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000032">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000002">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000199">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000237">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000256">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000029">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000030">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000035">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF3">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="886"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044709.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1076" mass="117491" checksum="0FAC8C6086298BBD" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NB04</accession>
    <name>A0A2I3NB04_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Unconventional myosin-Ib</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Myosin I alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MYO1B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907790.1">
        <property type="nucleotide sequence ID" value="XM_003907741.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NB04"/>
    <dbReference type="Ensembl" id="ENSPANT00000032831.2">
        <property type="protein sequence ID" value="ENSPANP00000045165.2"/>
        <property type="gene ID" value="ENSPANG00000012602.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006910"/>
    <dbReference type="CTD" id="4430"/>
    <dbReference type="GeneTree" id="ENSGT00940000155752"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012602">
        <property type="expression patterns" value="Expressed in liver and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NB04">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000013">
        <property type="entry name" value="LOW QUALITY PROTEIN: unconventional myosin-Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000007">
        <property type="entry name" value="Myosin-ib isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000004">
        <property type="entry name" value="unconventional myosin-Ib isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000011">
        <property type="entry name" value="unconventional myosin-Ib isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF277">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="15"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="17">
        <location>
            <begin position="952"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045165.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1136" mass="131944" checksum="8DDB95269055B98D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NDM6</accession>
    <name>A0A2I3NDM6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCAI</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCAI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031510369.1">
        <property type="nucleotide sequence ID" value="XM_031654509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NDM6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000046090"/>
    <dbReference type="Ensembl" id="ENSPANT00000043225.2">
        <property type="protein sequence ID" value="ENSPANP00000046090.2"/>
        <property type="gene ID" value="ENSPANG00000011266.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020104"/>
    <dbReference type="CTD" id="286205"/>
    <dbReference type="GeneTree" id="ENSGT00390000009566"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011266">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016607">
        <property type="entry name" value="SCAI_metazoan/Viridiplantae"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013022">
        <property type="entry name" value="UCP013022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046090.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="606" mass="70399" checksum="08711C37BF37DB96" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-03-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2K6EE35</accession>
    <name>A0A2K6EE35_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Melanocyte-stimulating hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Melanocortin receptor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2018-02" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="AHZZ02019253">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2K6EE35"/>
    <dbReference type="Ensembl" id="ENSPANT00000000697">
        <property type="protein sequence ID" value="ENSPANP00000015446"/>
        <property type="gene ID" value="ENSPANG00000006306"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282542"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006306">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2K6EE35">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004980">
        <property type="term" value="F:melanocyte-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
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            <begin position="740"/>
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        </location>
    </feature>
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            <begin position="744"/>
            <end position="765"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MXY6</accession>
    <name>A0A8I5MXY6_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000040539.1"/>
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        <property type="component" value="Chromosome 12"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="209" mass="24651" checksum="F772C5B1B55875B7" modified="2022-05-25" version="1">MGKDFMSKTPKATAAKAKIDKWDLIKLKSFCTAKETTIRVNRQPIEWEKIFAIYSSDKGLISRTYKELTQIYKKKTNNPIKKWAKDMNRHFSKEDIHTANRHMKKCSSSLAIREMQIKTTMRYHLTPVRMAIIKKSGNNRCWRGCGEIGTLLHCWWDCKLVQPLWKTVWRFLKDLELDVPYDPANLCSQQSHEKNAHHWPLEKCKSKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MY30</accession>
    <name>A0A8I5MY30_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPANT00000074153.1">
        <property type="protein sequence ID" value="ENSPANP00000049730.1"/>
        <property type="gene ID" value="ENSPANG00000045683.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF152">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049730.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="117" mass="12815" checksum="4809D3C93E18343D" modified="2022-05-25" version="1">MRRQWRNRRSKKSTHNRKLECNGMISVLCNLCLPGSSDSPASASRAAGITGTHHHTCLNFAFLVQMGFHHVGQAGLKLLTSDDSPTSASQSAGITGMNHYAKPAKALLLTFHKSWRI</sequence>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Bandaranaike D.B."/>
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                <person name="Berhane-Mersha D.B."/>
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                <person name="Bickham C.B."/>
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                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Fernandez S.F."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPANT00000078396.1">
        <property type="protein sequence ID" value="ENSPANP00000051334.1"/>
        <property type="gene ID" value="ENSPANG00000050360.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287033"/>
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        <property type="component" value="Chromosome 12"/>
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        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
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        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="160" mass="17083" checksum="BF5ABD8A2987813C" modified="2022-05-25" version="1">MGLTLLSRLECSGAITAHCSLDLLGSSLLDLSPAQVAGTTGTRRTLHTGVYYTTPGSFFVCVFCRSGVSPCCPGLSQSPELKQSSCFSLPKCWDYRCEPPGPAMSDSLSLDRPYLQGSIVASDVPKLTEKAYSPSYIGRKVSFILGYICEVNTLAIQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZT8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
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                <person name="Davila M.L.D."/>
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                <person name="Francisco L.F."/>
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                <person name="Garcia-Iii R.G."/>
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                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZT8"/>
    <dbReference type="Ensembl" id="ENSPANT00000065049.1">
        <property type="protein sequence ID" value="ENSPANP00000048355.1"/>
        <property type="gene ID" value="ENSPANG00000048641.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170471"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="155" mass="17963" checksum="653CAD6F5CF77DAD" modified="2022-05-25" version="1">QKTNVYTDIPHFIVLHFIVLFRYFIFYKLKIFDNTAFSKSISTIFPTWPSFVPLCHILAGVQWLDLGSPQPPPPRFQRFSCLSLLSSLDYRHEQPHLANFVFSIETGFLHVGQAGLELPTSGDSPIKHSYSFPKQQYHFTVTSTRQKFQFLHILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N010</accession>
    <name>A0A8I5N010_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TAS2R4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202261.2">
        <property type="nucleotide sequence ID" value="XM_009203997.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N010"/>
    <dbReference type="SMR" id="A0A8I5N010"/>
    <dbReference type="Ensembl" id="ENSPANT00000083722.1">
        <property type="protein sequence ID" value="ENSPANP00000048488.1"/>
        <property type="gene ID" value="ENSPANG00000037718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100997660"/>
    <dbReference type="KEGG" id="panu:100997660"/>
    <dbReference type="CTD" id="50832"/>
    <dbReference type="GeneTree" id="ENSGT01150000286961"/>
    <dbReference type="OMA" id="MKLMIYF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15013">
        <property type="entry name" value="7tm_TAS2R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000055">
        <property type="entry name" value="Taste receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030055">
        <property type="entry name" value="TAS2R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF55">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 17" id="KW-0919">Taste</keyword>
    <keyword evidence="14 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="82"/>
            <end position="108"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="129"/>
            <end position="150"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="170"/>
            <end position="203"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="299" mass="34035" checksum="174C1231D54974DB" modified="2022-05-25" version="1">MLWLFYSSAIIASVILDFVGIIMSLFITVVNYKTWVKSHRISSSERILFSLGITRFFMLALFLVNTIYFVSSNKERSVYLSAFFVLCFMFLDSSSLWFVTLLNSLYCVKITNFQHSVFLLLKRNISPKIPRLLPACVLISAFTTCLYITLSQASPFPELVTKRNNTSFNISEGILSLVVSFVLSSSLQFIINVTSASLLIYSLRRHIRKMQKNATGFWNPQTEAHVGAMKLMIYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N620</accession>
    <name>A0A8I5N620_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N620"/>
    <dbReference type="Ensembl" id="ENSPANT00000065954.1">
        <property type="protein sequence ID" value="ENSPANP00000054797.1"/>
        <property type="gene ID" value="ENSPANG00000049676.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="OMA" id="QDEGNSP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF135">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="119" mass="12726" checksum="12BB83E9B11B37CE" modified="2022-05-25" version="1">MHPYLRQTISQLLAEMDGLECNGAISAHCNLCLQDSSDSPTSASQVAGITGAHHHGKLIFVFLVETGFHHVGQAGLKLLTSVDPPASASQSAGITCMNHCTQPECEFFVKSFLLPVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N706</accession>
    <name>A0A8I5N706_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N706"/>
    <dbReference type="Ensembl" id="ENSPANT00000065704.1">
        <property type="protein sequence ID" value="ENSPANP00000048654.1"/>
        <property type="gene ID" value="ENSPANG00000049445.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="CLANVCI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="79" mass="8841" checksum="C2358F3D5EBABBB0" modified="2022-05-25" version="1">MKCTQCQMASHSVTQAGVQCCDLSSLQSLLPRLKQFSCLSLLSSWDYRCALSRLANCCIFSREGVSSCWPGWFQTPDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7V1</accession>
    <name>A0A8I5N7V1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Progesterone receptor membrane component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PGRMC2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
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                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003899181.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7V1"/>
    <dbReference type="Ensembl" id="ENSPANT00000076696.1">
        <property type="protein sequence ID" value="ENSPANP00000052378.1"/>
        <property type="gene ID" value="ENSPANG00000050693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101014390"/>
    <dbReference type="KEGG" id="panu:101014390"/>
    <dbReference type="CTD" id="10424"/>
    <dbReference type="GeneTree" id="ENSGT00940000159744"/>
    <dbReference type="OMA" id="QNTIEAD"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF24">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="247" mass="25986" checksum="B58E09EEAE356DB0" modified="2022-05-25" version="1">MGGAGRGVGEGRGRGGGGRRWRAVMAAGDGDVKLGTLGSGSESSSDGGSESPGGAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGTGAGAGEESPAASLPRMKKRDFSLEQLRQYDGSGNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8K2</accession>
    <name>A0A8I5N8K2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">F-box protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FBXO5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003898074.2">
        <property type="nucleotide sequence ID" value="XM_003898025.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8K2"/>
    <dbReference type="Ensembl" id="ENSPANT00000077874.1">
        <property type="protein sequence ID" value="ENSPANP00000057499.1"/>
        <property type="gene ID" value="ENSPANG00000046787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101007895"/>
    <dbReference type="KEGG" id="panu:101007895"/>
    <dbReference type="CTD" id="26271"/>
    <dbReference type="GeneTree" id="ENSGT00530000063692"/>
    <dbReference type="OMA" id="VVLSCMQ"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032876">
        <property type="term" value="P:negative regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070169">
        <property type="term" value="P:positive regulation of biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905322">
        <property type="term" value="P:positive regulation of mesenchymal stem cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007057">
        <property type="term" value="P:spindle assembly involved in female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20364">
        <property type="entry name" value="BRcat_RBR_FBXO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22170">
        <property type="entry name" value="F-box_FBXO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000043">
        <property type="entry name" value="F-box only protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000006">
        <property type="entry name" value="F-box only protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044064">
        <property type="entry name" value="ZF_ZBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF8">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51872">
        <property type="entry name" value="ZF_ZBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZBR-type" evidence="15">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="448" mass="50295" checksum="416F577978B17018" modified="2022-05-25" version="1">MSRRPCSCAPRPPRCSCSASPSAVTAAGRPRPSDSCKEEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVELETESKPLHNKENQHVQQTLHSTNEIEALETSRLYEDSGYSSFSQQSGLSEHEEGSLLEENFSDSPQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIITRGNFRLQNIIGRKMGLECVDILSELFRRGLRHLLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREFVMFRTPLASVQKSAAQTSLKKDAQTKVSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTRCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NA07</accession>
    <name>A0A8I5NA07_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the humanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NA07"/>
    <dbReference type="Ensembl" id="ENSPANT00000083495.1">
        <property type="protein sequence ID" value="ENSPANP00000057948.1"/>
        <property type="gene ID" value="ENSPANG00000045334.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900118">
        <property type="term" value="P:negative regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028139">
        <property type="entry name" value="Humanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33895:SF16">
        <property type="entry name" value="HUMANIN-LIKE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33895">
        <property type="entry name" value="HUMANIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15040">
        <property type="entry name" value="Humanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="24" mass="2915" checksum="03FECB905B6A7D91" modified="2022-05-25" version="1">MARRVFSCLLFLSIEIDLSVKRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NB16</accession>
    <name>A0A8I5NB16_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPX8</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NB16"/>
    <dbReference type="Ensembl" id="ENSPANT00000068252.1">
        <property type="protein sequence ID" value="ENSPANP00000057365.1"/>
        <property type="gene ID" value="ENSPANG00000038979.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159371"/>
    <dbReference type="OMA" id="IMVCMGC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000049">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013376">
        <property type="entry name" value="Glut_perox_Gpx7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02540">
        <property type="entry name" value="gpx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF7">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="158" mass="18146" checksum="DF01C57483A48AEC" modified="2022-05-25" version="1">MEPLAAYPLKCSGPRAKVSLVVNVASDCQLTDRNYLALKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWRPEEPIEVIRPDIAALVRQLIIKKKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NC62</accession>
    <name>A0A8I5NC62_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NC62"/>
    <dbReference type="Ensembl" id="ENSPANT00000077350.1">
        <property type="protein sequence ID" value="ENSPANP00000055804.1"/>
        <property type="gene ID" value="ENSPANG00000039680.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF133">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="161" mass="17609" checksum="93726A3757B130F4" modified="2022-05-25" version="1">MAKPVSTKKYKKREGLALLPRRECSGAITAHCSLNLMGSSNPPTSALKVAGITGTCHHAWLIFVFFIEKGFCHVAQAGLELPSSSDSSTLTSPSAEIIGMSHCAWPAASFYRSDSFFSRFSNLWKQLGEVRNGSQGDRDSELNEPSPLVLHESKLRPREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NKK4</accession>
    <name>A0A8I5NKK4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core shell protein Gag P30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NKK4"/>
    <dbReference type="Ensembl" id="ENSPANT00000072615.1">
        <property type="protein sequence ID" value="ENSPANP00000058464.1"/>
        <property type="gene ID" value="ENSPANG00000042586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287075"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core shell protein Gag P30" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Core shell protein Gag P30" evidence="2">
        <location>
            <begin position="215"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="454" mass="51079" checksum="63C40626E977FA0D" modified="2022-05-25" version="1">PPPPENPLLRPPPYASPLPPVLSPALSSITSAPTLSPTSPSASPSTPSPSPAPPELTPRTPPPTPRLRLRRTENPDGPPTWRSSLFPLRTVNHTVQYWSFSASDLYNWKTHNPSFSQDPQALTSLIERGPPSGWEKPRALPQGPQPRRWRRRRQRRASPRLRASAGGHRLRCCGGRAGGPGEPHCAAPRRRGRAGFLRLARAAGPQSGLQPRSFVLLTTEERQRVLLEARKNVPGPGGLPTQLPNEIDEGFPLTRPDWDYETAPGRESLRIYRQALLAGLKGAGKRPTNLAKVRTITQERDESPAAFMERLLERFQMYTPFNPETLEHKATVAMAFIDQAASDIKGKLQRLDRIQTYGLQELVKEAKKVYNKRETPEEREARLAKEQEEREDRKDRKRDKHLTKILAAVVKEKRPGREGEKRRRPKVEKDQCAYCKEPWTSIPRSPTPTTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNV7</accession>
    <name>A0A8I5NNV7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNV7"/>
    <dbReference type="Ensembl" id="ENSPANT00000083676.1">
        <property type="protein sequence ID" value="ENSPANP00000060360.1"/>
        <property type="gene ID" value="ENSPANG00000050051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183010"/>
    <dbReference type="OMA" id="QVNHAPC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="179" mass="20828" checksum="12CC79922F471D0D" modified="2022-05-25" version="1">MEYLNPTKSCKSRGSNPRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGQWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVTQKKKISQKKLKKQKLMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NSS1</accession>
    <name>A0A8I5NSS1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CD2 antigen cytoplasmic tail-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CD2BP2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSS1"/>
    <dbReference type="Ensembl" id="ENSPANT00000083459.1">
        <property type="protein sequence ID" value="ENSPANP00000057429.1"/>
        <property type="gene ID" value="ENSPANG00000041870.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012483"/>
    <dbReference type="OMA" id="GENTNFY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000002">
        <property type="entry name" value="CD2 antigen cytoplasmic tail-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="GYF" evidence="15">
        <location>
            <begin position="279"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="340" mass="37423" checksum="D7989B503FB7848B" modified="2022-05-25" version="1">MPKRKVTFQGVGDEEDEDEISVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQHQASDSEEEDSLGQTPMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGRPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTVGPHNPTPPPSLDMFAEEVAEEELETPTPTQRGEAESPGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NTT7</accession>
    <name>A0A8I5NTT7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NTT7"/>
    <dbReference type="Ensembl" id="ENSPANT00000081784.1">
        <property type="protein sequence ID" value="ENSPANP00000053370.1"/>
        <property type="gene ID" value="ENSPANG00000050925.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="OMA" id="PIPHTHK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="384" mass="40773" checksum="7F9EA26319D89542" modified="2022-05-25" version="1">PCPRPPQGEVWALQPLSQTTRGGPAPSSQTTRGLPALPPRTTRGACTLFPDHIGAPRALPRPHVATLQPFPQTVGDPSRPLPRLTRALCSLGPRPQAPVASSPRLPGALAASPRTAGALQPLPRPSWGPCSLFPDQAGGPQPLPRPHGGALQPLPRPHGGPAASSQTTRGRPAASSQATRGAPAAWRPAGRGASGFEVIETSTAGSQKRNIGSLVPRPTRWLPWVSLAPVQALQTAPPPTHWSQTHESRPRTDPCVEGYRQRLGGRVLAAIPQGEPGGPPRRQHPQPPASSGKGPSDLSLHFFFFLSFFFFETESCSVAQAGVQWCDLSSLQAPPPGFPPFSCLSLPSSWDYRRPPPRPASFLYFLVETGFHRVSQDGLGLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU28</accession>
    <name>A0A8I5NU28_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PITX1</name>
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    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU28"/>
    <dbReference type="SMR" id="A0A8I5NU28"/>
    <dbReference type="Ensembl" id="ENSPANT00000069992.1">
        <property type="protein sequence ID" value="ENSPANP00000055454.1"/>
        <property type="gene ID" value="ENSPANG00000042573.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154518"/>
    <dbReference type="OMA" id="YVDLGGM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014707">
        <property type="term" value="P:branchiomeric skeletal muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035116">
        <property type="term" value="P:embryonic hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048625">
        <property type="term" value="P:myoblast fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021983">
        <property type="term" value="P:pituitary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000031">
        <property type="entry name" value="Homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016233">
        <property type="entry name" value="Homeobox_Pitx/unc30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF1">
        <property type="entry name" value="PITUITARY HOMEOBOX 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000563">
        <property type="entry name" value="Homeobox_protein_Pitx/Unc30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="15">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="348" mass="37589" checksum="6F2AF82350BC10D0" modified="2022-05-25" version="1">MRFFCEAEGELGRSQGGGARPAPAPGAPAAVPTSMDAFKGGMSLERLPEGLRPPPPPPHDMGPAFHLARPADHREQLENSASESSDTELPEKERGGESKGPEDSGTGGTGCGSADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMSPGACPYGTPASPYTVYRDTCNSSLASLRLKSKQHSSFGYGGLQGPASGLNACQYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NWS2</accession>
    <name>A0A8I5NWS2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003894207.1">
        <property type="nucleotide sequence ID" value="XM_003894158.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031518491.1">
        <property type="nucleotide sequence ID" value="XM_031662631.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519058.1">
        <property type="nucleotide sequence ID" value="XM_031663198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NWS2"/>
    <dbReference type="Ensembl" id="ENSPANT00000071230.1">
        <property type="protein sequence ID" value="ENSPANP00000058762.1"/>
        <property type="gene ID" value="ENSPANG00000039685.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000079711.1">
        <property type="protein sequence ID" value="ENSPANP00000060127.1"/>
        <property type="gene ID" value="ENSPANG00000045181.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000084012.1">
        <property type="protein sequence ID" value="ENSPANP00000051540.1"/>
        <property type="gene ID" value="ENSPANG00000038703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101017675"/>
    <dbReference type="GeneID" id="116273524"/>
    <dbReference type="GeneID" id="116273751"/>
    <dbReference type="KEGG" id="panu:101017675"/>
    <dbReference type="KEGG" id="panu:116273524"/>
    <dbReference type="KEGG" id="panu:116273751"/>
    <dbReference type="GeneTree" id="ENSGT00940000158384"/>
    <dbReference type="OMA" id="FHVCAQE"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19749">
        <property type="entry name" value="bHLH-O_DEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000020">
        <property type="entry name" value="class E basic helix-loop-helix protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="13">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45498" checksum="14EAD6069390E2C5" modified="2022-05-25" version="1">MERIPSAQPPPACLPKAPGLEHGDLPGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSDQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYT8</accession>
    <name>A0A8I5NYT8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRY-box transcription factor 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SOX21</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009190352.2">
        <property type="nucleotide sequence ID" value="XM_009192088.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NYT8"/>
    <dbReference type="SMR" id="A0A8I5NYT8"/>
    <dbReference type="Ensembl" id="ENSPANT00000084130.1">
        <property type="protein sequence ID" value="ENSPANP00000060507.1"/>
        <property type="gene ID" value="ENSPANG00000042059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101004306"/>
    <dbReference type="KEGG" id="panu:101004306"/>
    <dbReference type="CTD" id="11166"/>
    <dbReference type="GeneTree" id="ENSGT00940000162795"/>
    <dbReference type="OMA" id="LHGHEAF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001942">
        <property type="term" value="P:hair follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF313">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="276" mass="28580" checksum="99DC899B7EC9A96B" modified="2022-05-25" version="1">MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGGVADAEHPALKAGAGLHAGAGGGLVPESLLANPEKAAAAAAAAAARVFFPQSAAAAAAAAAAAAAGSPYSLLDLGSKMAEISSSSSGLPYASSLGYPTAGAGAFHGAAAAAAAAAAAAGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2K4</accession>
    <name>A0A8I5P2K4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P2K4"/>
    <dbReference type="Ensembl" id="ENSPANT00000065402.1">
        <property type="protein sequence ID" value="ENSPANP00000059287.1"/>
        <property type="gene ID" value="ENSPANG00000037605.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="OMA" id="MSHYAWS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035186843" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12034" checksum="2D21E313EC4CE876" modified="2022-05-25" version="1">MSHYAWSYFLFFFLRWSLTLLLSLECSGTISAHCSLHLPGSSDSPASASQVAGMTGTCRHAQLNFLCVFLVEMGFHHFGQARLELLTSSDPPTLASQSAGITGMSHLAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2T6</accession>
    <name>A0A8I5P2T6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P2T6"/>
    <dbReference type="Ensembl" id="ENSPANT00000064786.1">
        <property type="protein sequence ID" value="ENSPANP00000059491.1"/>
        <property type="gene ID" value="ENSPANG00000042576.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="143" mass="16385" checksum="57CFB27D96B586AF" modified="2022-05-25" version="1">MCSCRGEEISIYLLRVYGWPIFFFFFFFFFFFFETESHSVTQAGERWHNLGSLQPLPPPSSYRLWDYRHAPPRQANIFVFLVEMGFHHVGQAGLELRTSGDLLALASQSAGITSMSHCAQPQFCFQGAFAHPQWVAAPQKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5QZ98</accession>
    <name>A0A8I5QZ98_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">OR4K15</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5QZ98"/>
    <dbReference type="Ensembl" id="ENSPANT00000008445.3">
        <property type="protein sequence ID" value="ENSPANP00000048526.1"/>
        <property type="gene ID" value="ENSPANG00000024792.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101021626"/>
    <dbReference type="GeneTree" id="ENSGT00940000159214"/>
    <dbReference type="OMA" id="RNCFLET"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15226">
        <property type="entry name" value="7tmA_OR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000012">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="65"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="344" mass="38441" checksum="68872C6A4F307B9D" modified="2022-05-25" version="1">MLTSLTDLCFSPIQVTETKSLPKSMNETNHSRVTEFVLLGLSSSRELQPFLFLIFSLFYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDVCVASFATPKMIADSLVEHKTISFDACLAQIFFVHLFTGSEMVLLVSMAYDRYVAICKPLHYMTIMSRRVCVVLVLISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACTDTYVVSLLIVADSGFLSLSSFLLLVVSYTVILVTVRNRSSASMAKARSTLTAHITVVTLFFGPCIFIYVWPFSSYSVDKVLAVFYTIFTPILNPVIYTLRNKEVKAAMSKLKSRYLKPGQVSAVIRNALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6R2</accession>
    <name>A0A8I5R6R2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Condensin-2 complex subunit G2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Chromosome-associated protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Leucine zipper protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Non-SMC condensin II complex subunit G2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NCAPG2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003896983.2">
        <property type="nucleotide sequence ID" value="XM_003896934.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792179.2">
        <property type="nucleotide sequence ID" value="XM_021936487.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792180.2">
        <property type="nucleotide sequence ID" value="XM_021936488.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520822.1">
        <property type="nucleotide sequence ID" value="XM_031664962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6R2"/>
    <dbReference type="Ensembl" id="ENSPANT00000083028.1">
        <property type="protein sequence ID" value="ENSPANP00000052423.1"/>
        <property type="gene ID" value="ENSPANG00000006916.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997535"/>
    <dbReference type="KEGG" id="panu:100997535"/>
    <dbReference type="CTD" id="54892"/>
    <dbReference type="GeneTree" id="ENSGT00490000043432"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000238">
        <property type="entry name" value="Non-SMC condensin II complex subunit G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1143" mass="130967" checksum="69848725A9370BE5" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R6S2</accession>
    <name>A0A8I5R6S2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R6S2"/>
    <dbReference type="Ensembl" id="ENSPANT00000073512.1">
        <property type="protein sequence ID" value="ENSPANP00000052447.1"/>
        <property type="gene ID" value="ENSPANG00000047329.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="QCDETEK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161270">
        <property type="entry name" value="PspA lactotransferrin-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="16">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="15">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="17">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="40224" checksum="5DB42E4E2833D9B5" modified="2022-05-25" version="1">MGKKQCRKAGNSKNQSAYPPPKERRSSPAMEQSWMENDFDELREEGFSRSNFSELKEELRNQRKEIKNREKRMDEWITRIINAEKTLTELIEMKTMTRELRDKCTSFSNRLDQLEERVSAIEDQMNEMKQEEKCREKRVKSNEQSLQEIWDYVKRPNLRLIGVPESDGENGTKLENTLQDIIEENFPNLVRQANIQIQEIQRTPQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKCRVTHKGKPIRLTADLSAESLQARREWGPIFNILKEKNFQPRISYQAKLSFISEGEIKSFTNKQMLRDFVTTRPALQDILKEALNMERKNRYQPLQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLP4</accession>
    <name>A0A096MLP4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Hepatitis A virus cellular receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HAVCR1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the immunoglobulin superfamily. TIM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MLP4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000473"/>
    <dbReference type="Ensembl" id="ENSPANT00000020105.3">
        <property type="protein sequence ID" value="ENSPANP00000000473.3"/>
        <property type="gene ID" value="ENSPANG00000013258.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159345"/>
    <dbReference type="HOGENOM" id="CLU_047504_2_1_1"/>
    <dbReference type="OMA" id="EHSPQMV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013258">
        <property type="expression patterns" value="Expressed in metanephros cortex and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033005">
        <property type="term" value="P:positive regulation of mast cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000774">
        <property type="entry name" value="Hepatitis A virus cellular receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052331">
        <property type="entry name" value="TIM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47009:SF1">
        <property type="entry name" value="HEPATITIS A VIRUS CELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47009">
        <property type="entry name" value="HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199415" evidence="13">
        <location>
            <begin position="18"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000473.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="372" mass="40068" checksum="70A9B8016F6381FA" modified="2022-05-25" version="3">MHPQVVILSLILHLADSVADSVNVDGVAGLPITLPCRYNGAITSMCWNRGTCSVFSCPDGIVWTNGTHVTYRKETRYKLLGNLSRRDVSLTIANTAVSDSGIYCCRVQHRGWFNDIKITISLKIGPPRVTTTPIVRTVQTRTTLPTTTTLPTTTTLPTTTTLPTTTTLPTTTTLPMTTLPMTTTLPMTTTLPTTTTLPTTTTLPTTTTLPTTTTLPTTMTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTMVSTFVPPTPLPMQNHEPVATSPSSPQPAETHPVTLLGATRTQPTSSPLYSYTTDGSDTVTESSDGLWNNNQTQLSPEHSPQMVNTTEGIYAGVSISVLVLLAVLGVVIAKKYFFKKEIQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MM70</accession>
    <name>A0A096MM70_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909516.1">
        <property type="nucleotide sequence ID" value="XM_003909467.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MM70"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000693"/>
    <dbReference type="Ensembl" id="ENSPANT00000009514.3">
        <property type="protein sequence ID" value="ENSPANP00000000693.2"/>
        <property type="gene ID" value="ENSPANG00000007007.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010536"/>
    <dbReference type="KEGG" id="panu:101010536"/>
    <dbReference type="CTD" id="80194"/>
    <dbReference type="eggNOG" id="KOG4753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011766"/>
    <dbReference type="HOGENOM" id="CLU_120539_0_0_1"/>
    <dbReference type="OMA" id="WRSPPCH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007007">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039714">
        <property type="entry name" value="TMEM134"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000693.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="195" mass="21596" checksum="008E9E2046126CAA" modified="2018-02-28" version="2">MSAARPQFSIDDAFELSLEDAGPGPEASGVARFGPLHFERRARFEVADEDKQSRLRYQNLENDEDGAQISPEPDGGVSTRDSGRTSIRSSQWSFSTISSGTQRSYNTCCSWTQHPLIQKNRRVVLASFLLLLLGLVLILVGVGLEATPSPGVSSAIFFVPGFLLLVPGVYHVIFIYCAVKGHRGFQFFYLPYFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNZ5</accession>
    <name>A0A096MNZ5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MNZ5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001427"/>
    <dbReference type="Ensembl" id="ENSPANT00000010659.3">
        <property type="protein sequence ID" value="ENSPANP00000001427.3"/>
        <property type="gene ID" value="ENSPANG00000014419.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013067"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OMA" id="TRRIWPQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014419">
        <property type="expression patterns" value="Expressed in pancreas and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000184">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001427.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="139" mass="15803" checksum="FA03D2B9B14B3B97" modified="2022-05-25" version="3">MPSKGPLQSVQVFVRKKTATAVAHCKRRNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQYDRTLLVAEIWPLHSSLGDRKSETLSQTRRIWPQSTYLFSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MP66</accession>
    <name>A0A096MP66_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ubiquitin carboxyl-terminal hydrolase 25</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Deubiquitinating enzyme 25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquitin thioesterase 25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Ubiquitin-specific-processing protease 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">USP25</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer, inhibited form. Homodimer, active form. Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003895662.1">
        <property type="nucleotide sequence ID" value="XM_003895613.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MP66"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001505"/>
    <dbReference type="MEROPS" id="C19.041"/>
    <dbReference type="Ensembl" id="ENSPANT00000017180.3">
        <property type="protein sequence ID" value="ENSPANP00000001505.1"/>
        <property type="gene ID" value="ENSPANG00000009692.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101022176"/>
    <dbReference type="CTD" id="29761"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157962"/>
    <dbReference type="OMA" id="PTMQGII"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009692">
        <property type="expression patterns" value="Expressed in gastrocnemius and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MP66">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038173">
        <property type="term" value="P:interleukin-17A-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903882">
        <property type="term" value="P:negative regulation of interleukin-17-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902883">
        <property type="term" value="P:negative regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02665">
        <property type="entry name" value="Peptidase_C19I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14354">
        <property type="entry name" value="UBA_UBP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20486">
        <property type="entry name" value="USP25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000023">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000004">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054108">
        <property type="entry name" value="USP25/28_UIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF666">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21909">
        <property type="entry name" value="USP_UIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="25">
        <location>
            <begin position="169"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1125" mass="129945" checksum="49A9850998C3C540" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPR9</accession>
    <name>A0A096MPR9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b-c1 complex subunit 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex III subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Core protein I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquinol-cytochrome-c reductase complex core protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UQCRC1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6. Interacts with STMP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MPR9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001731"/>
    <dbReference type="Ensembl" id="ENSPANT00000003911.3">
        <property type="protein sequence ID" value="ENSPANP00000001731.2"/>
        <property type="gene ID" value="ENSPANG00000015008.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158931"/>
    <dbReference type="HOGENOM" id="CLU_009902_4_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015008">
        <property type="expression patterns" value="Expressed in ascending colon and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MPR9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000016">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF116">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="17">
        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="18">
        <location>
            <begin position="210"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001731.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="480" mass="52792" checksum="36AABDF0B6955CFA" modified="2022-05-25" version="2">MAASVVCRAATSGAQVLLRARRSPTLLRTPALRSTATFAQALQFVPETQVSLLDNGLRVASEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKVVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMRDVVFDYLHATAFQGTPLAQAVEGPSENVRKLSRADLTEYLNTHYKAPRMVLAAAGGVEHQQLLDLAQKHLGDIPWTYAEDTVPALTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPDNVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYADTGLLGAHFVCDRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVB8</accession>
    <name>A0A096MVB8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metastasis-associated in colon cancer protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SH3 domain-containing protein 7a5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MACC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with FASLG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MVB8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003793"/>
    <dbReference type="Ensembl" id="ENSPANT00000015116.3">
        <property type="protein sequence ID" value="ENSPANP00000003793.3"/>
        <property type="gene ID" value="ENSPANG00000006404.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QZDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013151"/>
    <dbReference type="HOGENOM" id="CLU_013080_1_0_1"/>
    <dbReference type="OMA" id="PPMLNHD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006404">
        <property type="expression patterns" value="Expressed in esophagus and 32 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000012">
        <property type="entry name" value="Metastasis-associated in colon cancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056183">
        <property type="entry name" value="DEATH_SH3BP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056181">
        <property type="entry name" value="SH3BP4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056182">
        <property type="entry name" value="UPA_SH3BP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15603:SF1">
        <property type="entry name" value="METASTASIS-ASSOCIATED IN COLON CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15603">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24094">
        <property type="entry name" value="DEATH_SH3BP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23637">
        <property type="entry name" value="SH3BP4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23640">
        <property type="entry name" value="UPA_SH3BP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ZU5" evidence="15">
        <location>
            <begin position="187"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="524"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003793.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="827" mass="93840" checksum="4FA36357829DBDA9" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWM6</accession>
    <name>A0A096MWM6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">WD repeat and FYVE domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">WDFY3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031520441.1">
        <property type="nucleotide sequence ID" value="XM_031664581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520442.1">
        <property type="nucleotide sequence ID" value="XM_031664582.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000004284"/>
    <dbReference type="Ensembl" id="ENSPANT00000017258.3">
        <property type="protein sequence ID" value="ENSPANP00000004284.2"/>
        <property type="gene ID" value="ENSPANG00000022290.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004659"/>
    <dbReference type="CTD" id="23001"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155680"/>
    <dbReference type="HOGENOM" id="CLU_000175_5_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022290">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWM6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000028">
        <property type="entry name" value="Putative hepatocyte growth factor-regulated tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000095">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000293">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF1">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <sequence length="3526" mass="395443" checksum="4E87573B62A6B9C0" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX63</accession>
    <name>A0A096MX63_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VEZT</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
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            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_009181439.3"/>
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        <property type="protein sequence ID" value="ENSPANP00000004474.2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    <sequence length="783" mass="89239" checksum="1AB2495D4A9ED5E7" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYK0</accession>
    <name>A0A096MYK0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SARAF</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with STIM1; the interaction is inhibited by the interaction of STIM1 with EFHB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021797872.2">
        <property type="nucleotide sequence ID" value="XM_021942180.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYK0"/>
    <dbReference type="SMR" id="A0A096MYK0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005017"/>
    <dbReference type="Ensembl" id="ENSPANT00000022450.3">
        <property type="protein sequence ID" value="ENSPANP00000005017.3"/>
        <property type="gene ID" value="ENSPANG00000005235.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007936"/>
    <dbReference type="KEGG" id="panu:101007936"/>
    <dbReference type="CTD" id="51669"/>
    <dbReference type="eggNOG" id="ENOG502QT6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013419"/>
    <dbReference type="HOGENOM" id="CLU_046802_2_2_1"/>
    <dbReference type="OMA" id="WILKGSC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005235">
        <property type="expression patterns" value="Expressed in suprachiasmatic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173225" description="Store-operated calcium entry-associated regulatory factor" evidence="18">
        <location>
            <begin position="31"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005017.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="339" mass="37010" checksum="89393F35787DF393" modified="2022-05-25" version="3">MAVACGPGAAGHCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWYSADSCNMGGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLRGGLGGYSACSNSDTKTRTASGYGGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZ35</accession>
    <name>A0A096MZ35_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
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            <begin position="24"/>
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            <begin position="47"/>
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            <begin position="228"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0J2</accession>
    <name>A0A096N0J2_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Family with sequence similarity 180 member B</fullName>
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        <name evidence="2" type="primary">FAM180B</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 12"/>
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        <property type="expression patterns" value="Expressed in aorta and 35 other cell types or tissues"/>
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        <property type="entry name" value="FAM180"/>
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        <property type="entry name" value="PROTEIN FAM180A-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR34034:SF1">
        <property type="entry name" value="PROTEIN FAM180B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184844" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005779.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="183" mass="20207" checksum="E29B30CEB0B1F662" modified="2022-05-25" version="3">MAATLQFLACLVVAICLLSGVTTTQHHAGQPMDSTSVGGGLQKPEAPEVMFELLWAGLELDVMGQLHIQDEELASTHPGRRLRLLLQHHVPSDLEGAEQRLQQLQDLRKGPPLSTWDFEHLLLTGLSCVYRLHAASEAEERGRWAQVFTLLAQETLWDLCKGFCPQDQPPSLGSWASILDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N4F2</accession>
    <name>A0A096N4F2_PAPAN</name>
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        <recommendedName>
            <fullName evidence="7">Dipeptidyl peptidase 1</fullName>
            <ecNumber evidence="6">3.4.14.1</ecNumber>
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            <fullName evidence="17">Cathepsin C</fullName>
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        <alternativeName>
            <fullName evidence="16">Cathepsin J</fullName>
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        <alternativeName>
            <fullName evidence="19">Dipeptidyl peptidase I</fullName>
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        <alternativeName>
            <fullName evidence="18">Dipeptidyl transferase</fullName>
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        <name evidence="23" type="primary">CTSC</name>
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        <name type="scientific">Papio anubis</name>
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        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.</text>
            <dbReference type="EC" id="3.4.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_003910570.2">
        <property type="nucleotide sequence ID" value="XM_003910521.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N4F2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007269"/>
    <dbReference type="MEROPS" id="C01.070"/>
    <dbReference type="Ensembl" id="ENSPANT00000006186.3">
        <property type="protein sequence ID" value="ENSPANP00000007269.2"/>
        <property type="gene ID" value="ENSPANG00000006475.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101017791"/>
    <dbReference type="KEGG" id="panu:101017791"/>
    <dbReference type="CTD" id="1075"/>
    <dbReference type="GeneTree" id="ENSGT00940000155787"/>
    <dbReference type="HOGENOM" id="CLU_048219_0_0_1"/>
    <dbReference type="OMA" id="NAVQKSW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006475">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N4F2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016505">
        <property type="term" value="F:peptidase activator activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031642">
        <property type="term" value="P:negative regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903980">
        <property type="term" value="P:positive regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001913">
        <property type="term" value="P:T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02621">
        <property type="entry name" value="Peptidase_C1A_CathepsinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.80:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000062">
        <property type="entry name" value="Dipeptidyl peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039412">
        <property type="entry name" value="CatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018539074" description="Dipeptidyl peptidase 1" evidence="21">
        <location>
            <begin position="25"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="22">
        <location>
            <begin position="231"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007269.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="463" mass="51889" checksum="0E5286D874CE58A7" modified="2018-02-28" version="2">MGVGPASLLAALLLLLSGDRAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPPEKKVVVHLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGIKVTIYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIKRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASVGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVYHGPLSVAFEVYDDFLHYQNGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTSWGEDGYFRIRRGTDECAIESIAVAATPIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N4L7</accession>
    <name>A0A096N4L7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear envelope integral membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NEMP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021778971.1">
        <property type="nucleotide sequence ID" value="XM_021923279.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N4L7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007342"/>
    <dbReference type="Ensembl" id="ENSPANT00000011293.3">
        <property type="protein sequence ID" value="ENSPANP00000007342.1"/>
        <property type="gene ID" value="ENSPANG00000022961.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022854"/>
    <dbReference type="CTD" id="23306"/>
    <dbReference type="eggNOG" id="KOG3817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002174"/>
    <dbReference type="HOGENOM" id="CLU_025225_0_0_1"/>
    <dbReference type="OMA" id="MAGCMKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022961">
        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N4L7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043131">
        <property type="term" value="P:erythrocyte enucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF2">
        <property type="entry name" value="NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="444" mass="50998" checksum="9622B1521439DCA8" modified="2014-11-26" version="1">MAGGMKVAVSPAVGPGPWGWGVGGGRTVRLLLILSGCLVYGTAEIDVNVVMLQESQVCEKRASQQFCYTNVLIPKWHDIWTRIQIRVNSSKLIRVTQVENEDKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEIIEKDTKYSVIVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMSVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQLVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTKNLEYPIQWLYITYRKVYKATEKPVPPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFVEGSSHLTPNEVSVHEQEYGLGSIIAQDEIYEEASSEEEDSYSRCPAITQNNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5L4</accession>
    <name>A0A096N5L4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor protein p63 regulated 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TPRG1L</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891055.4">
        <property type="nucleotide sequence ID" value="XM_003891006.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N5L4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007727"/>
    <dbReference type="Ensembl" id="ENSPANT00000008557.3">
        <property type="protein sequence ID" value="ENSPANP00000007727.3"/>
        <property type="gene ID" value="ENSPANG00000009812.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998437"/>
    <dbReference type="KEGG" id="panu:100998437"/>
    <dbReference type="CTD" id="127262"/>
    <dbReference type="eggNOG" id="ENOG502QTYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001652"/>
    <dbReference type="HOGENOM" id="CLU_066718_1_0_1"/>
    <dbReference type="OMA" id="WNPWSSN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009812">
        <property type="expression patterns" value="Expressed in adrenal cortex and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N5L4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050805">
        <property type="term" value="P:negative regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF7">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007727.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="272" mass="30272" checksum="D8BA7D83E26B3296" modified="2022-05-25" version="3">MLQLRDSVDSASTSPTAVLAAGEEVGAGGGPGGGRPGTGTPLRQTLWPLSIHDPTRRARVKEYFVFRPGSIEQAVEEIRVVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTEQSLLICKYDFISLQCQQVVRIALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFINRWNPWSTNVPYATFTEHPMAGADEKTASLCQLESFKALLIQAVKKAQKESPLPGQANGVLILERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5P2</accession>
    <name>A0A096N5P2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SFT2D2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893567.1">
        <property type="nucleotide sequence ID" value="XM_003893518.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N5P2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007755"/>
    <dbReference type="Ensembl" id="ENSPANT00000019062.3">
        <property type="protein sequence ID" value="ENSPANP00000007755.1"/>
        <property type="gene ID" value="ENSPANG00000008888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001702"/>
    <dbReference type="KEGG" id="panu:101001702"/>
    <dbReference type="CTD" id="375035"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018525"/>
    <dbReference type="HOGENOM" id="CLU_099529_2_2_1"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008888">
        <property type="expression patterns" value="Expressed in thymus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N5P2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF1">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="160" mass="17763" checksum="F9F7CF33CABAAF53" modified="2014-11-26" version="1">MDKLKKVLSGQDTEDRSGLSEVVEASSLSWGTRIKGFIACFAIGILCSLLGTLLLWVPRKGLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRMFEPTRLIATIMVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSFIPFARDAVKKCFAVCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N659</accession>
    <name>A0A096N659_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyhomeotic homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N659"/>
    <dbReference type="Ensembl" id="ENSPANT00000007068.4">
        <property type="protein sequence ID" value="ENSPANP00000007946.2"/>
        <property type="gene ID" value="ENSPANG00000040013.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156612"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023504">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N659">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09577">
        <property type="entry name" value="SAM_Ph1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000011">
        <property type="entry name" value="Polyhomeotic-like protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.160:FF:000002">
        <property type="entry name" value="Polyhomeotic-like protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.160">
        <property type="match status" value="1"/>
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    <evidence type="ECO:0000256" key="9">
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="958" mass="100346" checksum="68D4DD84064E5195" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N6P2</accession>
    <name>A0A096N6P2_PAPAN</name>
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        <recommendedName>
            <fullName evidence="11">choline-phosphate cytidylyltransferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="primary">PCYT1B</name>
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    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.</text>
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    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phosphocholine + CTP + H(+) = CDP-choline + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
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        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:18998"/>
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    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
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    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
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        <property type="gene ID" value="ENSPANG00000002970.3"/>
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        <property type="reaction ID" value="UER00739"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002970">
        <property type="expression patterns" value="Expressed in testis and 54 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:phosphatidylcholine binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ovarian follicle development"/>
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        <property type="project" value="Ensembl"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008160.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="349" mass="39919" checksum="5F311DFB4AF8741E" modified="2022-05-25" version="2">MSHHASEYGILSSRVSWVWTLTAPAPFADETNCQCRAPHEKLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASISSMSEGDEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7H6</accession>
    <name>A0A096N7H6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein 34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA-binding motif protein 34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RBM34</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009195497.1">
        <property type="nucleotide sequence ID" value="XM_009197233.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N7H6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008501"/>
    <dbReference type="Ensembl" id="ENSPANT00000024882.3">
        <property type="protein sequence ID" value="ENSPANP00000008501.2"/>
        <property type="gene ID" value="ENSPANG00000010411.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103880656"/>
    <dbReference type="KEGG" id="panu:103880656"/>
    <dbReference type="CTD" id="23029"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011249"/>
    <dbReference type="HOGENOM" id="CLU_050628_0_0_1"/>
    <dbReference type="OMA" id="CAVPKKG"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010411">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12394">
        <property type="entry name" value="RRM1_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000511">
        <property type="entry name" value="RNA binding motif protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000561">
        <property type="entry name" value="RNA-binding protein 34 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="185"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="429" mass="48138" checksum="0E9F9F9E8207E098" modified="2018-02-28" version="2">MALEGMNKRKRKRSVEEGENPDDGVRGSPPGDYRVGQVASSLCRGEHHSRGGTGRLAALFSSLEPQIQPVYVPVPKETIKKRKRNEEEESTSQIERPLLQEPAKKVKAKKKHTNAEKKLANRESALASADLEEEIHQKQGQKRKNSQPGVKVADRKILDDVDDTVVSQRKKIQINEEEERLKNERTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRVDLASETSSRDKRSVFVGNLPYKVAESAVEKHFLDCGSVMAVRIVRDQVTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKLKQQNSNPRLKNIGKPKQGLNFTSKAAEGHSKSLFIGEKAVLKTKKKGQKKSGCPKKQRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7P4</accession>
    <name>A0A096N7P4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">USP53</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_021794441.1">
        <property type="nucleotide sequence ID" value="XM_021938749.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N7P4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008583"/>
    <dbReference type="Ensembl" id="ENSPANT00000026832.3">
        <property type="protein sequence ID" value="ENSPANP00000008583.2"/>
        <property type="gene ID" value="ENSPANG00000001095.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023376"/>
    <dbReference type="KEGG" id="panu:101023376"/>
    <dbReference type="CTD" id="54532"/>
    <dbReference type="eggNOG" id="KOG1887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156337"/>
    <dbReference type="HOGENOM" id="CLU_287278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001095">
        <property type="expression patterns" value="Expressed in esophagus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N7P4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010996">
        <property type="term" value="P:response to auditory stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000041">
        <property type="entry name" value="Inactive ubiquitin carboxyl-terminal hydrolase 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF6">
        <property type="entry name" value="INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="30"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008583.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120815" checksum="3DE7E2BFB8FF0F37" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N7U2</accession>
    <name>A0A096N7U2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 17">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="17">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N7U2"/>
    <dbReference type="Ensembl" id="ENSPANT00000000781.3">
        <property type="protein sequence ID" value="ENSPANP00000008653.2"/>
        <property type="gene ID" value="ENSPANG00000002060.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009405"/>
    <dbReference type="HOGENOM" id="CLU_060944_3_0_1"/>
    <dbReference type="OMA" id="EKIFCHT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000008">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025038"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008653.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="104" mass="11641" checksum="0D91394520191DDD" modified="2022-05-25" version="1">MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQARGYSYTAASKNKGITWGEDTLMEYLENPKKYIPGTKMIFVGIKKEERADLIAYLKKATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N897</accession>
    <name>A0A096N897_PAPAN</name>
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        <recommendedName>
            <fullName evidence="17">Acyloxyacyl hydrolase</fullName>
            <ecNumber evidence="16">3.1.1.77</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="19" type="primary">AOAH</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="14">
            <text>a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:136853"/>
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        </reaction>
    </comment>
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        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    <comment type="subunit">
        <text evidence="15">Heterodimer of the large and small subunits; disulfide-linked.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
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        <property type="gene ID" value="ENSPANG00000014130.3"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR15010">
        <property type="entry name" value="ACYLOXYACYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYLOXYACYL HYDROLASE"/>
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    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
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    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="24"/>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008823.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="562" mass="63934" checksum="CFBEDF5EC308DDAD" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA73</accession>
    <name>A0A096NA73_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF35</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894624.2">
        <property type="nucleotide sequence ID" value="XM_003894575.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009199275.2">
        <property type="nucleotide sequence ID" value="XM_009201011.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519276.1">
        <property type="nucleotide sequence ID" value="XM_031663416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NA73"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009577"/>
    <dbReference type="Ensembl" id="ENSPANT00000008554.3">
        <property type="protein sequence ID" value="ENSPANP00000009577.2"/>
        <property type="gene ID" value="ENSPANG00000011081.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022167"/>
    <dbReference type="KEGG" id="panu:101022167"/>
    <dbReference type="CTD" id="7584"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162289"/>
    <dbReference type="HOGENOM" id="CLU_002678_47_0_1"/>
    <dbReference type="OMA" id="VNDCHLP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011081">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NA73">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000002">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000003">
        <property type="entry name" value="Zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000165">
        <property type="entry name" value="Zinc finger protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001288">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009577.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="527" mass="59202" checksum="04EFE6FA6AFF3B24" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NB70</accession>
    <name>A0A096NB70_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">H2BC26</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NB70"/>
    <dbReference type="SMR" id="A0A096NB70"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009991"/>
    <dbReference type="Ensembl" id="ENSPANT00000003884.3">
        <property type="protein sequence ID" value="ENSPANP00000009991.1"/>
        <property type="gene ID" value="ENSPANG00000042066.1"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101020272"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT01150000286984"/>
    <dbReference type="HOGENOM" id="CLU_075666_2_1_1"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="Bgee" id="ENSPANG00000035306">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="126" mass="13908" checksum="F1E12FE400DCF25E" modified="2014-11-26" version="1">MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NC85</accession>
    <name>A0A096NC85_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ATP6V1G3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893398.1">
        <property type="nucleotide sequence ID" value="XM_003893349.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009189017.1">
        <property type="nucleotide sequence ID" value="XM_009190753.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NC85"/>
    <dbReference type="Ensembl" id="ENSPANT00000014039.3">
        <property type="protein sequence ID" value="ENSPANP00000010426.1"/>
        <property type="gene ID" value="ENSPANG00000007958.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004961"/>
    <dbReference type="KEGG" id="panu:101004961"/>
    <dbReference type="CTD" id="127124"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160882"/>
    <dbReference type="HOGENOM" id="CLU_125101_1_1_1"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007958">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NC85">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF5">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="118" mass="13849" checksum="667F8F5002CE3E66" modified="2014-11-26" version="1">MTSQSQGIHQLLQAEKRAKDKLEEAKKRKGKRLKQAKEEAMVEIDQYRMQRDKEFRLIQSKIMGSQSNLSDEIEEQTLGKIQELNGHYNKHMESVMNQLLSMVCDMKPEIHVNYRATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGA4</accession>
    <name>A0A096NGA4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Decorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DCN</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">May affect the rate of fibrils formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Secreted</location>
            <location evidence="1 13 14">Extracellular space</location>
            <location evidence="1 13 14">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017801590.2">
        <property type="nucleotide sequence ID" value="XM_017946101.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021778443.1">
        <property type="nucleotide sequence ID" value="XM_021922751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021778444.1">
        <property type="nucleotide sequence ID" value="XM_021922752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGA4"/>
    <dbReference type="SMR" id="A0A096NGA4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000021614"/>
    <dbReference type="Ensembl" id="ENSPANT00000027995.3">
        <property type="protein sequence ID" value="ENSPANP00000011974.2"/>
        <property type="gene ID" value="ENSPANG00000011237.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018003"/>
    <dbReference type="KEGG" id="panu:101018003"/>
    <dbReference type="CTD" id="1634"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158382"/>
    <dbReference type="HOGENOM" id="CLU_000288_186_0_1"/>
    <dbReference type="OMA" id="FRCIYER"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011237">
        <property type="expression patterns" value="Expressed in zone of skin and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NGA4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010596">
        <property type="term" value="P:negative regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900747">
        <property type="term" value="P:negative regulation of vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051901">
        <property type="term" value="P:positive regulation of mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000038">
        <property type="entry name" value="Biglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016352">
        <property type="entry name" value="SLRP_I_decor/aspor/byglycan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF14">
        <property type="entry name" value="DECORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002490">
        <property type="entry name" value="SLRP_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13 14" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13 14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015017777" description="Decorin" evidence="13 14">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011974.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="359" mass="39859" checksum="85D0B95C3AC122D7" modified="2018-02-28" version="2">MKVTIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPELPDDRDYEPPLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKISPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKTTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISVVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NH75</accession>
    <name>A0A096NH75_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glycoprotein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GP2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003916668.3">
        <property type="nucleotide sequence ID" value="XM_003916619.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NH75"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012323"/>
    <dbReference type="Ensembl" id="ENSPANT00000027438.3">
        <property type="protein sequence ID" value="ENSPANP00000012323.2"/>
        <property type="gene ID" value="ENSPANG00000021755.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016061"/>
    <dbReference type="KEGG" id="panu:101016061"/>
    <dbReference type="CTD" id="2813"/>
    <dbReference type="eggNOG" id="ENOG502QT6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156038"/>
    <dbReference type="HOGENOM" id="CLU_028679_1_0_1"/>
    <dbReference type="OMA" id="AHICFDP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021755">
        <property type="expression patterns" value="Expressed in pancreas and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003823">
        <property type="term" value="F:antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000001">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3210:FF:000003">
        <property type="entry name" value="Glycoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017977">
        <property type="entry name" value="ZP_dom_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF16">
        <property type="entry name" value="PANCREATIC SECRETORY GRANULE MEMBRANE MAJOR GLYCOPROTEIN GP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035283424" evidence="15">
        <location>
            <begin position="29"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="16">
        <location>
            <begin position="225"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012323.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="534" mass="59109" checksum="37E5E06663523CE0" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NK65</accession>
    <name>A0A096NK65_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Active regulator of SIRT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S19-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS19BP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AROS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905615.1">
        <property type="nucleotide sequence ID" value="XM_003905566.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NK65"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013370"/>
    <dbReference type="Ensembl" id="ENSPANT00000009738.3">
        <property type="protein sequence ID" value="ENSPANP00000013370.1"/>
        <property type="gene ID" value="ENSPANG00000015140.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013249"/>
    <dbReference type="KEGG" id="panu:101013249"/>
    <dbReference type="CTD" id="91582"/>
    <dbReference type="eggNOG" id="ENOG502S1CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016774"/>
    <dbReference type="HOGENOM" id="CLU_152637_0_0_1"/>
    <dbReference type="OMA" id="KFQREYF"/>
    <dbReference type="OrthoDB" id="6493910at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015140">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023262">
        <property type="entry name" value="AROS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31454">
        <property type="entry name" value="ACTIVE REGULATOR OF SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31454:SF2">
        <property type="entry name" value="ACTIVE REGULATOR OF SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15684">
        <property type="entry name" value="AROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02029">
        <property type="entry name" value="ACTREGSIRT1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="137" mass="15592" checksum="AB0B466BA7EA1ED4" modified="2014-11-26" version="1">MSAALLRRGLELLAASEAPRDPPGQTKPRGAPVKRPRKTKAIQAQKLRNSAKGKVPKSALDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRKACDRPVAKTKKKKKAEGTVFTEEDFQKFQQEYFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMF7</accession>
    <name>A0A096NMF7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha- and gamma-adaptin-binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AAGAB</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in endocytic recycling of growth factor receptors such as EGFR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with AP-1 and AP-2 complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NMF7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014166"/>
    <dbReference type="Ensembl" id="ENSPANT00000002105.4">
        <property type="protein sequence ID" value="ENSPANP00000014166.2"/>
        <property type="gene ID" value="ENSPANG00000016628.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007218"/>
    <dbReference type="HOGENOM" id="CLU_056826_0_0_1"/>
    <dbReference type="OMA" id="NEASHSF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016628">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11960:FF:000001">
        <property type="entry name" value="alpha- and gamma-adaptin-binding protein p34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014166.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="404" mass="44145" checksum="1E1A636D6ABD360D" modified="2022-05-25" version="2">MARSRNCYLRGGAVSKHRNLQPGPLVPMATLRAAWPVPCRERKGVWGRGQGSLVIPRTPSPACLPLAPAAMVQSKAEAAARRNRLASAAMAAGVPCALVTSCSSAFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAEAWLPEVMILVCDRVSEDGVSRQKAQEWCIRHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFNLLNSLTGTNHSIGSADPCHPEQPHLPAADRTESLSDHRSGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMQ3</accession>
    <name>A0A096NMQ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 29">Cholesterol side-chain cleavage enzyme, mitochondrial</fullName>
            <ecNumber evidence="6 29">1.14.15.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Cholesterol desmolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30 32" type="primary">CYP11A1</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22 29">A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(20R,22R)-20,22-dihydroxycholesterol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 4-methylpentanal + pregnenolone + 2 oxidized [adrenodoxin] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34343"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:1294"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16581"/>
            <dbReference type="ChEBI" id="CHEBI:17998"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:34344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(22R)-hydroxycholesterol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:34339"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:1294"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:67237"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:34340"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:34335"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:67237"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:34336"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:35739"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:16581"/>
            <dbReference type="ChEBI" id="CHEBI:17998"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:35740"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27 29">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 29">Lipid metabolism; C21-steroid hormone metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with FDX1/adrenodoxin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="29">Mitochondrion inner membrane</location>
            <topology evidence="29">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="29">Localizes to the matrix side of the mitochondrion inner membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 28">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.6" evidence="6 29"/>
    <dbReference type="AlphaFoldDB" id="A0A096NMQ3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014262"/>
    <dbReference type="Ensembl" id="ENSPANT00000003531.3">
        <property type="protein sequence ID" value="ENSPANP00000014262.2"/>
        <property type="gene ID" value="ENSPANG00000016014.3"/>
    </dbReference>
    <dbReference type="VGNC" id="VGNC:81868">
        <property type="gene designation" value="CYP11A1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158575"/>
    <dbReference type="HOGENOM" id="CLU_001570_28_4_1"/>
    <dbReference type="OMA" id="QVANYAM"/>
    <dbReference type="UniPathway" id="UPA00229"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016014">
        <property type="expression patterns" value="Expressed in adrenal medulla and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008386">
        <property type="term" value="F:cholesterol monooxygenase (side-chain-cleaving) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006700">
        <property type="term" value="P:C21-steroid hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006704">
        <property type="term" value="P:glucocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20643">
        <property type="entry name" value="CYP11A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000015">
        <property type="entry name" value="Cholesterol side-chain cleavage enzyme, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF3">
        <property type="entry name" value="CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 29" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="9 27 28" id="KW-0349">Heme</keyword>
    <keyword evidence="14 27 28" id="KW-0408">Iron</keyword>
    <keyword evidence="16 29" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 27 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 29" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15 28" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20 29" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="21 29" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="19 29" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="12 29" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" description="axial binding residue" evidence="27">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU364077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014262.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="VGNC" id="VGNC:81868"/>
        </source>
    </evidence>
    <sequence length="521" mass="60280" checksum="B7058F479CDD22B0" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNC5</accession>
    <name>A0A096NNC5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ubiquitin receptor ADRM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">110 kDa cell membrane glycoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Adhesion-regulating molecule 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Rpn13 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ADRM1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). Interacts with the proteasomal scaffolding protein PSMD1. Interacts with deubiquitinase UCHL5; this interaction activates the auto-inhibited UCHL5 by deoligomerizing it. Interacts with UBQLN2 and ubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904575.1">
        <property type="nucleotide sequence ID" value="XM_003904526.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214068.1">
        <property type="nucleotide sequence ID" value="XM_009215804.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNC5"/>
    <dbReference type="SMR" id="A0A096NNC5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014485"/>
    <dbReference type="Ensembl" id="ENSPANT00000006659.3">
        <property type="protein sequence ID" value="ENSPANP00000014485.1"/>
        <property type="gene ID" value="ENSPANG00000021463.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024714"/>
    <dbReference type="KEGG" id="panu:101024714"/>
    <dbReference type="CTD" id="11047"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013839"/>
    <dbReference type="HOGENOM" id="CLU_041798_2_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021463">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NNC5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="14">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="13">
        <location>
            <begin position="277"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="407" mass="42167" checksum="6C3880C76152C2CF" modified="2014-11-26" version="1">MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTAEEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUA3</accession>
    <name>A0A096NUA3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger and BTB domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZBTB14</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with ZBTB21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009190718.1">
        <property type="nucleotide sequence ID" value="XM_009192454.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017807076.1">
        <property type="nucleotide sequence ID" value="XM_017951587.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031514582.1">
        <property type="nucleotide sequence ID" value="XM_031658722.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031514583.1">
        <property type="nucleotide sequence ID" value="XM_031658723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUA3"/>
    <dbReference type="SMR" id="A0A096NUA3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016627"/>
    <dbReference type="Ensembl" id="ENSPANT00000023708.3">
        <property type="protein sequence ID" value="ENSPANP00000016627.1"/>
        <property type="gene ID" value="ENSPANG00000003128.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009405"/>
    <dbReference type="KEGG" id="panu:101009405"/>
    <dbReference type="CTD" id="7541"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158052"/>
    <dbReference type="HOGENOM" id="CLU_697455_0_0_1"/>
    <dbReference type="OMA" id="CIGCDYK"/>
    <dbReference type="OrthoDB" id="6425912at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003128">
        <property type="expression patterns" value="Expressed in axillary lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NUA3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003279">
        <property type="term" value="P:cardiac septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003170">
        <property type="term" value="P:heart valve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18204">
        <property type="entry name" value="BTB_POZ_ZBTB14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000147">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000316">
        <property type="entry name" value="Zinc finger and BTB domain-containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000762">
        <property type="entry name" value="Zinc finger and BTB domain-containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000766">
        <property type="entry name" value="Zinc finger and BTB domain-containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000054">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF27">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR KAISO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="17">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="449" mass="50956" checksum="B99F22E3B1D4E6CE" modified="2014-11-26" version="1">MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADTQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NVJ8</accession>
    <name>A0A096NVJ8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Potassium voltage-gated channel subfamily H member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">KCNH5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003901957.3">
        <property type="nucleotide sequence ID" value="XM_003901908.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NVJ8"/>
    <dbReference type="SMR" id="A0A096NVJ8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017073"/>
    <dbReference type="Ensembl" id="ENSPANT00000025622.3">
        <property type="protein sequence ID" value="ENSPANP00000017073.2"/>
        <property type="gene ID" value="ENSPANG00000019995.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101005388"/>
    <dbReference type="KEGG" id="panu:101005388"/>
    <dbReference type="CTD" id="27133"/>
    <dbReference type="GeneTree" id="ENSGT00940000156540"/>
    <dbReference type="HOGENOM" id="CLU_005746_3_1_1"/>
    <dbReference type="OMA" id="YTSREMM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019995">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 34 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NVJ8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000003">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000009">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000009">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000035">
        <property type="entry name" value="Potassium voltage-gated channel, subfamily H (Eag-related), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003949">
        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF533">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01464">
        <property type="entry name" value="EAGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="19">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="550"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="838"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017073.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="988" mass="111909" checksum="E27F3041029CB4FF" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWG8</accession>
    <name>A0A096NWG8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidoglycan recognition protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PGLYRP3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021779574.1">
        <property type="nucleotide sequence ID" value="XM_021923882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWG8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017396"/>
    <dbReference type="Ensembl" id="ENSPANT00000009619.3">
        <property type="protein sequence ID" value="ENSPANP00000017396.1"/>
        <property type="gene ID" value="ENSPANG00000026391.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001118"/>
    <dbReference type="KEGG" id="panu:101001118"/>
    <dbReference type="CTD" id="114771"/>
    <dbReference type="eggNOG" id="ENOG502S2KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162657"/>
    <dbReference type="HOGENOM" id="CLU_037559_1_0_1"/>
    <dbReference type="OMA" id="SVYTIGW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026391">
        <property type="expression patterns" value="Expressed in esophagus and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016019">
        <property type="term" value="F:peptidoglycan immune receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016045">
        <property type="term" value="P:detection of bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032827">
        <property type="term" value="P:negative regulation of natural killer cell differentiation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000004">
        <property type="entry name" value="Peptidoglycan recognition protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF12">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922908" evidence="13">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="15">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="15">
        <location>
            <begin position="179"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="14">
        <location>
            <begin position="189"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="341" mass="37650" checksum="6E4ACBFB46D988BE" modified="2014-11-26" version="1">MRMLPWLLAFSILGLQAWDTPTVVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQEQSICNQMLRGLQSHSIYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAFFGSKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPNIIKRSVWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHVQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLVGHSDVVSILSPGQALYNIISTWPHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXQ1</accession>
    <name>A0A096NXQ1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tigger transposable element derived 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TIGD2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031520466.1">
        <property type="nucleotide sequence ID" value="XM_031664606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXQ1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017852"/>
    <dbReference type="Ensembl" id="ENSPANT00000002974.3">
        <property type="protein sequence ID" value="ENSPANP00000017852.1"/>
        <property type="gene ID" value="ENSPANG00000017875.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023375"/>
    <dbReference type="KEGG" id="panu:101023375"/>
    <dbReference type="CTD" id="166815"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162273"/>
    <dbReference type="HOGENOM" id="CLU_018294_1_1_1"/>
    <dbReference type="OMA" id="QWFDSQS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017875">
        <property type="expression patterns" value="Expressed in liver and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF22">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="525" mass="59533" checksum="136C1DAF4EACFE33" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYA3</accession>
    <name>A0A096NYA3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Organic cation transporter-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC22A18</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021781102.2">
        <property type="nucleotide sequence ID" value="XM_021925410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYA3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018065"/>
    <dbReference type="Ensembl" id="ENSPANT00000014694.3">
        <property type="protein sequence ID" value="ENSPANP00000018065.3"/>
        <property type="gene ID" value="ENSPANG00000023336.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004965"/>
    <dbReference type="KEGG" id="panu:101004965"/>
    <dbReference type="CTD" id="5002"/>
    <dbReference type="eggNOG" id="ENOG502QT94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160333"/>
    <dbReference type="HOGENOM" id="CLU_001265_10_1_1"/>
    <dbReference type="OMA" id="RLMKYPR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023336">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NYA3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17331">
        <property type="entry name" value="MFS_SLC22A18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000297">
        <property type="entry name" value="Solute carrier family 22 member 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018065.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="424" mass="44817" checksum="C31948C48D41F15B" modified="2022-05-25" version="3">MQGAWAPRDQGQSPGRMSTLGRSSVILLTYVLAAIELTCLFMQFSVVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAILSFTCIPASTKGTKTDTQTPSPGGPRASVFDMKAIASLLRLPGVPRIFLVKVASNFPTGLFTVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEALLRASVLAFIAVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLTKAVSASDTGAMLGLCASVQPLLRTLGPTVGGFLYRSFGVPIFGHVQVAINVLVLLVLWRKPMPQRKDKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P055</accession>
    <name>A0A096P055_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 10">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UGP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="4 10"/>
    <dbReference type="RefSeq" id="XP_021780576.1">
        <property type="nucleotide sequence ID" value="XM_021924884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P055"/>
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        <property type="protein sequence ID" value="ENSPANP00000018730.3"/>
        <property type="gene ID" value="ENSPANG00000020689.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021917"/>
    <dbReference type="CTD" id="7360"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153464"/>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
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    <dbReference type="Bgee" id="ENSPANG00000020689">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P055">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
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    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="UGPase_euk"/>
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        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
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    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
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    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
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    <dbReference type="PIRSF" id="PIRSF000806">
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    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UTP</name>
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    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018730.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="508" mass="56966" checksum="6A5EE8A7817AA461" modified="2022-05-25" version="3">MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLLPVAKDVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNPKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P0V8</accession>
    <name>A0A096P0V8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sushi domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SUSD1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P0V8"/>
    <dbReference type="Ensembl" id="ENSPANT00000027374.3">
        <property type="protein sequence ID" value="ENSPANP00000018983.3"/>
        <property type="gene ID" value="ENSPANG00000025758.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013892"/>
    <dbReference type="HOGENOM" id="CLU_020797_0_0_1"/>
    <dbReference type="OMA" id="TCLRWQI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025758">
        <property type="expression patterns" value="Expressed in thymus and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P0V8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
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    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF5">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035299815" evidence="13">
        <location>
            <begin position="30"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
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    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
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    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018983.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="757" mass="84152" checksum="028582D771F7A4C0" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1F1</accession>
    <name>A0A096P1F1_PAPAN</name>
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        <submittedName>
            <fullName evidence="5">IZUMO family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IZUMO3</name>
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    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Izumo family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P1F1"/>
    <dbReference type="Ensembl" id="ENSPANT00000025997.3">
        <property type="protein sequence ID" value="ENSPANP00000019176.2"/>
        <property type="gene ID" value="ENSPANG00000025266.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S8ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017601"/>
    <dbReference type="HOGENOM" id="CLU_103188_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
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    <dbReference type="Bgee" id="ENSPANG00000025266">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029389">
        <property type="entry name" value="IZUMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36470">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36470:SF1">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15005">
        <property type="entry name" value="IZUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5014124481" evidence="4">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019176.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="233" mass="27207" checksum="B03A442B853B4305" modified="2018-02-28" version="2">MGDLWLFLLLPLSAFHGVKGCLECDPKFIEDVGSLLANLIPSEVPGQTQLLEWQIKEMISLSFKVSHSDKRLRVLAVQQVVKLRTWLKNEFYKLGNETWKGVFIFQGKLLEVRQNLESKLKELLKNFSEVVVVEGPILDCWMCLRMTNRCFKGEYCGDEDPRKAENREIALFLILLATVVILGSAVLLFHFCIFHRRKMKAIRRSLKEYLEKKLEELMGNIDEEEEKDFRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1X1</accession>
    <name>A0A096P1X1_PAPAN</name>
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        <submittedName>
            <fullName evidence="8">Growth arrest specific 1</fullName>
        </submittedName>
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        <name evidence="8" type="primary">GAS1</name>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
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                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
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                <person name="Kovar C.K."/>
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                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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                <person name="Scheel M.S."/>
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                <person name="Sisson I.S."/>
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                <person name="Thornton R.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P1X1"/>
    <dbReference type="SMR" id="A0A096P1X1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019346"/>
    <dbReference type="Ensembl" id="ENSPANT00000024901.3">
        <property type="protein sequence ID" value="ENSPANP00000019346.3"/>
        <property type="gene ID" value="ENSPANG00000024891.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001195"/>
    <dbReference type="HOGENOM" id="CLU_068697_1_0_1"/>
    <dbReference type="OMA" id="AMLQCQE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024891">
        <property type="expression patterns" value="Expressed in aorta and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of protein processing"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
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    <feature type="domain" description="GDNF/GAS1" evidence="7">
        <location>
            <begin position="193"/>
            <end position="270"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
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            <dbReference type="SMART" id="SM00907"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="372" mass="38603" checksum="63C4A83BAAD38580" modified="2022-05-25" version="3">MKTLMQEVGRTWTNFSTGSASAAPRASSPFPSSPGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPECSYAYNQYAEACAPVLAQHGGGDAPGAAAAAAAFPASAASFSSRWRCPSHCISALIQLNHTRRGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGAGGVMGCTEARRRCDRDSRCNLALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAALLNDCVCDGLERPICESVKENMARLCFGAELGNGPGSSGSDGGLDDYYDEDYDDEQRPGGAGGEQPLDDDDGVPHPPRPGSGAAAAGGRGDLPYGPGRRSSGGGGRSAPRGAWTPLASILLLLLGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P296</accession>
    <name>A0A096P296_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 protein epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YWHAE</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003912049.4"/>
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        <property type="gene ID" value="ENSPANG00000024608.3"/>
    </dbReference>
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    <dbReference type="KEGG" id="panu:101010193"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_058290_0_2_1"/>
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        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024608">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="6">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019471.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="255" mass="29174" checksum="07817CCBD1F75B26" modified="2018-02-28" version="2">MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3C4</accession>
    <name>A0A096P3C4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase Nek8</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Never in mitosis A-related kinase 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NEK8</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A096P3C4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019849"/>
    <dbReference type="Ensembl" id="ENSPANT00000021851.3">
        <property type="protein sequence ID" value="ENSPANP00000019849.3"/>
        <property type="gene ID" value="ENSPANG00000023428.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159297"/>
    <dbReference type="HOGENOM" id="CLU_000288_123_1_1"/>
    <dbReference type="OMA" id="CPQQVPV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023428">
        <property type="expression patterns" value="Expressed in cornea and 53 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097543">
        <property type="term" value="C:ciliary inversin compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035330">
        <property type="term" value="P:regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08220">
        <property type="entry name" value="STKc_Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000262">
        <property type="entry name" value="Serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000017">
        <property type="entry name" value="Serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000020">
        <property type="entry name" value="serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000243">
        <property type="entry name" value="serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051997">
        <property type="entry name" value="STK_NEK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044120">
        <property type="entry name" value="STKc_Nek8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535">
        <property type="entry name" value="PROTEIN CBG16200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="112"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="570"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="688"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="740"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019849.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="800" mass="86661" checksum="958C9DDF828C54B7" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P536</accession>
    <name>A0A096P536_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myopalladin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MYPN</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the myotilin/palladin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003903870.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009213098.2">
        <property type="nucleotide sequence ID" value="XM_009214834.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009213100.2">
        <property type="nucleotide sequence ID" value="XM_009214836.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017818487.2">
        <property type="nucleotide sequence ID" value="XM_017962998.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017818488.2">
        <property type="nucleotide sequence ID" value="XM_017962999.3"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000020461"/>
    <dbReference type="Ensembl" id="ENSPANT00000002919.3">
        <property type="protein sequence ID" value="ENSPANP00000020461.2"/>
        <property type="gene ID" value="ENSPANG00000022100.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004821"/>
    <dbReference type="KEGG" id="panu:101004821"/>
    <dbReference type="CTD" id="84665"/>
    <dbReference type="eggNOG" id="ENOG502QSRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153441"/>
    <dbReference type="HOGENOM" id="CLU_006487_2_0_1"/>
    <dbReference type="OMA" id="DEMDHKP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022100">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P536">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="myopalladin isoform X1"/>
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        <property type="entry name" value="palladin isoform X2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47633:SF13">
        <property type="entry name" value="MYOPALLADIN"/>
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        <property type="entry name" value="I-set"/>
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    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
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    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Immunoglobulin"/>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
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    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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            <end position="359"/>
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    <feature type="domain" description="Ig-like" evidence="16">
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    <feature type="domain" description="Ig-like" evidence="16">
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020461.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1320" mass="145081" checksum="BCB2B9784F8B7CE1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5I0</accession>
    <name>A0A096P5I0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KRT24</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003913029.2">
        <property type="nucleotide sequence ID" value="XM_003912980.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P5I0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020605"/>
    <dbReference type="Ensembl" id="ENSPANT00000007473.3">
        <property type="protein sequence ID" value="ENSPANP00000020605.2"/>
        <property type="gene ID" value="ENSPANG00000021622.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024054"/>
    <dbReference type="KEGG" id="panu:101024054"/>
    <dbReference type="CTD" id="192666"/>
    <dbReference type="eggNOG" id="ENOG502QTM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161783"/>
    <dbReference type="HOGENOM" id="CLU_012560_8_3_1"/>
    <dbReference type="OMA" id="SGSTNMG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021622">
        <property type="expression patterns" value="Expressed in cornea and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF207">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="140"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="248"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020605.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="525" mass="54979" checksum="ABF8DAF2B9E9946B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MU54</accession>
    <name>A0A0A0MU54_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
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        <property type="protein sequence ID" value="ENSPANP00000000687.3"/>
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        <property type="component" value="Chromosome 20"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="EFh_PEF_CPNS1_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calpain small subunit 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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    <dbReference type="PANTHER" id="PTHR46735:SF1">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0106">Calcium</keyword>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000687.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="276" mass="29326" checksum="2D8002AB2FAF3371" modified="2022-05-25" version="3">MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDLSLFLTPSHQSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MU64</accession>
    <name>A0A0A0MU64_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Lin-37 DREAM MuvB core complex component</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">LIN37</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031659618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MU64"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000813"/>
    <dbReference type="Ensembl" id="ENSPANT00000018544.3">
        <property type="protein sequence ID" value="ENSPANP00000000813.3"/>
        <property type="gene ID" value="ENSPANG00000017373.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012111"/>
    <dbReference type="CTD" id="55957"/>
    <dbReference type="eggNOG" id="ENOG502QV4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002748"/>
    <dbReference type="HOGENOM" id="CLU_090128_0_0_1"/>
    <dbReference type="OMA" id="SNVARWK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017373">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031523">
        <property type="term" value="C:Myb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045023">
        <property type="term" value="P:G0 to G1 transition"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010467">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
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        <property type="entry name" value="LIN37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336:SF3">
        <property type="entry name" value="PROTEIN LIN-37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000813.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="246" mass="28396" checksum="685315631B087E5D" modified="2022-05-25" version="3">MFPVKVKVEKSELEMAKARNQLDAVLQCLLEKSHMDRERLDEEAGKTPSDTHNKDCSIAATGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPSVRERECSPSSPLPPLPEDEEGSEVNNSKSRDVYKLPPPTPPGPPGDACRSRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MX77</accession>
    <name>A0A0A0MX77_PAPAN</name>
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        <submittedName>
            <fullName evidence="16">Zinc finger protein 226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF226</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021786853.2">
        <property type="nucleotide sequence ID" value="XM_021931161.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031515242.1">
        <property type="nucleotide sequence ID" value="XM_031659382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MX77"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011890"/>
    <dbReference type="Ensembl" id="ENSPANT00000005160.3">
        <property type="protein sequence ID" value="ENSPANP00000011890.3"/>
        <property type="gene ID" value="ENSPANG00000031282.2"/>
    </dbReference>
    <dbReference type="GeneID" id="103880118"/>
    <dbReference type="KEGG" id="panu:103880118"/>
    <dbReference type="CTD" id="7769"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162119"/>
    <dbReference type="HOGENOM" id="CLU_002678_17_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011697">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MX77">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003095">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000709">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000274">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001702">
        <property type="entry name" value="Zinc finger protein 224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002236">
        <property type="entry name" value="Zinc finger protein 226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002239">
        <property type="entry name" value="Zinc finger protein 226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002367">
        <property type="entry name" value="zinc finger protein 226 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001534">
        <property type="entry name" value="zinc finger protein 227 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000623">
        <property type="entry name" value="Zinc finger protein 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000022">
        <property type="entry name" value="zinc finger protein 383 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000015">
        <property type="entry name" value="Zinc finger protein 569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002331">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011890.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="803" mass="91954" checksum="46350765B4D5A7AF" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MXL2</accession>
    <name>A0A0A0MXL2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 family 4 subfamily F member 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">CYP4F22</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MXL2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018574"/>
    <dbReference type="Ensembl" id="ENSPANT00000014280.3">
        <property type="protein sequence ID" value="ENSPANP00000018574.3"/>
        <property type="gene ID" value="ENSPANG00000015625.3"/>
    </dbReference>
    <dbReference type="VGNC" id="VGNC:81861">
        <property type="gene designation" value="CYP4F22"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161507"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_1"/>
    <dbReference type="OMA" id="HEPNWQL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015625">
        <property type="expression patterns" value="Expressed in esophagus and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20679">
        <property type="entry name" value="CYP4F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF53">
        <property type="entry name" value="ULTRA-LONG-CHAIN FATTY ACID OMEGA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018574.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="VGNC" id="VGNC:81861"/>
        </source>
    </evidence>
    <sequence length="531" mass="62005" checksum="F83294A5EDE6DB00" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LJE3</accession>
    <name>A0A2I3LJE3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysosomal enzyme trafficking factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 251</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with GNPTAB; this interaction is important for proper localization of GNPTAB in Golgi stacks. Interacts with MBTPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LYSET family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LJE3"/>
    <dbReference type="Ensembl" id="ENSPANT00000048852.2">
        <property type="protein sequence ID" value="ENSPANP00000023557.1"/>
        <property type="gene ID" value="ENSPANG00000032474.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007473"/>
    <dbReference type="OMA" id="CIFPIYL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032474">
        <property type="expression patterns" value="Expressed in pancreas and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028024">
        <property type="entry name" value="LYSET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31925:SF1">
        <property type="entry name" value="LYSOSOMAL ENZYME TRAFFICKING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31925">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15190">
        <property type="entry name" value="TMEM251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="163" mass="19097" checksum="531678105482C0B5" modified="2018-02-28" version="1">EPDHWLFSDLSDQRVALRIYVAGTLGRHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQHPEEPLEGTTWTHSLKARLLSLPFWLWTITFLVPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LKH9</accession>
    <name>A0A2I3LKH9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sperm-associated antigen 16 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pf20 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPAG16</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with SPAG6 and STK36.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_017802386.1">
        <property type="nucleotide sequence ID" value="XM_017946897.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LKH9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000023938"/>
    <dbReference type="Ensembl" id="ENSPANT00000056064.2">
        <property type="protein sequence ID" value="ENSPANP00000023938.1"/>
        <property type="gene ID" value="ENSPANG00000011416.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000075"/>
    <dbReference type="CTD" id="79582"/>
    <dbReference type="GeneTree" id="ENSGT00940000155053"/>
    <dbReference type="OMA" id="VSDDETW"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011416">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LKH9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090660">
        <property type="term" value="P:cerebrospinal fluid circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120197">
        <property type="term" value="P:mucociliary clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000993">
        <property type="entry name" value="Sperm associated antigen 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000934">
        <property type="entry name" value="sperm-associated antigen 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001241">
        <property type="entry name" value="Sperm-associated antigen 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="631" mass="70818" checksum="6548D2F2E6A30719" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LM54</accession>
    <name>A0A2I3LM54_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger C2HC domain-containing protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZC2HC1A</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LM54"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024548"/>
    <dbReference type="Ensembl" id="ENSPANT00000055719.2">
        <property type="protein sequence ID" value="ENSPANP00000024548.2"/>
        <property type="gene ID" value="ENSPANG00000009231.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159419"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009231">
        <property type="expression patterns" value="Expressed in prostate gland and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LM54">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF25">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="319" mass="34438" checksum="15D293A856C295B4" modified="2022-05-25" version="2">QNGGVVQVGELLPCKICGRTFFPVALKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYDPDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQYKPPALKKSNSPGTASSGSSRLPQPSGTGKTVVGVPSGKVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYNESYIARPDGDCASSVNGGNIKGIEGNSPGNLPKFCHECGTKYPVEWAKFCCECGIRRMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LML4</accession>
    <name>A0A2I3LML4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbonic anhydrase</fullName>
            <ecNumber evidence="8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CA5B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>urea = cyanamide + H2O</text>
            <dbReference type="Rhea" id="RHEA:23056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16698"/>
            <dbReference type="EC" id="4.2.1.69"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_003917488.2">
        <property type="nucleotide sequence ID" value="XM_003917439.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809585.2">
        <property type="nucleotide sequence ID" value="XM_017954096.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809586.2">
        <property type="nucleotide sequence ID" value="XM_017954097.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809587.2">
        <property type="nucleotide sequence ID" value="XM_017954098.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809588.2">
        <property type="nucleotide sequence ID" value="XM_017954099.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809589.2">
        <property type="nucleotide sequence ID" value="XM_017954100.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809590.2">
        <property type="nucleotide sequence ID" value="XM_017954101.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017809591.2">
        <property type="nucleotide sequence ID" value="XM_017954102.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788734.2">
        <property type="nucleotide sequence ID" value="XM_021933042.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021788735.2">
        <property type="nucleotide sequence ID" value="XM_021933043.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031516372.1">
        <property type="nucleotide sequence ID" value="XM_031660512.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031516373.1">
        <property type="nucleotide sequence ID" value="XM_031660513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LML4"/>
    <dbReference type="Ensembl" id="ENSPANT00000041328.2">
        <property type="protein sequence ID" value="ENSPANP00000024674.2"/>
        <property type="gene ID" value="ENSPANG00000004636.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003738"/>
    <dbReference type="KEGG" id="panu:101003738"/>
    <dbReference type="CTD" id="11238"/>
    <dbReference type="GeneTree" id="ENSGT00940000156978"/>
    <dbReference type="HOGENOM" id="CLU_039326_2_1_1"/>
    <dbReference type="OMA" id="GESNDWG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018820">
        <property type="term" value="F:cyanamide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF25">
        <property type="entry name" value="CARBONIC ANHYDRASE 5B, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024674.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="317" mass="36480" checksum="FAEDEA59DB603677" modified="2022-05-25" version="1">MVVINSLRVILQASPGKLLWRKFQIPRFMPTRPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHIWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVKFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDTLVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVRAKSKPATSQATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LQ88</accession>
    <name>A0A2I3LQ88_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt-related transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RUNX1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003895569.3">
        <property type="nucleotide sequence ID" value="XM_003895520.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LQ88"/>
    <dbReference type="SMR" id="A0A2I3LQ88"/>
    <dbReference type="STRING" id="9555.ENSPANP00000025646"/>
    <dbReference type="Ensembl" id="ENSPANT00000037055.2">
        <property type="protein sequence ID" value="ENSPANP00000025646.1"/>
        <property type="gene ID" value="ENSPANG00000007357.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020650"/>
    <dbReference type="KEGG" id="panu:101020650"/>
    <dbReference type="CTD" id="861"/>
    <dbReference type="GeneTree" id="ENSGT00940000159255"/>
    <dbReference type="OMA" id="ECIHGMN"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007357">
        <property type="expression patterns" value="Expressed in thymus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LQ88">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016513">
        <property type="term" value="C:core-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002573">
        <property type="term" value="P:myeloid leukocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030854">
        <property type="term" value="P:positive regulation of granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000001">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.770.10:FF:000002">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.770.10">
        <property type="entry name" value="Signal Protein Aml-1b, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027384">
        <property type="entry name" value="Runx_central_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013711">
        <property type="entry name" value="RunxI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016554">
        <property type="entry name" value="TF_Runt-rel_RUNX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF40">
        <property type="entry name" value="RUNT-RELATED TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08504">
        <property type="entry name" value="RunxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009374">
        <property type="entry name" value="TF_Runt-rel_RUNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="9">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR009374-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="480" mass="51812" checksum="F8051BEABD12A994" modified="2018-02-28" version="1">MASDSIFESFPSYPQCFMRECILGMNPPRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPAARLEEAVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LQH5</accession>
    <name>A0A2I3LQH5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP binding cassette subfamily A member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ABCA8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000042757.2">
        <property type="protein sequence ID" value="ENSPANP00000025720.2"/>
        <property type="gene ID" value="ENSPANG00000020480.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162012"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020480">
        <property type="expression patterns" value="Expressed in olfactory bulb and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LQH5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001846">
        <property type="entry name" value="ATP binding cassette subfamily A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002668">
        <property type="entry name" value="ATP binding cassette subfamily A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="822"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1123"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="480"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1245"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025720.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1581" mass="179105" checksum="C5B6511B7D78162E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LR55</accession>
    <name>A0A2I3LR55_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Suppressor of tumorigenicity 7 protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ST7L</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017801363.1">
        <property type="nucleotide sequence ID" value="XM_017945874.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LR55"/>
    <dbReference type="Ensembl" id="ENSPANT00000056869.2">
        <property type="protein sequence ID" value="ENSPANP00000025961.1"/>
        <property type="gene ID" value="ENSPANG00000005529.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013011"/>
    <dbReference type="CTD" id="54879"/>
    <dbReference type="GeneTree" id="ENSGT00390000000873"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005529">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LR55">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF4">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 7 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="544" mass="61021" checksum="CEB4A85F5F338B4B" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LXX9</accession>
    <name>A0A2I3LXX9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TCF15</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003904979.1">
        <property type="nucleotide sequence ID" value="XM_003904930.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LXX9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000028299"/>
    <dbReference type="Ensembl" id="ENSPANT00000055682.2">
        <property type="protein sequence ID" value="ENSPANP00000028299.1"/>
        <property type="gene ID" value="ENSPANG00000030527.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101003302"/>
    <dbReference type="KEGG" id="panu:101003302"/>
    <dbReference type="CTD" id="6939"/>
    <dbReference type="GeneTree" id="ENSGT00940000161320"/>
    <dbReference type="OMA" id="HRTQNVN"/>
    <dbReference type="OrthoDB" id="6106870at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030527">
        <property type="expression patterns" value="Expressed in amygdala and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043583">
        <property type="term" value="P:ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045198">
        <property type="term" value="P:establishment of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060231">
        <property type="term" value="P:mesenchymal to epithelial transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048644">
        <property type="term" value="P:muscle organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902037">
        <property type="term" value="P:negative regulation of hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050884">
        <property type="term" value="P:neuromuscular process controlling posture"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048339">
        <property type="term" value="P:paraxial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000738">
        <property type="term" value="P:positive regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903053">
        <property type="term" value="P:regulation of extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11470">
        <property type="entry name" value="bHLH_TS_TCF15_paraxis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="198" mass="20834" checksum="B49548C4E8CF8B88" modified="2018-02-28" version="1">MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGLEAARRGPGPGGGRRAGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKSAVPTAAADGGRQPRSICTFCLSNQRKGGGRRDLGGGCLKVRGVAPLRGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LZH6</accession>
    <name>A0A2I3LZH6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Cytochrome c oxidase subunit 7C, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Cytochrome c oxidase polypeptide VIIc</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with RAB5IF.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017813408.1">
        <property type="nucleotide sequence ID" value="XM_017957919.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LZH6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000028867"/>
    <dbReference type="Ensembl" id="ENSPANT00000045040.2">
        <property type="protein sequence ID" value="ENSPANP00000028867.1"/>
        <property type="gene ID" value="ENSPANG00000034533.2"/>
    </dbReference>
    <dbReference type="GeneID" id="108585455"/>
    <dbReference type="KEGG" id="panu:108585455"/>
    <dbReference type="GeneTree" id="ENSGT00390000018086"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034533">
        <property type="expression patterns" value="Expressed in thymus and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00929">
        <property type="entry name" value="Cyt_c_Oxidase_VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="63" mass="7308" checksum="B608D7419A0902DF" modified="2018-02-28" version="1">MLGHSTRRFTTSVVRRSHYEEGPGKYLPFSVENKWALLVKMCLYFGSAFAAPFFIVRHQLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M041</accession>
    <name>A0A2I3M041_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclic AMP-dependent transcription factor ATF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATF2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds DNA as a dimer and can form a homodimer in the absence of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the bZIP family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_017946674.3"/>
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    <dbReference type="SMR" id="A0A2I3M041"/>
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        <property type="protein sequence ID" value="ENSPANP00000029098.2"/>
        <property type="gene ID" value="ENSPANG00000004806.3"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:H4 histone acetyltransferase complex"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029098.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="505" mass="54537" checksum="0190EEFAEC8891A7" modified="2022-05-25" version="2">MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M9M5</accession>
    <name>A0A2I3M9M5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M9M5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000032349"/>
    <dbReference type="Ensembl" id="ENSPANT00000035016.2">
        <property type="protein sequence ID" value="ENSPANP00000032349.2"/>
        <property type="gene ID" value="ENSPANG00000036128.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000475"/>
    <dbReference type="OMA" id="MQPYSAC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000036128">
        <property type="expression patterns" value="Expressed in smooth muscle tissue and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF27">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="141" mass="16292" checksum="9BA408D1953A833F" modified="2022-05-25" version="2">MAEVEQKLTFRKFTYRGVDSDQQLDTSHQQLMQPYSACQRRKLNPGLRRKQHSLPKRLGEATKPEVEKPEVVKTHLGDMIIPPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYEPVRHCRPDLRATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MCM0</accession>
    <name>A0A2I3MCM0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031509183.1">
        <property type="nucleotide sequence ID" value="XM_031653323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MCM0"/>
    <dbReference type="SMR" id="A0A2I3MCM0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033456"/>
    <dbReference type="Ensembl" id="ENSPANT00000038971.2">
        <property type="protein sequence ID" value="ENSPANP00000033456.2"/>
        <property type="gene ID" value="ENSPANG00000032114.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101020150"/>
    <dbReference type="KEGG" id="panu:101020150"/>
    <dbReference type="CTD" id="6157"/>
    <dbReference type="GeneTree" id="ENSGT00390000005534"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032114">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000024">
        <property type="entry name" value="RPL27A isoform 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="9">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033456.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="148" mass="16559" checksum="CB57C4D1848E6106" modified="2022-05-25" version="2">MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPGYFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGACVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MJ33</accession>
    <name>A0A2I3MJ33_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALDOC</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MJ33"/>
    <dbReference type="Ensembl" id="ENSPANT00000033528.2">
        <property type="protein sequence ID" value="ENSPANP00000035743.1"/>
        <property type="gene ID" value="ENSPANG00000023455.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182987"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023455">
        <property type="expression patterns" value="Expressed in cerebellum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MJ33">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000205">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000208">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="336" mass="36247" checksum="E278502931587D3B" modified="2018-02-28" version="1">MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTDGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILDNANVLARYASICQQVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASLNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIANHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MNR4</accession>
    <name>A0A2I3MNR4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IDH3B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009214717.1">
        <property type="nucleotide sequence ID" value="XM_009216453.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MNR4"/>
    <dbReference type="SMR" id="A0A2I3MNR4"/>
    <dbReference type="Ensembl" id="ENSPANT00000051380.2">
        <property type="protein sequence ID" value="ENSPANP00000037389.2"/>
        <property type="gene ID" value="ENSPANG00000023587.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020470"/>
    <dbReference type="KEGG" id="panu:101020470"/>
    <dbReference type="CTD" id="3420"/>
    <dbReference type="GeneTree" id="ENSGT00950000182989"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023587">
        <property type="expression patterns" value="Expressed in heart and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MNR4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="9">
        <location>
            <begin position="50"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037389.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="385" mass="42255" checksum="1730F0E614595EB3" modified="2022-05-25" version="2">MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSNMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLHPHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MZ07</accession>
    <name>A0A2I3MZ07_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger matrin-type protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZMAT2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing as a component of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome B complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031522348.1">
        <property type="nucleotide sequence ID" value="XM_031666488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MZ07"/>
    <dbReference type="SMR" id="A0A2I3MZ07"/>
    <dbReference type="STRING" id="9555.ENSPANP00000040846"/>
    <dbReference type="Ensembl" id="ENSPANT00000057584.2">
        <property type="protein sequence ID" value="ENSPANP00000040846.2"/>
        <property type="gene ID" value="ENSPANG00000032021.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101003500"/>
    <dbReference type="KEGG" id="panu:101003500"/>
    <dbReference type="CTD" id="153527"/>
    <dbReference type="GeneTree" id="ENSGT00390000010712"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032021">
        <property type="expression patterns" value="Expressed in putamen and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000282">
        <property type="entry name" value="Zinc finger, matrin-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="11">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000040846.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="199" mass="23612" checksum="EF419358B7977E36" modified="2022-05-25" version="2">MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NA81</accession>
    <name>A0A2I3NA81_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Myelin regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Myelin gene regulatory factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">MYRF</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homotrimer. Interacts (via C-terminal region) with TMEM98; the interaction inhibits MYRF self-cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MRF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017803810.1">
        <property type="nucleotide sequence ID" value="XM_017948321.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NA81"/>
    <dbReference type="STRING" id="9555.ENSPANP00000044782"/>
    <dbReference type="Ensembl" id="ENSPANT00000041660.2">
        <property type="protein sequence ID" value="ENSPANP00000044782.2"/>
        <property type="gene ID" value="ENSPANG00000013413.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025800"/>
    <dbReference type="KEGG" id="panu:101025800"/>
    <dbReference type="CTD" id="745"/>
    <dbReference type="GeneTree" id="ENSGT00530000063626"/>
    <dbReference type="OMA" id="LCSSYPC"/>
    <dbReference type="OrthoDB" id="27041at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013413">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NA81">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032286">
        <property type="term" value="P:central nervous system myelin maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031643">
        <property type="term" value="P:positive regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10144">
        <property type="entry name" value="Peptidase_S74_CIMCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000001">
        <property type="entry name" value="Myelin gene regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000011">
        <property type="entry name" value="Myelin regulatory factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF16">
        <property type="entry name" value="MYELIN REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15 27" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NDT80" evidence="29">
        <location>
            <begin position="250"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="30">
        <location>
            <begin position="587"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="27">
        <location>
            <begin position="250"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="284"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="722"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="891"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="965"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="989"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00055922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00057438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00060149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00064388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00075238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044782.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124366" checksum="A232CB9883E62DA6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NFI8</accession>
    <name>A0A2I3NFI8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Myelin-oligodendrocyte glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MOG</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897324.1">
        <property type="nucleotide sequence ID" value="XM_003897275.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NFI8"/>
    <dbReference type="SMR" id="A0A2I3NFI8"/>
    <dbReference type="Ensembl" id="ENSPANT00000055684.2">
        <property type="protein sequence ID" value="ENSPANP00000046747.1"/>
        <property type="gene ID" value="ENSPANG00000004308.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011869"/>
    <dbReference type="KEGG" id="panu:101011869"/>
    <dbReference type="CTD" id="4340"/>
    <dbReference type="GeneTree" id="ENSGT00940000153527"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004308">
        <property type="expression patterns" value="Expressed in lateral globus pallidus and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05713">
        <property type="entry name" value="IgV_MOG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000183">
        <property type="entry name" value="Myelin-oligodendrocyte glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016663">
        <property type="entry name" value="Myelin-oligodendrocyte_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF71">
        <property type="entry name" value="MYELIN-OLIGODENDROCYTE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016522">
        <property type="entry name" value="MOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014151991" description="Myelin-oligodendrocyte glycoprotein" evidence="14">
        <location>
            <begin position="30"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR016522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="247" mass="28208" checksum="7058C48E3A98C393" modified="2018-02-28" version="1">MASLSRPSLPSCLCSFLLLLLLQVSSSYAGQFRVIGPRQPIRALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGRDQDGEQAPEYRGRTELLKDAIGEGKVTLRIRNVRFSDEGGFTCFFRDHSYQEEAAIELKVEDPFYWVSPAVLVLLAVLPVLLLQITVGLVFLCLQYRLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFLEELRNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NHR1</accession>
    <name>A0A2I3NHR1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kallikrein related peptidase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KLK14</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3NHR1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000047386"/>
    <dbReference type="Ensembl" id="ENSPANT00000043474.2">
        <property type="protein sequence ID" value="ENSPANP00000047386.1"/>
        <property type="gene ID" value="ENSPANG00000004037.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230389"/>
    <dbReference type="OMA" id="CKYQTWI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004037">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NHR1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070684">
        <property type="term" value="P:seminal clot liquefaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000021">
        <property type="entry name" value="Kallikrein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000010">
        <property type="entry name" value="Kallikrein related peptidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF48">
        <property type="entry name" value="KALLIKREIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014157558" evidence="7">
        <location>
            <begin position="29"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="41"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000047386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="267" mass="29105" checksum="BD710185472E5233" modified="2018-02-28" version="1">MSLRALGSGTWPSAPKMFLLLTALQVLAIDMTRSQEDENKIIGGYTCTRSSQPWQAALLAGPGRRFLCGGALLSDQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHENDLMLLRLQQPARIGRAVRPTEVAQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYSKAITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZW6</accession>
    <name>A0A8I5MZW6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PPP1R14C</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Inhibitor of PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021793421.2">
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        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Phosphatase 1, regulatory (Inhibitor) subunit 14C"/>
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        <property type="entry name" value="CPI-17"/>
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        <property type="entry name" value="CPI-17_sf"/>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
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        <property type="entry name" value="PP1_inhibitor"/>
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        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
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    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 5" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        <source>
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        <source>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF154">
        <property type="entry name" value="PROTEIN-SERINE_THREONINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="F138DOMAIN"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="121" mass="13165" checksum="3D61B6C42ACDB09D" modified="2022-05-25" version="1">MLKGLTLLPRLECSDTISAHCSFNLPGSGDPPTLASQVAETTSSCHRTQVIFCLCFVDTRSHYVAQAGLELLSLSNEPTLASQSAGITGVCHCTQPQLFFWSVFIEGYSVPGTVRDNRQHY</sequence>
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    <accession>A0A8I5N1M5</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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            <taxon>Cercopithecinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
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                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
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                <person name="Pham C.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035227325" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="150"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052932.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="175" mass="18724" checksum="52784020D1AE53B3" modified="2022-05-25" version="1">MAATSLMSVLAAWLLQPAHSCCLPPRGVPNEAVIISGRQLAQQIKQKVRQEVEEWAGERVRGQGVALCCPCVLSLLCGEQVEEGVGGSPPPASSLSCSPRSCSPRSGSRRPRVGLPGPAWPLHKRVGFQASPSQLPGTHHPPRGRGVSGRRRGLFDCGFQTHFPARFGRQAGFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N2G9</accession>
    <name>A0A8I5N2G9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N2G9"/>
    <dbReference type="Ensembl" id="ENSPANT00000077993.1">
        <property type="protein sequence ID" value="ENSPANP00000053815.1"/>
        <property type="gene ID" value="ENSPANG00000044939.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00690000102286"/>
    <dbReference type="OMA" id="CIVNRIL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd09851">
        <property type="entry name" value="HTLV-1-like_HR1-HR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF73">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199585" evidence="3">
        <location>
            <begin position="17"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="557" mass="62401" checksum="19BC8F5FC997AEBF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N425</accession>
    <name>A0A8I5N425_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AMSH-like protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">STAM-binding protein-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STAMBPL1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N425"/>
    <dbReference type="Ensembl" id="ENSPANT00000077249.1">
        <property type="protein sequence ID" value="ENSPANP00000054943.1"/>
        <property type="gene ID" value="ENSPANG00000021744.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153710"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000012">
        <property type="entry name" value="AMSH-like protease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000010">
        <property type="entry name" value="AMSH-like protease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF7">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="15">
        <location>
            <begin position="269"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="436" mass="49762" checksum="20A474081CA44E9E" modified="2022-05-25" version="1">MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCAVLPKDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDVENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSHFFLPLCEEGRVLLPFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N503</accession>
    <name>A0A8I5N503_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein 697</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF697</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">RNA-interacting protein with a high number of miRNA targets. Acts as a damage-induced regulator of muscle remodeling by mediating the interferon gamma response in muscle cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N503"/>
    <dbReference type="Ensembl" id="ENSPANT00000070045.1">
        <property type="protein sequence ID" value="ENSPANP00000054197.1"/>
        <property type="gene ID" value="ENSPANG00000018117.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00820000127150"/>
    <dbReference type="OMA" id="EDKQGVC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000711">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001035">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001076">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000320">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF467">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="672" mass="75021" checksum="67E641E178A7606B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8I3</accession>
    <name>A0A8I5N8I3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8I3"/>
    <dbReference type="Ensembl" id="ENSPANT00000061821.1">
        <property type="protein sequence ID" value="ENSPANP00000056033.1"/>
        <property type="gene ID" value="ENSPANG00000040513.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="RWDYRHL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266262" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10474" checksum="F9ED0EDCD3C5C72B" modified="2022-05-25" version="1">MLLLLLSLLIFIIILRWSLALSRCVIQAGVQWHDLGSLQPPSPGFKQFSCLSLLSRWDYRHLPPHPANFCIFGRDRVSPCWSGWSQTPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8R7</accession>
    <name>A0A8I5N8R7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">5', 3'-nucleotidase, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NT5C</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003913457.1">
        <property type="nucleotide sequence ID" value="XM_003913408.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8R7"/>
    <dbReference type="SMR" id="A0A8I5N8R7"/>
    <dbReference type="Ensembl" id="ENSPANT00000067440.1">
        <property type="protein sequence ID" value="ENSPANP00000057252.1"/>
        <property type="gene ID" value="ENSPANG00000041048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025713"/>
    <dbReference type="KEGG" id="panu:101025713"/>
    <dbReference type="CTD" id="30833"/>
    <dbReference type="GeneTree" id="ENSGT00390000011596"/>
    <dbReference type="OMA" id="MLHMQDT"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019103">
        <property type="term" value="F:pyrimidine nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009223">
        <property type="term" value="P:pyrimidine deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02587">
        <property type="entry name" value="HAD_5-3dNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.40:FF:000001">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase, cytosolic type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000133">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase, cytosolic type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.40">
        <property type="entry name" value="Deoxyribonucleotidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16504">
        <property type="entry name" value="5'(3')-DEOXYRIBONUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16504:SF5">
        <property type="entry name" value="5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01145">
        <property type="entry name" value="C1.2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01126">
        <property type="entry name" value="C1.2:_Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="201" mass="23487" checksum="D8508FFD2283DECA" modified="2022-05-25" version="1">MARRLRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADKVASVYEAPGFFLDLEPIPGALDAVREMNDLPDTEVFICTSPLLKYDHCVGEKYRWVEQHLGPQFVERIILTRDKTVVLGDLLIDDKDTIRGDEETPRWEHILFTCCHNRHLVLPPTKRRLLSWSDNWREILDSKRGAAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NB31</accession>
    <name>A0A8I5NB31_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NB31"/>
    <dbReference type="Ensembl" id="ENSPANT00000078234.1">
        <property type="protein sequence ID" value="ENSPANP00000058549.1"/>
        <property type="gene ID" value="ENSPANG00000044889.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166143"/>
    <dbReference type="OMA" id="CHHRQLI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF154">
        <property type="entry name" value="PROTEIN-SERINE_THREONINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035205342" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8094" checksum="405D8BF39AAFEDD6" modified="2022-05-25" version="1">MFCFVLFCFLRQGLTLSASLECSGAIMAHCSLNLLGSSDPPTSASQVAGTTGVYHHAQLLFKFFHKIFPNKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NB54</accession>
    <name>A0A8I5NB54_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NB54"/>
    <dbReference type="Ensembl" id="ENSPANT00000077175.1">
        <property type="protein sequence ID" value="ENSPANP00000057413.1"/>
        <property type="gene ID" value="ENSPANG00000039982.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
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    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057413.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="116" mass="12745" checksum="1AC6DE5FCE97CDF6" modified="2022-05-25" version="1">LSSSISLSSDYHPSPRLLQSCLLSFLARHSLSSPIYSPQCIESNLFLFFFFFFLRRSLALSPRLECSGAISAHCKLRPPGSRHSPASASQVAGTTGARYRARLVFCIFSRDGVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NE39</accession>
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        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein 19</fullName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Perez Y.P."/>
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                <person name="Simmons D.S."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="6">May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.</text>
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    <comment type="subcellular location">
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            <location evidence="1">Cytoplasm</location>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
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            <begin position="751"/>
            <end position="810"/>
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    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="827"/>
            <end position="886"/>
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    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="917"/>
            <end position="976"/>
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    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="274"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="305"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="653"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="1"/>
            <end position="22"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="36"/>
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            <begin position="236"/>
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            <begin position="566"/>
            <end position="575"/>
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            <begin position="615"/>
            <end position="630"/>
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    </feature>
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            <begin position="644"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00056771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060181.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114535" checksum="B2D7BD2136A98FD3" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFU5</accession>
    <name>A0A8I5NFU5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OR8B4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NFU5"/>
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        <property type="protein sequence ID" value="ENSPANP00000057532.1"/>
        <property type="gene ID" value="ENSPANG00000050908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222320"/>
    <dbReference type="OMA" id="MDQGKFA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15405">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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            <dbReference type="RuleBase" id="RU000688"/>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057532.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="309" mass="34363" checksum="347AAFC00BF89803" modified="2022-05-25" version="1">MTLRNSSSVTEFILVGLSEQPELQLPLFLLFLGIYVLTVVGNLGLITLIGINPSLHTPMYFFLFNLSFIDLCYSCVFTPKMLNDFVSESIISYVGCMTQLFFFCFFVNSECYVLVSMAYDRYMAICNPLLYMVSMSPRVCFLLMFGSYVVGFAGAMAHTGSMLRLSFCDSNVIAHYLCEVLPLLQLSCTSTHINELVFFIVVGVIIMLSSLSIVISYALILSNILRIPSAEGRSKAFSTCSSHIIAVALFFGSGAFTYFTASFPSSVNHGRFASVFYTNVVPMLNPLIYSLRNKDVKLALGKTLKRVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGZ7</accession>
    <name>A0A8I5NGZ7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGZ7"/>
    <dbReference type="Ensembl" id="ENSPANT00000079241.1">
        <property type="protein sequence ID" value="ENSPANP00000051367.1"/>
        <property type="gene ID" value="ENSPANG00000037659.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005563"/>
    <dbReference type="OMA" id="VEIYCPY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="238" mass="25507" checksum="2309E6EDB8EA39F8" modified="2022-05-25" version="1">MSWLEENVRAVLQTVDAGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPERYLPPPSSHLPAPTSHLLPSTSLLPSPSFHLPPSTSLLLPLTSPPTSLLPPPTLLLLPLTSPPSSHLPPPTSQLPPSSSQLPPPTSHLPPPPPPPPSQLPPRCSHLAAPTSHLPASTFQFPAPSSFLPPPLPPPTSQLPPRCSQLPPPSSLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NI88</accession>
    <name>A0A8I5NI88_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Trem-like transcript 2 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Triggering receptor expressed on myeloid cells-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TREML2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with CD276 and this interaction enhances T-cell activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003897637.2">
        <property type="nucleotide sequence ID" value="XM_003897588.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NI88"/>
    <dbReference type="Ensembl" id="ENSPANT00000063491.1">
        <property type="protein sequence ID" value="ENSPANP00000057299.1"/>
        <property type="gene ID" value="ENSPANG00000048231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101024412"/>
    <dbReference type="KEGG" id="panu:101024412"/>
    <dbReference type="CTD" id="79865"/>
    <dbReference type="GeneTree" id="ENSGT00940000153835"/>
    <dbReference type="OMA" id="YPLMGFQ"/>
    <dbReference type="OrthoDB" id="8920197at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001672">
        <property type="entry name" value="Triggering receptor expressed on myeloid cells like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052314">
        <property type="entry name" value="Immune_rcpt_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16423:SF3">
        <property type="entry name" value="TREM-LIKE TRANSCRIPT 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16423">
        <property type="entry name" value="TREM-LIKE TRANSCRIPT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="250"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="384" mass="41797" checksum="17FC9091941F22CA" modified="2022-05-25" version="1">MGSMNPCGWLEAVGPTLPHFPKWAASLLEPQVLPWQAQVAHPVSGGPSPWISRPDTDQLDGTMAPAFLLLLLLLLWPQGCVSGPSADSVYTKVRLLEGETLSVQCSYKGYKSRMDGKVWCKVRKKKCELGFARVWVKGPRYLLQDDAQAKVVNITMVALRLQDSGRYWCMRNTSGTLYPLMGIQLDVSPAPKTERNTPFTHLANILKSGTVTTGQAPTSGPDAPFTTGVTMFTPGLLTLPRLLASTRPASKRGCSFTATSTTSQGPRRTTGSQTVTASPSNARDSSAGPESISTKSGHLSTRSPTTGLCLTSRSLLNRLPSIPSIRPQEVYSTVLVVLTLLVLMLIMVYGFWKKRYMASYSMCSDPSRGDPPRRPEPHVEVCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NIV4</accession>
    <name>A0A8I5NIV4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger and BTB domain containing 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZBTB34</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIV4"/>
    <dbReference type="Ensembl" id="ENSPANT00000070367.1">
        <property type="protein sequence ID" value="ENSPANP00000055210.1"/>
        <property type="gene ID" value="ENSPANG00000024819.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159944"/>
    <dbReference type="OMA" id="MVSNTGY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="FunFam" id="3.30.710.10:FF:000009">
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    <dbReference type="FunFam" id="3.30.160.60:FF:000364">
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055210.1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8I5NIY5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NIY5"/>
    <dbReference type="Ensembl" id="ENSPANT00000075187.1">
        <property type="protein sequence ID" value="ENSPANP00000049451.1"/>
        <property type="gene ID" value="ENSPANG00000051236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="139" mass="15492" checksum="9D6553C06FB3EE21" modified="2022-05-25" version="1">GQCFKGLWSLKTKWDNGEQLSSGTNVNAPRTGQFGVQWRNLGSLQLPPPGFKRVSCLSLLSSWDHRRTPPRAANLGIFGRDGISLCWPGWSQTPYLSRSTCLGLPMCWDYRHEPPCLADPPTLSTEYYLSFMAALAPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NK75</accession>
    <name>A0A8I5NK75_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NK75"/>
    <dbReference type="Ensembl" id="ENSPANT00000061642.1">
        <property type="protein sequence ID" value="ENSPANP00000053097.1"/>
        <property type="gene ID" value="ENSPANG00000043046.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF135">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="264" mass="30192" checksum="DCF2790D396FF2DC" modified="2022-05-25" version="1">MVLVGFRHEMRISSPETLRKGDEEQWEGGESKTGPEAKEQTPHLSCGSSSWRWNKPLCVGNSSQQMRYSEDAHDVSRNEYHLEKEQIQQDPFFFPLKNQANFSAILIYLLRKKVFILRSWQYHFFIIIIIIIIIIIINHDHHLFFFLFFFLRRSLSLSPRLECSGTISAHCNLRLPGSRDSPASAYQVVGITGVHHHARLIFIHLIETGFHHVGQAGLELPTWCDLPALASQNAGIKGVSHCMPSQTPKFSLSILALTILRLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLE2</accession>
    <name>A0A8I5NLE2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Helicase-like transcription factor</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">RING-type E3 ubiquitin transferase HLTF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Sucrose nonfermenting protein 2-like 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="primary">HLTF</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 39">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003895024.2">
        <property type="nucleotide sequence ID" value="XM_003894975.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021790446.1">
        <property type="nucleotide sequence ID" value="XM_021934754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLE2"/>
    <dbReference type="Ensembl" id="ENSPANT00000074158.1">
        <property type="protein sequence ID" value="ENSPANP00000050795.1"/>
        <property type="gene ID" value="ENSPANG00000009264.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002190"/>
    <dbReference type="KEGG" id="panu:101002190"/>
    <dbReference type="CTD" id="6596"/>
    <dbReference type="GeneTree" id="ENSGT00910000144305"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEXHc_HLTF1_SMARC3"/>
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        <property type="entry name" value="RING-HC_HLTF"/>
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        <property type="entry name" value="SF2_C_SNF"/>
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        <property type="entry name" value="helicase-like transcription factor isoform X1"/>
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        <property type="entry name" value="helicase-like transcription factor isoform X2"/>
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        <property type="entry name" value="helicase-like transcription factor isoform X3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="HIRAN"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
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    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
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    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
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        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
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        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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        <property type="entry name" value="ZF_RING_1"/>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24" id="KW-0010">Activator</keyword>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0347">Helicase</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
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    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="25" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="19" id="KW-0862">Zinc</keyword>
    <keyword evidence="15 32" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="435"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="36">
        <location>
            <begin position="837"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="341"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00074454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00078948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00079539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00079572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1009" mass="113697" checksum="22AA13E2104C4B12" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NPP3</accession>
    <name>A0A8I5NPP3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium calcium-activated channel subfamily M regulatory beta subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NPP3"/>
    <dbReference type="Ensembl" id="ENSPANT00000079385.1">
        <property type="protein sequence ID" value="ENSPANP00000055557.1"/>
        <property type="gene ID" value="ENSPANG00000044255.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183039"/>
    <dbReference type="OMA" id="WRPRVQE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003930">
        <property type="entry name" value="K_chnl_Ca-activ_BK_bsu"/>
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    <dbReference type="PANTHER" id="PTHR10258">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258:SF3">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03185">
        <property type="entry name" value="CaKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="99"/>
            <end position="115"/>
        </location>
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            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
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            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47176" checksum="126417EDE54A6488" modified="2022-05-25" version="1">AKSILIFHLGRPSKGTQGRFRLQVAAVACARQLLAQRRRPRAGRGEAGRGGRARVAGGRGGAEPPPARGSPRARPSSGTPSVGAAAGRVRGEAASGRWRQRDTRREEAGWGRRGECGGGGWQGALEAGADRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGRGERASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NR26</accession>
    <name>A0A8I5NR26_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eutheria</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NR26"/>
    <dbReference type="Ensembl" id="ENSPANT00000073614.1">
        <property type="protein sequence ID" value="ENSPANP00000053354.1"/>
        <property type="gene ID" value="ENSPANG00000040457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00620000089388"/>
    <dbReference type="OMA" id="PRAYHEH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="126" mass="13631" checksum="F19C9B855463BC85" modified="2022-05-25" version="1">MSSGEGAAHNLEEVRRQNLPRPNPPRGLNPKGEGREKGVGGESKRPRAYHEHGDPGGQRVEEHGGHGAAVLRARVGLAVGAVVAEEALHVHGERVRILEVVRQHHRPCHDHHLEIEHAAGILMAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NR78</accession>
    <name>A0A8I5NR78_PAPAN</name>
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        <recommendedName>
            <fullName evidence="12">Tropomyosin 4</fullName>
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    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NR78"/>
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        <property type="protein sequence ID" value="ENSPANP00000056445.1"/>
        <property type="gene ID" value="ENSPANG00000041315.1"/>
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    <dbReference type="OMA" id="CMKFFLL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24330" checksum="DA0E7F62DC60E336" modified="2022-05-25" version="1">NQHEYNSTERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHVAEEADRKYEEVARKLVILEGEVERAEERAEVSELKCGDPEKELKNVTNNLKSLEAASKKYSEKEDTYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NR85</accession>
    <name>A0A8I5NR85_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="3">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HAO1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NR85"/>
    <dbReference type="Ensembl" id="ENSPANT00000070399.1">
        <property type="protein sequence ID" value="ENSPANP00000051965.1"/>
        <property type="gene ID" value="ENSPANG00000040519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018717"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047969">
        <property type="term" value="F:glyoxylate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046296">
        <property type="term" value="P:glycolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 12" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="291"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="380" mass="42227" checksum="54158680A30FDB48" modified="2022-05-25" version="1">MLPRLVCINDYEQHAKSVLPKSIYDYYRSGANDEETLADNVAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVQQAEKTGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLMSLKQWFLNCKLRFKALEMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NSY2</accession>
    <name>A0A8I5NSY2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSY2"/>
    <dbReference type="Ensembl" id="ENSPANT00000067556.1">
        <property type="protein sequence ID" value="ENSPANP00000052962.1"/>
        <property type="gene ID" value="ENSPANG00000050821.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="OMA" id="IFILYID"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="116" mass="13028" checksum="87B57EBF6D58625E" modified="2022-05-25" version="1">MKDCAFLISTYLFETESLSRRLGYSSTIIAHCNLELLGSSDPLASAFQVAETTSVYHDAQLILKFFVETESCYVAQAGLQLLASRDYPILAFQSTEISGISHSSWPLKTLLKWMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU14</accession>
    <name>A0A8I5NU14_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="17">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PLCD1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Binds phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with TGM2.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU14"/>
    <dbReference type="Ensembl" id="ENSPANT00000075754.1">
        <property type="protein sequence ID" value="ENSPANP00000058672.1"/>
        <property type="gene ID" value="ENSPANG00000024753.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158392"/>
    <dbReference type="OMA" id="HWQREMS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141212">
        <property type="term" value="P:phospholipase C/protein kinase C signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16217">
        <property type="entry name" value="EFh_PI-PLCdelta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13363">
        <property type="entry name" value="PH_PLC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08593">
        <property type="entry name" value="PI-PLCc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000071">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000144">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000088">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000018">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="PI-PLC-X"/>
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        <property type="entry name" value="PLCXc"/>
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        <property type="entry name" value="PLCYc"/>
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        <property type="entry name" value="PLC-like phosphodiesterases"/>
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        <property type="entry name" value="EF_HAND_1"/>
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        <property type="entry name" value="EF_HAND_2"/>
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        <property type="entry name" value="PH_DOMAIN"/>
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        <property type="entry name" value="PIPLC_X_DOMAIN"/>
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    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
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    <keyword evidence="8 16" id="KW-0325">Glycoprotein</keyword>
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            <begin position="161"/>
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            <position position="333"/>
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            <name>Ca(2+)</name>
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        <location>
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            <position position="214"/>
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    <sequence length="781" mass="88581" checksum="11F12C526B9C5725" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUM6</accession>
    <name>A0A8I5NUM6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NUM6"/>
    <dbReference type="Ensembl" id="ENSPANT00000065276.1">
        <property type="protein sequence ID" value="ENSPANP00000056186.1"/>
        <property type="gene ID" value="ENSPANG00000045992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="173" mass="19428" checksum="2FE5BAC4527E7F0C" modified="2022-05-25" version="1">MQFTQASSLDIQCNDCETETQTTCSVEVMIMIRCVYSFVMKKGNTIFLAFDTLLSRFFFLFFLRGSLTLSPRLECSGAILAHCKLRLPGSRHSPASASRVAGTTGARHHTWLIFCIFSRDGVSPCQPGWSQSPHLVIRPPQPPKVLGPMQYVFFCVCPRLFTMTSVKFIHIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NUZ3</accession>
    <name>A0A8I5NUZ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Stabilin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">STAB2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000083923.1">
        <property type="protein sequence ID" value="ENSPANP00000056594.1"/>
        <property type="gene ID" value="ENSPANG00000021932.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156566"/>
    <dbReference type="OMA" id="NNKSEMW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030169">
        <property type="term" value="F:low-density lipoprotein particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03515">
        <property type="entry name" value="Link_domain_TSG_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000001">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000040">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000278">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000410">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000448">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000470">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000708">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000005">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000016">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000017">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000018">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000020">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000021">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056806">
        <property type="entry name" value="EGF_STAB1-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24038">
        <property type="entry name" value="STABILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24038:SF0">
        <property type="entry name" value="STABILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24887">
        <property type="entry name" value="EGF_STAB1-2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 20" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="17" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035238910" description="Stabilin-2" evidence="23">
        <location>
            <begin position="21"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2459"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="25">
        <location>
            <begin position="370"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="25">
        <location>
            <begin position="514"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="735"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="825"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="866"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="909"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="25">
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    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1373"/>
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    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1398"/>
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    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1417"/>
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    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1435"/>
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    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1987"/>
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    <feature type="disulfide bond" evidence="20">
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            <begin position="2031"/>
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        <location>
            <begin position="2219"/>
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    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="2243"/>
            <end position="2264"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073208"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079817"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
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        <source>
            <dbReference type="PROSITE" id="PS50963"/>
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    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056594.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="2554" mass="277430" checksum="FDA9B94D169C5A02" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NVY5</accession>
    <name>A0A8I5NVY5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inactive ribonuclease-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RNASE9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Does not exhibit any ribonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NVY5"/>
    <dbReference type="Ensembl" id="ENSPANT00000074575.1">
        <property type="protein sequence ID" value="ENSPANP00000060292.1"/>
        <property type="gene ID" value="ENSPANG00000039662.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013952"/>
    <dbReference type="OMA" id="PCKNGVK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00163">
        <property type="entry name" value="RNase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.130.10:FF:000003">
        <property type="entry name" value="Inactive ribonuclease-like protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF14">
        <property type="entry name" value="INACTIVE RIBONUCLEASE-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199593" description="Inactive ribonuclease-like protein 9" evidence="9">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="10">
        <location>
            <begin position="62"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="209" mass="24985" checksum="67159266E7AB92A6" modified="2022-05-25" version="1">MSTGKMMRTLITTHPLLLLLLLQQLLQPVQFQEVDTDFDSPDDDMEEFEEYLEEFHRTGPTRPPTKEKVERRVIIEPGMPLYDRNYCNEEIMRKNVYHKQRCVTEHYFLLMQYDELQKICYNRFVPCKNGVRKCNRSKGLVEGVYCNLTEAFEIPWCKYESFYRRGYVLITCTWQNEIHKLIPHTINDLVEPPKHRSFLNEDGVFVIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P130</accession>
    <name>A0A8I5P130_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23 24">Adenylate cyclase type 2</fullName>
            <ecNumber evidence="5 24">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ADCY2</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 24">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="26">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="26">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with RAF1. Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24 27">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5 24"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5P130"/>
    <dbReference type="Ensembl" id="ENSPANT00000068234.1">
        <property type="protein sequence ID" value="ENSPANP00000058014.1"/>
        <property type="gene ID" value="ENSPANG00000014159.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156424"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000003">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000010">
        <property type="entry name" value="Adenylate cyclase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF6">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 24 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 24" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20 24 27" id="KW-0456">Lyase</keyword>
    <keyword evidence="14 24 26" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 26" id="KW-0464">Manganese</keyword>
    <keyword evidence="17 24 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 24 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="29">
        <location>
            <begin position="290"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="29">
        <location>
            <begin position="834"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="295"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="966"/>
            <end position="968"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="973"/>
            <end position="977"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1013"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00070505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRNR" id="PIRNR039050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116886" checksum="FB29AB48FF6FBC87" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2C0</accession>
    <name>A0A8I5P2C0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5P2C0"/>
    <dbReference type="Ensembl" id="ENSPANT00000069609.1">
        <property type="protein sequence ID" value="ENSPANP00000059083.1"/>
        <property type="gene ID" value="ENSPANG00000043111.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="OMA" id="HESKACG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element trimerization" evidence="16">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="15">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="17">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="386" mass="44919" checksum="62B8A26F358EA98D" modified="2022-05-25" version="1">MGKKQGRKAGNSKNKSASPPAKERSSSPAMDQSWTENDFDEMREEGFSPSNFSELKEELRTQRKETKNLEKKVEELMARVINAEKVINEMKEMKTMTREIRDKCTSFSNRLDQLEERVSAIEDQMNEMKREEKPKEKRRKRNEQSLQEVWDYVKRPNLRLIGVPESEGENGTTLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSSRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTADLSAETLQARREWGPIFNILKEKTFFLPSFLPSFLLSFLPSFLPSFLPSFLPSFLPSFLLSFLPSSLSFFFSFSFFLSEILKKCVTDTLSLYMFMGYSVLFQCTHTLYNDQIGIVTTSVTLDIYHFFVVTTFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2L9</accession>
    <name>A0A8I5P2L9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein prune homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">BNIP2 motif-containing molecule at the C-terminal region 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRUNE2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Subunit of the 40S ribosomal complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Subunit of the 40S ribosomal complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R0N1"/>
    <dbReference type="Ensembl" id="ENSPANT00000082126.1">
        <property type="protein sequence ID" value="ENSPANP00000053437.1"/>
        <property type="gene ID" value="ENSPANG00000032106.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018318"/>
    <dbReference type="OMA" id="CIETEFD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000011">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="7">
        <location>
            <begin position="78"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="193" mass="21709" checksum="EF7E2299072AD2DB" modified="2022-05-25" version="1">MRPLSLPPRSRAEAEAWVRSRFRFTRNPPPWPRKGEPRGRVWSWGRGSAEAWAWSWRSRTGSNGLPIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R5U7</accession>
    <name>A0A8I5R5U7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R5U7"/>
    <dbReference type="Ensembl" id="ENSPANT00000060897.1">
        <property type="protein sequence ID" value="ENSPANP00000050369.1"/>
        <property type="gene ID" value="ENSPANG00000043340.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166009"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="111" mass="12588" checksum="5D46586BC7B71DF0" modified="2022-05-25" version="1">KEYHLDRDSKIATCTFADHAVPGGTFRRRHSGPVSEECSLPRSRQKLAQLEEAKQASIQQIQNAIDMEKSQQALTQKRHYLFDVQREKETVAKCIADLKLLAKKAQAPPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A9CB53</accession>
    <name>A9CB53_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transmembrane protein 187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">TMEM187</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="DP000488">
        <property type="protein sequence ID" value="ABX10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162267.1">
        <property type="nucleotide sequence ID" value="NM_001168796.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009196761.1">
        <property type="nucleotide sequence ID" value="XM_009198497.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031516255.1">
        <property type="nucleotide sequence ID" value="XM_031660395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9CB53"/>
    <dbReference type="Ensembl" id="ENSPANT00000068222.1">
        <property type="protein sequence ID" value="ENSPANP00000048996.1"/>
        <property type="gene ID" value="ENSPANG00000050796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100137258"/>
    <dbReference type="KEGG" id="panu:100137258"/>
    <dbReference type="CTD" id="8269"/>
    <dbReference type="eggNOG" id="ENOG502QUS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011272"/>
    <dbReference type="HOGENOM" id="CLU_093204_0_0_1"/>
    <dbReference type="OMA" id="FLAMPCN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028066">
        <property type="entry name" value="TMEM187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15066">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15066:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15100">
        <property type="entry name" value="TMEM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABX10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="261" mass="29128" checksum="B5915F6F3334D958" modified="2008-01-15" version="1">MNPEWGQAFMHVAVAGGLCAVAVFTGIFDSVSVQVGYEDYAEAPVAGLPAFLAMPFNSLVNVAYTLLGLFWLHRGGAVGPGPRYLKDVFAAMALLYGPVQWLRLWTQWRRTAVLDQWLTLPIFAWPVAWCLYLDHGWRPWLFLSLECISLASYGLALLHPRGFEVALGAHVVAAVGQALRTHRHYGSTTSATYLALGVLSCLGFVVLKLCDHQLARWHLFQRLTGHFWSKVCDVLQFHFAFLFLTHFNTHPRCCPSGGKTH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A9RA82</accession>
    <name>KATL1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Katanin p60 ATPase-containing subunit A-like 1</fullName>
            <shortName evidence="4">Katanin p60 subunit A-like 1</shortName>
            <ecNumber evidence="4">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">p60 katanin-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KATNAL1</name>
    </gene>
    <organism>
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2007-12" db="EMBL/GenBank/DDBJ databases">
            <title>NISC comparative sequencing initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with KATNB1 and KATNBL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <text evidence="2 3">Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="DP000511">
        <property type="protein sequence ID" value="ABX89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162539.1">
        <property type="nucleotide sequence ID" value="NM_001169068.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021785039.1">
        <property type="nucleotide sequence ID" value="XM_021929347.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021785040.1">
        <property type="nucleotide sequence ID" value="XM_021929348.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021785042.1">
        <property type="nucleotide sequence ID" value="XM_021929350.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9RA82"/>
    <dbReference type="SMR" id="A9RA82"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009005"/>
    <dbReference type="Ensembl" id="ENSPANT00000078021.1">
        <property type="protein sequence ID" value="ENSPANP00000051502.1"/>
        <property type="gene ID" value="ENSPANG00000023364.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137574"/>
    <dbReference type="KEGG" id="panu:100137574"/>
    <dbReference type="CTD" id="84056"/>
    <dbReference type="eggNOG" id="KOG0738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156630"/>
    <dbReference type="OMA" id="TAKMMPV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:katanin complex"/>
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        <property type="term" value="C:microtubule"/>
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        <property type="term" value="C:mitotic spindle"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="term" value="P:microtubule severing"/>
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        <property type="term" value="P:spermatogenesis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19522">
        <property type="entry name" value="RecA-like_KTNA1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.8.60:FF:000025">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
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        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Katanin_p60_AL1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028594">
        <property type="entry name" value="Katnal1_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048612">
        <property type="entry name" value="KTNA1_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF65">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
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        <property type="entry name" value="KATNA1_MIT"/>
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        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000367124" description="Katanin p60 ATPase-containing subunit A-like 1">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
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    <feature type="binding site" evidence="4">
        <location>
            <begin position="248"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylmethionine" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q5XIK7"/>
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    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8K0T4"/>
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    </evidence>
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        <source>
            <dbReference type="UniProtKB" id="Q9BW62"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="490" mass="55312" checksum="034DAB7601DE345A" modified="2008-02-05" version="1">MNLAEICDNAKKGREYALLGNYDSSMVYYQGVIQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSIVSTLESFKIDRPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDCRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLGPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K9MUH0</accession>
    <name>K9MUH0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">NADH-ubiquinone oxidoreductase chain 6</fullName>
            <ecNumber evidence="3 18">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ND6</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="19 21"/>
    <reference evidence="19 21 22" key="1">
        <citation type="journal article" date="2013" name="Am. J. Phys. Anthropol." volume="150" first="133" last="140">
            <title>Baboon phylogeny as inferred from complete mitochondrial genomes.</title>
            <authorList>
                <person name="Zinner D."/>
                <person name="Wertheimer J."/>
                <person name="Liedigk R."/>
                <person name="Groeneveld L.F."/>
                <person name="Roos C."/>
            </authorList>
            <dbReference type="PubMed" id="23180628"/>
            <dbReference type="DOI" id="10.1002/ajpa.22185"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">East</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E69504" last="E69504">
            <title>A mitogenomic phylogeny of living primates.</title>
            <authorList>
                <person name="Finstermeier K."/>
                <person name="Zinner D."/>
                <person name="Brameier M."/>
                <person name="Meyer M."/>
                <person name="Kreuz E."/>
                <person name="Hofreiter M."/>
                <person name="Roos C."/>
            </authorList>
            <dbReference type="PubMed" id="23874967"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15 18">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 18"/>
    <dbReference type="EMBL" id="JX946196">
        <property type="protein sequence ID" value="AFX82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KC757406">
        <property type="protein sequence ID" value="AGM47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007316894.1">
        <property type="nucleotide sequence ID" value="NC_020006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K9MUH0"/>
    <dbReference type="SMR" id="K9MUH0"/>
    <dbReference type="Ensembl" id="ENSPANT00000065410.1">
        <property type="protein sequence ID" value="ENSPANP00000053512.1"/>
        <property type="gene ID" value="ENSPANG00000039767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="14444640"/>
    <dbReference type="KEGG" id="panu:14444640"/>
    <dbReference type="CTD" id="4541"/>
    <dbReference type="eggNOG" id="ENOG502S2Q2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003988"/>
    <dbReference type="HOGENOM" id="CLU_129718_0_0_1"/>
    <dbReference type="OMA" id="WVIYDTG"/>
    <dbReference type="OrthoDB" id="9837654at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050269">
        <property type="entry name" value="ComplexI_Subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11435">
        <property type="entry name" value="NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11435:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 18 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 18" id="KW-0520">NAD</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFX82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AGM47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="174" mass="18775" checksum="E08E58DA73D7E878" modified="2013-03-06" version="1">MTYVLFTLSVMLVMGFVGFSSKPSPIYGGLALVVSGVVGCMIILNYGGAYLGLVMFLIYLGGMMVVFGYTAAMAIEEYPETWGSGFEVLACFLVGLMMEVGLVLWVLDFDEVVVMVGFNDMGNWVVFEGEGSGLVRSDSIGAGALYDYGRWLVVVAGWTLFVGVYVVIEITRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKP2</accession>
    <name>A0A096MKP2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FERM domain containing 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FRMD7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MKP2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000060"/>
    <dbReference type="Ensembl" id="ENSPANT00000027461.3">
        <property type="protein sequence ID" value="ENSPANP00000000060.2"/>
        <property type="gene ID" value="ENSPANG00000010662.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158972"/>
    <dbReference type="HOGENOM" id="CLU_030239_0_0_1"/>
    <dbReference type="OMA" id="PYIPCTS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010662">
        <property type="expression patterns" value="Expressed in olfactory bulb and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17188">
        <property type="entry name" value="FERM_F1_FRMD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000060.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="714" mass="81436" checksum="2D3FBC49A3627731" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MLW2</accession>
    <name>A0A096MLW2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLDN24</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017814724.1">
        <property type="nucleotide sequence ID" value="XM_017959235.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MLW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000560"/>
    <dbReference type="Ensembl" id="ENSPANT00000003366.3">
        <property type="protein sequence ID" value="ENSPANP00000000560.1"/>
        <property type="gene ID" value="ENSPANG00000004497.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016784"/>
    <dbReference type="KEGG" id="panu:101016784"/>
    <dbReference type="CTD" id="100132463"/>
    <dbReference type="eggNOG" id="ENOG502RSH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162234"/>
    <dbReference type="HOGENOM" id="CLU_076370_1_2_1"/>
    <dbReference type="OMA" id="MQTQCPY"/>
    <dbReference type="OrthoDB" id="8612291at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004497">
        <property type="expression patterns" value="Expressed in adult mammalian kidney"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="220" mass="24394" checksum="ACA3117BBFE3003A" modified="2014-11-26" version="1">MALIFRIVMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVTQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGEGQRDLKRRLLILGGVLSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLNCAACSSHAPLASGHYAVAQIQTQCPYLEDGTADPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMB6</accession>
    <name>A0A096MMB6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphodiesterase</fullName>
            <ecNumber evidence="16">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PDE3B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16958"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:14654"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="16">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003910234.1">
        <property type="nucleotide sequence ID" value="XM_003910185.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MMB6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000739"/>
    <dbReference type="Ensembl" id="ENSPANT00000028853.3">
        <property type="protein sequence ID" value="ENSPANP00000000739.1"/>
        <property type="gene ID" value="ENSPANG00000014364.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019574"/>
    <dbReference type="KEGG" id="panu:101019574"/>
    <dbReference type="CTD" id="5140"/>
    <dbReference type="eggNOG" id="ENOG502QSV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159336"/>
    <dbReference type="HOGENOM" id="CLU_008844_1_0_1"/>
    <dbReference type="OMA" id="GRRQIFC"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014364">
        <property type="expression patterns" value="Expressed in perirenal fat and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MMB6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106072">
        <property type="term" value="P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050995">
        <property type="term" value="P:negative regulation of lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000008">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
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    </dbReference>
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        <property type="entry name" value="PDEase_I"/>
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        <property type="entry name" value="HDc"/>
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    </dbReference>
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        <property type="entry name" value="HD-domain/PDEase-like"/>
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        <property type="entry name" value="PDEASE_I_1"/>
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        <property type="entry name" value="PDEASE_I_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0114">cAMP</keyword>
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    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="19">
        <location>
            <begin position="651"/>
            <end position="1079"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="418"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1017"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1092"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1017"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033675"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033684"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033709"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51845"/>
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            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMP9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <source>
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    <sequence length="74" mass="8303" checksum="4377F0B64C78874D" modified="2014-11-26" version="1">MKFQECHSEVMRHGQKIYPSHHRIEMAVEIASLKCQHSSINQSPTRKNSNSTTGRLLWDLLLGIGNSGSNVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MN46</accession>
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        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 92</fullName>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
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                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
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                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
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                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
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                <person name="Pham C.P."/>
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                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Newsham I.N."/>
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                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003907350.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009180249.1">
        <property type="nucleotide sequence ID" value="XM_009181985.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017801796.1">
        <property type="nucleotide sequence ID" value="XM_017946307.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MN46"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001038"/>
    <dbReference type="Ensembl" id="ENSPANT00000015344.3">
        <property type="protein sequence ID" value="ENSPANP00000001038.1"/>
        <property type="gene ID" value="ENSPANG00000017666.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015985"/>
    <dbReference type="KEGG" id="panu:101015985"/>
    <dbReference type="CTD" id="80212"/>
    <dbReference type="eggNOG" id="ENOG502QQWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00430000031027"/>
    <dbReference type="HOGENOM" id="CLU_076253_0_0_1"/>
    <dbReference type="OMA" id="AHRIHHG"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017666">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="331" mass="37049" checksum="A9191222A936C10E" modified="2014-11-26" version="1">MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSRSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASPSGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAMPDPTPFLLARESAEVHLIKERPLVIPPIASDRSSEQHSPAREKPHKAHVGVAHRIHHATPPQAQPEVKTLAVDQVNGSKVVRKHSGTDRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPG5</accession>
    <name>A0A096MPG5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Mitochondrial adenyl nucleotide antiporter SLC25A24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Solute carrier family 25 member 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">SLC25A24</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73679"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:60880"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73691"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60880"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73671"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ADP(out) + phosphate(in) + H(+)(out) = ADP(in) + phosphate(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:65844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>AMP(out) + phosphate(in) = AMP(in) + phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:70259"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Mg(2+)(in) + ADP(out) + ATP(in) + H(+)(out) = Mg(2+)(out) + ADP(in) + ATP(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73659"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>Mg(2+)(out) + phosphate(in) + ATP(out) = Mg(2+)(in) + phosphate(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:65840"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dADP(in) + ADP(out) = dADP(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72855"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dADP(out) + phosphate(in) + H(+)(out) = dADP(in) + phosphate(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dAMP(in) + ADP(out) + H(+)(out) = dAMP(out) + ADP(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73687"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>phosphate(in) + ATP(out) + 2 H(+)(out) = phosphate(out) + ATP(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72035"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 30">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892345.1">
        <property type="nucleotide sequence ID" value="XM_003892296.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MPG5"/>
    <dbReference type="SMR" id="A0A096MPG5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001618"/>
    <dbReference type="Ensembl" id="ENSPANT00000019961.3">
        <property type="protein sequence ID" value="ENSPANP00000001618.1"/>
        <property type="gene ID" value="ENSPANG00000012520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023671"/>
    <dbReference type="KEGG" id="panu:101023671"/>
    <dbReference type="CTD" id="29957"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158786"/>
    <dbReference type="HOGENOM" id="CLU_015166_2_0_1"/>
    <dbReference type="OMA" id="SGQWWKQ"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012520">
        <property type="expression patterns" value="Expressed in caecum and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MPG5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140988">
        <property type="term" value="F:ADP:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140987">
        <property type="term" value="F:ATP:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000028">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000003">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000168">
        <property type="entry name" value="Solute carrier family 25 member 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 29 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 30" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="31">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="31">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="31">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="29">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="29">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="29">
        <location>
            <begin position="383"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00053214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00070249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00076493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="477" mass="53251" checksum="492B6B1A9D4A51B9" modified="2014-11-26" version="1">MLRWLRGFVLPTAACQEAEPPTRYETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDADGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQW3</accession>
    <name>A0A096MQW3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PIGW</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A096MQW3"/>
    <dbReference type="Ensembl" id="ENSPANT00000028804.3">
        <property type="protein sequence ID" value="ENSPANP00000002148.3"/>
        <property type="gene ID" value="ENSPANG00000008702.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013520"/>
    <dbReference type="HOGENOM" id="CLU_020802_2_1_1"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008702">
        <property type="expression patterns" value="Expressed in perirenal fat and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQW3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002148.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="527" mass="59838" checksum="DA48D6B9A598E500" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRT2</accession>
    <name>A0A096MRT2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal biosis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RBIS</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MRT2"/>
    <dbReference type="Ensembl" id="ENSPANT00000008726.3">
        <property type="protein sequence ID" value="ENSPANP00000002489.3"/>
        <property type="gene ID" value="ENSPANG00000021683.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015564"/>
    <dbReference type="HOGENOM" id="CLU_152931_0_0_1"/>
    <dbReference type="OMA" id="FQVANRH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021683">
        <property type="expression patterns" value="Expressed in optic disc and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRT2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031389">
        <property type="entry name" value="RBIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35544">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35544:SF4">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15679">
        <property type="entry name" value="DUF4665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002489.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="100" mass="11389" checksum="C096819F6BD17AC1" modified="2022-05-25" version="3">MGKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNDEKVNRVNKAFVNVQKELAHFSKGPSIEPLQKELIPQQRRESKPVNVDEATKLMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRV9</accession>
    <name>A0A096MRV9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="18">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PYCR2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:14107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:14111"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodecamer; composed of 5 homodimers. Interacts with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="18"/>
    <dbReference type="RefSeq" id="XP_021782364.2">
        <property type="nucleotide sequence ID" value="XM_021926672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRV9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002518"/>
    <dbReference type="Ensembl" id="ENSPANT00000008044.3">
        <property type="protein sequence ID" value="ENSPANP00000002518.3"/>
        <property type="gene ID" value="ENSPANG00000013395.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012066"/>
    <dbReference type="CTD" id="29920"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183044"/>
    <dbReference type="HOGENOM" id="CLU_042344_3_0_1"/>
    <dbReference type="OMA" id="YYFIESL"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013395">
        <property type="expression patterns" value="Expressed in pineal body and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRV9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000064">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000003">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF61">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17 18" id="KW-0521">NADP</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 18" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="19">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="20">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002518.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="320" mass="33647" checksum="0CC8AFC637996BD7" modified="2022-05-25" version="3">MSVGIIGAGQLAYALARGFTAAGIVSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYAMGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCVRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSLALGGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MT52</accession>
    <name>A0A096MT52_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 family 4 subfamily B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">CYP4B1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MT52"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002976"/>
    <dbReference type="Ensembl" id="ENSPANT00000005114.3">
        <property type="protein sequence ID" value="ENSPANP00000002976.3"/>
        <property type="gene ID" value="ENSPANG00000005048.3"/>
    </dbReference>
    <dbReference type="VGNC" id="VGNC:81859">
        <property type="gene designation" value="CYP4B1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161441"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_1"/>
    <dbReference type="OMA" id="IQPAFRL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005048">
        <property type="expression patterns" value="Expressed in lung and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF149">
        <property type="entry name" value="CYTOCHROME P450 4B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002976.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="VGNC" id="VGNC:81859"/>
        </source>
    </evidence>
    <sequence length="512" mass="58865" checksum="CD096DBC39598511" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MU27</accession>
    <name>A0A096MU27_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">APOO</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917556.1">
        <property type="nucleotide sequence ID" value="XM_003917507.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003917557.1">
        <property type="nucleotide sequence ID" value="XM_003917508.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195606.1">
        <property type="nucleotide sequence ID" value="XM_009197342.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MU27"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003321"/>
    <dbReference type="Ensembl" id="ENSPANT00000026250.3">
        <property type="protein sequence ID" value="ENSPANP00000003321.1"/>
        <property type="gene ID" value="ENSPANG00000009164.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101004207"/>
    <dbReference type="KEGG" id="panu:101004207"/>
    <dbReference type="CTD" id="79135"/>
    <dbReference type="eggNOG" id="KOG4798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063666"/>
    <dbReference type="HOGENOM" id="CLU_048383_1_0_1"/>
    <dbReference type="OrthoDB" id="9421762at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009164">
        <property type="expression patterns" value="Expressed in heart and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MU27">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="198" mass="22312" checksum="536BDF2C64EC12CA" modified="2014-11-26" version="1">MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQNLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVD8</accession>
    <name>A0A096MVD8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Amino acid transporter heavy chain SLC3A2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">4F2 cell-surface antigen heavy chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 3 member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">SLC3A2</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the SLC3A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MVD8"/>
    <dbReference type="Ensembl" id="ENSPANT00000025236.3">
        <property type="protein sequence ID" value="ENSPANP00000003813.3"/>
        <property type="gene ID" value="ENSPANG00000012315.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156646"/>
    <dbReference type="HOGENOM" id="CLU_006462_9_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012315">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MVD8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015827">
        <property type="term" value="P:tryptophan transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11345">
        <property type="entry name" value="AmyAc_SLC3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000012">
        <property type="entry name" value="4F2 cell-surface antigen heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000061">
        <property type="entry name" value="4F2 cell-surface antigen heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20" id="KW-0458">Lysosome</keyword>
    <keyword evidence="17 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="27">
        <location>
            <begin position="168"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00075109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00080116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003813.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="568" mass="61890" checksum="DFAFE942B21B6011" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXK3</accession>
    <name>A0A096MXK3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi associated kinase 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GASK1A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GASK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017810182.3">
        <property type="nucleotide sequence ID" value="XM_017954693.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MXK3"/>
    <dbReference type="Ensembl" id="ENSPANT00000016788.3">
        <property type="protein sequence ID" value="ENSPANP00000004621.3"/>
        <property type="gene ID" value="ENSPANG00000011902.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003336"/>
    <dbReference type="KEGG" id="panu:101003336"/>
    <dbReference type="CTD" id="729085"/>
    <dbReference type="eggNOG" id="ENOG502RYY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029769"/>
    <dbReference type="HOGENOM" id="CLU_033542_1_0_1"/>
    <dbReference type="OMA" id="WFTEHDV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011902">
        <property type="expression patterns" value="Expressed in pineal body and 40 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MXK3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029207">
        <property type="entry name" value="FAM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15905:SF5">
        <property type="entry name" value="GOLGI-ASSOCIATED KINASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15905">
        <property type="entry name" value="GOLGI-ASSOCIATED KINASE 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15051">
        <property type="entry name" value="FAM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035157504" evidence="7">
        <location>
            <begin position="30"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004621.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="575" mass="63769" checksum="E622143D30A26338" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MY80</accession>
    <name>A0A096MY80_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Acetylcholine receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CHRNA1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">One of the alpha chains that assemble within the acetylcholine receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MY80"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004879"/>
    <dbReference type="Ensembl" id="ENSPANT00000008601.3">
        <property type="protein sequence ID" value="ENSPANP00000004879.1"/>
        <property type="gene ID" value="ENSPANG00000007790.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156851"/>
    <dbReference type="HOGENOM" id="CLU_018074_1_0_1"/>
    <dbReference type="OMA" id="GHITWNP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007790">
        <property type="expression patterns" value="Expressed in visual cortex and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MY80">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042166">
        <property type="term" value="F:acetylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015464">
        <property type="term" value="F:acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048630">
        <property type="term" value="P:skeletal muscle tissue growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19014">
        <property type="entry name" value="LGIC_ECD_nAChR_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000013">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000016">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.70.170.10:FF:000019">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="23">
        <location>
            <begin position="69"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="24">
        <location>
            <begin position="283"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="502" mass="57271" checksum="430A8EBC3F563ABD" modified="2014-11-26" version="1">MEGGRDPEQMLMRWDTFSRSQAPSQSASEKYRPPLCPGPHKLRWPMEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHHQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDFVLYNNADGDFAIVKFTKVLLDHTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVVINPESDQPDLSNFMESGEWVIKESRGWKHWVFYSCCPNTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPDWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYT2</accession>
    <name>A0A096MYT2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">A disintegrin and metalloproteinase with thrombospondin motifs 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ADMP-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Aggrecanase-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ADAMTS5</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021791242.2">
        <property type="nucleotide sequence ID" value="XM_021935550.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031521539.1">
        <property type="nucleotide sequence ID" value="XM_031665679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYT2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005102"/>
    <dbReference type="Ensembl" id="ENSPANT00000001478.3">
        <property type="protein sequence ID" value="ENSPANP00000005102.2"/>
        <property type="gene ID" value="ENSPANG00000015990.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002196"/>
    <dbReference type="KEGG" id="panu:101002196"/>
    <dbReference type="CTD" id="11096"/>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159090"/>
    <dbReference type="HOGENOM" id="CLU_000660_3_0_1"/>
    <dbReference type="OMA" id="TPCPPNG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015990">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003180">
        <property type="term" value="P:aortic valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003203">
        <property type="term" value="P:endocardial cushion morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003184">
        <property type="term" value="P:pulmonary valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013276">
        <property type="entry name" value="Pept_M12B_ADAM-TS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF37">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01860">
        <property type="entry name" value="ADAMTS5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12 20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="8 17 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228239" description="A disintegrin and metalloproteinase with thrombospondin motifs 5" evidence="23">
        <location>
            <begin position="21"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="24">
        <location>
            <begin position="267"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 21">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="19">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 21">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 21">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 21">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="20">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="20">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="342"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="371"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="388"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR613276-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR613276-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005102.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="930" mass="101780" checksum="ABD531EA0864FB9F" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZA4</accession>
    <name>A0A096MZA4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Keratin, type I cytoskeletal 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytokeratin-19</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Keratin-19</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MZA4"/>
    <dbReference type="Ensembl" id="ENSPANT00000006623.3">
        <property type="protein sequence ID" value="ENSPANP00000005299.3"/>
        <property type="gene ID" value="ENSPANG00000033183.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QV0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155258"/>
    <dbReference type="HOGENOM" id="CLU_012560_8_1_1"/>
    <dbReference type="OMA" id="SAMLCIS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033183">
        <property type="expression patterns" value="Expressed in ascending colon and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF14">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="11">
        <location>
            <begin position="80"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="289"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005299.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="368" mass="40719" checksum="DCC5714080CAA2E6" modified="2022-05-25" version="3">MTSYSYLQWSAMSSVGGLGGGSVRFGPGVAFRAPSMHGGSGGRGVSVSSARFVSSSSSGGYGGGYGGVLAASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDNILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSLEADINGLRRVLEELTLARTDLEMQIEGLKEELAYLKKNHEEEISVLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWVTSRTEESNRELSGHTEQLQISRSEVTDLRRTLQGLEIELQSQLSMLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZD2</accession>
    <name>A0A096MZD2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 8 open reading frame 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C8orf74</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MZD2"/>
    <dbReference type="Ensembl" id="ENSPANT00000010555.3">
        <property type="protein sequence ID" value="ENSPANP00000005328.3"/>
        <property type="gene ID" value="ENSPANG00000005669.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RYV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154323"/>
    <dbReference type="HOGENOM" id="CLU_081156_0_0_1"/>
    <dbReference type="OMA" id="YQFVLCR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005669">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF2">
        <property type="entry name" value="SIMILAR TO 4930578I06RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005328.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="295" mass="34049" checksum="510D66CF9983BBBF" modified="2022-05-25" version="3">MALLTPRGVKEVFQSQRLPQGRERLRRLLNWEEFDEQRDSRRSILLDTLYDSIIFAVGKGFPWVQVAQVVKFTEELLRETKGCSITEAVTILGNKLRDYQDHFNTTHLLALCDYFHHTFIRHYKLYQYVLGQDQQVSLTVAHLEVCMPPQPLPLAEGMDRDLWTHRQQVVALTEAEAQKRADVLLLKETLLLELESSLQKVFTAAAPAQPGRVLERQELESLVRQVIHIQMELLQELLQCKIQNTFAILDLKLQKKTLNLNAPTPNPPPITSHAGQEEALKPHRVNKEKKVKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZM4</accession>
    <name>A0A096MZM4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Semaphorin 3D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SEMA3D</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009201793.1">
        <property type="nucleotide sequence ID" value="XM_009203529.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017812487.1">
        <property type="nucleotide sequence ID" value="XM_017956998.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZM4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005428"/>
    <dbReference type="Ensembl" id="ENSPANT00000009655.3">
        <property type="protein sequence ID" value="ENSPANP00000005428.2"/>
        <property type="gene ID" value="ENSPANG00000010212.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011388"/>
    <dbReference type="KEGG" id="panu:101011388"/>
    <dbReference type="CTD" id="223117"/>
    <dbReference type="eggNOG" id="KOG3611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156681"/>
    <dbReference type="HOGENOM" id="CLU_009051_5_0_1"/>
    <dbReference type="OMA" id="KIYWPAT"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010212">
        <property type="expression patterns" value="Expressed in spleen and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZM4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05871">
        <property type="entry name" value="Ig_Sema3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11252">
        <property type="entry name" value="Sema_3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000015">
        <property type="entry name" value="Semaphorin 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000001">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042582">
        <property type="entry name" value="Sema3D_Sema"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF36">
        <property type="entry name" value="SEMAPHORIN-3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="44"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="738"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005428.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="777" mass="89555" checksum="7823016480768BB8" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1K6</accession>
    <name>A0A096N1K6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA topoisomerase 2-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DNA topoisomerase II-beta-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">DNA topoisomerase II-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TOPBP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the TOPBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895149.2">
        <property type="nucleotide sequence ID" value="XM_003895100.4"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000006180"/>
    <dbReference type="Ensembl" id="ENSPANT00000023488.3">
        <property type="protein sequence ID" value="ENSPANP00000006180.2"/>
        <property type="gene ID" value="ENSPANG00000008323.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000224"/>
    <dbReference type="KEGG" id="panu:101000224"/>
    <dbReference type="CTD" id="11073"/>
    <dbReference type="eggNOG" id="KOG1929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157001"/>
    <dbReference type="HOGENOM" id="CLU_004165_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008323">
        <property type="expression patterns" value="Expressed in axillary lymph node and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17737">
        <property type="entry name" value="BRCT_TopBP1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17718">
        <property type="entry name" value="BRCT_TopBP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17749">
        <property type="entry name" value="BRCT_TopBP1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18434">
        <property type="entry name" value="BRCT_TopBP1_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17727">
        <property type="entry name" value="BRCT_TopBP1_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17728">
        <property type="entry name" value="BRCT_TopBP1_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000018">
        <property type="entry name" value="DNA topoisomerase 2-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000028">
        <property type="entry name" value="DNA topoisomerase 2-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000010">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000020">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000021">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000022">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000023">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000029">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000033">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
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        <property type="entry name" value="Secretoglobin_sf"/>
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        <property type="entry name" value="TopB1_SLF1_BRCT"/>
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        <property type="entry name" value="TopBP1_BRCT_1"/>
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        <property type="entry name" value="TopBP1_BRCT_8"/>
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        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
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        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
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        <property type="entry name" value="BRCT_TopB1_SLF1"/>
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        <property type="entry name" value="TopBP1_BRCT0"/>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
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    <dbReference type="SUPFAM" id="SSF48201">
        <property type="entry name" value="Uteroglobin-like"/>
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        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="195"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="354"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="553"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="646"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="905"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="1264"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="492"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1123"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1506"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006180.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1527" mass="171352" checksum="891FC05F467C89AD" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N1S0</accession>
    <name>A0A096N1S0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Aortic preferentially expressed protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SPEG</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="NP_001162568.3">
        <property type="nucleotide sequence ID" value="NM_001169097.3"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000006252"/>
    <dbReference type="Ensembl" id="ENSPANT00000010231.3">
        <property type="protein sequence ID" value="ENSPANP00000006252.3"/>
        <property type="gene ID" value="ENSPANG00000008602.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137606"/>
    <dbReference type="KEGG" id="panu:100137606"/>
    <dbReference type="CTD" id="10290"/>
    <dbReference type="eggNOG" id="KOG0032">
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    <dbReference type="eggNOG" id="KOG0613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161126"/>
    <dbReference type="HOGENOM" id="CLU_000381_2_0_1"/>
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        <property type="component" value="Chromosome 10"/>
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    <dbReference type="Bgee" id="ENSPANG00000008602">
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="FN3"/>
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        <property type="entry name" value="IgI_APEG-1_like"/>
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        <property type="entry name" value="STKc_SPEG_rpt1"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N277</accession>
    <name>A0A096N277_PAPAN</name>
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        <recommendedName>
            <fullName evidence="23">Acyl-coenzyme A thioesterase MBLAC2</fullName>
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        <alternativeName>
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        <alternativeName>
            <fullName evidence="24">Metallo-beta-lactamase domain-containing protein 2</fullName>
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        <alternativeName>
            <fullName evidence="26">Palmitoyl-coenzyme A thioesterase MBLAC2</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:30140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="18"/>
    <dbReference type="EC" id="3.5.2.6" evidence="6"/>
    <dbReference type="RefSeq" id="XP_003899964.1">
        <property type="nucleotide sequence ID" value="XM_003899915.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N277"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006420"/>
    <dbReference type="Ensembl" id="ENSPANT00000023955.3">
        <property type="protein sequence ID" value="ENSPANP00000006420.1"/>
        <property type="gene ID" value="ENSPANG00000001530.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022450"/>
    <dbReference type="KEGG" id="panu:101022450"/>
    <dbReference type="CTD" id="153364"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017819"/>
    <dbReference type="HOGENOM" id="CLU_030571_0_2_1"/>
    <dbReference type="OMA" id="VASHTHF"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001530">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07712">
        <property type="entry name" value="MBLAC2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000026">
        <property type="entry name" value="metallo-beta-lactamase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE MBLAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0564">Palmitate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="27">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="279" mass="31269" checksum="E362B63E436B3C59" modified="2014-11-26" version="1">MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVIDTGLGLRSLPEYLYSSGLLQDRGAKEDAARRPLLAVATHVHFDHSGGLYQFDRVAVHHAEAEALARGDNFETVTWLSDSEVVRAPSPGWRARQFRVQAVQPTLILQDGDVINLGDRQLTVMHMPGHSRGSICLHDKDRKILFSGDVVYDGSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNSRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N3S9</accession>
    <name>A0A096N3S9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GA binding protein transcription factor subunit beta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GABPB2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021779317.1">
        <property type="nucleotide sequence ID" value="XM_021923625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N3S9"/>
    <dbReference type="Ensembl" id="ENSPANT00000000504.4">
        <property type="protein sequence ID" value="ENSPANP00000007020.2"/>
        <property type="gene ID" value="ENSPANG00000015567.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100998660"/>
    <dbReference type="KEGG" id="panu:100998660"/>
    <dbReference type="CTD" id="126626"/>
    <dbReference type="GeneTree" id="ENSGT00940000156794"/>
    <dbReference type="OMA" id="NMNQVNL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015567">
        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N3S9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000025">
        <property type="entry name" value="GA-binding protein subunit beta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF86">
        <property type="entry name" value="GA-BINDING PROTEIN SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007020.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="410" mass="44937" checksum="CEDA0D388BD4D085" modified="2018-02-28" version="2">MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVTMAAPFIFTSGEVVNLTSLVSSANTKTTSANSEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTMQDGQQVLTVPAGQVAEETVIKEEEEEKLPLTKKPRIGEMTNSVEESKEGNERELLQQQLLEANRRAQEYRHQLLKKEQEAEQYRRKLEAIARQQPSGVDFTMVEEVAEVNAVVVTEGELEERETQVTGSAGTTEPHTRVSMETVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N447</accession>
    <name>A0A096N447_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein heavy chain domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 35</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Dynein heavy chain domain 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DNHD1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000007146"/>
    <dbReference type="Ensembl" id="ENSPANT00000003439.3">
        <property type="protein sequence ID" value="ENSPANP00000007146.3"/>
        <property type="gene ID" value="ENSPANG00000009251.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155523"/>
    <dbReference type="HOGENOM" id="CLU_000038_0_3_1"/>
    <dbReference type="OMA" id="SRNIVMH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009251">
        <property type="expression patterns" value="Expressed in liver and 37 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120316">
        <property type="term" value="P:sperm flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000008">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000010">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000011">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000008">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000007">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001411">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001476">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001491">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001540">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001566">
        <property type="entry name" value="Dynein heavy chain domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001336">
        <property type="entry name" value="Dynein heavy chain domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000018">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF359">
        <property type="entry name" value="DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="14">
        <location>
            <begin position="1017"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="1649"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="18">
        <location>
            <begin position="2268"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="20">
        <location>
            <begin position="2548"/>
            <end position="2668"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="17">
        <location>
            <begin position="2867"/>
            <end position="3126"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="16">
        <location>
            <begin position="3196"/>
            <end position="3468"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="13">
        <location>
            <begin position="4103"/>
            <end position="4229"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="19">
        <location>
            <begin position="4442"/>
            <end position="4748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2690"/>
            <end position="2761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3579"/>
            <end position="3657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="4670"/>
            <end position="4699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3132"/>
            <end position="3225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="4437"/>
            <end position="4464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2698"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2741"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="3604"/>
            <end position="3613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3614"/>
            <end position="3633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007146.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="4754" mass="533273" checksum="70956FD02C51776C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N681</accession>
    <name>A0A096N681_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic translation initiation factor 2-alpha kinase 1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Hemin-sensitive initiation factor 2-alpha kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EIF2AK1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer. Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031521471.1">
        <property type="nucleotide sequence ID" value="XM_031665611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N681"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007974"/>
    <dbReference type="Ensembl" id="ENSPANT00000006425.3">
        <property type="protein sequence ID" value="ENSPANP00000007974.3"/>
        <property type="gene ID" value="ENSPANG00000004605.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014663"/>
    <dbReference type="CTD" id="27102"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157605"/>
    <dbReference type="HOGENOM" id="CLU_000288_134_1_1"/>
    <dbReference type="OMA" id="WDWIADR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004605">
        <property type="expression patterns" value="Expressed in bone marrow and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002526">
        <property type="term" value="P:acute inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140468">
        <property type="term" value="P:HRI-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030225">
        <property type="term" value="P:macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
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        <property type="term" value="P:negative regulation of hemoglobin biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phagocytosis"/>
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        <property type="term" value="P:protein localization to mitochondrion"/>
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        <property type="term" value="P:protoporphyrinogen IX metabolic process"/>
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        <property type="term" value="P:response to iron ion starvation"/>
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        <property type="term" value="P:translational initiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="STKc_EIF2AK1_HRI"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.200.20:FF:000380">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 alpha kinase 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative eukaryotic translation initiation factor 2-alpha kinase 1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CC_SR_Kinase"/>
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        <property type="entry name" value="HRI2_3H"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
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    <dbReference type="Pfam" id="PF22949">
        <property type="entry name" value="HRI2_3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="167"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040433"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042456"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007974.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="631" mass="71303" checksum="47B3DFF515F21BA7" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAF2</accession>
    <name>A0A096NAF2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Host cell factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">C1 factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HCFC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009196757.1">
        <property type="nucleotide sequence ID" value="XM_009198493.4"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000009660"/>
    <dbReference type="Ensembl" id="ENSPANT00000026085.3">
        <property type="protein sequence ID" value="ENSPANP00000009660.3"/>
        <property type="gene ID" value="ENSPANG00000024276.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100137257"/>
    <dbReference type="CTD" id="3054"/>
    <dbReference type="GeneTree" id="ENSGT00940000161383"/>
    <dbReference type="OMA" id="PDYGQMK"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024276">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NAF2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019046">
        <property type="term" value="P:release from viral latency"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000443">
        <property type="entry name" value="host cell factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000259">
        <property type="entry name" value="Host cell factor 1 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000008">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000015">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
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    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
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    <dbReference type="InterPro" id="IPR043536">
        <property type="entry name" value="HCF1/2"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059124">
        <property type="entry name" value="Kelch_HCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003:SF3">
        <property type="entry name" value="HOST CELL FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13854">
        <property type="entry name" value="Kelch_HCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1935"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1293"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1435"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2039"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1299"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009660.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2080" mass="213453" checksum="FEB4C1FF44074DC6" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NC94</accession>
    <name>A0A096NC94_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cysteine protease</fullName>
            <ecNumber evidence="18">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ATG4B</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine</text>
            <dbReference type="Rhea" id="RHEA:67576"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="Rhea" id="RHEA-COMP:17326"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172942"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:67577"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A096NC94"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010435"/>
    <dbReference type="Ensembl" id="ENSPANT00000016806.3">
        <property type="protein sequence ID" value="ENSPANP00000010435.2"/>
        <property type="gene ID" value="ENSPANG00000009064.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063000"/>
    <dbReference type="HOGENOM" id="CLU_021259_0_1_1"/>
    <dbReference type="OMA" id="CMIRSTQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009064">
        <property type="expression patterns" value="Expressed in amygdala and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NC94">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF39">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 18" id="KW-0645">Protease</keyword>
    <keyword evidence="12 18" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="20">
        <location>
            <begin position="142"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010435.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="515" mass="56314" checksum="E916C53A8CE153A5" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDE6</accession>
    <name>A0A096NDE6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PSMD4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NDE6"/>
    <dbReference type="SMR" id="A0A096NDE6"/>
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        <property type="protein sequence ID" value="ENSPANP00000010890.3"/>
        <property type="gene ID" value="ENSPANG00000010190.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064050"/>
    <dbReference type="HOGENOM" id="CLU_033293_0_1_1"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010190">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDE6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22297">
        <property type="entry name" value="PSMD4_RAZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.300.40:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PSMD4"/>
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        <property type="entry name" value="PSMD4_RAZUL-like"/>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
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            <end position="260"/>
        </location>
    </feature>
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            <end position="237"/>
        </location>
    </feature>
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            <begin position="238"/>
            <end position="253"/>
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    </feature>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010890.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="380" mass="41079" checksum="349CEDC533705229" modified="2022-05-25" version="3">MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEGERDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFA9</accession>
    <name>A0A096NFA9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Macrophage scavenger receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MSR1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
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        <property type="gene ID" value="ENSPANG00000016307.3"/>
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    <dbReference type="eggNOG" id="ENOG502QUW0">
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
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    <sequence length="483" mass="53256" checksum="28FF2E4615227BA2" modified="2022-05-25" version="2">MSQMLPVKMEPEYLKCEDQSHNQTRGEGASRSMEQWDPFRDQQEDVDSCSESVKFDARSMTALLPPNPKNSPPLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVGSTNADDITQSLTGKGNDSEAETRFQEVFMEHMSNMEKRIQHISDMEANLIDAEHFQNFSMATDQRFNDILLQLSTLFSSVQGHGNTIDEISKSLISLNTTLLDLQLNIEKLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPVGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTSFKKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVICRSLGYPGVQAVHKAAHFGQGTGPIWLNEVYCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NFJ6</accession>
    <name>A0A096NFJ6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C1orf74</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0739 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NFJ6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011694"/>
    <dbReference type="Ensembl" id="ENSPANT00000027526.3">
        <property type="protein sequence ID" value="ENSPANP00000011694.1"/>
        <property type="gene ID" value="ENSPANG00000000320.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101003552"/>
    <dbReference type="eggNOG" id="ENOG502RZ46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002240"/>
    <dbReference type="HOGENOM" id="CLU_1156081_0_0_1"/>
    <dbReference type="OMA" id="YPVTYWF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000320">
        <property type="expression patterns" value="Expressed in cornea and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027850">
        <property type="entry name" value="DUF4504"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31366">
        <property type="entry name" value="UPF0739 PROTEIN C1ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31366:SF2">
        <property type="entry name" value="UPF0739 PROTEIN C1ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14953">
        <property type="entry name" value="DUF4504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="270" mass="29666" checksum="DA78528E94A9DEB1" modified="2014-11-26" version="1">MLLLDLMSSPRPQLLVAAAQQTLGMGKRRSPPQAICLHLAGEVLAVARGLKPAVLYDCNCAGASELQSYLEELQGLGFLTFGLHILEIGENSLIVSPEHVCQHLEQVLLGTIAFVDVSSCQPHPSVCSLDQLQDLKALVAEIITHLQGLQRDLSPSAVSHSRLHSSDWNLCTVFGILLGYPVPYTFHLNQGDDNCLALTPLRVFTARISWLLGRPPILLYSFSVPESLFPGLRHILNTWEKDLRTRFRTQNDFADLSISSEIVTLPAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NG29</accession>
    <accession>A0A096NRH0</accession>
    <name>A0A096NG29_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calmodulin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CALM2</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908656.1">
        <property type="nucleotide sequence ID" value="XM_003908607.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NG29"/>
    <dbReference type="SMR" id="A0A096NG29"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011888"/>
    <dbReference type="Ensembl" id="ENSPANT00000007789.3">
        <property type="protein sequence ID" value="ENSPANP00000015640.2"/>
        <property type="gene ID" value="ENSPANG00000007712.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000011993.3">
        <property type="protein sequence ID" value="ENSPANP00000011888.2"/>
        <property type="gene ID" value="ENSPANG00000015474.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000043092.2">
        <property type="protein sequence ID" value="ENSPANP00000028250.1"/>
        <property type="gene ID" value="ENSPANG00000030529.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100997036"/>
    <dbReference type="KEGG" id="panu:100997036"/>
    <dbReference type="KEGG" id="panu:101007101"/>
    <dbReference type="CTD" id="805"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182980"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="9924840at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007712">
        <property type="expression patterns" value="Expressed in Ammon's horn and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NG29">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010856">
        <property type="term" value="F:adenylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010881">
        <property type="term" value="P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901844">
        <property type="term" value="P:regulation of cell communication by electrical coupling involved in cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011888.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="149" mass="16838" checksum="6B4BC3FCDE10727B" modified="2018-02-28" version="2">MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHV6</accession>
    <name>A0A096NHV6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein 629</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZNF629</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003916820.1">
        <property type="nucleotide sequence ID" value="XM_003916771.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NHV6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012554"/>
    <dbReference type="Ensembl" id="ENSPANT00000020982.3">
        <property type="protein sequence ID" value="ENSPANP00000012554.1"/>
        <property type="gene ID" value="ENSPANG00000016927.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017489"/>
    <dbReference type="KEGG" id="panu:101017489"/>
    <dbReference type="CTD" id="23361"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161909"/>
    <dbReference type="HOGENOM" id="CLU_002678_17_1_1"/>
    <dbReference type="OMA" id="CGDSFTE"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016927">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001767">
        <property type="entry name" value="Zinc finger protein 629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000431">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000520">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000751">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001090">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001188">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001198">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001202">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001827">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="601"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="786"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="872" mass="96677" checksum="DFE9B789E325B6AD" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIW2</accession>
    <name>A0A096NIW2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Transmembrane protease serine 2</fullName>
            <ecNumber evidence="18">3.4.21.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">TMPRSS2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>The enzyme cleaves angiotensin-converting enzyme 2 (EC 3.4.17.23) and cleaves influenzea A and B virus and coronavirus spike glycoproteins at arginine residues.</text>
            <dbReference type="EC" id="3.4.21.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">The catalytically active form interacts with ACE2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.122" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A096NIW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012910"/>
    <dbReference type="Ensembl" id="ENSPANT00000026609.3">
        <property type="protein sequence ID" value="ENSPANP00000012910.3"/>
        <property type="gene ID" value="ENSPANG00000015992.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155207"/>
    <dbReference type="HOGENOM" id="CLU_006842_19_2_1"/>
    <dbReference type="OMA" id="AQRKSWH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015992">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NIW2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098670">
        <property type="term" value="P:entry receptor-mediated virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046598">
        <property type="term" value="P:positive regulation of viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000152">
        <property type="entry name" value="Transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000027">
        <property type="entry name" value="Transmembrane serine protease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF30">
        <property type="entry name" value="TRANSMEMBRANE SERINE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 22" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="26">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="25">
        <location>
            <begin position="293"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012910.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="529" mass="57590" checksum="F7A1F9B0783BECAE" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMX8</accession>
    <name>A0A096NMX8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FAH</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="AlphaFoldDB" id="A0A096NMX8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000014338"/>
    <dbReference type="Ensembl" id="ENSPANT00000026684.3">
        <property type="protein sequence ID" value="ENSPANP00000014338.3"/>
        <property type="gene ID" value="ENSPANG00000015690.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008646"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015690">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NMX8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="17">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="16">
        <location>
            <begin position="125"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014338.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="423" mass="46899" checksum="60BB233F378187E5" modified="2022-05-25" version="3">MSFIPVAEDSDFPIHNLPYGVFSTRGDPRLRIGVAIGDQILDLSVIKHLFTGPVLSKHQDVFNQPVLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKRAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTISPWVVPMDALMPFALPNPEQDPRPLPYLCHDQPYTFDINLSVALKGEGMSQAATICKSNSKYMYWTMLQQLTHHSVNGCNLRPGDLLATGTISGPEPESFGSMLELSWKGTKPINLGNGQTRKFLLDGDEVIITGICGYCGNSMKTGHQEFESSVDEDLGHSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ12</accession>
    <name>A0A096NQ12_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pygopus family PHD finger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PYGO2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
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            <location evidence="1">Nucleus</location>
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    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="326"/>
            <end position="384"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <sequence length="405" mass="41127" checksum="5B95E953ADCAD748" modified="2014-11-26" version="1">MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLTEFAPPPTPMVDHLVASNPFEDDFGAPKVGGAAPPFLGSPVPFGGFRVQGGMAGQVPPGYGTGVGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQPLGQNFSPPSGQMMPGPVGGFGPMISPTMGQPPRAELGPPSLSQRFAQPGAPFGPSLQRPGQGLPSLPPNTSPFPGPDPGFPGPGGEDGGKPLNPPAPTAFPQEPHSGSPAAAVNGNQPSFPPNSSGRGGGTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACRSEVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVYIREGMGQLVAANDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQA0</accession>
    <name>A0A096NQA0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Microprocessor complex subunit DGCR8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DGCR8</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer; in absence of heme. Homodimer; the association with heme promotes its dimerization. Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8. The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region). Interacts with ILF3, NCL and DROSHA. Interacts with CPSF3 and ISY1; this interaction is in an RNA dependent manner. Interacts with PUS10; interaction promotes pri-miRNAs processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003905233.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021777073.1">
        <property type="nucleotide sequence ID" value="XM_021921381.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A096NQA0"/>
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        <property type="protein sequence ID" value="ENSPANP00000015194.2"/>
        <property type="gene ID" value="ENSPANG00000019987.3"/>
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    <dbReference type="GeneID" id="101024599"/>
    <dbReference type="KEGG" id="panu:101024599"/>
    <dbReference type="CTD" id="54487"/>
    <dbReference type="eggNOG" id="KOG4334">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000015977"/>
    <dbReference type="HOGENOM" id="CLU_017211_3_0_1"/>
    <dbReference type="OMA" id="PKKEWIM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
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    <dbReference type="Bgee" id="ENSPANG00000019987">
        <property type="expression patterns" value="Expressed in cornea and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQA0">
        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:double-stranded RNA binding"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:primary miRNA binding"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="term" value="F:protein-RNA adaptor activity"/>
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        <property type="term" value="P:DNA damage response"/>
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        <property type="term" value="P:positive regulation of pre-miRNA processing"/>
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        <property type="term" value="P:primary miRNA processing"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd19867">
        <property type="entry name" value="DSRM_DGCR8_rpt1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.20.70.10:FF:000018">
        <property type="entry name" value="DGCR8 microprocessor complex subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DGCR8, microprocessor complex subunit"/>
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        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DGCR8"/>
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        <property type="entry name" value="dsRBD_dom"/>
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    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
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    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="17">
        <location>
            <begin position="511"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="773" mass="86083" checksum="F8179A36A942CA57" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NT30</accession>
    <name>A0A096NT30_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RNF157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031513636.1">
        <property type="nucleotide sequence ID" value="XM_031657776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NT30"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016201"/>
    <dbReference type="Ensembl" id="ENSPANT00000003777.3">
        <property type="protein sequence ID" value="ENSPANP00000016201.3"/>
        <property type="gene ID" value="ENSPANG00000020057.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017940"/>
    <dbReference type="KEGG" id="panu:101017940"/>
    <dbReference type="CTD" id="114804"/>
    <dbReference type="eggNOG" id="KOG4265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009925"/>
    <dbReference type="HOGENOM" id="CLU_016631_2_0_1"/>
    <dbReference type="OMA" id="FLMCGGR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020057">
        <property type="expression patterns" value="Expressed in frontal cortex and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16817">
        <property type="entry name" value="mRING-HC-C3HC5_RNF157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase MGRN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF1">
        <property type="entry name" value="E3 UBIQUITIN LIGASE RNF157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016201.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="680" mass="73684" checksum="0CF10EE87BADEB55" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NX63</accession>
    <name>A0A096NX63_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neural retina-specific leucine zipper protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NRL</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with FIZ1; this interaction represses transactivation. Interacts (via the leucine-zipper domain) with CRX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901668.1">
        <property type="nucleotide sequence ID" value="XM_003901619.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209535.1">
        <property type="nucleotide sequence ID" value="XM_009211271.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209537.1">
        <property type="nucleotide sequence ID" value="XM_009211273.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209540.1">
        <property type="nucleotide sequence ID" value="XM_009211276.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031525042.1">
        <property type="nucleotide sequence ID" value="XM_031669182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031525043.1">
        <property type="nucleotide sequence ID" value="XM_031669183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NX63"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017653"/>
    <dbReference type="Ensembl" id="ENSPANT00000002228.3">
        <property type="protein sequence ID" value="ENSPANP00000017653.1"/>
        <property type="gene ID" value="ENSPANG00000015719.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014770"/>
    <dbReference type="KEGG" id="panu:101014770"/>
    <dbReference type="CTD" id="4901"/>
    <dbReference type="eggNOG" id="KOG4196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161862"/>
    <dbReference type="HOGENOM" id="CLU_063062_0_0_1"/>
    <dbReference type="OMA" id="SGDHAHF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015719">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043522">
        <property type="term" value="F:leucine zipper domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046548">
        <property type="term" value="P:retinal rod cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000071">
        <property type="entry name" value="Neural retina-specific leucine zipper protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013592">
        <property type="entry name" value="Maf_TF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF24">
        <property type="entry name" value="NEURAL RETINA-SPECIFIC LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08383">
        <property type="entry name" value="Maf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="18">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="237" mass="25984" checksum="E0CD36AC77CE066D" modified="2014-11-26" version="1">MALPPSPLAMEYVNDFDLMKFEVKREPSEGRPGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEALGLSPEEAMELLQGQGPVPVDGPHGYYPGSPEETGAQHIQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSSGPGSGELSHLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYG8</accession>
    <name>A0A096NYG8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FGF2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NYG8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018131"/>
    <dbReference type="Ensembl" id="ENSPANT00000006059.3">
        <property type="protein sequence ID" value="ENSPANP00000018131.2"/>
        <property type="gene ID" value="ENSPANG00000022787.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161583"/>
    <dbReference type="HOGENOM" id="CLU_081609_5_0_1"/>
    <dbReference type="OMA" id="KNGRESC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022787">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903672">
        <property type="term" value="P:positive regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000544">
        <property type="term" value="P:regulation of endothelial cell chemotaxis to fibroblast growth factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905330">
        <property type="term" value="P:regulation of morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23314">
        <property type="entry name" value="beta-trefoil_FGF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018131.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="288" mass="30857" checksum="A6830C600B3D3666" modified="2025-10-08" version="3">MVGVGGGDVEDVTPRPGGCQISRRGARGCNGIPGAAVWEAALPRRRPRRQPSLNPSSRAAGSPRTRGRRTEERPNGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGAAAPRAAPAARGPRQGPGGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYJ1</accession>
    <name>A0A096NYJ1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-tocopherol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TTPA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Monomer and homotetramer. Phosphatidylinositol 4,5-bisphosphate binding induces the formation of homotetramers. Phosphatidylinositol 3,4-bisphosphate is less efficient in inducing tetramerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031525446.1">
        <property type="nucleotide sequence ID" value="XM_031669586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYJ1"/>
    <dbReference type="Ensembl" id="ENSPANT00000002689.3">
        <property type="protein sequence ID" value="ENSPANP00000018154.3"/>
        <property type="gene ID" value="ENSPANG00000018418.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018953"/>
    <dbReference type="KEGG" id="panu:101018953"/>
    <dbReference type="CTD" id="7274"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159203"/>
    <dbReference type="HOGENOM" id="CLU_046597_1_2_1"/>
    <dbReference type="OMA" id="KQRVYMH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018418">
        <property type="expression patterns" value="Expressed in liver and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NYJ1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008431">
        <property type="term" value="F:vitamin E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042360">
        <property type="term" value="P:vitamin E metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051180">
        <property type="term" value="P:vitamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.20:FF:000003">
        <property type="entry name" value="Alpha-tocopherol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000002">
        <property type="entry name" value="Alpha-tocopherol transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF225">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="88"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018154.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="278" mass="31941" checksum="108016AFBAD263CC" modified="2022-05-25" version="3">MAEARFQPSRGPQLNALPDHSPLLQPGMAELRRRALEAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLQNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVREVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKKRIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZK6</accession>
    <name>A0A096NZK6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Cyclosome subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ANAPC4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 15">Belongs to the APC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009204884.1">
        <property type="nucleotide sequence ID" value="XM_009206620.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZK6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018527"/>
    <dbReference type="Ensembl" id="ENSPANT00000019338.3">
        <property type="protein sequence ID" value="ENSPANP00000018527.2"/>
        <property type="gene ID" value="ENSPANG00000019352.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011179"/>
    <dbReference type="CTD" id="29945"/>
    <dbReference type="eggNOG" id="KOG4640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004612"/>
    <dbReference type="HOGENOM" id="CLU_018724_0_0_1"/>
    <dbReference type="OMA" id="HCKLFVP"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019352">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZK6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001243">
        <property type="entry name" value="Anaphase-promoting complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056358">
        <property type="entry name" value="APC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017169">
        <property type="entry name" value="APC4_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23405">
        <property type="entry name" value="WD40_APC4_C-half"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037303">
        <property type="entry name" value="APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 15" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7 15" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="18">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="19">
        <location>
            <begin position="233"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 C-terminal half WD40" evidence="20">
        <location>
            <begin position="576"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="16">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="16">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037303-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018527.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="809" mass="92235" checksum="6D683118F96F67AF" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1J2</accession>
    <name>A0A096P1J2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">5,6-dihydroxyindole-2-carboxylic acid oxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Catalase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Tyrosinase-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">TYRP1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 indole-5,6-quinone-2-carboxylate + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:68388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:177869"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pigment biosynthesis; melanin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Monomer. Interacts with ATP7A. Interacts with SLC45A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Melanosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021783195.1">
        <property type="nucleotide sequence ID" value="XM_021927503.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P1J2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019217"/>
    <dbReference type="Ensembl" id="ENSPANT00000025630.3">
        <property type="protein sequence ID" value="ENSPANP00000019217.2"/>
        <property type="gene ID" value="ENSPANG00000025207.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016994"/>
    <dbReference type="KEGG" id="panu:101016994"/>
    <dbReference type="CTD" id="7306"/>
    <dbReference type="eggNOG" id="ENOG502QRNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155804"/>
    <dbReference type="HOGENOM" id="CLU_038693_1_0_1"/>
    <dbReference type="OMA" id="RSYKMEG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025207">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030669">
        <property type="term" value="C:clathrin-coated endocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043438">
        <property type="term" value="P:acetoacetic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048023">
        <property type="term" value="P:positive regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1280.10:FF:000001">
        <property type="entry name" value="5,6-dihydroxyindole-2-carboxylic acid oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF3">
        <property type="entry name" value="5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="24">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="25">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019217.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="560" mass="63439" checksum="2089F82FC8B16405" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2R6</accession>
    <name>A0A096P2R6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sex hormone-binding globulin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Sex steroid-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Testis-specific androgen-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SHBG</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021784378.1">
        <property type="nucleotide sequence ID" value="XM_021928686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2R6"/>
    <dbReference type="Ensembl" id="ENSPANT00000023161.3">
        <property type="protein sequence ID" value="ENSPANP00000019641.2"/>
        <property type="gene ID" value="ENSPANG00000024059.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009494"/>
    <dbReference type="CTD" id="6462"/>
    <dbReference type="eggNOG" id="KOG3927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154035"/>
    <dbReference type="HOGENOM" id="CLU_063172_0_0_1"/>
    <dbReference type="OMA" id="TEPWAFS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024059">
        <property type="expression patterns" value="Expressed in liver and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P2R6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000107">
        <property type="entry name" value="Sex hormone-binding globulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF3">
        <property type="entry name" value="SEX HORMONE-BINDING GLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0754">Steroid-binding</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014142424" description="Sex hormone-binding globulin" evidence="15">
        <location>
            <begin position="30"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="45"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019641.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="402" mass="43974" checksum="E423D5E0E7CC13F1" modified="2018-02-28" version="2">METRGPMATSRRLLLLLLLLLHHTHQGWALRPVLPTQRAQDPPAVHLSNGPGQEPAAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNYWAQLTVGAGPRLDDGRWHQVEVKMDGDSVLLKVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLFFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTHAEFNLQDIPQPHAEPWAFSLDLGLKQAAGSGHLLSLGTPENPSWLSLHLQDQKVVLSSGSGPGMDLPLVLGLPLQLKLSMSRVVLSQGPKMEVLALPPLGLASLLNLWAKPQGRLFLGALPGEDSSTSFCLHGLWAQGQRLDVDRALNRSHEIWTHSCPQSPGNGTDASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3T2</accession>
    <name>A0A096P3T2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sperm acrosome membrane-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SPACA3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ASTL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P3T2"/>
    <dbReference type="SMR" id="A0A096P3T2"/>
    <dbReference type="Ensembl" id="ENSPANT00000020956.3">
        <property type="protein sequence ID" value="ENSPANP00000020007.2"/>
        <property type="gene ID" value="ENSPANG00000023033.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1F5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161810"/>
    <dbReference type="HOGENOM" id="CLU_111620_0_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023033">
        <property type="expression patterns" value="Expressed in pyloric antrum and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002080">
        <property type="term" value="C:acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16897">
        <property type="entry name" value="LYZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000001">
        <property type="entry name" value="Lysozyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000974">
        <property type="entry name" value="Glyco_hydro_22_lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF25">
        <property type="entry name" value="SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00137">
        <property type="entry name" value="LYSOZYME"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014134211" description="Sperm acrosome membrane-associated protein 3" evidence="9">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="10">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020007.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="112" mass="12563" checksum="25A87F1067F1D9A6" modified="2018-02-28" version="2">MISALWGALLIRVCLAYFTSGFNTAAVDHEADGSTNNGIFQISSRRWCRNLTPNAPNMCGMYCSDLLNPNLKDTVICAMKITQEPQGLGYWEAWRHHCQGKDLTDWVDGCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P616</accession>
    <name>A0A096P616_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MORN repeat-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MORN4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MYO3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Stereocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009213367.1">
        <property type="nucleotide sequence ID" value="XM_009215103.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P616"/>
    <dbReference type="SMR" id="A0A096P616"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020791"/>
    <dbReference type="Ensembl" id="ENSPANT00000014223.3">
        <property type="protein sequence ID" value="ENSPANP00000020791.1"/>
        <property type="gene ID" value="ENSPANG00000021290.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015149"/>
    <dbReference type="KEGG" id="panu:101015149"/>
    <dbReference type="CTD" id="118812"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111173"/>
    <dbReference type="HOGENOM" id="CLU_113346_0_0_1"/>
    <dbReference type="OMA" id="FTRCDGM"/>
    <dbReference type="OrthoDB" id="406044at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021290">
        <property type="expression patterns" value="Expressed in suprachiasmatic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P616">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000011">
        <property type="entry name" value="MORN repeat-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000014">
        <property type="entry name" value="MORN repeat-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052315">
        <property type="entry name" value="MORN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46614">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46614:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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</entry>
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    <accession>A0A0A0MUJ1</accession>
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        <submittedName>
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        <name evidence="5" type="primary">MEIOSIN</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="expression patterns" value="Expressed in testis"/>
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        <property type="entry name" value="High mobility group box domain"/>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="638" mass="70211" checksum="47E039091E3F376F" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MX56</accession>
    <name>A0A0A0MX56_PAPAN</name>
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        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
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        <name evidence="9" type="primary">ANO8</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MX56"/>
    <dbReference type="Ensembl" id="ENSPANT00000007711.4">
        <property type="protein sequence ID" value="ENSPANP00000011542.3"/>
        <property type="gene ID" value="ENSPANG00000017975.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157019"/>
    <dbReference type="HOGENOM" id="CLU_006685_2_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017975">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MX56">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="237"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011542.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="581" mass="65437" checksum="9E8EC06B48513294" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MXK2</accession>
    <name>A0A0A0MXK2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Epidermal growth factor receptor kinase substrate 8-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Epidermal growth factor receptor pathway substrate 8-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EPS8L1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031515142.1">
        <property type="nucleotide sequence ID" value="XM_031659282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MXK2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018221"/>
    <dbReference type="Ensembl" id="ENSPANT00000003341.3">
        <property type="protein sequence ID" value="ENSPANP00000018221.3"/>
        <property type="gene ID" value="ENSPANG00000023646.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013698"/>
    <dbReference type="CTD" id="54869"/>
    <dbReference type="eggNOG" id="KOG3557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158125"/>
    <dbReference type="HOGENOM" id="CLU_014510_0_0_1"/>
    <dbReference type="OMA" id="NIIMADV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023646">
        <property type="expression patterns" value="Expressed in esophagus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042608">
        <property type="term" value="F:T cell receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09540">
        <property type="entry name" value="SAM_EPS8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000023">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000071">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000261">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF19">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018221.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="718" mass="79400" checksum="7BA1E941FBE549FE" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LDR7</accession>
    <name>A0A2I3LDR7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TEC</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3LDR7"/>
    <dbReference type="Ensembl" id="ENSPANT00000051378.2">
        <property type="protein sequence ID" value="ENSPANP00000021585.2"/>
        <property type="gene ID" value="ENSPANG00000016343.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155951"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016343">
        <property type="expression patterns" value="Expressed in bone marrow and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LDR7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010543">
        <property type="term" value="P:regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10396">
        <property type="entry name" value="SH2_Tec_Itk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11905">
        <property type="entry name" value="SH3_Tec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000151">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000041">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR035572">
        <property type="entry name" value="Tec_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
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    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="332"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021585.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="572" mass="66414" checksum="11482F6349D0674D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGB4</accession>
    <name>A0A2I3LGB4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LGB4"/>
    <dbReference type="SMR" id="A0A2I3LGB4"/>
    <dbReference type="Ensembl" id="ENSPANT00000045424.2">
        <property type="protein sequence ID" value="ENSPANP00000022500.2"/>
        <property type="gene ID" value="ENSPANG00000037028.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154902"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012131">
        <property type="expression patterns" value="Expressed in esophagus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LGB4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043034">
        <property type="term" value="C:costamere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000106">
        <property type="entry name" value="Neuroblast differentiation-associated protein AHNAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052082">
        <property type="entry name" value="Myelin_sheath_structural"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23348:SF41">
        <property type="entry name" value="NEUROBLAST DIFFERENTIATION-ASSOCIATED PROTEIN AHNAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23348">
        <property type="entry name" value="PERIAXIN/AHNAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022500.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="150" mass="16315" checksum="ADD56F3632BAC827" modified="2022-05-25" version="2">MEKEEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVTQNSPAARTGVVKEGDQIVGATIYFDNLQSDEVTQLLNTMGHHTVGLKLHRKGDRSPEPGQTWTREVFSSRSSEVVLNTPQPSALECKDQNKQKEASSQAGAVSISTPNAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGE5</accession>
    <name>A0A2I3LGE5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Progesterone immunomodulatory binding factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIBF1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LGE5"/>
    <dbReference type="Ensembl" id="ENSPANT00000037646.2">
        <property type="protein sequence ID" value="ENSPANP00000022535.2"/>
        <property type="gene ID" value="ENSPANG00000007392.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015293"/>
    <dbReference type="OMA" id="KCERDTF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024153">
        <property type="expression patterns" value="Expressed in esophagus and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LGE5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:protein localization to centrosome"/>
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        <property type="entry name" value="KLF5_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="PIBF1"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROGESTERONE-INDUCED-BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="949"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="78"/>
            <end position="155"/>
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    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="209"/>
            <end position="239"/>
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    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="264"/>
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    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="474"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="595"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022535.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1111" mass="129435" checksum="36502CA16BC8A148" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LHZ9</accession>
    <name>A0A2I3LHZ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Atlastin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ATL1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. May also regulate more or less directly Golgi biogenesis. Indirectly regulates axonal development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Monomeric and homodimeric. The homodimer, transiently formed by two molecules on opposing membranes, is the active form mediating ER membrane fusion. Interacts with REEP1, REEP5, RTN3 and RTN4 (via the transmembrane region); these proteins are involved in endoplasmic reticulum tubular network organization. Interacts with ZFYVE27; both proteins are involved in endoplasmic reticulum tubular network organization. Interacts with ARL6IP1; both proteins are involved in endoplasmic reticulum tubular network organization. Interacts with SPAST; the interaction is direct, could recruit SPAST to Golgi membranes. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). May interact with TMED2. Interacts with CPT1C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_009211513.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796891.1">
        <property type="nucleotide sequence ID" value="XM_021941199.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LHZ9"/>
    <dbReference type="SMR" id="A0A2I3LHZ9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000023134"/>
    <dbReference type="Ensembl" id="ENSPANT00000032502.2">
        <property type="protein sequence ID" value="ENSPANP00000023134.1"/>
        <property type="gene ID" value="ENSPANG00000014239.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101006657"/>
    <dbReference type="KEGG" id="panu:101006657"/>
    <dbReference type="CTD" id="51062"/>
    <dbReference type="GeneTree" id="ENSGT00940000158704"/>
    <dbReference type="OMA" id="GFIHNIW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Bgee" id="ENSPANG00000014239">
        <property type="expression patterns" value="Expressed in Ammon's horn and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LHZ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140523">
        <property type="term" value="F:GTPase-dependent fusogenic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990809">
        <property type="term" value="P:endoplasmic reticulum tubular network membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
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        <property type="entry name" value="Guanylate-bd_C_sf"/>
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        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="25">
        <location>
            <begin position="64"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00093499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="558" mass="63515" checksum="4B3EDB8B2B091886" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LKA5</accession>
    <name>A0A2I3LKA5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centriolar satellite-associated tubulin polyglutamylase complex regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSTPP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to alpha-tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CSTPP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LKA5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000023939"/>
    <dbReference type="Ensembl" id="ENSPANT00000033084.2">
        <property type="protein sequence ID" value="ENSPANP00000023939.1"/>
        <property type="gene ID" value="ENSPANG00000001891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000322"/>
    <dbReference type="CTD" id="79096"/>
    <dbReference type="GeneTree" id="ENSGT00390000012935"/>
    <dbReference type="OMA" id="KATPHNR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001891">
        <property type="expression patterns" value="Expressed in arcuate nucleus of hypothalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LKA5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061523">
        <property type="term" value="P:cilium disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061635">
        <property type="term" value="P:regulation of protein complex stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22959">
        <property type="entry name" value="DD_C11orf49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038968">
        <property type="entry name" value="CSTPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252:SF1">
        <property type="entry name" value="CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252">
        <property type="entry name" value="UPF0705 PROTEIN C11ORF49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000023939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="337" mass="38225" checksum="BC968234E9BBCC3A" modified="2018-02-28" version="1">MLSPERLALPDYEYLAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFWRCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVIVPTSSSGQHRQRPALGEAGMLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHHGINQALGALPDKGDLMHDPAMDEELERLLLPFFRLAQVPGLVNSITASPEASCLPSRTPPRVGSPWRPLHHSRKVDGESDGSTEETDESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LLM1</accession>
    <name>A0A2I3LLM1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LLM1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024326"/>
    <dbReference type="Ensembl" id="ENSPANT00000051585.2">
        <property type="protein sequence ID" value="ENSPANP00000024326.2"/>
        <property type="gene ID" value="ENSPANG00000038775.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271826"/>
    <dbReference type="OMA" id="RTPWMEQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000036111">
        <property type="expression patterns" value="Expressed in spleen and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
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        <property type="term" value="P:immune response"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
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    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
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    <dbReference type="FunFam" id="3.30.500.10:FF:000013">
        <property type="entry name" value="Histocompatibility 2, blastocyst"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF164">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199443" description="Ig-like domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024326.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="248" mass="27609" checksum="2E0FB56727565A8D" modified="2022-05-25" version="2">MALGTLLLLLSALTKTWAGSHSLKYFHTSVSRPGRGGPRFISVGYVDDTQFVRYDSDAASPRMEPRALWMEQEGPEYWDQETRSARDTAQTFRVNLDTLRGYYNQSEAEPPKTHVTHHPVSDHEATLRCWALGFYPAEITVTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQSTIPIVGIIAGLVLLGAVVTGAVVAAVMWRRKSSAGEGVRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LRP5</accession>
    <name>A0A2I3LRP5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoprotein M6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPM6B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin proteolipid protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031516383.1">
        <property type="nucleotide sequence ID" value="XM_031660523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LRP5"/>
    <dbReference type="SMR" id="A0A2I3LRP5"/>
    <dbReference type="Ensembl" id="ENSPANT00000044970.2">
        <property type="protein sequence ID" value="ENSPANP00000026151.2"/>
        <property type="gene ID" value="ENSPANG00000013390.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025497"/>
    <dbReference type="CTD" id="2824"/>
    <dbReference type="GeneTree" id="ENSGT00390000006915"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013390">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LRP5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051612">
        <property type="term" value="P:negative regulation of serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018237">
        <property type="entry name" value="Myelin_PLP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF10">
        <property type="entry name" value="NEURONAL MEMBRANE GLYCOPROTEIN M6-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00214">
        <property type="entry name" value="MYELINPLP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00002">
        <property type="entry name" value="PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00575">
        <property type="entry name" value="MYELIN_PLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01004">
        <property type="entry name" value="MYELIN_PLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026151.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="305" mass="33538" checksum="69BE0DAA9B35C3A0" modified="2022-05-25" version="2">MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LWD3</accession>
    <name>A0A2I3LWD3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LWD3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000027774"/>
    <dbReference type="Ensembl" id="ENSPANT00000038381.2">
        <property type="protein sequence ID" value="ENSPANP00000027774.2"/>
        <property type="gene ID" value="ENSPANG00000029852.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000186656"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029852">
        <property type="expression patterns" value="Expressed in bone marrow and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05772">
        <property type="entry name" value="IgC1_SIRP_domain_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16085">
        <property type="entry name" value="IgC1_SIRP_domain_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16097">
        <property type="entry name" value="IgV_SIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000490">
        <property type="entry name" value="Signal-regulatory protein beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000295">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000454">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051755">
        <property type="entry name" value="Ig-like_CS_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19971">
        <property type="entry name" value="SIGNAL-REGULATORY PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035265120" description="Ig-like domain-containing protein" evidence="11">
        <location>
            <begin position="30"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="146"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="251"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027774.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="397" mass="43075" checksum="2339E71518FC49C8" modified="2022-05-25" version="2">MPIPASWPHLPGPFLLMNLLLGGLPGVLGEEELQVIQPEKSVSVTAGESATLNCTVTSLIPVGPIQWFRGAGPGRELIYGQKEGHFPRVTIVSDPTKRNNLDFSIRISNIAPADAGTYYCVKFRKGSPDVELKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVCFTCESHGFSPKDITLQWFKNGNELSDFQTSVDPAVKSVSYSIRSTARVVLTRRDVHSQVICEVAHVTLQGDPLRGTANLSEAIRVPPFLEVTQQSMRAENQANITCQVSNFYPQRLLLTWLENGNVSQTETASTLTENKDGTYNWTSWLLVNTCAHRDNVVLTCQVEHDGQPAVSKSHTLEISAHQKEQDSNVTHGLALAPTAPLLVALLLGPKVLLVVGVSAVYICWKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M0V8</accession>
    <name>A0A2I3M0V8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nectin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Herpes virus entry mediator C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Nectin cell adhesion molecule 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Poliovirus receptor-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NECTIN1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Involved in synaptogegesis. Has some neurite outgrowth-promoting activity. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Required for enamel mineralization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN3 and with NECTIN4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via cytoplasmic domain) with AFDN (via PDZ domain); this interaction recruits NECTIN1 to cadherin-based adherens junctions and provides a connection with the actin cytoskeleton. Interacts with integrin alphaV/beta3. Interacts (via Ig-like C2-type domain 2) with FGFR1, FGFR2 and FGFR3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003910886.1">
        <property type="nucleotide sequence ID" value="XM_003910837.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M0V8"/>
    <dbReference type="Ensembl" id="ENSPANT00000037231.2">
        <property type="protein sequence ID" value="ENSPANP00000029337.2"/>
        <property type="gene ID" value="ENSPANG00000003691.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010547"/>
    <dbReference type="KEGG" id="panu:101010547"/>
    <dbReference type="CTD" id="5818"/>
    <dbReference type="GeneTree" id="ENSGT00940000156933"/>
    <dbReference type="OMA" id="CVVNYHM"/>
    <dbReference type="OrthoDB" id="8718740at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003691">
        <property type="expression patterns" value="Expressed in cornea and 49 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M0V8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098631">
        <property type="term" value="F:cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902414">
        <property type="term" value="P:protein localization to cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05890">
        <property type="entry name" value="IgC1_2_Nectin-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05886">
        <property type="entry name" value="IgV_1_Nectin-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000268">
        <property type="entry name" value="Nectin cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000304">
        <property type="entry name" value="Nectin cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000427">
        <property type="entry name" value="Nectin cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041850">
        <property type="entry name" value="Nectin-1_Ig2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041849">
        <property type="entry name" value="Nectin-1_IgV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF69">
        <property type="entry name" value="NECTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-1183">Host cell receptor for virus entry</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 24" id="KW-0732">Signal</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158576" description="Nectin-1" evidence="24">
        <location>
            <begin position="31"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="402"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00084118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="519" mass="57286" checksum="C0BD1530D0526F99" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M1S1</accession>
    <name>A0A2I3M1S1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADH1A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3M1S1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000029657"/>
    <dbReference type="Ensembl" id="ENSPANT00000053444.2">
        <property type="protein sequence ID" value="ENSPANP00000029657.2"/>
        <property type="gene ID" value="ENSPANG00000031637.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155234"/>
    <dbReference type="OMA" id="EPWYCFA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031637">
        <property type="expression patterns" value="Expressed in liver and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006068">
        <property type="term" value="P:ethanol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048545">
        <property type="term" value="P:response to steroid hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033574">
        <property type="term" value="P:response to testosterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08299">
        <property type="entry name" value="alcohol_DH_class_I_II_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="15"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000029657.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="370" mass="39264" checksum="CB88E432ECF0F616" modified="2022-05-25" version="2">MPSQVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMAAVGICSTDDHVVSGNMVTPLPVILGHEAAGIVESVGEGVTTVEPGDKVIPLVVPQCGKCRIFMLLSHAFVCLCIALPSVSNPRGTLQDGTSRFTCRGKPIHHFLGVSSFSQYTVVDENAVAKIDAASPMEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIIGVPPNSQNLSINPMLLLIGRTWKGAIFGGYKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M3D2</accession>
    <name>A0A2I3M3D2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TANC2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TANC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017806333.1">
        <property type="nucleotide sequence ID" value="XM_017950844.3"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000030213"/>
    <dbReference type="Ensembl" id="ENSPANT00000038277.2">
        <property type="protein sequence ID" value="ENSPANP00000030213.1"/>
        <property type="gene ID" value="ENSPANG00000021044.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101019137"/>
    <dbReference type="CTD" id="26115"/>
    <dbReference type="GeneTree" id="ENSGT00940000156447"/>
    <dbReference type="OMA" id="MTQRPYQ"/>
    <dbReference type="OrthoDB" id="5958958at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021044">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M3D2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061001">
        <property type="term" value="P:regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000022">
        <property type="entry name" value="protein TANC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000036">
        <property type="entry name" value="protein TANC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000044">
        <property type="entry name" value="Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
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        <property type="entry name" value="WH_TANC1/2"/>
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        <property type="entry name" value="PROTEIN TANC2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
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        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR-like"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3 9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="11">
        <location>
            <begin position="672"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="12">
        <location>
            <begin position="768"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1023"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1238"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1328"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1375"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1409"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="516"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1456"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1512"/>
            <end position="1670"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1779"/>
            <end position="1805"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1870"/>
            <end position="1890"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1908"/>
            <end position="1930"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2055"/>
            <end position="2077"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="505"/>
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    </feature>
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            <begin position="1463"/>
            <end position="1474"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1556"/>
            <end position="1585"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1640"/>
            <end position="1659"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1870"/>
            <end position="1885"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038259"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2077" mass="229103" checksum="26735F9486444153" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7E0</accession>
    <name>A0A2I3M7E0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">High mobility group protein B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="34">High mobility group protein 1</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="39" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="35">In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMGB family.</text>
    </comment>
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        <property type="gene ID" value="ENSPANG00000007200.3"/>
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        <property type="component" value="Chromosome 15"/>
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    <dbReference type="Bgee" id="ENSPANG00000007200">
        <property type="expression patterns" value="Expressed in duodenum and 66 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:endosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032732">
        <property type="term" value="P:positive regulation of interleukin-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051052">
        <property type="term" value="P:regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001936">
        <property type="term" value="P:regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21979">
        <property type="entry name" value="HMG-box_HMGB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000006">
        <property type="entry name" value="High mobility group protein B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000015">
        <property type="entry name" value="high mobility group protein B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017967">
        <property type="entry name" value="HMG_boxA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF35">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00353">
        <property type="entry name" value="HMG_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0007">Acetylation</keyword>
    <keyword evidence="26" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="20" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="23" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="28" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="29" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="31" id="KW-0234">DNA repair</keyword>
    <keyword evidence="25 36" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0391">Immunity</keyword>
    <keyword evidence="30" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="16" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="27" id="KW-0472">Membrane</keyword>
    <keyword evidence="32 36" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-0558">Oxidation</keyword>
    <keyword evidence="15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="HMG box" evidence="38">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="38">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="36">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="36">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="37">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="37">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00023865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00030692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00058370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="159" mass="18474" checksum="C9EA438343E7F52F" modified="2018-02-28" version="1">MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M899</accession>
    <name>A0A2I3M899_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rab3 GDP/GTP exchange factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rab3 GDP/GTP exchange protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MADD</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (via death domain) with TNFRSF1A (via death domain). Interacts with PIDD1. Interacts with YWHAZ. Interacts (via death domain) with KIF1B; links the motor KIF1B to Rab3-carrying vesicles in anterograde synaptic vesicle transport. Interacts with KIF1A. Interacts (via uDENN domain) with RAB3A, RAB3B, RAB3C and RAB3D; the GTP-bound form of the Rab proteins is preferred for interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
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            <begin position="108"/>
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            <begin position="128"/>
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        <location>
            <begin position="142"/>
            <end position="157"/>
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            <begin position="158"/>
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    <sequence length="1588" mass="176674" checksum="190BE3A73D9E6689" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M8T3</accession>
    <name>A0A2I3M8T3_PAPAN</name>
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        <recommendedName>
            <fullName evidence="13">Leucine-rich repeat and fibronectin type-III domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
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        <name evidence="18" type="primary">LRFN5</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LRFN family.</text>
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        <property type="nucleotide sequence ID" value="XM_017961144.3"/>
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    <dbReference type="RefSeq" id="XP_021796848.1">
        <property type="nucleotide sequence ID" value="XM_021941156.2"/>
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        <property type="protein sequence ID" value="ENSPANP00000032053.2"/>
        <property type="gene ID" value="ENSPANG00000014242.3"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Bgee" id="ENSPANG00000014242">
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="IgI_SALM5_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine rich repeat and fibronectin type III domain containing 5"/>
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        <property type="entry name" value="Immunoglobulins"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF10">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035274746" description="Leucine-rich repeat and fibronectin type-III domain-containing protein 5" evidence="16">
        <location>
            <begin position="18"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="287"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="616"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="719" mass="79407" checksum="B8717C7B568265E2" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MAI9</accession>
    <name>A0A2I3MAI9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6.</text>
    </comment>
    <comment type="function">
        <text evidence="7">In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity.</text>
    </comment>
    <comment type="function">
        <text evidence="8">In the plasma membrane, is involved in IGFBP6-induced cell migration. Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ESR1, HDAC1 and HDAC5. Interacts with ZNF703. Interacts with STOML2. Interacts with ARFGEF3. Interacts with SPHK2. Interacts with COX4I1; the interaction associates PHB2 with COX. Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction is direct and upon mitochondrial depolarization and proteasome-dependent outer membrane rupture. Interacts with IGFBP6 (via C-terminal domain). Interacts with CLPB. Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40. Interacts with AFG3L2. Interacts with DNAJC19. Interacts with AKT2; this interaction may be important for myogenic differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MAI9"/>
    <dbReference type="Ensembl" id="ENSPANT00000039968.2">
        <property type="protein sequence ID" value="ENSPANP00000032650.2"/>
        <property type="gene ID" value="ENSPANG00000029448.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183070"/>
    <dbReference type="OMA" id="RTKAHQV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029448">
        <property type="expression patterns" value="Expressed in aorta and 29 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="13">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032650.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="270" mass="30183" checksum="9FE75D56CB5C168F" modified="2022-05-25" version="2">MAQNLKDLAGRLSAGPRGMGTALKLLLGTSAMAYGVRESVFTVEGGHRAIFFNWISGVQQDTILVEGLHFRIPWFQYPIIYDIQARSRKISFPIGSKDLQMVNISLQVLSRPNAQELPMLPSIVNEMLKSVVAKFNASQLITQRARVSLLIRRELTERAKDFSLILDDVAITELSCSREYTAAVEAKQVAQQEVHQAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIYHAMVPHTGPLNPSWIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGN9</accession>
    <name>A0A2I3MGN9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RUN domain-containing protein 3B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RUNDC3B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with RAP2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUNDC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009201775.1">
        <property type="nucleotide sequence ID" value="XM_009203511.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MGN9"/>
    <dbReference type="SMR" id="A0A2I3MGN9"/>
    <dbReference type="Ensembl" id="ENSPANT00000035657.2">
        <property type="protein sequence ID" value="ENSPANP00000034957.2"/>
        <property type="gene ID" value="ENSPANG00000020857.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007517"/>
    <dbReference type="CTD" id="154661"/>
    <dbReference type="GeneTree" id="ENSGT00940000159175"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020857">
        <property type="expression patterns" value="Expressed in putamen and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MGN9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd17700">
        <property type="entry name" value="RUN_RUNDC3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047339">
        <property type="entry name" value="RUN_RUNDC3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047340">
        <property type="entry name" value="RUNDC3A_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46251">
        <property type="entry name" value="RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46251:SF1">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="6">
        <location>
            <begin position="57"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034957.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="407" mass="45124" checksum="17A2100BA4A1A727" modified="2022-05-25" version="2">MASRSLGGLSGIRGGGGGGGKKSLSSRNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MJS2</accession>
    <name>A0A2I3MJS2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IQ motif and Sec7 domain ArfGEF 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IQSEC2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRAG family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000042291.2">
        <property type="protein sequence ID" value="ENSPANP00000035984.2"/>
        <property type="gene ID" value="ENSPANG00000007224.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159667"/>
    <dbReference type="OMA" id="CQTRRVQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007224">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MJS2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
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            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00006248"/>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50190"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035984.2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="1480" mass="162609" checksum="7BFFB6DAC3D0F740" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MN07</accession>
    <name>A0A2I3MN07_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Phospholipase A2</fullName>
            <ecNumber evidence="4 15">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PLA2G4B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40427"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73003"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="4 15"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MN07"/>
    <dbReference type="STRING" id="9555.ENSPANP00000036996"/>
    <dbReference type="Ensembl" id="ENSPANT00000045317.2">
        <property type="protein sequence ID" value="ENSPANP00000036996.2"/>
        <property type="gene ID" value="ENSPANG00000030855.2"/>
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    <dbReference type="GeneTree" id="ENSGT01030000234606"/>
    <dbReference type="OMA" id="FRFRIHS"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Bgee" id="ENSPANG00000030855">
        <property type="expression patterns" value="Expressed in cornea and 65 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:calcium-dependent phospholipid binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="C2_cPLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07201">
        <property type="entry name" value="cPLA2_Grp-IVB-IVD-IVE-IVF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000030">
        <property type="entry name" value="Phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000002">
        <property type="entry name" value="Phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041847">
        <property type="entry name" value="C2_cPLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040723">
        <property type="entry name" value="cPLA2_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF32">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18695">
        <property type="entry name" value="cPLA2_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="17">
        <location>
            <begin position="246"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036996.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="781" mass="87871" checksum="3ABFCDB9CAD99456" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MPT6</accession>
    <name>A0A2I3MPT6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pro-cathepsin H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CTSH</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Important for the overall degradation of proteins in lysosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.</text>
            <dbReference type="EC" id="3.4.22.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901328.1">
        <property type="nucleotide sequence ID" value="XM_003901279.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MPT6"/>
    <dbReference type="Ensembl" id="ENSPANT00000042201.2">
        <property type="protein sequence ID" value="ENSPANP00000037636.2"/>
        <property type="gene ID" value="ENSPANG00000015769.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005151"/>
    <dbReference type="KEGG" id="panu:101005151"/>
    <dbReference type="CTD" id="1512"/>
    <dbReference type="GeneTree" id="ENSGT00940000160227"/>
    <dbReference type="OMA" id="TCKFQPQ"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015769">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MPT6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097208">
        <property type="term" value="C:alveolar lamellar body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008656">
        <property type="term" value="F:cysteine-type endopeptidase activator activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030108">
        <property type="term" value="F:HLA-A specific activating MHC class I receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070324">
        <property type="term" value="F:thyroid hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010815">
        <property type="term" value="P:bradykinin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097067">
        <property type="term" value="P:cellular response to thyroid hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060448">
        <property type="term" value="P:dichotomous subdivision of terminal units involved in lung branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002764">
        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010813">
        <property type="term" value="P:neuropeptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043129">
        <property type="term" value="P:surfactant homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001913">
        <property type="term" value="P:T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000074">
        <property type="entry name" value="Pro-cathepsin H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035251330" description="Pro-cathepsin H" evidence="15">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="17">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="16">
        <location>
            <begin position="116"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037636.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="335" mass="37362" checksum="6B8B95A30CCE4318" modified="2022-05-25" version="2">MWVTLPLLCAGAWLLGAPVCGAAELSVNSLEKFHFKSWMSKHHKTYSTEEYHHRMQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSMDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGDCKFRPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYKTGIYSSTSCHKTPDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MZB9</accession>
    <name>A0A2I3MZB9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="19">6.2.1.15</ecNumber>
            <ecNumber evidence="19">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Acyl-CoA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACSL5</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16 19">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17 19">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14 19">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15 19">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 19">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18 19">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 19">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="19"/>
    <dbReference type="EC" id="6.2.1.3" evidence="19"/>
    <dbReference type="RefSeq" id="XP_021799764.2">
        <property type="nucleotide sequence ID" value="XM_021944072.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508446.1">
        <property type="nucleotide sequence ID" value="XM_031652586.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508447.1">
        <property type="nucleotide sequence ID" value="XM_031652587.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508448.1">
        <property type="nucleotide sequence ID" value="XM_031652588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MZB9"/>
    <dbReference type="Ensembl" id="ENSPANT00000048964.2">
        <property type="protein sequence ID" value="ENSPANP00000041072.2"/>
        <property type="gene ID" value="ENSPANG00000020795.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025657"/>
    <dbReference type="KEGG" id="panu:101025657"/>
    <dbReference type="CTD" id="51703"/>
    <dbReference type="GeneTree" id="ENSGT00940000156651"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020795">
        <property type="expression patterns" value="Expressed in duodenum and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MZB9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010747">
        <property type="term" value="P:positive regulation of long-chain fatty acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000006">
        <property type="entry name" value="long-chain-fatty-acid--CoA ligase 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 19" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="101"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000041072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="683" mass="76190" checksum="3A6BDDADDB0726C1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N0D3</accession>
    <name>A0A2I3N0D3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease</fullName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RNASEH2A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="RefSeq" id="XP_003915042.1">
        <property type="nucleotide sequence ID" value="XM_003914993.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N0D3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000041336"/>
    <dbReference type="Ensembl" id="ENSPANT00000034127.2">
        <property type="protein sequence ID" value="ENSPANP00000041336.1"/>
        <property type="gene ID" value="ENSPANG00000034495.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101004436"/>
    <dbReference type="KEGG" id="panu:101004436"/>
    <dbReference type="CTD" id="10535"/>
    <dbReference type="GeneTree" id="ENSGT00390000010768"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034495">
        <property type="expression patterns" value="Expressed in ascending colon and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000041336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="300" mass="33550" checksum="5DAEBE65DCEB7BB6" modified="2018-02-28" version="1">MDLSELERDNTGRCRLSSPVPAACRKEPCVLGVDEAGRGPVLGPMVYAICYCPLSHLADLEALKVADSKTLLESERERLFAKMEENRDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASICAKVARDQAVKKWKFVEKLQDSDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKEAEDVIWEDSTPEDQEGLRKITSYFLNEGSQARPRTSHRYFLERGLESATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N587</accession>
    <name>A0A2I3N587_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM2 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TM2D2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902718.1">
        <property type="nucleotide sequence ID" value="XM_003902669.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N587"/>
    <dbReference type="STRING" id="9555.ENSPANP00000043051"/>
    <dbReference type="Ensembl" id="ENSPANT00000053198.2">
        <property type="protein sequence ID" value="ENSPANP00000043051.1"/>
        <property type="gene ID" value="ENSPANG00000034721.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101006088"/>
    <dbReference type="KEGG" id="panu:101006088"/>
    <dbReference type="CTD" id="83877"/>
    <dbReference type="GeneTree" id="ENSGT00730000111181"/>
    <dbReference type="OMA" id="PIDHKGN"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034721">
        <property type="expression patterns" value="Expressed in thyroid gland and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014143584" description="TM2 domain-containing protein 2" evidence="11">
        <location>
            <begin position="36"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="12">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="214" mass="22907" checksum="86624AE910402ACC" modified="2018-02-28" version="1">MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAHPEGPGGAANWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NA74</accession>
    <name>A0A2I3NA74_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPP2R2C</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021793932.2">
        <property type="nucleotide sequence ID" value="XM_021938240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NA74"/>
    <dbReference type="SMR" id="A0A2I3NA74"/>
    <dbReference type="Ensembl" id="ENSPANT00000040954.2">
        <property type="protein sequence ID" value="ENSPANP00000044918.2"/>
        <property type="gene ID" value="ENSPANG00000010162.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020551"/>
    <dbReference type="CTD" id="5522"/>
    <dbReference type="GeneTree" id="ENSGT00950000182864"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010162">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 59 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NA74">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044918.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="447" mass="51515" checksum="DB002C2384686BBD" modified="2022-05-25" version="2">MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NBE6</accession>
    <name>A0A2I3NBE6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein eL19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">60S ribosomal protein L19</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3NBE6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000045374"/>
    <dbReference type="Ensembl" id="ENSPANT00000021588.3">
        <property type="protein sequence ID" value="ENSPANP00000045374.2"/>
        <property type="gene ID" value="ENSPANG00000007069.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012628"/>
    <dbReference type="OMA" id="RAQCRKN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007069">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0164">Citrullination</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="11">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045374.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="196" mass="23291" checksum="866D075961F81527" modified="2022-05-25" version="2">MSMLRLQKRLASSVLRCGKKKVWLDSNETNEIANANSRQQIRKLIKDGLIICKPVTVHSRAQCRKNTLARRKGRHMGTGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKAHKKLLADQAEARRSKTKEARKRCEERLQAKKEEIIKTLSKEEETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MV39</accession>
    <name>A0A8I5MV39_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5MV39"/>
    <dbReference type="Ensembl" id="ENSPANT00000077137.1">
        <property type="protein sequence ID" value="ENSPANP00000048291.1"/>
        <property type="gene ID" value="ENSPANG00000046954.1"/>
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    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="SMINIDA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
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    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048291.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
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            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1L1</accession>
    <name>A0A8I5N1L1_PAPAN</name>
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        <submittedName>
            <fullName evidence="6">Ubinuclein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBN2</name>
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    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the ubinuclein family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_021936319.2"/>
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        <property type="protein sequence ID" value="ENSPANP00000052000.1"/>
        <property type="gene ID" value="ENSPANG00000016309.3"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF10">
        <property type="entry name" value="UBINUCLEIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="4">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="5">
        <location>
            <begin position="448"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="798"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="863"/>
            <end position="896"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="964"/>
            <end position="989"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1201"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1292"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="573"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="704"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="806"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1018"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1043"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1078"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1147"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1157"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1330" mass="144249" checksum="53E485A1D53F430E" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1X4</accession>
    <name>A0A8I5N1X4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SKI like proto-onco</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SKIL</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894895.1">
        <property type="nucleotide sequence ID" value="XM_003894846.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N1X4"/>
    <dbReference type="Ensembl" id="ENSPANT00000076831.1">
        <property type="protein sequence ID" value="ENSPANP00000053124.1"/>
        <property type="gene ID" value="ENSPANG00000009806.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024514"/>
    <dbReference type="KEGG" id="panu:101024514"/>
    <dbReference type="CTD" id="6498"/>
    <dbReference type="GeneTree" id="ENSGT00940000158435"/>
    <dbReference type="OMA" id="HAHRMEE"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001825">
        <property type="term" value="P:blastocyst formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070306">
        <property type="term" value="P:lens fiber cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002260">
        <property type="term" value="P:lymphocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902043">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902231">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21084">
        <property type="entry name" value="DHD_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000002">
        <property type="entry name" value="Putative ski oncogene"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000002">
        <property type="entry name" value="SKI-like oncogene a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF3">
        <property type="entry name" value="SKI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="4">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="538"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="684" mass="77069" checksum="7E5508C231184C2A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N2J4</accession>
    <name>A0A8I5N2J4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MAST4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
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    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
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        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2631" mass="285208" checksum="7BE470119BC4884B" modified="2022-05-25" version="1"> </sequence>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N3M8</accession>
    <name>A0A8I5N3M8_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPANG00000046396.1"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="132" mass="15111" checksum="6BF1F2FAA2FB9F82" modified="2022-05-25" version="1">MYDDCPGDLCLGFSPPDETWTSTVPLCSDSMAPYLNVELRTSSGSCFAFSFFFFFFFETESRSVAQAGVQWCDLGSLQPLPPGFKRFSCLRLPSSWDYRCPPPCPANFFFSIFSRDRVSPHWPDWSRTPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N468</accession>
    <name>A0A8I5N468_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nexilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N468"/>
    <dbReference type="Ensembl" id="ENSPANT00000065242.1">
        <property type="protein sequence ID" value="ENSPANP00000053717.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
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    </feature>
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            <begin position="29"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="34221" checksum="1F249A659C2500BF" modified="2022-05-25" version="1">MLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRVRYDEQRRSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEDEKRAFEEARRQMVNEEEENQDPAKIFKGYRPGKLKLSFEEIERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVRQKLTGECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8K1</accession>
    <name>A0A8I5N8K1_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A8I5N8K1"/>
    <dbReference type="Ensembl" id="ENSPANT00000080789.1">
        <property type="protein sequence ID" value="ENSPANP00000056057.1"/>
        <property type="gene ID" value="ENSPANG00000044833.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000163505"/>
    <dbReference type="OMA" id="ETIGTCH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF75">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="130" mass="14594" checksum="60242848E2668DF5" modified="2022-05-25" version="1">MVLISLPRDPPTSASQSARITGISHCSWPQFAFILTIMGETVILKKCRILSIYFIFFFFFFFFFLRRSLALSPRLECSGRISAHCKLHLPGLCHSPASASRVAGTTGARHLARLVFFFFVLFSRDGVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NAB9</accession>
    <name>A0A8I5NAB9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-CpG binding domain protein 3 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MBD3L1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NAB9"/>
    <dbReference type="Ensembl" id="ENSPANT00000072167.1">
        <property type="protein sequence ID" value="ENSPANP00000053627.1"/>
        <property type="gene ID" value="ENSPANG00000042687.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183005"/>
    <dbReference type="OMA" id="HDCGNQS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyl-CpG-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG binding protein 2/3 C-terminal" evidence="1">
        <location>
            <begin position="81"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="195" mass="21708" checksum="CAA3502043EDCA9E" modified="2022-05-25" version="1">MGKSSQRKQRDCVNQCKSKPGLNTSIPLRMSNYTFKSPVTRITPHPGNEVRYHQWEESLEKPQQVCWQKRLQGLQAYSSAGELLSTLDLANTLQKLVPSYTGGSLLGDLAGGLEHSCPMPHLACSSDVVEIIPREGVGISQLLCQQFLVTEEDIRKQEWKVKTVRERLAIALIADGLANEAEKVRGQEGCPEKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBK4</accession>
    <name>A0A8I5NBK4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PHACTR1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021792297.1">
        <property type="nucleotide sequence ID" value="XM_021936605.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792298.1">
        <property type="nucleotide sequence ID" value="XM_021936606.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021792299.1">
        <property type="nucleotide sequence ID" value="XM_021936607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBK4"/>
    <dbReference type="SMR" id="A0A8I5NBK4"/>
    <dbReference type="Ensembl" id="ENSPANT00000072426.1">
        <property type="protein sequence ID" value="ENSPANP00000049884.1"/>
        <property type="gene ID" value="ENSPANG00000024975.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000244"/>
    <dbReference type="CTD" id="221692"/>
    <dbReference type="GeneTree" id="ENSGT00940000155842"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF6">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
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            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
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                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Quiroz J.Q."/>
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                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
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                <person name="Usmani K.U."/>
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                <person name="Woodworth J.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
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            <begin position="232"/>
            <end position="283"/>
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            <begin position="1"/>
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            <begin position="336"/>
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        <location>
            <begin position="599"/>
            <end position="663"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="512"/>
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    </feature>
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        <location>
            <begin position="7"/>
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        <location>
            <begin position="600"/>
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            <begin position="643"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50200"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8I5NDD3_PAPAN</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <source>
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            <fullName evidence="5">Surface protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="HTLV-1-like_HR1-HR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF73">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41619" checksum="0313D9A86F6904F6" modified="2022-05-25" version="1">ATSWSSYPTATLQIRRVYVQQVPAPKSKQVYPPKSVQALQNLTSVVKSHEQKIQKLLSPPNSPNNEDPFSWLTLIHQGLNLTQAAGVRNLSHCFLCAALGKAPLVAVPLPITFNITTDSTSSSQATSLPQVPLYRNPQSQTLPFCYSTPNSSWCDRTQAPSRTQTAPVGGYFWCNQTLSKTLNHASITQSLCVPVSLVPSLTLYSEGELPELASQLSSSNNIQKQAVFLPLIIGVSLASSLVASGLGTGALTHSIQSTQTLSTQVQAAIEALAESLASLQRQITSVAQVAAQNRRALDLLTAEKGGTCLFLGEECCYYVNESGLVDTNVKTLNKIKKELQQFNAPLTPGPPVWLLPVVQQMLPFLIPILILCLMLCLAPILIKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NF38</accession>
    <name>A0A8I5NF38_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Nibrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NBN</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage. Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions. Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MRN complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NF38"/>
    <dbReference type="Ensembl" id="ENSPANT00000076730.1">
        <property type="protein sequence ID" value="ENSPANP00000061165.1"/>
        <property type="gene ID" value="ENSPANG00000011020.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000521"/>
    <dbReference type="OMA" id="KKNFKMF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070533">
        <property type="term" value="C:BRCA1-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042405">
        <property type="term" value="C:nuclear inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140031">
        <property type="term" value="F:phosphorylation-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001832">
        <property type="term" value="P:blastocyst growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904354">
        <property type="term" value="P:negative regulation of telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031860">
        <property type="term" value="P:telomeric 3' overhang formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17741">
        <property type="entry name" value="BRCT_nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000017">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000024">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10980:FF:000001">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013908">
        <property type="entry name" value="Nibrin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016592">
        <property type="entry name" value="Nibrin_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08599">
        <property type="entry name" value="Nbs1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011869">
        <property type="entry name" value="Nibrin_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
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    <keyword evidence="7 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 12" id="KW-0469">Meiosis</keyword>
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    <keyword evidence="6 12" id="KW-0779">Telomere</keyword>
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        <location>
            <begin position="24"/>
            <end position="83"/>
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            <begin position="326"/>
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        <location>
            <begin position="425"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="505"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR011869"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="766" mass="86193" checksum="54E05DEDBF54AD28" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFJ4</accession>
    <name>A0A8I5NFJ4_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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        <property type="entry name" value="RT_dom"/>
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        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Exo_endo_phos"/>
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        <location>
            <begin position="498"/>
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        <location>
            <begin position="307"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="12">Dickkopf WNT signaling pathway inhibitor 2</fullName>
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        <name evidence="12" type="primary">DKK2</name>
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    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dickkopf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899113.1">
        <property type="nucleotide sequence ID" value="XM_003899064.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHA1"/>
    <dbReference type="Ensembl" id="ENSPANT00000083510.1">
        <property type="protein sequence ID" value="ENSPANP00000058601.1"/>
        <property type="gene ID" value="ENSPANG00000040092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101014746"/>
    <dbReference type="KEGG" id="panu:101014746"/>
    <dbReference type="CTD" id="27123"/>
    <dbReference type="GeneTree" id="ENSGT00940000162188"/>
    <dbReference type="OrthoDB" id="4321958at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23015">
        <property type="entry name" value="Dkk2_Cys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23273">
        <property type="entry name" value="Dkk2_Cys2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.80.10:FF:000001">
        <property type="entry name" value="Dickkopf WNT-signaling pathway inhibitor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048500">
        <property type="entry name" value="DIKK1/2/4_C-subdom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048499">
        <property type="entry name" value="DIKK1/2/4_C-subdom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047303">
        <property type="entry name" value="Dkk2_Cys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047302">
        <property type="entry name" value="Dkk2_Cys2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF12">
        <property type="entry name" value="DICKKOPF-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21481">
        <property type="entry name" value="DIKK1-2-4_C-subdom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21479">
        <property type="entry name" value="DIKK1-2-4_C-subdom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196688" evidence="8">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf N-terminal cysteine-rich" evidence="9">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf-related protein 1/2/4 C-terminal subdomain 1" evidence="11">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf-related protein 1/2/4 C-terminal subdomain 2" evidence="10">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="259" mass="28500" checksum="907479492F24A418" modified="2022-05-25" version="1">MAALMRCKDSSRCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPAQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPGTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHK9</accession>
    <name>A0A8I5NHK9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NHK9"/>
    <dbReference type="Ensembl" id="ENSPANT00000076520.1">
        <property type="protein sequence ID" value="ENSPANP00000054526.1"/>
        <property type="gene ID" value="ENSPANG00000043447.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166673"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="170" mass="19736" checksum="055F1A63EC08E341" modified="2022-05-25" version="1">MGKEFMSKTPKAMATKAKIDKWDLIKLKSFCTAKETTIRVNRQPTEWEKIFAIYSSDKGLISRTYKELKQIYKKKTNNPIKKWAKDMNRQFSFFFFLRRSLALCPRLECSGAISAHCKLRPPGFTPFSCLSLPSSWDYRRPPPRPANFLVFLVETGFHRVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NI69</accession>
    <name>A0A8I5NI69_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NI69"/>
    <dbReference type="Ensembl" id="ENSPANT00000082468.1">
        <property type="protein sequence ID" value="ENSPANP00000049019.1"/>
        <property type="gene ID" value="ENSPANG00000044645.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="20550" checksum="5AB1D04E07C2C7BF" modified="2022-05-25" version="1">MQDDFPTSLCTVTYGAGVVWGCDFVQELYEGENSFIQIILRFFLSLPLSLSLSFSPSLPLSLFFFFFFLRGSLALLPRLERSSTMSAHCKLHLPGSCHSPASASRVAETTGVCHHTQLSFFFFFFFFETESHSVAQAGVQWPDLGSLQAPPPGFTPFSCLSLPSSWDYRRPPPRPANFFFCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLB1</accession>
    <name>A0A8I5NLB1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="4">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MBTPS2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="4"/>
    <dbReference type="RefSeq" id="XP_009195594.1">
        <property type="nucleotide sequence ID" value="XM_009197330.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLB1"/>
    <dbReference type="Ensembl" id="ENSPANT00000074185.1">
        <property type="protein sequence ID" value="ENSPANP00000050747.1"/>
        <property type="gene ID" value="ENSPANG00000024280.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998047"/>
    <dbReference type="CTD" id="51360"/>
    <dbReference type="GeneTree" id="ENSGT00510000048066"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06775">
        <property type="entry name" value="cpPDZ_MBTPS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06162">
        <property type="entry name" value="S2P-M50_PDZ_SREBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="13">
        <location>
            <begin position="160"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="520" mass="57529" checksum="3B024CCD9F0A785A" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQD7</accession>
    <name>A0A8I5NQD7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NQD7"/>
    <dbReference type="Ensembl" id="ENSPANT00000063248.1">
        <property type="protein sequence ID" value="ENSPANP00000056259.1"/>
        <property type="gene ID" value="ENSPANG00000049288.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="OMA" id="EGAIYES"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF135">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="210" mass="22422" checksum="E48EFF67A61DA53D" modified="2022-05-25" version="1">MPLGSSVISLEGKEMFLTGLALSPRLECSGAISAHCNLCLPGSRDLAISASEVAGTTDVCHHAKLIFVETRLRHVCQAGLQLLNSTNSPTAASQGDYRQLLQDYTKKAKRIHRPPEGSRLLLQDPGDSPNTTQQEGAIYESESGSSPDTKSAGVLTLDFPASRTARSRCVAQAGVQWLFTGVIMACCISNSWPQVTLLPQSPEELGLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQE2</accession>
    <name>A0A8I5NQE2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NQE2"/>
    <dbReference type="Ensembl" id="ENSPANT00000071798.1">
        <property type="protein sequence ID" value="ENSPANP00000052922.1"/>
        <property type="gene ID" value="ENSPANG00000037059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="168" mass="18789" checksum="CB90FE05747A4388" modified="2022-05-25" version="1">FSVLPFTLLTRRSDSRHLCLTLFCLFVLRQSHSVAQAGVQWHDLGLLQSPPPGFKQSFHLSFPNSWDYKHVPPCPDNFFVYLVETGFHHVGQAGLELLTSSDPPVSASQSAGITDMSHHTPSGLGLLIIAIVCWFSASLIFTFIFIISFLMLSLSLFCWEFFSSYSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NT81</accession>
    <name>A0A8I5NT81_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LINE-1 retrotransposable element ORF1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LINE retrotransposable element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LINE1 retrotransposable element 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the transposase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NT81"/>
    <dbReference type="Ensembl" id="ENSPANT00000060798.1">
        <property type="protein sequence ID" value="ENSPANP00000060661.1"/>
        <property type="gene ID" value="ENSPANG00000038641.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286955"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.250.20:FF:000005">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1820:FF:000002">
        <property type="entry name" value="LINE-1 retrotransposable element ORF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035300">
        <property type="entry name" value="L1_dsRBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035301">
        <property type="entry name" value="L1_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17490">
        <property type="entry name" value="Tnp_22_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17489">
        <property type="entry name" value="Tnp_22_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="L1 transposable element trimerization" evidence="15">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element RRM" evidence="14">
        <location>
            <begin position="155"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="L1 transposable element dsRBD-like" evidence="16">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="39683" checksum="D9BB06F0DA06D775" modified="2022-05-25" version="1">MGKKHGRKAGNSKNKSASPPAKEHSSSPATDQTLTENDFDEMREEGFSPSNFSELKEELRTQRKETKNLEKKVEELMARVINAEKVINKMKEMKTMTREIRDKCTSFSNRLDQLEERVSAIEDQMNKMKREEKPKEKRRKRNEQSLQEVWDYVKRPNLRLIGVPERKGENGTKLENTLQDIIQENFPNLVGQANIQIQEIQRTPQRYSPRRATPRHIIARFTKVEMKEKILRAAREKGRVTHKGKPIRLTARLSAETLQARREWGPILNIFKEKNFKPRISYPAKLSFISEGEIKSFTDKQMLRDFVITRPALQETLKEALNMERNNRYQPLQKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXD7</accession>
    <name>A0A8I5NXD7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S100/CaBP-9k-type calcium binding subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NXD7"/>
    <dbReference type="Ensembl" id="ENSPANT00000061435.1">
        <property type="protein sequence ID" value="ENSPANP00000055326.1"/>
        <property type="gene ID" value="ENSPANG00000041214.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003322"/>
    <dbReference type="OMA" id="IFRNACD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S100/CaBP-9k-type calcium binding subdomain" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="78" mass="8611" checksum="CFF42F3FAC139C5C" modified="2022-05-25" version="1">MPKSISIPKQLASVKALRKCSDLEKAIATTALIFRNSSDSDGKLEKATAKDLLQTQFGNFTEVRELTCIKKQEPHPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NZ19</accession>
    <name>A0A8I5NZ19_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-repair protein Xrcc1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NZ19"/>
    <dbReference type="Ensembl" id="ENSPANT00000076128.1">
        <property type="protein sequence ID" value="ENSPANP00000056382.1"/>
        <property type="gene ID" value="ENSPANG00000037085.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004140"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000025">
        <property type="entry name" value="DNA repair protein XRCC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF4">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-repair protein Xrcc1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="433" mass="47840" checksum="A42E28F8B5881035" modified="2022-05-25" version="1">MAPVKISHVVSFSSQDPRYPVENLLNPDNPRRPWLSCPQDKSGQLKVELQLERAVPIGYIDVGNCGCAFLQIDVGRSSWPLDRPFVTLLPATMLMSLTDSKQGKNRSGVRMFKDVDFLAPASGELWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLDDSVLGPSALVSSVLNKGSDAQESGPSPWLANPSIRRTFFPHPHTDTKEISELRNILTQMQPGTLGRSAHMVLSAARRVPPVSVASPKNNHAESGSSPPDRAEPRAEEQNSENDVGRMKRRKVQHQRPVSNSNSRPNRRETARARQKKQHRPQAQSSGDQDSGLCPICADRPTPTTNSMGALHPTNMSLRPNCEPSMVPGTGVMKKSPVPAEQLGRLLKIPVLKFLLHSASCLWFLIFLLGESLVVETQLSTFRGRSQSVWETSLHMIWVTGSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P1M2</accession>
    <name>A0A8I5P1M2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P1M2"/>
    <dbReference type="Ensembl" id="ENSPANT00000066376.1">
        <property type="protein sequence ID" value="ENSPANP00000058471.1"/>
        <property type="gene ID" value="ENSPANG00000040961.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000058471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="53" mass="6080" checksum="3E9373EF3B7F4CB1" modified="2022-05-25" version="1">MEFRSVTQAGVQWRDLGSLQAPPPGFTPFSCLSLRSSWDYMRPPPRPASFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2S7</accession>
    <name>A0A8I5P2S7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">POLD1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5P2S7"/>
    <dbReference type="Ensembl" id="ENSPANT00000063306.1">
        <property type="protein sequence ID" value="ENSPANP00000059467.1"/>
        <property type="gene ID" value="ENSPANG00000006810.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00560000077365"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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        <property type="entry name" value="Palm domain of DNA polymerase"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
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        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
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    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
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    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
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            <begin position="143"/>
            <end position="220"/>
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            <begin position="243"/>
            <end position="496"/>
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            <begin position="560"/>
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            <begin position="1"/>
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            <begin position="1070"/>
            <end position="1097"/>
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            <begin position="1157"/>
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            <begin position="23"/>
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            <begin position="1162"/>
            <end position="1171"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03104"/>
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            <dbReference type="Pfam" id="PF24055"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1179" mass="128928" checksum="CB47F46036DCE4F8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R2T2</accession>
    <name>A0A8I5R2T2_PAPAN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060796.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="118" mass="13687" checksum="ADF2A81A7117F2FA" modified="2022-05-25" version="1">PVEIQGSELDPVFFSLYSHYVFYYFILLIFIYLFIYLFIYLFIYFETESRSVAQAGVQWPDLSSLQAPPPAFTPFSCLSLPSSWDYRRPPPRPASFLYFLLETGFHGVSQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G4XXN9</accession>
    <name>G4XXN9_PAPAN</name>
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        <recommendedName>
            <fullName evidence="4">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CYCS</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E26269" last="E26269">
            <title>Silencing, positive selection and parallel evolution: busy history of primate cytochromes C.</title>
            <authorList>
                <person name="Pierron D."/>
                <person name="Opazo J.C."/>
                <person name="Heiske M."/>
                <person name="Papper Z."/>
                <person name="Uddin M."/>
                <person name="Chand G."/>
                <person name="Wildman D.E."/>
                <person name="Romero R."/>
                <person name="Goodman M."/>
                <person name="Grossman L.I."/>
            </authorList>
            <dbReference type="PubMed" id="22028846"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0026269"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 17">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="17">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="JF919244">
        <property type="protein sequence ID" value="AEP27209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4XXN9"/>
    <dbReference type="SMR" id="G4XXN9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008653"/>
    <dbReference type="Ensembl" id="ENSPANT00000036801.2">
        <property type="protein sequence ID" value="ENSPANP00000024946.1"/>
        <property type="gene ID" value="ENSPANG00000033986.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000065541.1">
        <property type="protein sequence ID" value="ENSPANP00000053865.1"/>
        <property type="gene ID" value="ENSPANG00000050044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100997529"/>
    <dbReference type="KEGG" id="panu:100997529"/>
    <dbReference type="KEGG" id="panu:101008579"/>
    <dbReference type="eggNOG" id="KOG3453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009405"/>
    <dbReference type="HOGENOM" id="CLU_060944_3_0_1"/>
    <dbReference type="OMA" id="ARCKACH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002060">
        <property type="expression patterns" value="Expressed in heart and 69 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000008">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEP27209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="105" mass="11737" checksum="B590589E01024BE1" modified="2011-12-14" version="1">MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGITWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q863G9</accession>
    <name>COX8A_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c oxidase subunit 8A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome c oxidase polypeptide VIII-liver/heart</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytochrome c oxidase subunit 8-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">COX8A</name>
        <name type="synonym">COX8</name>
        <name type="synonym">COX8L</name>
    </gene>
    <organism>
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="5873" last="5878">
            <title>Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates.</title>
            <authorList>
                <person name="Goldberg A."/>
                <person name="Wildman D.E."/>
                <person name="Schmidt T.R."/>
                <person name="Huttemann M."/>
                <person name="Goodman M."/>
                <person name="Weiss M.L."/>
                <person name="Grossman L.I."/>
            </authorList>
            <dbReference type="PubMed" id="12716970"/>
            <dbReference type="DOI" id="10.1073/pnas.0931463100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIII family.</text>
    </comment>
    <dbReference type="EMBL" id="AY254817">
        <property type="protein sequence ID" value="AAP32248.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001106111.1">
        <property type="nucleotide sequence ID" value="NM_001112641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q863G9"/>
    <dbReference type="SMR" id="Q863G9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000046331"/>
    <dbReference type="Ensembl" id="ENSPANT00000064263.1">
        <property type="protein sequence ID" value="ENSPANP00000048066.1"/>
        <property type="gene ID" value="ENSPANG00000039572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100126727"/>
    <dbReference type="KEGG" id="panu:100126727"/>
    <dbReference type="CTD" id="1351"/>
    <dbReference type="eggNOG" id="ENOG502SA62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006255"/>
    <dbReference type="HOGENOM" id="CLU_203368_0_0_1"/>
    <dbReference type="OMA" id="AQVHSMP"/>
    <dbReference type="OrthoDB" id="8931496at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034851">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.81.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 8B, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.81.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003205">
        <property type="entry name" value="Cyt_c_oxidase_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036548">
        <property type="entry name" value="Cyt_c_oxidase_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16717">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16717:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 8A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02285">
        <property type="entry name" value="COX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81431">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000006193" description="Cytochrome c oxidase subunit 8A, mitochondrial">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="61"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="SIFI-degron" evidence="2">
        <location>
            <begin position="2"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P10176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="69" mass="7631" checksum="E90BF11533D280F7" modified="2003-06-01" version="1" precursor="true">MSVLTSLLLRGLTGSARRLPVPRAKVHSMPPEEELGTLEKAIALTSCFVSLFLPAGWILSHLEDYKRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKM5</accession>
    <name>A0A096MKM5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin-specific chaperone C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tubulin-folding cofactor C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TBCC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin-folding protein; involved in the final step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897653.1">
        <property type="nucleotide sequence ID" value="XM_003897604.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKM5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000041"/>
    <dbReference type="Ensembl" id="ENSPANT00000000823.3">
        <property type="protein sequence ID" value="ENSPANP00000000041.3"/>
        <property type="gene ID" value="ENSPANG00000025697.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006279"/>
    <dbReference type="KEGG" id="panu:101006279"/>
    <dbReference type="CTD" id="6903"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162058"/>
    <dbReference type="HOGENOM" id="CLU_032612_2_1_1"/>
    <dbReference type="OMA" id="YFQHEIT"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025697">
        <property type="expression patterns" value="Expressed in amygdala and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1250:FF:000001">
        <property type="entry name" value="Tubulin-specific chaperone C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000007">
        <property type="entry name" value="tubulin-specific chaperone C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="12">
        <location>
            <begin position="171"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000041.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="346" mass="39453" checksum="74C6DE7832A1CBD4" modified="2022-05-25" version="3">MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEAEKENSHFFAATFARERAAVEELLERAESVERLEEAASRLQGLQKLLNDSVFFLAAYDLRQGQQALARLQAALDERRRELQPKKRFAFKTRRKDAASSTKVDAAPGIPPAVESLRDSPLPKKAEGDLGSSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVKLYGNPNTLRLTRTHNCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKR8</accession>
    <name>A0A096MKR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid receptor RNA activator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Steroid receptor RNA activator protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SRA1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SRA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900259.1">
        <property type="nucleotide sequence ID" value="XM_003900210.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKR8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000094"/>
    <dbReference type="Ensembl" id="ENSPANT00000024152.3">
        <property type="protein sequence ID" value="ENSPANP00000000094.1"/>
        <property type="gene ID" value="ENSPANG00000008615.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008148"/>
    <dbReference type="KEGG" id="panu:101008148"/>
    <dbReference type="CTD" id="10011"/>
    <dbReference type="eggNOG" id="ENOG502RZ38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001803"/>
    <dbReference type="HOGENOM" id="CLU_081395_0_0_1"/>
    <dbReference type="OMA" id="VPGIQHD"/>
    <dbReference type="OrthoDB" id="5982138at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008615">
        <property type="expression patterns" value="Expressed in pancreas and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002153">
        <property type="term" value="F:steroid receptor RNA activator RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045662">
        <property type="term" value="P:negative regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000006">
        <property type="entry name" value="steroid receptor RNA activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040243">
        <property type="entry name" value="Steroid_recept_RNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834:SF2">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SRA1/Sec31" evidence="18">
        <location>
            <begin position="74"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="235" mass="25723" checksum="B5897AF79D1E1AB4" modified="2014-11-26" version="1">MTRCPAGQAEVEMAELYVKPGNKERGWNDPPQFSYGLQTQASGHRRSLLTKRVAAPQDGSPRVPTSETSPGPPPMGPPPPSSKAPRPPPVGSGPASGMEPTSFPVESEALMEDVLRPLEQALEDCRGHTRKQVCDDISRRLALLQEQWAGGKLSIPVKKRMAVLVQELSSHRWDAADDIHRSLMVDYVTEVSQWMVGVKRLIAEKRSLFSEEAANEEKSAATAENHTIPGFQQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMB3</accession>
    <name>A0A096MMB3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyltransferase PGAP2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Post-GPI attachment to proteins factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PGAP2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the second step of the fatty acid remodeling, by reacylating a lyso-GPI intermediate at sn-2 of inositol phosphate by a saturated chain. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with PGAP2IP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009185067.1">
        <property type="nucleotide sequence ID" value="XM_009186803.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021781904.1">
        <property type="nucleotide sequence ID" value="XM_021926212.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MMB3"/>
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        <property type="protein sequence ID" value="ENSPANP00000000736.3"/>
        <property type="gene ID" value="ENSPANG00000024371.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 12"/>
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    <dbReference type="Bgee" id="ENSPANG00000024371">
        <property type="expression patterns" value="Expressed in esophagus and 64 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A096MMB3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
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    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
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    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
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    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
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    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="166"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="186"/>
            <end position="204"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
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    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011213"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093421"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000736.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="254" mass="29310" checksum="082AC24589A7B57A" modified="2022-05-25" version="3">MYQVPLPLDRDGTLVRLRFTVVALVTVCCPLVAFLFCILWSLLFHFKETTATHCGVPNYLPSVSSAIGGEVPQRYVWRFCIGLHSAPRFLVAFAYWNHYLSCASPCSCYRPLCRLNFGLNVVENLALLVLTYVSSSEDFTIHENAFIVFIASSLGHMLLTCILWRLTKKHTVSQEDRKSYSWKQRLFVINFVSFFSALAVYFRHNMYCEAGVYTIFAILEYTVVLTNMAFHMTAWWDFGNKELLITSQPEEKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNT1</accession>
    <name>A0A096MNT1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Single-pass membrane protein with coiled-coil domains 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SMCO3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_003906051.5"/>
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        <property type="protein sequence ID" value="ENSPANP00000001344.1"/>
        <property type="gene ID" value="ENSPANG00000006587.3"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RYUI">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000013440"/>
    <dbReference type="HOGENOM" id="CLU_1229530_0_0_1"/>
    <dbReference type="OMA" id="MSTNFHA"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006587">
        <property type="expression patterns" value="Expressed in metanephros cortex and 52 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027895">
        <property type="entry name" value="DUF4533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040004">
        <property type="entry name" value="SMCO3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35972">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35972:SF1">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15047">
        <property type="entry name" value="DUF4533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001344.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="225" mass="24886" checksum="1ECE953C1B595502" modified="2014-11-26" version="1">MAQSDFLYPENPKRRQEVNRLHQQLLDCLSDSFDVTNKLTEVLNTHLGCRLASIEMKRDGTIKENCDIIIQAIMKIQKELQKVDEALKDKLEPTLYRKLQDIKEKETEKIAIVQQVISVILGEATSAASAVAVKLVGSNITTGIINKLVTVLAQIGASLLGSIGVAVLGLGIDMIVRAILGAVEKTQLQAAIKSYEKHLVEFKSASEKYNHAITEVINLVKHQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MP08</accession>
    <name>A0A096MP08_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein crumbs homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CRB1</name>
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    <organism evidence="26 27">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of a complex composed of PALS1, CRB1 and EPB41L5. Within the complex, interacts (via intracellular domain) with PALS1 and EPB41L5 (via FERM domain). Forms a complex with MPP4 and PALS1. Interacts with MPDZ/MUPP1 and MPP4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the Crumbs protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000001441"/>
    <dbReference type="Ensembl" id="ENSPANT00000013892.3">
        <property type="protein sequence ID" value="ENSPANP00000001441.3"/>
        <property type="gene ID" value="ENSPANG00000006812.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155152"/>
    <dbReference type="OMA" id="RDMFIML"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006812">
        <property type="expression patterns" value="Expressed in iris and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MP08">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097386">
        <property type="term" value="C:glial cell projection"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035003">
        <property type="term" value="C:subapical complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062139">
        <property type="term" value="P:camera-type eye photoreceptor cell development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0061159">
        <property type="term" value="P:establishment of bipolar cell polarity involved in cell morphogenesis"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045494">
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    </dbReference>
    <dbReference type="GO" id="GO:0035845">
        <property type="term" value="P:photoreceptor cell outer segment organization"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0060060">
        <property type="term" value="P:post-embryonic retina morphogenesis in camera-type eye"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000348">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000484">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000517">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000081">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000208">
        <property type="entry name" value="Crumbs 2, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000039">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000274">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000400">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000413">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000468">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000055">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000090">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000252">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
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    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
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    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
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    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
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    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="17"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 21" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035151713" description="Protein crumbs homolog 1" evidence="23">
        <location>
            <begin position="28"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1389"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="110"/>
            <end position="146"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="339"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="24">
        <location>
            <begin position="485"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="24">
        <location>
            <begin position="714"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="933"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="24">
        <location>
            <begin position="995"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1184"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1222"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1259"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1305"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1342"/>
            <end position="1378"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="96"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="98"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="136"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="212"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="250"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="327"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="385"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
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            <end position="480"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="698"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="958"/>
            <end position="967"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1210"/>
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    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1226"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1247"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1285"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1330"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001441.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1451" mass="158655" checksum="8C39B32B081D30F2" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MP75</accession>
    <name>A0A096MP75_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring finger protein 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RNF44</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MP75"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001514"/>
    <dbReference type="Ensembl" id="ENSPANT00000008358.3">
        <property type="protein sequence ID" value="ENSPANP00000001514.2"/>
        <property type="gene ID" value="ENSPANG00000009299.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158553"/>
    <dbReference type="HOGENOM" id="CLU_024578_0_0_1"/>
    <dbReference type="OMA" id="MSSEHFV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009299">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000024">
        <property type="entry name" value="RING finger protein 44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF2">
        <property type="entry name" value="RING FINGER PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="380"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001514.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="449" mass="49511" checksum="6A6C40B301F70672" modified="2022-05-25" version="2">MRPWALAVTRWPPSAPVGQRRFSAGPGSTPGQFWGSPGLEGPLASPPARDERLPSQQPPSRPPHLPVEERRASAPAGGGPRMLHPATQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPTGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQACTMQQLPVPYQAYPHLISSDHYILHPPPPAPPPQPTHMAPLGQFVSLQAQHPRMPLQRLDNDVDLRGDQHSLGSFTYSTSAPGPALSPSVPLHYLPHDPLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFETRQLLRVLPCNHEFHTKCVDKWLKVTLPRPAPGHSSCSDRGMGRPGLFPSLSLSSSQKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQR3</accession>
    <name>A0A096MQR3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 63A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM63A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893091.2">
        <property type="nucleotide sequence ID" value="XM_003893042.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017804607.2">
        <property type="nucleotide sequence ID" value="XM_017949118.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQR3"/>
    <dbReference type="Ensembl" id="ENSPANT00000021719.3">
        <property type="protein sequence ID" value="ENSPANP00000002097.3"/>
        <property type="gene ID" value="ENSPANG00000009888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012422"/>
    <dbReference type="KEGG" id="panu:101012422"/>
    <dbReference type="CTD" id="9725"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159576"/>
    <dbReference type="HOGENOM" id="CLU_015647_2_0_1"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009888">
        <property type="expression patterns" value="Expressed in mesenteric fat pad and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQR3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990760">
        <property type="term" value="F:osmolarity-sensing monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160069">
        <property type="term" value="P:surfactant secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF24">
        <property type="entry name" value="CSC1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="53"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="228"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="422"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002097.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="805" mass="91728" checksum="70E9E938C4B94942" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRW1</accession>
    <name>A0A096MRW1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PFDN2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893000.2">
        <property type="nucleotide sequence ID" value="XM_003892951.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRW1"/>
    <dbReference type="SMR" id="A0A096MRW1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002520"/>
    <dbReference type="Ensembl" id="ENSPANT00000022321.3">
        <property type="protein sequence ID" value="ENSPANP00000002520.2"/>
        <property type="gene ID" value="ENSPANG00000014788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000313"/>
    <dbReference type="KEGG" id="panu:101000313"/>
    <dbReference type="CTD" id="5202"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009272"/>
    <dbReference type="HOGENOM" id="CLU_113004_2_1_1"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014788">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002520.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="154" mass="16648" checksum="2FC68A7425412198" modified="2018-02-28" version="2">MAENSGRAGKSSGSGAGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQIQKIIETLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUN4</accession>
    <name>A0A096MUN4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain containing 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TXNDC15</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MUN4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003550"/>
    <dbReference type="Ensembl" id="ENSPANT00000009009.3">
        <property type="protein sequence ID" value="ENSPANP00000003550.1"/>
        <property type="gene ID" value="ENSPANG00000018501.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002845"/>
    <dbReference type="HOGENOM" id="CLU_050221_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018501">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02999">
        <property type="entry name" value="PDI_a_ERp44_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042418">
        <property type="entry name" value="TXNDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001921846" evidence="3">
        <location>
            <begin position="33"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="153"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="360" mass="39956" checksum="2BDC1B70EA83D9C0" modified="2014-11-26" version="1">VVLAAGRRPPRVMRLLSWWQVLLWVLGRPVRGVEVAEESGRLWAEEQPAHPLQVGAVYLGEEELLHDPMGQDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGGTCGAGGEEDSRCNLRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKSVDWLLVFSLFFLISFIMYATIRTESIRWLIPGQEQEHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUP8</accession>
    <name>A0A096MUP8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein S100-A13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">S100 calcium-binding protein A13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">S100A13</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1. Interacts with IL1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009180118.1">
        <property type="nucleotide sequence ID" value="XM_009181854.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009180123.1">
        <property type="nucleotide sequence ID" value="XM_009181859.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MUP8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003564"/>
    <dbReference type="Ensembl" id="ENSPANT00000024305.3">
        <property type="protein sequence ID" value="ENSPANP00000003564.1"/>
        <property type="gene ID" value="ENSPANG00000003887.3"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05022">
        <property type="entry name" value="S-100A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000260">
        <property type="entry name" value="Protein S100-A13"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF57">
        <property type="entry name" value="PROTEIN S100-A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="S100/CaBP-9k-type calcium binding subdomain" evidence="18">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="ARBA" id="ARBA00007323"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069237"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076815"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01394"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003564.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="98" mass="11485" checksum="0F8BF7FDACD49E9E" modified="2014-11-26" version="1">MAAEPLTELEESIETVVTTFFTFARQEGRKDSLSINEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUQ0</accession>
    <name>A0A096MUQ0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Growth factor independent 1 transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GFI1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003892250.1">
        <property type="nucleotide sequence ID" value="XM_003892201.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003892251.1">
        <property type="nucleotide sequence ID" value="XM_003892202.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031506669.1">
        <property type="nucleotide sequence ID" value="XM_031650809.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A096MUQ0"/>
    <dbReference type="SMR" id="A0A096MUQ0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003566"/>
    <dbReference type="Ensembl" id="ENSPANT00000009266.3">
        <property type="protein sequence ID" value="ENSPANP00000003566.1"/>
        <property type="gene ID" value="ENSPANG00000016433.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007365"/>
    <dbReference type="KEGG" id="panu:101007365"/>
    <dbReference type="CTD" id="2672"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156166"/>
    <dbReference type="HOGENOM" id="CLU_002678_94_9_1"/>
    <dbReference type="OMA" id="CDRVSEF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016433">
        <property type="expression patterns" value="Expressed in thymus and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140767">
        <property type="term" value="F:enzyme-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010957">
        <property type="term" value="P:negative regulation of vitamin D biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070105">
        <property type="term" value="P:positive regulation of interleukin-6-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034121">
        <property type="term" value="P:regulation of toll-like receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000489">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000827">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF419">
        <property type="entry name" value="FI21258P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="422" mass="45277" checksum="B749EBCCB45E3A03" modified="2014-11-26" version="1">MPRSFLVKSKKAHSYHQPRSPGSDYSLRLENVPAPSRADSTSNAGGAKAESRDRLSPESQLTEAPDRASASPDSCEGSVCERSSEFEDFWRPPSPSASPASEKSMCPSLDEAQPFPLPFKPYSWSGLAGSDLRHLVQSYRPCGALERGAGLGLFCEPAPEPGHPAALYGPKRAAGGAGAGAPGSCSAGAGATAGPGLGLYGDFGSAAAGLYERPTAAAGLLYPERGHGLHADKGAGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVT1</accession>
    <name>A0A096MVT1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 1 regulatory subunit 3A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein phosphatase 1 glycogen-associated regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein phosphatase type-1 glycogen targeting subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PPP1R3A</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003896549.1">
        <property type="nucleotide sequence ID" value="XM_003896500.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MVT1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003972"/>
    <dbReference type="Ensembl" id="ENSPANT00000018306.3">
        <property type="protein sequence ID" value="ENSPANP00000003972.1"/>
        <property type="gene ID" value="ENSPANG00000017583.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009962"/>
    <dbReference type="KEGG" id="panu:101009962"/>
    <dbReference type="CTD" id="5506"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157682"/>
    <dbReference type="HOGENOM" id="CLU_009399_0_0_1"/>
    <dbReference type="OMA" id="DCWELPS"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017583">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22255">
        <property type="entry name" value="PBD_PPP1R3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2440:FF:000004">
        <property type="entry name" value="protein phosphatase 1 regulatory subunit 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1094"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="15">
        <location>
            <begin position="140"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127638" checksum="BEAF26F03F763DB8" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX90</accession>
    <name>A0A096MX90_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Alpha-2B adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Alpha-2B adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ADRA2B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031511346.1">
        <property type="nucleotide sequence ID" value="XM_031655486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MX90"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004501"/>
    <dbReference type="Ensembl" id="ENSPANT00000013030.3">
        <property type="protein sequence ID" value="ENSPANP00000004501.3"/>
        <property type="gene ID" value="ENSPANG00000025446.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025681"/>
    <dbReference type="KEGG" id="panu:101025681"/>
    <dbReference type="CTD" id="151"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161915"/>
    <dbReference type="HOGENOM" id="CLU_009579_11_1_1"/>
    <dbReference type="OMA" id="ANPWKRK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025446">
        <property type="expression patterns" value="Expressed in heart and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004938">
        <property type="term" value="F:alpha2-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051379">
        <property type="term" value="F:epinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010700">
        <property type="term" value="P:negative regulation of norepinephrine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006940">
        <property type="term" value="P:regulation of smooth muscle contraction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15321">
        <property type="entry name" value="7tmA_alpha2B_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-2B adrenergic receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-2B adrenergic receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000207">
        <property type="entry name" value="ADRA2B_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF130">
        <property type="entry name" value="ALPHA-2B ADRENERGIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00559">
        <property type="entry name" value="ADRENRGCA2BR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="68"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="108"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="150"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="195"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="367"/>
            <end position="388"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
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        <location>
            <begin position="29"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="242"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019305"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023139"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00031735"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="RuleBase" id="RU368059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSPANP00000004501.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="447" mass="49589" checksum="E0E1A12C00C5EB07" modified="2022-05-25" version="3">MDHQDPYSVQATAAIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPNRGGALASAKLPALASLASAREVNGHSKSTGEKEEGETSEDTVTRALPPSWAALPDSGQGQKEGVCGASPEDEAEEEKEEEEEECEPQAGPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZ78</accession>
    <name>A0A096MZ78_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WASH complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">WASH complex subunit strumpellin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WASHC5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003903200.1">
        <property type="nucleotide sequence ID" value="XM_003903151.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017817781.1">
        <property type="nucleotide sequence ID" value="XM_017962292.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021798583.1">
        <property type="nucleotide sequence ID" value="XM_021942891.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZ78"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005273"/>
    <dbReference type="Ensembl" id="ENSPANT00000021448.3">
        <property type="protein sequence ID" value="ENSPANP00000005273.1"/>
        <property type="gene ID" value="ENSPANG00000008560.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025182"/>
    <dbReference type="KEGG" id="panu:101025182"/>
    <dbReference type="CTD" id="9897"/>
    <dbReference type="eggNOG" id="KOG3666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011137"/>
    <dbReference type="HOGENOM" id="CLU_004021_1_0_1"/>
    <dbReference type="OMA" id="FFPDNWV"/>
    <dbReference type="OrthoDB" id="565118at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008560">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MZ78">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090306">
        <property type="term" value="P:meiotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097494">
        <property type="term" value="P:regulation of vesicle size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1159" mass="134423" checksum="4FCE3805186BAB7A" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0I6</accession>
    <name>A0A096N0I6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRIP1 associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GRIPAP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031516764.1">
        <property type="nucleotide sequence ID" value="XM_031660904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0I6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005772"/>
    <dbReference type="Ensembl" id="ENSPANT00000007814.3">
        <property type="protein sequence ID" value="ENSPANP00000005772.3"/>
        <property type="gene ID" value="ENSPANG00000013631.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013335"/>
    <dbReference type="CTD" id="56850"/>
    <dbReference type="eggNOG" id="ENOG502QTUD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00720000108868"/>
    <dbReference type="HOGENOM" id="CLU_019728_1_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013631">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N0I6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098998">
        <property type="term" value="C:extrinsic component of postsynaptic early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905244">
        <property type="term" value="P:regulation of modification of synaptic structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099152">
        <property type="term" value="P:regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099158">
        <property type="term" value="P:regulation of recycling endosome localization within postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026204">
        <property type="entry name" value="GRIPAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978">
        <property type="entry name" value="GRIP-1 ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978:SF1">
        <property type="entry name" value="GRIP1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005772.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="841" mass="96042" checksum="DA53CE97AE91D5A3" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0N6</accession>
    <name>A0A096N0N6_PAPAN</name>
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        <submittedName>
            <fullName evidence="16">Glycerol-3-phosphate acyltransferase 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="16" type="primary">GPAT4</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
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        <property type="nucleotide sequence ID" value="XM_009212959.4"/>
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        <property type="nucleotide sequence ID" value="XM_031669502.1"/>
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        <property type="protein sequence ID" value="ENSPANP00000005824.1"/>
        <property type="gene ID" value="ENSPANG00000020590.3"/>
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    <dbReference type="HOGENOM" id="CLU_031080_0_1_1"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:acyl-CoA metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:diacylglycerol metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF37">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
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    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="156"/>
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            <begin position="180"/>
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    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
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            <begin position="242"/>
            <end position="353"/>
        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00563"/>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSPANP00000005824.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="456" mass="52086" checksum="D227B44AC44F257B" modified="2014-11-26" version="1">MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKTLLKIFAWATLRMERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRIALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHEDRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0R3</accession>
    <name>A0A096N0R3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RTN4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
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                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
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                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Could coordinate an aspect of bone turnover.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPP2 family.</text>
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        <property type="gene ID" value="ENSPANG00000019534.3"/>
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        <property type="expression patterns" value="Expressed in liver and 7 other cell types or tissues"/>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Secreted phosphoprotein 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cystatin_sf"/>
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    <dbReference type="InterPro" id="IPR010892">
        <property type="entry name" value="Spp-24"/>
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    <dbReference type="PANTHER" id="PTHR15444">
        <property type="entry name" value="SECRETED PHOSPHOPROTEIN 24"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15444:SF4">
        <property type="entry name" value="SECRETED PHOSPHOPROTEIN 24"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07448">
        <property type="entry name" value="Spp-24"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
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    <feature type="chain" id="PRO_5035302749" description="Secreted phosphoprotein 24" evidence="10">
        <location>
            <begin position="31"/>
            <end position="212"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020365"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029627"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006101.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="212" mass="24323" checksum="85DE942E5E48030B" modified="2022-05-25" version="3">IISRMEKMMMMMMKILIMFALGTNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSSYLFRAFRSSLKRVEVLDENSLVMNLEFSIRETTCRRDSGEDPATCAFQRDYYVPTAVCRSTVKVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSRKWRNNSPFGLTPDESTSEQFYDQSLEIMRRVLPPGNRRYPNHQHRARINADFE</sequence>
</entry>
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    <accession>A0A096N1Z3</accession>
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        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix 4</fullName>
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        <name evidence="3" type="primary">SRRM4</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003907233.5"/>
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    <dbReference type="Ensembl" id="ENSPANT00000015702.3">
        <property type="protein sequence ID" value="ENSPANP00000006334.3"/>
        <property type="gene ID" value="ENSPANG00000022544.4"/>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="Bgee" id="ENSPANG00000022544">
        <property type="expression patterns" value="Expressed in pineal body and 18 other cell types or tissues"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR34755:SF1">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF15230">
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        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="35"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="264"/>
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        </location>
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            <begin position="107"/>
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            <begin position="203"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N2P3</accession>
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        <submittedName>
            <fullName evidence="8">Killer cell lectin like receptor G2</fullName>
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        <name evidence="8" type="primary">KLRG2</name>
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            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N2P3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006587"/>
    <dbReference type="Ensembl" id="ENSPANT00000024608.3">
        <property type="protein sequence ID" value="ENSPANP00000006587.2"/>
        <property type="gene ID" value="ENSPANG00000025362.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162997"/>
    <dbReference type="HOGENOM" id="CLU_049894_8_6_1"/>
    <dbReference type="OMA" id="EEHCYYF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025362">
        <property type="expression patterns" value="Expressed in cornea"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043318">
        <property type="entry name" value="KLRG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47606">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47606:SF1">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="298"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006587.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="407" mass="42801" checksum="000EC13E1F3AFD0A" modified="2022-05-25" version="2">MEGWEAAPGGQAGAELPMEPAGSLVPGLEQPQVPEKAQQPEGPESSPSPSRAMKKAAGAGREPSSERQLPSPRPGTPRVPPLSLDYGVCPEPPSPGPASVKLPRNGQAPGAEPAPGAWAPMELQVDVLVKPVGAAGGSRTPSPRPSTRFLTVPVPESPAFSRQADPAHQQLLPRASSLSGTWGRGSTLAAAGTESGRDAEGRASPVEGSSPGSPTCCRCKELGLEKEDAALLPRAGLEGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQPCPPGWVLSEEHCYYFSVEAQSWEASQAFCSAYHATLPLLRHTQDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGKDNPDINCGALDEGTLVAANCSTPRPWVCAKGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N339</accession>
    <name>A0A096N339_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Stromelysin-1</fullName>
            <ecNumber evidence="19">3.4.24.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Matrix metalloproteinase-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">MMP3</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Preferential cleavage where P1', P2' and P3' are hydrophobic residues.</text>
            <dbReference type="EC" id="3.4.24.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="24">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="24">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.17" evidence="19"/>
    <dbReference type="RefSeq" id="XP_031509749.1">
        <property type="nucleotide sequence ID" value="XM_031653889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N339"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006745"/>
    <dbReference type="Ensembl" id="ENSPANT00000004481.3">
        <property type="protein sequence ID" value="ENSPANP00000006745.2"/>
        <property type="gene ID" value="ENSPANG00000014348.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000789"/>
    <dbReference type="KEGG" id="panu:101000789"/>
    <dbReference type="CTD" id="4314"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159759"/>
    <dbReference type="HOGENOM" id="CLU_015489_6_0_1"/>
    <dbReference type="OMA" id="NFVQQYL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014348">
        <property type="expression patterns" value="Expressed in duodenum and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    </evidence>
    <sequence length="477" mass="54115" checksum="7B29D7AA0C74AE8E" modified="2018-02-28" version="2">MKSLPILLLLCVAVCSAYPLDGGARDEDTSMNFVQQYLENYYDLEKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFTTFPGIPKWRKTHLTYRIVNYTQDLPEDAIDSAIEKAVKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGINLFLVAAHELGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPGSPETPLVPTDPVPPAPGMPATCDPALSFDAVSTLRGEILFFKDRHFWRKSLRKLEPDLYLISSFWPSLPSGMDAAYEVTSKDLVFIFKGNQFWAIRGNEVQAGYPKRIHTLGFPPTVRKIDAAFSDKEKKKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N417</accession>
    <name>A0A096N417_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ring finger protein 19B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RNF19B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096N417"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007113"/>
    <dbReference type="Ensembl" id="ENSPANT00000017338.3">
        <property type="protein sequence ID" value="ENSPANP00000007113.2"/>
        <property type="gene ID" value="ENSPANG00000025214.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158451"/>
    <dbReference type="HOGENOM" id="CLU_016793_3_0_1"/>
    <dbReference type="OMA" id="EQEQTCK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025214">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N417">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044194">
        <property type="term" value="C:cytolytic granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007113.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="436" mass="45676" checksum="2257294659EB525C" modified="2022-05-25" version="2">MNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N6P1</accession>
    <name>A0A096N6P1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Interleukin-1 receptor accessory protein-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">X-linked interleukin-1 receptor accessory protein-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">IL1RAPL1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the interleukin-1 receptor family.</text>
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        <property type="nucleotide sequence ID" value="XM_003917532.5"/>
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        <property type="protein sequence ID" value="ENSPANP00000008158.2"/>
        <property type="gene ID" value="ENSPANG00000007585.3"/>
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    <dbReference type="GeneID" id="101019520"/>
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    <dbReference type="eggNOG" id="KOG3971">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome X"/>
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    <dbReference type="Bgee" id="ENSPANG00000007585">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 27 other cell types or tissues"/>
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        <property type="term" value="C:axon"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:dendrite"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:glutamatergic synapse"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of exocytosis"/>
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        <property type="term" value="P:regulation of postsynapse organization"/>
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        <property type="term" value="P:regulation of presynapse assembly"/>
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        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:trans-synaptic signaling by trans-synaptic complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05896">
        <property type="entry name" value="Ig1_IL1RAPL-1_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000188">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:001486">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000220">
        <property type="entry name" value="X-linked interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.10140:FF:000004">
        <property type="entry name" value="X-linked interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
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    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
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    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
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    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
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        <property type="entry name" value="TIR_dom"/>
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    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
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        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1"/>
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        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00047">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
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    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0732">Signal</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014175750" description="Interleukin-1 receptor accessory protein-like 1" evidence="25">
        <location>
            <begin position="19"/>
            <end position="696"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="360"/>
            <end position="381"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="6"/>
            <end position="134"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="162"/>
            <end position="232"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="242"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="26">
        <location>
            <begin position="403"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013309"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032846"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="696" mass="79953" checksum="324042B5FCF71A05" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N733</accession>
    <name>A0A096N733_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">X-C motif chemokine receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">XCR1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894590.1">
        <property type="nucleotide sequence ID" value="XM_003894541.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003894591.1">
        <property type="nucleotide sequence ID" value="XM_003894542.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N733"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008316"/>
    <dbReference type="Ensembl" id="ENSPANT00000018130.3">
        <property type="protein sequence ID" value="ENSPANP00000008316.1"/>
        <property type="gene ID" value="ENSPANG00000005627.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101008087"/>
    <dbReference type="KEGG" id="panu:101008087"/>
    <dbReference type="CTD" id="2829"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267168"/>
    <dbReference type="HOGENOM" id="CLU_009579_8_3_1"/>
    <dbReference type="OMA" id="RSHTKNR"/>
    <dbReference type="OrthoDB" id="10015690at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005627">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15182">
        <property type="entry name" value="7tmA_XCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000130">
        <property type="entry name" value="Chemokine (C-C motif) receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005393">
        <property type="entry name" value="Chemokine_XCR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF730">
        <property type="entry name" value="CHEMOKINE XC RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01568">
        <property type="entry name" value="LYMPHOTACTNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="48"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="333" mass="38463" checksum="ED3518CBD621305B" modified="2014-11-26" version="1">MESSGNPETTTFFYYDLQSQLCENQAWAFATLATTILYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWGWVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLSTLRVPTLRCRVLVTTAVWVASILSSILDAIFHKVLSSGCDYSELTWYLTSVYQHNLFFLLSLGIILFCYVEILRTLFRSRSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFHTQIIRSCEAKHQLEYALLICRNLAFSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPAPIPHSPGAFAYEGASFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N9U5</accession>
    <name>A0A096N9U5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096N9U5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009431"/>
    <dbReference type="Ensembl" id="ENSPANT00000018173.3">
        <property type="protein sequence ID" value="ENSPANP00000009431.3"/>
        <property type="gene ID" value="ENSPANG00000002728.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017491"/>
    <dbReference type="HOGENOM" id="CLU_090139_1_0_1"/>
    <dbReference type="OMA" id="WASSETH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002728">
        <property type="expression patterns" value="Expressed in axillary lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009431.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="151" mass="17221" checksum="07F946F359CD6060" modified="2022-05-25" version="3">MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRFLKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESQIHHLARYYKTKRVLPPNWKYESSIASALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NAD3</accession>
    <name>A0A096NAD3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Piwi like RNA-mediated silencing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIWIL4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003910613.2">
        <property type="nucleotide sequence ID" value="XM_003910564.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NAD3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009641"/>
    <dbReference type="Ensembl" id="ENSPANT00000017401.3">
        <property type="protein sequence ID" value="ENSPANP00000009641.2"/>
        <property type="gene ID" value="ENSPANG00000016066.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010312"/>
    <dbReference type="KEGG" id="panu:101010312"/>
    <dbReference type="CTD" id="143689"/>
    <dbReference type="eggNOG" id="KOG1042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183200"/>
    <dbReference type="HOGENOM" id="CLU_008813_2_0_1"/>
    <dbReference type="OMA" id="WSKDMRN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016066">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NAD3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034584">
        <property type="term" value="F:piRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010669">
        <property type="term" value="P:epithelial structure maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000217">
        <property type="entry name" value="Piwi like RNA-mediated gene silencing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="12">
        <location>
            <begin position="272"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="13">
        <location>
            <begin position="546"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009641.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="852" mass="96372" checksum="73E9DA830A482A7F" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCH0</accession>
    <name>A0A096NCH0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T cell leukemia homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TLX3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003900560.2">
        <property type="nucleotide sequence ID" value="XM_003900511.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NCH0"/>
    <dbReference type="SMR" id="A0A096NCH0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010513"/>
    <dbReference type="Ensembl" id="ENSPANT00000021133.3">
        <property type="protein sequence ID" value="ENSPANP00000010513.2"/>
        <property type="gene ID" value="ENSPANG00000000216.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022319"/>
    <dbReference type="KEGG" id="panu:101022319"/>
    <dbReference type="CTD" id="30012"/>
    <dbReference type="eggNOG" id="KOG0488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160629"/>
    <dbReference type="HOGENOM" id="CLU_053409_1_0_1"/>
    <dbReference type="OMA" id="TPHQHEP"/>
    <dbReference type="OrthoDB" id="9451579at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000216">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097154">
        <property type="term" value="P:GABAergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002087">
        <property type="term" value="P:regulation of respiratory gaseous exchange by nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000040">
        <property type="entry name" value="T-cell leukemia homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042247">
        <property type="entry name" value="TLX1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921">
        <property type="entry name" value="IP01054P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921:SF1">
        <property type="entry name" value="T-CELL LEUKEMIA HOMEOBOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010513.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="338" mass="36981" checksum="7FDE5CE5C4440564" modified="2022-05-25" version="2">MTQSLSGPRTLGKVSVRREAPGAPWPRRNRDPAASPPSPAQPFRPPRMEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDE9</accession>
    <name>A0A096NDE9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neprilysin</fullName>
            <ecNumber evidence="5">3.4.24.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Atriopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Enkephalinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Neutral endopeptidase 24.11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Skin fibroblast elastase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">MME</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="30">Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.</text>
            <dbReference type="EC" id="3.4.24.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucine</text>
            <dbReference type="Rhea" id="RHEA:71479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:147362"/>
            <dbReference type="ChEBI" id="CHEBI:190705"/>
            <dbReference type="ChEBI" id="CHEBI:190707"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:71480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucine</text>
            <dbReference type="Rhea" id="RHEA:71475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:147362"/>
            <dbReference type="ChEBI" id="CHEBI:190704"/>
            <dbReference type="ChEBI" id="CHEBI:190706"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:71476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2</text>
            <dbReference type="Rhea" id="RHEA:71467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:190692"/>
            <dbReference type="ChEBI" id="CHEBI:190695"/>
            <dbReference type="ChEBI" id="CHEBI:190698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:71468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2</text>
            <dbReference type="Rhea" id="RHEA:71459"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:190692"/>
            <dbReference type="ChEBI" id="CHEBI:190693"/>
            <dbReference type="ChEBI" id="CHEBI:190700"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:71460"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.11" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031519500.1">
        <property type="nucleotide sequence ID" value="XM_031663640.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519501.1">
        <property type="nucleotide sequence ID" value="XM_031663641.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519502.1">
        <property type="nucleotide sequence ID" value="XM_031663642.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519503.1">
        <property type="nucleotide sequence ID" value="XM_031663643.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519504.1">
        <property type="nucleotide sequence ID" value="XM_031663644.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519505.1">
        <property type="nucleotide sequence ID" value="XM_031663645.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519506.1">
        <property type="nucleotide sequence ID" value="XM_031663646.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519507.1">
        <property type="nucleotide sequence ID" value="XM_031663647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDE9"/>
    <dbReference type="SMR" id="A0A096NDE9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010893"/>
    <dbReference type="GlyCosmos" id="A0A096NDE9">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000022731.3">
        <property type="protein sequence ID" value="ENSPANP00000010893.3"/>
        <property type="gene ID" value="ENSPANG00000005579.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009712"/>
    <dbReference type="KEGG" id="panu:101009712"/>
    <dbReference type="CTD" id="4311"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156745"/>
    <dbReference type="HOGENOM" id="CLU_006187_4_1_1"/>
    <dbReference type="OMA" id="RNHDAWY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005579">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 44 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDE9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044306">
        <property type="term" value="C:neuron projection terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021764">
        <property type="term" value="P:amygdala development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150094">
        <property type="term" value="P:amyloid-beta clearance by cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002003">
        <property type="term" value="P:angiotensin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010815">
        <property type="term" value="P:bradykinin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071345">
        <property type="term" value="P:cellular response to cytokine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046449">
        <property type="term" value="P:creatinine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042447">
        <property type="term" value="P:hormone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061837">
        <property type="term" value="P:neuropeptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900273">
        <property type="term" value="P:positive regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090399">
        <property type="term" value="P:replicative senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010814">
        <property type="term" value="P:substance P catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1380.10:FF:000002">
        <property type="entry name" value="Membrane metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF114">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="34">
        <location>
            <begin position="79"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="33">
        <location>
            <begin position="543"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00032584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00054547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010893.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="750" mass="85471" checksum="39F40F40A7BA51D5" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDJ9</accession>
    <name>A0A096NDJ9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Src kinase-associated phosphoprotein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Src family-associated phosphoprotein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SKAP2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021791633.1">
        <property type="nucleotide sequence ID" value="XM_021935941.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021791634.1">
        <property type="nucleotide sequence ID" value="XM_021935942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDJ9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010945"/>
    <dbReference type="Ensembl" id="ENSPANT00000027943.3">
        <property type="protein sequence ID" value="ENSPANP00000010945.2"/>
        <property type="gene ID" value="ENSPANG00000006185.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024754"/>
    <dbReference type="KEGG" id="panu:101024754"/>
    <dbReference type="CTD" id="8935"/>
    <dbReference type="eggNOG" id="ENOG502QVFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017856"/>
    <dbReference type="HOGENOM" id="CLU_062032_0_0_1"/>
    <dbReference type="OMA" id="ASDRCDK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006185">
        <property type="expression patterns" value="Expressed in urinary bladder and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13381">
        <property type="entry name" value="PH_Skap-hom_Skap2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12045">
        <property type="entry name" value="SH3_SKAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000194">
        <property type="entry name" value="Putative src kinase-associated phosphoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000097">
        <property type="entry name" value="Putative src kinase-associated phosphoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF2">
        <property type="entry name" value="SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="116"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010945.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="359" mass="41274" checksum="D3E30574FBF1F0F2" modified="2018-02-28" version="2">MPNPSSTSSPYPLPEEIRNLLADVETFVADTLKGENLSKKAKEKRESLIKKIKDVKSVYLQEFQDKGDAEDGEEYDDPFARPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFALDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPPTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDY0</accession>
    <name>A0A096NDY0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CLK4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003900662.1">
        <property type="nucleotide sequence ID" value="XM_003900613.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017815678.1">
        <property type="nucleotide sequence ID" value="XM_017960189.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDY0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011080"/>
    <dbReference type="Ensembl" id="ENSPANT00000001815.3">
        <property type="protein sequence ID" value="ENSPANP00000011080.1"/>
        <property type="gene ID" value="ENSPANG00000014774.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009204"/>
    <dbReference type="KEGG" id="panu:101009204"/>
    <dbReference type="CTD" id="57396"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160245"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_16_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014774">
        <property type="expression patterns" value="Expressed in optic disc and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDY0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14213">
        <property type="entry name" value="PKc_CLK1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000061">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000220">
        <property type="entry name" value="dual specificity protein kinase CLK4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE CLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="159"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="481" mass="57458" checksum="94A7203B137AB819" modified="2014-11-26" version="1">MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPCHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGN0</accession>
    <name>A0A096NGN0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hyccin PI4KA lipid kinase complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HYCC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NGN0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012114"/>
    <dbReference type="Ensembl" id="ENSPANT00000026407.3">
        <property type="protein sequence ID" value="ENSPANP00000012114.1"/>
        <property type="gene ID" value="ENSPANG00000022515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009611"/>
    <dbReference type="KEGG" id="panu:101009611"/>
    <dbReference type="CTD" id="84668"/>
    <dbReference type="eggNOG" id="KOG4688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011295"/>
    <dbReference type="HOGENOM" id="CLU_027457_3_0_1"/>
    <dbReference type="OMA" id="LPMKYQA"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022515">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NGN0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF4">
        <property type="entry name" value="HYCCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="521" mass="57606" checksum="5AF3C3BD889FBE4B" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGQ1</accession>
    <name>A0A096NGQ1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TBP</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898469.2">
        <property type="nucleotide sequence ID" value="XM_003898420.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009204725.2">
        <property type="nucleotide sequence ID" value="XM_009206461.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813986.2">
        <property type="nucleotide sequence ID" value="XM_017958497.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813987.2">
        <property type="nucleotide sequence ID" value="XM_017958498.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017813988.2">
        <property type="nucleotide sequence ID" value="XM_017958499.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGQ1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012137"/>
    <dbReference type="Ensembl" id="ENSPANT00000006388.4">
        <property type="protein sequence ID" value="ENSPANP00000012137.2"/>
        <property type="gene ID" value="ENSPANG00000000569.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101006949"/>
    <dbReference type="KEGG" id="panu:101006949"/>
    <dbReference type="CTD" id="6908"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157474"/>
    <dbReference type="OMA" id="NMDQNNS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000569">
        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NGQ1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001674">
        <property type="term" value="C:female germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005668">
        <property type="term" value="C:RNA polymerase transcription factor SL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017162">
        <property type="term" value="F:aryl hydrocarbon receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001093">
        <property type="term" value="F:TFIIB-class transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012137.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="334" mass="37069" checksum="8834A30693C612F2" modified="2022-05-25" version="2">MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVATAAVQQSASQQTTQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPLTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHF7</accession>
    <name>A0A096NHF7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynactin subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dynactin subunit p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DCTN5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. Within the complex DCTN6 forms a heterodimer with DCTN5. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NHF7"/>
    <dbReference type="Ensembl" id="ENSPANT00000012374.3">
        <property type="protein sequence ID" value="ENSPANP00000012405.3"/>
        <property type="gene ID" value="ENSPANG00000018525.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015360"/>
    <dbReference type="HOGENOM" id="CLU_088622_2_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018525">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NHF7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000014">
        <property type="entry name" value="dynactin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012405.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="152" mass="16639" checksum="E61398F012D63D03" modified="2022-05-25" version="3">MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRHCVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTVFSGCPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIF8</accession>
    <name>A0A096NIF8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YIPF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">YIP1 family member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">YIPF3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NIF8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012756"/>
    <dbReference type="Ensembl" id="ENSPANT00000015062.3">
        <property type="protein sequence ID" value="ENSPANP00000012756.2"/>
        <property type="gene ID" value="ENSPANG00000023627.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153766"/>
    <dbReference type="HOGENOM" id="CLU_068070_0_0_1"/>
    <dbReference type="OMA" id="HCIVLFV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023627">
        <property type="expression patterns" value="Expressed in pancreas and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NIF8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF14">
        <property type="entry name" value="PROTEIN YIPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012756.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="356" mass="38845" checksum="3FDDB9B7278D16F5" modified="2018-02-28" version="2">MATTAAPAGGARNGAGPEWGGFEENIQEPLSSQGGGSAVIDMENMDDTSGSSFEDMGELHQRLREEEVDADAADAAAAEEEDGEFLGMKGFKGQLSRQVADQMWQAGKRQASRAFSLYANIDILRPYFDVEPAQVRSRLLESMIPIKMVNFPQKIAGELYGPLMLVFTLVAILLHGMKTSDTIIREGTLMGTAIGTCFGYWLGVSSFIYFLAYLCNAQITMLQMLALLGYGLFGHCIVLFITYNIHLHALFYLFWLLVGGLSTLRMVAVLVSRTVGPTQRLLLCGTLAALHMLFLLYLHFAYHKVVEGILDTLEGPNIPPIQRVPRDIPAVLAAARLPTTILNATAKAVAVTLQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIR3</accession>
    <name>A0A096NIR3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Bis(5'-adenosyl)-triphosphatase ENPP4</fullName>
            <ecNumber evidence="4">3.6.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">AP3A hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Bis(5'-adenosyl)-triphosphatase enpp4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ectonucleotide pyrophosphatase/phosphodiesterase family member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ENPP4</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003897732.1">
        <property type="nucleotide sequence ID" value="XM_003897683.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009203562.1">
        <property type="nucleotide sequence ID" value="XM_009205298.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009203563.1">
        <property type="nucleotide sequence ID" value="XM_009205299.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009203564.1">
        <property type="nucleotide sequence ID" value="XM_009205300.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NIR3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012861"/>
    <dbReference type="Ensembl" id="ENSPANT00000013009.3">
        <property type="protein sequence ID" value="ENSPANP00000012861.1"/>
        <property type="gene ID" value="ENSPANG00000000926.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007527"/>
    <dbReference type="KEGG" id="panu:101007527"/>
    <dbReference type="CTD" id="22875"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158831"/>
    <dbReference type="HOGENOM" id="CLU_017594_1_2_1"/>
    <dbReference type="OMA" id="DVCIDHS"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000926">
        <property type="expression patterns" value="Expressed in pyloric antrum and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030194">
        <property type="term" value="P:positive regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046130">
        <property type="term" value="P:purine ribonucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000035">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase 4 (Putative)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000004">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF79">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE ENPP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 24" id="KW-0732">Signal</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922214" description="Bis(5'-adenosyl)-triphosphatase ENPP4" evidence="24">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="453" mass="51497" checksum="DCEAC31730E738A8" modified="2014-11-26" version="1">MKLLVILLFSGLITGCRSDSSSSLPPKLLLVSFDGFRADYLKNYEFPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDAVTKKHFSDSNDKDPFWWNEAVPIWVTNQLQENRSSAAAMWPGTDVPIHNTTSSYFMNYNSSVSFEERLNNITMWLNNSNPPVTFATLYWEEPDASGHKYGPEDKENMSRVLKKIDDLIGDLVQKLKMLGLWENLNVIITSDHGMTQCSQDRLINLDGCIDHSYYTLIDLSPVAAILPKINRTEVYNKLKNCNSHMNVYLKEDIPNRFYYQHNDRIQPIILVANEGWTIVLNKSSQKLGDHGYDNSLPSMHPFLAAHGPAFHKGYKHSTINIVDIYPMMCHILGLKPHPNNGTFGHTKCLLVDQWCINLPEAIAIVVGSLLVLTTLTCLIIIMQNRLSVPRPFSRLQLQEDDDDPLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NKW2</accession>
    <name>A0A096NKW2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNA helicase Mov10l1</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MOV10L1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PIWIL1. Interacts with PIWIL2. Interacts with PIWIL4. Interacts with HSPA2. Interacts with PLD6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003905782.2">
        <property type="nucleotide sequence ID" value="XM_003905733.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NKW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013619"/>
    <dbReference type="Ensembl" id="ENSPANT00000023514.3">
        <property type="protein sequence ID" value="ENSPANP00000013619.3"/>
        <property type="gene ID" value="ENSPANG00000006819.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997495"/>
    <dbReference type="KEGG" id="panu:100997495"/>
    <dbReference type="CTD" id="54456"/>
    <dbReference type="eggNOG" id="KOG1804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160150"/>
    <dbReference type="HOGENOM" id="CLU_001666_3_1_1"/>
    <dbReference type="OMA" id="VDDCWRH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006819">
        <property type="expression patterns" value="Expressed in testis and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NKW2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18078">
        <property type="entry name" value="DEXXQc_Mov10L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000999">
        <property type="entry name" value="Mov10 like RISC complex RNA helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000864">
        <property type="entry name" value="Mov10-like RISC complex RNA helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035231085" description="RNA helicase Mov10l1" evidence="15">
        <location>
            <begin position="19"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="18">
        <location>
            <begin position="552"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="16">
        <location>
            <begin position="745"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="16">
        <location>
            <begin position="856"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="17">
        <location>
            <begin position="945"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013619.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1211" mass="135634" checksum="E5A7FBEDDB528306" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLR8</accession>
    <name>A0A096NLR8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tumor necrosis factor receptor superfamily member 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">B-cell maturation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TNFRSF17</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003916609.2">
        <property type="nucleotide sequence ID" value="XM_003916560.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLR8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013926"/>
    <dbReference type="Ensembl" id="ENSPANT00000006483.3">
        <property type="protein sequence ID" value="ENSPANP00000013926.1"/>
        <property type="gene ID" value="ENSPANG00000018610.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017363"/>
    <dbReference type="KEGG" id="panu:101017363"/>
    <dbReference type="CTD" id="608"/>
    <dbReference type="eggNOG" id="ENOG502SF2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154485"/>
    <dbReference type="HOGENOM" id="CLU_131588_0_0_1"/>
    <dbReference type="OMA" id="CHLRCSN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018610">
        <property type="expression patterns" value="Expressed in duodenum and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLR8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002260">
        <property type="term" value="P:lymphocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13414">
        <property type="entry name" value="TNFRSF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1290.10:FF:000003">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily member 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1290.10">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015337">
        <property type="entry name" value="BCMA_Tall-1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043521">
        <property type="entry name" value="TNFR_13C/17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022320">
        <property type="entry name" value="TNFR_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20437">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 13/17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20437:SF0">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09257">
        <property type="entry name" value="BCMA-Tall_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01967">
        <property type="entry name" value="TNFACTORR17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="BCMA TALL-1 binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="20229" checksum="B5278F18663331C4" modified="2014-11-26" version="1">MLQMARQCSQNEYFDSLLHDCKPCQLRCSSTPPLTCQRYCNASMTNSVKGMNAILWTCLGLSLIISLAVFVLTFLLRKMSSEPLKDEFKNTGSGLLGMANIDLEKGRTGDEIVLPRGLEYTVEECTCEDCIKNKPKVDSDHCFPLPAMEEGATILVTTKTNDYCNSLPAALSVTEIEKSISAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMN6</accession>
    <name>A0A096NMN6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Neuroplastin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Stromal cell-derived receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">NPTN</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with ATP2B1; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with XKR8; promoting its localization at the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
            <location evidence="14">Postsynaptic density</location>
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        <property type="component" value="Chromosome 7"/>
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        <property type="expression patterns" value="Expressed in adrenal cortex and 66 other cell types or tissues"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:dendrite"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:immunological synapse"/>
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        <property type="term" value="C:postsynaptic density"/>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
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        <property type="term" value="P:modulation of chemical synaptic transmission"/>
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        <property type="entry name" value="Neuroplastin a"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="TyrPK_CSF1-R"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
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    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 21" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922423" description="Neuroplastin" evidence="21">
        <location>
            <begin position="29"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
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            <begin position="25"/>
            <end position="134"/>
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            <begin position="148"/>
            <end position="235"/>
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            <begin position="238"/>
            <end position="329"/>
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        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023018"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00034105"/>
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            <dbReference type="ARBA" id="ARBA00058598"/>
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            <dbReference type="ARBA" id="ARBA00069991"/>
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            <dbReference type="ARBA" id="ARBA00081203"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="398" mass="44387" checksum="5109E3C03B4967EA" modified="2014-11-26" version="1">MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQK3</accession>
    <name>A0A096NQK3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CLCN4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQK3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015309"/>
    <dbReference type="Ensembl" id="ENSPANT00000014275.3">
        <property type="protein sequence ID" value="ENSPANP00000015309.2"/>
        <property type="gene ID" value="ENSPANG00000020606.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158265"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_1_1"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020606">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQK3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002246">
        <property type="entry name" value="Cl_channel-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF2">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01115">
        <property type="entry name" value="CLCHANNEL4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0129">CBS domain</keyword>
    <keyword evidence="13 15" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="627"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="724"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015309.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="787" mass="87863" checksum="B9D1E1263093F993" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQX3</accession>
    <name>A0A096NQX3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Coiled-coil domain-containing protein 139</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PUS10</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:57877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42533"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with components of the microprocessor complex DROSHA and DGCR8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="RefSeq" id="XP_009182519.2">
        <property type="nucleotide sequence ID" value="XM_009184255.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021780542.1">
        <property type="nucleotide sequence ID" value="XM_021924850.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021780543.1">
        <property type="nucleotide sequence ID" value="XM_021924851.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021780544.1">
        <property type="nucleotide sequence ID" value="XM_021924852.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021780545.1">
        <property type="nucleotide sequence ID" value="XM_021924853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQX3"/>
    <dbReference type="SMR" id="A0A096NQX3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015437"/>
    <dbReference type="Ensembl" id="ENSPANT00000022548.3">
        <property type="protein sequence ID" value="ENSPANP00000015437.2"/>
        <property type="gene ID" value="ENSPANG00000018036.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003550"/>
    <dbReference type="KEGG" id="panu:101003550"/>
    <dbReference type="CTD" id="150962"/>
    <dbReference type="eggNOG" id="KOG2364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007529"/>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_1"/>
    <dbReference type="OMA" id="LVISCQR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018036">
        <property type="expression patterns" value="Expressed in zone of skin and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQX3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2050:FF:000001">
        <property type="entry name" value="putative tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="23">
        <location>
            <begin position="109"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="24">
        <location>
            <begin position="289"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015437.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="529" mass="60212" checksum="49F67447BBA94606" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUZ3</accession>
    <name>A0A096NUZ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XKR7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904941.1">
        <property type="nucleotide sequence ID" value="XM_003904892.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUZ3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016868"/>
    <dbReference type="Ensembl" id="ENSPANT00000003857.4">
        <property type="protein sequence ID" value="ENSPANP00000016868.1"/>
        <property type="gene ID" value="ENSPANG00000016048.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101016462"/>
    <dbReference type="KEGG" id="panu:101016462"/>
    <dbReference type="CTD" id="343702"/>
    <dbReference type="eggNOG" id="KOG4790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282533"/>
    <dbReference type="OMA" id="AMVQILW"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016048">
        <property type="expression patterns" value="Expressed in cerebellum"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF7">
        <property type="entry name" value="XK-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="579" mass="63614" checksum="3EDE5520BF57A817" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NV73</accession>
    <name>A0A096NV73_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAPK-interacting and spindle-stabilizing protein-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitogen-activated protein kinase 1-interacting protein 1-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MAPK1IP1L</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MISS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901875.1">
        <property type="nucleotide sequence ID" value="XM_003901826.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021796935.1">
        <property type="nucleotide sequence ID" value="XM_021941243.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NV73"/>
    <dbReference type="SMR" id="A0A096NV73"/>
    <dbReference type="Ensembl" id="ENSPANT00000023796.3">
        <property type="protein sequence ID" value="ENSPANP00000016948.2"/>
        <property type="gene ID" value="ENSPANG00000018091.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997462"/>
    <dbReference type="KEGG" id="panu:100997462"/>
    <dbReference type="CTD" id="93487"/>
    <dbReference type="eggNOG" id="ENOG502RYAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111340"/>
    <dbReference type="HOGENOM" id="CLU_063887_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018091">
        <property type="expression patterns" value="Expressed in esophagus and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NV73">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031653">
        <property type="entry name" value="MISS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35973">
        <property type="entry name" value="MAPK-INTERACTING AND SPINDLE-STABILIZING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35973:SF1">
        <property type="entry name" value="MAPK-INTERACTING AND SPINDLE-STABILIZING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15822">
        <property type="entry name" value="MISS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016948.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="245" mass="24252" checksum="868D76EAA9A53E0D" modified="2018-02-28" version="2">MSDEFSLADALPEHSPAKTSAVSNTKPGQPPQGWPGSSPWNNPSAPPSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGAPPMPGGPHSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NWP3</accession>
    <name>A0A096NWP3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">GRIN1</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20 28">Postsynaptic cell membrane</location>
            <topology evidence="20 28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009186049.1">
        <property type="nucleotide sequence ID" value="XM_009187785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NWP3"/>
    <dbReference type="SMR" id="A0A096NWP3"/>
    <dbReference type="Ensembl" id="ENSPANT00000028752.3">
        <property type="protein sequence ID" value="ENSPANP00000017471.1"/>
        <property type="gene ID" value="ENSPANG00000026295.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001959"/>
    <dbReference type="CTD" id="2902"/>
    <dbReference type="eggNOG" id="KOG4440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158016"/>
    <dbReference type="HOGENOM" id="CLU_007257_2_0_1"/>
    <dbReference type="OMA" id="FANNTPD"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026295">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 33 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NWP3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
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        <property type="term" value="C:postsynaptic density membrane"/>
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        <property type="term" value="F:ligand-gated sodium channel activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:calcium ion transmembrane import into cytosol"/>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="Glu/Gly-bd"/>
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        <property type="entry name" value="Iono_Glu_rcpt_met"/>
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        <property type="entry name" value="Peripla_BP_I"/>
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        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANF_receptor"/>
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        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NMDARECEPTOR"/>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PBPe"/>
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        <property type="entry name" value="Periplasmic binding protein-like I"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
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    <keyword evidence="12 28" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 28" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="15 28" id="KW-0675">Receptor</keyword>
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    <keyword evidence="11 28" id="KW-0770">Synapse</keyword>
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    <keyword evidence="10 28" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="7" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="23"/>
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            <begin position="583"/>
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    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="656"/>
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    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="834"/>
            <end position="858"/>
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        <location>
            <begin position="454"/>
            <end position="816"/>
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            <begin position="460"/>
            <end position="528"/>
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        <location>
            <begin position="910"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
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            <begin position="937"/>
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    <feature type="binding site" evidence="25">
        <location>
            <position position="537"/>
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        <ligand>
            <name>L-glutamate</name>
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    <feature type="binding site" evidence="25">
        <location>
            <position position="539"/>
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        <ligand>
            <name>L-glutamate</name>
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    <feature type="binding site" evidence="25">
        <location>
            <position position="544"/>
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        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
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    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="709"/>
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        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
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    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="26">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="26">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="26">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="27">
        <location>
            <begin position="765"/>
            <end position="819"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005374"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="959" mass="107909" checksum="C7F52E8535F521EE" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXB4</accession>
    <name>A0A096NXB4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IFT52</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003904773.1">
        <property type="nucleotide sequence ID" value="XM_003904724.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214359.1">
        <property type="nucleotide sequence ID" value="XM_009216095.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017800280.1">
        <property type="nucleotide sequence ID" value="XM_017944791.3"/>
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        <property type="nucleotide sequence ID" value="XM_017944792.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A096NXB4"/>
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        <property type="protein sequence ID" value="ENSPANP00000017708.1"/>
        <property type="gene ID" value="ENSPANG00000021782.3"/>
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    <dbReference type="GeneID" id="101004826"/>
    <dbReference type="KEGG" id="panu:101004826"/>
    <dbReference type="CTD" id="51098"/>
    <dbReference type="eggNOG" id="KOG3861">
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    <dbReference type="GeneTree" id="ENSGT00390000011581"/>
    <dbReference type="HOGENOM" id="CLU_027692_0_0_1"/>
    <dbReference type="OMA" id="NWNVEQN"/>
    <dbReference type="OrthoDB" id="10259368at2759"/>
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        <property type="component" value="Chromosome 16"/>
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        <property type="term" value="C:photoreceptor connecting cilium"/>
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        <property type="term" value="P:dorsal/ventral pattern formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:embryonic digit morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010839">
        <property type="term" value="P:negative regulation of keratinocyte proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001841">
        <property type="term" value="P:neural tube formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070613">
        <property type="term" value="P:regulation of protein processing"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="269"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="437" mass="49644" checksum="7DE3617251BF36DF" modified="2014-11-26" version="1">MEKELRSTIVFNAYKKEIFTTNNGYKSMQKKLRSNWKIQSLKDEITSEKLNGVKLWITAGPREKFTAAEFEILKKYLDSGGDVLVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYHKYFHPKEALVSSGVLNREISRAAGKAVPGIIDEESSGNNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLNQIDAEDPEISDYMMLPYTATLSKRNRECLQESDEIPRDFTTLFDLSIFQLDTTSFHSVIEAHEQLNVKHEPLQLIQPQFETPLPTLQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHVFFQVVEFKKLNQEHDIDTSETAFQNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYJ3</accession>
    <name>A0A096NYJ3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Poly(ADP-ribose) polymerase family member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PARP9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894057.2">
        <property type="nucleotide sequence ID" value="XM_003894008.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003894058.2">
        <property type="nucleotide sequence ID" value="XM_003894009.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003894059.2">
        <property type="nucleotide sequence ID" value="XM_003894010.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYJ3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018156"/>
    <dbReference type="Ensembl" id="ENSPANT00000013131.3">
        <property type="protein sequence ID" value="ENSPANP00000018156.2"/>
        <property type="gene ID" value="ENSPANG00000022289.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009028"/>
    <dbReference type="KEGG" id="panu:101009028"/>
    <dbReference type="CTD" id="83666"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158837"/>
    <dbReference type="HOGENOM" id="CLU_012160_0_0_1"/>
    <dbReference type="OMA" id="CTQIIVE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022289">
        <property type="expression patterns" value="Expressed in axillary lymph node and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NYJ3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072570">
        <property type="term" value="F:ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140802">
        <property type="term" value="F:NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097677">
        <property type="term" value="F:STAT family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060335">
        <property type="term" value="P:positive regulation of type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02903">
        <property type="entry name" value="Macro_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000010">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000011">
        <property type="entry name" value="Poly(ADP-ribose) polymerase family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000012">
        <property type="entry name" value="Protein mono-ADP-ribosyltransferase PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057049">
        <property type="entry name" value="PARP14_KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF70">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23254">
        <property type="entry name" value="KH_PARP14_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="15">
        <location>
            <begin position="72"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="15">
        <location>
            <begin position="271"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="14">
        <location>
            <begin position="593"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018156.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="818" mass="91974" checksum="6DB5BF2E1EDE0B0D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYU1</accession>
    <name>A0A096NYU1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Activating transcription factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ATF6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003893029.1">
        <property type="nucleotide sequence ID" value="XM_003892980.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NYU1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018257"/>
    <dbReference type="Ensembl" id="ENSPANT00000023970.3">
        <property type="protein sequence ID" value="ENSPANP00000018257.2"/>
        <property type="gene ID" value="ENSPANG00000021910.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014227"/>
    <dbReference type="KEGG" id="panu:101014227"/>
    <dbReference type="CTD" id="22926"/>
    <dbReference type="eggNOG" id="KOG4343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159221"/>
    <dbReference type="HOGENOM" id="CLU_026136_1_0_1"/>
    <dbReference type="OMA" id="WSINNQF"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021910">
        <property type="expression patterns" value="Expressed in thyroid gland and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036500">
        <property type="term" value="P:ATF6-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903893">
        <property type="term" value="P:positive regulation of ATF6-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14700">
        <property type="entry name" value="bZIP_ATF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000041">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-6 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051882">
        <property type="entry name" value="ATF_bZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164:SF1">
        <property type="entry name" value="CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="15">
        <location>
            <begin position="306"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018257.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="669" mass="74165" checksum="640E88174C20D157" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P152</accession>
    <name>A0A096P152_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZCCHC7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003911537.1">
        <property type="nucleotide sequence ID" value="XM_003911488.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186748.1">
        <property type="nucleotide sequence ID" value="XM_009188484.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009186749.1">
        <property type="nucleotide sequence ID" value="XM_009188485.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510188.1">
        <property type="nucleotide sequence ID" value="XM_031654328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510189.1">
        <property type="nucleotide sequence ID" value="XM_031654329.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510190.1">
        <property type="nucleotide sequence ID" value="XM_031654330.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031510191.1">
        <property type="nucleotide sequence ID" value="XM_031654331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P152"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019077"/>
    <dbReference type="Ensembl" id="ENSPANT00000026849.3">
        <property type="protein sequence ID" value="ENSPANP00000019077.1"/>
        <property type="gene ID" value="ENSPANG00000025472.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003582"/>
    <dbReference type="KEGG" id="panu:101003582"/>
    <dbReference type="CTD" id="84186"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183041"/>
    <dbReference type="HOGENOM" id="CLU_029787_0_0_1"/>
    <dbReference type="OMA" id="HFGHACI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025472">
        <property type="expression patterns" value="Expressed in mesenteric lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P152">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000020">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000041">
        <property type="entry name" value="Zinc finger CCHC domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="543" mass="63197" checksum="9EE65873C060F353" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P274</accession>
    <name>A0A096P274_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CTSL</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009187321.1">
        <property type="nucleotide sequence ID" value="XM_009189057.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P274"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019449"/>
    <dbReference type="Ensembl" id="ENSPANT00000024393.3">
        <property type="protein sequence ID" value="ENSPANP00000019449.2"/>
        <property type="gene ID" value="ENSPANG00000024640.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101015663"/>
    <dbReference type="KEGG" id="panu:101015663"/>
    <dbReference type="CTD" id="1514"/>
    <dbReference type="GeneTree" id="ENSGT00940000154367"/>
    <dbReference type="HOGENOM" id="CLU_012184_1_2_1"/>
    <dbReference type="OMA" id="VYYDEEC"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024640">
        <property type="expression patterns" value="Expressed in cornea and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043394">
        <property type="term" value="F:proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097655">
        <property type="term" value="F:serpin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097067">
        <property type="term" value="P:cellular response to thyroid hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039654">
        <property type="term" value="P:fusion of virus membrane with host endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019065">
        <property type="term" value="P:receptor-mediated endocytosis of virus by host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035235874" evidence="9">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="114"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019449.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="333" mass="37464" checksum="14CE5226392E0DD1" modified="2022-05-25" version="2">MNPTFILAAFCLGIASATLTFNHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5L9</accession>
    <name>A0A096P5L9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein KIF11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Kinesin-related motor protein Eg5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KIF11</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904049.3">
        <property type="nucleotide sequence ID" value="XM_003904000.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P5L9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020644"/>
    <dbReference type="Ensembl" id="ENSPANT00000009326.3">
        <property type="protein sequence ID" value="ENSPANP00000020644.2"/>
        <property type="gene ID" value="ENSPANG00000021559.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010258"/>
    <dbReference type="KEGG" id="panu:101010258"/>
    <dbReference type="CTD" id="3832"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155921"/>
    <dbReference type="HOGENOM" id="CLU_001485_33_4_1"/>
    <dbReference type="OMA" id="CQLISLW"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021559">
        <property type="expression patterns" value="Expressed in bone marrow and 45 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046602">
        <property type="term" value="P:regulation of mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000035">
        <property type="entry name" value="Kinesin-like protein KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF26">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="18">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="368"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1056" mass="119132" checksum="38291E074C78EEAD" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MVP9</accession>
    <name>A0A0A0MVP9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NACHT, LRR and PYD domains-containing protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Monarch-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PYRIN-containing APAF1-like protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NLRP12</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts (via pyrin domain) with ASC. Interacts (via pyrin domain) with FAF1 (via UBA domain). Interacts with MAP3K14; this interaction promotes proteasomal degradation of MAP3K14. Interacts with NOD2; this interaction promotes degradation of NOD2 through the ubiquitin-proteasome pathway. Interacts with HSPA1A and HSPA8. Interacts with HSP90AA1. Interacts with TRIM25; this interaction inhibits RIGI-mediated signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NLRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009193520.2">
        <property type="nucleotide sequence ID" value="XM_009195256.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVP9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007375"/>
    <dbReference type="Ensembl" id="ENSPANT00000020998.3">
        <property type="protein sequence ID" value="ENSPANP00000007375.3"/>
        <property type="gene ID" value="ENSPANG00000009037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137561"/>
    <dbReference type="CTD" id="91662"/>
    <dbReference type="eggNOG" id="ENOG502QS9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160873"/>
    <dbReference type="HOGENOM" id="CLU_002274_2_0_1"/>
    <dbReference type="OMA" id="TTAVYMF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009037">
        <property type="expression patterns" value="Expressed in bone marrow and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071345">
        <property type="term" value="P:cellular response to cytokine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032692">
        <property type="term" value="P:negative regulation of interleukin-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901223">
        <property type="term" value="P:negative regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045345">
        <property type="term" value="P:positive regulation of MHC class I biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08320">
        <property type="entry name" value="Pyrin_NALPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000707">
        <property type="entry name" value="NACHT, LRR and PYD domains-containing protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000064">
        <property type="entry name" value="NLR family pyrin domain containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000615">
        <property type="entry name" value="NLR family pyrin domain containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004020">
        <property type="entry name" value="DAPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF11">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02758">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM01289">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50824">
        <property type="entry name" value="DAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pyrin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="15">
        <location>
            <begin position="211"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007375.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120622" checksum="C1C06A83B9089A86" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LC39</accession>
    <name>A0A2I3LC39_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMEM208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM208 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003917027.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LC39"/>
    <dbReference type="STRING" id="9555.ENSPANP00000021019"/>
    <dbReference type="Ensembl" id="ENSPANT00000059376.2">
        <property type="protein sequence ID" value="ENSPANP00000021019.1"/>
        <property type="gene ID" value="ENSPANG00000029479.2"/>
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    <dbReference type="KEGG" id="panu:101010964"/>
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    <dbReference type="GeneTree" id="ENSGT00390000008139"/>
    <dbReference type="OMA" id="PIRAGWM"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
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        <property type="component" value="Chromosome 18"/>
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    <dbReference type="Bgee" id="ENSPANG00000029479">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="68"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="129"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="173"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000021019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="173" mass="19614" checksum="34C4E46D161067BE" modified="2018-02-28" version="1">MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVFFYSSASFWAWLALGFSLAVYGASYHSMSSMARAAFSEDGALMDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYVWSFWLLAPGRALYLLWVNVLGPWFTADSGTPAPEHNEKRQRRQERRQMKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LDS4</accession>
    <name>A0A2I3LDS4_PAPAN</name>
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        <submittedName>
            <fullName evidence="3">Storkhead box 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">STOX2</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003899401.5"/>
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        <property type="protein sequence ID" value="ENSPANP00000021597.2"/>
        <property type="gene ID" value="ENSPANG00000001074.3"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 63 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001893">
        <property type="term" value="P:maternal placenta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:response to bacterium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Storkhead-box_WHD"/>
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        <property type="entry name" value="STOX1/2"/>
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        <property type="entry name" value="STORKHEAD-BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WINGED HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10264">
        <property type="entry name" value="WHD_Storkhead"/>
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            <begin position="63"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="18"/>
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            <begin position="914"/>
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        <source>
            <dbReference type="Pfam" id="PF10264"/>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGJ4</accession>
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        <recommendedName>
            <fullName evidence="4">Filensin</fullName>
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        <alternativeName>
            <fullName evidence="17">Beaded filament structural protein 1</fullName>
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        <name evidence="23" type="primary">BFSP1</name>
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        <name type="scientific">Papio anubis</name>
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        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
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    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA. Identified in a complex that contains VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin. Found in a complex composed of PPL (via C-terminal linker domain), BFSP1 and BFSP2 in the retinal lens. Within the complex interacts with BFSP2. Interacts (via C-terminus) with MIP (via C-terminus) in aged lens fiber cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LGJ4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000022624"/>
    <dbReference type="Ensembl" id="ENSPANT00000040819.2">
        <property type="protein sequence ID" value="ENSPANP00000022624.2"/>
        <property type="gene ID" value="ENSPANG00000029429.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016976"/>
    <dbReference type="OMA" id="IQTTPRV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029429">
        <property type="expression patterns" value="Expressed in optic disc and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070307">
        <property type="term" value="P:lens fiber cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000094">
        <property type="entry name" value="Beaded filament structural protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000009">
        <property type="entry name" value="filensin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042358">
        <property type="entry name" value="BFSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14069">
        <property type="entry name" value="FILENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14069:SF0">
        <property type="entry name" value="FILENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="11" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="IF rod" evidence="22">
        <location>
            <begin position="40"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="508"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="44"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022624.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="665" mass="74357" checksum="75B8C24FC922DC9E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGL3</accession>
    <name>A0A2I3LGL3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LGL3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000022548"/>
    <dbReference type="Ensembl" id="ENSPANT00000031458.2">
        <property type="protein sequence ID" value="ENSPANP00000022548.2"/>
        <property type="gene ID" value="ENSPANG00000033056.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160305"/>
    <dbReference type="OMA" id="GWGSVQD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000033056">
        <property type="expression patterns" value="Expressed in amygdala and 48 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000039">
        <property type="entry name" value="Brain-specific serine protease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035277630" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="49"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="316" mass="33839" checksum="EB30B9BD4C851AE1" modified="2022-05-25" version="2">MVVSGPPSLGGGCLGTFTSLLLLAWTATLNAARIPVPPACGKPQQLNRVVGGEDSTDNEWPWVVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPSLFSVLLGAWQLGNPGSRSQKVGVAWVQPHPMYSWKEGARADIALVRLEHSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSRLYWRGAGHEAITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGSGALRAPSPGSGAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGZ9</accession>
    <name>A0A2I3LGZ9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM91</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LGZ9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000022774"/>
    <dbReference type="Ensembl" id="ENSPANT00000040326.2">
        <property type="protein sequence ID" value="ENSPANP00000022774.2"/>
        <property type="gene ID" value="ENSPANG00000009466.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183147"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009466">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LGZ9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14768:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14768">
        <property type="entry name" value="UPF0338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022774.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="189" mass="20717" checksum="116906410E9B5370" modified="2022-05-25" version="2">MRCGFAGGVGHQRKRTRRRLNPRDETQGSRPEEGDPEREDSEAGTQGNPSWSFPKAMDSPSLRELQQPLLESTECETPAQKPGRHELGSALREIAFAESLRGLQFLSPPLPSVSAGLGEPRPPDVEDMSSSDSDSDWDGSSRLSPFLPHDHLGLAVFSMLCCFWPVGIAAFCLAQKTRPSCPYSPHCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LHL1</accession>
    <name>A0A2I3LHL1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CLN8 transmembrane ER and ERGIC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLN8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_021798494.1">
        <property type="nucleotide sequence ID" value="XM_021942802.2"/>
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    <dbReference type="RefSeq" id="XP_031525201.1">
        <property type="nucleotide sequence ID" value="XM_031669341.1"/>
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    <dbReference type="RefSeq" id="XP_031525202.1">
        <property type="nucleotide sequence ID" value="XM_031669342.1"/>
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    <dbReference type="RefSeq" id="XP_031525203.1">
        <property type="nucleotide sequence ID" value="XM_031669343.1"/>
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    <dbReference type="Ensembl" id="ENSPANT00000038699.2">
        <property type="protein sequence ID" value="ENSPANP00000022926.2"/>
        <property type="gene ID" value="ENSPANG00000021588.3"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="P:regulation of cell size"/>
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        <property type="term" value="P:retina development in camera-type eye"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:somatic motor neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:visual perception"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="TLC-dom"/>
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        <property type="entry name" value="TLCD"/>
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    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF7">
        <property type="entry name" value="PROTEIN CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="42"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="62"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="286" mass="32774" checksum="AE3FAAA1897504E2" modified="2022-05-25" version="2">MNPVGDGGTSESIFDLDYASWGIRSTLMVAGFVFYLGVFVVCHQLSSSLNATYRSLVAREKVFWDLAATRAVFGVQSTTAGLWALLGDPVLHADRARGQQNWCWFHITTATGFFFFENVAVHLSNVAFRTFDLFLVVHHLFAFLGFLGCLVNLRAGHYLAMTTLLLEMSTPFTCISWMLLKAGWSESLFWKLNQWLMIHMFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLALFLVGLALLTLIINPYWTHKKTQQLLSPVDWNFAQPEAKSRPEGNGQLLQKKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LR60</accession>
    <name>A0A2I3LR60_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ELP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LR60"/>
    <dbReference type="Ensembl" id="ENSPANT00000045932.2">
        <property type="protein sequence ID" value="ENSPANP00000025943.1"/>
        <property type="gene ID" value="ENSPANG00000011823.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000916"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011823">
        <property type="expression patterns" value="Expressed in metanephros cortex and 64 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A2I3LR60">
        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:elongator holoenzyme complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative rna polymerase ii elongator complex subunit elp2 wd repeat superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
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    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
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    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="177"/>
            <end position="212"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="584"/>
            <end position="616"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="804" mass="90009" checksum="90F2F1FC51009676" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LT70</accession>
    <name>A0A2I3LT70_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 35 member F6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC35F6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role as a nucleotide-sugar transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with SLC25A5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908429.1">
        <property type="nucleotide sequence ID" value="XM_003908380.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LT70"/>
    <dbReference type="STRING" id="9555.ENSPANP00000026665"/>
    <dbReference type="Ensembl" id="ENSPANT00000057021.2">
        <property type="protein sequence ID" value="ENSPANP00000026665.1"/>
        <property type="gene ID" value="ENSPANG00000030429.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101019791"/>
    <dbReference type="KEGG" id="panu:101019791"/>
    <dbReference type="CTD" id="54978"/>
    <dbReference type="GeneTree" id="ENSGT00390000017237"/>
    <dbReference type="OMA" id="FIYKHNV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000030429">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014165762" description="Solute carrier family 35 member F6" evidence="10">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="371" mass="40339" checksum="1BBCBA0FD148EDC0" modified="2018-02-28" version="1">MAWTKYQLFLAGLMLVTGSINTLSAKWADNFVAEGCRGSKEHSFQHPFLQAVGMFLGEFSCLAAFYLLRCRATGQSDSSVDPQQPFNPLLFLPPALCDMTGTSLMYVALNMTSASSFQMLRGAVIIFTGLFSVAFLGRRLVLSQWLGILATIAGLVVVGLADLLSKHDSQHKLSEVITGDLLIIMAQIIVAIQMVLEEKFVYKHNVHPLRAVGTEGLFGFVILSLLLVPMYYIPAGSFSGNPRGTLEDALDAFCQVGRQPLIAVALLGNISSIAFFNFAGISVTKELSATTRMVLDSLRTVVIWALSLALGWEAFHALQILGFLILLIGTALYNGLHRPLLGRLSRGRPLAEESEQERLLGGTRTPINDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LVT8</accession>
    <name>A0A2I3LVT8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule associated tyrosine carboxypeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MATCAP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LVT8"/>
    <dbReference type="SMR" id="A0A2I3LVT8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000027553"/>
    <dbReference type="Ensembl" id="ENSPANT00000055333.2">
        <property type="protein sequence ID" value="ENSPANP00000027553.2"/>
        <property type="gene ID" value="ENSPANG00000035304.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004417"/>
    <dbReference type="OMA" id="RILQPPW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106423">
        <property type="term" value="F:tubulin-tyrosine carboxypeptidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="MATCAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817:SF1">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED TYROSINE CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
        <property type="entry name" value="MATCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01154">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="471" mass="53387" checksum="2CA596E126A1347D" modified="2022-05-25" version="2">MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPEPEQQPFSQMHLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGQNPGGGTLRPAASLPHIAKTQRDAGHSASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCVGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLARYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M376</accession>
    <name>A0A2I3M376_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL30</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021779895.1">
        <property type="nucleotide sequence ID" value="XM_021924203.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021779896.1">
        <property type="nucleotide sequence ID" value="XM_021924204.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M376"/>
    <dbReference type="STRING" id="9555.ENSPANP00000030170"/>
    <dbReference type="Ensembl" id="ENSPANT00000038832.2">
        <property type="protein sequence ID" value="ENSPANP00000030170.1"/>
        <property type="gene ID" value="ENSPANG00000008194.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000200"/>
    <dbReference type="CTD" id="377007"/>
    <dbReference type="GeneTree" id="ENSGT00940000158597"/>
    <dbReference type="OMA" id="WFYSGVC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008194">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M376">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd18469">
        <property type="entry name" value="BACK_KLHL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030582">
        <property type="entry name" value="KLHL30_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000030170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="578" mass="64202" checksum="13EF9C849AB6A497" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M6X4</accession>
    <name>A0A2I3M6X4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor-binding cancer antigen expressed on SiSo cells</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EBAG9</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3M6X4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031399"/>
    <dbReference type="Ensembl" id="ENSPANT00000035115.2">
        <property type="protein sequence ID" value="ENSPANP00000031399.1"/>
        <property type="gene ID" value="ENSPANG00000015083.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004040"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015083">
        <property type="expression patterns" value="Expressed in pancreas and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M6X4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090717">
        <property type="term" value="P:adaptive immune memory response involving T cells and B cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001913">
        <property type="term" value="P:T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017025">
        <property type="entry name" value="Cancer-assoc_antigen_RCAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208:SF2">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034247">
        <property type="entry name" value="RCAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="1" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014156164" description="Receptor-binding cancer antigen expressed on SiSo cells" evidence="3">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR034247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="258" mass="29342" checksum="43BB84FA2C9EAF82" modified="2018-02-28" version="1">MAITQFRLFKFCTCLATVFSFLKRLICRSGRGRKLSGDQITLPTTVDYSSVPKQTDVEEWTSWDEDAPTSVKIEGGNGSVATQQNSLEQLEPDYFKDMTPTIRKTQKIVIKKREPLNFGIPDGSTGFSSRLAATQDLPFIHQSSELGDLDTWQENTNAWEEEEDAAWQAEEVLRSRTNVCSLCSVLFHHPTPTSTPYINQSIKIERVSLGQWSYGKSKEGQKLADREKRAAEQQRKKMEKEAQRLMKKEQNKIGVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M702</accession>
    <name>A0A2I3M702_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="12">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EIF2A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003895004.2">
        <property type="nucleotide sequence ID" value="XM_003894955.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M702"/>
    <dbReference type="STRING" id="9555.ENSPANP00000031433"/>
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        <property type="protein sequence ID" value="ENSPANP00000031433.2"/>
        <property type="gene ID" value="ENSPANG00000017829.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022621"/>
    <dbReference type="KEGG" id="panu:101022621"/>
    <dbReference type="CTD" id="83939"/>
    <dbReference type="GeneTree" id="ENSGT00730000111053"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017829">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M702">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000359">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000407">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="14">
        <location>
            <begin position="216"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="432"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031433.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="585" mass="65023" checksum="ABC58415E1AF3F34" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MA56</accession>
    <name>A0A2I3MA56_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein phosphatase non-receptor type</fullName>
            <ecNumber evidence="11">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PTPN3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May act at junctions between the membrane and the cytoskeleton.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3MA56"/>
    <dbReference type="Ensembl" id="ENSPANT00000054389.2">
        <property type="protein sequence ID" value="ENSPANP00000032529.2"/>
        <property type="gene ID" value="ENSPANG00000025736.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157888"/>
    <dbReference type="HOGENOM" id="CLU_001645_7_0_1"/>
    <dbReference type="OMA" id="GIFHIRC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098902">
        <property type="term" value="P:regulation of membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902305">
        <property type="term" value="P:regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13189">
        <property type="entry name" value="FERM_C_PTPN4_PTPN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17193">
        <property type="entry name" value="FERM_F1_PTPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06706">
        <property type="entry name" value="PDZ_PTPN3-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14600">
        <property type="entry name" value="PTPc-N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000104">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000023">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041783">
        <property type="entry name" value="PTPN3/4_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012151">
        <property type="entry name" value="Tyr_Pase_non-rcpt_typ-3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000927">
        <property type="entry name" value="Tyr-Ptase_nr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="17">
        <location>
            <begin position="141"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="18">
        <location>
            <begin position="622"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="758"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="931"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="12">
        <location>
            <position position="954"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="923"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="954"/>
            <end position="960"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="998"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032529.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115611" checksum="1F70D3F9E93E1ED0" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MIM6</accession>
    <name>A0A2I3MIM6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNG8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_017808039.1">
        <property type="nucleotide sequence ID" value="XM_017952550.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MIM6"/>
    <dbReference type="SMR" id="A0A2I3MIM6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000035579"/>
    <dbReference type="Ensembl" id="ENSPANT00000038923.2">
        <property type="protein sequence ID" value="ENSPANP00000035579.1"/>
        <property type="gene ID" value="ENSPANG00000029260.2"/>
    </dbReference>
    <dbReference type="GeneID" id="108583299"/>
    <dbReference type="KEGG" id="panu:108583299"/>
    <dbReference type="CTD" id="94235"/>
    <dbReference type="GeneTree" id="ENSGT01100000263497"/>
    <dbReference type="OMA" id="NIERMMI"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000029260">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:G-protein beta-subunit binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043584">
        <property type="term" value="P:nose development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="70" mass="7841" checksum="153205CC7F38EE40" modified="2018-02-28" version="1">MSNNMAKIAEARKTVEQLKLEVNIDRMKVSQAAAELLAFCETHAKDDPLVTPVPAAENPFRDKRLFCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MIN6</accession>
    <name>A0A2I3MIN6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase activating protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARHGAP25</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021780590.2">
        <property type="nucleotide sequence ID" value="XM_021924898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MIN6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000035598"/>
    <dbReference type="Ensembl" id="ENSPANT00000035736.2">
        <property type="protein sequence ID" value="ENSPANP00000035598.2"/>
        <property type="gene ID" value="ENSPANG00000010754.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101015525"/>
    <dbReference type="KEGG" id="panu:101015525"/>
    <dbReference type="CTD" id="9938"/>
    <dbReference type="GeneTree" id="ENSGT00950000183015"/>
    <dbReference type="OMA" id="HRASTYD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010754">
        <property type="expression patterns" value="Expressed in spleen and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MIN6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051058">
        <property type="term" value="P:negative regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13263">
        <property type="entry name" value="PH_RhoGap25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04390">
        <property type="entry name" value="RhoGAP_ARHGAP22_24_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000120">
        <property type="entry name" value="rho GTPase-activating protein 22 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000015">
        <property type="entry name" value="rho GTPase-activating protein 25 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF20">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="46"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="160"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035598.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="646" mass="73567" checksum="643AE451C4DCDB95" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MRS6</accession>
    <name>A0A2I3MRS6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclic AMP-dependent transcription factor ATF-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATF7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MRS6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000038444"/>
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        <property type="protein sequence ID" value="ENSPANP00000038444.2"/>
        <property type="gene ID" value="ENSPANG00000013986.3"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
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    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="TF_CRE-BP1-typ"/>
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        <property type="entry name" value="ATF2_CRE-BP1"/>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
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            <begin position="349"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="424"/>
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    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="374"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="131"/>
            <end position="143"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="500" mass="54097" checksum="388AE703679B926C" modified="2022-05-25" version="2">MKILLLDFIAFFPPIFLFLLFFFQKVMIFHLSFLVSVPPNKIAPLCYMKYGRRQTVCVQCPGLWTDQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKAAAGPLDMSLPSTPDIKIKEEEPVEVDSSPPDSPSSSPCSPPLKEKEVAPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPTNGLSVRSAAEAVATSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N5D4</accession>
    <name>A0A2I3N5D4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcyclin-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009212334.1">
        <property type="nucleotide sequence ID" value="XM_009214070.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508325.1">
        <property type="nucleotide sequence ID" value="XM_031652465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508326.1">
        <property type="nucleotide sequence ID" value="XM_031652466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N5D4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000043209"/>
    <dbReference type="Ensembl" id="ENSPANT00000020237.3">
        <property type="protein sequence ID" value="ENSPANP00000043209.1"/>
        <property type="gene ID" value="ENSPANG00000000973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021284"/>
    <dbReference type="GeneID" id="116269493"/>
    <dbReference type="GeneID" id="116269494"/>
    <dbReference type="KEGG" id="panu:101021284"/>
    <dbReference type="KEGG" id="panu:116269493"/>
    <dbReference type="KEGG" id="panu:116269494"/>
    <dbReference type="GeneTree" id="ENSGT00390000016470"/>
    <dbReference type="OMA" id="KNTRWDY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000973">
        <property type="expression patterns" value="Expressed in metanephros cortex and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000006">
        <property type="entry name" value="calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000006">
        <property type="entry name" value="calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037201">
        <property type="entry name" value="CacyBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015120">
        <property type="entry name" value="Siah-Interact_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09032">
        <property type="entry name" value="Siah-Interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140106">
        <property type="entry name" value="Calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CS" evidence="12">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="11">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="228" mass="26227" checksum="42BF4313E95D5ADB" modified="2018-02-28" version="1">MASEELQKDLEEVKVLLEKGTRKRVRDALMAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYKVKSSNYGWDQSDKFVKIYTTLSGVHQVPTENVQVHFTERSFDVLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMHVLKKIYEDGDDDMKRTIDKAWVESREKQSKGDTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N8H4</accession>
    <name>A0A2I3N8H4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Inhibitor of nuclear factor kappa-B kinase subunit beta</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
            <ecNumber evidence="4">2.7.11.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">I-kappa-B kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Nuclear factor NF-kappa-B inhibitor kinase beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Serine/threonine protein kinase IKBKB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">IKBKB</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EC" id="2.7.11.10" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3N8H4"/>
    <dbReference type="Ensembl" id="ENSPANT00000035501.2">
        <property type="protein sequence ID" value="ENSPANP00000044320.1"/>
        <property type="gene ID" value="ENSPANG00000013874.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182937"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013874">
        <property type="expression patterns" value="Expressed in cornea and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N8H4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008385">
        <property type="term" value="C:IkappaB kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990459">
        <property type="term" value="F:transferrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002221">
        <property type="term" value="P:pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14038">
        <property type="entry name" value="STKc_IKK_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17046">
        <property type="entry name" value="Ubl_IKKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000087">
        <property type="entry name" value="Inhibitor of nuclear factor kappa B kinase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000147">
        <property type="entry name" value="Inhibitor of nuclear factor kappa-B kinase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.250:FF:000002">
        <property type="entry name" value="Putative inhibitor of nuclear factor kappa-B kinase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041185">
        <property type="entry name" value="IKBKB_SDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046375">
        <property type="entry name" value="IKBKB_SDD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022007">
        <property type="entry name" value="IKKbetaNEMObind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF7">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18397">
        <property type="entry name" value="IKBKB_SDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12179">
        <property type="entry name" value="IKKbetaNEMObind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01239">
        <property type="entry name" value="IKKbetaNEMObind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="28">
        <location>
            <begin position="305"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="665"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="26">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00072641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00075315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="754" mass="86013" checksum="A06F0D2B2FFB0986" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NAC2</accession>
    <name>A0A2I3NAC2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 20">Splicing factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SF1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009183981.1">
        <property type="nucleotide sequence ID" value="XM_009185717.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NAC2"/>
    <dbReference type="SMR" id="A0A2I3NAC2"/>
    <dbReference type="Ensembl" id="ENSPANT00000049519.2">
        <property type="protein sequence ID" value="ENSPANP00000044822.2"/>
        <property type="gene ID" value="ENSPANG00000020754.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137600"/>
    <dbReference type="CTD" id="7536"/>
    <dbReference type="GeneTree" id="ENSGT00940000157258"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020754">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NAC2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22382">
        <property type="entry name" value="KH-I_SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative splicing factor 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
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    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
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    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
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    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 20" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 20" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="22">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="65"/>
            <end position="94"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="325"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="470"/>
            <end position="499"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="567"/>
            <end position="591"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="598"/>
            <end position="608"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="615"/>
            <end position="625"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044822.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="639" mass="68330" checksum="EEBC6A02B29DAE4D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NB48</accession>
    <name>A0A2I3NB48_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium binding domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EFCAB2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003893674.5"/>
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        <property type="gene ID" value="ENSPANG00000026471.3"/>
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    <dbReference type="KEGG" id="panu:101017783"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160590"/>
    <dbReference type="OMA" id="MTKEGEP"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026471">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NB48">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="162" mass="18924" checksum="13E1B6BD5F7503F7" modified="2018-02-28" version="1">MADEKDREEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERRYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEGEPFSQEEMEEMLSAAIDPESNSIHYKDYITMMVIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NBD7</accession>
    <name>A0A2I3NBD7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="4" type="primary">GGCT</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3NBD7"/>
    <dbReference type="Ensembl" id="ENSPANT00000039662.2">
        <property type="protein sequence ID" value="ENSPANP00000045168.1"/>
        <property type="gene ID" value="ENSPANG00000019769.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044921"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019769">
        <property type="expression patterns" value="Expressed in zone of skin and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NBD7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000045168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="114" mass="12939" checksum="40602FBC20DB2A26" modified="2018-02-28" version="1">MANSGCKDVPGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDELFAWVQKKMVCRWSIKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NFJ3</accession>
    <name>A0A2I3NFJ3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DNASE1L3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894301.1">
        <property type="nucleotide sequence ID" value="XM_003894252.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NFJ3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000046752"/>
    <dbReference type="Ensembl" id="ENSPANT00000041533.2">
        <property type="protein sequence ID" value="ENSPANP00000046752.1"/>
        <property type="gene ID" value="ENSPANG00000008562.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014115"/>
    <dbReference type="KEGG" id="panu:101014115"/>
    <dbReference type="CTD" id="1776"/>
    <dbReference type="GeneTree" id="ENSGT00950000182846"/>
    <dbReference type="OMA" id="ESIARCD"/>
    <dbReference type="OrthoDB" id="10061407at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008562">
        <property type="expression patterns" value="Expressed in spleen and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NFJ3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002283">
        <property type="term" value="P:neutrophil activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010623">
        <property type="term" value="P:programmed cell death involved in cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002673">
        <property type="term" value="P:regulation of acute inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070948">
        <property type="term" value="P:regulation of neutrophil mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10282">
        <property type="entry name" value="DNase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000007">
        <property type="entry name" value="Deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018057">
        <property type="entry name" value="Deoxyribonuclease-1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033125">
        <property type="entry name" value="DNASE_I_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371">
        <property type="entry name" value="DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371:SF32">
        <property type="entry name" value="DEOXYRIBONUCLEASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000988">
        <property type="entry name" value="DNase_I_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00130">
        <property type="entry name" value="DNASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00919">
        <property type="entry name" value="DNASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00918">
        <property type="entry name" value="DNASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014113114" description="Deoxyribonuclease" evidence="10">
        <location>
            <begin position="21"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Essential for enzymatic activity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="305" mass="35511" checksum="142BEA486872BA16" modified="2018-02-28" version="1">MSQELAPLLLLLLSIHSALALRICSFNVRSFGESKQEDQNAMDVIVKVIKRCDIMLLMEIKDSNNRICPVLMEKLNGNSRRGIMYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYHDYQDGDVDVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVDVYMDMKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKRSTKCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTVRKKTKSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MVB8</accession>
    <name>A0A8I5MVB8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcl-2-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Apoptosis regulator Bcl-X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BCL2L1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Isoform Bcl-X(S) promotes apoptosis.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Forms heterodimers with BAX, BAK or BCL2; heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with isoform 1 of SIVA1; the interaction inhibits the anti-apoptotic activity. Interacts with IKZF3. Interacts with RTL10/BOP. Interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV. Interacts with BECN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle</location>
            <location evidence="4">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904949.2">
        <property type="nucleotide sequence ID" value="XM_003904900.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214640.2">
        <property type="nucleotide sequence ID" value="XM_009216376.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214641.2">
        <property type="nucleotide sequence ID" value="XM_009216377.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214642.2">
        <property type="nucleotide sequence ID" value="XM_009216378.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214643.2">
        <property type="nucleotide sequence ID" value="XM_009216379.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214644.2">
        <property type="nucleotide sequence ID" value="XM_009216380.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214645.2">
        <property type="nucleotide sequence ID" value="XM_009216381.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214646.2">
        <property type="nucleotide sequence ID" value="XM_009216382.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009214647.2">
        <property type="nucleotide sequence ID" value="XM_009216383.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MVB8"/>
    <dbReference type="SMR" id="A0A8I5MVB8"/>
    <dbReference type="Ensembl" id="ENSPANT00000080454.1">
        <property type="protein sequence ID" value="ENSPANP00000048621.1"/>
        <property type="gene ID" value="ENSPANG00000037352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101019436"/>
    <dbReference type="KEGG" id="panu:101019436"/>
    <dbReference type="CTD" id="598"/>
    <dbReference type="GeneTree" id="ENSGT01130000278332"/>
    <dbReference type="OMA" id="HAPTSHI"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097136">
        <property type="term" value="C:Bcl-2 family protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051434">
        <property type="term" value="F:BH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071839">
        <property type="term" value="P:apoptotic process in bone marrow cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071312">
        <property type="term" value="P:cellular response to alkaloid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071480">
        <property type="term" value="P:cellular response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097048">
        <property type="term" value="P:dendritic cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044565">
        <property type="term" value="P:dendritic cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035234">
        <property type="term" value="P:ectopic germ cell programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097284">
        <property type="term" value="P:hepatocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000669">
        <property type="term" value="P:negative regulation of dendritic cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902236">
        <property type="term" value="P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900118">
        <property type="term" value="P:negative regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902230">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903077">
        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000242">
        <property type="term" value="P:negative regulation of reproductive process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032946">
        <property type="term" value="P:positive regulation of mononuclear cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046902">
        <property type="term" value="P:regulation of mitochondrial membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046898">
        <property type="term" value="P:response to cycloheximide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000003">
        <property type="entry name" value="Bcl-2-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013279">
        <property type="entry name" value="Apop_reg_BclX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004725">
        <property type="entry name" value="Bcl2/BclX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020717">
        <property type="entry name" value="Bcl2_BH1_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020728">
        <property type="entry name" value="Bcl2_BH3_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003093">
        <property type="entry name" value="Bcl2_BH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020731">
        <property type="entry name" value="Bcl2_BH4_motif_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00865">
        <property type="entry name" value="bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF12">
        <property type="entry name" value="BCL-2-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02180">
        <property type="entry name" value="BH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01864">
        <property type="entry name" value="APOPREGBCLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00265">
        <property type="entry name" value="BH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01080">
        <property type="entry name" value="BH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01259">
        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01260">
        <property type="entry name" value="BH4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50063">
        <property type="entry name" value="BH4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis regulator Bcl-2 family BH4" evidence="27">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="BH4" evidence="24">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00056530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00062916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="233" mass="26077" checksum="986CFE94B8A6B4C1" modified="2022-05-25" version="1">MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLVDSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1A5</accession>
    <name>A0A8I5N1A5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GALNT14</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_021780408.1">
        <property type="nucleotide sequence ID" value="XM_021924716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N1A5"/>
    <dbReference type="Ensembl" id="ENSPANT00000077748.1">
        <property type="protein sequence ID" value="ENSPANP00000052728.1"/>
        <property type="gene ID" value="ENSPANG00000005616.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023442"/>
    <dbReference type="CTD" id="79623"/>
    <dbReference type="GeneTree" id="ENSGT00940000158182"/>
    <dbReference type="OMA" id="VAQEWTY"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000036">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF8">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="20">
        <location>
            <begin position="420"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="552" mass="64351" checksum="39524EF516ECBF46" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N271</accession>
    <name>A0A8I5N271_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N271"/>
    <dbReference type="Ensembl" id="ENSPANT00000068083.1">
        <property type="protein sequence ID" value="ENSPANP00000050149.1"/>
        <property type="gene ID" value="ENSPANG00000040201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="THTELSC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="990" mass="115722" checksum="7706BD92779E6968" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N6B2</accession>
    <name>A0A8I5N6B2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase</fullName>
            <ecNumber evidence="13">2.4.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-galactoside alpha-2,3-sialyltransferase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">N-acetyllactosaminide alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">ST3Gal III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">ST3N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Sialyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ST3GAL3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52316"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="EC" id="2.4.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.6" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N6B2"/>
    <dbReference type="Ensembl" id="ENSPANT00000069631.1">
        <property type="protein sequence ID" value="ENSPANP00000056263.1"/>
        <property type="gene ID" value="ENSPANG00000023558.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157285"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008118">
        <property type="term" value="F:N-acetyllactosaminide alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000003">
        <property type="entry name" value="CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF37">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-1,4-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="448" mass="49871" checksum="C575EF3CAC440EAC" modified="2022-05-25" version="1">MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQALGSEYDRLGFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVFKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPHVKNLNSLPHFRFGHQPSTDPSLKPGNLGPALQQLLCCYIWVMGGCWREPPICADSYFCKSGGSGLSPHSCLSVFLPILHHPPPLFQSLPCPKSSSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N771</accession>
    <name>A0A8I5N771_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tenascin-N</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Tenascin-W</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TNN</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1. Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tenascin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_017957749.3"/>
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        <property type="protein sequence ID" value="ENSPANP00000053152.1"/>
        <property type="gene ID" value="ENSPANG00000005095.3"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:CA3 pyramidal cell dendrite"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1990026">
        <property type="term" value="C:hippocampal mossy fiber expansion"/>
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    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
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        <property type="term" value="C:perisynaptic extracellular matrix"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:tenascin complex"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="term" value="F:integrin binding"/>
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        <property type="term" value="P:axonogenesis"/>
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        <property type="term" value="P:cell-matrix adhesion"/>
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        <property type="term" value="P:positive regulation of neuron projection development"/>
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        <property type="term" value="P:positive regulation of sprouting angiogenesis"/>
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        <property type="term" value="P:regulation of bone development"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905899">
        <property type="term" value="P:regulation of smooth muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000332">
        <property type="entry name" value="Tenascin N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000156">
        <property type="entry name" value="Tenascin N"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000534">
        <property type="entry name" value="Tenascin N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000783">
        <property type="entry name" value="Tenascin N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF12">
        <property type="entry name" value="TENASCIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
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    <dbReference type="SMART" id="SM00181">
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        <property type="match status" value="3"/>
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        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
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    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FIBRINOGEN_C_2"/>
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    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035181058" description="Tenascin-N" evidence="15">
        <location>
            <begin position="27"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="264"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="354"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="445"/>
            <end position="532"/>
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    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="533"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="624"/>
            <end position="709"/>
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    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="710"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="801"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="887"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="977"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="17">
        <location>
            <begin position="1061"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="957"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="958"/>
            <end position="977"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008673"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072694"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080295"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144074" checksum="45C0E50C5235269B" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N823</accession>
    <name>A0A8I5N823_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N823"/>
    <dbReference type="Ensembl" id="ENSPANT00000079276.1">
        <property type="protein sequence ID" value="ENSPANP00000052486.1"/>
        <property type="gene ID" value="ENSPANG00000049552.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182805"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF12">
        <property type="entry name" value="ALPHA-ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="15">
        <location>
            <begin position="142"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="434" mass="47286" checksum="7F49E9AE0C29CB88" modified="2022-05-25" version="1">MSILKVHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPMVSIEDPFDQDDWGAWQKFTASAGIQVVRDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8D9</accession>
    <name>A0A8I5N8D9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger AN1-type containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZFAND5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003911853.1">
        <property type="nucleotide sequence ID" value="XM_003911804.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003911854.1">
        <property type="nucleotide sequence ID" value="XM_003911805.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8D9"/>
    <dbReference type="SMR" id="A0A8I5N8D9"/>
    <dbReference type="Ensembl" id="ENSPANT00000061530.1">
        <property type="protein sequence ID" value="ENSPANP00000053788.1"/>
        <property type="gene ID" value="ENSPANG00000045942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101006725"/>
    <dbReference type="KEGG" id="panu:101006725"/>
    <dbReference type="CTD" id="7763"/>
    <dbReference type="GeneTree" id="ENSGT00940000156165"/>
    <dbReference type="OMA" id="VLCENNC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048745">
        <property type="term" value="P:smooth muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4770:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF26">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="213" mass="23132" checksum="E477504B1BA77753" modified="2022-05-25" version="1">MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADTSLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8P1</accession>
    <name>A0A8I5N8P1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">B-cell lymphoma/leukemia 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">B-cell CLL/lymphoma 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Homomultimer; homooligomerized following recruitment by CARD domain-containing proteins that form a nucleating helical template that recruits BCL10 via CARD-CARD interaction. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex. Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10-MALT1) complex. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDAH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N8P1"/>
    <dbReference type="Ensembl" id="ENSPANT00000069488.1">
        <property type="protein sequence ID" value="ENSPANP00000057559.1"/>
        <property type="gene ID" value="ENSPANG00000016437.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043442"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032449">
        <property type="term" value="C:CBM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019209">
        <property type="term" value="F:kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08810">
        <property type="entry name" value="CARD_BCL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000022">
        <property type="entry name" value="B-cell lymphoma/leukemia 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000004">
        <property type="entry name" value="N(G),N(G)-dimethylarginine dimethylaminohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033238">
        <property type="entry name" value="BCL10/E10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042143">
        <property type="entry name" value="CARD_BCL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34920">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34920:SF1">
        <property type="entry name" value="B-CELL LYMPHOMA_LEUKEMIA 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19420">
        <property type="entry name" value="DDAH_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CARD" evidence="18">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="435" mass="47400" checksum="B0918D5DAD07EABA" modified="2022-05-25" version="1">MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSSESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCGNSKTGFCHVVQAGLELLGSRNLPSLASQSPGITDLSHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N9L2</accession>
    <name>A0A8I5N9L2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial peptide methionine sulfoxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N9L2"/>
    <dbReference type="Ensembl" id="ENSPANT00000069896.1">
        <property type="protein sequence ID" value="ENSPANP00000056609.1"/>
        <property type="gene ID" value="ENSPANG00000016252.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003823"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000001">
        <property type="entry name" value="Peptide methionine sulfoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000073">
        <property type="entry name" value="Trypsin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035292241" description="Mitochondrial peptide methionine sulfoxide reductase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="248"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="479" mass="53256" checksum="D46CA9975CB47259" modified="2022-05-25" version="1">MLSATRRACQLLLLHSLFPVPRMGNSASSIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHISFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKEDYQKVLSEHGFGPITTDIREGQIFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPMECGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARGEPFCGGSILNKWWILTAAHCLYSEELFPEELNVVLGTNDLTSSSMEIKEVASIILHKDFKRANMDNDIALLLLASPITLDDLKVPICLPTQHGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKAFPKLTKNMLCAGYNNESYDACQSCLIHSTPPPMLYNPTTSRANLAATRFSRGAGMVWVKVSIDEMSFGSQSWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NA02</accession>
    <name>A0A8I5NA02_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C1orf202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NA02"/>
    <dbReference type="Ensembl" id="ENSPANT00000053205.2">
        <property type="protein sequence ID" value="ENSPANP00000049903.1"/>
        <property type="gene ID" value="ENSPANG00000032745.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000147125"/>
    <dbReference type="OMA" id="CWCWRRL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="183" mass="20504" checksum="99D107AE5C49ED3D" modified="2022-05-25" version="1">MAAPRLGGPRRGGAQHELLEEAARLKRGPAPRGEPEAVGRRVVAGDGGSCSGCWCWRRLFRSPRRKKLRQAHARSGKAAPERGLWGPSSLQRLLQRLATWRRRYLRCKERPDRLEEIPLLVLDRAQGAHEAAARPQSSAPGRPEQAAPARQPRRRAATRSRPPFAPPVHAQHCFFFLVNKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NB72</accession>
    <name>A0A8I5NB72_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NB72"/>
    <dbReference type="Ensembl" id="ENSPANT00000069957.1">
        <property type="protein sequence ID" value="ENSPANP00000053987.1"/>
        <property type="gene ID" value="ENSPANG00000039656.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286925"/>
    <dbReference type="OMA" id="NICTAMF"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="833" mass="97430" checksum="EF9FDF7278242CF6" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NE61</accession>
    <name>A0A8I5NE61_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NE61"/>
    <dbReference type="Ensembl" id="ENSPANT00000060802.1">
        <property type="protein sequence ID" value="ENSPANP00000056848.1"/>
        <property type="gene ID" value="ENSPANG00000037634.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035251497" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8533" checksum="AC6FF8B635C28720" modified="2022-05-25" version="1">MLKCSHKGFFPFFFFFFFEIESQSVAQAGVQWRILGSLQALPPRFMLFSCLSLPNSWDYRRPPPRPANFSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NEW4</accession>
    <name>A0A8I5NEW4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NEW4"/>
    <dbReference type="Ensembl" id="ENSPANT00000073348.1">
        <property type="protein sequence ID" value="ENSPANP00000052702.1"/>
        <property type="gene ID" value="ENSPANG00000039118.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286923"/>
    <dbReference type="OMA" id="MDQCAAL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="39"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="289" mass="32252" checksum="B5C90954D970AB79" modified="2022-05-25" version="1">MEMRNTTSDFILLGLFNHSTAHQVLFMMLLAIVLTSLFGNALMILLIHRDRRLHTPMYFLLSQLSLMDMMLVSTTVPKMAADYLTGNKAISRAGCGAQIFFLPTLGGGECFLLAAVAYDRCAAVCHPLRYPMLMSWQLCLRMTMSCWLLGAADGLLQAAASLSFPYCGAHEIDHFFCEAPVLVRLACADTSVFENAMYISRKKAFATCSSHVAVVGLFYGAAIFTYLRPKSHRSTNHDKVVSAFYTVFTPLLNPLIYSVRNSEVKGALKWWLGTCVNIKHQQNEAHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLV7</accession>
    <name>A0A8I5NLV7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Espin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ESPNL</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with MYO3A (via C-terminus). Interacts with MYO3B (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Stereocilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003908198.3">
        <property type="nucleotide sequence ID" value="XM_003908149.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLV7"/>
    <dbReference type="Ensembl" id="ENSPANT00000077713.1">
        <property type="protein sequence ID" value="ENSPANP00000061126.1"/>
        <property type="gene ID" value="ENSPANG00000043372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100997737"/>
    <dbReference type="KEGG" id="panu:100997737"/>
    <dbReference type="CTD" id="339768"/>
    <dbReference type="GeneTree" id="ENSGT00940000156970"/>
    <dbReference type="OMA" id="NGQLECC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000268">
        <property type="entry name" value="Espin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000295">
        <property type="entry name" value="Espin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000255">
        <property type="entry name" value="espin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF0">
        <property type="entry name" value="ESPIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1009">Hearing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="333"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1005" mass="107945" checksum="ABE98D9021F16A60" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMU7</accession>
    <name>A0A8I5NMU7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NMU7"/>
    <dbReference type="Ensembl" id="ENSPANT00000069618.1">
        <property type="protein sequence ID" value="ENSPANP00000054549.1"/>
        <property type="gene ID" value="ENSPANG00000042816.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164694"/>
    <dbReference type="OMA" id="EPKCEKG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="330" mass="36174" checksum="A9532159676EAEBE" modified="2022-05-25" version="1">MSSYRRLILFHYSLADVNECTIDNGGCQDRCCNTVGSYYCKCQADQKLEEDGKGCEDVDECAVVNGGCQQRCINTLGTFHWECDTGWRLHADECTCIKMDPCTGGNGCVHICQSENGTARCACHAGYRLSEDKNICEDINECAEGLSYGGHHCVNSMGSFTCACHTGFELGADRKQCYRIELGIVNSCEKNNGGCSHHHEHAIGTPRCSCNHGHQLDSDEKMCIDLDECENGEACCDQLCISYLGGYECRCQESFQISSDGCGCDVCPDGLWGPECWFSSAPCENGGQCNNNNNEKLEIVTALLVTQENPVPYDTQKARIVHIAKRCVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NPH4</accession>
    <name>A0A8I5NPH4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zic family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZIC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NPH4"/>
    <dbReference type="Ensembl" id="ENSPANT00000079612.1">
        <property type="protein sequence ID" value="ENSPANP00000050883.1"/>
        <property type="gene ID" value="ENSPANG00000038628.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160645"/>
    <dbReference type="OMA" id="GQYGPMN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000035">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001330">
        <property type="entry name" value="Zinc finger protein ZIC 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="539" mass="56015" checksum="86B3B5BBDCD972FF" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NRR2</accession>
    <name>A0A8I5NRR2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ephrin-B3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">EFNB3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with GRIP1 and GRIP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912324.1">
        <property type="nucleotide sequence ID" value="XM_003912275.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NRR2"/>
    <dbReference type="Ensembl" id="ENSPANT00000082839.1">
        <property type="protein sequence ID" value="ENSPANP00000053750.1"/>
        <property type="gene ID" value="ENSPANG00000049483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101007398"/>
    <dbReference type="KEGG" id="panu:101007398"/>
    <dbReference type="CTD" id="1949"/>
    <dbReference type="GeneTree" id="ENSGT00940000160323"/>
    <dbReference type="OMA" id="HNALSAC"/>
    <dbReference type="OrthoDB" id="6250301at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016198">
        <property type="term" value="P:axon choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050771">
        <property type="term" value="P:negative regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099557">
        <property type="term" value="P:trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000019">
        <property type="entry name" value="Putative ephrin-B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019765">
        <property type="entry name" value="Ephrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF34">
        <property type="entry name" value="EPHRIN-B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01299">
        <property type="entry name" value="EPHRIN_RBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035207158" description="Ephrin-B3" evidence="20">
        <location>
            <begin position="28"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="21">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="168"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="340" mass="35885" checksum="8ED96973BE0EC6A4" modified="2022-05-25" version="1">MGPPHFGPGGVRVGALLLLGVLGLVSGLSLEPVYWNSANKRFQAEGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLLTCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRVGQSPRGGAAPRKPVSEMPMERDRGAAHSLEPGKENMPGDPTSNATSRGAEGPLPPPSMPAVAGAAGGLALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLGLGGGGGMGPREAEPGELGIALRGGGAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPPNIYYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NXE4</accession>
    <name>A0A8I5NXE4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRPS30</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NXE4"/>
    <dbReference type="Ensembl" id="ENSPANT00000068765.1">
        <property type="protein sequence ID" value="ENSPANP00000060967.1"/>
        <property type="gene ID" value="ENSPANG00000043307.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001442"/>
    <dbReference type="OMA" id="VNMPRYY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010793">
        <property type="entry name" value="Ribosomal_mL37/mL65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039982">
        <property type="entry name" value="Ribosomal_mL65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07147">
        <property type="entry name" value="PDCD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035178193" evidence="5">
        <location>
            <begin position="18"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="435" mass="49916" checksum="0F35F772491990B7" modified="2022-05-25" version="1">MAAARWWRPMLRGPSLSLHTAANAAATATETTCQDVAATPVARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQFMKYMVYPQTFALNADRWYQYFTKTVFLSGLPPTPAEPEPEPEPALDLAALRAVACDCLLQEHFYLRRKRRVHRYEESEVISLPFLDQLVATLVGLLSPHNPALAAAALDYRRPVHFYWVRGEEIIPRGHRKGRIDDLRYQIDDKPNNQVRISKQLAEFVPLDYSVPIEIPTIKCKPDKLPLFKRQYENRIFVGSKTADPCCYGHTQFHLLPNKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYETIEDNDVKGFNDDVLLQIVHFLLNRPKEEKAQLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NZQ0</accession>
    <name>A0A8I5NZQ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">H2BC17</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NZQ0"/>
    <dbReference type="SMR" id="A0A8I5NZQ0"/>
    <dbReference type="Ensembl" id="ENSPANT00000062430.1">
        <property type="protein sequence ID" value="ENSPANP00000056850.1"/>
        <property type="gene ID" value="ENSPANG00000047669.1"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101021342"/>
    <dbReference type="GeneTree" id="ENSGT01150000286984"/>
    <dbReference type="OMA" id="KESYAVF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="126" mass="13906" checksum="041118811BBF6647" modified="2022-05-25" version="1">MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P0K3</accession>
    <name>A0A8I5P0K3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P0K3"/>
    <dbReference type="Ensembl" id="ENSPANT00000072171.1">
        <property type="protein sequence ID" value="ENSPANP00000057558.1"/>
        <property type="gene ID" value="ENSPANG00000050222.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170325"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11376" checksum="F5EE5B00265D7FEB" modified="2022-05-25" version="1">MAAQIPIVATTSTPGIVRNSKKRPASPSHNGSSGGGYGASKKKKVSASSFAPLSKSAFSTIEEFSYIRGCPLTPPPGYLALEGRPQASLLSPRKGDEVECRSNRLWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5P2G7</accession>
    <name>A0A8I5P2G7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signaling 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RGS13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003893425.1">
        <property type="nucleotide sequence ID" value="XM_003893376.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003893426.1">
        <property type="nucleotide sequence ID" value="XM_003893377.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021784982.1">
        <property type="nucleotide sequence ID" value="XM_021929290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5P2G7"/>
    <dbReference type="Ensembl" id="ENSPANT00000061968.1">
        <property type="protein sequence ID" value="ENSPANP00000059203.1"/>
        <property type="gene ID" value="ENSPANG00000038097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101019357"/>
    <dbReference type="KEGG" id="panu:101019357"/>
    <dbReference type="CTD" id="6003"/>
    <dbReference type="GeneTree" id="ENSGT00940000158520"/>
    <dbReference type="OMA" id="EYIQPQA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045744">
        <property type="term" value="P:negative regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF32">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
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    <dbReference type="SMART" id="SM00315">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="159" mass="19193" checksum="47337BF3CB095D0F" modified="2022-05-25" version="1">MSRRNCWICKMFRDESKRPPSNLTLEEVLQWSQSFENLMATKYGPVVYAAYLKMEHSDENIQFWMACETYKKIASRWSRISRAKKLYKIYIQPQSPREINIDNSTRQTIIKNIQEPTETCFEEAQKIVYMHMERDSYPRFLKSEMYQKLLKTMQSNNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R007</accession>
    <name>A0A8I5R007_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R007"/>
    <dbReference type="Ensembl" id="ENSPANT00000063317.1">
        <property type="protein sequence ID" value="ENSPANP00000050830.1"/>
        <property type="gene ID" value="ENSPANG00000039316.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287003"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="174" mass="20479" checksum="76AED4B05F31A53A" modified="2022-05-25" version="1">MSIRSACCRDEFNSWTSLLTFCLVDLSNVDSKWCWENWLAISRKPKLDPFLTPYMKINSRWIRDLNVRPKTIKTLEENLGNTIQDIGMGKDFMSKTPKAMARKAKIDKWDQIKLKSFCTAKETTIRVNRQPTEWKKIFAIYSSDKGLISRTYKELKQIYKKKKQTIPSKSGQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R0B5</accession>
    <name>A0A8I5R0B5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ORM1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ORMDL3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ORM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003912997.1">
        <property type="nucleotide sequence ID" value="XM_003912948.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009188789.1">
        <property type="nucleotide sequence ID" value="XM_009190525.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009188790.1">
        <property type="nucleotide sequence ID" value="XM_009190526.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017806196.1">
        <property type="nucleotide sequence ID" value="XM_017950707.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R0B5"/>
    <dbReference type="SMR" id="A0A8I5R0B5"/>
    <dbReference type="Ensembl" id="ENSPANT00000077170.1">
        <property type="protein sequence ID" value="ENSPANP00000052068.1"/>
        <property type="gene ID" value="ENSPANG00000049861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101012340"/>
    <dbReference type="KEGG" id="panu:101012340"/>
    <dbReference type="CTD" id="94103"/>
    <dbReference type="GeneTree" id="ENSGT00950000183178"/>
    <dbReference type="OMA" id="WTAYILI"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002903">
        <property type="term" value="P:negative regulation of B cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900060">
        <property type="term" value="P:negative regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006940">
        <property type="term" value="P:regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="153" mass="17481" checksum="61F483CA4303E432" modified="2022-05-25" version="1">MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHVVLLSIPFVSVPVVWTLTNLIHNMGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVSLMSVLIPKLPQLHGVRIFGINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R5Z6</accession>
    <name>A0A8I5R5Z6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R5Z6"/>
    <dbReference type="SMR" id="A0A8I5R5Z6"/>
    <dbReference type="Ensembl" id="ENSPANT00000062666.1">
        <property type="protein sequence ID" value="ENSPANP00000050753.1"/>
        <property type="gene ID" value="ENSPANG00000049182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006695"/>
    <dbReference type="OMA" id="IEGCWRW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20261">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045294">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040330">
        <property type="entry name" value="LYRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="248" mass="28006" checksum="8711F968A8CEFAE3" modified="2022-05-25" version="1">MPPRLFLNSPPPQNSQLLQRFLQSNPFWKRRRPGGSKPPTIPARVSRLPTPAAAASSSTTATASSSSAAHRRRPPRSPAPSIASCIITSGNPAGRQLQEGEWERGDEGTSGRLRHDARKDVRSRRQMTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLTDTDLIKQCIDECTARIEIGLHYKIPYPRPIHLPPMGLTPLQGRGLRSQEKLRKLSKPVYLRSHDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R704</accession>
    <name>A0A8I5R704_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretogranin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Secretogranin II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SCG2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with Secretogranin III/SCG3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chromogranin/secretogranin protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908055.2">
        <property type="nucleotide sequence ID" value="XM_003908006.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R704"/>
    <dbReference type="Ensembl" id="ENSPANT00000064985.1">
        <property type="protein sequence ID" value="ENSPANP00000052940.1"/>
        <property type="gene ID" value="ENSPANG00000047209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101021542"/>
    <dbReference type="KEGG" id="panu:101021542"/>
    <dbReference type="CTD" id="7857"/>
    <dbReference type="GeneTree" id="ENSGT00390000010895"/>
    <dbReference type="OMA" id="RNAAYDD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098992">
        <property type="term" value="C:neuronal dense core vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000352">
        <property type="term" value="P:negative regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001938">
        <property type="term" value="P:positive regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018054">
        <property type="entry name" value="Chromogranin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001990">
        <property type="entry name" value="Granin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038858">
        <property type="entry name" value="ScgII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15119">
        <property type="entry name" value="SECRETOGRANIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15119:SF0">
        <property type="entry name" value="SECRETOGRANIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01271">
        <property type="entry name" value="Granin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00422">
        <property type="entry name" value="GRANINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0765">Sulfation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="634" mass="72824" checksum="91ADA0BF9C991BA2" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5RA37</accession>
    <name>A0A8I5RA37_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Immunoglobulin kappa variable 1-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IGKV1-5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5RA37"/>
    <dbReference type="SMR" id="A0A8I5RA37"/>
    <dbReference type="Ensembl" id="ENSPANT00000072137.1">
        <property type="protein sequence ID" value="ENSPANP00000060899.1"/>
        <property type="gene ID" value="ENSPANG00000048208.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153048"/>
    <dbReference type="OMA" id="INCRASH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04980">
        <property type="entry name" value="IgV_L_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000212">
        <property type="entry name" value="Immunoglobulin kappa chain variable 12-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="112" mass="12122" checksum="B12A33414125EEC6" modified="2022-05-25" version="1">MFPISGAKCDIQMTQSPSSLSASVGDRVTITCRASQTISSYLAWYQQKPGKVPKLLIYAASSLESGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQHNSHPPTVLHTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A9CB02</accession>
    <accession>A0A096NJB3</accession>
    <name>A9CB02_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA replication fork stabilization factor DONSON</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Downstream neighbor of SON (Predicted)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DONSON</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC Comparative Sequencing Initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000484">
        <property type="protein sequence ID" value="ABW97198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162257.1">
        <property type="nucleotide sequence ID" value="NM_001168786.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520709.1">
        <property type="nucleotide sequence ID" value="XM_031664849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9CB02"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013062"/>
    <dbReference type="Ensembl" id="ENSPANT00000023723.3">
        <property type="protein sequence ID" value="ENSPANP00000013062.3"/>
        <property type="gene ID" value="ENSPANG00000016795.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100137248"/>
    <dbReference type="KEGG" id="panu:100137248"/>
    <dbReference type="CTD" id="29980"/>
    <dbReference type="eggNOG" id="KOG4734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000447"/>
    <dbReference type="HOGENOM" id="CLU_021567_0_0_1"/>
    <dbReference type="OMA" id="WCLKTRV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016795">
        <property type="expression patterns" value="Expressed in optic disc and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02064">
        <property type="entry name" value="DONSON"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABW97198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013062.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="564" mass="62638" checksum="D6AA35DF8440FED6" modified="2008-01-15" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2024-11-27" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A9L8T6</accession>
    <name>RHDF1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName>Inactive rhomboid protein 1</fullName>
            <shortName>iRhom1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Rhomboid family member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RHBDF1</name>
    </gene>
    <organism>
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2007-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC comparative sequencing initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Chub I."/>
                <person name="Coleman H."/>
                <person name="Fuksenko T."/>
                <person name="Gestole M."/>
                <person name="Gregory M."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Gurson N."/>
                <person name="Han E."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Hargrove A."/>
                <person name="Hines-Harris K."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Johnson T."/>
                <person name="Knight E."/>
                <person name="Kwong P."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Merkulov G."/>
                <person name="Montemayor C."/>
                <person name="Mullikin J.C."/>
                <person name="Park M."/>
                <person name="Prasad A."/>
                <person name="Ramsahoye C."/>
                <person name="Reddix-Dugue N."/>
                <person name="Riebow N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Smith L."/>
                <person name="Stantripop S."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer, or homooligomer. Interacts with TGFA and HBEGF. Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization. Interacts with ADAM17/TACE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">Predominantly localized in the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000504">
        <property type="protein sequence ID" value="ABX52099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001162285.1">
        <property type="nucleotide sequence ID" value="NM_001168814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9L8T6"/>
    <dbReference type="SMR" id="A9L8T6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024197"/>
    <dbReference type="MEROPS" id="S54.952"/>
    <dbReference type="GlyCosmos" id="A9L8T6">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="100137277"/>
    <dbReference type="CTD" id="64285"/>
    <dbReference type="eggNOG" id="KOG2290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011531_1_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000422">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000001">
        <property type="entry name" value="Putative inactive rhomboid protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022241">
        <property type="entry name" value="iRhom1_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF4">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12595">
        <property type="entry name" value="iRhom1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0340">Growth factor binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000340109" description="Inactive rhomboid protein 1">
        <location>
            <begin position="1"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="433"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="713"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="768"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="825"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q6PIX5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q96CC6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="855" mass="97389" checksum="371C5B33C26483B4" modified="2008-02-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKR0</accession>
    <name>A0A096MKR0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminoacyl tRNA synthetase complex interacting multifunctional protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AIMP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <property type="gene ID" value="ENSPANG00000024758.3"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="expression patterns" value="Expressed in abdominal segment muscle and 65 other cell types or tissues"/>
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        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cell surface"/>
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        <property type="term" value="F:GTPase binding"/>
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        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
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    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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    </evidence>
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<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MMY2</accession>
    <name>A0A096MMY2_PAPAN</name>
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        <name evidence="10" type="primary">RASGRF2</name>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Ensembl" id="ENSPANT00000009999.3">
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        <property type="gene ID" value="ENSPANG00000010568.3"/>
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    <dbReference type="KEGG" id="panu:101003497"/>
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    <dbReference type="eggNOG" id="KOG3417">
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        <property type="component" value="Chromosome 5"/>
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        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 60 other cell types or tissues"/>
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    <dbReference type="ExpressionAtlas" id="A0A096MMY2">
        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0099170">
        <property type="term" value="P:postsynaptic modulation of chemical synaptic transmission"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="entry name" value="PH_RasGRF1_2"/>
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        <property type="entry name" value="Ras-specific guanine nucleotide-releasing factor 1 isoform 2"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
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        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
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        <property type="entry name" value="DBL_dom_sf"/>
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        <property type="entry name" value="DH_dom"/>
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        <property type="entry name" value="RASGEF_cat_dom_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="RASGEF"/>
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    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="243"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="470"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="635"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1234"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="809"/>
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            <begin position="829"/>
            <end position="873"/>
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    <feature type="coiled-coil region" evidence="4">
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            <begin position="161"/>
            <end position="188"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="761"/>
            <end position="774"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="791"/>
            <end position="800"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="855"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50010"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000967.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1237" mass="140734" checksum="A72646C318D44838" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MR92</accession>
    <name>A0A096MR92_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="8">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NAA11</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="8"/>
    <dbReference type="RefSeq" id="XP_003898763.1">
        <property type="nucleotide sequence ID" value="XM_003898714.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MR92"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002287"/>
    <dbReference type="Ensembl" id="ENSPANT00000003133.3">
        <property type="protein sequence ID" value="ENSPANP00000002287.3"/>
        <property type="gene ID" value="ENSPANG00000003252.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026539"/>
    <dbReference type="KEGG" id="panu:101026539"/>
    <dbReference type="CTD" id="84779"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163834"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_0_1"/>
    <dbReference type="OMA" id="LPENYFM"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003252">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000014">
        <property type="entry name" value="N-alpha-acetyltransferase 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF282">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002287.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="229" mass="25907" checksum="45649A0670E6515A" modified="2022-05-25" version="3">MNIRNARPDDLMNMQHCNLLCLPENYQMKYYLYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALHLYSNTLNFQISEVEPKYYADGEDAYAMKRDLSQMADELRRQVDLKKGGYVVLGSRENQETQGSTLCGSEEACQQKNPDTEESGSDSKEPKESVESTNVQDSSEGSDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRT8</accession>
    <name>A0A096MRT8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UTP3 small subunit processome component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UTP3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003898843.2">
        <property type="nucleotide sequence ID" value="XM_003898794.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRT8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002495"/>
    <dbReference type="Ensembl" id="ENSPANT00000027703.3">
        <property type="protein sequence ID" value="ENSPANP00000002495.3"/>
        <property type="gene ID" value="ENSPANG00000008263.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007784"/>
    <dbReference type="KEGG" id="panu:101007784"/>
    <dbReference type="CTD" id="57050"/>
    <dbReference type="eggNOG" id="KOG3118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044947"/>
    <dbReference type="HOGENOM" id="CLU_025161_1_0_1"/>
    <dbReference type="OMA" id="EEYIRPQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008263">
        <property type="expression patterns" value="Expressed in axillary lymph node and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="405"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002495.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="478" mass="54339" checksum="E07104D579E3B329" modified="2022-05-25" version="3">MVGRSRRRGAAKWAAVRAKAGPTLTDENGDDLGLPPSPGDTSYYQDQVDDFHEARSRAALAKGWNEVQSGDEEDGEEEEEEVLALDVDDEDDEDGGSAGEEEEENADDDGGSSVQSDAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQGQQEAEEEEREEEEEAQIIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAETRVVKDLAKVSVKEKLKMLRKESPELLELIEDLKVKLTEVKDELEPLLQLVEQGIIPPGKGSQYLRTKYNLYLNYCSNISFYLILKARRVPAHGHPVIERLVTYRNLINKLSVVDQKLSSEIRYLLTLKDDAVKKELIPEAKSTKPKPKSVSKTSAAACAVTDLSDDSDFDEEAKLKYYKEIEDRQKLKRKKEENSTEEQAVEDQNAKRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRRAKIRRRGQVREVRKEEQRYSGELSGIRAGVKKSIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRU4</accession>
    <name>A0A096MRU4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MRU4"/>
    <dbReference type="Ensembl" id="ENSPANT00000028201.3">
        <property type="protein sequence ID" value="ENSPANP00000002501.3"/>
        <property type="gene ID" value="ENSPANG00000026450.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163499"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_5_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000026450">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRU4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002501.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="434" mass="49588" checksum="1AAC3BFC5E63F083" modified="2022-05-25" version="3">MGASPSQNPALPPERFPGAKGTTSSFLKARPQNLMTFEDVAVEFTQGEWGQLNPAQKDLYREVMLENFRNLAFLGLPVSKPYVICQLEEGGEPFIVEREISTGAYSDWERRSKSKESMPSWGISKEELFQVVSVEKHIQDVLQFSKLKAACGCDGQLEMQQMKQETHLKQMSTTHKSATTLSRDYEWNGFGRSLGLRSVLVNQHSVRMGEGSYKCDTEFRQTPEGNNSQRTHPEKRSCKCNECGKSFHFQSELRRHQRCHTGEKPYECSECRRAFGHISSLIKHQRTHTGEKPYECSECGRAFSQSSSLVLHYRFHTGEKPYRCNECGRAFGHTSSLIKHQRTHTGEKPYECRECGRTFSQSSSLIVHYRFHTGEKPYKCNKCGRAFSQSSSLTQHYRFHTGEKPYKCNECGRAFAHTASLIKHQRSHAGKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MSN3</accession>
    <name>A0A096MSN3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif containing 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRIM42</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
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                <person name="Korchina V.K."/>
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                <person name="Lara F.L."/>
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                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
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                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
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                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
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                <person name="Perez Y.P."/>
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                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
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                <person name="Scheel M.S."/>
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                <person name="Simmons D.S."/>
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                <person name="Thornton R.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
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                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
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                <person name="White C.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
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                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTL1</accession>
    <name>A0A096MTL1_PAPAN</name>
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        <submittedName>
            <fullName evidence="14">Follistatin like 4</fullName>
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        <name evidence="14" type="primary">FSTL4</name>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
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                <person name="Joshi V.J."/>
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                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
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                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
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                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
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                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Secreted</location>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05736">
        <property type="entry name" value="IgI_2_Follistatin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000307">
        <property type="entry name" value="Follistatin like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000653">
        <property type="entry name" value="Follistatin like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002358">
        <property type="entry name" value="Follistatin like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000007">
        <property type="entry name" value="follistatin-related protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
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    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF9">
        <property type="entry name" value="FOLLISTATIN-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035276646" evidence="10">
        <location>
            <begin position="23"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="13">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="251"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="341"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003145.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="833" mass="92078" checksum="F0BD8DCBF9B55A34" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX58</accession>
    <name>A0A096MX58_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynein axonemal assembly factor 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat-containing protein 92</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein Monad</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DNAAF10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with PIH1D1; the interaction associates DNAAF10 with the R2TP complex. Interacts with several dynein axonemal assembly factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MX58"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004468"/>
    <dbReference type="Ensembl" id="ENSPANT00000007561.3">
        <property type="protein sequence ID" value="ENSPANP00000004468.1"/>
        <property type="gene ID" value="ENSPANG00000011915.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006128"/>
    <dbReference type="KEGG" id="panu:101006128"/>
    <dbReference type="CTD" id="116143"/>
    <dbReference type="eggNOG" id="ENOG502QRKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183091"/>
    <dbReference type="HOGENOM" id="CLU_062543_0_0_1"/>
    <dbReference type="OMA" id="CLWKYNY"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011915">
        <property type="expression patterns" value="Expressed in metanephros cortex and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990062">
        <property type="term" value="C:RPAP3/R2TP/prefoldin-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000258">
        <property type="entry name" value="WD repeat-containing protein 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="357" mass="39735" checksum="98DE10A4C47108DD" modified="2014-11-26" version="1">MSAFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGVGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPVQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX83</accession>
    <name>A0A096MX83_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DnaJ homolog subfamily B member 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNAJB14</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899059.3">
        <property type="nucleotide sequence ID" value="XM_003899010.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MX83"/>
    <dbReference type="SMR" id="A0A096MX83"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004494"/>
    <dbReference type="Ensembl" id="ENSPANT00000015210.3">
        <property type="protein sequence ID" value="ENSPANP00000004494.2"/>
        <property type="gene ID" value="ENSPANG00000006557.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021366"/>
    <dbReference type="KEGG" id="panu:101021366"/>
    <dbReference type="CTD" id="79982"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157887"/>
    <dbReference type="HOGENOM" id="CLU_043579_3_0_1"/>
    <dbReference type="OMA" id="DDRMRKK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006557">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MX83">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000004">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004494.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="379" mass="42497" checksum="BF4091DC4B31BC5A" modified="2018-02-28" version="2">MEGNRDEAEKCVEIAREALNAGNREKAQRFLQKAEKLYPLPSARALLEIIMKNGSTAGNSPHCRKPSGSGDQNKPNGTKDSTSGSGEGGKGYTKDQVDGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGNEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAGYSQQHQHRHSGHEREEERGDGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGTGQTIKMQTENLGVVYYVNKDFKNEYKGMLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDDRLRRKADALSMDNCKELERLTSLYKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MXK7</accession>
    <name>A0A096MXK7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">SEC24 homolog D, COPII coat complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SEC24D</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899170.1">
        <property type="nucleotide sequence ID" value="XM_003899121.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009205741.1">
        <property type="nucleotide sequence ID" value="XM_009207477.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MXK7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004625"/>
    <dbReference type="Ensembl" id="ENSPANT00000012533.3">
        <property type="protein sequence ID" value="ENSPANP00000004625.2"/>
        <property type="gene ID" value="ENSPANG00000016989.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017241"/>
    <dbReference type="KEGG" id="panu:101017241"/>
    <dbReference type="CTD" id="9871"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182924"/>
    <dbReference type="HOGENOM" id="CLU_004589_1_1_1"/>
    <dbReference type="OMA" id="RLCKHGD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016989">
        <property type="expression patterns" value="Expressed in pancreas and 61 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MXK7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000023">
        <property type="entry name" value="protein transport protein Sec24C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000020">
        <property type="entry name" value="protein transport protein Sec24D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000003">
        <property type="entry name" value="SEC24 homolog D, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000004">
        <property type="entry name" value="SEC24 homolog D, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
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    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
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    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF6">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC24D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="437"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="686"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="782"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="16">
        <location>
            <begin position="900"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004625.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113065" checksum="1AF088494AA95D65" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYA4</accession>
    <name>A0A096MYA4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MOGAT2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_003910482.1">
        <property type="nucleotide sequence ID" value="XM_003910433.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYA4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004910"/>
    <dbReference type="Ensembl" id="ENSPANT00000002433.3">
        <property type="protein sequence ID" value="ENSPANP00000004910.1"/>
        <property type="gene ID" value="ENSPANG00000008371.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101003810"/>
    <dbReference type="KEGG" id="panu:101003810"/>
    <dbReference type="CTD" id="80168"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234582"/>
    <dbReference type="HOGENOM" id="CLU_023995_0_1_1"/>
    <dbReference type="OMA" id="NDPKHAG"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008371">
        <property type="expression patterns" value="Expressed in ileum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990578">
        <property type="term" value="C:perinuclear endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003846">
        <property type="term" value="F:2-acylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006651">
        <property type="term" value="P:diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006640">
        <property type="term" value="P:monoacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF74">
        <property type="entry name" value="2-ACYLGLYCEROL O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="334" mass="38093" checksum="D6FBF33B52745C2A" modified="2014-11-26" version="1">MVEFAPLFVPWERRLQTLAVLQFVFSFLALAEICIVGFIALLFTRFWLLTVLYAAWWYVDRDKPRQGGRRVQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAAGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFIRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRCIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYM2</accession>
    <name>A0A096MYM2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box/LRR-repeat protein 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">F-box and leucine-rich repeat protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FBXL14</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1. Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003905846.1">
        <property type="nucleotide sequence ID" value="XM_003905797.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MYM2"/>
    <dbReference type="SMR" id="A0A096MYM2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005042"/>
    <dbReference type="Ensembl" id="ENSPANT00000017691.3">
        <property type="protein sequence ID" value="ENSPANP00000005042.2"/>
        <property type="gene ID" value="ENSPANG00000010803.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020606"/>
    <dbReference type="KEGG" id="panu:101020606"/>
    <dbReference type="CTD" id="144699"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159857"/>
    <dbReference type="HOGENOM" id="CLU_016072_7_0_1"/>
    <dbReference type="OMA" id="DQALVHI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010803">
        <property type="expression patterns" value="Expressed in amygdala and 57 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22125">
        <property type="entry name" value="F-box_FBXL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000051">
        <property type="entry name" value="F-box and leucine-rich repeat protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000075">
        <property type="entry name" value="F-box/LRR-repeat protein 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000059">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047932">
        <property type="entry name" value="FBXL14_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="10">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="10">
        <location>
            <begin position="200"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005042.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="418" mass="45886" checksum="5779961C8177779F" modified="2018-02-28" version="2">METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKEARGDFSPLFTVRTRGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZP7</accession>
    <name>A0A096MZP7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009202351.3">
        <property type="nucleotide sequence ID" value="XM_009204087.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZP7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005453"/>
    <dbReference type="Ensembl" id="ENSPANT00000012474.3">
        <property type="protein sequence ID" value="ENSPANP00000005453.3"/>
        <property type="gene ID" value="ENSPANG00000046917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101018773"/>
    <dbReference type="KEGG" id="panu:101018773"/>
    <dbReference type="eggNOG" id="ENOG502SIA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153255"/>
    <dbReference type="HOGENOM" id="CLU_012526_1_2_1"/>
    <dbReference type="OMA" id="MGVNQSW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000000803">
        <property type="expression patterns" value="Expressed in spleen"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15420">
        <property type="entry name" value="7tmA_OR2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005453.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="310" mass="35117" checksum="1B14AA6DF8830272" modified="2022-05-25" version="3">MGVNQSWIPEFILVGFQLSAEMEMLLFWIFSLLYIFSLLANGMILGLICLDHSLHTPMYFFLSHLAVIDMSYASNNVPKMLANLMNKKRTISFVPCIMQTFLYFAFAATECLILVVMSYDRYVAICHPLQYTVIMSWRVCTILALTSWSCGFALSLVHAILLLRLPFCGPRDVNHLFCEILSVLKLACADTWVNQVVIFTTCVFVLVGPLCLMLVSYMHILGAILKIQTKEGRIKALSTCSSHLCVVGLFFGIAMVVYIVPDSNQREEQEKMLSLFHSLFNPMLNPLIYSLRNAQVKGALHRALQRTQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N0R9</accession>
    <name>A0A096N0R9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antithrombin-III</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serpin C1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SERPINC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms protease inhibiting heterodimer with TMPRSS7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031514298.1">
        <property type="nucleotide sequence ID" value="XM_031658438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N0R9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005858"/>
    <dbReference type="Ensembl" id="ENSPANT00000024370.3">
        <property type="protein sequence ID" value="ENSPANP00000005858.3"/>
        <property type="gene ID" value="ENSPANG00000004954.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009366"/>
    <dbReference type="KEGG" id="panu:101009366"/>
    <dbReference type="CTD" id="462"/>
    <dbReference type="eggNOG" id="KOG2392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157967"/>
    <dbReference type="HOGENOM" id="CLU_023330_0_2_1"/>
    <dbReference type="OMA" id="CQVPTMY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004954">
        <property type="expression patterns" value="Expressed in liver and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030193">
        <property type="term" value="P:regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02045">
        <property type="entry name" value="serpinC1_AT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000008">
        <property type="entry name" value="antithrombin-III isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000030">
        <property type="entry name" value="Serpin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033829">
        <property type="entry name" value="Antithrombin_3_serpin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF53">
        <property type="entry name" value="ANTITHROMBIN-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="10 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035216665" description="Antithrombin-III" evidence="18">
        <location>
            <begin position="35"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="19">
        <location>
            <begin position="92"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005858.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="464" mass="52528" checksum="A0DDE653333153BB" modified="2022-05-25" version="3">MYSNVIGTVASGKRKVYLLSLLLIGLWDCMTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDKDNIFLSPLSVSTAFAMTKLGACNDTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPPEAINELTVLVLVNTIYFKGLWKSKFSPENTRMEPFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLTKVEQELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAIGIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N6G5</accession>
    <name>A0A096N6G5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TNF receptor superfamily member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TNFRSF14</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891049.2">
        <property type="nucleotide sequence ID" value="XM_003891000.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009213206.2">
        <property type="nucleotide sequence ID" value="XM_009214942.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009213240.2">
        <property type="nucleotide sequence ID" value="XM_009214976.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009213284.2">
        <property type="nucleotide sequence ID" value="XM_009215020.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017811925.2">
        <property type="nucleotide sequence ID" value="XM_017956436.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N6G5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008065"/>
    <dbReference type="Ensembl" id="ENSPANT00000025163.3">
        <property type="protein sequence ID" value="ENSPANP00000008065.2"/>
        <property type="gene ID" value="ENSPANG00000020403.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024608"/>
    <dbReference type="KEGG" id="panu:101024608"/>
    <dbReference type="CTD" id="8764"/>
    <dbReference type="eggNOG" id="ENOG502S1XZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162427"/>
    <dbReference type="HOGENOM" id="CLU_052667_2_0_1"/>
    <dbReference type="OMA" id="LPWTRCS"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020403">
        <property type="expression patterns" value="Expressed in thymus and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N6G5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
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    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <sequence length="282" mass="30124" checksum="1A1A45743554DD57" modified="2022-05-25" version="2">MKPPGSWGSPPRRPAPKADILTLVLYLTFLGSPCYAPALPSCKEDEYPVGSECCPKCGPGFHVRQACGEQTGTVCEPCSPGTYIAHFNGLSKCLQCQMCDPAMGLRTSRNCSTTANALCGCSPGHFCIIQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSSNATQEECQHGTKCSKWLVTEAGPGTSSSRWVWWLLSGSFIVFVIVGLILGLIICVKRRKSRGDVVKVIVSVQRKRQEAEGEAIVTEALQAPPDITTVAVEETEPAFTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N821</accession>
    <name>A0A096N821_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sequestosome 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SQSTM1</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSPANG00000012011.3"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytosol"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="277"/>
            <end position="322"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
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            <begin position="171"/>
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            <begin position="225"/>
            <end position="235"/>
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            <begin position="239"/>
            <end position="261"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="328" mass="35894" checksum="A34FA165528C7EF3" modified="2022-05-25" version="3">MAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHQGHTKLAFPSPFGHLSEGFSHSRWLRKLKHGHFGWPGWEMGPPGNWSPRPPRAGDARPGPTAESIEVDIDVEHGGKRSRLTPASPESSSTEEKNSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA40</accession>
    <name>A0A096NA40_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CYB5RL</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A096NA40"/>
    <dbReference type="SMR" id="A0A096NA40"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009537"/>
    <dbReference type="Ensembl" id="ENSPANT00000009218.3">
        <property type="protein sequence ID" value="ENSPANP00000009537.1"/>
        <property type="gene ID" value="ENSPANG00000006218.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101026362"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00920000149170"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_3_1"/>
    <dbReference type="OMA" id="YSPYWTD"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006218">
        <property type="expression patterns" value="Expressed in pancreas and 43 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NA40">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000105">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000043">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="315" mass="35821" checksum="8EC9C7813E7C93F3" modified="2014-11-26" version="1">MMGEREEDDDTEEAWLQLRPMEPLPSQCCGSGCSPCVFDLYHRDLARWEAARASKDRSLLRGPESQSCPSKLNPETFVAFCISAVDRLTKDTYRVRFALPGNSQLGLQPGQHLILRGIVDDLEIQRAYTPISPANAEGYFEVLIKCYQMGLMSRYVESWRAGDTAFWRGPFGDFFYKPNQYGELLMLAAGTGLAPMVPILQSITDNEDDETFVTLVGCFKTFESIYLKTFLQEQACFWNVRTFFVLSQESSSEQLPWSYQEKTRFGRLGQDLIKELVSCCRRKPFALVCGSAEFNKDIARCLLCAGLTEDSYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCH4</accession>
    <name>A0A096NCH4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="24 25">Serine-protein kinase ATM</fullName>
            <ecNumber evidence="6 25">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ATM</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 25">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 25">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 25">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6 25"/>
    <dbReference type="RefSeq" id="XP_021782197.2">
        <property type="nucleotide sequence ID" value="XM_021926505.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031508849.1">
        <property type="nucleotide sequence ID" value="XM_031652989.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000010521"/>
    <dbReference type="Ensembl" id="ENSPANT00000013677.3">
        <property type="protein sequence ID" value="ENSPANP00000010521.3"/>
        <property type="gene ID" value="ENSPANG00000019174.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021695"/>
    <dbReference type="CTD" id="472"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00670000098061"/>
    <dbReference type="HOGENOM" id="CLU_000178_3_1_1"/>
    <dbReference type="OMA" id="SEVYMKW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019174">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 68 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NCH4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990391">
        <property type="term" value="C:DNA repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098850">
        <property type="term" value="C:extrinsic component of synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004677">
        <property type="term" value="F:DNA-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035979">
        <property type="term" value="F:histone H2AXS139 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
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            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010521.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="3056" mass="350360" checksum="AFE745989F82349C" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NCY9</accession>
    <name>A0A096NCY9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">SH2 domain-containing protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SH2D1A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003918293.1">
        <property type="nucleotide sequence ID" value="XM_003918244.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NCY9"/>
    <dbReference type="SMR" id="A0A096NCY9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010711"/>
    <dbReference type="Ensembl" id="ENSPANT00000002474.3">
        <property type="protein sequence ID" value="ENSPANP00000010711.1"/>
        <property type="gene ID" value="ENSPANG00000001186.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025169"/>
    <dbReference type="KEGG" id="panu:101025169"/>
    <dbReference type="CTD" id="4068"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155920"/>
    <dbReference type="HOGENOM" id="CLU_125532_1_0_1"/>
    <dbReference type="OMA" id="YSPGRNE"/>
    <dbReference type="OrthoDB" id="10053436at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001186">
        <property type="expression patterns" value="Expressed in thymus and 44 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006968">
        <property type="term" value="P:cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030101">
        <property type="term" value="P:natural killer cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050860">
        <property type="term" value="P:negative regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045954">
        <property type="term" value="P:positive regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10400">
        <property type="entry name" value="SH2_SAP1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000062">
        <property type="entry name" value="SH2 domain-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017289">
        <property type="entry name" value="SH2_prot_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035876">
        <property type="entry name" value="SH2D1A_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-RELATED PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037828">
        <property type="entry name" value="SH2_p1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0391">Immunity</keyword>
    <keyword evidence="4 10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="128" mass="14187" checksum="90234E7A6614EE3D" modified="2014-11-26" version="1">MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ND07</accession>
    <name>A0A096ND07_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096ND07"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010730"/>
    <dbReference type="Ensembl" id="ENSPANT00000008910.3">
        <property type="protein sequence ID" value="ENSPANP00000010730.2"/>
        <property type="gene ID" value="ENSPANG00000015415.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015224"/>
    <dbReference type="HOGENOM" id="CLU_065464_0_2_1"/>
    <dbReference type="OMA" id="IVRTIKC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015415">
        <property type="expression patterns" value="Expressed in metanephros cortex and 37 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000005">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF46">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="8">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="8">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010730.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="177" mass="20240" checksum="833804651F436B92" modified="2022-05-25" version="2">MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVEFSLLGKKKKRLRVDKWWGNRKELTTVRTICSHVQNMIKGVTLDFCYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVQMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDLLVIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDN2</accession>
    <name>A0A096NDN2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="10">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NDUFAF7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with NDUFS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A096NDN2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010979"/>
    <dbReference type="Ensembl" id="ENSPANT00000020717.3">
        <property type="protein sequence ID" value="ENSPANP00000010979.2"/>
        <property type="gene ID" value="ENSPANG00000005245.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001588"/>
    <dbReference type="HOGENOM" id="CLU_024840_3_1_1"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005245">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDN2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000001">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010979.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="440" mass="49172" checksum="34B2F5AEA1F2E0A7" modified="2022-05-25" version="2">MTVLVRSGVGPLCAVARAAIPSIWRGKYFSSGNEPAENNPVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVYRDMLGEQGDFITSPEISQIFGELLGIWFISEWMATGKSTAFQLVELGPGRGTLVGDILRVFTQLGSVLKNCDISVHLVEVSQKLSEIQALTLTEEKVPLERNAGSPVYMKGVTKSGIPISWYRHLHDVPKGYSFYLAHEFFDVLPVHKFQKTPQGWREVFIDIDPQVSDKLRFVLAPSATPAEAFIQHDETRDHVEVCPDAGVIIEELSQRIALTGGAALVADYGHDGTKTDTFRGFCGHKLHDVLIAPGTADLTADVDFSYLRRMAQGKVASLGPIKQHTFLKNMGIDVRLKVLLDKSNEPSVRQQLLQGYDMLINPKKMGERFNFFALLPHERLEGGRHQRNAHDNLQRTSYIAKYQSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NDX7</accession>
    <name>A0A096NDX7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">p42A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSMD6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894271.1">
        <property type="nucleotide sequence ID" value="XM_003894222.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NDX7"/>
    <dbReference type="SMR" id="A0A096NDX7"/>
    <dbReference type="Ensembl" id="ENSPANT00000006168.3">
        <property type="protein sequence ID" value="ENSPANP00000011077.1"/>
        <property type="gene ID" value="ENSPANG00000014295.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997045"/>
    <dbReference type="KEGG" id="panu:100997045"/>
    <dbReference type="CTD" id="9861"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046608"/>
    <dbReference type="HOGENOM" id="CLU_031814_0_0_1"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014295">
        <property type="expression patterns" value="Expressed in pons and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NDX7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000004">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="389" mass="45559" checksum="1300CD9C1667BC6F" modified="2014-11-26" version="1">MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCRSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NE87</accession>
    <name>A0A096NE87_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">F-box and leucine rich repeat protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FBXL3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009190297.2">
        <property type="nucleotide sequence ID" value="XM_009192033.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009190299.2">
        <property type="nucleotide sequence ID" value="XM_009192035.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NE87"/>
    <dbReference type="SMR" id="A0A096NE87"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011196"/>
    <dbReference type="Ensembl" id="ENSPANT00000010012.3">
        <property type="protein sequence ID" value="ENSPANP00000011196.3"/>
        <property type="gene ID" value="ENSPANG00000016434.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009403"/>
    <dbReference type="KEGG" id="panu:101009403"/>
    <dbReference type="CTD" id="26224"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159395"/>
    <dbReference type="HOGENOM" id="CLU_033637_0_0_1"/>
    <dbReference type="OMA" id="RWNQAFH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016434">
        <property type="expression patterns" value="Expressed in thyroid gland and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22178">
        <property type="entry name" value="F-box_FBXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23957">
        <property type="entry name" value="FBXL3_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000010">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF18">
        <property type="entry name" value="F-BOX AND LEUCINE RICH REPEAT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011196.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="428" mass="48737" checksum="CA30014788928E84" modified="2022-05-25" version="3">MKRGGRDSDRNSSEEGTTEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEU8</accession>
    <name>A0A096NEU8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Retinol dehydrogenase 10</fullName>
            <ecNumber evidence="5">1.1.1.300</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RDH10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003902913.1">
        <property type="nucleotide sequence ID" value="XM_003902864.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NEU8"/>
    <dbReference type="SMR" id="A0A096NEU8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011434"/>
    <dbReference type="Ensembl" id="ENSPANT00000011133.3">
        <property type="protein sequence ID" value="ENSPANP00000011434.1"/>
        <property type="gene ID" value="ENSPANG00000012143.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021993"/>
    <dbReference type="KEGG" id="panu:101021993"/>
    <dbReference type="CTD" id="157506"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157063"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_5_1"/>
    <dbReference type="OMA" id="KQAMNNN"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="UniPathway" id="UPA00912"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012143">
        <property type="expression patterns" value="Expressed in pigmented layer of retina and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NEU8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060449">
        <property type="term" value="P:bud elongation involved in lung branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043583">
        <property type="term" value="P:ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031076">
        <property type="term" value="P:embryonic camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048703">
        <property type="term" value="P:embryonic viscerocranium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001656">
        <property type="term" value="P:metanephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043584">
        <property type="term" value="P:nose development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060431">
        <property type="term" value="P:primary lung bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002138">
        <property type="term" value="P:retinoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000177">
        <property type="entry name" value="Retinol dehydrogenase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="341" mass="38087" checksum="D10ABE05E7D11FC6" modified="2014-11-26" version="1">MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NEU9</accession>
    <name>A0A096NEU9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glypican-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GPC1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NEU9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011435"/>
    <dbReference type="Ensembl" id="ENSPANT00000010433.3">
        <property type="protein sequence ID" value="ENSPANP00000011435.2"/>
        <property type="gene ID" value="ENSPANG00000024475.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244897"/>
    <dbReference type="HOGENOM" id="CLU_024658_2_0_1"/>
    <dbReference type="OMA" id="CNSYCRN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024475">
        <property type="expression patterns" value="Expressed in amygdala and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001016">
        <property type="term" value="P:positive regulation of skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019803">
        <property type="entry name" value="Glypican_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF8">
        <property type="entry name" value="GLYPICAN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01207">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13 16" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="14 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011435.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="782" mass="83755" checksum="A9F41F54BC28715A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGK3</accession>
    <name>A0A096NGK3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YIPF1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891965.2">
        <property type="nucleotide sequence ID" value="XM_003891916.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009207158.2">
        <property type="nucleotide sequence ID" value="XM_009208894.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009207165.2">
        <property type="nucleotide sequence ID" value="XM_009208901.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009207169.2">
        <property type="nucleotide sequence ID" value="XM_009208905.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021797515.2">
        <property type="nucleotide sequence ID" value="XM_021941823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGK3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012082"/>
    <dbReference type="Ensembl" id="ENSPANT00000011139.3">
        <property type="protein sequence ID" value="ENSPANP00000012082.3"/>
        <property type="gene ID" value="ENSPANG00000001227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020742"/>
    <dbReference type="KEGG" id="panu:101020742"/>
    <dbReference type="CTD" id="54432"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010157"/>
    <dbReference type="HOGENOM" id="CLU_059606_1_1_1"/>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001227">
        <property type="expression patterns" value="Expressed in dorsal thalamus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NGK3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF4">
        <property type="entry name" value="PROTEIN YIPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="10">
        <location>
            <begin position="101"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012082.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="306" mass="34262" checksum="522C665CF2B454AD" modified="2022-05-25" version="3">MAAVDDLQFEEFGSAATSLAANPDATTVNIEDPGETPKHQPGPPRGSGREEDDELLGNDDSDKTELLAGQKKSSPFWTFEYYQTFFDVDTYQVFDRIKGSLLPIPGKNFVRLYIRSNPDLYGPFWICATLVFAIAISGNLSNFLIHLGEKTYHYVPEFRKVSIAATIIYAYAWLIPLALWGFLMWRNSKVMNIVSYSFLEIVCVYGYSLFIYIPTAILWIIPQKAVRWILVMIALGISGSVLSMTFWPAVREDNRRVALATIVTIVLLHMLLSVGCLAYFFDAPEMDHLPTTTATLNQTVAAAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NHU5</accession>
    <name>A0A096NHU5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">FYVE, RhoGEF and PH domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FGD2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009203302.2">
        <property type="nucleotide sequence ID" value="XM_009205038.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NHU5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012543"/>
    <dbReference type="Ensembl" id="ENSPANT00000009209.3">
        <property type="protein sequence ID" value="ENSPANP00000012543.2"/>
        <property type="gene ID" value="ENSPANG00000013431.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005824"/>
    <dbReference type="KEGG" id="panu:101005824"/>
    <dbReference type="CTD" id="221472"/>
    <dbReference type="eggNOG" id="KOG4424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161251"/>
    <dbReference type="HOGENOM" id="CLU_011755_2_1_1"/>
    <dbReference type="OMA" id="WTEKCPP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013431">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 49 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:filopodium assembly"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="FYVE_FGD1_2_4"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd13386">
        <property type="entry name" value="PH1_FGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13236">
        <property type="entry name" value="PH2_FGD1-4"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.40.10:FF:000061">
        <property type="entry name" value="FYVE, RhoGEF and PH domain containing 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.900.10:FF:000013">
        <property type="entry name" value="FYVE, RhoGEF and PH domain-containing protein 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.29.30:FF:000102">
        <property type="entry name" value="FYVE, RhoGEF and PH domain-containing protein 4"/>
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    <dbReference type="FunFam" id="2.30.29.30:FF:000113">
        <property type="entry name" value="FYVE, RhoGEF and PH domain-containing protein 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
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        <property type="entry name" value="FGD1-4_PH2"/>
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    <dbReference type="InterPro" id="IPR037797">
        <property type="entry name" value="FGD2_PH1"/>
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    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
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    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
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        <property type="entry name" value="Znf_FYVE-rel"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2"/>
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    <dbReference type="SMART" id="SM00325">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    <dbReference type="SUPFAM" id="SSF50729">
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    <dbReference type="PROSITE" id="PS50010">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="15">
        <location>
            <begin position="102"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="319"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="458"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="544"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012543.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="655" mass="75019" checksum="2DC8C39A897E8287" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIV6</accession>
    <name>A0A096NIV6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Meprin A subunit</fullName>
            <ecNumber evidence="16">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endopeptidase-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">MEP1A</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.</text>
            <dbReference type="EC" id="3.4.24.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20 21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003897744.1">
        <property type="nucleotide sequence ID" value="XM_003897695.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NIV6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012904"/>
    <dbReference type="Ensembl" id="ENSPANT00000020395.3">
        <property type="protein sequence ID" value="ENSPANP00000012904.2"/>
        <property type="gene ID" value="ENSPANG00000005760.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101011175"/>
    <dbReference type="KEGG" id="panu:101011175"/>
    <dbReference type="CTD" id="4224"/>
    <dbReference type="GeneTree" id="ENSGT00940000164139"/>
    <dbReference type="OMA" id="FEMFRLR"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005760">
        <property type="expression patterns" value="Expressed in ileum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017090">
        <property type="term" value="C:meprin A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038004">
        <property type="term" value="P:epidermal growth factor receptor ligand maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03783">
        <property type="entry name" value="MATH_Meprin_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04282">
        <property type="entry name" value="ZnMc_meprin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000930">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000037">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000009">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008294">
        <property type="entry name" value="Meprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034038">
        <property type="entry name" value="ZnMP_meprin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF824">
        <property type="entry name" value="MEPRIN A SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001196">
        <property type="entry name" value="Meprin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 16 20" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 16 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339750" description="Meprin A subunit" evidence="21">
        <location>
            <begin position="22"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="27">
        <location>
            <begin position="66"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="25">
        <location>
            <begin position="267"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="26">
        <location>
            <begin position="431"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="670"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" evidence="17 20">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012904.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="746" mass="84514" checksum="7BA103A69E26649D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NK17</accession>
    <name>A0A096NK17_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium inwardly rectifying channel subfamily J member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KCNJ4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905589.1">
        <property type="nucleotide sequence ID" value="XM_003905540.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NK17"/>
    <dbReference type="SMR" id="A0A096NK17"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013321"/>
    <dbReference type="Ensembl" id="ENSPANT00000019085.3">
        <property type="protein sequence ID" value="ENSPANP00000013321.2"/>
        <property type="gene ID" value="ENSPANG00000010777.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002150"/>
    <dbReference type="KEGG" id="panu:101002150"/>
    <dbReference type="CTD" id="3761"/>
    <dbReference type="eggNOG" id="KOG3827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234586"/>
    <dbReference type="HOGENOM" id="CLU_022738_11_1_1"/>
    <dbReference type="OMA" id="GGIIQMM"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010777">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000039">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003273">
        <property type="entry name" value="K_chnl_inward-rec_Kir2.3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF53">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01326">
        <property type="entry name" value="KIR23CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="185"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="12">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013321.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="445" mass="49488" checksum="ADD9CD0D50FEC4C5" modified="2018-02-28" version="2">MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPGAGGPAAGSGGAAPAAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NK81</accession>
    <name>A0A096NK81_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Metastasis associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MTA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metastasis-associated protein family.</text>
    </comment>
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            <begin position="283"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00093454"/>
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    </evidence>
    <sequence length="715" mass="80776" checksum="546345DE2679466F" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NKN2</accession>
    <name>A0A096NKN2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tryptase gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TPSG1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="Bgee" id="ENSPANG00000006969">
        <property type="expression patterns" value="Expressed in ascending colon and 3 other cell types or tissues"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Brain-specific serine protease 4"/>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NL82</accession>
    <name>A0A096NL82_PAPAN</name>
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        <submittedName>
            <fullName evidence="9">Serine/arginine repetitive matrix 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">SRRM2</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <text evidence="2">Belongs to the CWC21 family.</text>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1862"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2070"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2097"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2317"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2426"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2455"/>
            <end position="2473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2474"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2515"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2533"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2608"/>
            <end position="2648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2651"/>
            <end position="2668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2669"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2707"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2717"/>
            <end position="2729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2743"/>
            <end position="2752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="2752" mass="299786" checksum="3015B0F0752B9BE5" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLB7</accession>
    <name>A0A096NLB7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 75A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF75A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003916491.2">
        <property type="nucleotide sequence ID" value="XM_003916442.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017808614.2">
        <property type="nucleotide sequence ID" value="XM_017953125.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLB7"/>
    <dbReference type="Ensembl" id="ENSPANT00000019087.3">
        <property type="protein sequence ID" value="ENSPANP00000013775.3"/>
        <property type="gene ID" value="ENSPANG00000006903.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026202"/>
    <dbReference type="KEGG" id="panu:101026202"/>
    <dbReference type="CTD" id="7627"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162456"/>
    <dbReference type="HOGENOM" id="CLU_002678_49_4_1"/>
    <dbReference type="OMA" id="HLQRESC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006903">
        <property type="expression patterns" value="Expressed in axillary lymph node and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NLB7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000720">
        <property type="entry name" value="zinc finger protein 18 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001005">
        <property type="entry name" value="Zinc finger protein 75A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001261">
        <property type="entry name" value="Zinc finger protein 75a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001549">
        <property type="entry name" value="Zinc finger protein 75a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001340">
        <property type="entry name" value="zinc finger protein 75D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF83">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="15">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="235"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013775.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="537" mass="62415" checksum="C18AF734BB62B8C9" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NMC3</accession>
    <name>A0A096NMC3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 18" type="primary">PIF1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_021796336.2">
        <property type="nucleotide sequence ID" value="XM_021940644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NMC3"/>
    <dbReference type="Ensembl" id="ENSPANT00000003773.3">
        <property type="protein sequence ID" value="ENSPANP00000014132.2"/>
        <property type="gene ID" value="ENSPANG00000016755.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026325"/>
    <dbReference type="KEGG" id="panu:101026325"/>
    <dbReference type="CTD" id="80119"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063561"/>
    <dbReference type="HOGENOM" id="CLU_001613_7_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016755">
        <property type="expression patterns" value="Expressed in bone marrow and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NMC3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160225">
        <property type="term" value="F:G-quadruplex unwinding activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000805">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="17">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="15">
        <location>
            <begin position="206"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="16">
        <location>
            <begin position="458"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="13">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014132.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="641" mass="69795" checksum="A4E48826950C548E" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NNN1</accession>
    <name>A0A096NNN1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein NDRG2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDRG2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with CTNNB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901562.1">
        <property type="nucleotide sequence ID" value="XM_003901513.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003901563.1">
        <property type="nucleotide sequence ID" value="XM_003901514.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003901564.1">
        <property type="nucleotide sequence ID" value="XM_003901515.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003901566.1">
        <property type="nucleotide sequence ID" value="XM_003901517.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209334.1">
        <property type="nucleotide sequence ID" value="XM_009211070.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209335.1">
        <property type="nucleotide sequence ID" value="XM_009211071.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209337.1">
        <property type="nucleotide sequence ID" value="XM_009211073.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009209338.1">
        <property type="nucleotide sequence ID" value="XM_009211074.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017816485.1">
        <property type="nucleotide sequence ID" value="XM_017960996.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NNN1"/>
    <dbReference type="MEROPS" id="S33.989"/>
    <dbReference type="Ensembl" id="ENSPANT00000008114.4">
        <property type="protein sequence ID" value="ENSPANP00000014591.1"/>
        <property type="gene ID" value="ENSPANG00000021105.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101015126"/>
    <dbReference type="CTD" id="57447"/>
    <dbReference type="eggNOG" id="KOG2931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182872"/>
    <dbReference type="OMA" id="KTCFQPL"/>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021105">
        <property type="expression patterns" value="Expressed in medial globus pallidus and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NNN1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904706">
        <property type="term" value="P:negative regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090361">
        <property type="term" value="P:regulation of platelet-derived growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010574">
        <property type="term" value="P:regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990874">
        <property type="term" value="P:vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000034">
        <property type="entry name" value="NDRG2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 13" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000014591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="371" mass="40686" checksum="FCD77459A2215E1D" modified="2014-11-26" version="1">MAELQEVQITEEKPLLPGQTPEAAKEAELAAQILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTVIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ65</accession>
    <name>A0A096NQ65_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DNAI4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3, and DYNLT1. Interacts with DYNLT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NQ65"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015159"/>
    <dbReference type="Ensembl" id="ENSPANT00000004563.3">
        <property type="protein sequence ID" value="ENSPANP00000015159.2"/>
        <property type="gene ID" value="ENSPANG00000005715.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156209"/>
    <dbReference type="HOGENOM" id="CLU_015820_0_0_1"/>
    <dbReference type="OMA" id="VFVWSIK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005715">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000373">
        <property type="entry name" value="WD repeat domain 78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000379">
        <property type="entry name" value="WD repeat domain 78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="699"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015159.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="847" mass="94969" checksum="0EF0C6E8AC1805D6" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ79</accession>
    <name>A0A096NQ79_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(N)/adenosine(N+1) in rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(N)/N(6)-dimethyladenosine(N+1) in rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:78527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19105"/>
            <dbReference type="Rhea" id="RHEA-COMP:19106"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM. Bound to the maturing mtSSU until the late stages of assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="17"/>
    <dbReference type="RefSeq" id="XP_031523566.1">
        <property type="nucleotide sequence ID" value="XM_031667706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQ79"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015173"/>
    <dbReference type="Ensembl" id="ENSPANT00000010993.3">
        <property type="protein sequence ID" value="ENSPANP00000015173.1"/>
        <property type="gene ID" value="ENSPANG00000007489.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000083818.1">
        <property type="protein sequence ID" value="ENSPANP00000051781.1"/>
        <property type="gene ID" value="ENSPANG00000046477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116268556"/>
    <dbReference type="CTD" id="51106"/>
    <dbReference type="eggNOG" id="KOG0821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183142"/>
    <dbReference type="HOGENOM" id="CLU_041220_7_0_1"/>
    <dbReference type="OMA" id="RIEQPFK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007489">
        <property type="expression patterns" value="Expressed in ascending colon and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.100:FF:000004">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000109">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 17" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="18">
        <location>
            <begin position="43"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055263"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="345" mass="39511" checksum="858A47DB4C6D5C98" modified="2014-11-26" version="1">MAAPGKLSTCRLPPLPTIREIIKLFRLQATKQLSQNFLLDLRLTDKIVRKAGNLANAYVYEVGPGPGGITRSILNADVAELLVVEKDTRFIPGLQMLSEAAPGKLRIVHGDVLTFKVEKAFSESLKRPWEDDPPNVHIIGNLPFSVSTPLIIKWLENISCRDGPFVYGRTQMTLTFQKEVAERLTANTGSKQRSRLSVMAQYLCNVRHIFTIPGRAFVPKPEVDVGVVHFTPLIQPKIEQPFKLVEKVVQNVFQFRRKYCHRGLGMLFPEAERLENTGRLLELADIDPTLRPRQLSISHFKSLCEVYRRMCDEDPQLFAYNFREELRQRKIKKKEKQDDAKSYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSB7</accession>
    <name>A0A096NSB7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Immunoglobulin lambda variable 4-69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IGLV4-69</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NSB7"/>
    <dbReference type="Ensembl" id="ENSPANT00000016447.4">
        <property type="protein sequence ID" value="ENSPANP00000015937.2"/>
        <property type="gene ID" value="ENSPANG00000022435.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4P8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153934"/>
    <dbReference type="OMA" id="YCQTWTT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022435">
        <property type="expression patterns" value="Expressed in caecum and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001671">
        <property type="entry name" value="Immunoglobulin lambda variable 4-69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="12" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015937.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="116" mass="12706" checksum="989621FA6D04B865" modified="2018-02-28" version="2">QPVLTQSPSASASLGASVKLTCTLSSGHSSYTIAWHQQQQGKAPRYLMWLKSDGSHSKADGIPDRFSGSSSGAERYLTISNLQSEDEADYYCQTWTTDIHTVTQADEEVRQNPQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSQ4</accession>
    <name>A0A096NSQ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCA2 and CDKN1A-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904447.1">
        <property type="nucleotide sequence ID" value="XM_003904398.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NSQ4"/>
    <dbReference type="Ensembl" id="ENSPANT00000024705.3">
        <property type="protein sequence ID" value="ENSPANP00000016075.1"/>
        <property type="gene ID" value="ENSPANG00000020319.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998878"/>
    <dbReference type="KEGG" id="panu:100998878"/>
    <dbReference type="CTD" id="56647"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000696"/>
    <dbReference type="HOGENOM" id="CLU_068770_1_1_1"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020319">
        <property type="expression patterns" value="Expressed in perirenal fat and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NSQ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="314" mass="35910" checksum="65870472B12C95FC" modified="2014-11-26" version="1">MASRPKRRAVESGVPQPPDPLVQRDEEEEDEVEDEDEDDDDSDEGEDEEDNVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSDDDVDEDEVFGFISLLNLTERKGTQCAEQIQELILSFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINIPPQIALPMYQQLQKELAEAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKLSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NSX7</accession>
    <name>A0A096NSX7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAP30 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SAP30BP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003913488.1">
        <property type="nucleotide sequence ID" value="XM_003913439.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NSX7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016148"/>
    <dbReference type="Ensembl" id="ENSPANT00000025404.3">
        <property type="protein sequence ID" value="ENSPANP00000016148.1"/>
        <property type="gene ID" value="ENSPANG00000020147.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006160"/>
    <dbReference type="KEGG" id="panu:101006160"/>
    <dbReference type="CTD" id="29115"/>
    <dbReference type="eggNOG" id="KOG2959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007870"/>
    <dbReference type="HOGENOM" id="CLU_053268_0_1_1"/>
    <dbReference type="OMA" id="XSFSERV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020147">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NSX7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="308" mass="33917" checksum="343859DABCDB9E02" modified="2014-11-26" version="1">MAGKKNVLSSLAVYAEDSEPESDGETGIEAMGSAAEEKGGLVSDAYGEDDFSRLGGDEDGYEEEEDENSRQSEDDDSETEKPEADDPKDNTEAEKRDPQELVASFSERVRNMSPDEIKIPPEPPGRCSNHLQDKIQKLYERKIKEGMDMNYIIQRKKEFRNPSIYEKLIQFCAIDELGTNYPKDMFDPHGWSEDSYYEALAKAQKIEMDKLEKAKKERTKIEFVTGTKKGTTTNATATTTTTASTAVADAQKRKSKWDSAIPVTTIAQPTILTTTATLPAVVTVTTSASGSKTTVISAVGTIVKKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTH5</accession>
    <name>A0A096NTH5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARF like GTPase 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARL16</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096NTH5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016346"/>
    <dbReference type="Ensembl" id="ENSPANT00000003699.3">
        <property type="protein sequence ID" value="ENSPANP00000016346.2"/>
        <property type="gene ID" value="ENSPANG00000019328.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111327"/>
    <dbReference type="HOGENOM" id="CLU_040729_14_1_1"/>
    <dbReference type="OMA" id="ETTFSMP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019328">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016346.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="196" mass="20968" checksum="BBCD96EE98F3B9B6" modified="2018-02-28" version="2">MRVGGGRALLRAELRVPGGAKHGMCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVGTNLTDIVAQRKITIRELGGCMGPIWSSYYGNCRSLLFMMDASDPTQLSASCVQLLGLLSSEQLAEASVLILFNKIDLPCYMAMEEMKSLIRLPDIIACAKQNITTAEISAREGTGLAEVLAWLQATHRANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NX42</accession>
    <name>A0A096NX42_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxynucleotidyltransferase terminal-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Terminal deoxynucleotidyltransferase-interacting factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNTTIP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer and homodimer. A minor proportion may form homotrimers. Interacts with ZNF541. Interacts with the terminal deoxynucleotidyltransferase DNTT. Interacts with TRERF1. Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and MIDEAS; this complex assembles into a tetramer that contains four copies of each protein chain. Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2. Identified in a complex with KCTD19, HDAC1, HDAC2 and ZNF541.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003904728.1">
        <property type="nucleotide sequence ID" value="XM_003904679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NX42"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017632"/>
    <dbReference type="Ensembl" id="ENSPANT00000006672.3">
        <property type="protein sequence ID" value="ENSPANP00000017632.1"/>
        <property type="gene ID" value="ENSPANG00000003909.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009224"/>
    <dbReference type="KEGG" id="panu:101009224"/>
    <dbReference type="CTD" id="116092"/>
    <dbReference type="eggNOG" id="KOG4801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047836"/>
    <dbReference type="HOGENOM" id="CLU_073342_0_0_1"/>
    <dbReference type="OMA" id="LAENHHM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003909">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NX42">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="9">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="10">
        <location>
            <begin position="211"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="329" mass="37017" checksum="810492D338023C3A" modified="2014-11-26" version="1">MGATGDAEQPRGPSGAERGGLELGDAGAAGQLVLTNPWNIMIKHRQVQRRGRRSQMTTSFTDPAISMDLLRAVLQPSINEEIQTVFNKYMKFFQKAALNVRDNVGEEVDTEQLIQEACRSCLEQAKLLFSDGEKVIPRLTHELPGIKRGRQAEEECAHRGSPLPKKRKGRPPGHILSSDRAAAGMVWKAKSCEPIRREGPKWDPARLNESTTFVLGSRANKALGMGGTRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATGGKMAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLPSWMVEKMRKYMETLRTENEHRAVEAPPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXH8</accession>
    <name>A0A096NXH8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Slit homolog 3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLIT3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="9555.ENSPANP00000017772"/>
    <dbReference type="Ensembl" id="ENSPANT00000007449.3">
        <property type="protein sequence ID" value="ENSPANP00000017772.2"/>
        <property type="gene ID" value="ENSPANG00000005313.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159322"/>
    <dbReference type="HOGENOM" id="CLU_001431_2_0_1"/>
    <dbReference type="OMA" id="CIVVHQE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005313">
        <property type="expression patterns" value="Expressed in mesenteric fat pad and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NXH8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048495">
        <property type="term" value="F:Roundabout binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003180">
        <property type="term" value="P:aortic valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061364">
        <property type="term" value="P:apoptotic process involved in luteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003181">
        <property type="term" value="P:atrioventricular valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050919">
        <property type="term" value="P:negative chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070100">
        <property type="term" value="P:negative regulation of chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051414">
        <property type="term" value="P:response to cortisol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035385">
        <property type="term" value="P:Roundabout signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000054">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000062">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000099">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000004">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000376">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000375">
        <property type="entry name" value="Slit guidance ligand 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000047">
        <property type="entry name" value="Slit guidance ligand 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000032">
        <property type="entry name" value="Slit homolog 2 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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        <property type="entry name" value="Cys_knot_C"/>
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    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF9">
        <property type="entry name" value="SLIT HOMOLOG 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014123093" description="Slit homolog 3 protein" evidence="16">
        <location>
            <begin position="34"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="962"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1003"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1041"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1126"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="1165"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1375"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1415"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="17">
        <location>
            <begin position="1456"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1312"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1379"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1400"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1419"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1441"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017772.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168439" checksum="C8F607C5784B830D" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXL5</accession>
    <name>A0A096NXL5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 88B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM88B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM88 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031519146.1">
        <property type="nucleotide sequence ID" value="XM_031663286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXL5"/>
    <dbReference type="SMR" id="A0A096NXL5"/>
    <dbReference type="Ensembl" id="ENSPANT00000006359.3">
        <property type="protein sequence ID" value="ENSPANP00000017810.3"/>
        <property type="gene ID" value="ENSPANG00000005469.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011699"/>
    <dbReference type="KEGG" id="panu:101011699"/>
    <dbReference type="CTD" id="643965"/>
    <dbReference type="eggNOG" id="ENOG502RYZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111599"/>
    <dbReference type="HOGENOM" id="CLU_2518277_0_0_1"/>
    <dbReference type="OMA" id="EEQLCAW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005469">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033355">
        <property type="entry name" value="TMEM88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 88-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28628:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 88B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017810.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="162" mass="17036" checksum="CCD70565479A237C" modified="2022-05-25" version="3">MSEQGREMEEEEGGGASDTAPMLPRGPPDHQASALPCPGWPGPLLLPGRLVAGLLLHLLLPATAFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALFSDRGSAALIVFGLLSLPPLLVLASAVRARLARRLRPLLPPPAGTPGPRRPPGRPDGDEQLCAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NY54</accession>
    <name>A0A096NY54_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Osteoclast stimulatory transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">OCSTAMP</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NY54"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018014"/>
    <dbReference type="Ensembl" id="ENSPANT00000029092.3">
        <property type="protein sequence ID" value="ENSPANP00000018014.3"/>
        <property type="gene ID" value="ENSPANG00000011739.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153269"/>
    <dbReference type="HOGENOM" id="CLU_045128_0_0_1"/>
    <dbReference type="OMA" id="ARCVFSM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071391">
        <property type="term" value="P:cellular response to estrogen stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072674">
        <property type="term" value="P:multinuclear osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034241">
        <property type="term" value="P:positive regulation of macrophage fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045672">
        <property type="term" value="P:positive regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090290">
        <property type="term" value="P:positive regulation of osteoclast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF3">
        <property type="entry name" value="OSTEOCLAST STIMULATORY TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="7">
        <location>
            <begin position="254"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018014.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="565" mass="61495" checksum="C54F5246C595560E" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NYD1</accession>
    <name>A0A096NYD1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Telomeric repeat-binding factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">TTAGGG repeat-binding factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Telomeric DNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TERF2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1, ACD and POT1. Interacts with NBN; interaction takes place with unphosphorylated NBN during G1 phase and prevents to prevent ATM activation and non-homologous end joining repair. Interacts with SLX4/BTBD12. Interacts with DCLRE1B/Apollo and TERF2IP/RAP1; the interaction is direct.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031658139.1"/>
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        <property type="component" value="Chromosome 18"/>
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        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:male germ cell nucleus"/>
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    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
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        <property type="term" value="F:double-stranded telomeric DNA binding"/>
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        <property type="term" value="F:enzyme binding"/>
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        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
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    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="30"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="57"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="425"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00065753"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00071647"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081836"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00083088"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018093.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="542" mass="59600" checksum="83E9BB9AE255DC2A" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZX8</accession>
    <name>A0A096NZX8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Solute carrier family 22 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Organic cation transporter 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">SLC22A3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-adrenaline(out) = (R)-adrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73875"/>
            <dbReference type="ChEBI" id="CHEBI:71406"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(R)-noradrenaline(out) = (R)-noradrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73871"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(R)-salsolinol(in) = (R)-salsolinol(out)</text>
            <dbReference type="Rhea" id="RHEA:74791"/>
            <dbReference type="ChEBI" id="CHEBI:194082"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)</text>
            <dbReference type="Rhea" id="RHEA:74787"/>
            <dbReference type="ChEBI" id="CHEBI:90039"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>agmatine(out) = agmatine(in)</text>
            <dbReference type="Rhea" id="RHEA:72131"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dopamine(out) = dopamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73863"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>guanidine(out) = guanidine(in)</text>
            <dbReference type="Rhea" id="RHEA:73883"/>
            <dbReference type="ChEBI" id="CHEBI:30087"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>histamine(out) = histamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73879"/>
            <dbReference type="ChEBI" id="CHEBI:58432"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>serotonin(out) = serotonin(in)</text>
            <dbReference type="Rhea" id="RHEA:73867"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>spermidine(in) = spermidine(out)</text>
            <dbReference type="Rhea" id="RHEA:35039"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tyramine(in) = tyramine(out)</text>
            <dbReference type="Rhea" id="RHEA:74783"/>
            <dbReference type="ChEBI" id="CHEBI:327995"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031523420.1">
        <property type="nucleotide sequence ID" value="XM_031667560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NZX8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018653"/>
    <dbReference type="Ensembl" id="ENSPANT00000024068.3">
        <property type="protein sequence ID" value="ENSPANP00000018653.3"/>
        <property type="gene ID" value="ENSPANG00000025907.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006621"/>
    <dbReference type="KEGG" id="panu:101006621"/>
    <dbReference type="CTD" id="6581"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160810"/>
    <dbReference type="HOGENOM" id="CLU_001265_33_5_1"/>
    <dbReference type="OMA" id="NYWCRIP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025907">
        <property type="expression patterns" value="Expressed in aorta and 50 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015651">
        <property type="term" value="F:quaternary ammonium group transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090494">
        <property type="term" value="P:dopamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048241">
        <property type="term" value="P:epinephrine transport"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051625">
        <property type="term" value="P:epinephrine uptake"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051615">
        <property type="term" value="P:histamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051620">
        <property type="term" value="P:norepinephrine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051610">
        <property type="term" value="P:serotonin uptake"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17379">
        <property type="entry name" value="MFS_SLC22A1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000165">
        <property type="entry name" value="Solute carrier family 22 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="270"/>
            <end position="288"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="380"/>
            <end position="401"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="29">
        <location>
            <begin position="98"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00037001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00072456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018653.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="555" mass="61014" checksum="B341BDBB807F2299" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P1N1</accession>
    <name>A0A096P1N1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor RFX3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Regulatory factor X 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RFX3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P1N1"/>
    <dbReference type="Ensembl" id="ENSPANT00000025290.3">
        <property type="protein sequence ID" value="ENSPANP00000019256.3"/>
        <property type="gene ID" value="ENSPANG00000025143.3"/>
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    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="HOGENOM" id="CLU_010393_1_1_1"/>
    <dbReference type="OMA" id="FYRNSSM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000025143">
        <property type="expression patterns" value="Expressed in thymus and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P1N1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000078">
        <property type="term" value="P:positive regulation of type B pancreatic cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050796">
        <property type="term" value="P:regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072560">
        <property type="term" value="P:type B pancreatic cell maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007668">
        <property type="entry name" value="RFX1_trans_act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF20">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04589">
        <property type="entry name" value="RFX1_trans_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="12">
        <location>
            <begin position="194"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019256.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="781" mass="87363" checksum="32AB2EF8281FB309" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P2M1</accession>
    <name>A0A096P2M1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">B-cell CLL/lymphoma 6 member B protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bcl6-associated zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BCL6B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Associates with BCL6 through the BTB domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003912261.1">
        <property type="nucleotide sequence ID" value="XM_003912212.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017805794.1">
        <property type="nucleotide sequence ID" value="XM_017950305.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P2M1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000019596"/>
    <dbReference type="Ensembl" id="ENSPANT00000023392.3">
        <property type="protein sequence ID" value="ENSPANP00000019596.1"/>
        <property type="gene ID" value="ENSPANG00000024201.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014362"/>
    <dbReference type="KEGG" id="panu:101014362"/>
    <dbReference type="CTD" id="255877"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159844"/>
    <dbReference type="HOGENOM" id="CLU_024196_2_0_1"/>
    <dbReference type="OMA" id="VCGARFN"/>
    <dbReference type="OrthoDB" id="5560627at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024201">
        <property type="expression patterns" value="Expressed in heart and 30 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="FunFam" id="3.30.710.10:FF:000097">
        <property type="entry name" value="B-cell CLL/lymphoma 6 member B protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
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        <property type="entry name" value="Zinc finger protein 16 like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="B-CELL LYMPHOMA 6 PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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        <property type="entry name" value="zf-C2H2"/>
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        <property type="entry name" value="ZnF_C2H2"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="POZ domain"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00065558"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081988"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019596.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="474" mass="51080" checksum="3A1ED47744494F82" modified="2014-11-26" version="1">MGSPAAPEGALGYVREFTRHSSDVLGNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGRAGVGVDVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPLEAEPPTPPTAPPPGSPRRSEGHPDPPTESRSCSQGPPSPASPDPKACNWKKYKYIVLNSQASQAGSLVGERSSGQPCPQARLPSGDEASSSSSSEEGPIPGPQSRLSPTAATVQFKCGAPASTPHLLTSQAQDTSGSPSERARPLPGSEFFSCQNCEAVAGCSSGLDPLVPGDEDKPYKCQLCRSSFRYKGNLASHRTVHTGEKPYHCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHFRHKSQLRLHLRQKHGAATNTKVHYHILGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P3X2</accession>
    <name>A0A096P3X2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Schlafen family member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLFN14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003912626.5"/>
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        <property type="gene ID" value="ENSPANG00000022979.3"/>
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    <dbReference type="GeneID" id="101018887"/>
    <dbReference type="KEGG" id="panu:101018887"/>
    <dbReference type="CTD" id="342618"/>
    <dbReference type="eggNOG" id="ENOG502QWKG">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00410000025651"/>
    <dbReference type="HOGENOM" id="CLU_037282_0_0_1"/>
    <dbReference type="OMA" id="LHHGVLW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022979">
        <property type="expression patterns" value="Expressed in bone marrow and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036345">
        <property type="term" value="P:platelet maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.30:FF:000001">
        <property type="entry name" value="Schlafen family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031450">
        <property type="entry name" value="Poxin-SLFN/SLFN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
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    <dbReference type="InterPro" id="IPR038461">
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    </dbReference>
    <dbReference type="InterPro" id="IPR048729">
        <property type="entry name" value="SLFN_GTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF30">
        <property type="entry name" value="PROTEIN SLFN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17057">
        <property type="entry name" value="B3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21026">
        <property type="entry name" value="SLFN_GTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poxin-Schlafen/Schlafen-like N-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen AlbA-2" evidence="1">
        <location>
            <begin position="206"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen GTPase-like" evidence="3">
        <location>
            <begin position="401"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020047.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="912" mass="103887" checksum="47FBE31D2CE524B0" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P449</accession>
    <name>A0A096P449_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNGT2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096P449"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020124"/>
    <dbReference type="Ensembl" id="ENSPANT00000019908.3">
        <property type="protein sequence ID" value="ENSPANP00000020124.2"/>
        <property type="gene ID" value="ENSPANG00000022835.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263525"/>
    <dbReference type="HOGENOM" id="CLU_168377_2_1_1"/>
    <dbReference type="OMA" id="SWLEIAW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022835">
        <property type="expression patterns" value="Expressed in pineal body and 51 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020124.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="89" mass="10110" checksum="A640039E02370453" modified="2018-02-28" version="2">MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGPTFNALLLLLGRASWLELAWSRTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P4W7</accession>
    <name>A0A096P4W7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable ATP-dependent RNA helicase DHX40</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DEAH box protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DHX40</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable ATP-dependent RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_021783941.1">
        <property type="nucleotide sequence ID" value="XM_021928249.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P4W7"/>
    <dbReference type="SMR" id="A0A096P4W7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020392"/>
    <dbReference type="Ensembl" id="ENSPANT00000002488.3">
        <property type="protein sequence ID" value="ENSPANP00000020392.2"/>
        <property type="gene ID" value="ENSPANG00000022266.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023354"/>
    <dbReference type="KEGG" id="panu:101023354"/>
    <dbReference type="CTD" id="79665"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158902"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_7_1"/>
    <dbReference type="OMA" id="VTSKPFM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022266">
        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P4W7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17984">
        <property type="entry name" value="DEXHc_DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000009">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001082">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF271">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="63"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="263"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020392.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="779" mass="88612" checksum="132514AEDD80041A" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P561</accession>
    <name>A0A096P561_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cyclin dependent kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDK1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003903969.1">
        <property type="nucleotide sequence ID" value="XM_003903920.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009213143.1">
        <property type="nucleotide sequence ID" value="XM_009214879.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P561"/>
    <dbReference type="STRING" id="9555.ENSPANP00000020486"/>
    <dbReference type="Ensembl" id="ENSPANT00000003507.3">
        <property type="protein sequence ID" value="ENSPANP00000020486.3"/>
        <property type="gene ID" value="ENSPANG00000022031.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101025881"/>
    <dbReference type="KEGG" id="panu:101025881"/>
    <dbReference type="CTD" id="983"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153335"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022031">
        <property type="expression patterns" value="Expressed in caecum and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P561">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097125">
        <property type="term" value="C:cyclin B1-CDK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035173">
        <property type="term" value="F:histone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061523">
        <property type="term" value="P:cilium disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904860">
        <property type="term" value="P:DNA synthesis involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902850">
        <property type="term" value="P:microtubule cytoskeleton organization involved in mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990506">
        <property type="term" value="P:mitotic DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007077">
        <property type="term" value="P:mitotic nuclear membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905448">
        <property type="term" value="P:positive regulation of mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062033">
        <property type="term" value="P:positive regulation of mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902423">
        <property type="term" value="P:regulation of attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046105">
        <property type="term" value="P:thymidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07861">
        <property type="entry name" value="STKc_CDK1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020486.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="297" mass="34081" checksum="162D79448EFE491F" modified="2022-05-25" version="3">MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDVDNQIKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P5V9</accession>
    <name>A0A096P5V9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoinositide 3-kinase adapter protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">B-cell adapter for phosphoinositide 3-kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">B-cell phosphoinositide 3-kinase adapter protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIK3AP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooligomer. Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003904111.2">
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            <begin position="8"/>
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        <location>
            <begin position="181"/>
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            <begin position="145"/>
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            <begin position="571"/>
            <end position="590"/>
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            <begin position="654"/>
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            <begin position="697"/>
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            <begin position="707"/>
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            <begin position="717"/>
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</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUA3</accession>
    <name>A0A0A0MUA3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heterogeneous nuclear ribonucleoprotein M</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HNRNPM</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subunit">
        <text evidence="14">Identified in the spliceosome C complex. Interacts with PPIA/CYPA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_009193378.4"/>
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        <property type="protein sequence ID" value="ENSPANP00000001145.2"/>
        <property type="gene ID" value="ENSPANG00000000283.4"/>
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        <property type="expression patterns" value="Expressed in thymus and 66 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RRM1_hnRNPM"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd12659">
        <property type="entry name" value="RRM2_hnRNPM"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd12661">
        <property type="entry name" value="RRM3_hnRNPM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
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        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myelin expression factor 2"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="HnRNP_M_PY-NLS"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M"/>
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        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
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        <property type="entry name" value="HnRNP_M_NLS"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="165"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="614"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001145.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="691" mass="73621" checksum="028646C136D3CBD1" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MUV4</accession>
    <name>A0A0A0MUV4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
            <ecNumber evidence="15">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">CYP2S1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cytochromes P450 are a group of heme-thiolate monooxygenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A0A0MUV4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003713"/>
    <dbReference type="Ensembl" id="ENSPANT00000003245.3">
        <property type="protein sequence ID" value="ENSPANP00000003713.2"/>
        <property type="gene ID" value="ENSPANG00000016669.4"/>
    </dbReference>
    <dbReference type="VGNC" id="VGNC:81844">
        <property type="gene designation" value="CYP2S1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162131"/>
    <dbReference type="HOGENOM" id="CLU_001570_22_3_1"/>
    <dbReference type="OMA" id="WPVDIFP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016669">
        <property type="expression patterns" value="Expressed in esophagus and 39 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MUV4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11026">
        <property type="entry name" value="CYP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008067">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF23">
        <property type="entry name" value="CYTOCHROME P450 2S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01684">
        <property type="entry name" value="EP450ICYP2A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035152671" description="Cytochrome P450" evidence="17">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003713.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="VGNC" id="VGNC:81844"/>
        </source>
    </evidence>
    <sequence length="504" mass="55851" checksum="1451A192B5348772" modified="2022-05-25" version="2">MEATGTWALLLALALLLLLTLALSGTRARGQLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTIAMLERTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVEAFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAMVRAAGGTLLGVSSRGGQTYEMCSWFLWPLPGPHKQLLHHISTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEKQNPDTEFTNKNMLMTIIYLLFAGTMTVSATVGYTLLLLMKYPHVQKRVHEELTRELGSGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPSIFKHPEEFNPDHFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESSCPLDSLSLKPTISGLFNIPPAFQLQVRPTDLHSTTQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MV25</accession>
    <name>A0A0A0MV25_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Intercellular adhesion molecule 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ICAM3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with moesin/MSN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. ICAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003914922.1">
        <property type="nucleotide sequence ID" value="XM_003914873.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MV25"/>
    <dbReference type="Ensembl" id="ENSPANT00000001247.3">
        <property type="protein sequence ID" value="ENSPANP00000004833.1"/>
        <property type="gene ID" value="ENSPANG00000011402.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022079"/>
    <dbReference type="KEGG" id="panu:101022079"/>
    <dbReference type="CTD" id="3385"/>
    <dbReference type="eggNOG" id="ENOG502RZRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159005"/>
    <dbReference type="HOGENOM" id="CLU_036160_1_1_1"/>
    <dbReference type="OMA" id="QAKCPQR"/>
    <dbReference type="OrthoDB" id="6250964at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011402">
        <property type="expression patterns" value="Expressed in bone marrow and 63 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MV25">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20997">
        <property type="entry name" value="IgI_N_ICAM-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000194">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000459">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000648">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002232">
        <property type="entry name" value="Intercellular adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000338">
        <property type="entry name" value="intercellular adhesion molecule 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003988">
        <property type="entry name" value="ICAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048679">
        <property type="entry name" value="ICAM1_3_5_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013768">
        <property type="entry name" value="ICAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047012">
        <property type="entry name" value="ICAM_VCAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003987">
        <property type="entry name" value="ICAM_VCAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771:SF17">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21146">
        <property type="entry name" value="ICAM1_3_5_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03921">
        <property type="entry name" value="ICAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01473">
        <property type="entry name" value="ICAM"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01472">
        <property type="entry name" value="ICAMVCAM1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001974562" description="Intercellular adhesion molecule 3" evidence="19">
        <location>
            <begin position="30"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="20">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="20">
        <location>
            <begin position="321"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="20">
        <location>
            <begin position="408"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="547" mass="59533" checksum="99F507F94FB942F4" modified="2015-01-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWT3</accession>
    <name>A0A0A0MWT3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SIGLEC family like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SIGLECL1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWT3"/>
    <dbReference type="Ensembl" id="ENSPANT00000016019.3">
        <property type="protein sequence ID" value="ENSPANP00000010326.2"/>
        <property type="gene ID" value="ENSPANG00000010474.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RWXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="HOGENOM" id="CLU_096844_0_0_1"/>
    <dbReference type="OMA" id="ACQEPKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010474">
        <property type="expression patterns" value="Expressed in testis and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010326.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="196" mass="21162" checksum="B0E69399EF6EB7DD" modified="2018-02-28" version="2">MLPLLQLAPAKLLNSSCSLEKTLQCSCSFHGIPTPSVQWWMGGVPVGVDGMDGSLQVTSTVLGPWANSTINLTEEPEMGMRLLCEGKNQNGTHALSILLMSRKSSLASQAFVKGLIQGAIYAGIVIVLLFLCLLPLIVKHIRKKQAKKAAAIRAKKSSKVRASQELKMSLKPEEPGKPIVTTFSESHILEKQDKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MX36</accession>
    <name>A0A0A0MX36_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NSF attachment protein alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NAPA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915842.1">
        <property type="nucleotide sequence ID" value="XM_003915793.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MX36"/>
    <dbReference type="SMR" id="A0A0A0MX36"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011271"/>
    <dbReference type="Ensembl" id="ENSPANT00000015444.3">
        <property type="protein sequence ID" value="ENSPANP00000011271.3"/>
        <property type="gene ID" value="ENSPANG00000023325.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026785"/>
    <dbReference type="KEGG" id="panu:101026785"/>
    <dbReference type="CTD" id="8775"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005826"/>
    <dbReference type="HOGENOM" id="CLU_046329_0_1_1"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023325">
        <property type="expression patterns" value="Expressed in cerebellum and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MX36">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070044">
        <property type="term" value="C:synaptobrevin 2-SNAP-25-syntaxin-1a complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000028">
        <property type="entry name" value="beta-soluble NSF attachment protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF23">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
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    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011271.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="295" mass="33233" checksum="7704A619A441E609" modified="2022-05-25" version="3">MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MXH5</accession>
    <name>A0A0A0MXH5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium calcium-activated channel subfamily N member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KCNN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0A0MXH5"/>
    <dbReference type="Ensembl" id="ENSPANT00000011391.3">
        <property type="protein sequence ID" value="ENSPANP00000017495.2"/>
        <property type="gene ID" value="ENSPANG00000010107.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182904"/>
    <dbReference type="HOGENOM" id="CLU_014617_5_0_1"/>
    <dbReference type="OMA" id="PPCQWPP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010107">
        <property type="expression patterns" value="Expressed in amygdala and 31 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MXH5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000022">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000027">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
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        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01451">
        <property type="entry name" value="SKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="125"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="137"/>
            <end position="160"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="277"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="346"/>
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    <feature type="domain" description="Calmodulin-binding" evidence="13">
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            <begin position="384"/>
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            <begin position="65"/>
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            <begin position="508"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SMART" id="SM01053"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017495.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="543" mass="60006" checksum="4D858018075B8066" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LGC9</accession>
    <name>A0A2I3LGC9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subunit">
        <text evidence="11">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000022491.2"/>
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    <dbReference type="OMA" id="WVAVIRY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000034302">
        <property type="expression patterns" value="Expressed in duodenum and 42 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000942">
        <property type="entry name" value="Immunoglobulin heavy variable 3-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="12" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250325" description="Ig-like domain-containing protein" evidence="14">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022491.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="146" mass="16282" checksum="19E3F4BCF964B95B" modified="2022-05-25" version="2">MEFGLSWVFLLVAILKGVQCEVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKALEWVAVIWYDGSQKYYADSVKDRFTISRDNSKNMLYLQMNNLRLEDTAVYYCARDTVRGGRCEPRHKPPCRNAGGNQRQGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LRJ7</accession>
    <name>A0A2I3LRJ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">POU2F1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity. Interacts with NR3C1, AR, PGR and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_021786637.1">
        <property type="nucleotide sequence ID" value="XM_021930945.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LRJ7"/>
    <dbReference type="SMR" id="A0A2I3LRJ7"/>
    <dbReference type="Ensembl" id="ENSPANT00000053632.2">
        <property type="protein sequence ID" value="ENSPANP00000026085.2"/>
        <property type="gene ID" value="ENSPANG00000006362.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997629"/>
    <dbReference type="KEGG" id="panu:100997629"/>
    <dbReference type="CTD" id="5451"/>
    <dbReference type="GeneTree" id="ENSGT00940000157831"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006362">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 47 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LRJ7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045703">
        <property type="entry name" value="POU2F1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000972">
        <property type="entry name" value="TF_octamer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF47">
        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19536">
        <property type="entry name" value="POU2F1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00029">
        <property type="entry name" value="OCTAMER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="16">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="402"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="528"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026085.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="766" mass="78521" checksum="143FAE5E92DFB54B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LV22</accession>
    <name>A0A2I3LV22_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Embryonal stem cell-specific gene 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHDC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897857.1">
        <property type="nucleotide sequence ID" value="XM_003897808.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003901065.2">
        <property type="nucleotide sequence ID" value="XM_003901016.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LV22"/>
    <dbReference type="SMR" id="A0A2I3LV22"/>
    <dbReference type="Ensembl" id="ENSPANT00000057080.2">
        <property type="protein sequence ID" value="ENSPANP00000027310.1"/>
        <property type="gene ID" value="ENSPANG00000029964.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101008028"/>
    <dbReference type="GeneID" id="101015684"/>
    <dbReference type="KEGG" id="panu:101008028"/>
    <dbReference type="KEGG" id="panu:101015684"/>
    <dbReference type="CTD" id="340168"/>
    <dbReference type="GeneTree" id="ENSGT00940000154353"/>
    <dbReference type="HOGENOM" id="CLU_169085_0_0_1"/>
    <dbReference type="OMA" id="KLRTRWM"/>
    <dbReference type="OrthoDB" id="9510166at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12795">
        <property type="entry name" value="FILIA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000079">
        <property type="entry name" value="developmental pluripotency-associated 5 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031952">
        <property type="entry name" value="MOEP19_KH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31368">
        <property type="entry name" value="DEVELOPMENT PLURPOTENCY-ASSOCIATED PROTEIN 1/5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31368:SF4">
        <property type="entry name" value="DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16005">
        <property type="entry name" value="MOEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH-like RNA-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054456"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="116" mass="13480" checksum="FB87AC4856BCF622" modified="2022-05-25" version="1">MGTLPARRNIPPWVKVPEDLKDPEVFQVQTRLLKAMFGPDGSRIPYIEQVSKAMLELKALESSDLTEVVVYGSYLYKLRTKWMLQSMAEWHRQRQERGMLKLAEAMTALELGPWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M7R1</accession>
    <name>A0A2I3M7R1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">EPHB1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
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                <person name="Vee V.V."/>
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                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
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                <person name="Nazareth L.N."/>
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    <feature type="binding site" evidence="22 24">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="61"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000031781.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117809" checksum="050FD9995F9201EC" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MGN6</accession>
    <name>A0A2I3MGN6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Calcium and integrin-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Calmyrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">CIB1</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cell projection</location>
            <location evidence="9">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_009209199.1">
        <property type="nucleotide sequence ID" value="XM_009210935.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MGN6"/>
    <dbReference type="Ensembl" id="ENSPANT00000057880.2">
        <property type="protein sequence ID" value="ENSPANP00000034745.2"/>
        <property type="gene ID" value="ENSPANG00000021466.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101000735"/>
    <dbReference type="CTD" id="10519"/>
    <dbReference type="GeneTree" id="ENSGT00940000158927"/>
    <dbReference type="OMA" id="DDGELCK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021466">
        <property type="expression patterns" value="Expressed in ascending colon and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008427">
        <property type="term" value="F:calcium-dependent protein kinase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007113">
        <property type="term" value="P:endomitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045653">
        <property type="term" value="P:negative regulation of megakaryocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030220">
        <property type="term" value="P:platelet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070886">
        <property type="term" value="P:positive regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033630">
        <property type="term" value="P:positive regulation of cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
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    <dbReference type="GO" id="GO:0001954">
        <property type="term" value="P:positive regulation of cell-matrix adhesion"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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    </dbReference>
    <dbReference type="GO" id="GO:2000256">
        <property type="term" value="P:positive regulation of male germ cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of cell division"/>
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        <property type="term" value="P:response to ischemia"/>
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        <property type="term" value="P:spermatid development"/>
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        <property type="term" value="P:thrombopoietin-mediated signaling pathway"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CIBP"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45791:SF3">
        <property type="entry name" value="CALCIUM AND INTEGRIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_1"/>
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    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="16" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="21" id="KW-0106">Calcium</keyword>
    <keyword evidence="24" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="30" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="28" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="20" id="KW-0221">Differentiation</keyword>
    <keyword evidence="29" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="25" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0519">Myristate</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0677">Repeat</keyword>
    <keyword evidence="23" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="EF-hand" evidence="33">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="33">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004495"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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            <dbReference type="ARBA" id="ARBA00022657"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00040936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00041782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000034745.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="258" mass="28794" checksum="0B0BF58202CD89C5" modified="2022-05-25" version="2">MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVEQSLLAQVPFEQILSLPELKANPFKERICRVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFARYDSGAPAFWVPAGPDLLPLGLGHCYRRWCQGERKPQSTHTGPAKLAVSPRAGAALLVKASPLATAIVIALCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MIC6</accession>
    <name>A0A2I3MIC6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TTLL1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003905707.1">
        <property type="nucleotide sequence ID" value="XM_003905658.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009215698.1">
        <property type="nucleotide sequence ID" value="XM_009217434.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017800846.1">
        <property type="nucleotide sequence ID" value="XM_017945357.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MIC6"/>
    <dbReference type="Ensembl" id="ENSPANT00000053425.2">
        <property type="protein sequence ID" value="ENSPANP00000035542.2"/>
        <property type="gene ID" value="ENSPANG00000008687.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023657"/>
    <dbReference type="KEGG" id="panu:101023657"/>
    <dbReference type="CTD" id="25809"/>
    <dbReference type="GeneTree" id="ENSGT00940000156720"/>
    <dbReference type="OMA" id="DWNFYWS"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008687">
        <property type="expression patterns" value="Expressed in pineal body and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MIC6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021702">
        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061523">
        <property type="term" value="P:cilium disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002395">
        <property type="term" value="P:immune response in nasopharyngeal-associated lymphoid tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120197">
        <property type="term" value="P:mucociliary clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120222">
        <property type="term" value="P:regulation of blastocyst development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035542.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="423" mass="48919" checksum="2AECCCBB07A2FE91" modified="2022-05-25" version="2">MAGKVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVETGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAGKDESGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRSRDSGRAVLTTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MP95</accession>
    <name>A0A2I3MP95_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal peptide, CUB and EGF-like domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SCUBE3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms homooligomers. Forms heterooligomers with SCUBE1 and SCUBE2. Interacts with TGFBR2 through the CUB domain; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with BMP2, BMP4 and BMP7; the interaction is mediated by the CUB domain. Interacts with BMPR1A, BMPR1B and BMPR2; the interaction with BMPR1A and BMPR1B is BMP2- and BMP4-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897536.1">
        <property type="nucleotide sequence ID" value="XM_003897487.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MP95"/>
    <dbReference type="Ensembl" id="ENSPANT00000057086.2">
        <property type="protein sequence ID" value="ENSPANP00000037608.1"/>
        <property type="gene ID" value="ENSPANG00000021152.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101014030"/>
    <dbReference type="KEGG" id="panu:101014030"/>
    <dbReference type="CTD" id="222663"/>
    <dbReference type="GeneTree" id="ENSGT00940000153185"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021152">
        <property type="expression patterns" value="Expressed in thyroid gland and 27 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MP95">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000032">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000002">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000006">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000110">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000030">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000035">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000124">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000161">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF2">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014169929" description="Signal peptide, CUB and EGF-like domain-containing protein 3" evidence="13">
        <location>
            <begin position="21"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="804"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000037608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="993" mass="109148" checksum="7AEC946EB231B5DB" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MQX1</accession>
    <name>A0A2I3MQX1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SKI family transcriptional corepressor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SKOR1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031525087.1">
        <property type="nucleotide sequence ID" value="XM_031669227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MQX1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000038065"/>
    <dbReference type="Ensembl" id="ENSPANT00000032342.2">
        <property type="protein sequence ID" value="ENSPANP00000038065.1"/>
        <property type="gene ID" value="ENSPANG00000016593.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018214"/>
    <dbReference type="KEGG" id="panu:101018214"/>
    <dbReference type="CTD" id="390598"/>
    <dbReference type="GeneTree" id="ENSGT00940000158440"/>
    <dbReference type="OMA" id="YLCTPER"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016593">
        <property type="expression patterns" value="Expressed in cerebellum and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21080">
        <property type="entry name" value="DHD_Skor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000001">
        <property type="entry name" value="SKI family transcriptional corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000003">
        <property type="entry name" value="SKI family transcriptional corepressor 1 homolog-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF8">
        <property type="entry name" value="SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014185393" evidence="9">
        <location>
            <begin position="23"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="777"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="861"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000038065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="964" mass="99759" checksum="76F00FE6A8B4906D" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MSZ4</accession>
    <name>A0A2I3MSZ4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleosome assembly protein 1 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NAP1L1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPANP00000038869.2"/>
        <property type="gene ID" value="ENSPANG00000009165.3"/>
    </dbReference>
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    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
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        <property type="expression patterns" value="Expressed in testis and 65 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.1120.90:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="404"/>
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            <begin position="1"/>
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            <begin position="11"/>
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            <begin position="404"/>
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    </feature>
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        <source>
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            <dbReference type="RuleBase" id="RU003876"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUA9</accession>
    <name>A0A2I3MUA9_PAPAN</name>
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        <submittedName>
            <fullName evidence="11">Cell division cycle 14B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CDC14B</name>
    </gene>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUA9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000039250"/>
    <dbReference type="Ensembl" id="ENSPANT00000040077.2">
        <property type="protein sequence ID" value="ENSPANP00000039250.1"/>
        <property type="gene ID" value="ENSPANG00000024637.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101021000"/>
    <dbReference type="KEGG" id="panu:101021000"/>
    <dbReference type="CTD" id="8555"/>
    <dbReference type="GeneTree" id="ENSGT00940000155950"/>
    <dbReference type="OMA" id="WVSPKFI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024637">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MUA9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000006">
        <property type="entry name" value="Dual specificity protein phosphatase CDC14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000031">
        <property type="entry name" value="dual specificity protein phosphatase CDC14B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="214"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="297"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="498" mass="56753" checksum="FCC32900D2F9A3C9" modified="2018-02-28" version="1">MKRKSERRSSWAAAPPCSRRCSSTSPGVKKIRSSTQQDLRRRDSQDDVYLDITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHSVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTSLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTVILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MVK0</accession>
    <name>A0A2I3MVK0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Serine/threonine-protein kinase Nek2</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Never in mitosis A-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">NEK2</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
            <location evidence="4">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003893179.1">
        <property type="nucleotide sequence ID" value="XM_003893130.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MVK0"/>
    <dbReference type="SMR" id="A0A2I3MVK0"/>
    <dbReference type="Ensembl" id="ENSPANT00000058831.2">
        <property type="protein sequence ID" value="ENSPANP00000039631.2"/>
        <property type="gene ID" value="ENSPANG00000005932.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022515"/>
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    <keyword evidence="28" id="KW-0137">Centromere</keyword>
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    <keyword evidence="23 33" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
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            <dbReference type="ARBA" id="ARBA00082682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="445" mass="51692" checksum="2A9D17B6E1851AA2" modified="2022-05-25" version="2">MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTETEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNGIITRMLNLKDYHRPSVEEILENPLIADLVAEEQRRNLERRGRQLGEPEKLQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKEQKFLSLASSPELLNLPSSVIKKKVHFSGESKENVMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N1D3</accession>
    <name>A0A2I3N1D3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CNOT11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003909093.1">
        <property type="nucleotide sequence ID" value="XM_003909044.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N1D3"/>
    <dbReference type="SMR" id="A0A2I3N1D3"/>
    <dbReference type="Ensembl" id="ENSPANT00000058618.2">
        <property type="protein sequence ID" value="ENSPANP00000041823.2"/>
        <property type="gene ID" value="ENSPANG00000023665.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997980"/>
    <dbReference type="KEGG" id="panu:100997980"/>
    <dbReference type="CTD" id="55571"/>
    <dbReference type="GeneTree" id="ENSGT00390000006356"/>
    <dbReference type="OMA" id="PDHSVQW"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000023665">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N1D3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000041823.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="510" mass="55304" checksum="71EEF57036EB1D3E" modified="2022-05-25" version="2">MPGGGASAASCRLLTAAEQRVSREAAGSASRSGFGGSGGGRGGASGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHFRLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPARGGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDISGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N2V1</accession>
    <name>A0A2I3N2V1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type E3 ubiquitin-protein ligase PPIL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CYC4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Probable inactive peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PPIL2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1. Interacts with isoform 2 of BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_009215136.1">
        <property type="nucleotide sequence ID" value="XM_009216872.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017800648.1">
        <property type="nucleotide sequence ID" value="XM_017945159.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N2V1"/>
    <dbReference type="Ensembl" id="ENSPANT00000052224.2">
        <property type="protein sequence ID" value="ENSPANP00000042323.2"/>
        <property type="gene ID" value="ENSPANG00000020040.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011336"/>
    <dbReference type="KEGG" id="panu:101011336"/>
    <dbReference type="CTD" id="23759"/>
    <dbReference type="GeneTree" id="ENSGT00940000153189"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020040">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3N2V1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000018">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="23">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="22">
        <location>
            <begin position="285"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="449"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000042323.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="520" mass="58754" checksum="73CC5590C1F58B1B" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N7Z4</accession>
    <name>A0A2I3N7Z4_PAPAN</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N7Z4"/>
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        <property type="protein sequence ID" value="ENSPANP00000044150.2"/>
        <property type="gene ID" value="ENSPANG00000008202.3"/>
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    <dbReference type="GeneTree" id="ENSGT00740000115564"/>
    <dbReference type="OMA" id="LFTTVMD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="Bgee" id="ENSPANG00000008202">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 61 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="185"/>
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        <location>
            <begin position="677"/>
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        <location>
            <begin position="199"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044150.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="736" mass="84830" checksum="11632CB92A38BCEB" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3N817</accession>
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        <alternativeName>
            <fullName evidence="10">GST class-pi</fullName>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate</text>
            <dbReference type="Rhea" id="RHEA:50260"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:132200"/>
            <dbReference type="ChEBI" id="CHEBI:132201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:50261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50800"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133370"/>
            <dbReference type="ChEBI" id="CHEBI:133769"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:50801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50804"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133396"/>
            <dbReference type="ChEBI" id="CHEBI:133771"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:50805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50808"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133396"/>
            <dbReference type="ChEBI" id="CHEBI:133772"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:50809"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with CDK5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A2I3N817"/>
    <dbReference type="STRING" id="9555.ENSPANP00000044012"/>
    <dbReference type="Ensembl" id="ENSPANT00000011502.3">
        <property type="protein sequence ID" value="ENSPANP00000044012.2"/>
        <property type="gene ID" value="ENSPANG00000038888.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163435"/>
    <dbReference type="OMA" id="ETTHIDM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004067">
        <property type="expression patterns" value="Expressed in pineal body and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03210">
        <property type="entry name" value="GST_C_Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000047">
        <property type="entry name" value="Glutathione S-transferase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000071">
        <property type="entry name" value="Glutathione S-transferase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000392">
        <property type="entry name" value="Glutathione S-transferase pi 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003082">
        <property type="entry name" value="GST_pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF255">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01268">
        <property type="entry name" value="GSTRNSFRASEP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035254290" description="Glutathione S-transferase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="86"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044012.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="213" mass="23651" checksum="9501CA0746D17A5F" modified="2022-05-25" version="2">MRRWSFVVAAAACAISRCAALRMLLADQGQSWKEEVVTMETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTFLRHLGRTLGLYGKDQREAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVARLSARPKLKAFLASPEHVNLPINGNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NA36</accession>
    <name>A0A2I3NA36_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017815290.2">
        <property type="nucleotide sequence ID" value="XM_017959801.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NA36"/>
    <dbReference type="STRING" id="9555.ENSPANP00000044870"/>
    <dbReference type="Ensembl" id="ENSPANT00000059406.2">
        <property type="protein sequence ID" value="ENSPANP00000044870.2"/>
        <property type="gene ID" value="ENSPANG00000031039.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101011084"/>
    <dbReference type="GeneTree" id="ENSGT00530000064208"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031039">
        <property type="expression patterns" value="Expressed in testis and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF66">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044870.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="250" mass="28485" checksum="1C0A102DD9EBC75C" modified="2022-05-25" version="2">MKTSLDLTNYPLMMLTAGLLIPNSLCCFFIFPWCQPCLHIRAAFHDPMALRSTNHNTKPAMIRRPPTVVCYICGREYGTKSISIHEPQCLKKWHNENNLLPKELRRPVPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCNVCGRTFLPDRLIVHQRSYQKTDIWSKQLTQGHTELELRNSEGSKLRTAGLPIPHSSIAICMLDFITNKITHTNTIDLTNLKHFVHYLSNKANGNLSIRAVLLLVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NAB6</accession>
    <name>A0A2I3NAB6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp3 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SP3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907675.1">
        <property type="nucleotide sequence ID" value="XM_003907626.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NAB6"/>
    <dbReference type="Ensembl" id="ENSPANT00000035350.2">
        <property type="protein sequence ID" value="ENSPANP00000044846.2"/>
        <property type="gene ID" value="ENSPANG00000005418.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101001112"/>
    <dbReference type="KEGG" id="panu:101001112"/>
    <dbReference type="CTD" id="6670"/>
    <dbReference type="GeneTree" id="ENSGT00940000155099"/>
    <dbReference type="OMA" id="TCTQVES"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005418">
        <property type="expression patterns" value="Expressed in thyroid gland and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NAB6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22537">
        <property type="entry name" value="SP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000044846.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="780" mass="81951" checksum="B2D61325C3137F9D" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MY03</accession>
    <name>A0A8I5MY03_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
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                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
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                <person name="Hollins B.H."/>
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                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
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                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
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                <person name="Lorensuhewa L.L."/>
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                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
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                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
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                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MY03"/>
    <dbReference type="Ensembl" id="ENSPANT00000061950.1">
        <property type="protein sequence ID" value="ENSPANP00000050740.1"/>
        <property type="gene ID" value="ENSPANG00000038978.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="LEFMICP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF6">
        <property type="entry name" value="HIGH MOBILITY GROUP AT-HOOK 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000050740.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    <sequence length="134" mass="15708" checksum="74EEA326B57408D5" modified="2022-05-25" version="1">IIYPLFSISSRSNNKCKQLSSPRRCSAYEVVILYSFTFFCFFFFFFFETESHSVTQAGVQWCDFSSLQPLPPRFKRFSCLSLPSSWDYRHVPPCPANFCIFSRDRVSPCWPGWSRYLEFMICPPRPPKVLGLQA</sequence>
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    <name>A0A8I5N441_PAPAN</name>
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        <recommendedName>
            <fullName evidence="3">DUF1725 domain-containing protein</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
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                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
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                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Santibanez J.S."/>
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                <person name="Sisson I.S."/>
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                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Woodworth J.W."/>
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                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 11"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="115" mass="13556" checksum="D5EBB55E0F5C0B6D" modified="2022-05-25" version="1">MCMFIAALFTISKTWNQHKCPSVIDWIKKMWYIYTMEYYAAIKKDEFVSFVGTWMQLETIILSKLSQEQKTKHRMFSLLRLELNNEITWTQGRGTSHTRAIMRKGAGRSCIGSYT</sequence>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N462</accession>
    <name>A0A8I5N462_PAPAN</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
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                <person name="Bandaranaike D.B."/>
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                <person name="Berhane-Mersha D.B."/>
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                <person name="Gubbala S.G."/>
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                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
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                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
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                <person name="Le T.-K.L."/>
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                <person name="Legall-Iii F.L."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
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                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
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                <person name="Munidasa M.M."/>
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                <person name="Nguyen T.N."/>
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                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
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                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="Ensembl" id="ENSPANT00000074724.1">
        <property type="protein sequence ID" value="ENSPANP00000055015.1"/>
        <property type="gene ID" value="ENSPANG00000045823.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286943"/>
    <dbReference type="OMA" id="TTGACYY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="84" mass="9161" checksum="5E315052D6904440" modified="2022-05-25" version="1">MNKMREKTESHSIARLECSGLISAHWNLRLPGSSDSPPSASRVAGTTGACYYIQLIFGLLVTNFILVETGFHHISQNGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N4A0</accession>
    <name>A0A8I5N4A0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N4A0"/>
    <dbReference type="Ensembl" id="ENSPANT00000083341.1">
        <property type="protein sequence ID" value="ENSPANP00000055087.1"/>
        <property type="gene ID" value="ENSPANG00000039561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167556"/>
    <dbReference type="OMA" id="DVKICTI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="145" mass="16798" checksum="2DC14F2CAC6D442B" modified="2022-05-25" version="1">FSSPTPQYLGFVCLFHFFETESRSVTQAGVQWPDLSSLQPQPPGFKRFFCLSLLSSWDYRCLPPLTQLIFFFFFFFFVFLVETEFHHIGQSSFEFLTSSDPPTSASQSARITGVSHRAQPHTYILQCRIFLSQYTVDELIKDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N4P4</accession>
    <name>A0A8I5N4P4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgin subfamily A member 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N4P4"/>
    <dbReference type="Ensembl" id="ENSPANT00000074297.1">
        <property type="protein sequence ID" value="ENSPANP00000048065.1"/>
        <property type="gene ID" value="ENSPANG00000016690.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000134"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF1">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="10">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="242" mass="27871" checksum="4EC6D1C915B4193C" modified="2022-05-25" version="1">MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVTLLLFSQKSLKIMKKASLLHIDAYTVIVAVKYLGAFIIQIVFRCTEAHSPESFKTGYSWYVHLQLTCQCSDWPTLKKNVENLYVLFLLSFLGMFLLYFPKCHSLLPPEFLPSLSSWLLAPELLISQLKMTRSQTSHLPILSVAPLSFQYHLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N5P6</accession>
    <name>A0A8I5N5P6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N5P6"/>
    <dbReference type="Ensembl" id="ENSPANT00000061693.1">
        <property type="protein sequence ID" value="ENSPANP00000048679.1"/>
        <property type="gene ID" value="ENSPANG00000044969.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00690000102286"/>
    <dbReference type="OMA" id="CRTSSWH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd09851">
        <property type="entry name" value="HTLV-1-like_HR1-HR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF73">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035235975" evidence="3">
        <location>
            <begin position="18"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="557" mass="62482" checksum="ECACB002C246A606" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N6I9</accession>
    <name>A0A8I5N6I9_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N6I9"/>
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        <property type="protein sequence ID" value="ENSPANP00000049123.1"/>
        <property type="gene ID" value="ENSPANG00000046444.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287003"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="303" mass="35842" checksum="A7BA05FD995CDE35" modified="2022-05-25" version="1">MAILPKVIYRFNAIPIKLPMSFFTELEKTALKFIWNQKRARISKTILSQKNKAGGITLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTESSEIIPHIYSHLIFDKPERNKKWGKDSLFNKWCWENWLTISRKMKLDPFLTPYTKINSRWIRDLNVRPNTIKILEENLGSTIQDIGMGKDFMSKTPKAMAAKAKIDKWDLIKLKSFCTAKETTIRVDRQPTEQEKIFAIYSSDKGLISRTCKELKQIDKKKNKQPHQKVGKGYEQTFLKRRHSYSQQTHEKMLIITGHQRNANQNHNEIPSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N6Z9</accession>
    <name>A0A8I5N6Z9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NDUFAF4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Binds calmodulin. Interacts with NDUFAF3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDUFAF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003897981.1">
        <property type="nucleotide sequence ID" value="XM_003897932.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N6Z9"/>
    <dbReference type="Ensembl" id="ENSPANT00000065632.1">
        <property type="protein sequence ID" value="ENSPANP00000053032.1"/>
        <property type="gene ID" value="ENSPANG00000038646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101021592"/>
    <dbReference type="KEGG" id="panu:101021592"/>
    <dbReference type="CTD" id="29078"/>
    <dbReference type="GeneTree" id="ENSGT00390000001627"/>
    <dbReference type="OMA" id="IPDQKYK"/>
    <dbReference type="OrthoDB" id="2434756at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="175" mass="20140" checksum="7E99D845716E1BB3" modified="2022-05-25" version="1">MGALVIRGIRNFNVENRAEREISKIKPSLAPRHPSTSNLLQEQISHYPEIKGEIARKDDKLLSFLKDVYVDSKDPVSSLQVKAAETCQEPKEFRLPKGHQFDMINMKSIPKGKISVVEALTLLNNHKLYPETWTAEKIVQEYQLEKKDVNSLLKYFVTFEVKIFTPEDKKAIQSK</sequence>
</entry>
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    <accession>A0A8I5N977</accession>
    <name>A0A8I5N977_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N977"/>
    <dbReference type="Ensembl" id="ENSPANT00000081962.1">
        <property type="protein sequence ID" value="ENSPANP00000054196.1"/>
        <property type="gene ID" value="ENSPANG00000041212.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000248489"/>
    <dbReference type="OMA" id="CSKAYQL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="53" mass="6428" checksum="976DC6B9DEFE59E6" modified="2022-05-25" version="1">MACINLHWEIIPSKKIIWESGQNVDYFLMLCSKAYQLKREYQYLPSLGFEKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NBG2</accession>
    <name>A0A8I5NBG2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NBG2"/>
    <dbReference type="Ensembl" id="ENSPANT00000079052.1">
        <property type="protein sequence ID" value="ENSPANP00000055408.1"/>
        <property type="gene ID" value="ENSPANG00000043465.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000199842"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035328892" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12382" checksum="522D0957026E1112" modified="2022-05-25" version="1">MPCHLSTTNFLFLFFFFFFLRRSLALSPRLECSGRISAHCKLRLPSLPPFSCFSLPSSWDYRRLPPHPASFLYFFSRDGVSLCSPGWSRSPDLVIRPSRPPKVLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NHZ0</accession>
    <name>A0A8I5NHZ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA excision repair protein ERCC-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent helicase ERCC6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cockayne syndrome protein CSB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ERCC6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPANT00000066211.1">
        <property type="protein sequence ID" value="ENSPANP00000058985.1"/>
        <property type="gene ID" value="ENSPANG00000022650.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158057"/>
    <dbReference type="OMA" id="CNITPCQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110016">
        <property type="term" value="C:B-WICH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097680">
        <property type="term" value="P:double-strand break repair via classical nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001033">
        <property type="term" value="P:negative regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006290">
        <property type="term" value="P:pyrimidine dimer repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010332">
        <property type="term" value="P:response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000303">
        <property type="term" value="P:response to superoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21397">
        <property type="entry name" value="cc_ERCC-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000863">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000018">
        <property type="entry name" value="Putative DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059240">
        <property type="entry name" value="cc_ERCC-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
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<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NMX6</accession>
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            <fullName evidence="3">Immunoglobulin V-set domain-containing protein</fullName>
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        <name type="scientific">Papio anubis</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
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                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
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                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
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                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="IgV_Light_Chain"/>
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        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
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            <begin position="1"/>
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            <begin position="38"/>
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    <accession>A0A8I5NRN7</accession>
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            <taxon>Cercopithecidae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
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                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
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                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
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                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
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                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
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                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031516312.1">
        <property type="nucleotide sequence ID" value="XM_031660452.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8I5NRN7"/>
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        <property type="protein sequence ID" value="ENSPANP00000059699.1"/>
        <property type="gene ID" value="ENSPANG00000043285.1"/>
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    <dbReference type="GeneID" id="100999750"/>
    <dbReference type="KEGG" id="panu:100999750"/>
    <dbReference type="GeneTree" id="ENSGT01150000286923"/>
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    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:olfactory receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="312" mass="35318" checksum="9F9DB8F6755A3BFF" modified="2022-05-25" version="1">MENYNQTSTDFILLGLFLPSRIGLLLFILIVLIFLMALFGNLSMILLIFLDTHLHTPMYFLLSQLSLIDLSYISTIVPKMASDFLYGNKSISFTGCGIQSFFFLALGGAEALLLASMAYDRYIAVCFPLHYLIRMSKRVCVLMITGSWIIGSINACAHTVYILHIPYCQSRAINHFFCDVPAMVTLACTDTWVYEGTVFLSTTIFLVFPFIGISCSYGRVLLAVYRMKSAEGRKKAYLTCSTHLTVVTFYYAPFVYTYLRPRSLRSPTEDKVLAVFYTILTPMLNPIIYSLRNKEVMGALTRVSQRLCSVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYN8</accession>
    <name>A0A8I5NYN8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSPANG00000042101.1"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183016"/>
    <dbReference type="OMA" id="CKELYTE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="498"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000059974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="703" mass="81514" checksum="810AA0579F50B688" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NYQ0</accession>
    <name>A0A8I5NYQ0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-1-gamma C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NYQ0"/>
    <dbReference type="Ensembl" id="ENSPANT00000079673.1">
        <property type="protein sequence ID" value="ENSPANP00000060423.1"/>
        <property type="gene ID" value="ENSPANG00000041580.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007552"/>
    <dbReference type="OMA" id="CLHLPFR"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="3">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000060423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="186" mass="21552" checksum="04F35CA4B3512705" modified="2022-05-25" version="1">MHHNKQATENAEEEVKLCERMAQFDAKTFAETQPKKDTPRKEKGLQEEKQKPQAERKEEPRTPSLTCPRGMFQRLDKLRKNDFASVILFGTNNSSSISGVWVFRGQELAFPLSPDWQVDYKSYTWWKLDPAARRPRRWFESTFPGRGPSSMWAKSSIRARSSSEHLLPLPSCLHLPFREMGVIKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R121</accession>
    <name>A0A8I5R121_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSPANP00000054841.1"/>
        <property type="gene ID" value="ENSPANG00000047051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="ENWIAMC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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        <property type="entry name" value="RT_dom"/>
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1275" mass="148851" checksum="FD796E1B390349FD" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R575</accession>
    <name>A0A8I5R575_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OR1C1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R575"/>
    <dbReference type="Ensembl" id="ENSPANT00000003105.3">
        <property type="protein sequence ID" value="ENSPANP00000048665.1"/>
        <property type="gene ID" value="ENSPANG00000011517.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164680"/>
    <dbReference type="OMA" id="ISFVNMD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15918">
        <property type="entry name" value="7tmA_OR1_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="319" mass="35588" checksum="71C3844B023DE618" modified="2022-05-25" version="1">MEKRNLTVVREFVLLGLPSSAEQQHLLSVLFLCMYLATTLGNMLIIVTIGFDSRLHSPMYFFLSNLAFIDICFTSTTVPQMVVNILTGTKTISFAGCLSQLFFFVTFVNMDSLLLCVMAYDRYVAICHPLHYTATMNLCLCVQLMAGLWLVTYLHALLHTVLTARLSFCASNIIHHFFCDLNPLLQLSCSDVSFNVMIIFAVGGLLAITPLVCILISYGIIFSTVLKITSTQGKQRAVSTCSCHLSVVVVFYGTAIAVYFSPSSSHTPESDSVSTIMYSVVAPMLNPFIYTIRNRDMKRGLQKMLFKCTVFQRNNDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R582</accession>
    <name>A0A8I5R582_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Matrin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031510232.1">
        <property type="nucleotide sequence ID" value="XM_031654372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5R582"/>
    <dbReference type="Ensembl" id="ENSPANT00000067974.1">
        <property type="protein sequence ID" value="ENSPANP00000048725.1"/>
        <property type="gene ID" value="ENSPANG00000037071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101025445"/>
    <dbReference type="GeneTree" id="ENSGT00940000153322"/>
    <dbReference type="OMA" id="CKGFVEL"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R5F6</accession>
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            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A8I5R7J4"/>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="Ankyrin repeat"/>
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    <feature type="repeat" description="ANK" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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        <source>
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        <source>
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            <dbReference type="Ensembl" id="ENSPANP00000054020.1"/>
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    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="834" mass="88419" checksum="74246A7FFC47F3EA" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5R8H2</accession>
    <name>A0A8I5R8H2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POU3F3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5R8H2"/>
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        <property type="gene ID" value="ENSPANG00000048187.1"/>
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        <property type="component" value="Chromosome 14"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071837">
        <property type="term" value="F:HMG box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021799">
        <property type="term" value="P:cerebral cortex radially oriented cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021869">
        <property type="term" value="P:forebrain ventricular zone progenitor cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072218">
        <property type="term" value="P:metanephric ascending thin limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072240">
        <property type="term" value="P:metanephric DCT cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072227">
        <property type="term" value="P:metanephric macula densa development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="POU DOMAIN"/>
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        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="225"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="317"/>
            <end position="376"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="101"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="142"/>
            <end position="230"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="411"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="57"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="92"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
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            <begin position="204"/>
            <end position="214"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="397"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010250"/>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023155"/>
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            <dbReference type="RuleBase" id="RU361194"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50071"/>
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            <dbReference type="PROSITE" id="PS51179"/>
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    <evidence type="ECO:0000313" key="14">
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            <dbReference type="Ensembl" id="ENSPANP00000056216.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
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            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="411" mass="42536" checksum="B894761FDB420570" modified="2022-05-25" version="1">MLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1986-07-21" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>P61629</accession>
    <accession>P00696</accession>
    <accession>P79163</accession>
    <accession>P79844</accession>
    <name>LYSC_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName>Lysozyme C</fullName>
            <ecNumber>3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>1,4-beta-N-acetylmuramidase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LYZ</name>
        <name type="synonym">LZM</name>
    </gene>
    <organism>
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Nature" volume="385" first="151" last="154">
            <title>Episodic adaptive evolution of primate lysozymes.</title>
            <authorList>
                <person name="Messier W."/>
                <person name="Stewart C.B."/>
            </authorList>
            <dbReference type="PubMed" id="8990116"/>
            <dbReference type="DOI" id="10.1038/385151a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Blood</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1973" name="J. Mol. Biol." volume="79" first="587" last="595">
            <title>Amino acid sequence of lysozyme from baboon milk.</title>
            <authorList>
                <person name="Hermann J."/>
                <person name="Jolles J."/>
                <person name="Buss D.H."/>
                <person name="Jolles P."/>
            </authorList>
            <dbReference type="PubMed" id="4202218"/>
            <dbReference type="DOI" id="10.1016/0022-2836(73)90408-7"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 19-148</scope>
        <source>
            <tissue>Milk</tissue>
        </source>
    </reference>
    <comment type="function">
        <text>Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text>Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Lysozyme C is capable of both hydrolysis and transglycosylation; it also shows a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17"/>
    <dbReference type="EMBL" id="U76919">
        <property type="protein sequence ID" value="AAB41207.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="A00850">
        <property type="entry name" value="LZBA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001106112.1">
        <property type="nucleotide sequence ID" value="NM_001112642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61629"/>
    <dbReference type="SMR" id="P61629"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012261"/>
    <dbReference type="CAZy" id="GH22">
        <property type="family name" value="Glycoside Hydrolase Family 22"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000067097.1">
        <property type="protein sequence ID" value="ENSPANP00000060558.1"/>
        <property type="gene ID" value="ENSPANG00000047975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100126730"/>
    <dbReference type="KEGG" id="panu:100126730"/>
    <dbReference type="CTD" id="4069"/>
    <dbReference type="eggNOG" id="ENOG502S1S1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153832"/>
    <dbReference type="HOGENOM" id="CLU_111620_0_1_1"/>
    <dbReference type="OrthoDB" id="17373at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000010682">
        <property type="expression patterns" value="Expressed in lung and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16897">
        <property type="entry name" value="LYZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000001">
        <property type="entry name" value="Lysozyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000974">
        <property type="entry name" value="Glyco_hydro_22_lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF28">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00137">
        <property type="entry name" value="LYSOZYME"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0929">Antimicrobial</keyword>
    <keyword id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018477" description="Lysozyme C">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lysozyme" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="3" ref="2">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="4202218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="148" mass="16409" checksum="41AE0FB34335ED6F" modified="2004-06-07" version="1" precursor="true">MKAVIILGLVLLSVTVQGKIFERCELARTLKRLGLDGYRGISLANWVCLAKWESDYNTQATNYNPGDQSTDYGIFQINSHYWCNNGKTPGAVNACHISCNALLQDNIADAVTCAKRVVSDPQGIRAWVAWRNHCQNRDVSQYVQGCGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q865Y1</accession>
    <name>IL2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName>Interleukin-2</fullName>
            <shortName>IL-2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>T-cell growth factor</fullName>
            <shortName>TCGF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IL2</name>
        <name type="synonym">IL-2</name>
    </gene>
    <organism>
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2003-02" db="EMBL/GenBank/DDBJ databases">
            <title>Nonhuman primate cytokines.</title>
            <authorList>
                <person name="Villinger F.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IL-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY234220">
        <property type="protein sequence ID" value="AAO85333.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001106124.1">
        <property type="nucleotide sequence ID" value="NM_001112654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q865Y1"/>
    <dbReference type="SMR" id="Q865Y1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003021"/>
    <dbReference type="GlyCosmos" id="Q865Y1">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="100126754"/>
    <dbReference type="KEGG" id="panu:100126754"/>
    <dbReference type="CTD" id="3558"/>
    <dbReference type="eggNOG" id="ENOG502RVR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9450228at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005134">
        <property type="term" value="F:interleukin-2 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045621">
        <property type="term" value="P:positive regulation of lymphocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000025">
        <property type="entry name" value="Interleukin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000779">
        <property type="entry name" value="IL-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030477">
        <property type="entry name" value="IL-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48487">
        <property type="entry name" value="INTERLEUKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48487:SF1">
        <property type="entry name" value="INTERLEUKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00715">
        <property type="entry name" value="IL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00265">
        <property type="entry name" value="INTERLEUKIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00189">
        <property type="entry name" value="IL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00424">
        <property type="entry name" value="INTERLEUKIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1064">Adaptive immunity</keyword>
    <keyword id="KW-0202">Cytokine</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0339">Growth factor</keyword>
    <keyword id="KW-0391">Immunity</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000015496" description="Interleukin-2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="O-linked (GalNAc...) threonine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P60568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="154" mass="17713" checksum="47F486BDF204AD6E" modified="2003-06-01" version="1" precursor="true">MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELRPLEEVLNLAQSKNFHLRDTKDLISNINVIVLELKGSETTLMCEYADETATIVEFLNRWITFCQSIISTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MKY8</accession>
    <name>A0A096MKY8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monocarboxylate transporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 16 member 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SLC16A7</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate. Dimerization is functionally required and both subunits work cooperatively in transporting substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71795"/>
            <dbReference type="ChEBI" id="CHEBI:10983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71871"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71783"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71779"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71775"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:64721"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:64722"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Interacts with GRID2IP. Interacts with EMB; interaction mediates SLC16A7 targeting to the plasma membrane. Interacts with isoform 2 of BSG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009179371.1">
        <property type="nucleotide sequence ID" value="XM_009181107.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009179372.1">
        <property type="nucleotide sequence ID" value="XM_009181108.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009179375.1">
        <property type="nucleotide sequence ID" value="XM_009181111.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009179376.1">
        <property type="nucleotide sequence ID" value="XM_009181112.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017801470.1">
        <property type="nucleotide sequence ID" value="XM_017945981.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021778236.1">
        <property type="nucleotide sequence ID" value="XM_021922544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MKY8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000177"/>
    <dbReference type="Ensembl" id="ENSPANT00000008849.4">
        <property type="protein sequence ID" value="ENSPANP00000000177.1"/>
        <property type="gene ID" value="ENSPANG00000022960.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101018838"/>
    <dbReference type="KEGG" id="panu:101018838"/>
    <dbReference type="CTD" id="9194"/>
    <dbReference type="GeneTree" id="ENSGT00940000157309"/>
    <dbReference type="HOGENOM" id="CLU_001265_59_1_1"/>
    <dbReference type="OMA" id="MGVAPMT"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000022960">
        <property type="expression patterns" value="Expressed in heart and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MKY8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17427">
        <property type="entry name" value="MFS_MCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000030">
        <property type="entry name" value="monocarboxylate transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004743">
        <property type="entry name" value="MCT"/>
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    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00892">
        <property type="entry name" value="2A0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF25">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="24">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="438"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="478" mass="52081" checksum="1AC3FEE4F00ECB45" modified="2014-11-26" version="1">MPPMPSTPPPHPPPDGGWGWVVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPISSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVIELYLTVGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPSQTTSKSKNKTVTTEDDSGQKKIKPKKSTWGKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSIMAFVDMFARPSVGLIANSKHIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAIFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTVVECGPVLLGPPLAGKLVDITGDYKYMYMACGAIVVAASVWLLIGNAINYRLLAKERKEQSARKTTRESERLSKSKHSEDVNVKVSNPPSVTSERETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MM91</accession>
    <name>A0A096MM91_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein 3A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FNDC3A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates spermatid-Sertoli adhesion during spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FNDC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MM91"/>
    <dbReference type="STRING" id="9555.ENSPANP00000000714"/>
    <dbReference type="Ensembl" id="ENSPANT00000025912.3">
        <property type="protein sequence ID" value="ENSPANP00000000714.2"/>
        <property type="gene ID" value="ENSPANG00000006006.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRT8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159319"/>
    <dbReference type="HOGENOM" id="CLU_004152_0_0_1"/>
    <dbReference type="OMA" id="GETEAMC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006006">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MM91">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000175">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000180">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000185">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000195">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000210">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000309">
        <property type="entry name" value="Fibronectin type III domain containing 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000366">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000337">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="286"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="391"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="487"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="584"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="682"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="779"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="879"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="969"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000000714.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133983" checksum="0495200B144CC4E3" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MNI4</accession>
    <name>A0A096MNI4_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cortexin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CTXN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031515873.1">
        <property type="nucleotide sequence ID" value="XM_031660013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MNI4"/>
    <dbReference type="SMR" id="A0A096MNI4"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001210"/>
    <dbReference type="Ensembl" id="ENSPANT00000017125.3">
        <property type="protein sequence ID" value="ENSPANP00000001210.2"/>
        <property type="gene ID" value="ENSPANG00000014766.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010749"/>
    <dbReference type="KEGG" id="panu:101010749"/>
    <dbReference type="CTD" id="404217"/>
    <dbReference type="eggNOG" id="ENOG502S3S8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154412"/>
    <dbReference type="HOGENOM" id="CLU_193122_0_0_1"/>
    <dbReference type="OMA" id="AWTPDYE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000014766">
        <property type="expression patterns" value="Expressed in amygdala and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020066">
        <property type="entry name" value="Cortexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16736:SF3">
        <property type="entry name" value="CORTEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16736">
        <property type="entry name" value="CORTEXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11057">
        <property type="entry name" value="Cortexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001210.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="82" mass="9045" checksum="BEEA6DBEDA10F0D3" modified="2018-02-28" version="2">MSATWTLSPEPLPPSTGPPVGAGLDAEQRTVFAFVLCLLVVLVLLMVRCVRILLDPYSRMPASSWTDHKEALERGQFDYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPL5</accession>
    <name>A0A096MPL5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARF like GTPase 14 effector protein like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARL14EPL</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003900064.1">
        <property type="nucleotide sequence ID" value="XM_003900015.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MPL5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001675"/>
    <dbReference type="Ensembl" id="ENSPANT00000028845.3">
        <property type="protein sequence ID" value="ENSPANP00000001675.1"/>
        <property type="gene ID" value="ENSPANG00000006470.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998615"/>
    <dbReference type="KEGG" id="panu:100998615"/>
    <dbReference type="CTD" id="644100"/>
    <dbReference type="eggNOG" id="KOG4850">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160347"/>
    <dbReference type="HOGENOM" id="CLU_105549_2_0_1"/>
    <dbReference type="OMA" id="WVYDDIV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000006470">
        <property type="expression patterns" value="Expressed in perirenal fat and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053130">
        <property type="entry name" value="ARL14_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46804">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR LIKE GTPASE 14 EFFECTOR PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46804:SF4">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001675.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="152" mass="17571" checksum="9641D4FAA3411EBA" modified="2014-11-26" version="1">MSEQSEKNNSIQEGHTDHSFPEKNCQIGQKQLQQIERQLKCLAFQNPGPQVADFNPETRQQKKKARMSKMNEYFSTKYKVMRKYDKSGRLLCNNVDLCDCLEKNCLGCFYPCPKCNSNKCGPECRCNRRWVYDAIVTESGEVISTLPFNVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MPZ7</accession>
    <name>A0A096MPZ7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cadherin-related family member 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Mu-protocadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CDHR5</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cell projection</location>
            <location evidence="14">Microvillus membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MPZ7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000001818"/>
    <dbReference type="Ensembl" id="ENSPANT00000014677.3">
        <property type="protein sequence ID" value="ENSPANP00000001818.3"/>
        <property type="gene ID" value="ENSPANG00000019483.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162463"/>
    <dbReference type="HOGENOM" id="CLU_021415_0_0_1"/>
    <dbReference type="OMA" id="PDYEANT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019483">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0090675">
        <property type="term" value="P:intermicrovillar adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032532">
        <property type="term" value="P:regulation of microvillus length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="2.60.40.60:FF:000261">
        <property type="entry name" value="Cadherin-related family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000292">
        <property type="entry name" value="Cadherin-related family member 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF243">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035288217" description="Cadherin-related family member 5" evidence="21">
        <location>
            <begin position="26"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="125"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="249"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="355"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="450"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="660"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="770"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001818.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="806" mass="83876" checksum="6B4B642363372497" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQG2</accession>
    <name>A0A096MQG2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein dispatched homolog 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Patched domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DISP3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003891158.2">
        <property type="nucleotide sequence ID" value="XM_003891109.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031520256.1">
        <property type="nucleotide sequence ID" value="XM_031664396.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000001989"/>
    <dbReference type="Ensembl" id="ENSPANT00000006347.3">
        <property type="protein sequence ID" value="ENSPANP00000001989.3"/>
        <property type="gene ID" value="ENSPANG00000015056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101016105"/>
    <dbReference type="KEGG" id="panu:101016105"/>
    <dbReference type="CTD" id="57540"/>
    <dbReference type="eggNOG" id="KOG3664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157931"/>
    <dbReference type="HOGENOM" id="CLU_007038_0_0_1"/>
    <dbReference type="OMA" id="RWDYSRT"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015056">
        <property type="expression patterns" value="Expressed in ventromedial nucleus of hypothalamus and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQG2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045834">
        <property type="term" value="P:positive regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000015">
        <property type="entry name" value="Dispatched RND transporter family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000022">
        <property type="entry name" value="Dispatched RND transporter family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042480">
        <property type="entry name" value="DISP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053954">
        <property type="entry name" value="DUF7023"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46687">
        <property type="entry name" value="PROTEIN DISPATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46687:SF1">
        <property type="entry name" value="PROTEIN DISPATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22894">
        <property type="entry name" value="DUF7023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="462"/>
            <end position="479"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="485"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="520"/>
            <end position="540"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="592"/>
            <end position="615"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="729"/>
            <end position="746"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1177"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1206"/>
            <end position="1227"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1288"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1320"/>
            <end position="1343"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1355"/>
            <end position="1377"/>
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    <feature type="domain" description="SSD" evidence="21">
        <location>
            <begin position="509"/>
            <end position="614"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="161"/>
            <end position="248"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053790"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067563"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074986"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000001989.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1391" mass="152801" checksum="9BD456FDED3EBC5A" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MQJ3</accession>
    <name>A0A096MQJ3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF596</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031525186.1">
        <property type="nucleotide sequence ID" value="XM_031669326.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031525187.1">
        <property type="nucleotide sequence ID" value="XM_031669327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MQJ3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002021"/>
    <dbReference type="Ensembl" id="ENSPANT00000009038.3">
        <property type="protein sequence ID" value="ENSPANP00000002021.3"/>
        <property type="gene ID" value="ENSPANG00000024623.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101013470"/>
    <dbReference type="CTD" id="169270"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154559"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024623">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MQJ3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000240">
        <property type="entry name" value="Zinc finger protein 250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001647">
        <property type="entry name" value="Zinc finger protein 596"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000430">
        <property type="entry name" value="zinc finger protein 596 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000830">
        <property type="entry name" value="zinc finger protein 596 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001740">
        <property type="entry name" value="zinc finger protein 596 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002250">
        <property type="entry name" value="zinc finger protein 596 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002015">
        <property type="entry name" value="ZNF596 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF96">
        <property type="entry name" value="GENE, 32687-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002021.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="504" mass="58455" checksum="9A0E947AFDCFA73D" modified="2022-05-25" version="3">MPSLDSMTFEDIVVDFTREEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSHLQQVEKLSTQGISLLQGREGDIKHQEIPFIQHTYQKGTSTISTMRSHTQEDPFLCNDLGEDFTEHTALTQNVITYMRKKHFVSKKFGKTFSDWLSFNQHNEIHTRCKSDEGHLFDYAFIQNSALRPHNVTHTRVITLECHVCGKTFSKNSNLRRHEMIHTGEKPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHLCGKAFSKSSNLRRHEMIHTREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCHLCGKAFSKCSYLRQHERTHNGEKPYECHLCGKAFSHCSHLRQHERSHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRHERTHTGEKPYECHLCGKAFNHSSVLRRHERTHTGEKPYECNICGKAFNRSYNFRLHKRVHTGEKPYVCPLCGKAFSKFFNLRQHERTHTKKVMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MRU3</accession>
    <name>A0A096MRU3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIT domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MITD1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003909068.2">
        <property type="nucleotide sequence ID" value="XM_003909019.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MRU3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000002500"/>
    <dbReference type="Ensembl" id="ENSPANT00000027708.3">
        <property type="protein sequence ID" value="ENSPANP00000002500.3"/>
        <property type="gene ID" value="ENSPANG00000016224.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015880"/>
    <dbReference type="KEGG" id="panu:101015880"/>
    <dbReference type="CTD" id="129531"/>
    <dbReference type="eggNOG" id="KOG4509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010868"/>
    <dbReference type="HOGENOM" id="CLU_088713_1_0_1"/>
    <dbReference type="OMA" id="FYKASNP"/>
    <dbReference type="OrthoDB" id="19553at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016224">
        <property type="expression patterns" value="Expressed in axillary lymph node and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MRU3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02683">
        <property type="entry name" value="MIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02685">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000021">
        <property type="entry name" value="MIT domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.30:FF:000001">
        <property type="entry name" value="MIT domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045331">
        <property type="entry name" value="MITD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="10">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000002500.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="274" mass="32066" checksum="D150D907F6764666" modified="2022-05-25" version="3">MTASRKRSRPASLQPGLRWRKIPGIMAKSGLGQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKEHLEQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGTEQVQQSRGLQEIEESLRSHGVLLEVRYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MTV0</accession>
    <name>A0A096MTV0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Growth factor receptor-bound protein 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GRB14 adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GRB14</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRB7/10/14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003907599.1">
        <property type="nucleotide sequence ID" value="XM_003907550.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MTV0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000003243"/>
    <dbReference type="Ensembl" id="ENSPANT00000021535.3">
        <property type="protein sequence ID" value="ENSPANP00000003243.2"/>
        <property type="gene ID" value="ENSPANG00000008395.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998087"/>
    <dbReference type="KEGG" id="panu:100998087"/>
    <dbReference type="CTD" id="2888"/>
    <dbReference type="eggNOG" id="KOG3751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158609"/>
    <dbReference type="HOGENOM" id="CLU_023207_0_1_1"/>
    <dbReference type="OrthoDB" id="5990423at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008395">
        <property type="expression patterns" value="Expressed in pancreas and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MTV0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16139">
        <property type="entry name" value="RA_GRB14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10414">
        <property type="entry name" value="SH2_Grb14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000015">
        <property type="entry name" value="Growth factor receptor-bound protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000714">
        <property type="entry name" value="Growth factor receptor-bound protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000133">
        <property type="entry name" value="growth factor receptor-bound protein 14 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015042">
        <property type="entry name" value="BPS-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035034">
        <property type="entry name" value="Grb14_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF22">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08947">
        <property type="entry name" value="BPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Ras-associating" evidence="17">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="234"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="439"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003243.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="540" mass="60843" checksum="0B4BEB236475ACD1" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MUN1</accession>
    <name>A0A096MUN1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRELI domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PRELID2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A096MUN1"/>
    <dbReference type="Ensembl" id="ENSPANT00000017875.3">
        <property type="protein sequence ID" value="ENSPANP00000003547.2"/>
        <property type="gene ID" value="ENSPANG00000008877.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RYVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182810"/>
    <dbReference type="HOGENOM" id="CLU_067902_6_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000008877">
        <property type="expression patterns" value="Expressed in descending colon and 62 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MUN1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266062" evidence="2">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PRELI/MSF1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000003547.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="276" mass="31876" checksum="A6D9220E12893417" modified="2022-05-25" version="2">MATILTICIVSPAFVNTVLQVFHGTSHPQKLTQEPCSISREANRVLEKPLPIIDFGKIIIYTNNLKIIRTPMDKRDFVRKILQKEEEAEEESLMNKEESYGGRDQQDRPLVEAESTFPHNRYTQYPNPMDKNVLSVKITEEKRDESTGVIYRKRIAICQNVVPEILRKVSILKVPNIQLEEESWLNPRERNMAIRSHCLTWTQYASMKEESVFRESMENPNWTEFIQRGRISITGAGFLNCILETFASTFLRQGAQKGIRIMEMLLKEQCGAPIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MVZ2</accession>
    <name>A0A096MVZ2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase complex assembly factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NDUFAF2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899758.2">
        <property type="nucleotide sequence ID" value="XM_003899709.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MVZ2"/>
    <dbReference type="SMR" id="A0A096MVZ2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004033"/>
    <dbReference type="Ensembl" id="ENSPANT00000018498.3">
        <property type="protein sequence ID" value="ENSPANP00000004033.1"/>
        <property type="gene ID" value="ENSPANG00000011811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101013581"/>
    <dbReference type="KEGG" id="panu:101013581"/>
    <dbReference type="CTD" id="91942"/>
    <dbReference type="eggNOG" id="ENOG502S21I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002743"/>
    <dbReference type="HOGENOM" id="CLU_138027_0_0_1"/>
    <dbReference type="OMA" id="HKTWAGQ"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011811">
        <property type="expression patterns" value="Expressed in dorsal thalamus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MVZ2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061179">
        <property type="term" value="P:negative regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="169" mass="19675" checksum="FB772C00C89473A2" modified="2014-11-26" version="1">MGWSQDLFRALWRSLSREVKEHVGTDQFGNKYYCIPQYKNWRGQTIREKRIVEGANKKEVDYEIGDIPTEWEAWIRRTRKTPPTMEEIVKNEKYREEVKIKSQDFCEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQPGSWVPQDGKSHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MWC1</accession>
    <name>A0A096MWC1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA damage inducible 1 homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DDI2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009197845.1">
        <property type="nucleotide sequence ID" value="XM_009199581.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MWC1"/>
    <dbReference type="Ensembl" id="ENSPANT00000020542.3">
        <property type="protein sequence ID" value="ENSPANP00000004177.2"/>
        <property type="gene ID" value="ENSPANG00000015838.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101011468"/>
    <dbReference type="CTD" id="84301"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182999"/>
    <dbReference type="HOGENOM" id="CLU_020435_1_0_1"/>
    <dbReference type="OMA" id="GHRLNAF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015838">
        <property type="expression patterns" value="Expressed in bone marrow and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MWC1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072711">
        <property type="term" value="P:cellular response to hydroxyurea"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097752">
        <property type="term" value="P:regulation of DNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000005">
        <property type="entry name" value="DNA damage inducible 1 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000107">
        <property type="entry name" value="protein DDI1 homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004177.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="399" mass="44465" checksum="C2DFCA9E735CD1D9" modified="2018-02-28" version="2">MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPPVQFPNLPRIDFSSIAVPGTSSPRQRQPPGTQQSHSSPGEITSSPQGLDNPALLRGMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGAGREDVRPEEIADQELAEALQKSAEDAERQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MX21</accession>
    <name>A0A096MX21_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRPF38B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003892351.2">
        <property type="nucleotide sequence ID" value="XM_003892302.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MX21"/>
    <dbReference type="STRING" id="9555.ENSPANP00000004431"/>
    <dbReference type="Ensembl" id="ENSPANT00000002332.3">
        <property type="protein sequence ID" value="ENSPANP00000004431.2"/>
        <property type="gene ID" value="ENSPANG00000007560.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026971"/>
    <dbReference type="KEGG" id="panu:101026971"/>
    <dbReference type="CTD" id="55119"/>
    <dbReference type="eggNOG" id="KOG2888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287057"/>
    <dbReference type="HOGENOM" id="CLU_034151_1_2_1"/>
    <dbReference type="OMA" id="ERSHKHD"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007560">
        <property type="expression patterns" value="Expressed in axillary lymph node and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096MX21">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000004431.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="547" mass="64412" checksum="230ECD1056E599B9" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MYH2</accession>
    <name>A0A096MYH2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">F2R like trypsin receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">F2RL1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with PPP1CC isoform gamma-2; the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096MZB6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000005312"/>
    <dbReference type="Ensembl" id="ENSPANT00000015827.3">
        <property type="protein sequence ID" value="ENSPANP00000005312.3"/>
        <property type="gene ID" value="ENSPANG00000024380.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158260"/>
    <dbReference type="HOGENOM" id="CLU_062444_0_0_1"/>
    <dbReference type="OMA" id="RRFLMNW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024380">
        <property type="expression patterns" value="Expressed in paraventricular nucleus of thalamus and 38 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21340">
        <property type="entry name" value="PPP1R42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000201">
        <property type="entry name" value="protein phosphatase 1 regulatory subunit 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000293">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005312.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="310" mass="35681" checksum="3B66BC77E6A57A53" modified="2022-05-25" version="3">MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLQSLAKSLSILNISNNNIDDIRDLEILENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSSKNEDASNSLISNFETMHHIVPVYYPQVGKPKLVFFSEIQRYPVNGNASPESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096MZJ4</accession>
    <name>A0A096MZJ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 182</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Zinc finger protein 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF182</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003917697.1">
        <property type="nucleotide sequence ID" value="XM_003917648.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195768.1">
        <property type="nucleotide sequence ID" value="XM_009197504.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195769.1">
        <property type="nucleotide sequence ID" value="XM_009197505.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009195770.1">
        <property type="nucleotide sequence ID" value="XM_009197506.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096MZJ4"/>
    <dbReference type="Ensembl" id="ENSPANT00000000716.3">
        <property type="protein sequence ID" value="ENSPANP00000005396.1"/>
        <property type="gene ID" value="ENSPANG00000005277.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101024687"/>
    <dbReference type="KEGG" id="panu:101024687"/>
    <dbReference type="CTD" id="7569"/>
    <dbReference type="GeneTree" id="ENSGT00940000162614"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005277">
        <property type="expression patterns" value="Expressed in pancreas and 65 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline"/>
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        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0009891">
        <property type="term" value="P:positive regulation of biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001073">
        <property type="entry name" value="zinc finger protein 182"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000053">
        <property type="entry name" value="zinc finger protein 182 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000824">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 26 isoform X3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
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    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
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    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
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    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="299"/>
            <end position="326"/>
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    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="327"/>
            <end position="354"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="551"/>
            <end position="578"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="579"/>
            <end position="606"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="599"/>
            <end position="620"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067441"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000005396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="620" mass="71660" checksum="625BA433FD93E2D6" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N217</accession>
    <name>A0A096N217_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ADAM metallopeptidase domain 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADAM32</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_021942239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N217"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006358"/>
    <dbReference type="Ensembl" id="ENSPANT00000022042.3">
        <property type="protein sequence ID" value="ENSPANP00000006358.3"/>
        <property type="gene ID" value="ENSPANG00000009844.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101006992"/>
    <dbReference type="KEGG" id="panu:101006992"/>
    <dbReference type="CTD" id="203102"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161015"/>
    <dbReference type="HOGENOM" id="CLU_012714_4_3_1"/>
    <dbReference type="OMA" id="GWQCLCP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009844">
        <property type="expression patterns" value="Expressed in testis and 39 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N217">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006508">
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        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
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        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
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        <property type="entry name" value="Disintegrin domain"/>
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        <property type="entry name" value="ADAM_Cys-rich"/>
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        <property type="entry name" value="Disintegrin_dom"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Peptidase_M12B_N"/>
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        <property type="entry name" value="Reprolysin_adamalysin"/>
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    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
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        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 32"/>
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        <property type="entry name" value="Pep_M12B_propep"/>
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        <property type="entry name" value="Reprolysin"/>
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        <property type="entry name" value="DISIN"/>
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        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
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    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="12">
        <location>
            <begin position="219"/>
            <end position="416"/>
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    </feature>
    <feature type="domain" description="Disintegrin" evidence="11">
        <location>
            <begin position="424"/>
            <end position="512"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="752"/>
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        <location>
            <begin position="762"/>
            <end position="781"/>
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        <location>
            <begin position="805"/>
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        <location>
            <begin position="372"/>
            <end position="377"/>
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    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="678"/>
            <end position="687"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50215"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006358.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="821" mass="91816" checksum="4B8F2B8258D0147F" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N5L5</accession>
    <name>A0A096N5L5_PAPAN</name>
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        <submittedName>
            <fullName evidence="4">Testis expressed 15, meiosis and synapsis associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TEX15</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_021942185.2"/>
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    <dbReference type="RefSeq" id="XP_031525324.1">
        <property type="nucleotide sequence ID" value="XM_031669464.1"/>
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    <dbReference type="RefSeq" id="XP_031525325.1">
        <property type="nucleotide sequence ID" value="XM_031669465.1"/>
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    <dbReference type="RefSeq" id="XP_031525326.1">
        <property type="nucleotide sequence ID" value="XM_031669466.1"/>
    </dbReference>
    <dbReference type="STRING" id="9555.ENSPANP00000007728"/>
    <dbReference type="Ensembl" id="ENSPANT00000016092.3">
        <property type="protein sequence ID" value="ENSPANP00000007728.3"/>
        <property type="gene ID" value="ENSPANG00000026090.3"/>
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    <dbReference type="CTD" id="56154"/>
    <dbReference type="eggNOG" id="ENOG502QW6W">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000006260"/>
    <dbReference type="HOGENOM" id="CLU_000620_0_0_1"/>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="Bgee" id="ENSPANG00000026090">
        <property type="expression patterns" value="Expressed in testis and 6 other cell types or tissues"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TASOR_DUF3715"/>
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        <property type="entry name" value="TEX15_dom"/>
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    <dbReference type="PANTHER" id="PTHR22380:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 15"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF3715"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADP-ribosylation"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="103"/>
            <end position="250"/>
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            <begin position="1919"/>
            <end position="2150"/>
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    </feature>
    <feature type="domain" description="Testis expressed sequence 15" evidence="3">
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            <begin position="2364"/>
            <end position="2484"/>
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            <begin position="1"/>
            <end position="20"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="553"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="860"/>
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            <begin position="8"/>
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            <begin position="553"/>
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            <dbReference type="Pfam" id="PF15326"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="3177" mass="359990" checksum="D41645E96AC73D66" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N655</accession>
    <name>A0A096N655_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal protein S6 kinase beta-2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">70 kDa ribosomal protein S6 kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p70 ribosomal S6 kinase beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RPS6KB2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003909521.2">
        <property type="nucleotide sequence ID" value="XM_003909472.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N655"/>
    <dbReference type="STRING" id="9555.ENSPANP00000007942"/>
    <dbReference type="Ensembl" id="ENSPANT00000014731.3">
        <property type="protein sequence ID" value="ENSPANP00000007942.2"/>
        <property type="gene ID" value="ENSPANG00000011196.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101012071"/>
    <dbReference type="KEGG" id="panu:101012071"/>
    <dbReference type="CTD" id="6199"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155062"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="AGTHCIA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011196">
        <property type="expression patterns" value="Expressed in aorta and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N655">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000587">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001128">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="69"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="331"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="409"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000007942.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="487" mass="54057" checksum="93985FC8C54B1B75" modified="2022-05-25" version="2">MAAVFDLDLETEEGSEGEGEGEPELSSADVCPFAELRAAGLEPVGHYEEVELTETSVNLCPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFMHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLARRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPISPLKFSPFEGFRPSPSLPEPMEPPLPPLLPPPPPPPPSITAPLPIRPPSGTKKSKRGRGRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096N8D3</accession>
    <name>A0A096N8D3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial fission regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MTFR1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MTFR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003902860.2">
        <property type="nucleotide sequence ID" value="XM_003902811.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017817553.1">
        <property type="nucleotide sequence ID" value="XM_017962064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096N8D3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000008860"/>
    <dbReference type="Ensembl" id="ENSPANT00000016348.3">
        <property type="protein sequence ID" value="ENSPANP00000008860.1"/>
        <property type="gene ID" value="ENSPANG00000018058.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101023409"/>
    <dbReference type="KEGG" id="panu:101023409"/>
    <dbReference type="CTD" id="9650"/>
    <dbReference type="eggNOG" id="ENOG502QSSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183215"/>
    <dbReference type="HOGENOM" id="CLU_059135_0_0_1"/>
    <dbReference type="OMA" id="CPRIHFQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018058">
        <property type="expression patterns" value="Expressed in metanephros cortex and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096N8D3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF1">
        <property type="entry name" value="MITOCHONDRIAL FISSION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000008860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="333" mass="36919" checksum="54F42A8202036C5E" modified="2014-11-26" version="1">MLGWIKRLIRMVFHQVGVSMQSVLWSRKPYGSSRSIVRKIGTNLSLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRTEVRSRPPLQDDLLFFEKAPSRQISLPDLSQEEPQLKTPALANEEALQKICALENELAALRAQIAKIVTQQEQRNLIAGDLDSTTSGTTLPPPPPPPPPPPPPPLGLHQSVSAIDLIKERREKRANAGKTLVKNNPKKPEMPNMLEILKDMNSVKLRSVKRSEQDVKPKPVDATDPAALIAEALKKKFAYRYRSDSQDEAEKGVPKSESEATSERVLFGPHMLKPTGKMKALIENVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NA53</accession>
    <name>A0A096NA53_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NA53"/>
    <dbReference type="STRING" id="9555.ENSPANP00000009551"/>
    <dbReference type="Ensembl" id="ENSPANT00000001588.3">
        <property type="protein sequence ID" value="ENSPANP00000009551.2"/>
        <property type="gene ID" value="ENSPANG00000019164.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006922"/>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019164">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 56 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000009551.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="165" mass="17972" checksum="4D671167FC413B55" modified="2018-02-28" version="2">MPPKFDPNKIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITVKLTIQNRQAQTEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIINIARQMRHRSLARELSRTIKEILGTAQSVGCNVDGRHPYDIIDDINNGAVECPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096ND09</accession>
    <name>A0A096ND09_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 354B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF354B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009207952.1">
        <property type="nucleotide sequence ID" value="XM_009209688.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522535.1">
        <property type="nucleotide sequence ID" value="XM_031666675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096ND09"/>
    <dbReference type="STRING" id="9555.ENSPANP00000010732"/>
    <dbReference type="Ensembl" id="ENSPANT00000013424.3">
        <property type="protein sequence ID" value="ENSPANP00000010732.2"/>
        <property type="gene ID" value="ENSPANG00000002751.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010596"/>
    <dbReference type="KEGG" id="panu:101010596"/>
    <dbReference type="CTD" id="117608"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162570"/>
    <dbReference type="HOGENOM" id="CLU_002678_57_1_1"/>
    <dbReference type="OMA" id="FISEKSC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000013252">
        <property type="expression patterns" value="Expressed in perirenal fat and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000387">
        <property type="entry name" value="Zinc finger protein 354A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000579">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001387">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001586">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000011">
        <property type="entry name" value="zinc finger protein 615 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000416">
        <property type="entry name" value="zinc finger protein 879 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000485">
        <property type="entry name" value="Zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF54">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000010732.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="612" mass="70332" checksum="CC2E99D67CA40130" modified="2018-02-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NG78</accession>
    <name>A0A096NG78_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cystine/glutamate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amino acid transport system xc-</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 7 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">xCT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC7A11</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:70995"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-acetyl-L-cysteine(out) + L-glutamate(in) = N-acetyl-L-cysteine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:74567"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)</text>
            <dbReference type="Rhea" id="RHEA:71191"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc; this interaction mediates cell membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003899245.1">
        <property type="nucleotide sequence ID" value="XM_003899196.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NG78"/>
    <dbReference type="SMR" id="A0A096NG78"/>
    <dbReference type="STRING" id="9555.ENSPANP00000011945"/>
    <dbReference type="Ensembl" id="ENSPANT00000018882.3">
        <property type="protein sequence ID" value="ENSPANP00000011945.3"/>
        <property type="gene ID" value="ENSPANG00000004190.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101026194"/>
    <dbReference type="KEGG" id="panu:101026194"/>
    <dbReference type="CTD" id="23657"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160324"/>
    <dbReference type="HOGENOM" id="CLU_007946_3_0_1"/>
    <dbReference type="OMA" id="PHWVWVL"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004190">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 54 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097449">
        <property type="term" value="C:astrocyte projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015327">
        <property type="term" value="F:cystine:glutamate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140926">
        <property type="term" value="F:L-kynurenine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022840">
        <property type="term" value="F:leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140206">
        <property type="term" value="P:dipeptide import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090461">
        <property type="term" value="P:intracellular glutamate homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015811">
        <property type="term" value="P:L-cystine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098712">
        <property type="term" value="P:L-glutamate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048286">
        <property type="term" value="P:lung alveolus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035752">
        <property type="term" value="P:lysosomal lumen pH elevation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110076">
        <property type="term" value="P:negative regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904717">
        <property type="term" value="P:regulation of AMPA glutamate receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000211">
        <property type="term" value="P:regulation of glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903786">
        <property type="term" value="P:regulation of glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048021">
        <property type="term" value="P:regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033029">
        <property type="term" value="P:regulation of neutrophil apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051223">
        <property type="term" value="P:regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021756">
        <property type="term" value="P:striatum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000027">
        <property type="entry name" value="cystine/glutamate transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
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        <property type="entry name" value="L_AA_transporter"/>
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        <property type="entry name" value="2A0308"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CYSTINE_GLUTAMATE TRANSPORTER"/>
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        <property type="entry name" value="AA_permease_2"/>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="192"/>
            <end position="214"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="235"/>
            <end position="254"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="266"/>
            <end position="290"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="364"/>
            <end position="382"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="394"/>
            <end position="412"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="424"/>
            <end position="444"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="450"/>
            <end position="470"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050407"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051652"/>
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    <evidence type="ECO:0000256" key="14">
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            <dbReference type="ARBA" id="ARBA00051885"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="ARBA" id="ARBA00065438"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071314"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078584"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000011945.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="501" mass="55536" checksum="2FCBC727AFD5D13C" modified="2022-05-25" version="3">MVRKPVVSTISKGGYLQGNVNRRLPSLGNKEPPGQEKVQLKRKVTLLRGISIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTSIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGLTVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFIITLTGVPAYYLFIIWDKKPKWFRIMSERITRTLQIILEVVPEEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NGU8</accession>
    <name>A0A096NGU8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein kinase cAMP-dependent type II regulatory subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PRKAR2B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003896505.2">
        <property type="nucleotide sequence ID" value="XM_003896456.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NGU8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012187"/>
    <dbReference type="Ensembl" id="ENSPANT00000005026.3">
        <property type="protein sequence ID" value="ENSPANP00000012187.3"/>
        <property type="gene ID" value="ENSPANG00000019819.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101018884"/>
    <dbReference type="KEGG" id="panu:101018884"/>
    <dbReference type="CTD" id="5577"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158160"/>
    <dbReference type="HOGENOM" id="CLU_018310_2_0_1"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019819">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043198">
        <property type="term" value="C:dendritic shaft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141162">
        <property type="term" value="P:negative regulation of cAMP/PKA signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12104">
        <property type="entry name" value="DD_RIIbeta_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000017">
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    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000002">
        <property type="entry name" value="cAMP-dependent protein kinase type II-alpha regulatory subunit"/>
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        <property type="entry name" value="Protein kinase cAMP-dependent type II regulatory subunit alpha"/>
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        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
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        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
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        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF156">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT"/>
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        <property type="entry name" value="CAMPKINASE"/>
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        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="cAMP-binding domain-like"/>
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        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
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        <property type="entry name" value="CNMP_BINDING_3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0114">cAMP</keyword>
    <keyword evidence="7 13" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
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        <ligand>
            <name>3',5'-cyclic AMP</name>
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        <ligand>
            <name>3',5'-cyclic AMP</name>
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            <label>2</label>
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        <location>
            <position position="364"/>
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        <ligand>
            <name>3',5'-cyclic AMP</name>
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            <label>2</label>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00037198"/>
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            <dbReference type="PIRSR" id="PIRSR000548-1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50042"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="421" mass="46514" checksum="B908EDBD0F8462DF" modified="2022-05-25" version="3">MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDAGASAAAAGGGTPSKGVNFAEEPMHSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTYDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NI50</accession>
    <name>A0A096NI50_PAPAN</name>
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        <recommendedName>
            <fullName evidence="1">Guanylyl cyclase-activating protein 2</fullName>
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        <alternativeName>
            <fullName evidence="9">Guanylate cyclase activator 1B</fullName>
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        <name evidence="11" type="primary">GUCA1B</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <property type="term" value="C:cone photoreceptor outer segment"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012648.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="200" mass="23420" checksum="79B898868BA35768" modified="2022-05-25" version="3">MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEGIYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMNPSSWLAQQRRKSAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIM5</accession>
    <name>A0A096NIM5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable inactive allantoicase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ALLC</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003908282.1">
        <property type="nucleotide sequence ID" value="XM_003908233.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NIM5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012823"/>
    <dbReference type="Ensembl" id="ENSPANT00000016606.3">
        <property type="protein sequence ID" value="ENSPANP00000012823.1"/>
        <property type="gene ID" value="ENSPANG00000017775.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101007603"/>
    <dbReference type="KEGG" id="panu:101007603"/>
    <dbReference type="CTD" id="55821"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001793"/>
    <dbReference type="HOGENOM" id="CLU_038797_1_2_1"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017775">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000085">
        <property type="entry name" value="probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="223"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="410" mass="45787" checksum="CC52E7D99A13F86E" modified="2014-11-26" version="1">MADAPKEGRLTRFLDFTQLTDMASESVGGKILFATDDFFAPAENLIKSDSPCFKEREYTEFGKWMDGWETRRKRIPGHDWCVLRLGIQGVIRAFDVDVSYFTGDYAPRMSIQAANLEEEKLPEIPERGIRTGAAATPEEFEAIAELKSDDWSYLVPMTELKPGNPASGHNYFLVNSQQRWTHIRLNIFPDGGIARLRVLGTGQKDWTATDPKEHADLVAIAFGGVCVGFSSAKFGHPNNIIGVGGAKSMADGWETARRLDRPPILENDDNGILLVSGCEWAVFRLAHPGVITRIEIDTKYFKGNAPDSCKVDGCVLTTQEEEDMIKQKWILPAHKWKPLLPVTKLSPNQSHLFDSLTLELQDVITHARLTIVPDGGVSRLRLRGFPSSICLLRPREKPMMKFSVGFKANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NIM7</accession>
    <name>A0A096NIM7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Doublecortin domain-containing protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DCDC2C</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NIM7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000012825"/>
    <dbReference type="Ensembl" id="ENSPANT00000022644.3">
        <property type="protein sequence ID" value="ENSPANP00000012825.3"/>
        <property type="gene ID" value="ENSPANG00000007153.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162396"/>
    <dbReference type="HOGENOM" id="CLU_035041_0_0_1"/>
    <dbReference type="OMA" id="CKYDGIP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000007153">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17151">
        <property type="entry name" value="DCX1_DCDC2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000012">
        <property type="entry name" value="Doublecortin domain containing 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000015">
        <property type="entry name" value="Doublecortin domain containing 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF9">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Doublecortin" evidence="10">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="10">
        <location>
            <begin position="136"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000012825.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="419" mass="47481" checksum="46E903DDE97FB5EA" modified="2022-05-25" version="3">MGTRGPSALVDTTPAKTIVVYRNGDPFYVGKKFVLSRRRAATFEALLEQLTEQVDVPFGVRRLFTPTRGHRVLELDALQAGGKYVAAGRERFKELDYIHIVPRKPAKIRKLKEIKPVVHCDINVPSKWQTYHRISRHINVFTNGRLFIPPAKIIIPKFSLSDWDIVLATIGEKVFPLGGVRKLFTMNGHLLGDSKDLQDNHFYVAAGLETFKYFPYWKSPRVPSEVQQRYANVEKNSQRKKKVDSKGKEPCHYDDIPPKTQDSVYYAKEEKKKTLAEPLVQRGAGSGTFMETETKADGAKIEATTLNTLADANRKEGDVYKALTPSKETEGALDVKEDHHVQLEVPVDQRQAEIVKEDEEIHENTPDFEGNNDKEDARLCEDIERKVCINNKYCSFAFSTLKRDLTGESTDPQILSGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NJ97</accession>
    <name>A0A096NJ97_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin-16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Kidney-specific cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDH16</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003917051.1">
        <property type="nucleotide sequence ID" value="XM_003917002.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NJ97"/>
    <dbReference type="Ensembl" id="ENSPANT00000007673.3">
        <property type="protein sequence ID" value="ENSPANP00000013046.1"/>
        <property type="gene ID" value="ENSPANG00000015586.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101002591"/>
    <dbReference type="KEGG" id="panu:101002591"/>
    <dbReference type="CTD" id="1014"/>
    <dbReference type="GeneTree" id="ENSGT00940000161650"/>
    <dbReference type="HOGENOM" id="CLU_016170_1_0_1"/>
    <dbReference type="OrthoDB" id="8804268at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000015586">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NJ97">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000167">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000187">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000195">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000240">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000241">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000149">
        <property type="entry name" value="cadherin-16 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000159">
        <property type="entry name" value="cadherin-16 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF424">
        <property type="entry name" value="CADHERIN-16 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001929000" description="Cadherin-16" evidence="17">
        <location>
            <begin position="19"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="127"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="337"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="451"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="565"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="829" mass="90037" checksum="CDF43EFDF3D10F9F" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NJD6</accession>
    <name>A0A096NJD6_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP1B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009215305.1">
        <property type="nucleotide sequence ID" value="XM_009217041.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NJD6"/>
    <dbReference type="Ensembl" id="ENSPANT00000024326.3">
        <property type="protein sequence ID" value="ENSPANP00000013085.3"/>
        <property type="gene ID" value="ENSPANG00000011720.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101022493"/>
    <dbReference type="CTD" id="162"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155991"/>
    <dbReference type="HOGENOM" id="CLU_006320_1_1_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011720">
        <property type="expression patterns" value="Expressed in esophagus and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NJD6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="716"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="10">
        <location>
            <begin position="835"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013085.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="946" mass="104178" checksum="0726D35EBB566943" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NLV6</accession>
    <name>A0A096NLV6_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Immediate early response 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IER3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003897361.1">
        <property type="nucleotide sequence ID" value="XM_003897312.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NLV6"/>
    <dbReference type="STRING" id="9555.ENSPANP00000013964"/>
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        <property type="protein sequence ID" value="ENSPANP00000013964.1"/>
        <property type="gene ID" value="ENSPANG00000015956.3"/>
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    <dbReference type="GeneID" id="101000246"/>
    <dbReference type="KEGG" id="panu:101000246"/>
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    <dbReference type="eggNOG" id="ENOG502S3QE">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00390000003213"/>
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    <dbReference type="OrthoDB" id="9949267at2759"/>
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        <property type="component" value="Chromosome 6"/>
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    <dbReference type="Bgee" id="ENSPANG00000015956">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 43 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001562">
        <property type="term" value="P:response to protozoan"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="InterPro" id="IPR024829">
        <property type="entry name" value="IEX-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16915">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16915:SF0">
        <property type="entry name" value="RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02100">
        <property type="entry name" value="GENEIEX1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000013964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="156" mass="16998" checksum="FE2885045D7C370E" modified="2014-11-26" version="1">MCHSRSCHPTMTILQAPTPAPSTNPGPRRGSGPEIFTFDPLPEPAAVPAGRPSTSRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILIAEEGVPAPLPPEDAPSTASQAPTPVPPVLEPFNLTSEPSDYALDLSTFLQQHPAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQ26</accession>
    <name>A0A096NQ26_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interferon-inducible double-stranded RNA-dependent protein kinase activator A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein activator of the interferon-induced protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein kinase, interferon-inducible double-stranded RNA-dependent activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PRKRA</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRKRA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009180786.1">
        <property type="nucleotide sequence ID" value="XM_009182522.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQ26"/>
    <dbReference type="SMR" id="A0A096NQ26"/>
    <dbReference type="STRING" id="9555.ENSPANP00000015117"/>
    <dbReference type="Ensembl" id="ENSPANT00000022547.3">
        <property type="protein sequence ID" value="ENSPANP00000015117.1"/>
        <property type="gene ID" value="ENSPANG00000001046.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997154"/>
    <dbReference type="KEGG" id="panu:100997154"/>
    <dbReference type="CTD" id="8575"/>
    <dbReference type="eggNOG" id="KOG3732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157618"/>
    <dbReference type="HOGENOM" id="CLU_048292_0_0_1"/>
    <dbReference type="OMA" id="PEYEFEK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000001046">
        <property type="expression patterns" value="Expressed in abdominal segment muscle and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070883">
        <property type="term" value="F:pre-miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042474">
        <property type="term" value="P:middle ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042473">
        <property type="term" value="P:outer ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070922">
        <property type="term" value="P:RISC complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19889">
        <property type="entry name" value="DSRM_PRKRA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19891">
        <property type="entry name" value="DSRM_PRKRA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19892">
        <property type="entry name" value="DSRM_PRKRA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000005">
        <property type="entry name" value="Putative double-stranded RNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000019">
        <property type="entry name" value="RISC-loading complex subunit TARBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000018">
        <property type="entry name" value="RISC-loading complex subunit TARBP2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044465">
        <property type="entry name" value="PRKRA_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044466">
        <property type="entry name" value="PRKRA_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044467">
        <property type="entry name" value="PRKRA_DSRM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF2">
        <property type="entry name" value="INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="240"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="313" mass="34404" checksum="9B01637E6194827E" modified="2014-11-26" version="1">MSQSRHRAEAPPLEREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIDELSANGQYQCLAELSTSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NQN8</accession>
    <name>A0A096NQN8_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ceruloplasmin</fullName>
            <ecNumber evidence="13">1.11.1.27</ecNumber>
            <ecNumber evidence="4">1.11.1.9</ecNumber>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
            <ecNumber evidence="15">1.16.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Cuproxidase ceruloplasmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Ferroxidase ceruloplasmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Glutathione peroxidase ceruloplasmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Glutathione-dependent peroxiredoxin ceruloplasmin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">CP</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16834"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.16.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:30084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:11150"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:78539"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:78540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:62633"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Found in a complex with MPO and LTF; interacts directly with MPO and LTF, which allows Fe(3+) incorporation into LTF, activation of CP ferroxidase activity and protection of CP antioxidant properties by MPO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.27" evidence="13"/>
    <dbReference type="EC" id="1.11.1.9" evidence="4"/>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EC" id="1.16.3.4" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003895020.1">
        <property type="nucleotide sequence ID" value="XM_003894971.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NQN8"/>
    <dbReference type="Ensembl" id="ENSPANT00000028036.3">
        <property type="protein sequence ID" value="ENSPANP00000015350.1"/>
        <property type="gene ID" value="ENSPANG00000019531.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100998806"/>
    <dbReference type="KEGG" id="panu:100998806"/>
    <dbReference type="CTD" id="1356"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155866"/>
    <dbReference type="HOGENOM" id="CLU_005569_0_0_1"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000019531">
        <property type="expression patterns" value="Expressed in liver and 51 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NQN8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04222">
        <property type="entry name" value="CuRO_1_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11021">
        <property type="entry name" value="CuRO_2_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04224">
        <property type="entry name" value="CuRO_3_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11022">
        <property type="entry name" value="CuRO_4_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04225">
        <property type="entry name" value="CuRO_5_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11012">
        <property type="entry name" value="CuRO_6_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000009">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000015">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000037">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048236">
        <property type="entry name" value="Ceruloplasmin-like_CuRO_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF226">
        <property type="entry name" value="CERULOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 27" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922116" description="Ceruloplasmin" evidence="27">
        <location>
            <begin position="20"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="30">
        <location>
            <begin position="92"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="222"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="30">
        <location>
            <begin position="807"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="29">
        <location>
            <begin position="956"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00072777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000015350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1065" mass="122359" checksum="383FEFC40C7B45D7" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NTN1</accession>
    <name>A0A096NTN1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinase</fullName>
            <ecNumber evidence="7">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ITPKA</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.127"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:11021"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003900858.1">
        <property type="nucleotide sequence ID" value="XM_003900809.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NTN1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016402"/>
    <dbReference type="Ensembl" id="ENSPANT00000010694.3">
        <property type="protein sequence ID" value="ENSPANP00000016402.1"/>
        <property type="gene ID" value="ENSPANG00000018852.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100997232"/>
    <dbReference type="KEGG" id="panu:100997232"/>
    <dbReference type="CTD" id="3706"/>
    <dbReference type="eggNOG" id="KOG1621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161350"/>
    <dbReference type="HOGENOM" id="CLU_017767_1_1_1"/>
    <dbReference type="OMA" id="FQVFVEF"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018852">
        <property type="expression patterns" value="Expressed in amygdala and 28 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF55">
        <property type="entry name" value="INOSITOL-TRISPHOSPHATE 3-KINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="461" mass="51022" checksum="C64C9CD17695075A" modified="2014-11-26" version="1">MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPARVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKSHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVEHDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NU45</accession>
    <name>A0A096NU45_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inactive carboxypeptidase-like protein X2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CPXM2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell-cell interactions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904423.3">
        <property type="nucleotide sequence ID" value="XM_003904374.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NU45"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016566"/>
    <dbReference type="MEROPS" id="M14.955"/>
    <dbReference type="Ensembl" id="ENSPANT00000026905.3">
        <property type="protein sequence ID" value="ENSPANP00000016566.3"/>
        <property type="gene ID" value="ENSPANG00000020354.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015972"/>
    <dbReference type="KEGG" id="panu:101015972"/>
    <dbReference type="CTD" id="119587"/>
    <dbReference type="eggNOG" id="KOG2649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156414"/>
    <dbReference type="HOGENOM" id="CLU_006722_4_0_1"/>
    <dbReference type="OMA" id="QHGKGIP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020354">
        <property type="expression patterns" value="Expressed in cornea and 58 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NU45">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03869">
        <property type="entry name" value="M14_CPX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000007">
        <property type="entry name" value="Carboxypeptidase X (M14 family), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000007">
        <property type="entry name" value="Carboxypeptidase X, M14 family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000035">
        <property type="entry name" value="probable carboxypeptidase X1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF45">
        <property type="entry name" value="INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035277599" description="Inactive carboxypeptidase-like protein X2" evidence="11">
        <location>
            <begin position="26"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="134"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="317"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016566.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="756" mass="85663" checksum="1BCFB7622DF4A4E4" modified="2022-05-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NUY9</accession>
    <name>A0A096NUY9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Thioredoxin-related transmembrane protein 1</fullName>
            <ecNumber evidence="5">5.3.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Protein disulfide-isomerase TMX1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thioredoxin domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">TMX1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with ATP2A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003901835.1">
        <property type="nucleotide sequence ID" value="XM_003901786.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NUY9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000016864"/>
    <dbReference type="Ensembl" id="ENSPANT00000013639.3">
        <property type="protein sequence ID" value="ENSPANP00000016864.1"/>
        <property type="gene ID" value="ENSPANG00000024493.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101009878"/>
    <dbReference type="KEGG" id="panu:101009878"/>
    <dbReference type="CTD" id="81542"/>
    <dbReference type="eggNOG" id="KOG0913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155959"/>
    <dbReference type="HOGENOM" id="CLU_069292_2_1_1"/>
    <dbReference type="OMA" id="FRQYKGS"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000024493">
        <property type="expression patterns" value="Expressed in testis and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090331">
        <property type="term" value="P:negative regulation of platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010868">
        <property type="term" value="P:negative regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051924">
        <property type="term" value="P:regulation of calcium ion transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02994">
        <property type="entry name" value="PDI_a_TMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000117">
        <property type="entry name" value="thioredoxin-related transmembrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF2">
        <property type="entry name" value="THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 27" id="KW-0732">Signal</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922274" description="Thioredoxin-related transmembrane protein 1" evidence="27">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="28">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004583"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062962"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072260"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00075863"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00076905"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000016864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="280" mass="31884" checksum="FCD7E44E0FD2C2E1" modified="2014-11-26" version="1">MAPSGSPALHLAVLVLLLWGAPWTHGRRSNVRVITDENWRELLEGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNVAKVDVTEQPGLSGRFIITALPTIYHCKDGEFRRYQGPRTKKDFINFISDKEWKSIEPVSSWFGPGSVLMSSMSALFQLSMWIRACHNYFIEDLGLPVWGSYTVFALATLFSGLLLGLCMIFVADCLCPSKRRRPQPYPYPSKKLLSESAQPLKKVEEEQEADEEDVSEEETERKEGTNKDFPQNAIRQRSLGPSLATDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NXF9</accession>
    <name>A0A096NXF9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Lipopolysaccharide-binding protein</fullName>
            <shortName evidence="10">LBP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LBP</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003904802.1">
        <property type="nucleotide sequence ID" value="XM_003904753.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096NXF9"/>
    <dbReference type="STRING" id="9555.ENSPANP00000017753"/>
    <dbReference type="Ensembl" id="ENSPANT00000007341.3">
        <property type="protein sequence ID" value="ENSPANP00000017753.1"/>
        <property type="gene ID" value="ENSPANG00000017516.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017759"/>
    <dbReference type="KEGG" id="panu:101017759"/>
    <dbReference type="CTD" id="3929"/>
    <dbReference type="eggNOG" id="KOG4160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286994"/>
    <dbReference type="HOGENOM" id="CLU_028970_3_2_1"/>
    <dbReference type="OMA" id="DPYMEID"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017516">
        <property type="expression patterns" value="Expressed in liver"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071723">
        <property type="term" value="F:lipopeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070891">
        <property type="term" value="F:lipoteichoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002752">
        <property type="term" value="P:cell surface pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071223">
        <property type="term" value="P:cellular response to lipoteichoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032490">
        <property type="term" value="P:detection of molecule of bacterial origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002232">
        <property type="term" value="P:leukocyte chemotaxis involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032757">
        <property type="term" value="P:positive regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043032">
        <property type="term" value="P:positive regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090023">
        <property type="term" value="P:positive regulation of neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060265">
        <property type="term" value="P:positive regulation of respiratory burst involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00026">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF66">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="10" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6 9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001922373" description="Lipopolysaccharide-binding protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="13">
        <location>
            <begin position="271"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000017753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="481" mass="53263" checksum="C536197BB80B1A43" modified="2014-11-26" version="1">MGALAGALPSILLALLLTSTPEALGANPGLVARTTDKGLEYAAQEGLLALQSELLRITLPDFTGDVRIPHAGRGSYEFRSLNIHSCELRHSALRPVPSQGLSLSISDSFIRVQGRWKVRKSFLKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIDDVEVDMSGDLGWLLNLFHNQIESKFQKVLKSRICEMIQKSVSSDLQPYLQTLPVTTEIDSFAGVDYSLVEAPRATAQMLEVMFKGEIFHRNHRSPVTLLAPVINLPEEHNKMVYFAVSDYVFNTASLVYHEEGYLNFSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPNMNLELQGSVPSAPLLNFSPGNLSVNPYMEIDAFVLLPSSSKEPVFRLTVATNVSAILTFNTSKITGFLQPGKVKVELKESKVGLFNAELLEALLNYYILNTLYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLFLGANVQYMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096NZW2</accession>
    <name>A0A096NZW2_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="24">STEAP4 metalloreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">STEAP4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:71773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:71769"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STEAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A096NZW2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000018637"/>
    <dbReference type="Ensembl" id="ENSPANT00000024424.3">
        <property type="protein sequence ID" value="ENSPANP00000018637.1"/>
        <property type="gene ID" value="ENSPANG00000021691.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008042"/>
    <dbReference type="HOGENOM" id="CLU_034618_1_1_1"/>
    <dbReference type="OMA" id="GWERNPK"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000021691">
        <property type="expression patterns" value="Expressed in bone marrow and 41 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096NZW2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008823">
        <property type="term" value="F:cupric reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070207">
        <property type="term" value="P:protein homotrimerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000051">
        <property type="entry name" value="STEAP2 metalloreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF5">
        <property type="entry name" value="METALLOREDUCTASE STEAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="23">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="22">
        <location>
            <begin position="359"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048958"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049387"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="569" mass="63715" checksum="E281E5FBA76B4FA7" modified="2014-11-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P025</accession>
    <name>A0A096P025_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPD1L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:11093"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="11"/>
    <dbReference type="RefSeq" id="XP_003895264.1">
        <property type="nucleotide sequence ID" value="XM_003895215.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A096P025"/>
    <dbReference type="Ensembl" id="ENSPANT00000019321.3">
        <property type="protein sequence ID" value="ENSPANP00000018700.3"/>
        <property type="gene ID" value="ENSPANG00000009800.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100997413"/>
    <dbReference type="KEGG" id="panu:100997413"/>
    <dbReference type="CTD" id="23171"/>
    <dbReference type="GeneTree" id="ENSGT00390000003114"/>
    <dbReference type="OMA" id="YDTPPMD"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009800">
        <property type="expression patterns" value="Expressed in gastrocnemius and 67 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A096P025">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000088">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000084">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF7">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="13">
        <location>
            <begin position="195"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000018700.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="351" mass="38387" checksum="74D6CC9FCB42F30D" modified="2022-05-25" version="3">MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLVDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-11-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A096P250</accession>
    <name>A0A096P250_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 120 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM120A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the constitutive coactivator of PPAR-gamma family.</text>
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        <property type="nucleotide sequence ID" value="XM_003911994.4"/>
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    <dbReference type="STRING" id="9555.ENSPANP00000019425"/>
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        <property type="protein sequence ID" value="ENSPANP00000019425.3"/>
        <property type="gene ID" value="ENSPANG00000024694.3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00530000063168"/>
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        <property type="component" value="Chromosome 13"/>
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    <dbReference type="Bgee" id="ENSPANG00000024694">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 67 other cell types or tissues"/>
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    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Constitutive coactivator of PPAR-gamma-like protein 1"/>
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    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026784">
        <property type="entry name" value="Coact_PPARg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR15976">
        <property type="entry name" value="CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15976:SF14">
        <property type="entry name" value="CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="571"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="993"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1158"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009495"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000019425.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
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    <accession>A0A096P3W7</accession>
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        <submittedName>
            <fullName evidence="4">Schlafen family member 12</fullName>
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        <name evidence="4" type="primary">SLFN12</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003912623.5"/>
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        <property type="nucleotide sequence ID" value="XM_009190124.4"/>
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        <property type="nucleotide sequence ID" value="XM_031657473.1"/>
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        <property type="gene ID" value="ENSPANG00000022996.3"/>
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    <dbReference type="GeneID" id="101016525"/>
    <dbReference type="KEGG" id="panu:101016525"/>
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    <dbReference type="GeneTree" id="ENSGT00410000025651"/>
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        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Bgee" id="ENSPANG00000022996">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="SLFN_GTPase-like"/>
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    <feature type="domain" description="Schlafen AlbA-2" evidence="1">
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            <begin position="200"/>
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    <feature type="domain" description="Schlafen GTPase-like" evidence="3">
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            <begin position="387"/>
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        <source>
            <dbReference type="Pfam" id="PF04326"/>
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        <source>
            <dbReference type="Pfam" id="PF17057"/>
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        <source>
            <dbReference type="Pfam" id="PF21026"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000020042.3"/>
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        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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</entry>
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        <name evidence="8" type="primary">NR2C2AP</name>
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            <taxon>Euteleostomi</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with NR2C2/TR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NR2C2AP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003915269.1">
        <property type="nucleotide sequence ID" value="XM_003915220.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MVC1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000006017"/>
    <dbReference type="Ensembl" id="ENSPANT00000021004.3">
        <property type="protein sequence ID" value="ENSPANP00000006017.3"/>
        <property type="gene ID" value="ENSPANG00000017708.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100999312"/>
    <dbReference type="KEGG" id="panu:100999312"/>
    <dbReference type="CTD" id="126382"/>
    <dbReference type="eggNOG" id="ENOG502RZAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017748"/>
    <dbReference type="HOGENOM" id="CLU_133965_0_0_1"/>
    <dbReference type="OMA" id="FFGRITV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017708">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000070">
        <property type="entry name" value="Nuclear receptor 2C2-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000006017.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="139" mass="15853" checksum="8AA42F992A1C7D12" modified="2022-05-25" version="3">MTHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQLIRVSQLQIQFQGGFSSRRGCLEGSQGSQALRKIADFYPEDNNSLQTFPIPAAEVDRLKVTFEDATDFFGRVVIYHLRVLGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MWC3</accession>
    <name>A0A0A0MWC3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mucolipin TRP cation channel 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MCOLN1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003914834.1">
        <property type="nucleotide sequence ID" value="XM_003914785.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0A0MWC3"/>
    <dbReference type="Ensembl" id="ENSPANT00000028532.3">
        <property type="protein sequence ID" value="ENSPANP00000009153.1"/>
        <property type="gene ID" value="ENSPANG00000011365.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101015107"/>
    <dbReference type="KEGG" id="panu:101015107"/>
    <dbReference type="CTD" id="57192"/>
    <dbReference type="eggNOG" id="KOG3733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183036"/>
    <dbReference type="HOGENOM" id="CLU_020945_1_1_1"/>
    <dbReference type="OMA" id="HHIKFRT"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000011365">
        <property type="expression patterns" value="Expressed in amygdala and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0A0MWC3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097682">
        <property type="term" value="F:intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005253">
        <property type="term" value="F:monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140367">
        <property type="term" value="P:antibacterial innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901660">
        <property type="term" value="P:calcium ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905673">
        <property type="term" value="P:positive regulation of lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
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            <begin position="496"/>
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    <feature type="domain" description="Mucolipin extracytosolic" evidence="18">
        <location>
            <begin position="91"/>
            <end position="285"/>
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    </feature>
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            <begin position="385"/>
            <end position="524"/>
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        <location>
            <begin position="1"/>
            <end position="38"/>
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</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0A0MX73</accession>
    <name>A0A0A0MX73_PAPAN</name>
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        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain 24</fullName>
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    <gene>
        <name evidence="7" type="primary">ANKRD24</name>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_017952090.3"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031508475.1">
        <property type="nucleotide sequence ID" value="XM_031652615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LGU8"/>
    <dbReference type="STRING" id="9555.ENSPANP00000022643"/>
    <dbReference type="Ensembl" id="ENSPANT00000042308.2">
        <property type="protein sequence ID" value="ENSPANP00000022643.2"/>
        <property type="gene ID" value="ENSPANG00000031836.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100997824"/>
    <dbReference type="KEGG" id="panu:100997824"/>
    <dbReference type="GeneTree" id="ENSGT00940000163209"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031836">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006721">
        <property type="term" value="P:terpenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20665">
        <property type="entry name" value="CYP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000299">
        <property type="entry name" value="Cytochrome P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF400">
        <property type="entry name" value="CYTOCHROME P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035202306" description="unspecific monooxygenase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000022643.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="490" mass="56099" checksum="EEAE180C5BD445F7" modified="2022-05-25" version="2">MDSLVVLVLCLSCLLLLSLWRQRSGRGKLPPGPTPLPVIGNILKIGIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPLFERANRRFGIVFSNGTRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKFNENAKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFVKSYILEKVKEHQESMDMNNPRDFIDCFLIKMEKEKHNQQSEFTIENLENAAVDLFAAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDVKFRNYLIPKGTTILISLTSVLRDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTSILQNFNLKSLVDLKDLDTTPVFNGFVSVPPVYQLCFVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LLG5</accession>
    <name>A0A2I3LLG5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="29">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ATP11C</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 29">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 28">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="25">Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11C and an accessory beta subunit TMEM30A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Membrane</location>
            <topology evidence="29">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 29">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="29"/>
    <dbReference type="RefSeq" id="XP_031516413.1">
        <property type="nucleotide sequence ID" value="XM_031660553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LLG5"/>
    <dbReference type="STRING" id="9555.ENSPANP00000024292"/>
    <dbReference type="Ensembl" id="ENSPANT00000035947.2">
        <property type="protein sequence ID" value="ENSPANP00000024292.2"/>
        <property type="gene ID" value="ENSPANG00000002237.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101020711"/>
    <dbReference type="CTD" id="286410"/>
    <dbReference type="GeneTree" id="ENSGT00940000158878"/>
    <dbReference type="OMA" id="EYNIAYN"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000002237">
        <property type="expression patterns" value="Expressed in liver and 60 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LLG5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000017">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000012">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF38">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 27 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="16 28 29" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 27 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 29" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1087"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="31">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="30">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="32">
        <location>
            <begin position="862"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="26">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00062576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000024292.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1149" mass="131670" checksum="39450CCE6543AC1A" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LPU9</accession>
    <name>A0A2I3LPU9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Spartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SPART</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with ITCH and WWP1. Interacts (via MIT domain) with IST1; leading to the recruitment of SPART to midbodies. Interacts with MAP1LC3A and MAP1LC3C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003913813.1">
        <property type="nucleotide sequence ID" value="XM_003913764.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003913814.1">
        <property type="nucleotide sequence ID" value="XM_003913765.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009190038.1">
        <property type="nucleotide sequence ID" value="XM_009191774.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009190039.1">
        <property type="nucleotide sequence ID" value="XM_009191775.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LPU9"/>
    <dbReference type="Ensembl" id="ENSPANT00000055611.2">
        <property type="protein sequence ID" value="ENSPANP00000025485.2"/>
        <property type="gene ID" value="ENSPANG00000018678.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101002679"/>
    <dbReference type="KEGG" id="panu:101002679"/>
    <dbReference type="CTD" id="23111"/>
    <dbReference type="GeneTree" id="ENSGT00390000012235"/>
    <dbReference type="OMA" id="WQGMECA"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018678">
        <property type="expression patterns" value="Expressed in optic disc and 65 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LPU9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048669">
        <property type="term" value="P:collateral sprouting in absence of injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048698">
        <property type="term" value="P:negative regulation of collateral sprouting in absence of injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050905">
        <property type="term" value="P:neuromuscular process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02679">
        <property type="entry name" value="MIT_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000009">
        <property type="entry name" value="spartin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MIT" evidence="19">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000025485.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="666" mass="72836" checksum="B0788F2BBA7A29ED" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LSV2</accession>
    <name>A0A2I3LSV2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LSV2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000026512"/>
    <dbReference type="Ensembl" id="ENSPANT00000031489.2">
        <property type="protein sequence ID" value="ENSPANP00000026512.1"/>
        <property type="gene ID" value="ENSPANG00000018990.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155478"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000018990">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LSV2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110158">
        <property type="term" value="C:calpain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16188">
        <property type="entry name" value="EFh_PEF_CPNS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000136">
        <property type="entry name" value="Calpain small subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF1">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000026512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="391" mass="41592" checksum="5B32095B56CD2303" modified="2018-02-28" version="1">MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEVRTPILGYGCLGGPYPLALHTSSELQSPPSYFASSPWVRAEGLVLWGSLSSLSTLLSPVAAADYVFLNWSPRLIPSPPRYRSHLEPRSLPGPILSAVTSLWGLLTHSFCSPSTCYPASQHPGPNMPAWSFPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LWA0</accession>
    <name>A0A2I3LWA0_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid phosphatase 5</fullName>
            <ecNumber evidence="7">3.1.3.4</ecNumber>
            <ecNumber evidence="15">3.6.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PLPP5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78229"/>
            <dbReference type="ChEBI" id="CHEBI:82765"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:42857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78229"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:42861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:39835"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:75757"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:39836"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27449"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:59996"/>
            <dbReference type="EC" id="3.6.1.75"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27450"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="7"/>
    <dbReference type="EC" id="3.6.1.75" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003902706.2">
        <property type="nucleotide sequence ID" value="XM_003902657.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3LWA0"/>
    <dbReference type="STRING" id="9555.ENSPANP00000027708"/>
    <dbReference type="Ensembl" id="ENSPANT00000053840.2">
        <property type="protein sequence ID" value="ENSPANP00000027708.2"/>
        <property type="gene ID" value="ENSPANG00000005870.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001445"/>
    <dbReference type="KEGG" id="panu:101001445"/>
    <dbReference type="CTD" id="84513"/>
    <dbReference type="GeneTree" id="ENSGT00940000159772"/>
    <dbReference type="OMA" id="CTPLIVI"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000005870">
        <property type="expression patterns" value="Expressed in pancreas and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LWA0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000810">
        <property type="term" value="F:diacylglycerol diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000022">
        <property type="entry name" value="Phospholipid phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF87">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="21">
        <location>
            <begin position="90"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000027708.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="266" mass="29638" checksum="79A273B9D8FB7FA4" modified="2022-05-25" version="2">MGKAAAAAAAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKPFQDKLALPTAQKKPGDSYCFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3LX98</accession>
    <name>A0A2I3LX98_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">JAG2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3LX98"/>
    <dbReference type="Ensembl" id="ENSPANT00000054336.2">
        <property type="protein sequence ID" value="ENSPANP00000028083.2"/>
        <property type="gene ID" value="ENSPANG00000016732.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160944"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000016732">
        <property type="expression patterns" value="Expressed in lateral hypothalamic nucleus and 46 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3LX98">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000007">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000148">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000310">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000431">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000445">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000473">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000824">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3510:FF:000006">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026219">
        <property type="entry name" value="Jagged/Serrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF35">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 17" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13 15 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 15 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0677">Repeat</keyword>
    <keyword evidence="17 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035216702" description="Delta-like protein" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="23">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="560"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="636"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="751"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="789"/>
            <end position="825"/>
        </location>
    </feature>
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        <location>
            <begin position="832"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1075"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1145"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="231"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="335"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="411"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="448"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="777"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000028083.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1200" mass="129295" checksum="9D1EB3547689BBE1" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3M916</accession>
    <name>A0A2I3M916_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 6 open reading frame 136</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C6orf136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3M916"/>
    <dbReference type="STRING" id="9555.ENSPANP00000032159"/>
    <dbReference type="Ensembl" id="ENSPANT00000045744.2">
        <property type="protein sequence ID" value="ENSPANP00000032159.1"/>
        <property type="gene ID" value="ENSPANG00000017650.3"/>
    </dbReference>
    <dbReference type="KEGG" id="panu:101026411"/>
    <dbReference type="GeneTree" id="ENSGT00390000008658"/>
    <dbReference type="OMA" id="PGALMPF"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000017650">
        <property type="expression patterns" value="Expressed in pons and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3M916">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000032159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="496" mass="54525" checksum="453596F2BCCF39A2" modified="2018-02-28" version="1">MYQPSRGAARRLGPCLRAYQARPQVSGAEAGGRRGGGERPSSEPVRGAERALGSAQAQRHPPPLPTCALQRVDGLGVAGAGGRRCRAWRVRTSVLPGLRADRRGQGQAAGRVCVAPDSPRLPVPRGDLKGRGGEIRSPAAAPSRSSSAQTRPAGRPQQPARLALGERSWQEGRPVSTRFGPLRRGWQDGHAPSRDGASGTPLGTEDQLYPGTLPFPPLWPHSTTTTSPSSPLLWSPLPPRLPTQRPPQVPPLPLPQIQALSSAWVVLPPGKGEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPGTAHPSPATPSGDPSMEEHLSVMYERLRQELPKLFLQSHDYSLYSLDVEFINEILNIRTKGRIWYILSLTLCRFLAWNYFTQLRLEVLQLTRHPENWTLQARWRLVGLPVHLLFLRFYKRDKDELYRTYDAYSTFYLNSSGLICRHRLDKLMPSHSPPTPVKKLLVGALVALGLSEPEPDLNLCSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MC55</accession>
    <name>A0A2I3MC55_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">26S proteasome non-ATPase regulatory subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSMD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.</text>
    </comment>
    <comment type="function">
        <text evidence="1 8">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L. Interacts with CRY1 in a KDM8-dependent manner. Interacts (via C-terminus) with phosphatase UBLCP1 (via ubiquitin-like domain); the interaction recruits UBLCP1 to the 19S regulatory particle where it dephosphorylates 19S subunit PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003894795.1">
        <property type="nucleotide sequence ID" value="XM_003894746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MC55"/>
    <dbReference type="SMR" id="A0A2I3MC55"/>
    <dbReference type="Ensembl" id="ENSPANT00000042000.2">
        <property type="protein sequence ID" value="ENSPANP00000033343.2"/>
        <property type="gene ID" value="ENSPANG00000009701.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101005799"/>
    <dbReference type="KEGG" id="panu:101005799"/>
    <dbReference type="CTD" id="5708"/>
    <dbReference type="GeneTree" id="ENSGT00940000153386"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000009701">
        <property type="expression patterns" value="Expressed in cornea and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MC55">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="11">
        <location>
            <begin position="853"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033343.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="908" mass="100210" checksum="C5DF0369C7624508" modified="2022-05-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MCA2</accession>
    <name>A0A2I3MCA2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transmembrane protease serine 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TMPRSS4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MCA2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000033387"/>
    <dbReference type="Ensembl" id="ENSPANT00000047331.2">
        <property type="protein sequence ID" value="ENSPANP00000033387.1"/>
        <property type="gene ID" value="ENSPANG00000004728.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230389"/>
    <dbReference type="OMA" id="GNWASAC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000004728">
        <property type="expression patterns" value="Expressed in cornea and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045967">
        <property type="term" value="P:negative regulation of growth rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046598">
        <property type="term" value="P:positive regulation of viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000046">
        <property type="entry name" value="Transmembrane protease serine 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000141">
        <property type="entry name" value="Transmembrane serine protease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="205"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000033387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="437" mass="48070" checksum="4FE855FED9B136E2" modified="2018-02-28" version="1">MLQDPDSDQPLNSLDVSPLRKPRTPMETFRKVGIPIIVALLSLASIIIVVVLIKVILDKYYFLCGQHLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVPVRLSKDRSTLQVLDPATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELHVRNSSGPCLSGSLVSLHCLACGESLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQLPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSIRCNADDAYQGEVTEKMVCAGIPEGGVDTCQGDSGGPLMYQSDQWQVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVRKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MJN3</accession>
    <name>A0A2I3MJN3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mucin catalytic TM and cytoplasmic tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MJN3"/>
    <dbReference type="STRING" id="9555.ENSPANP00000035922"/>
    <dbReference type="Ensembl" id="ENSPANT00000046478.2">
        <property type="protein sequence ID" value="ENSPANP00000035922.2"/>
        <property type="gene ID" value="ENSPANG00000031147.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164618"/>
    <dbReference type="OMA" id="MRRRYNG"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000031147">
        <property type="expression patterns" value="Expressed in esophagus and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028199">
        <property type="entry name" value="Mucin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14654">
        <property type="entry name" value="Epiglycanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Mucin catalytic TM and cytoplasmic tail" evidence="2">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000035922.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="112" mass="12052" checksum="4BAFD45E27142BD0" modified="2022-05-25" version="2">THTTSHRVITSASTAVSGAKPGGSLLPWEIFLITLVSVVAAVGLFAGLFFCVRNSLSLRNIFNTAVYRPHGLGPGPGGNRGAPHRPRWSPNWFWRRPVSSIAMEMSGRNNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MLK1</accession>
    <name>A0A2I3MLK1_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PNN</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003901784.2">
        <property type="nucleotide sequence ID" value="XM_003901735.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MLK1"/>
    <dbReference type="STRING" id="9555.ENSPANP00000036624"/>
    <dbReference type="Ensembl" id="ENSPANT00000038646.2">
        <property type="protein sequence ID" value="ENSPANP00000036624.1"/>
        <property type="gene ID" value="ENSPANG00000036062.2"/>
    </dbReference>
    <dbReference type="GeneID" id="101009877"/>
    <dbReference type="KEGG" id="panu:101009877"/>
    <dbReference type="CTD" id="5411"/>
    <dbReference type="GeneTree" id="ENSGT00730000111160"/>
    <dbReference type="OMA" id="FENRRTE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000036062">
        <property type="expression patterns" value="Expressed in axillary lymph node and 66 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006787">
        <property type="entry name" value="Pinin_SDK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04697">
        <property type="entry name" value="Pinin_SDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="14 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Pinin/SDK" evidence="24">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="23">
        <location>
            <begin position="136"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="279"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="576"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000036624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="717" mass="81625" checksum="21FE8581D9FE503F" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MUC3</accession>
    <name>A0A2I3MUC3_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A2I3MUC3"/>
    <dbReference type="Ensembl" id="ENSPANT00000059242.2">
        <property type="protein sequence ID" value="ENSPANP00000039353.2"/>
        <property type="gene ID" value="ENSPANG00000032888.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164691"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000032888">
        <property type="expression patterns" value="Expressed in thymus and 35 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF158">
        <property type="entry name" value="KRAB DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000039353.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="100" mass="11568" checksum="973AF0EDFEA78952" modified="2022-05-25" version="2">MCGMFWDSVAFEDVAVNFSQQEWALLDSSQKNLYREVMQETYRNLASVGKNGKTRILKITSKNLGKIQDNLHREEEIKSSEGILACHEFKNKQSKQIRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3MWC8</accession>
    <name>A0A2I3MWC8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 26 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC26A5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A2I3MWC8"/>
    <dbReference type="Ensembl" id="ENSPANT00000053788.2">
        <property type="protein sequence ID" value="ENSPANP00000039911.1"/>
        <property type="gene ID" value="ENSPANG00000012991.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286960"/>
    <dbReference type="OMA" id="YKDAQRV"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000012991">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3MWC8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120249">
        <property type="term" value="C:lateral wall of outer hair cell"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Akbar H.A."/>
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                <person name="Anosike U.A."/>
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                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
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                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
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                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
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                <person name="Munidasa M.M."/>
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                <person name="Nguyen N.N."/>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003904277.1">
        <property type="nucleotide sequence ID" value="XM_003904228.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3N6T2"/>
    <dbReference type="STRING" id="9555.ENSPANP00000043740"/>
    <dbReference type="Ensembl" id="ENSPANT00000054070.2">
        <property type="protein sequence ID" value="ENSPANP00000043740.1"/>
        <property type="gene ID" value="ENSPANG00000020883.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101010503"/>
    <dbReference type="KEGG" id="panu:101010503"/>
    <dbReference type="CTD" id="159686"/>
    <dbReference type="GeneTree" id="ENSGT00530000063534"/>
    <dbReference type="OMA" id="CQDDMRL"/>
    <dbReference type="OrthoDB" id="264785at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000020883">
        <property type="expression patterns" value="Expressed in postnatal subventricular zone and 34 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120229">
        <property type="term" value="P:protein localization to motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120317">
        <property type="term" value="P:sperm mitochondrial sheath assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF31">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="366"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="777"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000043740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="872" mass="103508" checksum="858420AAC6DEB81C" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I3NDX7</accession>
    <name>A0A2I3NDX7_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centrosomal protein of 57 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Translokin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CEP57</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translokin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003910628.1">
        <property type="nucleotide sequence ID" value="XM_003910579.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009185404.1">
        <property type="nucleotide sequence ID" value="XM_009187140.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I3NDX7"/>
    <dbReference type="STRING" id="9555.ENSPANP00000046112"/>
    <dbReference type="Ensembl" id="ENSPANT00000048921.2">
        <property type="protein sequence ID" value="ENSPANP00000046112.1"/>
        <property type="gene ID" value="ENSPANG00000003973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101017441"/>
    <dbReference type="KEGG" id="panu:101017441"/>
    <dbReference type="CTD" id="9702"/>
    <dbReference type="GeneTree" id="ENSGT00530000063695"/>
    <dbReference type="OMA" id="YMKQMIA"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSPANG00000003973">
        <property type="expression patterns" value="Expressed in testis and 64 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2I3NDX7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000003">
        <property type="entry name" value="Centrosomal protein of 57 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cep57_CLD"/>
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    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF11">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 57 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14073">
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="68"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="11">
        <location>
            <begin position="350"/>
            <end position="419"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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            <begin position="255"/>
            <end position="264"/>
        </location>
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            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
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            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00078763"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14073"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000046112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="499" mass="56712" checksum="A8D25D901ADA5FC2" modified="2018-02-28" version="1">MAAASVSAASGSQLSNILAEPSRSNGSVVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDLTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLTFEDKATPRVPSARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTSPSNGINEELAEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEEGNSSSRSGITGTTNKKDFTKLRPGEKGRKNLQLLKDMQTIQNSLQSSSLCWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MWS3</accession>
    <name>A0A8I5MWS3_PAPAN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSPANP00000049780.1"/>
        <property type="gene ID" value="ENSPANG00000049802.1"/>
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        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049780.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="109" mass="11608" checksum="09471E447362434C" modified="2022-05-25" version="1">MLECSGTVRAQCSLNLPGSSDPPTSASQVAGTTGMRHHAWLIFVFLVEMGFHQVGQAGLELLTSSDPPALAFQSAGITDVSHHAWTAFRTFQSESFESLIVNFQLGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MWY0</accession>
    <name>A0A8I5MWY0_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
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                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
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                <person name="Thornton R.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MWY0"/>
    <dbReference type="Ensembl" id="ENSPANT00000063330.1">
        <property type="protein sequence ID" value="ENSPANP00000049977.1"/>
        <property type="gene ID" value="ENSPANG00000038320.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="145" mass="16196" checksum="5E494C3F1DEA96C4" modified="2022-05-25" version="1">MESHSVAQAAVQWHDLSSLQPLSPGFKRFSCLSFLSTWGYRHAPPPSANFCIFSRHRVSSCWPGWSSLEVRSLKSRCWPGWFFLEASGENPLPCFFQLLEASTFLGSWPLLQIHQTSISITTSPTSDTKSPSAFLSSVITRDPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MYM7</accession>
    <name>A0A8I5MYM7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5MYM7"/>
    <dbReference type="Ensembl" id="ENSPANT00000063904.1">
        <property type="protein sequence ID" value="ENSPANP00000051238.1"/>
        <property type="gene ID" value="ENSPANG00000040529.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000186460"/>
    <dbReference type="OMA" id="PQRMGWA"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="114" mass="11397" checksum="261D946DECD8C23C" modified="2022-05-25" version="1">MSEQSKDLSDPNFAAEAPSSEVHSSPGVPEGVPPSETLAEPQSPPLGPTAAPQAAQPPQAPSDEDDPKALQQAAEEGPRSGTCSASWGCGPGRSTPPSGTCGSSSLRSSSSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZ36</accession>
    <name>A0A8I5MZ36_PAPAN</name>
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        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BORCS5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS5 family.</text>
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        <property type="nucleotide sequence ID" value="XM_017945676.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8I5MZ36"/>
    <dbReference type="SMR" id="A0A8I5MZ36"/>
    <dbReference type="Ensembl" id="ENSPANT00000062228.1">
        <property type="protein sequence ID" value="ENSPANP00000051606.1"/>
        <property type="gene ID" value="ENSPANG00000041834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100999607"/>
    <dbReference type="KEGG" id="panu:100999607"/>
    <dbReference type="CTD" id="118426"/>
    <dbReference type="GeneTree" id="ENSGT00390000015016"/>
    <dbReference type="OMA" id="EGRPHDP"/>
    <dbReference type="OrthoDB" id="10035640at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005873">
        <property type="term" value="C:plus-end kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903744">
        <property type="term" value="P:positive regulation of anterograde synaptic vesicle transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018780">
        <property type="entry name" value="TBORCS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634:SF2">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10158">
        <property type="entry name" value="LOH1CR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="196" mass="22220" checksum="D6FFE422E06F8EB8" modified="2022-05-25" version="1">MGSEQSSEAESRPNDLNSSVTPSPAKHRAKMDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGVDQTVPLLDRLNSLLPESERLEPFSMKPDRELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5MZ79</accession>
    <name>A0A8I5MZ79_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5MZ79"/>
    <dbReference type="Ensembl" id="ENSPANT00000071597.1">
        <property type="protein sequence ID" value="ENSPANP00000051690.1"/>
        <property type="gene ID" value="ENSPANG00000039893.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160356"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="160" mass="17306" checksum="FC1753EF27186AEB" modified="2022-05-25" version="1">MWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTTSPLVSWEVHGGGDSDPGSHPALILAAQPPPAPEGGGASWCPSTGCQSQMEAGPSGGGSSQVQAQPLAPFSFFFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N0A1</accession>
    <name>A0A8I5N0A1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ras homolog family member V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RHOV</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003900840.1">
        <property type="nucleotide sequence ID" value="XM_003900791.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N0A1"/>
    <dbReference type="Ensembl" id="ENSPANT00000062273.1">
        <property type="protein sequence ID" value="ENSPANP00000051183.1"/>
        <property type="gene ID" value="ENSPANG00000038427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101020571"/>
    <dbReference type="KEGG" id="panu:101020571"/>
    <dbReference type="CTD" id="171177"/>
    <dbReference type="GeneTree" id="ENSGT00940000157624"/>
    <dbReference type="OMA" id="TPELGIK"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04130">
        <property type="entry name" value="Wrch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000561">
        <property type="entry name" value="rho-related GTP-binding protein RhoV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="236" mass="26278" checksum="A45D28E8BFE3772F" modified="2022-05-25" version="1">MPPRELSEAEPPPLRTPTPPPRRRSAPQELGIKCVLVGDGAVGKSSLIVSYTCNGYPARYRPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N168</accession>
    <name>A0A8I5N168_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N168"/>
    <dbReference type="Ensembl" id="ENSPANT00000061641.1">
        <property type="protein sequence ID" value="ENSPANP00000052668.1"/>
        <property type="gene ID" value="ENSPANG00000039526.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="OMA" id="RMSHPAW"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="125" mass="14281" checksum="B7150E2BCB5E3F28" modified="2022-05-25" version="1">MQSGGDQIYSLIGIFFFFFFFFFFFETESRSVTQAGVQWPDLSSLQAPPPGFTPFSCLSLPSSWDYRRLPPRPAKFLYFFLVKTGFRHVGQAGLKLLTSSDLFALASQSTRVTRMSHPAWLHLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N1D8</accession>
    <name>A0A8I5N1D8_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A8I5N1D8"/>
    <dbReference type="Ensembl" id="ENSPANT00000083539.1">
        <property type="protein sequence ID" value="ENSPANP00000053059.1"/>
        <property type="gene ID" value="ENSPANG00000047135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="STWDERH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="120" mass="13213" checksum="D53A80CB30CD6651" modified="2022-05-25" version="1">MESCSVAQARVQWCNLSSLQPPPPGFKRFSCLGLLSTWDERHVPLHLTNFSILVEMGLHHVGQAGLELLTSGYLPASASQSAGITGLSHRARPEEVFKCCATSFFFPMRPMVFIVQFCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N242</accession>
    <name>A0A8I5N242_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vascular endothelial growth factor receptor 2</fullName>
            <ecNumber evidence="7">2.7.10.1</ecNumber>
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        <alternativeName>
            <fullName evidence="36">Fetal liver kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="37">Protein-tyrosine kinase receptor flk-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="48" type="primary">KDR</name>
    </gene>
    <organism evidence="48 49">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="48 49" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="48" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="48" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="catalytic activity">
        <reaction evidence="35 50">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
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            <dbReference type="EC" id="2.7.10.1"/>
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    <comment type="subcellular location">
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            <location evidence="4">Cell junction</location>
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        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
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        <subcellularLocation>
            <location evidence="5">Early endosome</location>
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        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
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        <subcellularLocation>
            <location evidence="42">Membrane</location>
            <topology evidence="42">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <text evidence="42">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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        <property type="entry name" value="Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
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        <property type="entry name" value="VEGFR-2_TMD"/>
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        <property type="entry name" value="VEGFR1-3_5th"/>
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        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
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        <property type="entry name" value="VEGFR2_rcpt"/>
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        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
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    <keyword evidence="34" id="KW-0968">Cytoplasmic vesicle</keyword>
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    <keyword evidence="20" id="KW-0418">Kinase</keyword>
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    <keyword evidence="27 44" id="KW-0472">Membrane</keyword>
    <keyword evidence="40" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 39 41" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30 42" id="KW-0675">Receptor</keyword>
    <keyword evidence="49" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="16 45" id="KW-0732">Signal</keyword>
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    <keyword evidence="26 44" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="28" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="24" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="45">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035259168" description="Vascular endothelial growth factor receptor 2" evidence="45">
        <location>
            <begin position="20"/>
            <end position="1356"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="44">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="47">
        <location>
            <begin position="224"/>
            <end position="320"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="47">
        <location>
            <begin position="328"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="47">
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            <begin position="421"/>
            <end position="548"/>
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    <feature type="domain" description="Ig-like" evidence="47">
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            <begin position="551"/>
            <end position="660"/>
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    <feature type="domain" description="Ig-like" evidence="47">
        <location>
            <begin position="667"/>
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    <feature type="domain" description="Protein kinase" evidence="46">
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            <begin position="834"/>
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    <feature type="region of interest" description="Disordered" evidence="43">
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            <begin position="1280"/>
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    </feature>
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        <location>
            <begin position="1296"/>
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            <position position="1028"/>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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        <source>
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    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00080196"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
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    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
            <dbReference type="RuleBase" id="RU000311"/>
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    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="46">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053256.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="49">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
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    </evidence>
    <sequence length="1356" mass="151474" checksum="6704B0286DEABEB1" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N310</accession>
    <name>A0A8I5N310_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prominin 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N310"/>
    <dbReference type="Ensembl" id="ENSPANT00000074751.1">
        <property type="protein sequence ID" value="ENSPANP00000052925.1"/>
        <property type="gene ID" value="ENSPANG00000041829.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000248373"/>
    <dbReference type="OMA" id="QWGSGRP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035175268" description="Prominin 2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000052925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="16807" checksum="413C7CDA3F7C0196" modified="2022-05-25" version="1">MRHALALLAPLLGLGLGLSLSQLAAGATDCKSLGPAEPLTFTPAARARWLAPRVRAPGLLDSLYGTVHRFLSAVQLNPFPSALPPLLVSLWTPAEARAGQWGSGRPSCPAACPGGAVRGGLRGVRRGRGPLPAADAHCRALLLLLPLPPALRGASEDRAQGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N519</accession>
    <name>A0A8I5N519_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N519"/>
    <dbReference type="Ensembl" id="ENSPANT00000081968.1">
        <property type="protein sequence ID" value="ENSPANP00000054221.1"/>
        <property type="gene ID" value="ENSPANG00000046478.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000285591"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000054221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="145" mass="15720" checksum="82AF023B93B8C514" modified="2022-05-25" version="1">MLPRLECSGTILTHCNVCLPDSSNSPALASQVAGTTGMSHRAQPTAPTFKITMNRPGAVAHACNPSTLGGRGRRIMRSGDRDHPGIQKISWAWWRAPVVPATREENGVNPGGGVCSELRSPHCTPAWVTEQDTVSKRKKKKDYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N5C4</accession>
    <name>A0A8I5N5C4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RMND5A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N5C4"/>
    <dbReference type="Ensembl" id="ENSPANT00000061537.1">
        <property type="protein sequence ID" value="ENSPANP00000051153.1"/>
        <property type="gene ID" value="ENSPANG00000005829.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153203"/>
    <dbReference type="OMA" id="LIRECKM"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16794">
        <property type="entry name" value="dRING_RMD5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
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    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
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    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
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    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037680">
        <property type="entry name" value="RMD5A_dRING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE RMND5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="522" mass="57372" checksum="018D5D33F3D31527" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7J7</accession>
    <name>A0A8I5N7J7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane spanning 4-domains A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MS4A12</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7J7"/>
    <dbReference type="Ensembl" id="ENSPANT00000074138.1">
        <property type="protein sequence ID" value="ENSPANP00000056556.1"/>
        <property type="gene ID" value="ENSPANG00000016979.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162443"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF72">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="223" mass="23390" checksum="A5DF5091307EA201" modified="2022-05-25" version="1">MVSSKPTSHAGVYETTPNPYYPPSSFTAPGSQQPPGSINLENQAQGAQSAQPYFITSPGTSAVSQPGQGNTQMINPSVGRAVINFKEEAKVLGFIISGSLSVSASKELSSCLVKGSLGMNIVSSIFAFIGVILLVVDMCINGIPNQDYSAVLSGQGISAMLMIFSLLEVCTACVTAYFANQANTTTNMPVLVIPNMYENNPVTPASSSAPPRCNNYSTNVPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7L5</accession>
    <name>A0A8I5N7L5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7L5"/>
    <dbReference type="Ensembl" id="ENSPANT00000067854.1">
        <property type="protein sequence ID" value="ENSPANP00000053368.1"/>
        <property type="gene ID" value="ENSPANG00000051082.1"/>
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    <dbReference type="GeneTree" id="ENSGT01100000263509"/>
    <dbReference type="OMA" id="KETFATH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
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    <dbReference type="FunFam" id="3.60.10.10:FF:000056">
        <property type="entry name" value="LINE-1 reverse transcriptase-like protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="498"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053368.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1275" mass="149192" checksum="E7BBD3150C446BEE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N7Z7</accession>
    <name>A0A8I5N7Z7_PAPAN</name>
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        <submittedName>
            <fullName evidence="22">Solute carrier family 8 member A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC8A3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_009210099.1">
        <property type="nucleotide sequence ID" value="XM_009211835.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017816776.1">
        <property type="nucleotide sequence ID" value="XM_017961287.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_017816777.1">
        <property type="nucleotide sequence ID" value="XM_017961288.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5N7Z7"/>
    <dbReference type="Ensembl" id="ENSPANT00000061291.1">
        <property type="protein sequence ID" value="ENSPANP00000053572.1"/>
        <property type="gene ID" value="ENSPANG00000007160.4"/>
    </dbReference>
    <dbReference type="GeneID" id="101014415"/>
    <dbReference type="CTD" id="6547"/>
    <dbReference type="GeneTree" id="ENSGT00940000157547"/>
    <dbReference type="OMA" id="VEMANYH"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:memory"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006851">
        <property type="term" value="P:mitochondrial calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098815">
        <property type="term" value="P:modulation of excitatory postsynaptic potential"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902532">
        <property type="term" value="P:negative regulation of intracellular signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048709">
        <property type="term" value="P:oligodendrocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014819">
        <property type="term" value="P:regulation of skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000001">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.1420.30:FF:000003">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.2030:FF:000001">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.2030:FF:000002">
        <property type="entry name" value="sodium/calcium exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CaCA"/>
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    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
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    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
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    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
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    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF7">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01699">
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    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0106">Calcium</keyword>
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    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
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    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
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            <end position="25"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="202"/>
            <end position="225"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="756"/>
            <end position="777"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="830"/>
            <end position="850"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="385"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="519"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000053572.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="928" mass="103189" checksum="06C9109F8FFB1A13" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N8G5</accession>
    <name>A0A8I5N8G5_PAPAN</name>
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        <recommendedName>
            <fullName evidence="5">Ral GTPase-activating protein subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">p170</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031512626.1">
        <property type="nucleotide sequence ID" value="XM_031656766.1"/>
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        <property type="nucleotide sequence ID" value="XM_031661962.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPANT00000078089.1">
        <property type="protein sequence ID" value="ENSPANP00000049362.1"/>
        <property type="gene ID" value="ENSPANG00000046089.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00700000104550"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000005">
        <property type="entry name" value="Ral GTPase-activating protein, beta subunit (non-catalytic)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035224390" description="Ral GTPase-activating protein subunit beta" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="Rap-GAP" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1156"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="224"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="271"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149352" checksum="15EF29BC55440E5C" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N9L5</accession>
    <name>A0A8I5N9L5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N9L5"/>
    <dbReference type="Ensembl" id="ENSPANT00000082490.1">
        <property type="protein sequence ID" value="ENSPANP00000048864.1"/>
        <property type="gene ID" value="ENSPANG00000040191.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271826"/>
    <dbReference type="OMA" id="WESETAI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF164">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035179263" description="Ig-like domain-containing protein" evidence="13">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="205"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000048864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="363" mass="40746" checksum="A93988C0080A0AEE" modified="2022-05-25" version="1">DGVMALRTLLLLSALTKTWAGSHSLKYFHTAVSRPGCVEPRFIFVGYVDDTQFVRFDSDAANPRMQPRAPWVEQEGPEYWDQETRRARDTAQTLRVKLKTLRGYYNQSEAGSHTLQWMHGCDLGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWSAVDTAAQISEQKSNDGSEAEHQRAYLEDTCVEWLRRYLENGKETLQRSEPPKTHVTHHPVSDHEATLRCWALGFYPAEITVTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQSTIPIVGIIAGLVLLGAVVTGAVVAAVMWRRKSSGGEGRGVESDDGAQGSDESLTAYKREILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5N9T2</accession>
    <name>A0A8I5N9T2_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Muskelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MKLN1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; may form higher oligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8. Interacts with GABRA1. Interacts with the C-terminal tail of PTGER3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5N9T2"/>
    <dbReference type="Ensembl" id="ENSPANT00000070122.1">
        <property type="protein sequence ID" value="ENSPANP00000057828.1"/>
        <property type="gene ID" value="ENSPANG00000000794.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001702"/>
    <dbReference type="OMA" id="NKQDYKH"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098895">
        <property type="term" value="C:postsynaptic endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099164">
        <property type="term" value="C:postsynaptic specialization membrane of symmetric synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099003">
        <property type="term" value="P:vesicle-mediated transport in synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000018">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000035">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000066">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="CTLH" evidence="14">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="737"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="774" mass="88697" checksum="4FD1BFB6AB7A2ABE" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NDR3</accession>
    <name>A0A8I5NDR3_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parkin coregulated like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PACRGL</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_017814781.1">
        <property type="nucleotide sequence ID" value="XM_017959292.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021794749.1">
        <property type="nucleotide sequence ID" value="XM_021939057.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519950.1">
        <property type="nucleotide sequence ID" value="XM_031664090.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519951.1">
        <property type="nucleotide sequence ID" value="XM_031664091.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519953.1">
        <property type="nucleotide sequence ID" value="XM_031664093.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519954.1">
        <property type="nucleotide sequence ID" value="XM_031664094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519955.1">
        <property type="nucleotide sequence ID" value="XM_031664095.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519956.1">
        <property type="nucleotide sequence ID" value="XM_031664096.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031519957.1">
        <property type="nucleotide sequence ID" value="XM_031664097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NDR3"/>
    <dbReference type="Ensembl" id="ENSPANT00000062290.1">
        <property type="protein sequence ID" value="ENSPANP00000056644.1"/>
        <property type="gene ID" value="ENSPANG00000001123.3"/>
    </dbReference>
    <dbReference type="GeneID" id="101001407"/>
    <dbReference type="KEGG" id="panu:101001407"/>
    <dbReference type="CTD" id="133015"/>
    <dbReference type="GeneTree" id="ENSGT00940000159756"/>
    <dbReference type="OrthoDB" id="10258089at2759"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF1">
        <property type="entry name" value="PACRG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="248" mass="27245" checksum="D4B83D1594C73C40" modified="2022-05-25" version="1">MRKSEGSGGTQLKNRARGDYDQRTSSTTQIKHRNAVQGSKSSLSTSSPESARKLHPRPSDKLNPKTINPFGEQSRAPSAFAAIYSKGGIPCRLVHGSVKHRLQWECPPESLSFDPLLITLAEGLRETKHPYTFVSKEGFRELLLVRGASEKAVPLLPRLIPVLKAALVHSDDEVFERGLNALVQLSVVVGPSLNDHLKHLLTSLSKRLMDKKFKEPITSALQKLEQRGGSGSLSIIKSKIPTYCSICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NFJ5</accession>
    <name>A0A8I5NFJ5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NFJ5"/>
    <dbReference type="Ensembl" id="ENSPANT00000000109.3">
        <property type="protein sequence ID" value="ENSPANP00000051878.1"/>
        <property type="gene ID" value="ENSPANG00000017611.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164709"/>
    <dbReference type="OMA" id="HAWPKND"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000051878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="114" mass="12571" checksum="AE79F79531098498" modified="2022-05-25" version="1">NLWIQRDRGLLYTAYGSFDLVAQAGVQWHNLGLPQPPPPEFKQFSCLSLPSSWDYRCAPPCLVNFVFLVEIGFLHVGQAGLKLLTSGDPPISASQSAGIIDMSHHAWPKNDPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NGJ4</accession>
    <name>A0A8I5NGJ4_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">POU4F3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NGJ4"/>
    <dbReference type="SMR" id="A0A8I5NGJ4"/>
    <dbReference type="Ensembl" id="ENSPANT00000078524.1">
        <property type="protein sequence ID" value="ENSPANP00000056615.1"/>
        <property type="gene ID" value="ENSPANG00000048660.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160880"/>
    <dbReference type="OMA" id="GMNAKQP"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042491">
        <property type="term" value="P:inner ear auditory receptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031290">
        <property type="term" value="P:retinal ganglion cell axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021562">
        <property type="term" value="P:vestibulocochlear nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000056">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF43">
        <property type="entry name" value="POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="333"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
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                <person name="Patil S.P."/>
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                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
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                <person name="Ruiz S.-J.R."/>
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                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
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                <person name="Tisius J.T."/>
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                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
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                <person name="Weissenberger G.W."/>
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                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
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                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
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    </evidence>
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    </evidence>
    <sequence length="114" mass="13076" checksum="A055C3A92FC09EE9" modified="2022-05-25" version="1">MESGRSRWFTPVVPALWEAQHFGKPRRADHLRSGVQDQPGQHDGVSLCHPGWRAVVRSRLTAPFFPGLKQFTCPSLPTSWDYRHTPPHTVNFCIFSRIRVSPCWPGWSQTPDLK</sequence>
</entry>
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            <fullName evidence="5">Trinucleotide repeat-containing gene 18 protein</fullName>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
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                <person name="Clerc-Blankenburg K.C."/>
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                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
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                <person name="Liu Y.-S.L."/>
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                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
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                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
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                <person name="Trejos Z.T."/>
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                <person name="White C.W."/>
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            <title>Whole Genome Assembly of Papio anubis.</title>
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                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
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                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NJA2"/>
    <dbReference type="Ensembl" id="ENSPANT00000078574.1">
        <property type="protein sequence ID" value="ENSPANP00000055510.1"/>
        <property type="gene ID" value="ENSPANG00000041871.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165497"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF7">
        <property type="entry name" value="PI4-KINASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="96" mass="11030" checksum="3500B42C2A94289F" modified="2022-05-25" version="1">INLVKDYLWTQELAPNFFFFFFFFFFETESRSAAQAGVQWPDLCSLQAPPPGFTPFSCLSLPSSWDYRRPPPRPASFLVETGFHSVRQDGLDLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NLM7</accession>
    <name>A0A8I5NLM7_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neurensin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NRSN1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_021792724.2">
        <property type="nucleotide sequence ID" value="XM_021937032.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031522818.1">
        <property type="nucleotide sequence ID" value="XM_031666958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NLM7"/>
    <dbReference type="Ensembl" id="ENSPANT00000072817.1">
        <property type="protein sequence ID" value="ENSPANP00000049287.1"/>
        <property type="gene ID" value="ENSPANG00000037157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100999908"/>
    <dbReference type="KEGG" id="panu:100999908"/>
    <dbReference type="CTD" id="140767"/>
    <dbReference type="GeneTree" id="ENSGT00530000063877"/>
    <dbReference type="OMA" id="ASIWEHE"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024883">
        <property type="entry name" value="Neurensin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14796">
        <property type="entry name" value="NEURENSIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14796:SF6">
        <property type="entry name" value="NEURENSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14927">
        <property type="entry name" value="Neurensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000049287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="195" mass="21533" checksum="C26926F97BA9BB14" modified="2022-05-25" version="1">MSSCSNVCGSRQAQAAVEGGYQRYGVRSYLHQFYEDCTASIWEYEDDFQIQRSPNRWSSVFWKVGLISGTVFVILGLTVLAVGFLVPPKIEAFGEADFVVVDTHAVRFNSALDMYKLAGAVLFCIGGTSMAGCLLMSVFVKSYSKEEKFLQQKFKERIADIKVHTQPVTKAPGPGETKIPVTLSRVQNVQPLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNK9</accession>
    <name>A0A8I5NNK9_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNK9"/>
    <dbReference type="Ensembl" id="ENSPANT00000078132.1">
        <property type="protein sequence ID" value="ENSPANP00000055263.1"/>
        <property type="gene ID" value="ENSPANG00000021551.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162088"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF348">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="117"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="477" mass="52605" checksum="8374D00E76B20329" modified="2022-05-25" version="1">MFHRGLESPEPELLAKLQPSSASTMATQTCSPTFSTGSVKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSARSGLSGLGSCLPGSYLSSGCHSSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELEATLLERSKCHESTVCPDYQSYFRTIEELQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLRQLVEADQCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKLRIELDIEPTIDLNRVLGEMRAQYEAMVETNRQDVEQWFQAQSEGISLQAMSCSEELQCCQSEILELRRSVNALEVELQAQHTLRDCLQNSLCEAEDRYGTELAQMQSLINNVEEQLSEIRADLERQNQEYQVLLDVKARLENEIATYRNLLESEDCNLPSNPCATTNACSKSIGPCVSNPCTPCVPPAPCTPCAPRPRCGPCNSFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NNV5</accession>
    <name>A0A8I5NNV5_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Golgi membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GOLM1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NNV5"/>
    <dbReference type="Ensembl" id="ENSPANT00000063087.1">
        <property type="protein sequence ID" value="ENSPANP00000055431.1"/>
        <property type="gene ID" value="ENSPANG00000024888.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063675"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026139">
        <property type="entry name" value="GOLM1/CASC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896:SF8">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 2/GP73-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02084">
        <property type="entry name" value="GOLM1CASC4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="512" mass="57289" checksum="ECD2BC12E39E52F8" modified="2022-05-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NPD1</accession>
    <name>A0A8I5NPD1_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NPD1"/>
    <dbReference type="Ensembl" id="ENSPANT00000070494.1">
        <property type="protein sequence ID" value="ENSPANP00000055365.1"/>
        <property type="gene ID" value="ENSPANG00000042847.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271815"/>
    <dbReference type="OMA" id="ITITAHC"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138:SF162">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12138">
        <property type="entry name" value="PRIMATE-EXPANDED PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000055365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="104" mass="10849" checksum="A8C086573586FE1C" modified="2022-05-25" version="1">MSPRLECNGALSAHCNLHLPGSSDSPASASQVAGVTGACHHTQLIFVFLVEKGFHHVGQAGLQLLTLGDLPALASQSAGITGVSHHAWPSTYIFLLNPHNGSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NQ06</accession>
    <name>A0A8I5NQ06_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NQ06"/>
    <dbReference type="Ensembl" id="ENSPANT00000078699.1">
        <property type="protein sequence ID" value="ENSPANP00000056079.1"/>
        <property type="gene ID" value="ENSPANG00000049849.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000056079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="120" mass="13481" checksum="60A74F71444E4486" modified="2022-05-25" version="1">NVFLSYLSFCLFVFVFVFLRWSLTLLPRVRGHYISSLQPPPPGFKRFSCLSLLSSWDYRYPPPRLANFCIFKTGFCHVGQAGLELLASSDPPALASQSAGITGVHHRAWPTAMFSYFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NSM5</accession>
    <name>A0A8I5NSM5_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8I5NSM5"/>
    <dbReference type="Ensembl" id="ENSPANT00000083634.1">
        <property type="protein sequence ID" value="ENSPANP00000057531.1"/>
        <property type="gene ID" value="ENSPANG00000049537.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164691"/>
    <dbReference type="OMA" id="THTKLEI"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002737">
        <property type="entry name" value="AGAP008430-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001004">
        <property type="entry name" value="Zinc finger protein 426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001310">
        <property type="entry name" value="zinc finger protein 664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002280">
        <property type="entry name" value="Zinc finger protein 669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002010">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000057531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="272" mass="31042" checksum="C50CDB85FFAD92F3" modified="2022-05-25" version="1">MVQRLCESKEGSQCGEVVSQIPNLDLNENISAGLKQCECSICGKVFVRHSLLNRHILAHSGYKPYGEKQYKCEQCGKFFVSVPGVRRHRIMHSGNPAYKCTICGKAFYFLNSVERHQRTHTGEKPYKCKQCGKAFTVSGSCLIHERTHTGEKPYECKECGKTFRFSCSFKTHERTHTGERPYKCTKCDKAFSCSTSLRYHGSIHTGERPYECKQCGKAFSRLSSLCNHRSTHTGEKPYECKQCDQAFSRLSSLHLHERIHTGEKPYECKRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU87</accession>
    <name>A0A8I5NU87_PAPAN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU87"/>
    <dbReference type="Ensembl" id="ENSPANT00000067859.1">
        <property type="protein sequence ID" value="ENSPANP00000061144.1"/>
        <property type="gene ID" value="ENSPANG00000050037.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161627"/>
    <dbReference type="OMA" id="WPHILIY"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254">
        <property type="entry name" value="PROTEIN GVQW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46254:SF3">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02045">
        <property type="entry name" value="F138DOMAIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPANP00000061144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028761"/>
        </source>
    </evidence>
    <sequence length="99" mass="10966" checksum="37E3AEA1F970ACB2" modified="2022-05-25" version="1">MESRSVTQAGVQWWDLSSLQPPPPGFKQFSCFSLLSSCDYRHVPPCPANFIFLVETGYHHVGQAGFELLTSGDPPALTSQSAGITGVRHHTWPHILIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8I5NU98</accession>
    <name>A0A8I5NU98_PAPAN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Casein kinase II subunit alpha</fullName>
            <shortName evidence="8">CK II alpha</shortName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CSNK2A2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papio anubis</name>
        <name type="common">Olive baboon</name>
        <dbReference type="NCBI Taxonomy" id="9555"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Haplorrhini</taxon>
            <taxon>Catarrhini</taxon>
            <taxon>Cercopithecidae</taxon>
            <taxon>Cercopithecinae</taxon>
            <taxon>Papio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Whole Genome Assembly of Papio anubis.</title>
            <authorList>
                <person name="Liu Y.L."/>
                <person name="Abraham K.A."/>
                <person name="Akbar H.A."/>
                <person name="Ali S.A."/>
                <person name="Anosike U.A."/>
                <person name="Aqrawi P.A."/>
                <person name="Arias F.A."/>
                <person name="Attaway T.A."/>
                <person name="Awwad R.A."/>
                <person name="Babu C.B."/>
                <person name="Bandaranaike D.B."/>
                <person name="Battles P.B."/>
                <person name="Bell A.B."/>
                <person name="Beltran B.B."/>
                <person name="Berhane-Mersha D.B."/>
                <person name="Bess C.B."/>
                <person name="Bickham C.B."/>
                <person name="Bolden T.B."/>
                <person name="Carter K.C."/>
                <person name="Chau D.C."/>
                <person name="Chavez A.C."/>
                <person name="Clerc-Blankenburg K.C."/>
                <person name="Coyle M.C."/>
                <person name="Dao M.D."/>
                <person name="Davila M.L.D."/>
                <person name="Davy-Carroll L.D."/>
                <person name="Denson S.D."/>
                <person name="Dinh H.D."/>
                <person name="Fernandez S.F."/>
                <person name="Fernando P.F."/>
                <person name="Forbes L.F."/>
                <person name="Francis C.F."/>
                <person name="Francisco L.F."/>
                <person name="Fu Q.F."/>
                <person name="Garcia-Iii R.G."/>
                <person name="Garrett T.G."/>
                <person name="Gross S.G."/>
                <person name="Gubbala S.G."/>
                <person name="Hirani K.H."/>
                <person name="Hogues M.H."/>
                <person name="Hollins B.H."/>
                <person name="Jackson L.J."/>
                <person name="Javaid M.J."/>
                <person name="Jhangiani S.J."/>
                <person name="Johnson A.J."/>
                <person name="Johnson B.J."/>
                <person name="Jones J.J."/>
                <person name="Joshi V.J."/>
                <person name="Kalu J.K."/>
                <person name="Khan N.K."/>
                <person name="Korchina V.K."/>
                <person name="Kovar C.K."/>
                <person name="Lago L.L."/>
                <person name="Lara F.L."/>
                <person name="Le T.-K.L."/>
                <person name="Lee S.L."/>
                <person name="Legall-Iii F.L."/>
                <person name="Lemon S.L."/>
                <person name="Liu J.L."/>
                <person name="Liu Y.-S.L."/>
                <person name="Liyanage D.L."/>
                <person name="Lopez J.L."/>
                <person name="Lorensuhewa L.L."/>
                <person name="Mata R.M."/>
                <person name="Mathew T.M."/>
                <person name="Mercado C.M."/>
                <person name="Mercado I.M."/>
                <person name="Morales K.M."/>
                <person name="Morgan M.M."/>
                <person name="Munidasa M.M."/>
                <person name="Ngo D.N."/>
                <person name="Nguyen L.N."/>
                <person name="Nguyen T.N."/>
                <person name="Nguyen N.N."/>
                <person name="Obregon M.O."/>
                <person name="Okwuonu G.O."/>
                <person name="Ongeri F.O."/>
                <person name="Onwere C.O."/>
                <person name="Osifeso I.O."/>
                <person name="Parra A.P."/>
                <person name="Patil S.P."/>
                <person name="Perez A.P."/>
                <person name="Perez Y.P."/>
                <person name="Pham C.P."/>
                <person name="Pu L.-L.P."/>
                <person name="Puazo M.P."/>
                <person name="Quiroz J.Q."/>
                <person name="Rouhana J.R."/>
                <person name="Ruiz M.R."/>
                <person name="Ruiz S.-J.R."/>
                <person name="Saada N.S."/>
                <person name="Santibanez J.S."/>
                <person name="Scheel M.S."/>
                <person name="Schneider B.S."/>
                <person name="Simmons D.S."/>
                <person name="Sisson I.S."/>
                <person name="Tang L.-Y.T."/>
                <person name="Thornton R.T."/>
                <person name="Tisius J.T."/>
                <person name="Toledanes G.T."/>
                <person name="Trejos Z.T."/>
                <person name="Usmani K.U."/>
                <person name="Varghese R.V."/>
                <person name="Vattathil S.V."/>
                <person name="Vee V.V."/>
                <person name="Walker D.W."/>
                <person name="Weissenberger G.W."/>
                <person name="White C.W."/>
                <person name="Williams A.W."/>
                <person name="Woodworth J.W."/>
                <person name="Wright R.W."/>
                <person name="Zhu Y.Z."/>
                <person name="Han Y.H."/>
                <person name="Newsham I.N."/>
                <person name="Nazareth L.N."/>
                <person name="Worley K.W."/>
                <person name="Muzny D.M."/>
                <person name="Rogers J.R."/>
                <person name="Gibbs R.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8I5NU98"/>
    <dbReference type="Ensembl" id="ENSPANT00000069198.1">
        <property type="protein sequence ID" value="ENSPANP00000053646.1"/>
        <property type="gene ID" value="ENSPANG00000041238.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004215"/>
    <dbReference type="OMA" id="ACEKRPQ"/>
    <dbReference type="Proteomes" id="UP000028761">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="pr